Tokushima University / Educator and Researcher Directory --- Hanawa, Shigeki

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Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Orthodontics ⟩
Tokushima University ⟩ Faculty of Dentistry ⟩ Course in Dentistry ⟩ Clinical Dentistry for Promotion and Development ⟩ Orthodontics and Dentofacial Orthodontics ⟩

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Research

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Shigeki Hanawa, Kazumitsu Sekine, Yeeun Kim, Shinya Horiuchi, Keiko Miyoshi, Eiji Tanaka and Kenichi Hamada : Effects of adding poloxamer, collagen, and citric acid on mechanical strength, injectability, shape stability, and biocompatibility of mechanochemically modified beta-tricalcium phosphate cement using ball milling., Dental Materials Journal, 44, 3, 355-364, 2025. (Summary) This study focuses on enhancing the mechanical properties and biocompatibility of calcium phosphate cement (CPC), a widely used bone replacement material. CPCs are limited by low mechanical strength and susceptibility to washout in body fluids. Four approaches were employed to improve CPC performance: 1. mechanochemical modification of CPC powder by ball milling to produce modified β-tricalcium phosphate (mβ-TCP) for better strength and injectability; 2. incorporation of poloxamer, a reverse thermosensitive gel, to enhance shape stability at body temperature; 3. addition of type I collagen to promote the cell viability and alkaline phosphatase (ALP) activity of osteoblast-like cells; 4. citric acid inclusion to restore compressive strength and injectability compromised by collagen. The resulting high-performance CPC demonstrated a compressive strength of 50.1 MPa, with significant improvements in injectability, shape stability, cell viability, and ALP activity of osteoblast-like cells. (Keyword) Calcium Phosphates / Citric Acid / Poloxamer / Bone Cements / Cell Survival / Materials Testing / Osteoblasts / Compressive Strength / Biocompatible Materials / collagen / Alkaline Phosphatase / Animals / Humans (Tokushima University Institutional Repository) ● Metadata: 2013273 (Link to Publication Site) ● Publication site (DOI): 10.4012/dmj.2024-369 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 40301065 ● Search Scopus @ Elsevier (PMID): 40301065 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2024-369 (Tokushima University Institutional Repository: 2013273, DOI: 10.4012/dmj.2024-369, PubMed: 40301065)

Proceeding of Domestic Conference:

1.	Shigeki Hanawa, Kazumitsu Sekine, 和田涼平, Yuta Matsuki, Shinya Horiuchi, Eiji Tanaka and Kenichi Hamada : ボールミリング法で改質したリン酸カルシウムセメントへのポロキサマー・コラーゲン・クエン酸ゲル添加効果, 日本矯正歯科学会大会プログラム・抄録集, 200, Oct. 2024.
2.	和田涼平, Emi Takegawa, Shigeki Hanawa, Yuta Matsuki, Shinya Horiuchi, Eiji Tanaka and Kenichi Hamada : レジン添加型グラスアイオノマーセメントの接着強度に印加電圧の変動が与える影響, 日本矯正歯科学会大会プログラム・抄録集, 201, Oct. 2024.
3.	Takeshi Nishino, Masahiro Hiasa, Shigeki Hanawa, NAKAGAWA Motosumi, Yuta Matsuki, Sou Shimizu, Shinya Horiuchi and Eiji Tanaka : 上顎過成長と下顎劣成長を伴う骨格性上顎前突の兄妹症例, The Journal of Chu-Shikoku Orthodontic Society, 36, 1, 93-94, Aug. 2024. (Keyword) 下顎骨顎顎前突症(診断,治療,予後) 顔面上顎骨きょうだい顎顔面領域ヒト小児(6∼12) 男女歯学
4.	Shigeki Hanawa, Kazumitsu Sekine, Kim Yeeun, Eiji Tanaka and Kenichi Hamada : ボールミリング法で改質したリン酸カルシウムセメントへのポロキサマー・コラーゲン・クエン酸ゲルの添加効果, 第82回日本歯科理工学会学術講演会, Apr. 2024.