Tokushima University / Educator and Researcher Directory --- Kinjyo, Soichiro

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Academic Paper (Judged Full Paper):

1.	Soichiro Kinjyo, Yasuhiro Mouri, Wenhua Shao, Satoshi Fukumoto, Eiji Tanaka, Yasusei Kudo and Keiko Miyoshi : Spatiotemporal profiling of Fat family genes highlights Fat2 as a novel marker of outer enamel epithelium and stratum intermedium., Journal of Oral Biosciences, 68, 2, 100766, 2026. (Summary) The Fat gene family, also known as atypical cadherins, contributes to the formation of planar cell polarity, which determines organ shape, size, and polarity. However, their roles in tooth morphogenesis remain unclear. In this study, the aim was to investigate the spatiotemporal expression patterns of Fat1-Fat4 during murine tooth development.Quantitative polymerase chain reaction was performed using total RNA from newborn C57BL/6J murine tissues to determine Fat1-Fat4 expression. In situ hybridization was performed to examine the localization of Fat family transcripts during tooth development from embryonic Day 12.5 to birth. The dental epithelial stem cell line, M3H1, was used as an in vitro differentiation model, and small-interfering-RNA-mediated knockdown of Fat2 was performed to assess its function. Public single-cell RNA-sequence (scRNA-seq) datasets were analyzed to confirm cell-type specificity.All Fat genes were expressed in the teeth, with Fat2 having the highest level among tissues examined. Fat1 was expressed in the epithelial and mesenchymal cells, and Fat2 expression was restricted to the outer enamel epithelium (OEE) and stratum intermedia (SI). Fat3 and Fat4 were expressed in the dental mesenchyme. In M3H1 cells, Fat1 and Fat2 had biphasic expression at undifferentiated and differentiated stages. Fat2 knockdown decreased Sox2 and nephronectin expression, and increased Foxj1 expression. scRNA-seq supported Fat2 specificity in the OEE and SI.Fat genes have cell-type-specific and developmentally regulated expression during tooth development. Among them, Fat2 emerges as a novel marker of OEE and SI, and it may contribute to epithelial identity and differentiation during odontogenesis. (Keyword) Animals / Mice / Mice, Inbred C57BL / Odontogenesis / Dental Enamel / Cell Differentiation / Gene Expression Regulation, Developmental / Biomarkers / Epithelium / Cell Line (Tokushima University Institutional Repository) ● Metadata: 2014135 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.job.2026.100766 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41862271 ● Search Scopus @ Elsevier (PMID): 41862271 ● Search Scopus @ Elsevier (DOI): 10.1016/j.job.2026.100766 (Tokushima University Institutional Repository: 2014135, DOI: 10.1016/j.job.2026.100766, PubMed: 41862271)
2.	KAIHARA Akemi, Shinya Horiuchi, Ryoko Uchida, Sou Shimizu, Emiko Nakaue, TANAKA Mariko, Soichiro Kinjyo, Keiichiro Watanabe, Masahiro Hiasa and Eiji Tanaka : 徳島大学病院矯正歯科にてI期治療を開始し，外科的矯正治療へと移行した患者の実態調査, The Journal of Chu-Shikoku Orthodontic Society, 37, 1, 13-20, 2025.

Proceeding of Domestic Conference:

1.	Soichiro Kinjyo, Eiji Tanaka, Yasusei Kudo and Keiko Miyoshi : 外エナメル上皮細胞および中間層細胞マーカーとしてのFat2 の同定, 第68回歯科基礎医学会学術大会, Sep. 2026.
2.	Toyoaki Takagi, Soichiro Kinjyo and Eiji Tanaka : 下顎第二・第三大臼歯のKissing Molarsを認めた成人患者の1治験例, 第84回日本矯正歯科学会学術大会抄録集, Sep. 2025.
3.	Soichiro Kinjyo, Keiko Miyoshi, NAKAGAWA Mima, Yasusei Kudo and Eiji Tanaka : 歯の形態形成におけるFATファミリー遺伝子の役割, 第84回日本矯正歯科学会学術大会抄録集, Sep. 2025.
4.	NAKAGAWA Mima, 塩屋園玲子, Kaoru Yoshinaga, Soichiro Kinjyo, NAKAGAWA Motosumi, YAMASHITA Akimi, Shinya Horiuchi and Eiji Tanaka : 先端巨大症の高齢患者に対する包括的歯科治療の一治験例, 第68回中・四国矯正歯科学会大会抄録集, Jul. 2025.
5.	KUBOTA Mai, Keiichiro Watanabe, Emiko Nakaue, KAIHARA Akemi, Soichiro Kinjyo, Hirofumi Tenshin, 塩屋園玲子, Masahiro Hiasa, Shinya Horiuchi and Eiji Tanaka : 徳島大学病院矯正歯科における顎変形症患者の顎関節症に関する実態調査, The Japanese Journal of Jaw Deformities, Jun. 2025.