Tokushima University / Educator and Researcher Directory --- Hanada, Kenta

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Kenta Hanada, Shotaro Haji, Koji Fukushima, Hiroki Yamazaki, Yusuke Osaki, Naoko Takamatsu, Koji Fujita and Yuishin Izumi : Increase in the amyotrophic lateral sclerosis age of onset: Analysis of cases originating in 2011-2020, The Journal of Medical Investigation : JMI, 72, 3,4, 286-289, 2025. (Summary) The onset age of amyotrophic lateral sclerosis (ALS) has been increasing, but recent trends remain unclear. This study examined changes in ALS onset age over the past decade. We analyzed 233 ALS patients diagnosed from 2011 to 2020 at Tokushima University Hospital. The Jonckheere-Terpstra test assessed the trend in onset age. We compared onset age between 2011-2015 (Group A) and 2016-2020 (Group B) using the Mann-Whitney U test. We also analyzed the annual proportion of patients with onset age ≥80 using Spearman's rank correlation. In Tokushima Prefecture, we evaluated annual increase rates of individuals aged ≥80 and ALS patients with onset age ≥80, using 2011 as baseline. Regression slopes were compared using a t test. Onset age showed a significant positive trend (p=0.04), and Group B had older onset age than Group A (p=0.048). The proportion of patients with onset age ≥80 increased significantly (ϱ=0.69, p=0.03). No significant difference was found between regression slopes for the general elderly population and ALS patients with onset age ≥80 (p=0.49). These findings suggest that the onset age of ALS at Tokushima University Hospital has increased over the past decade. J. Med. Invest. 72 : 286-289, August, 2025. (Keyword) Humans / Amyotrophic Lateral Sclerosis / Age of Onset / Male / Female / Aged, 80 and over / Aged / Japan / Middle Aged / Adult (Tokushima University Institutional Repository) ● Metadata: 2013640 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.72.286 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41183928 ● Search Scopus @ Elsevier (PMID): 41183928 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.72.286 (Tokushima University Institutional Repository: 2013640, DOI: 10.2152/jmi.72.286, PubMed: 41183928)
2.	Shotaro Haji, Wataru Sako, Kenta Hanada, Tomoyasu Matsubara, Yusuke Osaki, Yuki Matsumoto, Masafumi Harada and Yuishin Izumi : Magnetic Susceptibility and Area in the Subthalamic Nucleus Measured by QSM for Diagnosis of Progressive Supranuclear Palsy, Movement Disorders Clinical Practice, 12, 10, 1602-1608, 2025. (Keyword) magnetic resonance imaging / Parkinson's disease / progressive supra nuclear palsy / quantitative susceptibility mapping (Link to Publication Site) ● Publication site (DOI): 10.1002/mdc3.70153 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-105006977419 (DOI: 10.1002/mdc3.70153, Elsevier: Scopus)
3.	Kenta Hanada, Yusuke Osaki, Ryosuke Miyamoto, Kohei Muto, Shotaro Haji, Keyoumu Nazere, Yuki Kuwano, Hiroyuki Morino, Yoshiteru Azuma, Satoko Miyatake, Naomichi Matsumoto and Yuishin Izumi : Intermediate phenotype between CMT2Z and DIGFAN associated with a novel MORC2 variant: a case report., Human Genome Variation, 11, 1, 29, 2024. (Summary) Charcot-Marie-Tooth disease type 2Z is caused by MORC2 mutations and presents with axonal neuropathy. MORC2 mutations can also manifest as developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy (DIGFAN). We report a patient exhibiting an intermediate phenotype between these diseases associated with a novel MORC2 variant. A literature review revealed that the genotype‒phenotype correlation in MORC2-related disorders is complex and that the same mutation can cause a variety of phenotypes. (Tokushima University Institutional Repository) ● Metadata: 2012806 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41439-024-00287-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39143067 ● Summary page in Scopus @ Elsevier: 2-s2.0-85201316762 (Tokushima University Institutional Repository: 2012806, DOI: 10.1038/s41439-024-00287-8, PubMed: 39143067, Elsevier: Scopus)
4.	Kenta Hanada, Yusuke Osaki, Koji Fujita, Tatsuya Fukumoto, Koji Fukushima, Hideki Kito and Yuishin Izumi : Segmental Zoster Paresis Accompanied by Horner's Syndrome., Internal Medicine, 62, 18, 2743-2746, 2023. (Summary) We herein report a 90-year-old immunocompromised woman who developed right upper limb weakness and right ptosis with a miotic pupil 1 week after oral therapy for zoster on the right T2 dermatome. The right pupil was dilated with instillation of 1% apraclonidine, indicating Horner's syndrome. The patient was treated with intravenous acyclovir and methylprednisolone. Focal weakness related to zoster, generally known as segmental zoster paresis, improved over five months, but Horner's syndrome remained. We suggest that aggressive intravenous treatment should be considered for rare cases of zoster that occur with a combination of these two neurological conditions. (Keyword) Aged, 80 and over / Female / Humans / Acyclovir / Blepharoptosis / Herpes Zoster / Horner Syndrome / Paresis (Tokushima University Institutional Repository) ● Metadata: 2011950 (Link to Publication Site) ● Publication site (DOI): 10.2169/internalmedicine.0578-22 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37722924 ● Summary page in Scopus @ Elsevier: 2-s2.0-85171696243 (Tokushima University Institutional Repository: 2011950, DOI: 10.2169/internalmedicine.0578-22, PubMed: 37722924, Elsevier: Scopus)
5.	Shoko Miyamoto, 山村里恵, 敷地孝法, 三好彩佳, Kenta Hanada and 稲葉香織 : 広範な血栓性静脈炎を呈し腸管ベーチェット病が疑われた1例, Hifuka No Rinsho, 62, 8, 1150-1153, 2020. (Keyword) 腸管ベーチェット病 / 血栓性静脈炎 (Link to Publication Site) ● Publication site (DOI): 10.18888/hi.0000002080 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390003825211360896 ● Search Scopus @ Elsevier (DOI): 10.18888/hi.0000002080 (DOI: 10.18888/hi.0000002080, CiNii: 1390003825211360896)

Proceeding of Domestic Conference:

1.	Yuri Hayashi, Ryohei Nakao, Kenta Hanada, Tatsuya Fukumoto, Hiroki Yamazaki, Yusuke Osaki, Ryosuke Miyamoto, Nobuaki Yamamoto, Koji Fujita, Naoko Matsui and Yuishin Izumi : Good症候群に筋炎を合併し呼吸不全に至った胸腺腫関連重症筋無力症(TAMG)の1例, 第119回日本神経学会中国・四国地方会, Jun. 2026.
2.	Kenta Hanada, Nobuaki Yamamoto, Koji Fujita, Naoko Matsui and Yuishin Izumi : 可逆性脳梁膨大部病変を有する軽症脳炎・脳症(MERS)を呈したマイコプラズマ感染症の1例, 日本内科学会第134回四国地方会, Jun. 2026.
3.	Kazuki Sogawa, Ryohei Nakao, 谷美紀, Kenta Hanada, Tatsuya Fukumoto, Yuki Yamamoto, Hiroki Yamazaki, Yusuke Osaki, 髙松直子, Nobuaki Yamamoto, Naoko Matsui and Yuishin Izumi : フィッシャー症候群の臨床的・電気生理学的特徴, 第67回日本神経学会学術大会, May 2026.
4.	Ryohei Nakao, Kazuki Sogawa, KASAYA Kokone, 谷美紀, 髙松直子, Kenta Hanada, Tatsuya Fukumoto, Yuki Yamamoto, Hiroki Yamazaki, Yusuke Osaki, Nobuaki Yamamoto, Naoko Matsui and Yuishin Izumi : COVID-19流行に伴うギラン/バレー症候群の疫学変化, 第67回日本神経学会学術大会, May 2026.
5.	Hiroki Yamazaki, Takeshi Yoshida, 髙松直子, Kenta Hanada, Tatsuya Fukumoto, Yusuke Osaki, Naoko Matsui and Yuishin Izumi : 封入体筋炎における新たな筋超音波スケールと下肢機能との関連, 第67回日本神経学会学術大会, May 2026.
6.	Tatsuya Fukumoto, Yusuke Osaki, Kenta Hanada, Koji Fujita, Ryuji Kaji and Yuishin Izumi : 筋萎縮性側索硬化症の診断における顎二腹筋(前腹)の針筋電図検査の有用性, 第67回日本神経学会学術大会, May 2026.
7.	NAOE Haruka, Tomoyasu Matsubara, Kenta Hanada, Masaki Kamada, Kazuki Sogawa, 谷美紀, Ryosuke Miyamoto, Koji Fujita, Hiroyuki Morino and Yuishin Izumi : 徳島県のアルツハイマー型認知症患者におけるAPOE遺伝型と発症年齢の解析, 第37回日本老年医学会四国地方会, Feb. 2026.
8.	Kenta Hanada, Tomoyasu Matsubara, Kazuki Sogawa, 谷美紀, Koji Fujita and Yuishin Izumi : 80歳以上の高齢者における抗アミロイドβ抗体薬の有害事象プロファイルについての検討, 第37回日本老年医学会四国地方会, Feb. 2026.
9.	Kenta Hanada, Yuki Yamamoto, Naoki Kihara, TACHIBANA Konoka, Ryosuke Miyamoto, Koji Fujita, Naoko Matsui and Yuishin Izumi : 急速進行性認知症を呈し免疫療法が奏効した抗NAE抗体陽性脳症の1例, 一般社団法人日本内科学会第133回四国地方会, Nov. 2025.
10.	Kenta Hanada, Tomoyasu Matsubara, Naoki Kihara, Tatsuya Fukumoto, Ryosuke Miyamoto, Koji Fujita, Masaki Kamada, Hiroyuki Morino, 原範和, 池内健 and Yuishin Izumi : 認知機能障害を主徴としたSCA48の1例, 第44回日本認知症学会学術集会, Nov. 2025.
11.	Kenta Hanada, Yusuke Osaki, Yuki Yamamoto, INOUE Soichiroh, Tatsuya Fukumoto, Hiroki Yamazaki, 髙松直子, Shotaro Haji, Wataru Sako and Yuishin Izumi : 筋萎縮性側索硬化症における機能予後予測マーカーとしての尺骨運動神経の遠位潜時, 第55回日本臨床神経生理学会学術大会, Nov. 2025.
12.	Tatsuya Fukumoto, 髙松直子, 谷美紀, Kenta Hanada, Hiroki Yamazaki, Yusuke Osaki, Ryosuke Miyamoto and Yuishin Izumi : 不随意運動の治療におけるポータブル超音波装置の有用性, 第55回日本臨床神経生理学会学術大会サテライトシンポジウム2 第18回神経筋超音波研究会, Nov. 2025.
13.	Kenta Hanada, Shotaro Haji, Koji Fukushima, Hiroki Yamazaki, Yusuke Osaki, N Takamatsu, Koji Fujita and Yuishin Izumi : Aging of amyotrophic lateral sclerosis onset: analysis of cases originating in 2011-2020, 第66回日本神経学会学術大会, May 2025.
14.	Shotaro Haji, Wataru Sako, Koji Fukushima, Kenta Hanada, Yusuke Osaki, Yuki Matsumoto, Masafumi Harada and Yuishin Izumi : QSMを用いた視床下核の面先・磁化率評価は進行性核上性麻痺の診断に有用である, 第64回日本神経学会学術大会, Jun. 2023.
15.	Hiroki Yamazaki, 髙松直子, Koji Fukushima, Kenta Hanada, Yusuke Osaki and Yuishin Izumi : 発症早期ALSの診断における神経超音波を用いた脳神経叢評価の有用性, 第64回日本神経学会学術大会, May 2023.
16.	YAMAKAMI Kei, Kenta Hanada, Yuki Yamamoto, Hiroki Yamazaki, Yusuke Osaki, Naoko Matsui, Koji Fujita and Yuishin Izumi : 尿閉・便秘を呈したフィッシャー症候群の34歳男性例, 第112回日本神経学会中国・四国地方会, Dec. 2022.
17.	Kenta Hanada, Yusuke Osaki, Ryosuke Miyamoto, Shotaro Haji, Hiroyuki Morino and Yuishin Izumi : 新規のMORC2変異を認めたCharcot-Marie-Tooth病2Z型の1例, 第112回日本神経学会中国・四国地方会, Dec. 2022.
18.	Kenta Hanada, Hiroki Yamazaki, 高松直子, Yusuke Osaki and Yuishin Izumi : 神経超音波検査で評価したneurolymphomatosisの1例, 日本臨床神経生理学会第52回学術大会, Nov. 2022.
19.	Kenta Hanada, Yusuke Osaki, Ryosuke Miyamoto, Shotaro Haji, Hiroyuki Morino and Yuishin Izumi : MORC2新規変異を認めたCharcot-Marie-Tooth病2Z型の1例, 第33回日本末梢神経学会学術集会, Sep. 2022.
20.	Kenta Hanada, Yuki Yamamoto, Yusuke Osaki, 島かさ音, MUTO Kohei, Ryosuke Miyamoto, Koji Fujita and Yuishin Izumi : Ocular flutterと体幹優位の運動失調を認めた抗NMDA受容体抗体陽性の若年女性例, 第111回日本神経学会中国・四国地方会, Jun. 2022.
21.	Kenta Hanada, Yuki Yamamoto, Yusuke Osaki, 島かさ音, MUTO Kohei, Ryosuke Miyamoto, Koji Fujita and Yuishin Izumi : Ocular flutterと体幹優位の運動失調を認めた抗NMDA受容体抗体陽性の若年女性例, 第63回日本神経学会学術大会, May 2022.
22.	Kenta Hanada, Yusuke Osaki and Yuishin Izumi : 筋萎縮性側索硬化症の発症年齢はどう変化しているか, 第33回日本老年医学会四国地方会, Jan. 2022.
23.	Kenta Hanada, Yusuke Osaki, 島かさ音, 武藤浩平, 福本竜也, Yuki Yamamoto, 鬼頭秀樹 and Yuishin Izumi : 病院連携により病理解剖を行った筋萎縮性側索硬化症の1例, 第108回日本神経学会中国・四国地方会, Dec. 2020.
24.	Kenta Hanada, Yusuke Osaki, 福本竜也, Naoko Matsui, Yuishin Izumi and 浦岡秀行 : 初期に頭部画像病変を欠くCISが先行し，10年後に診断された多発性硬化症の一例, 第61回日本神経学会学術大会, Aug. 2020.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Search by Researcher Number (61022710)

Designated Assistant Professor : Hanada, Kenta

Research

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Book / Paper

Academic Paper (Judged Full Paper):

Proceeding of Domestic Conference:

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)