Tokushima University / Educator and Researcher Directory --- Matsuki, Suha

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Research

Field of Study

○	Molecular Cell Biology

Subject of Study

○	Myeloma cell growth suppression by osteoblast-derived extracellular vesicles: the creation of a non-permissive niche for myeloma cells by bone-forming osteoblasts

Book / Paper

Academic Paper (Judged Full Paper):

1.	Keiichiro Watanabe, Kaoru Yoshinaga, Suha Matsuki, Mima Shunsuke, Yamasaki Hiroyuki, Kazuhide Mineda, Masashi Suzue, Ryuji Nakagawa, Suga Kenichi, Takashi Kaji, Ichiro Hashimoto and Eiji Tanaka : Presurgical orthodontic treatment with ultraearly application of premaxilla-guiding nasoalveolar molding in feeding neonates. A case series., JADA Foundational Science, 4, C, 100055, 2025. (Keyword) Cleft lip and palate / presurgical orthodontic treatment / nasoalveolar molding
2.	Suha Matsuki : Myeloma cell growth suppression by osteoblast-derived extracellular vesicles: the creation of a non-permissive niche for myeloma cells by bone-forming osteoblasts, Haematologica, 110, 6, 1395-1401, 2025.
3.	Shinohara Takehiro, Keiichiro Watanabe, Daishi Arai, Akihiko Iwasa, SooHa Kim, WADA Ryohei, Shinya Horiuchi and Eiji Tanaka : Scissor bite correction with miniscrew-anchored uprighting: A case report, AJO-DO Clinical Companion, 5, 1, 82-92, 2025. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.xaor.2024.10.001 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.xaor.2024.10.001 (DOI: 10.1016/j.xaor.2024.10.001)
4.	SooHa Kim, Jumpei Teramachi, Masahiro Hiasa, Ryota Amachi, Ariunzaya Bat-Erdene, Asuka Oda, Hirofumi Tenshin, Mariko Tanaka, Motosumi Nakagawa, Aiko Seki, Yoshihiko Sawa, Ken-ichi Matsuoka, Eiji Tanaka, Takeshi Harada, Tatsuya Tominaga and Masahiro Abe : Myeloma cell growth suppression by osteoblast-derived extracellular vesicles: the creation of a non-permissive niche for myeloma cells by bone-forming osteoblasts., Haematologica, 110, 6, 1395-1401, 2025. (Summary) Not available. (Tokushima University Institutional Repository) ● Metadata: 2013272 (Link to Publication Site) ● Publication site (DOI): 10.3324/haematol.2024.286554 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39844765 ● Summary page in Scopus @ Elsevier: 2-s2.0-105007334328 (Tokushima University Institutional Repository: 2013272, DOI: 10.3324/haematol.2024.286554, PubMed: 39844765, Elsevier: Scopus)
5.	Yoshiki Higa, Masahiro Hiasa, Hirofumi Tenshin, Emiko Nakaue, Mariko Tanaka, SooHa Kim, Motosumi Nakagawa, Sou Shimizu, Kotaro Tanimoto, Jumpei Teramachi, Takeshi Harada, Asuka Oda, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Hiroki Yamagami, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe : The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and Activates Nrf2., Antioxidants, 12, 1, 2023. (Summary) Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine catabolism that acts as a novel regulator of adipogenesis. In pathological states, xanthine oxidoreductase activity increases to produce excess reactive oxygen species (ROS). The nuclear factor erythroid 2-related factor 2 (Nrf2) is a critical inducer of antioxidants, which is bound and repressed by a kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm. The Keap1-Nrf2 axis appears to be a major mechanism for robust inducible antioxidant defenses. Here, we demonstrate that febuxostat, a xanthine oxidase inhibitor, alleviates the increase in adipose tissue mass in obese mouse models with a high-fat diet or ovariectomy. Febuxostat disrupts in vitro adipocytic differentiation in adipogenic media. Adipocytes appeared at day 7 in absence or presence of febuxostat were 160.8 ± 21.2 vs. 52.5 ± 12.7 (p < 0.01) in 3T3L1 cells, and 126.0 ± 18.7 vs. 55.3 ± 13.4 (p < 0.01) in 10T1/2 cells, respectively. Adipocyte differentiation was further enhanced by the addition of hydrogen peroxide, which was also suppressed by febuxostat. Interestingly, febuxostat, but not allopurinol (another xanthine oxidase inhibitor), rapidly induced the nuclear translocation of Nrf2 and facilitated the degradation of Keap1, similar to the electrophilic Nrf2 activator omaveloxolone. These results suggest that febuxostat alleviates adipogenesis under oxidative conditions, at least in part by suppressing ROS production and Nrf2 activation. Regulation of adipocytic differentiation by febuxostat is expected to inhibit obesity due to menopause or overeating. (Tokushima University Institutional Repository) ● Metadata: 2011068 (Link to Publication Site) ● Publication site (DOI): 10.3390/antiox12010133 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36670994 ● Summary page in Scopus @ Elsevier: 2-s2.0-85146779366 (Tokushima University Institutional Repository: 2011068, DOI: 10.3390/antiox12010133, PubMed: 36670994, Elsevier: Scopus)

Proceeding of International Conference:

1.	SooHa Kim, Jumpei Teramachi, Masahiro Hiasa, A Oda, Hirofumi Tenshin, Sou Shimizu, Emiko Nakaue, Yoshiki Higa, TANAKA Mariko, NAKAGAWA Motosumi, YAMASHITA Akimi, Takeshi Nishino, Itsuro Endo, Eiji Tanaka, Takeshi Harada, T Tominaga and Masahiro Abe : Critical roles of miR-125b-contained EV in formation of an osteoblast-induced non-permissive niche for myeloma cells, ASBMR 2024, Toronto, Sep. 2024.

Proceeding of Domestic Conference:

1.	SooHa Kim, Jumpei Teramachi, Masahiro Hiasa, Sou Shimizu, Emiko Nakaue, Yoshiki Higa, 田中茉里子, 中川宗純, 山下明観, 西野豪, Eiji Tanaka, Takeshi Harada, Tatsuya Tominaga and Masahiro Abe : 骨芽細胞由来細胞外小胞による骨髄腫排他的ニッチ形成の分子機序の解明, 第86回日本血液学会学術集会抄録集, Oct. 2024.
2.	SooHa Kim, Jumpei Teramachi, Masahiro Hiasa, Hirofumi Tenshin, Sou Shimizu, Emiko Nakaue, NAKAGAWA Motosumi, Eiji Tanaka and Masahiro Abe : 骨芽細胞由来細胞外小胞による骨髄腫排他的ニッチ形成の分子機序の解明, 日本矯正歯科学会大会プログラム・抄録集, 246, Oct. 2024.
3.	Keiichiro Watanabe, SooHa Kim, YAMASHITA Akimi, 坂巻拓馬, Kaoru Yoshinaga and Eiji Tanaka : 機能性下顎近心咬合を伴う成人骨格性下顎前突症例, 日本矯正歯科学会大会プログラム・抄録集, 266, Oct. 2024.
4.	YAMASHITA Akimi, Keiichiro Watanabe, WADA Ryohei, SooHa Kim, TANAKA Mariko, Emiko Nakaue, Kaoru Yoshinaga and Eiji Tanaka : 徳島大学病院矯正歯科における顎偏位症患者の後戻りに関する臨床統計調査, The Journal of Chu-Shikoku Orthodontic Society, Aug. 2024.
5.	SooHa Kim, Jumpei Teramachi, Masahiro Hiasa, 小田明日香, Sou Shimizu, Emiko Nakaue, Yoshiki Higa, 田中茉里子, 中川宗純, 山下明観, 西野豪, Eiji Tanaka, Takeshi Harada, Tatsuya Tominaga and Masahiro Abe : 骨形成誘導による骨髄腫排他的ニッチ形成の分子機序, 第42回日本骨代謝学会学術集会抄録集, Jul. 2024.
6.	SooHa Kim, Jumpei Teramachi, Masahiro Hiasa, Sou Shimizu, Emiko Nakaue, Yoshiki Higa, 田中茉里子, 中川宗純, 山下明観, 西野豪, Eiji Tanaka, 原田武志 and Masahiro Abe : 骨形成誘導による骨髄腫排他的ニッチ形成の分子機序, 第49回日本骨髄腫学会学術集会, May 2024.
7.	Emiko Nakaue, Jumpei Teramachi, Masahiro Hiasa, Sou Shimizu, Yoshiki Higa, TANAKA Mariko, SooHa Kim, NAKAGAWA Motosumi, Eiji Tanaka and Masahiro Abe : プロテアソーム阻害薬による骨髄腫骨病変部における骨形成のメカニズム, 第82回日本矯正歯科学会学術大会抄録集, 192, Nov. 2023.
8.	Yoshiki Higa, Masahiro Hiasa, NAKAGAWA Motosumi, SooHa Kim, TANAKA Mariko, Emiko Nakaue, Sou Shimizu, Hirofumi Tenshin, Eiji Tanaka and Masahiro Abe : KEAP1-NRF2軸を介した脂肪細胞分化と骨芽細胞分化の制御機構, 第82回日本矯正歯科学会学術大会抄録集, 194, Nov. 2023.
9.	NAKAGAWA Motosumi, Masahiro Hiasa, HANAWA Shigeki, SooHa Kim, Yoshiki Higa, Yuta Matsuki, Shinya Horiuchi and Eiji Tanaka : 上顎骨前方部延長術を行った口唇口蓋裂患者2症例の術後評価, The Journal of Chu-Shikoku Orthodontic Society, 35, 1, 112-113, Aug. 2023. (Keyword) 口蓋裂(外科的療法,診断) 口唇裂(外科的療法,診断) 骨延長法上顎骨治療成績ヒト歯学
10.	SooHa Kim, Jumpei Teramachi, Masahiro Hiasa, Hirofumi Tenshin, Emiko Nakaue, TANAKA Mariko, NAKAGAWA Motosumi, Itsuro Endo, Takeshi Harada, Eiji Tanaka and Masahiro Abe : Molecular mechanisms for generation of non-permissive niche for myeloma cells by activated osteoblasts., The Annual Meeting of the Japanese Society for Bone and Mineral Research Program & Abstracts, 173, Jul. 2023.
11.	Keiichiro Watanabe, Kaoru Yoshinaga, SooHa Kim, HANAWA Shigeki, TANAKA Mariko, Hiroyuki Yamasaki, Kazuhide Mineda, Shinya Horiuchi, Ichiro Hashimoto and Eiji Tanaka : 中間顎誘導型NAMの早期装着により,短期間で中間顎の整位を行った両側性唇顎口蓋裂の3, Journal fo Japanese Cleft Palate Association, 48, 2, 133, May 2023. (Keyword) 唇顎口蓋裂(治療) / 術前顎矯正治療 / statistics / ヒト; 新生児; 男; 女; 歯学
12.	WADA Ryohei, Keiichiro Watanabe, Kaoru Yoshinaga, SooHa Kim, HANAWA Shigeki, TANAKA Mariko, Yuki Sakamoto, Aki Shimada, Eiji Kondou, Takamasa Kitamura, Hiroyuki Yamasaki, Kazuhide Mineda, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における過去10年間の口唇裂・口蓋裂患者に関する臨床統計調査, Journal fo Japanese Cleft Palate Association, 48, 2, 200, May 2023. (Keyword) 口蓋裂 / statistics / 大学病院 / ヒト; 男; 女; 歯学
13.	Kazuhide Mineda, SooHa Kim, Keiichiro Watanabe, 山崎裕行, Yutaro Yamashita, Yoshiro Abe, Eiji Tanaka and Ichiro Hashimoto : 徳島大学病院口唇口蓋裂センター設立前後での患者動向の検討, 第40回日本頭蓋顎顔面外科学会学術集会, Nov. 2022.
14.	Yoshiki Higa, Masahiro Hiasa, SooHa Kim, TANAKA Mariko, Emiko Nakaue, Sou Shimizu, Kotaro Tanimoto, Hirofumi Tenshin, Eiji Tanaka and Masahiro Abe : キサンチンオキシダーゼ阻害薬febuxostatはKEAP1-NRF2軸を介し脂肪細胞分化と骨芽細胞分化を制御する, 第81回日本矯正歯科学会学術大会, Oct. 2022.
15.	TANAKA Mariko, Masahiro Hiasa, Kotaro Tanimoto, Hirofumi Tenshin, Sou Shimizu, Yoshiki Higa, Emiko Nakaue, SooHa Kim, Jumpei Teramachi, Takeshi Harada, Shingen Nakamura, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe : 不動は骨髄腫骨病変部DPP-4発現増加と骨髄腫の腫瘍進展・髄外播種を加速させる, 第40回日本骨代謝学会学術集会, Jul. 2022.
16.	Takuma Sakamaki, Keiichiro Watanabe, Akihiko Iwasa, SooHa Kim and Eiji Tanaka : 歯科矯正用アンカースクリューの初期安定性に対する皮質骨厚の影響, The Journal of Chu-Shikoku Orthodontic Society, Jul. 2022.
17.	SooHa Kim, Keiichiro Watanabe, Kaoru Yoshinaga, Hirofumi Tenshin, Emiko Nakaue, Yoshiki Higa, 坂本幸, 近藤英司, Aki Shimada, Kazuhide Mineda, Soushi Ishida, Aya Miyazaki, Takamasa Kitamura, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における口唇口蓋裂センター設立前後での患者動向の変化金秀河(徳島大学大学院口腔科学教育部口腔顎顔面矯正学分野), 渡邉佳一郎, 吉永薫, 天眞寛文, 中上絵美子, 比嘉佳基, 坂本幸, 近藤英司, 島田亜紀, 峯田一秀, 石田創士, 宮嵜彩, 北村尚正, 日浅雅博, 堀内信也, 岩崎智憲, 橋本一郎, 田中栄二日本口蓋裂学会雑誌(0386-5185)47巻2号 Page135(2022.04), Journal fo Japanese Cleft Palate Association, 47, 2, 135, May 2022.