徳島大学 / 教育研究者総覧 --- 大櫛祐一郎

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徳島大学 ⟩ 病院 ⟩ 先端医科医療開発研究プロジェクト ⟩
徳島大学 ⟩ 病院 ⟩ 診療科 ⟩ 内科 ⟩ 循環器内科 ⟩
徳島大学 ⟩ 医学部 ⟩ 医学科 ⟩ 器官病態修復医学講座 ⟩ 循環器内科学分野 ⟩

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研究活動

専門分野

研究テーマ

著書・論文

学術論文(審査論文):

1.	Yoshihito Saijyo, Robert Zheng, Yuichiro Ookushi, Yuka Nomura, Yukina Hirata, Hiroaki Inoue, Hirotsugu Yamada, Kenya Kusunose and Masataka Sata : Fully automated artificial intelligence-based echocardiographic analysis for global longitudinal strain monitoring and cancer therapy-related cardiac dysfunction detection in breast cancer patients, European Heart Journal. Digital Health, 7, 6, ztag097, 2026. (要約) Global longitudinal strain (GLS) is essential for the early detection of cancer therapy-related cardiac dysfunction (CTRCD). A fully automated echocardiographic analysis system using artificial intelligence (AI) may improve workflow efficiency in cardio-oncology. We sought to evaluate the feasibility and diagnostic performance of a fully automated AI-based echocardiographic system in breast cancer patients receiving cardiotoxic chemotherapy. In this prospective observational study, patients with breast cancer undergoing anthracyclines and/or HER2-targeted therapy between January 2022 and June 2025 were enrolled. Transthoracic echocardiography was performed at baseline and every 12 weeks. GLS was measured manually by two experts and automatically by a fully automated AI-based analysis system. A total of 92 patients (456 echocardiographic studies) were analysed. AI-derived GLS values were significantly lower than expert measurements (17.7 ± 2.9% vs. 18.4 ± 2.8%, P = 0.007). Correlation and agreement between the two methods were moderate (R = 0.64, intraclass correlation coefficient = 0.63). On linear mixed-effects modelling, longitudinal changes in GLS were not significantly different between methods (P = 0.72). GLS-based CTRCD was detected in 31.5% of patients by experts and 34.8% by AI (P = 0.58), with similar detection timing (P = 0.47). Diagnostic agreement was substantial (κ = 0.68, P < 0.001). The fully automated AI-based echocardiographic system demonstrated acceptable agreement and diagnostic performance for GLS assessment and showed a similar ability to track temporal relative GLS changes and identify CTRCD. However, systemic underestimation of absolute GLS values may contribute to threshold-based classification discordance in borderline cases. (キーワード) 人工知能 (artificial intelligence) / 乳癌 (breast cancer) / Cardiac dysfunction / Chemotherapy / CTRCD / GLS (徳島大学機関リポジトリ) ● Metadata: 2014658 (出版サイトへのリンク) ● Publication site (DOI): 10.1093/ehjdh/ztag097 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 42388419 ● Summary page in Scopus @ Elsevier: 2-s2.0-105043533627 (徳島大学機関リポジトリ: 2014658, DOI: 10.1093/ehjdh/ztag097, PubMed: 42388419, Elsevier: Scopus)

総説・解説:

1.	Yuichiro Ookushi, Tomonori Takahashi and Kenya Kusunose : Echocardiographic evaluation and clinical implications of cardiac remodeling in obesity, Journal of Echocardiography, 24, 69-79, Jan. 2026. (キーワード) Bariatric surgery / Cardiac function / Cardiac structure / 経食道心エコー (transesophageal echocardiography) / GLP-1 RA / 肥満症 (obesity) (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12574-026-00721-6 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-105030391785 (DOI: 10.1007/s12574-026-00721-6, Elsevier: Scopus)

国内講演発表:

1.	平田有紀奈, 野中蓮, 野村侑香, 山口夏美, 西尾進, Robert Zheng, 大櫛祐一郎, 髙橋智紀, 西條良仁, 山田博胤, 楠瀬賢也, 佐田政隆 : 装置非依存AI解析によるGlobal Longitudinal Strain装置間差の検討, 日本心エコー図学会第37回学術集会, 2026年4月.
2.	平田有紀奈, 片岡明久, 野中蓮, 野村侑香, 山口夏美, 西尾進, 大櫛祐一郎, Robert Zheng, 髙橋智紀, 西條良仁, 吉住多聞, 荒川雅崇, 太田隆, 山田博胤, 佐田政隆 : Let's try hands-on! Hand modelで学ぶ三尖弁3Dエコーの第一歩, 日本心エコー図学会第37回学術集会, 2026年4月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

本邦における循環器疾患の癌合併率と予後に与える影響の検討 (研究課題/領域番号: 20K17084 )
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