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Research Activity

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Field of Study

Immunology, Molecular Biology

Subject of Study

Development and selection of T lymphocytes in the thymus, Organogenesis of the thymus, Biology of immune system development (immunity, T cells, T lymphocytes, thymus, cell differentiation)

Book / Paper

Book:

1. Izumi Ohigashi, Kenta Kondou and Yousuke Takahama :
免疫生物学(原書第9版) 監訳 笹月健彦,吉開泰信,
Nankodo, 東京都, Mar. 2019.
2. 渡邊 武 and Yousuke Takahama :
Synthetic Immunology,
Springer Japan, Jul. 2016.
3. Izumi Ohigashi and Yousuke Takahama :
Thymocyte-mTEC cross talk for self-tolerance in T cells.,
Elsevier, Apr. 2016.
4. T Boehm and Yousuke Takahama :
Thymic development and selection of T lymphocytes.,
Springer, 2014.
(DOI: 10.1007/978-3-642-40252-4)

Academic Paper (Judged Full Paper):

1. JE Cowan, Yousuke Takahama, A Bhandoola and Izumi Ohigashi :
Postnatal involution and counter-involution of the thymus. Frontiers in Immunology,
Frontiers in Immunology, Vol.11, No.897, 2020.
(DOI: 10.3389/fimmu.2020.00897,   PubMed: 32477366)
2. B Lucas, AJ White, EJ Cosway, SM Parnell, KD James, ND Jones, Izumi Ohigashi, Yousuke Takahama, WE Jenkinson and G Anderson :
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells,
Nature Communications, Vol.11, No.1, 2020.
(DOI: 10.1038/s41467-020-16041-x,   PubMed: 32366944,   Elsevier: Scopus)
3. Hiroyuki Kondo, Takafumi Matsumura, Mari Kaneko, Kenichi Inoue, Hidetaka Kosako, Masahito Ikawa, Yousuke Takahama and Izumi Ohigashi :
PITHD1 is a proteasome-interacting protein essential for male fertilization,
The Journal of Biological Chemistry, Vol.295, No.6, 1658-1672, 2020.
(Tokushima University Institutional Repository: 114611,   DOI: 10.1074/jbc.RA119.011144,   PubMed: 31915251)
4. Jennifer E. Cowan, Justin Malin, Yongge Zhao, Mina O. Seedhom, Christelle Harly, Izumi Ohigashi, Michael Kelly, Yousuke Takahama, Jonathan W. Yewdell, Maggie Cam and Avinash Bhandoola :
Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth,
Nature Communications, Vol.10, No.1, 5498, 2019.
(DOI: 10.1038/s41467-019-13465-y,   PubMed: 31792212,   Elsevier: Scopus)
5. Izumi Ohigashi, Yu Tanaka, Kenta Kondou, Sayumi Fujimori, Hiroyuki Kondo, Amy Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako and Yousuke Takahama :
Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.,
Cell Reports, Vol.29, No.9, 2901-2916.e6, 2019.
(Tokushima University Institutional Repository: 115049,   DOI: 10.1016/j.celrep.2019.10.079,   PubMed: 31775054)
6. Shahina Umme Khanom, Izumi Ohigashi, Sayumi Fujimori, Kenta Kondou, Kensuke Takada and Yousuke Takahama :
TCR affinity for in vivo peptide-induced thymic positive selection fine-tunes TCR responsiveness of peripheral CD8+ T cells,
The Journal of Immunology, Vol.203, No.4, 881-887, 2019.
(Tokushima University Institutional Repository: 113696,   DOI: 10.4049/jimmunol.1900097,   PubMed: 31235550,   Elsevier: Scopus)
7. Emilie J. Cosway, Izumi Ohigashi, Karin Schauble, Sonia M. Parnell, William E. Jenkinson, Sanjiv Luther, Yousuke Takahama and Graham Anderson :
Formation of the intrathymic dendritic cell pool requires CCL21-mediated recruitment of CCR7+ progenitors to the thymus,
The Journal of Immunology, Vol.201, No.2, 516-523, 2018.
(Tokushima University Institutional Repository: 114497,   DOI: 10.4049/jimmunol.1800348,   PubMed: 29784760,   Elsevier: Scopus)
8. Mie Sakata, Izumi Ohigashi and Yousuke Takahama :
Cellularity of Thymic Epithelial Cells in the Postnatal Mouse.,
The Journal of Immunology, Vol.200, No.4, 1382-1388, 2018.
(DOI: 10.4049/jimmunol.1701235,   PubMed: 29298829,   Elsevier: Scopus)
9. Mina Kozai, Yuki Kubo, Tomoya Katakai, Hiroyuki Kondo, Hiroshi Kiyonari, Karin Schaeuble, Sanjiv A. Luther, Naozumi Ishimaru, Izumi Ohigashi and Yousuke Takahama :
Essential role of CCL21 in establishment of central self-tolerance in T cells,
The Journal of Experimental Medicine, Vol.214, No.7, 1925-1935, 2017.
(Tokushima University Institutional Repository: 110168,   DOI: 10.1084/jem.20161864,   PubMed: 28611158)
10. Kenta Kondou, Kensuke Takada and Yousuke Takahama :
Antigen processing and presentation in the thymus: implications for T cell repertoire selection.,
Current Opinion in Immunology, Vol.46, 53-57, 2017.
(DOI: 10.1016/j.coi.2017.03.014,   PubMed: 28477557,   Elsevier: Scopus)
11. Andrew Sornborger, Jie Li, Cullen Timmons, Floria Lupu, Jonathan Eggenschwiler, Yousuke Takahama and Nancy R. Manley :
MiCASA is a new method for quantifying cellular organization.,
Nature Communications, Vol.8, 15619, 2017.
(DOI: 10.1038/ncomms15619,   PubMed: 28555660)
12. Izumi Ohigashi, Yuki Ohte, Kazuya Setoh, Hiroshi Nakase, Akiko Maekawa, Hiroshi Kiyonari, Yoko Hamazaki, Miho Sekai, Tetsuo Sudo, Yasuharu Tabara, Hiromi Sawai, Yosuke Omae, Rika Yuliwulandari, Yasuhito Tanaka, Masashi Mizokami, Hiroshi Inoue, Masanori Kasahara, Nagahiro Minato, Katsushi Tokunaga, Keiji Tanaka, Fumihiko Matsuda, Shigeo Murata and Yousuke Takahama :
A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production,
JCI Insight, Vol.2, No.10, 2017.
(Tokushima University Institutional Repository: 113736,   DOI: 10.1172/jci.insight.93664,   PubMed: 28515360)
13. Kensuke Takada, Kenta Kondou and Yousuke Takahama :
Generation of Peptides That Promote Positive Selection in the Thymus,
The Journal of Immunology, Vol.198, No.6, 2215-2222, 2017.
(DOI: 10.4049/jimmunol.1601862,   PubMed: 28264997)
14. Uddin Myn Muhammad, Izumi Ohigashi, Ryo Motosugi, Tomomi Nakayama, Mie Sakata, Jun Hamazaki, Yasumasa Nishito, Immanuel Rode, Keiji Tanaka, Tatsuya Takemoto, Shigeo Murata and Yousuke Takahama :
Foxn1-5t transcriptional axis controls CD8+ T-cell production in the thymus.,
Nature Communications, Vol.8, 14419, 2017.
(Tokushima University Institutional Repository: 110920,   DOI: 10.1038/ncomms14419,   PubMed: 28176764,   Elsevier: Scopus)
15. Izumi Ohigashi, Mina Kozai and Yousuke Takahama :
Development and developmental potential of cortical thymic epithelial cells,
Immunological Reviews, Vol.271, No.1, 10-22, 2016.
(Tokushima University Institutional Repository: 113737,   DOI: 10.1111/imr.12404,   PubMed: 27088904,   Elsevier: Scopus)
16. CE Mayer, S Zuklys, S Zhanybekova, Izumi Ohigashi, HY Teh, SN Sansom, N Shikama-Dorn, K Hafen, IC Macaulay, ME Deadman, CP Ponting, Yousuke Takahama and GA Hollander :
Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla,
European Journal of Immunology, Vol.46, No.4, 846-856, 2016.
(DOI: 10.1002/eji.201545995,   PubMed: 26694097)
17. Izumi Ohigashi and Yousuke Takahama :
Thymocyte-mTEC cross talk for self-tolerance in T cells,
Encyclopedia of Immunology, Vol.1, 263-267, 2016.
(Elsevier: Scopus)
18. Izumi Ohigashi and Yousuke Takahama :
Flow Cytometry Analysis of Thymic Epithelial Cells and Their Subpopulations,
Methods in Molecular Biology, Vol.1323, 65-73, 2016.
(DOI: 10.1007/978-1-4939-2809-5_5,   PubMed: 26294398)
19. Izumi Ohigashi, Saulius Zuklys, Mie Sakata, Carlos E. Mayer, Yoko Hamazaki, Nagahiro Minato, Georg A Hollander and Yousuke Takahama :
Adult thymic medullary epithelium is maintained and regenerated by lineage-restricted cells rather than bipotent progenitors,
Cell Reports, Vol.13, No.7, 1432-1443, 2015.
(Tokushima University Institutional Repository: 113738,   DOI: 10.1016/j.celrep.2015.10.012,   PubMed: 26549457,   Elsevier: Scopus)
20. Kensuke Takada, Francois Van Laethem, Yan Xing, Kazuyuki Akane, Haruhiko Suzuki, Shigeo Murata, Keiji Tanaka, Stephen C Jameson, Alfred Singer and Yousuke Takahama :
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells,
Nature Immunology, Vol.16, No.10, 1069-1076, 2015.
(DOI: 10.1038/ni.3237,   PubMed: 26301566,   Elsevier: Scopus)
21. Tomomi Sano, Misaki Iwashita, Nagayasu Nagayasu, Akiko Yamashita, Takanori Shinjo, Atsushi Hashikata, Tomoichiro Asano, Akifumi Kushiyama, Naozumi Ishimaru, Yousuke Takahama and Fusanori Nishimura :
Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling.,
Obesity, Vol.23, No.7, 1460-1471, 2015.
(DOI: 10.1002/oby.21127,   PubMed: 26097021,   Elsevier: Scopus)
22. Katsuhiro Sasaki, Kensuke Takada, Yuki Ohte, Hiroyuki Kondo, Hiroyuki Sorimachi, Keiji Tanaka, Yousuke Takahama and Shigeo Murata :
Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells.,
Nature Communications, Vol.6, 7484, 2015.
(DOI: 10.1038/ncomms8484,   PubMed: 26099460,   Elsevier: Scopus)
23. Kensuke Takada and Yousuke Takahama :
Positive-selection-inducing self-peptides displayed by cortical thymic epithelial cells.,
Advances in Immunology, Vol.125, 87-110, 2015.
(DOI: 10.1016/bs.ai.2014.09.003,   PubMed: 25591465,   Elsevier: Scopus)
24. L Nuno Alves, Yousuke Takahama, Izumi Ohigashi, R Ana Ribeiro, Song Baik, Graham Anderson and E William Jenkinson :
Serial progression of cortical and medullary thymic epithelial microenvironments.,
European Journal of Immunology, Vol.44, No.1, 16-22, 2014.
(DOI: 10.1002/eji.201344110,   PubMed: 24214487,   Elsevier: Scopus)
25. Kensuke Takada, Izumi Ohigashi, Michiyuki Kasai, Hiroshi Nakase and Yousuke Takahama :
Development and function of cortical thymic epithelial cells.,
Current Topics in Microbiology and Immunology, Vol.373, 1-17, 2014.
(DOI: 10.1007/82_2013_322,   PubMed: 23612989,   Elsevier: Scopus)
26. Izumi Ohigashi and Yousuke Takahama :
CCRL1 marks heterogeneity in cortical and medullary thymic epithelial cells.,
European Journal of Immunology, Vol.44, No.10, 2872-2875, 2014.
(DOI: 10.1002/eji.201445091,   PubMed: 25216053,   Elsevier: Scopus)
27. Togoo Khongorzul, Yousuke Takahama and Kensuke Takada :
Alpha-smooth muscle actin expression identifies subpopulations of lymph node non-hematopoietic cells.,
Biochemical and Biophysical Research Communications, Vol.449, No.2, 241-247, 2014.
(Tokushima University Institutional Repository: 106277,   DOI: 10.1016/j.bbrc.2014.05.023,   PubMed: 24845380,   Elsevier: Scopus)
28. Kouta Yano, Christine Carter, Naofumi Yoshida, Takaya Abe, Akiko Yamada, Takeshi Nitta, Naozumi Ishimaru, Kensuke Takada, W Geoffrey Butcher and Yousuke Takahama :
Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.,
European Journal of Immunology, Vol.44, No.2, 561-572, 2014.
(Tokushima University Institutional Repository: 105966,   DOI: 10.1002/eji.201343750,   PubMed: 24510501,   Elsevier: Scopus)
29. Naoko Matsui, Izumi Ohigashi, Keijirou Tanaka, Mie Sakata, Takahiro Furukawa, Yasushi Nakagawa, Kazuya Kondo, Tetsuya Kitagawa, Sumimasa Yamashita, Yoshiko Nomura, Yousuke Takahama and Ryuji Kaji :
Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia.,
Journal of Neuroimmunology, Vol.269, No.1-2, 56-61, 2014.
(DOI: 10.1016/j.jneuroim.2014.01.011,   PubMed: 24556356,   Elsevier: Scopus)
30. A Joy Williams, Jingjing Zhang, Hyein Jeon, Takeshi Nitta, Izumi Ohigashi, David Klug, J Michael Kruhlak, Baishakhi Choudhury, O Susan Sharrow, Larry Granger, Anthony Adams, A Michael Eckhaus, Rhiannon S Jenkinson, R Ellen Richie, E Ronald Gress, Yousuke Takahama and J Richard Hodes :
Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.,
The Journal of Immunology, Vol.192, No.2, 630-640, 2014.
(DOI: 10.4049/jimmunol.1302550,   PubMed: 24337745,   Elsevier: Scopus)
31. Rhiannon S Jenkinson, A Joy Williams, Hyein Jeon, Jingjing Zhang, Takeshi Nitta, Izumi Ohigashi, Michael Kruhlak, Saulius Zuklys, Susan Sharrow, Anthony Adams, Larry Granger, Yongwon Choi, Ulrich Siebenlist, A Gail Bishop, A Georg Hollander, Yousuke Takahama and J Richard Hodes :
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.110, No.52, 21107-21112, 2013.
(DOI: 10.1073/pnas.1314859111,   PubMed: 24324158)
32. Taisuke Nakayama, Hirotsugu Kurobe, Noriko Sugasawa, Hajime Kinoshita, Mayuko Higashida, Yuki Matsuoka, Yasushi Yoshida, Yoichiro Hirata, Mie Sakata, Mark Maxfield, Yousuke Takahama, Masataka Sata, Toshiaki Tamaki, Tetsuya Kitagawa and Shuhei Tomita :
Role of macrophage-derived Hypoxia-Inducible Factor (HIF)-1 as a mediator of vascular remodeling,
Cardiovascular Research, Vol.99, No.4, 705-715, 2013.
(Tokushima University Institutional Repository: 105898,   DOI: 10.1093/cvr/cvt146,   PubMed: 23752975)
33. L Jerrod Bryson, V Ann Griffith, Bernard Iii Hughes, Fumi Saito, Yousuke Takahama, R Ellen Richie and R Nancy Manley :
Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus.,
PLoS ONE, Vol.8, No.6, e65196, 2013.
(DOI: 10.1371/journal.pone.0065196,   PubMed: 23750244)
34. Izumi Ohigashi, Saulius Zuklys, Mie Sakata, E Carlos Mayer, Saule Zhanybekova, Shigeo Murata, Keiji Tanaka, A Georg Holländer and Yousuke Takahama :
Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.110, No.24, 9885-9890, 2013.
(DOI: 10.1073/pnas.1301799110,   PubMed: 23720310)
35. Enkhsaikhan Lkhagvasuren, Mie Sakata, Izumi Ohigashi and Yousuke Takahama :
Lymphotoxin receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells.,
The Journal of Immunology, Vol.190, No.10, 5110-5117, 2013.
(Tokushima University Institutional Repository: 105886,   DOI: 10.4049/jimmunol.1203203,   PubMed: 23585674)
36. Hirotsugu Kurobe, Takashi Tominaga, Mikio Sugano, Yasunobu Hayabuchi, Yoshiyasu Egawa, Yousuke Takahama and Tetsuya Kitagawa :
Complete but not partial thymectomy in early infancy reduces T-cell-mediated immune response: three-year tracing study after pediatric cardiac surgery.,
Journal of Thoracic and Cardiovascular Surgery, Vol.145, No.3, 656-662, 2013.
(DOI: 10.1016/j.jtcvs.2012.12.015,   PubMed: 23312343)
37. Takeshi Nitta, Izumi Ohigashi and Yousuke Takahama :
The development of T lymphocytes in fetal thymus organ culture.,
Methods in Molecular Biology, Vol.946, 85-102, 2013.
(DOI: 10.1007/978-1-62703-128-8_6,   PubMed: 23179827)
38. Yasushi Nakagawa, Ohigashi Izumi, Nitta Takeshi, Sakata Mie, Tanaka Keiji, Murata Shigeo, Kanagawa Osami and Yousuke Takahama :
Thymic nurse cells provide microenvironment for secondary T cell receptor rearrangement in cortical thymocytes,
Proceedings of the National Academy of Sciences of the United States of America, Vol.109, No.50, 20572-20577, 2012.
(DOI: 10.1073/pnas.1213069109,   PubMed: 23188800)
39. Saulius Zuklys, E Carlos Mayer, Saule Zhanybekova, E Heather Stefanski, Gretel Nusspaumer, Jason Gill, Thomas Barthlott, Stephane Chappaz, Takeshi Nitta, James Dooley, Ruben Nogales-Cadenas, Yousuke Takahama, Daniela Finke, Adrian Liston, R Bruce Blazar, Alberto Pascual-Montano and A Georg Holländer :
MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.,
The Journal of Immunology, Vol.189, No.8, 3894-3904, 2012.
(DOI: 10.4049/jimmunol.1200783,   PubMed: 22972926)
40. Graham Anderson and Yousuke Takahama :
Thymic epithelial cells: working class heroes for T cell development and repertoire selection,
Trends in Immunology, Vol.33, No.6, 256-263, 2012.
(DOI: 10.1016/j.it.2012.03.005,   PubMed: 22591984)
41. NM Roberts, AJ White, WE Jenkinson, G Turchinovich, K Nakamura, DR Withers, FM McConnell, GE Desanti, C Benezech, SM Parnell, AF Cunningham, M Paolino, J Penninger, K Simon, T Nitta, Izumi Ohigashi, Yousuke Takahama, JH Caamano, AC Hayday, PJ Lane, EJ Jenkinson and G Anderson :
Rank signaling links the development of invariant γδ T cell progenitors and Aire+ medullary epithelium.,
Immunity, Vol.36, No.3, 427-437, 2012.
(DOI: 10.1016/j.immuni.2012.01.016,   PubMed: 22425250)
42. Yu Lei and Yousuke Takahama :
XCL1 and XCR1 in the immune system,
Microbes and Infection, Vol.14, No.3, 262-267, 2012.
(DOI: 10.1016/j.micinf.2011.10.003,   PubMed: 22100876)
43. Yousuke Takahama, Kensuke Takada, Shigeo Murata and Keiji Tanaka :
Beta5t-containing thymoproteasome: specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells.,
Current Opinion in Immunology, Vol.24, No.1, 92-98, 2012.
(DOI: 10.1016/j.coi.2012.01.006,   PubMed: 22285892)
44. Naozumi Ishimaru, Akiko Yamada, Takeshi Nitta, Rieko Arakaki, Martin Lipp, Yousuke Takahama and Yoshio Hayashi :
CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy.,
The American Journal of Pathology, Vol.180, No.1, 199-208, 2012.
(DOI: 10.1016/j.ajpath.2011.09.027,   PubMed: 22067914)
45. Yousuke Takahama :
Medullary interplay for central tolerance,
Blood, Vol.118, No.9, 2380-2381, 2011.
(DOI: 10.1182/blood-2011-05-351734,   PubMed: 21885606)
46. Izumi Ohigashi, Takeshi Nitta, E Lkhagvasuren, H Yasuda and Yousuke Takahama :
Effects of RANKL on the thymic medulla,
European Journal of Immunology, Vol.41, No.7, 1822-1827, 2011.
(DOI: 10.1002/eji.201141480,   PubMed: 21706487)
47. A Ripen Mat, Takeshi Nitta, S Murata, K Tanaka and Yousuke Takahama :
Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t,
European Journal of Immunology, Vol.41, No.5, 1278-1287, 2011.
(DOI: 10.1002/eji.201041375,   PubMed: 21469133)
48. Yu Lei, Adiratna Mat Ripen, Naozumi Ishimaru, Izumi Ohigashi, Takashi Nagasawa, Lukas T. Jeker, Michael R. Bösl, Georg A. Holländer, Yoshio Hayashi, Rene Waal de Malefyt, Takeshi Nitta and Yousuke Takahama :
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development,
The Journal of Experimental Medicine, Vol.208, No.2, 383-394, 2011.
(DOI: 10.1084/jem.20102327,   PubMed: 21300913)
49. Takeshi Nitta, Izumi Ohigashi, Yasushi Nakagawa and Yousuke Takahama :
Cytokine crosstalk for thymic medulla formation,
Current Opinion in Immunology, Vol.23, No.2, 190-197, 2011.
(DOI: 10.1016/j.coi.2010.12.002,   PubMed: 21194915)
50. Izumi Ohigashi, Yuki Yamasaki, Tsukasa Hirashima and Yousuke Takahama :
Identification of the Transgenic Integration Site in Immunodeficient tgϵ26 Human CD3ϵ Transgenic Mice,
PLoS ONE, Vol.5, No.12, e14391, 2010.
(DOI: 10.1371/journal.pone.0014391,   PubMed: 21203507)
51. Kyoko Hidaka, Takeshi Nitta, Ryo Sugawa, J Robert Schwartz, Takashi Amagai, Sachiko Nitta, Yousuke Takahama and Takayuki Morisaki :
Differentiation of Pharyngeal Endoderm and Derivatives from Mouse Embryonic Stem Cells.,
Stem Cells and Development, Vol.19, No.11, 1735-1743, 2010.
(DOI: 10.1089/scd.2009.0466,   PubMed: 20230268,   Elsevier: Scopus)
52. Andrea J. White, Kyoko Nakamura, William E. Jenkinson, Manoj Saini, Charles Sinclair, Benedict Seddon, Parth Narendran, Klaus Pfeffer, Takeshi Nitta, Yousuke Takahama, Jorge H. Caamano, Peter J. L. Lane, Eric J. Jenkinson and Graham Anderson :
Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells,
The Journal of Immunology, Vol.185, No.8, 4769-4776, 2010.
(DOI: 10.4049/jimmunol.1002151,   PubMed: 20861360)
53. Yousuke Takahama, Takeshi Nitta, Adiratna MatRipen, Sachiko Nitta, Shigeo Murata and Keiji Tanaka :
Role of thymic-cortex-specific self-peptides in positive selection of T cells.,
Seminars in Immunology, Vol.22, No.5, 287-293, 2010.
(DOI: 10.1016/j.smim.2010.04.012,   PubMed: 20510627)
54. Kensuke Takada and Yousuke Takahama :
Another zinc finger in the pie of CD4-CD8 lineage choice,
Nature Immunology, Vol.11, No.5, 370-371, 2010.
(DOI: 10.1038/ni0510-370,   PubMed: 20404849)
55. Noriko Tosa, Atsushi Iwai, Taku Tanaka, Tomoka Kumagai, Takeshi Nitta, Satoko Chiba, Masahiro Maeda, Yousuke Takahama, Toshimitsu Uede and Tadaaki Miyazaki :
Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction.,
Biochemical and Biophysical Research Communications, Vol.395, No.3, 356-360, 2010.
(DOI: 10.1016/j.bbrc.2010.04.018,   PubMed: 20381457)
56. Naoko Matsui, Shunya Nakane, Fumi Saitou, Izumi Ohigashi, Yasushi Nakagawa, Hirotsugu Kurobe, Hiromitsu Takizawa, Takao Mitsui, Kazuya Kondo, Tetsuya Kitagawa, Yousuke Takahama and Ryuji Kaji :
Undiminished regulatory T cells in the thymus of myathenia gravis patients,
Neurology, Vol.74, No.10, 816-820, 2010.
(DOI: 10.1212/WNL.0b013e3181d31e47,   PubMed: 20211905)
57. Hirotsugu Kurobe, Masahisa Urata, Masaki Ueno, Masaaki Ueki, Shiro Ono, Yuki Izawa-Ishizawa, Yayoi Fukuhara, Yu Lei, Adiratna Mat Ripen, Tamotsu Kanbara, Ken-ichi Aihara, Keisuke Ishizawa, Masashi Akaike, Frank J. Gonzalez, Toshiaki Tamaki, Yousuke Takahama, Masanori Yoshizumi, Tetsuya Kitagawa and Shuhei Tomita :
Role of Hypoxia-Inducible Factor 1α in T Cells as a Negative Regulator in Development of Vascular Remodeling,
Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.30, No.2, 210-217, 2010.
(DOI: 10.1161/ATVBAHA.109.192666,   PubMed: 20007912)
58. Naozumi Ishimaru, Takeshi Nitta, Rieko Arakaki, Akiko Yamada, Martin Lipp, Yousuke Takahama and Yoshio Hayashi :
In situ Patrolling of Regulatory T cells is Essential for Protecting Autoimmune Exocrinopathy,
PLoS ONE, Vol.5, No.1, e8588, 2010.
(DOI: 10.1371/journal.pone.0008588,   PubMed: 20052419)
59. Takeshi Nitta, Shigeo Murata, Katsuhiro Sasaki, Hideki Fujii, Adiratna Mat Ripen, Naozumi Ishimaru, Shigeo Koyasu, Keiji Tanaka and Yousuke Takahama :
Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells.,
Immunity, Vol.32, No.1, 29-40, 2010.
(DOI: 10.1016/j.immuni.2009.10.009,   PubMed: 20045355)
60. Takeshi Nitta, Sachiko Nitta, Yu Lei, Martin Lipp and Yousuke Takahama :
CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens,
Proceedings of the National Academy of Sciences of the United States of America, Vol.106, No.40, 17129-17133, 2009.
(DOI: 10.1073/pnas.0906956106,   PubMed: 19805112)
61. Y Lei, C Liu, F Saito, Y Fukui and Yousuke Takahama :
Role of DOCK2 and DOCK180 in fetal thymus colonization,
European Journal of Immunology, Vol.39, No.10, 2695-2702, 2009.
(DOI: 10.1002/eji.200939630,   PubMed: 19728314)
62. N Iwanami, M Okada, VQ Hoa, Y Seo, H Mitani, T Sasaki, N Shimizu, H Kondoh, M Furutani-Seiki and Yousuke Takahama :
Ethylnitrosourea-induced thymus-defective mutants identify roles of KIAA1440, TRRAP, and SKIV2L2 in teleost organ development,
European Journal of Immunology, Vol.39, No.9, 2606-2616, 2009.
(DOI: 10.1002/eji.200939362,   PubMed: 19670383)
63. Andrea P. Martin, Tatjana Marinkovic, Claudia Canasto-Chibuque, Rauf Latif, Jay C. Unkeless, Terry F. Davies, Yousuke Takahama, Glaucia C. Furtado and Sergio A. Lira :
CCR7 deficiency in NOD mice leads to thyroiditis and primary hypothyroidism,
The Journal of Immunology, Vol.183, No.5, 3073-3080, 2009.
(DOI: 10.4049/jimmunol.0900275,   PubMed: 19675158)
64. Yousuke Takahama, T Saito, H Kawamoto, M Itoi, RL Boyd, A Chidgey, R Zamoyska, GA Hollander, G Anderson, N Taylor, HT Petrie and J Nikolich-Zugich :
The global thymus network: past, present, and future,
Trends in Immunology, Vol.30, No.5, 191-192, 2009.
(DOI: 10.1016/j.it.2009.03.005,   PubMed: 19362055)
65. DA Sultana, Shuhei Tomita, M Hamada, Y Iwanaga, Y Kitahama, NV Khang, S Hirai, Izumi Ohigashi, S Nitta, T Amagai, S Takahashi and Yousuke Takahama :
Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development,
Blood, Vol.113, No.13, 2976-2987, 2009.
(DOI: 10.1182/blood-2008-06-164921,   PubMed: 19164599)
66. Magali Irla, Ste´phanie Hugues, Jason Gill, Takeshi Nitta, Yu Hikosaka, Ifor R Williams, Franc¸ois-Xavier Hubert, Hamish S Scott, Yousuke Takahama, Georg A Holla¨nder and Walter Reith :
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.,
Immunity, Vol.29, No.3, 451-463, 2008.
(DOI: 10.1016/j.immuni.2008.08.007,   PubMed: 18799151)
67. Taishin Akiyama, Yusuke Shimo, Hiromi Yanai, Junwen Qin, Daisuke Ohshima, Yuya Maruyama, Yukiko Asaumi, Juli Kitazawa, Hiroshi Takayanagi, Josef Penninger, Mitsuru Matsumoto, Takeshi Nitta, Yousuke Takahama and Jun-ichiro Inoue :
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.,
Immunity, Vol.29, No.3, 423-437, 2008.
(DOI: 10.1016/j.immuni.2008.06.015,   PubMed: 18799149)
68. Yu Hikosaka, Takeshi Nitta, Izumi Ohigashi, Kouta Yano, Naozumi Ishimaru, Yoshio Hayashi, Mitsuru Matsumoto, Koichi Matsuo, Josef M Penninger, Hiroshi Takayanagi, Yoshifumi Yokota, Hisakata Yamada, Yasunobu Yoshikai, Jun-ichiro Inoue, Taishin Akiyama and Yousuke Takahama :
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.,
Immunity, Vol.29, No.3, 438-450, 2008.
(DOI: 10.1016/j.immuni.2008.06.018,   PubMed: 18799150)
69. N Iwanami, T Higuchi, Y Sasano, T Fujiwara, V Hoa, M Okada, S Talukder, S Kunimatsu, J Li, F Saito, C Bhattacharya, A Matin, T Sasaki, N Shimizu, H Mitani, H Himmelbauer, A Momoi, H Kondoh, M Furutani-Seiki and Yousuke Takahama :
WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development.,
PLoS Genetics, Vol.4, No.8, e1000171, 2008.
(DOI: 10.1371/journal.pgen.1000171,   PubMed: 18769712)
70. Yousuke Takahama, K Tanaka and S Murata :
Modest cortex and promiscuous medulla for thymic repertoire formation.,
Trends in Immunology, Vol.29, No.6, 251-255, 2008.
(DOI: 10.1016/j.it.2008.03.003,   PubMed: 18472300)
71. S Murata, Yousuke Takahama and K Tanaka :
Thymoproteasome: probable role in generating positively selecting peptides,
Current Opinion in Immunology, Vol.20, No.2, 192-196, 2008.
(DOI: 10.1016/j.coi.2008.03.002,   PubMed: 18403190)
72. Takeshi Nitta, Shigeo Murata, Tomoo Ueno, Keiji Tanaka and Yousuke Takahama :
Thymic microenvironments for T-cell repertoire formation.,
Advances in Immunology, Vol.99, 59-94, 2008.
(DOI: 10.1016/S0065-2776(08)00603-2,   PubMed: 19117532)
73. Hiroko Hagiwara, Kazumi Sawakami-Kobayashi, Midori Yamamoto, Shoji Iwasaki, Mika Sugiura, Hatsumi Abe, Sumiko Kunihiro-Ohashi, Kumiko Takase, Noriko Yamane, Kaoru Kato, Renkon Son, Michihiro Nakamura, Osamu Segawa, Mamiko Yoshida, Masafumi Yohda, Hideji Tajima, Masato Kobori, Yousuke Takahama, Mitsuo Itakura and Masayuki Machida :
Development of an automated SNP analysis method using a paramagnetic beads handling robot.,
Biotechnology and Bioengineering, Vol.98, No.2, 420-428, 2007.
(DOI: 10.1002/bit.21380,   PubMed: 17335059)
74. Jie Li, Norimasa Iwanami, VQ Quynh Hoa, Makoto Furutani-Seiki and Yousuke Takahama :
Noninvasive intravital imaging of thymocyte dynamics in medaka.,
The Journal of Immunology, Vol.179, No.3, 1605-1615, 2007.
(PubMed: 17641027)
75. WE Jenkinson, SW Rossi, SM Parnell, WW Agace, Yousuke Takahama, EJ Jenkinson and G Anderson :
Chemokine receptor expression defines heterogeneity in the earliest thymic migrants.,
European Journal of Immunology, Vol.37, No.8, 2090-2096, 2007.
(DOI: 10.1002/eji.200737212,   PubMed: 17578846)
76. S Murata, K Sasaki, T Kishimoto, S Niwa, H Hayashi, Yousuke Takahama and K Tanaka :
Regulation of CD8+ T cell development by thymus-specific proteasomes.,
Science, Vol.316, No.5829, 1349-1353, 2007.
(DOI: 10.1126/science.1141915,   PubMed: 17540904)
77. S Rossi, LT Jeker, Tomoo Ueno, S Kuse, MP Keller, A Zuklys, A Gudkov, Yousuke Takahama, W Krenger, BR Blazar and GA Hollander :
Keratinocyte growth factor enhances post-natal T cell development via improvement in proliferation and function of thymic epithelial cells,
Blood, Vol.109, No.9, 3803-3811, 2007.
(DOI: 10.1182/blood-2006-10-049767,   PubMed: 17213286)
78. Takeshi Nitta and Yousuke Takahama :
The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins,
Trends in Immunology, Vol.28, No.2, 58-65, 2007.
(DOI: 10.1016/j.it.2006.12.002,   PubMed: 17196432)
79. T. Yasuda, T. Kuwabara, H. Nakano, K. Aritomi, T. Onodera, M. Lipp, Yousuke Takahama and T Kakiuchi :
Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells,
Blood, Vol.109, No.2, 449-456, 2007.
(DOI: 10.1182/blood-2006-04-018101,   PubMed: 16973962)
80. Cunlan Liu, Fumi Saito, Zhijie Liu, Yu Lei, Shoji Uehara, Paul Love, Martin Lipp, Shunzo Kondo, Nancy Manley and Yousuke Takahama :
Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization.,
Blood, Vol.108, No.8, 2531-2539, 2006.
(DOI: 10.1182/blood-2006-05-024190,   PubMed: 16809609)
81. Takeshi Nitta, Mariam Nasreen, Takafumi Seike, Atsushi Goji, Izumi Ohigashi, Tadaaki Miyazaki, Tsutomu Ohta, Masamoto Kanno and Yousuke Takahama :
IAN family critically regulates survival and development of T lymphocytes,
PLoS Biology, Vol.4, No.4, e103-e115, 2006.
(DOI: 10.1371/journal.pbio.0040103,   PubMed: 16509771)
82. Shuhei Tomita, Shin-ichi Maekawa, Mustafizur Rahman, Fumi Saito, Ryoichi Kizu, Keiko Tohi, Tomoo Ueno, Hiroshi Nakase, Frank Gonzalez, Kazuichi Hayakawa, Takashi Korenaga and Yousuke Takahama :
Thymic involution produced by diesel exhaust particles and their constituents in mice,
Toxicological and Environmental Chemistry, Vol.88, 113-124, 2006.
(DOI: 10.1080/02772240500475128,   Elsevier: Scopus)
83. Hirotsugu Kurobe, Cunian Liu, Tomoo Ueno, Fumi Saito, Izumni Ohigashi, Natalle Seach, Rieko Arakaki, Yoshio Hayashi, Tetsuya Kitagawa, Martin Lipp, Richard L. Boyd and Yousuke Takahama :
CCR7-Dependent Cortex-to-Medulla Migration of Positively Selected Thymocytes Is Essential for Establishing Central Tolerance,
Immunity, Vol.24, No.2, 165-177, 2006.
(DOI: 10.1016/j.immuni.2005.12.011,   PubMed: 16473829)
84. Georg Hollander, Jason Gill, Saulus Zuklys, Norimasa Iwanami, Cunlan Liu and Yousuke Takahama :
Cellular and molecular events during early thymus development.,
Immunological Reviews, Vol.209, No.1, 28-46, 2006.
(DOI: 10.1111/j.0105-2896.2006.00357.x,   PubMed: 16448532)
85. Yousuke Takahama :
Journey through the thymus: stromal guides for T-cell development and selection.,
Nature Reviews. Immunology, Vol.6, No.2, 127-135, 2006.
(DOI: 10.1038/nri1781,   PubMed: 16491137)
86. Daniel HD Gray, Tomoo Ueno, Ann P Chidgey, Mark Malin, Gabrielle L Goldberg, Yousuke Takahama and Richard L Boyd :
Controlling the thymic microenvironment,
Current Opinion in Immunology, Vol.17, No.2, 137-143, 2005.
(DOI: 10.1016/j.coi.2005.02.001,   PubMed: 15766672)
87. Noriyuki Kuroda, Tasuku Mitani, Naoki Takeda, Naozumi Ishimaru, Rieko Arakaki, Yoshio Hayashi, Yoshimi Bando, Keisuke Izumi, Takeshi Takahashi, Takashi Nomura, Shimon Sakaguchi, Tomoo Ueno, Yousuke Takahama, Daisuke Uchida, Shijie Sun, Fumiko Kajiura, Yasuhiro Mouri, Hongwei Han, Akemi Matsushima, Gen Yamada and Mitsuru Matsumoto :
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice,
The Journal of Immunology, Vol.174, No.4, 1862-1870, 2005.
(DOI: 10.3410/f.1024264.287833,   PubMed: 15699112)
88. Tomoo Ueno, Cunlan Liu, Takeshi Nitta and Yousuke Takahama :
Development of T-lymphocytes in mouse fetal thymus organ culture.,
Methods in Molecular Biology, Vol.290, 117-134, 2005.
(DOI: 10.1385/1-59259-838-2:117,   PubMed: 15361659)
89. Cunlan Liu, Tomoo Ueno, Sachiyo Kuse, Fumi Saito, Takeshi Nitta, Luca Piali, Hideki Nakano, Terutaka Kakiuchi, Martin Lipp, Georg A. Hollander and Yousuke Takahama :
The role of CCL21 in recruitment of T-precursor cells to fetal thymi,
Blood, Vol.105, No.1, 31-39, 2005.
(DOI: 10.1182/blood-2004-04-1369,   PubMed: 15358618)
90. Tomoo Ueno, Fumi Saito, Daniel H.D. Gray, Sachiyo Kuse, Kunio Hieshima, Hideki Nakano, Terutaka Kakiuchi, Martin Lipp, Richard L. Boyd and Yousuke Takahama :
CCR7 signals are essential for cortex-to-medulla migration of developing thymocytes.,
The Journal of Experimental Medicine, Vol.200, No.4, 493-505, 2004.
(DOI: 10.1084/jem.20040643,   PubMed: 15302902)
91. Norimasa Iwanami, Yousuke Takahama, Sanae Kunimatsu, Jie Li, Rie Takei, Yuko Ishikura, Hiroshi Suwa, Katsutoshi Niwa, Takao Sasado, Chikako Morinaga, Akihito Yasuoka, Tomonori Deguchi, Yukihiro Hirose, Hiroki Yoda, Thorsten Henrich, Osamu Ohara, Hisato Kondoh and Makoto Furutani-Seiki :
Mutations affecting thymus organogenesis in medaka, Oryzias latipe.,
Mechanisms of Development, Vol.121, No.7-8, 779-789, 2004.
(DOI: 10.1016/j.mod.2004.03.020)
92. Fumiko Kajiura, Shijie Sun, Takashi Nomura, Keisuke Izumi, Tomoo Ueno, Yoshimi Bando, Noriyuki Kuroda, Hongwei Han, Yi Li, Akemi Matsushima, Yousuke Takahama, Shimon Sakaguchi, Tasuku Mitani and Mitsuru Matsumoto :
NF-κB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner,
The Journal of Immunology, Vol.172, No.4, 2067-2075, 2004.
(PubMed: 14764671)
93. MA Sheard, C Liu and Yousuke Takahama :
Developmental status of CD4-CD8+ and CD4+CD8- thymocytes with medium expression of CD3,
European Journal of Immunology, Vol.34, No.1, 25-35, 2004.
(DOI: 10.1002/eji.200324460,   PubMed: 14971027)
94. Shuhei Tomita, Hou-Bo Jiang, Tomoo Ueno, Satoshi Takagi, Keiko Tohi, Shin-ichi Maekawa, Akira Miyatake, Aizo Furukawa, Frank J. Gonzalez, Junji Takeda, Yoshiyuki Ichikawa and Yousuke Takahama :
T Cell-Specific Disruption of Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Gene Causes Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Thymic Involution,
The Journal of Immunology, Vol.171, No.8, 4113-4120, 2003.
(PubMed: 14530333)
95. Mariam Nasreen, Tomoo Ueno, Fumi Saito and Yousuke Takahama :
In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla.,
The Journal of Immunology, Vol.171, No.7, 3394-3400, 2003.
(PubMed: 14500633)
96. Hiroshi Nakase, Yousuke Takahama and Yoshiko Akamatsu :
Effect of CpG methylation on RAG1/RAG2 reactivity: implications of direct and indirect mechanism for controlling V(D)J cleavage.,
EMBO Reports, Vol.4, No.8, 774-780, 2003.
(DOI: 10.1038/sj.embor.embor904,   PubMed: 12897800)
97. Y Akamatsu, R Monroe, DD Dudley, SK Elkin, F Gartner, SR Talukder, Yousuke Takahama, FW Alt, CH Bassing and MA Oettinger :
Deletion of the RAG2 C-terminus leads to impaired lymphoid development in mice.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.100, No.3, 1209-1214, 2003.
(DOI: 10.1073/pnas.0237043100)
98. Tomoo Ueno, Kyoko Hara, Melissa Swope Willis, Mark A. Malin, Uta E. Hoepken, Daniel H.D. Gray, Kouji Matsushima, Martin Lipp, Timothy A. Singer, Richard L. Boyd, Osamu Yoshie and Yousuke Takahama :
Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.,
Immunity, Vol.16, No.2, 205-218, 2002.
(DOI: 10.1016/S1074-7613(02)00267-4,   PubMed: 11869682)
99. M Tada, Yousuke Takahama, K Abe, N Nakatsuji and T Tada :
Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells.,
Current Biology, Vol.11, No.19, 1553-1558, 2001.
(DOI: 10.1016/S0960-9822(01)00459-6,   PubMed: 11591326,   Elsevier: Scopus)
100. Shigetoshi Sano, Yousuke Takahama, Takehiko Sugawara, Hiroshi Kosaka, Satoshi Itami, Kunihiko Yoshikawa, Jun-ichi Miyazaki, Willen van Ewijk and Junji Takeda :
Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival.,
Immunity, Vol.15, No.2, 261-273, 2001.
101. N Masuyama, K Oishi, Y Mori, Tomoo Ueno, Yousuke Takahama and Y Gotoh :
Akt inhibits the orphan nuclear receptor Nur77 and T cell apoptosis,
The Journal of Biological Chemistry, Vol.276, No.35, 32799-32805, 2001.
(DOI: 10.1074/jbc.M105431200,   PubMed: 11438550)
102. Mirdori Kaneta, Masatake Osawa, Kazuhiro Sudo, Hiromitsu Nakauchi, Andrew G. Farr and Yousuke Takahama :
A role for Pref-1 and HES-1 in thymocyte development.,
The Journal of Immunology, Vol.164, No.1, 256-264, 2000.
103. Yousuke Takahama, Kazuhito Ohishi, Yayoi Tokoro, Takehiko Sugawara, Yasuhide Yoshimura, Masaru Okabe, Taroh Kinoshita and Junji Takeda :
Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene.,
Eur. J. Immunol., Vol.28, No.07, 2159-2166, 1998.
104. T. Sugawara, T. Moriguchi, E. Nishida and Yousuke Takahama :
Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.,
Immunity, Vol.9, 565-574, 1998.
105. Y. Tokoro, T. Sugawara, H. Yaginuma, H. Nakauchi, C. Terhorst, B. Wang and Yousuke Takahama :
A mouse carrying genetic defect in the choice between T and B lymphocytes.,
The Journal of Immunology, Vol.161, 4591-4598, 1998.
106. T. Sugawara, V. Bartolo Di, T. Miyazaki, H. Nakauchi, O. Acuto and Yousuke Takahama :
An improved retroviral gene transfer technique demonstrates inhibition of CD4-CD8- thymocyte development by kinase-inactive ZAP-70.,
The Journal of Immunology, Vol.161, 2888-2894, 1998.
107. S. Sagara, K. Sugaya, Y. Tokoro, S. Tanaka, H. Takano, H. Kodama, T. Nakauchi and Yousuke Takahama :
B220 expression by T lymphoid progenitor cells in mouse fetal liver.,
The Journal of Immunology, Vol.158, No.2, 666-676, 1997.
108. Yousuke Takahama and Hiromitsu Nakauchi :
Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells.,
The Journal of Immunology, Vol.157, No.4, 1508-1513, 1996.
(PubMed: 8759732)
109. Yousuke Takahama, H. Suzuki, S. K. Katz, J. M. Grusby and A. Singer :
Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC.,
Nature, Vol.371, No.6492, 67-70, 1994.
(DOI: 10.1038/371067a0,   PubMed: 7915400)
110. Yousuke Takahama, J. J. Letterio, H. Suzuki, G. A. Farr and A. Singer :
Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor β.,
The Journal of Experimental Medicine, Vol.179, No.5, 1495-1506, 1994.
(DOI: 10.1084/jem.179.5.1495,   PubMed: 8163934)
111. Yousuke Takahama and Alfred Singer :
Research Article: Post-transcriptional regulation of early T cell development by T cell receptor signals.,
Science, Vol.258, No.5087, 1456-1462, 1992.
(DOI: 10.1126/science.1439838,   PubMed: 1439838)
112. Yousuke Takahama, Elizabeth W Shores and Alfred Singer :
Negative selection of precursor thymocytes before their differentiation into CD4+CD8+ cells.,
Science, Vol.258, No.5082, 653-656, 1992.
(DOI: 10.1126/science.1357752,   PubMed: 1357752)

Review, Commentary:

1. Andrea Cossarizza, (200 authors), Yousuke Takahama and (34 authors) :
Guidelines for the use of flow cytometry and cell sorting in immunological studies.,
European Journal of Immunology, Vol.47, No.10, 1584-1797, Oct. 2017.
(DOI: 10.1002/eji.201646632,   PubMed: 29023707)
2. Yousuke Takahama, Izumi Ohigashi, Song Baik and Graham Anderson :
Generation of diversity in thymic epithelial cells,
Nature Reviews. Immunology, Vol.17, No.5, 295-305, May 2017.
(DOI: 10.1038/nri.2017.12,   PubMed: 28317923)
3. Kensuke Takada and Yousuke Takahama :
胸腺プロテアソームを介したCD8+ T細胞の正の選択,
Clinical Immunology & Allergology, Vol.65, No.5, 506-512, Mar. 2016.
4. Kensuke Takada and Yousuke Takahama :
胸腺プロテアソーム依存的な正の選択はCD8+T細胞の抗原応答性を至適化する,
Experimental Medicine, Vol.34, No.3, 446-449, Jan. 2016.
5. Izumi Ohigashi and Yousuke Takahama :
T細胞の自己寛容を確立する胸腺髄質微小環境,
自己免疫疾患の発症機構と治療 実験医学増刊号, 30-36, 2015.
6. 近藤 博之 and Yousuke Takahama :
Tリンパ球の分化と胸腺の役割,
病理と臨床, Vol.33, 696-702, 2015.
7. Kensuke Takada and Yousuke Takahama :
T細胞のレパトア形成における胸腺皮質上皮の役割,
Clinical Immunology & Allergology, Vol.63, 507-513, 2015.
(CiNii: 40020504861)
8. Kensuke Takada and Yousuke Takahama :
T細胞分化におけるチェックポイント,
Inflammation & Immunology, Vol.23, 3-9, 2015.
9. Yasushi Nakagawa and Yousuke Takahama :
胸腺ナース細胞はT細胞二次選択の場を提供する,
Journal of Clinical and Experimental Medicine, Vol.248, 549-550, 2014.
10. 香西 美奈 and Yousuke Takahama :
Thymus : development and function,
Science of the Living Body, Vol.65, No.3, 226-232, May 2014.
(CiNii: 40020133055)
11. Yousuke Takahama :
一次リンパ器官,胸腺,近交系マウス,ナース細胞,免疫監視,免疫トレランス,免疫プロテアソームの9項目,
岩波生物学辞典第5版, 2013.
12. Kensuke Takada and Yousuke Takahama :
獲得免疫,
カラー版 内科学, 374-379, Jul. 2012.
13. Yousuke Takahama :
T lymphocyte development and selection in the thymic microenvironments,
Seikagaku, Vol.84, No.3, 177-182, Mar. 2012.
(PubMed: 22568069,   CiNii: 10030564188)
14. Yousuke Takahama and 湊 長博 :
Analysis and synthesis of multi-dimentional immune organ network,
Seikagaku, Vol.84, No.3, 161-162, Mar. 2012.
(PubMed: 22568066,   CiNii: 10030564100)
15. Izumi Ohigashi and Yousuke Takahama :
XCL1と胸腺におけるnTregの生成,
Infection, Inflammation & Immunity, Vol.41, 60-62, 2011.
16. Izumi Ohigashi and Yousuke Takahama :
Thymic cortical epithelial cells specific expression of thymoproteasome,
Clinical immunology & allergology, Vol.56, No.3, 232-237, Sep. 2011.
(CiNii: 40019017856)
17. Naoko Matsui, Takeshi Nitta and Yousuke Takahama :
Development of the thymus and immune system,
Brain and Nerve = Shinkei kenkyū no shinpo, Vol.63, No.7, 679-684, Jul. 2011.
(PubMed: 21747137,   CiNii: 40018922074,   Elsevier: Scopus)
18. Takeshi Nitta and Yousuke Takahama :
NF-kB経路と胸腺髄質形成,
免疫疾患, 467-473, 2011.
19. Takeshi Nitta and Yousuke Takahama :
胸腺プロテアソームによるCD8+ T細胞のレパトア形成,
Journal of Clinical and Experimental Medicine, Vol.234, No.12, 1129-1130, Sep. 2010.
20. Naoko Matsui and Yousuke Takahama :
神経系免疫の特徴,
Clinical Neuroscience, Vol.28, No.2, 142-145, Feb. 2010.
21. Naoko Matsui and Yousuke Takahama :
免疫学の基礎:神経系免疫の特徴,
Clinical Neuroscience, Vol.28, 142-145, 2010.
22. Takeshi Nitta and Yousuke Takahama :
CD8+ T細胞のレパートリー形成と胸腺プロテアソーム,
臨床免疫・アレルギー科, 2010.
23. Takeshi Nitta, Tomoo Ueno and Yousuke Takahama :
Cytokines and chemokines that regulate the microenvironment of the thymic medulla,
Experimental Medicine, Vol.27, No.11, 1764-1769, Jul. 2009.
24. Takeshi Nitta and Yousuke Takahama :
胸腺の髄質形成,
感染・炎症・免疫, Vol.39, No.2, 26-35, 2009.
25. Yousuke Takahama :
T細胞の分化と機能,
免疫学最新イラストレイテッド改訂第2版, 101-118, 2009.
26. 斉藤 ふみ, 新田 幸子 and Yousuke Takahama :
共焦点レーザー顕微鏡を用いた凍結組織切片 の免疫蛍光多重染色解析法,
注目のバイオ実験シリーズ改訂版抗体実験マニュ アル, 31-39, 2008.
27. Tomoo Ueno and Yousuke Takahama :
胸腺におけるT細胞の正負選択,
Medical Bio, Vol.5, 39-44, 2008.
28. Yousuke Takahama :
中枢性免疫寛容の分子理解,
免疫応答と免疫病態の統合的分子理解に向けて, 155-160, Nov. 2007.
29. Takeshi Nitta and Yousuke Takahama :
胸腺クロストークシグナルと髄質形成,
Annual Review 2008 免疫, 162-168, 2007.
30. Takeshi Nitta and Yousuke Takahama :
中枢性トレランスと自己免疫疾患,
日本臨床免疫学会会誌, Vol.29, 8-15, 2006.
31. Takeshi Nitta and Yousuke Takahama :
T細胞レパトア形成と胸腺微小環境,
実験医学増刊・免疫研究最前線2007, Vol.24, 35-41, 2006.
32. Takeshi Nitta and Yousuke Takahama :
T,
臨床免疫・アレルギー科, Vol.46, 474-478, 2006.
33. 新田 剛 and Yousuke Takahama :
中枢性トレランスと自己免疫疾患,
臨床免疫学会会誌, Vol.29, 8-15, 2006.
34. Tomoo Ueno and Yousuke Takahama :
ケモカイン受容体CCR7と胸腺内Tリンパ球動態,
免疫 2006, 54-58, 2006.
35. Yousuke Takahama :
自己免疫疾患の基礎:中枢性トレランスの異常,
最新医学, Vol.60, No.746, 30(1278)-37(1285), Jun. 2005.
36. Tomoo Ueno and Yousuke Takahama :
免疫細胞の発生・再生,
キーワードで理解する発生・再生イラストマップ, 75-83, 2005.
37. Yousuke Takahama :
自己免疫疾患の基礎:中枢性トレランスの異常,
最新医学増刊号 免疫と疾患(後篇)自己免疫と疾患, 30-37, 2005.
38. Tomoo Ueno and Yousuke Takahama :
胸腺内T細胞分化に伴う細胞移動のケモカイン制御,
Journal of Clinical and Experimental Medicine, Vol.213, No.11, 985-988, 2005.
39. Yousuke Takahama :
免疫寛容,
予防医学事典, 6-8, 2005.
40. Yousuke Takahama :
中枢性トレランス,
日本臨床増刊号 臨床免疫学 (上) 基礎研究の進歩と最新の臨床, 377-380, 2005.
41. Tomoo Ueno and Yousuke Takahama :
CCR7ケモカインによる成熟胸腺細胞の髄質移入制御,
臨床免役, Vol.42, 603-608, 2005.
42. 岩波 礼将 and Yousuke Takahama :
メダカを用いた胸腺器官発生機構の解析,
免疫 2005, 57-64, 2005.
43. 岩波 礼将 and Yousuke Takahama :
胸腺の器官形成-モデル生物によるアプローチ,
Annual Review 免疫 2005, 155-161, 2005.
44. Norimasa Iwanami and Yousuke Takahama :
メダカを用いた胸腺器官発生機構の解析,
免疫 2005, 57-64, Dec. 2004.
45. Yousuke Takahama :
T細胞の分化と機能,
免疫学最新イラストレイテッド, 77-94, Aug. 2003.
46. Takeshi Nitta and Yousuke Takahama :
T細胞選択を制御する分子シグナル,
Clinical Immunology, Vol.39, 201-208, 2003.
47. Takeshi Nitta and Yousuke Takahama :
中枢性免疫寛容の分子機序-自己寛容の成立に関する分子機序,
分子細胞治療, Vol.2, 3-7, 2003.
48. Yousuke Takahama :
T細胞とB細胞への分化方向を決定する分子要因,
Clinical Immunology, Vol.36, 71-75, Jul. 2001.

Proceeding of International Conference:

1. Izumi Ohigashi, Yu Tanaka, Kenta Kondou, Sayumi Fujimori, Amy C. Palin, Hiroyuki Kondo, Hidetaka Kosako and Yousuke Takahama :
Trans-omics impact of thymoproteasome in cortical thymic epithelial cells,
ThymE: T cell and thymus biology, May 2019.
2. Izumi Ohigashi and Yousuke Takahama :
Human PSMB11 polymorphisms that affect thymoproteasome processing and CD8+ T cell generation,
8th THYMOZ, Mar. 2018.
3. Uddin Myn, Izumi Ohigashi and Yousuke Takahama :
Foxn1-b5t transcriptional axis controls CD8+ T-cell production in the thymus,
IMMUNOLOGY 2017, AAI Annual Meeting, May 2017.
4. Yousuke Takahama :
Mechanisms for positive selection of CD8+ T cells,
2017 FIMSA Advanced Course, Apr. 2017.
5. Yousuke Takahama :
cTEC-dependent positive selection of CD8+ T cells,
7th International Workshop of Kyoto T Cell Conference, Mar. 2017.
6. Kondo Hiroyuki, Izumi Ohigashi, Kozai Mina, Kubo Yuki, Katakai Tomoya, Luther A. Sanjiv and Yousuke Takahama :
Essential role of CCL21 in establishment of central self-tolerance in T cells,
7th International Workshop of Kyoto T Cell Conference, Mar. 2017.
7. Izumi Ohigashi, Ohte Yuki, Setoh Kazuya, Matsuda Fumihiko, Murata Shigeo and Yousuke Takahama :
A human Psmb11 polymorphism affects molecular processing of thymoproteasome and thymic production of CD8+ T cells,
7th International Workshop of Kyoto T Cell Conference, Mar. 2017.
8. Sayumi Fujimori, Izumi Ohigashi, Tatsuya Takemoto, Yousuke Takahama and Takada Shinji :
Activation of Wnt/β-catenin signaling in thymic epithelial progenitors,
7th International Workshop of Kyoto T Cell Conference, Kyoto, Mar. 2017.
9. Kozai Mina, Izumi Ohigashi and Yousuke Takahama :
CCL21 regulates T-cell self-tolerance in thymic medulla,
11th International Symposium of The Institute Network Frontiers in Biomedical Sciences, Jan. 2017.
10. Izumi Ohigashi, Uddin Myn, Tatsuya Takemoto and Yousuke Takahama :
Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus,
11th International Symposium of The Institute Network Frontiers in Biomedical Sciences, Jan. 2017.
11. Yousuke Takahama :
How the thymic medulla attracts thymocytes for the establishment of selftolerance,
2016 NCI Thymus Symposium, Dec. 2016.
12. Yousuke Takahama :
T-cell development & selection,
The 13th FIMSA Advanced Immunology Course, チャンディーガール(インド), Mar. 2016.
13. Izumi Ohigashi and Yousuke Takahama :
Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus,
The Fifth Bizan Immunology symposium, 徳島県徳島市, Mar. 2016.
14. Yousuke Takahama :
T cell formation in thymus microenvironments,
Asia CORD 2015 in KOBE, 神戸市, May 2015.
15. Yousuke Takahama :
Thymus epithelium conditions antigen responsiveness in CD8+T cells,
1st international Venice Thymus Meeting, Apr. 2015.
16. Yousuke Takahama :
Synthetic immunology,
The 1st meeting of Thymus Translational Research, 下高井郡, Feb. 2015.
17. Izumi Ohigashi and Yousuke Takahama :
Adult thymus medullary epithelium is maintained and regenerated by lineage restricted cells rather than bipotent progenitors,
The Fourth BIZAN Immunology Symposium at University of TokushimaImmune System Development, Deviation, and Regulation, Jan. 2015.
18. Yousuke Takahama :
Positive selection conditions TCR responsiveness in T cells,
The Fourth BIZAN Immunology Symposium at University of TokushimaImmune System Development, Deviation, and Regulation, Jan. 2015.
19. Kensuke Takada and Yousuke Takahama :
Thymoproteasome-dependent MHC class I-associated peptide motifs contribute to positive selection of CD8 T cells,
The 24th Hot Spring Harbor International Symposium Recent Advance in Immunology and Inflammation, Nov. 2014.
20. Kensuke Takada and Yousuke Takahama :
Positive selection conditions antigen responsiveness of CD8 T cells,
The 7th ThymOZ International Conference, Apr. 2014.
21. Izumi Ohigashi, Zuklys Saulius, Hollander Georg and Yousuke Takahama :
mTECs derived from embryonic and postnatal beta5t+ progenitors,
The 7th ThymOZ International Conference, Apr. 2014.
22. Yousuke Takahama :
Thymus microenvironments for T cell repertoire formation,
The 1st international Nano.BioMedical conference, Feb. 2014.
23. Izumi Ohigashi and Yousuke Takahama :
Development and developmental potential of 5t-expressing thymic epithelial cells,
The Third Bizan Immunology Symposium at The University of Tokushima (BISUT3) "Immune System Development, Deviation, and Regulation", Feb. 2014.
24. Kensuke Takada and Yousuke Takahama :
What is the positive selection for?,
The Third Bizan Immunology Symposium at The University of Tokushima (BISUT3) "Immune System Development, Deviation, and Regulation", Feb. 2014.
25. Taisuke Nakayama, Hirotsugu Kurobe, Noriko Sugasawa, Hajime Kinoshita, Yasushi Yoshida, Yoichiro Hirata, Mie Sakata, Mark Webster Maxfield, Michio Shimabukuro, Yousuke Takahama, Masataka Sata, Toshiaki Tamaki, Tetsuya Kitagawa and Shuhei Tomita :
Macrophage-Specific Hypoxia-Inducible Factor (HIF)-1-Deficient Mice Suppress the Vascular Remodeling and Regulate M2 Macrophage Polarization,
American Heart Association AHA 2013, Nov. 2013.
26. Yousuke Takahama and Izumi Ohigashi :
Serial development of cortical and medullary thymic epithelia,
Fourth Synthetic Immunology WorkshopEngineering in Immunity, Nov. 2013.
27. Yousuke Takahama :
The thymic microenvironments that shape T cell repertoire,
15th International Congress of Immunology, Aug. 2013.
28. Kensuke Takada and Yousuke Takahama :
Functional conditioning of CD8 T cells by thymoproteasome-dependent positive selection.,
6th International Workshop of Kyoto T Cell Conference, Kyoto, Jul. 2013.
29. Naoko Matsui, Izumi Ohigashi, Yousuke Takahama and Ryuji Kaji :
Increased Hassalls corpuscles in myasthenia gravis patients carrying thymic hyperplasia,
Myasthenia 2013, Paris, Jul. 2013.
30. Yousuke Takahama and Izumi Ohigashi :
Development and developmental potential of 5t-expressing thymic epithelial cells,
KTCC 2013 International Workshop on T Lymphocytes, Jun. 2013.
31. Kensuke Takada and Yousuke Takahama :
Functional conditioning of CD8 T cells by thymoproteasome-dependent positive selection,
KTCC 2013 International Workshop on T Lymphocytes, Jun. 2013.
32. Lkhagvasuren Enkhsaikhan, Sakata Mie, Izumi Ohigashi and Yousuke Takahama :
Lymphotoxin receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells,
KTCC 2013 International Workshop on T Lymphocytes, Jun. 2013.
33. Manley R Nancy, Li Jie, Timmons Cullen, Yousuke Takahama and Sornborger Andrew :
CASA: A new method for quantifying tissue organization,
KTCC 2013 International Workshop on T Lymphocytes, Jun. 2013.
34. Kensuke Takada and Yousuke Takahama :
Functional conditioning of CD8 T cells by thymoproteasome-dependent positive selection.,
100th American Association of Immunologists Annual Meeting, May 2013.
35. Yousuke Takahama :
Attacking the endocrine system: what is AIRE doing?,
Society for Endocrinology BES 2013, Mar. 2013.
36. Kensuke Takada and Yousuke Takahama :
Thymoproteasome-dependent positive selection conditions cytokine reactivity of mature CD8 T cells.,
The Second Immunology Symposium of The University of Tokushima Immune System Development, Deviation, and Regulation, Jan. 2013.
37. Yousuke Takahama :
Development and developmental potential of cTECs,
The Second Immunology Symposium of The University of TokushimaImmune Development, Deviation, and Regulation, Jan. 2013.
38. Yousuke Takahama :
Thymic microenvironments for T cell repertoire formation,
Centennial of Hashimoto Disease International Symposium, Dec. 2012.
39. Takai C., Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama :
Microarray analysis for CD classification of thymic epithelial cell subpopulations,
3rd International Thymic Malignancy Interest Group Annual Meeting, Nov. 2012.
40. Yousuke Takahama :
T cell repertoire formation in the thymus,
3rd International Thymic Malignancy Interest Group Annual Meeting, Nov. 2012.
41. Taisuke Nakayama, Hirotsugu Kurobe, Noriko Sugasawa, Hajime Kinoshita, Mayuko Higashida, Yuki Matsuoka, Yasushi Yoshida, Yoichiro Hirata, Mie Sakata, Mark Webster Maxfield, Yousuke Takahama, Masataka Sata, Toshiaki Tamaki, Tetsuya Kitagawa and Shuhei Tomita :
Role of Macrophage-derived Hif-1a as a Mediator of Vascular Remodeling,
American Heart Association Scientific Sessions 2012, Nov. 2012.
42. Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, Nomura Yoshiko, Yousuke Takahama and Ryuji Kaji :
Increased Hassalls Corpuscles In Myasthenia Gravis Patients Carrying Thymic Hyperplasia,
11th International congress of neuroimmunology, Nov. 2012.
43. Yousuke Takahama :
Aire+ thymic medullary epithelial cells originate from beta 5t+ progenitor cells,
ThymUS International Conference, Nov. 2012.
44. Enkhsaikhan Lkhagvasuren and Yousuke Takahama :
Heterogenesity in medullary thymic epithelial cells A2147G is the most prevalent mutation among clarithromycin resistant,
3rd International Conference Advances in Microbiology and Immunology, ウランバートル, Jun. 2012.
45. Yousuke Takahama :
T lymphocyte repertoire formation in thymic microenvironments,
3rd International Conference Advances in Microbiology and Immunology, ウランバートル, Jun. 2012.
46. Michiyuki Kasai and Yousuke Takahama :
Towards the establishment of functionally competent thymic epithelial cell lines,
The 3rd Workshop of Synthetic Immunology 2012, 11, May 2012.
47. Michiyuki Kasai and Yousuke Takahama :
TOWARDS THE ESTABLISHMENT OF FUNCTIONALLY COMPETENT THYMIC EPITHELIAL CELL LINES,
The 3rd Workshop of Synthetic Immunology, Kyoto, May 2012.
48. Yousuke Takahama :
The thymic cortex and positive selection of T cells,
Thymus Symposium, May 2012.
49. Yousuke Takahama :
Thymic cortical epithelial cells for T cell repertoire formation,
The 99th AAI Annual Meeting IMMUNOLOGY, Boston, May 2012.
50. Kensuke Takada and Yousuke Takahama :
Functional abnormality of peripheral CD8 T cells in beta5t-deficient mice,
The 99th American Association of Immunologists Annual Meeting, May 2012.
51. Kensuke Takada and Yousuke Takahama :
Functional abnormality of peripheral CD8 T cells in β5t-deficient mice,
The 99th AAI Annual Meeting IMMUNOLOGY, Boston, May 2012.
52. Hirotsugu Kurobe, takashi Tominaga, Masahisa Urata, Mikio Sugano, Yoichiro Hirata, Miho Sakata, Yasunobu Hayabuchi, Takashi Kitaichi, Takaki Hori, Yoshiyasu Egawa, Yousuke Takahama and Tetsuya Kitagawa :
Complete thymectomy during cardiac surgery in early infancy reduces circulating T cells and vaccination-induced IgG responses: a study of 3-year-tracing,
AATS2012 92th annual meeting, San Francisco, Apr. 2012.
53. Yousuke Takahama :
T lymphocyte repertoire formation in thymic microenvironments,
FIMSA 2012, Mar. 2012.
54. Yousuke Takahama :
Thymic microenvironment and repertoire selection of T cells,
New Horizons in the Immune System, Feb. 2012.
55. Yousuke Takahama :
Molecular Biology of Thymic Microenvironments,
The 2011 CSI/FIMSA (3rd CSI) Advanced Course on Immunology, Dec. 2011.
56. Kensuke Takada and Yousuke Takahama :
Memory-like phenotype of CD8 T cells in 5t-deficient mice,
EUThyme-Rolduc Meeting, May 2011.
57. Yousuke Takahama :
Cytokine circuit that regulates T cell repertoire formation,
JSICR-MMCB2011, Osaka, May 2011.
58. Saulius Zuklys, E. Carlos Mayer, Saule Zhanybekova, Takeshi Nitta, Stephan Chappaz, Yousuke Takahama, Daniela Finke and A. Georg Holländer :
Dicer-dependent miRNA are required for the postnatal maintenance of the thymic epithelial microenvironment,
EUThyme-Rolduc Meeting, May 2011.
59. Yousuke Takahama :
Chemokine regulation of central tolerance,
EUThyme-Rolduc Meeting, May 2011.
60. Graham Anderson, Natalie Roberts, Andrea White, William Jenkinson, David Withers, Gleb Turchinovich, Adrian Hayday, Josef Penninger, Takeshi Nitta, Yousuke Takahama, Peter Lane and Eric Jenkinson :
Maturation Of Intrathymic Dendritic Epidermal T-cell Progenitors And Aire-Expressing Medullary Epithelial Cells Are Reciprocally Linked,
EUThyme-Rolduc Meeting, May 2011.
61. Yousuke Takahama :
Mechanisms to establish self-tolerance in the thymic medulla,
Lymphocyte development and autoimmunity, CHIP meeting, Lund(Sweden), Mar. 2011.
62. Yousuke Takahama :
Thymic microenvironments that shape T lymphocyte repertoire,
ESF-JSPS Frontier Science Conference for Young Researchers Cutting Edge Immunology and its Clinical Application, Hulshort(The Netherlands), Mar. 2011.
63. Izumi Ohigashi, Takeshi Nitta, ENOMOTO Tetsuro, TOMIMORI Toshiya, YASUDA Hisataka and Yousuke Takahama :
RANKL PROMOTES THYMIC MEDULLA FORMATION,
The 2nd Workshop of Synthetic Immunology, Kyoto, Dec. 2010.
64. Yousuke Takahama :
T-CELL REPERTOIRE FORMATION IN THE THYMUS,
Cold Spring Harbor Asia Conferences -Frontiers of Immunology in Health and Diseases-, Suzhou(China), Nov. 2010.
65. Yousuke Takahama :
Thymic microenvironments shaping T-cell repertoire,
8th German-Japanese Symposium on Regulation of Immune Response and Disease, Cuxhaven(Germany), Sep. 2010.
66. Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki, Yousuke Takahama and Yoshio Hayashi :
Critical Signaling Pathway via CCR7 of Foxp3+CD25+CD4+ Regulatory T Cells for the Egress from Lymph Nodes,
international immunology, Aug. 2010.
67. Takeshi Nitta, Sachiko Nitta and Yousuke Takahama :
Role of cortical thymic epithelial cells in positive selection of T cells.,
14th International Congress of Immunology, Kobe, Aug. 2010.
68. Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki, Yousuke Takahama and Yoshio Hayashi :
Critical signaling pathway via CCR7 of Foxp3+CD25+CD4+ regulatory T cells for the egress from lymph nodes.,
第14回国際免疫学会, Kobe, Aug. 2010.
69. Hirotsugu Kurobe, Takashi Tominaga, Mikio Sugano, Masahisa Urata, Takaki Hori, Yoshiyasu Egawa, Yousuke Takahama and Tetsuya Kitagawa :
Complete thymectomy at neonatal cardiac surgery reduces circulating T cells,
14th International Congress of Immunology 2010, Kobe, Aug. 2010.
70. Matsui Naoko, Nakane Shunya and Yousuke Takahama :
Undiminished Regulatory T Cells in the Thymus of Myasthenia Gravis Patients,
14th International Congress of Immunology, Kobe, Aug. 2010.
71. Zuklys Saulius, E Carlos, Zhanybekova Saule Mayer, Takeshi Nitta, Chappaz Stephan, Gill Jason, Yousuke Takahama, Finke Daniela and Holländer A. Georg :
Dicer is required for the postnatal maintenance of the thymic epithelial microenvironment,
14th International Congress of Immunology, Kobe, Aug. 2010.
72. Lei Yu, Takeshi Nitta, Ripen Mat Adiratna, Malefyt de Waal Rene and Yousuke Takahama :
Aire regulates XCL1-mediated medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells,
14th International Congress of Immunology, Kobe, Aug. 2010.
73. Yousuke Takahama :
Thymic microenvironments that shape T cell repertoire,
14th International Congress of Immunology, Kobe, Aug. 2010.
74. Yousuke Takahama :
XCL1 regulates medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells,
Gordon Research Conferences, Lucca(Italy), Jun. 2010.
75. Takeshi Nitta, Shigeo Murata, Katsuhiro Sasaki, Hideki Fujii, Shigeo Koyasu, Keiji Tanaka and Yousuke Takahama :
Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells,
ThymOz International Conference, Gladstone, Queensland, Australia, Mar. 2010.
76. Takeshi Nitta, Sachiko Nitta and Yousuke Takahama :
Revisiting thymic nurse cell,
The 5th International Workshop of Kyoto T Cell Conference 2009, Kyoto, Japan, Jun. 2009.
77. Takeshi Nitta, Yu Hikosaka and Yousuke Takahama :
RANKL produced by positively selected thymocytes fosters Aire+ mTEC,
ThymUS 2008 International Conference, San Juan, Puerto Rico, USA, Nov. 2008.
78. Takeshi Nitta and Yousuke Takahama :
IAN5 regulates T-cell survival,
ThymOz International Workshop on T Lymphocytes, Heron Island, Australia, Apr. 2006.
79. Takeshi Nitta, Mariam Nasreen, Takafumi Seike, Atsushi Goji and Yousuke Takahama :
IAN family critically regulates T lymphocyte development,
ThymuS 2004, San Juan, Puerto Rico, USA, Nov. 2004.
80. Hiroko Hagiwara, Kazumi Sawakami, Midori Yamamoto, Hideji Tajima, Shouji Iwasaki, Masato Kobori, Mitsuo Itakura, Yousuke Takahama and Masayuki Machida :
Development of an automated system for the analysis of SNPs using the MagtrationR technology,
6. Genome Sequencing and Analysis Conference, San Diego, 2001.

Proceeding of Domestic Conference:

1. Izumi Ohigashi, Hidetaka Kosako and Yousuke Takahama :
Trans-omics impact of thymoproteasome in cortical thymic epithelial cells,
第42回日本分子生物学会年会, Dec. 2019.
2. Sayumi Fujimori, Izumi Ohigashi, Yousuke Takahama and 高田 慎治 :
Fine-tuning of the β-catenin-dependent signaling in mouse thymic epithelial cells is required for thymic development,
第42回日本分子生物学会年会, Dec. 2019.
3. 近藤 博之, 松村 貴史, Hidetaka Kosako, 伊川 正人, Yousuke Takahama and Izumi Ohigashi :
新規プロテアソーム会合因子PITHD1は精子形成を制御する,
第42回日本分子生物学学会年会, Dec. 2019.
4. 近藤 博之, 松村 貴史, Hidetaka Kosako, 伊川 正人, Yousuke Takahama and Izumi Ohigashi :
プロテアソームに会合する新規分子PITHD1の機能解析,
第41回日本分子生物学会年会, Nov. 2018.
5. Sayumi Fujimori, Izumi Ohigashi, Takada Shinji and Yousuke Takahama :
Enforced activation of β-catenin signaling in mouse thymic epithelial cells induces thymic dysplasia,
The 41st Annual Meeting of the Molecular Biology Society of Japan, Nov. 2018.
6. Yamamoto Yohhei, Naoko Matsui, Kazuya Kondo, Izumi Ohigashi, Yousuke Takahama, Nakagawa Hidewaki, Yuishin Izumi and Ryuji Kaji :
Analysis of human thymic epithelial cells,
第59回日本神経学会学術大会, May 2018.
7. Izumi Ohigashi, Naozumi Ishimaru, Katakai Tomoya and Yousuke Takahama :
Essential role of CCL21 in establishment of central tolerance in T cells,
第40回 日本分子生物学会年会, Dec. 2017.
8. Sayumi Fujimori, Izumi Ohigashi, Tatsuya Takemoto, 高田 慎治 and Yousuke Takahama :
マウス胸腺皮質上皮細胞亜集団におけるWnt/β-cateninシグナル経路の活性化,
第40回日本分子生物学会年会, Dec. 2017.
9. Naoko Matsui, Izumi Ohigashi, Myn Muhammad Uddin, Kaito Sasaka, Yohhei Yamamoto, Takahiro Furukawa, Kazuya Kondo, 中川 英刀, Ryuji Kaji and Yousuke Takahama :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第29回日本神経免疫学会学術集会, Oct. 2017.
10. Naoko Matsui, Izumi Ohigashi, Yamamoto Yohei, Kazuya Kondo, Yousuke Takahama and Ryuji Kaji :
Approach for analysis of human thymic epithelial cells,
XX World Congress of Neurology, Sep. 2017.
11. Uddin Myn, Izumi Ohigashi and Yousuke Takahama :
Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus,
第46回日本免疫学会学術集会, Dec. 2016.
12. Izumi Ohigashi, Tatsuya Takemoto and Yousuke Takahama :
胸腺におけるCD8+ T細胞生成を制御するFoxn1結合シス制御領域の同定,
第39回日本分子生物学会年会, Dec. 2016.
13. Sayumi Fujimori, Izumi Ohigashi, Tatsuya Takemoto, Yousuke Takahama and 高田 慎治 :
マウス胸腺上皮細胞におけるWnt/β-cateninシグナル経路の時空間的活性化,
第39回日本分子生物学会年会, Dec. 2016.
14. Yousuke Takahama :
生体防御のかなめ「胸腺」の形成と機能,
知の拠点セミナー, Sep. 2016.
15. 金 喜栄, Naoko Matsui, Izumi Ohigashi, 古川 貴大, Yousuke Takahama and Ryuji Kaji :
ヒト胸腺を用いた胸腺上皮細胞解析への試み,
第57日本神経学会学術大会, 367, May 2016.
16. Myn Uddin, Izumi Ohigashi and Yousuke Takahama :
Foxn1-binding cis-regulatory element for optimal CD8+ T cell production in the thymus,
第26回 Kyoto T cell Conference, May 2016.
17. Kensuke Takada and Yousuke Takahama :
次世代シーケンサを用いた胸腺プロテアソーム欠損マウスCD8T細胞のレパトア解析,
第26回 Kyoto T Cell Conference, May 2016.
18. Kensuke Takada and Yousuke Takahama :
胸腺皮質における正の選択はCD8T細胞の抗原応答性を規定する,
第35回 日本胸腺研究会, Feb. 2016.
19. Naoko Matsui, Izumi Ohigashi, Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第35回日本胸腺研究会, Feb. 2016.
20. Mina Kozai, Izumi Ohigashi and Yousuke Takahama :
Defective self-tolerance in CCL21-deficient mice,
第44回日本免疫学会総会学術集会, Nov. 2015.
21. Izumi Ohigashi and Yousuke Takahama :
Differentiation potential of b5t+ thymic epithelial progenitors,
第44回日本免疫学会総会学術集会, Nov. 2015.
22. Kensuke Takada and Yousuke Takahama :
TCR sffinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8 T cells,
第44回日本免疫学会学術集会, Nov. 2015.
23. Naoko Matsui, Waka Sakai, Takahiro Furukawa, Takako Matsuoka, Masakazu Nakamura, Toshimasa Aranami, Kazuya Kondo, Tetsuya Kitagawa, Yousuke Takahama, Takashi Yamamura and Ryuji Kaji :
B cell analysis in human thymus,
第56日本神経学会学術大会, May 2015.
24. Kensuke Takada and Yousuke Takahama :
胸腺皮質上皮細胞を介した正の選択はT細胞の抗原応答性を規定する,
第25回 Kyoto T Cell Conference, May 2015.
25. Izumi Ohigashi and Yousuke Takahama :
成体の胸腺髄質上皮は髄質系列細胞によって維持・再生される,
第25回 Kyoto T Cell Conference, May 2015.
26. Bongju Kim, Izumi Ohigashi and Yousuke Takahama :
胸腺上皮細胞におけるミトコンドリアの役割,
第92回日本生理学会大会, Mar. 2015.
27. Yousuke Takahama :
生態防御のかなめ「Tリンパ球」を産生する「胸腺」の形成と機能,
第22回分子皮膚科フォーラム, Feb. 2015.
28. Bongju Kim, Izumi Ohigashi and Yousuke Takahama :
Role of mitochondria in thymic epithelial cells,
第43回日本免疫学会学術集会, Dec. 2014.
29. Bongju Kim, Izumi Ohigashi and Yousuke Takahama :
Role of mitochondria in thymic epithelial cells,
第43回日本免疫学会学術集会, Dec. 2014.
30. Izumi Ohigashi and Yousuke Takahama :
5t+ progenitors contribute to the maintenance and regeneration of medullary thymic epithelial cells,
第43回日本免疫学会学術集会, Dec. 2014.
31. Yousuke Takahama :
Thymus microenvironment for the formation of CD8 T cell repertoire,
第43回日本免疫学会学術集会, Dec. 2014.
32. Kensuke Takada and Yousuke Takahama :
Thymoproteasome-dependent positive selection conditions antigen responsiveness of CD8 T cells,
第43回日本免疫学会学術集会, Dec. 2014.
33. 香西 美奈, Izumi Ohigashi and Yousuke Takahama :
Defective T cell tolerance in CCL21 knockout mice,
第43回日本免疫学会学術集会, Dec. 2014.
34. Yousuke Takahama :
Thymus microenvironment for the formation of CD8 T cell repertoire,
第43回日本免疫学会学術集会, Dec. 2014.
35. Kensuke Takada and Yousuke Takahama :
正の選択を介して決定されるCD8T細胞の抗原応答性,
第157回日本獣医学会学術集会, Sep. 2014.
36. Yousuke Takahama :
感染防御のかなめ Tリンパ球を産生する胸腺の形成と機能,
第61回トキシンシンポジウム, Sep. 2014.
37. 香西 美奈, Izumi Ohigashi and Yousuke Takahama :
CCL21Ser欠損マウスにおける免疫異常,
第13回四国免疫フォーラム, Jun. 2014.
38. Izumi Ohigashi and Yousuke Takahama :
髄質上皮細胞の維持と再生におけるβ5t陽性前駆細胞の寄与,
第24回 Kyoto T Cell Conference, May 2014.
39. Kensuke Takada, Nhi Ngoc Le, 佐々木 克博, 村田 茂穂 and Yousuke Takahama :
胸腺プロテアソーム依存的に産生される自己ペプチドの正の選択における特性,
第24回 Kyoto T Cell Conference, May 2014.
40. Yousuke Takahama :
T cell repertoire formation in the thymus,
The 3rd NIF Winter School on Advanced Immunology, Jan. 2014.
41. Yousuke Takahama :
Tリンパ球レパトアを形成する胸腺微小環境,
大阪大学微生物研究所 Advanced Seminar Series on Microbiology and Immunology, Jan. 2014.
42. Izumi Ohigashi and Yousuke Takahama :
Development and developmental potential of5t-expressing thymic epithelial cells,
第42回日本免疫学会学術集会, Dec. 2013.
43. Kensuke Takada and Yousuke Takahama :
Functional conditioning of CD8 T cells by thymoproteasome-dependent positive selectio,
第42回日本免疫学会学術集会, Dec. 2013.
44. Yousuke Takahama :
Immune cells need stromal cells to work,
第42回日本免疫学会学術集会, Dec. 2013.
45. Yousuke Takahama :
死に行くT細胞へのレクイエム,
第36回日本分子生物学会, Dec. 2013.
46. Izumi Ohigashi and Yousuke Takahama :
胸腺皮質上皮細胞特異的β5tおよび髄質上皮細胞に発現するCCL21aの発現トレーサー実験による胸腺上皮細胞分化機構の解析,
第37回日本リンパ学会総会, Jun. 2013.
47. T Nakayama, Hirotsugu Kurobe, H Sugasawa, Hajime Kinoshita, M Higashida, Y Matsuoka, Y Yoshida, Y Hirata, M Sakata, Yousuke Takahama, Masataka Sata, Toshiaki Tamaki, Tetsuya Kitagawa and Shuhei Tomita :
Macrophage-specific HIF-1a-deficient Mice Suppress Vascular Remodeling.,
第77回 日本循環器学会学術集会, Mar. 2013.
48. Yousuke Takahama :
胸腺上皮細胞によるT細胞選択,
第9回宮崎サイエンスキャンプ, Feb. 2013.
49. 高井 ちか子, Yasushi Nakagawa, 大岩 由香里, 藤田 結衣, Hiromitsu Takizawa, Mitsuteru Yoshida, 川上 行奎, 梶浦 耕一郎, Shoji Sakiyama, Akira Tangoku, Yousuke Takahama and Kazuya Kondo :
ヒト胸腺・胸腺腫における皮質・髄質 component の distribution,
第32回日本胸腺研究会, Feb. 2013.
50. Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, Yousuke Takahama and Ryuji Kaji :
重症筋無力症の過形成胸腺ではハッサル小体が増加している,
第32回日本胸腺研究会, Feb. 2013.
51. Yousuke Takahama :
餅は餅屋,
第35回日本分子生物学会年会, Dec. 2012.
52. 矢野 弘太 and Yousuke Takahama :
Mouse IAN4/Gimap3 encodes a functional melecule that regulate cellularity of T cells,
第41回日本免疫学会学術集会, Dec. 2012.
53. Kensuke Takada and Yousuke Takahama :
Functional abnormality of peripheral CD8 T cells in beta 5t-deficient mice,
第41回日本免疫学会学術集会, Dec. 2012.
54. Naoko Matsui, Izumi Ohigashi and Yousuke Takahama :
Increased Hassalls corpuscles in myasthenia gravis patients carrying thymic hyperplasia,
41st Annual Meeting of The Japanese Society for Immunology, Dec. 2012.
55. Naoko Matsui, Izumi Ohigashi and Yousuke Takahama :
Increased Hassalls Corpuscles In Myasthenia Gravis Patients Carrying Thymic Hyperplasia,
第41回日本免疫学会学術集会, Dec. 2012.
56. Michiyuki Kasai, Ariunzaya BAT-ERDENE and Yousuke Takahama :
Cell-cell contact maintains beta 5t expression in cortical thymic epithelial cells,
第41回日本免疫学会学術集会, Dec. 2012.
57. Lkhagvasuren Enkhsaikhan and Yousuke Takahama :
Autoimmune regulator and lymphotoxin beta receptor affect the development of CCL21-producing medullary thymic epithelial cell,
第41回日本免疫学会学術集会, Dec. 2012.
58. Izumi Ohigashi and Yousuke Takahama :
Analysis of cortical and medullary bifurcation mechanisms in thymic epithelial cells using cortical thymic epithelial cell-specific beta 5t-Cre knock-in mice,
第41回日本免疫学会学術集会, Dec. 2012.
59. Yasushi Nakagawa and Yousuke Takahama :
Microarray analysis for CD classification of thymic epithelial cell subpopulations,
第41回日本免疫学会学術集会, Dec. 2012.
60. 中山 泰介, Shuhei Tomita, Hirotsugu Kurobe, 菅澤 典子, Hajime Kinoshita, Mikio Sugano, Tamotsu Kanbara, Eiki Fujimoto, Takashi Kitaichi, Toshiaki Tamaki, Masataka Sata, Yousuke Takahama and Tetsuya Kitagawa :
小口径グラフト開存性改善を目的とする血管リモデリングにおけるマクロファージの基礎研究,
第65回日本胸部外科学会定期学術集会, Oct. 2012.
61. Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, 野村 芳子, Yousuke Takahama and Ryuji Kaji :
重症筋無力症の過形成胸腺ではハッサル小体が増加している,
第24回日本神経免疫学会学術集会, Sep. 2012.
62. Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, 野村 芳子, Yousuke Takahama and Ryuji Kaji :
重症筋無力症の過形成胸腺ではハッサル小体が増加している,
第24回日本神経免疫学会, Sep. 2012.
63. Yousuke Takahama :
胸腺微小環境と自己免疫性涙腺異常,
第21回日本シェーグレン症候群学会学術集会, Sep. 2012.
64. Kensuke Takada and Yousuke Takahama :
β5t欠損マウスにおける末梢CD8T細胞の機能異常,
第21回 Kyoto T Cell Conference, Jul. 2012.
65. Izumi Ohigashi and Yousuke Takahama :
胸腺皮質上皮細胞特異的b5t遺伝子座にCreをノックインしたマウスの作製,
第22回 Kyoto T Cell Conference, Jul. 2012.
66. Lkhagvasuren Enkhsaikhan and Yousuke Takahama :
Molecular heterogeneity in medullary thymic epithelial cells,
第11回四国免疫フォーラム, Jun. 2012.
67. Taisuke Nakayama, Hirotsugu Kurobe, Noriko Sugasawa, Hajime Kinoshita, Mayuko Higashida, Yuuki Matsuoka, Mitsuru Takaku, Yasushi Yoshida, Yoichiro Hirata, Yousuke Takahama, Masataka Sata, Toshiaki Tamaki, Tetsuya Kitagawa and Shuhei Tomita :
Role of Hypoxia-Inducible Factor1-alpha in Macrophage as an Aggravation Regulator in Development of Vascular Remodeling.,
第76回 日本循環器学会学術集会, Mar. 2012.
68. Naoko Matsui, Izumi Ohigashi, 野村 芳子, Yousuke Takahama and Ryuji Kaji :
重症筋無力症患者胸腺における制御性T細胞ならびにハッサル小体の役割,
Clinical Neurology, Vol.51, No.12, 1300, Dec. 2011.
69. Michiyuki Kasai, Yousuke Takahama and Udono Heiichirho :
Expression profiles of beta5 subunits in thymic epithelial cell lines,
Proceedings of the Japanese Society for Immunology, Vol.40, 216, Nov. 2011.
70. Kensuke Takada and Yousuke Takahama :
Analysis of peripheral CD8 T cells in 5t-deficient mice,
第40回日本免疫学会学術集会, Nov. 2011.
71. Yasushi Nakagawa and Yousuke Takahama :
マウス胸腺上皮細胞のマイクロアレイ解析によるヒト胸腺解析法開発の試み,
第40回日本免疫学会学術集会, Nov. 2011.
72. Takeshi Nitta, Izumi Ohigashi, Yasushi Nakagawa and Yousuke Takahama :
Lympho-epithelial complexes in the thymic cortex,
第40回日本免疫学会学術集会, Nov. 2011.
73. Kouta YANO and Yousuke Takahama :
IAN4 and IAN5 critically regulates TCR-mediated survival of T cells,
第40回日本免疫学会学術集会, Nov. 2011.
74. Izumi Ohigashi and Yousuke Takahama :
Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice,
第40回日本免疫学会学術集会, Nov. 2011.
75. 笠井 道之, 鵜殿 平一郎 and Yousuke Takahama :
Expression profiles of beta5 subunits in thymic epithelial cell lines,
第40回日本免疫学会学術集会, Nov. 2011.
76. Kensuke Takada and Yousuke Takahama :
胸腺プロテアソーム非依存的に分化したCD8T細胞の機能解析,
第151回 日本獣医学会学術集会, Sep. 2011.
77. Yousuke Takahama :
中枢性免疫寛容と自己免疫疾患,
第35回阿蘇シンポジウム, Jul. 2011.
78. Kensuke Takada and Yousuke Takahama :
胸腺プロテアソーム構成因子β5t欠損マウスに認められるメモリー様CD8T細胞,
第21回 Kyoto T Cell Conference, Jun. 2011.
79. 新田 剛, 新田 幸子, Yasushi Nakagawa and Yousuke Takahama :
胸腺皮質上皮細胞と胸腺細胞の多細胞複合体,
第21回Kyoto T Cell Conference, Jun. 2011.
80. Yousuke Takahama :
ヒトプロテオゲノミクスネットワーク,
日本学術会議生命科学系シンポジウム「生命科学の将来に向けたマスタープラン」, May 2011.
81. 中山 知美, 佐々木 克博, Takeshi Nitta, Yousuke Takahama, 金子 岳海 and 村田 茂穂 :
胸腺特異的プロテアソームの発現制御機構の解析,
BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会), Dec. 2010.
82. Takeshi Nitta, Yasushi Nakagawa and Yousuke Takahama :
T細胞レパトア選択における胸腺皮質上皮細胞の役割,
BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会), Dec. 2010.
83. 矢野 弘太, Takeshi Nitta and Yousuke Takahama :
細胞内GTP結合タンパク質IAN4とIAN5はリンパ球の生存制御因子である,
BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会), Dec. 2010.
84. Hirotsugu Kurobe, Takashi Tominaga, Masahisa URATA, Mikio Sugano, Takashi Kitaichi, Tomohisa Kawahito, Takaki Hori, Yoshiyasu Egawa, Yousuke Takahama and Tetsuya Kitagawa :
The post-operative problem in the infants with total thymectomy, and its management.,
the 63rd Annual Scientific Meeting of the Japanese Association for Thoracic Surgery, Oct. 2010.
85. 矢野 弘太, Takeshi Nitta and Yousuke Takahama :
IAN4とIAN5はリンパ球の生存調節因子である,
第9回四国免疫フォーラム, Jun. 2010.
86. Kensuke Takada, Takeshi Nitta and Yousuke Takahama :
胸腺プロテアソーム構成因子β5t非依存的に分化したCD8T細胞の抗原特異性,
第20回Kyoto T Cell Conference, Jun. 2010.
87. Lei Yu, Ripen Mat Adiratna, Takeshi Nitta and Yousuke Takahama :
Aire regulates XCL1-mediated medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells,
第20回Kyoto T Cell Conference, Jun. 2010.
88. Takeshi Nitta, 新田 幸子, Yasushi Nakagawa and Yousuke Takahama :
T細胞レパトア選択における胸腺皮質上皮細胞の役割,
第20回 Kyoto T Cell Conference, Jun. 2010.
89. Hirotsugu Kurobe, 浦田 将久, 福原 弥生, 神原 保, Yousuke Takahama, 玉置 俊晃, Shuhei Tomita and Tetsuya Kitagawa :
血管リモデリング時の転写因子HIF-1αの役割,
第110 回日本外科学会定期学術集会, Apr. 2010.
90. Hirotsugu Kurobe, 浦田 将久, Yayoi Fukuhara, Tamotsu Kanbara, Ken-ichi Aihara, Masashi Akaike, Yousuke Takahama, Toshiaki Tamaki, Toshio Matsumoto, Shuhei Tomita and Tetsuya Kitagawa :
血管リモデリング時の転写因子HIF-1αの役割 (第110回日本外科学会定期学術集会),
Journal of Japan Surgical Society, Vol.111, No.2, 701, Mar. 2010.
(CiNii: 110007718434)
91. Takeshi Nitta and Yousuke Takahama :
胸腺クロストークによるT細胞レパトア形成の制御,
第32回日本分子生物学会年会, Dec. 2009.
92. Takeshi Nitta, 村田 茂穂, 藤猪 英樹, 小安 重夫, 田中 啓二 and Yousuke Takahama :
The thymoproteasome generates immunocompetent repertoire of CD8 T cells,
第39回 日本免疫学会総会・学術集会, Dec. 2009.
93. Naozumi Ishimaru, Rieko Arakaki, Akiko Yamada, Yousuke Takahama and Yoshio Hayashi :
In situ patrolling of regulatory T cells is essential for protecting organ-specific autoimmunity,
日本免疫学会総会・学術集会, Dec. 2009.
94. Takeshi Nitta, 村田 茂穂, 田中 啓二 and Yousuke Takahama :
胸腺プロテアソームはCD8 T細胞の「正の選択」を制御する,
第31回日本分子生物学会年会・第81回日本生化学会大会合同大会, Dec. 2008.
95. Takeshi Nitta, Shigeo Murata, Keiji Tanaka and Yousuke Takahama :
The thymoproteasome regulates positive selection of CD8 T cells,
第38回 日本免疫学会総会・学術集会, Dec. 2008.
96. Takeshi Nitta, 村田 茂穂, 田中 啓二 and Yousuke Takahama :
胸腺プロテアソーム構成因子b5tによる正の選択の制御,
第18回 Kyoto T Cell Conference, Jun. 2008.
97. Takeshi Nitta, 彦坂 雄, 松尾 光一 and Yousuke Takahama :
RANKLシグナルは正の選択による胸腺髄質形成を担う,
第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会, Dec. 2007.
98. Takeshi Nitta, 雷 宇 and Yousuke Takahama :
組織特異的自己抗原に対する負の選択は胸腺細胞のCCR7依存性髄質移動によって制御される,
第37回 日本免疫学会総会・学術集会, Nov. 2007.
99. Takeshi Nitta, 彦坂 雄 and Yousuke Takahama :
正の選択による胸腺髄質形成を担うTNFファミリー分子群,
第17回 Kyoto T Cell Conference, Jun. 2007.
100. Takeshi Nitta, 彦坂 雄 and Yousuke Takahama :
髄質形成を担う「胸腺クロストーク」シグナル,
第26回 日本胸腺研究会, Feb. 2007.
101. Takeshi Nitta, 宮崎 忠昭 and Yousuke Takahama :
IANファミリー分子によるTリンパ球のアポトーシス制御,
第36回 日本免疫学会総会・学術集会, Dec. 2006.
102. Takeshi Nitta, 郷司 敦史, 宮崎 忠昭 and Yousuke Takahama :
IAN family proteins regulate development and survival of T lymphocytes,
第36回 日本免疫学会総会・学術集会, Dec. 2006.
103. Takeshi Nitta and Yousuke Takahama :
IANファミリー分子によるTリンパ球の分化とアポトーシスの制御,
第5回 四国免疫フォーラム, Jun. 2006.
104. Takeshi Nitta, 劉 村蘭, 斉藤 ふみ and Yousuke Takahama :
胸腺細胞の髄質移動と自己寛容,
第16回 Kyoto T Cell Conference, Jun. 2006.
105. Hirotsugu Kurobe, T Tominaga, A Kurushima, Masashi Kano, Takashi Kitaichi, Yutaka Masuda, Yousuke Takahama and Tetsuya Kitagawa :
How will thymus extirpation in early infancy influence on achieving mature immune system?,
The 14th Annual Meeting of the Asian Society for Cardiovascular Surgery, Jun. 2006.
106. Takeshi Nitta, 宮崎 忠昭 and Yousuke Takahama :
IANファミリー分子によるTリンパ球のアポトーシス制御,
第35回 日本免疫学会総会・学術集会, Dec. 2005.
107. 澤上 一美, 近藤 勧, 杉浦 水香, 瀬川 修, 高橋 正明, 田島 秀二, 熊谷 俊高, 萩原 央子, 右田 清志, 八橋 弘, 石橋 大海, 中尾 一彦, 濱崎 圭輔, 江口 勝美, Yousuke Takahama, Mitsuo Itakura and 町田 雅之 :
蛍光アダプター法によるIL-18SNPサイトの自動タイピング,
第27回日本分子生物学会年会, 2005.
108. 近藤 勧, 澤上 一美, 瀬川 修, 池田 秀雄, 高橋 正明, 田島 秀二, 杉浦 水香, Yousuke Takahama, Mitsuo Itakura and 町田 雅之 :
蛍光バーコード磁気ビーズを用いた高感度SNPsタイピング技術の確立,
第27回日本分子生物学会年会, 2005.
109. Takeshi Nitta, 清家 隆史 and Yousuke Takahama :
IANファミリー遺伝子のクラスター構造は脊椎動物と高等植物に共有される,
第27回日本分子生物学会年会, Dec. 2004.
110. Hirotsugu Kurobe, Tomoo Ueno, 斉藤 ふみ, 劉 村蘭, Tetsuya Kitagawa and Yousuke Takahama :
Positively selected T lymphocytes can emigrate the thymus directly from the cortex,
第34回日本免疫学会総会, Dec. 2004.
111. 澤上 一美, 阿部 初美, 瀬川 修, 高橋 正明, 田島 秀二, 近藤 勧, 中村 道大, 杉浦 水香, 萩原 央子, Maki Moritani, 国香 清, Yousuke Takahama, Mitsuo Itakura and 町田 雅之 :
高精度・自動化SNPsタイピング技術の実用化研究開発,
第27回日本分子生物学会年会, 2004.
112. Hirokazu Miyoshi, Hiromu Nishitani, Akio Adachi, 佐藤 晃一, Tokue Kuroda, 長谷川 豊司, Akemi Matsushima and Yousuke Takahama :
放射能デモンストレーションキットを用いた教育訓練の実施,
日本放射線安全管理学会 第1回学術大会, Dec. 2002.

Et cetera, Workshop:

1. Sayumi Fujimori, Izumi Ohigashi, 高田 慎治 and Yousuke Takahama :
胸腺上皮細胞特異的なWnt/β-cateninシグナル経路活性制御の影響,
第18回 四国免疫フォーラム, Jun. 2019.
2. 村松 直美, Izumi Ohigashi and Yousuke Takahama :
CD8T細胞の正の選択におけるペプチドスイッチ仮説の検証,
第29回 Kyoto T cell conference, Jun. 2019.
3. Izumi Ohigashi and Yousuke Takahama :
胸腺上皮細胞のオミクスプロファイリング,
第29回 Kyoto T cell conference, Jun. 2019.
4. Khanom Shahina Umme, Kenta Kondou, Kensuke Takada, Izumi Ohigashi and Yousuke Takahama :
Peptide-induced positive selection of CD8+ T cells in vivo,
第17回 四国免疫フォーラム, Jun. 2018.
5. 近藤 博之, Yousuke Takahama and Izumi Ohigashi :
胸腺皮質上皮細胞で高発現する新規分子の機能解析,
第28回 Kyoto T cell Conference, Jun. 2018.
6. Naoko Matsui, Izumi Ohigashi, 山本 遥平, 中川 英刀, Kazuya Kondo and Yousuke Takahama :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第37回日本胸腺研究会, Feb. 2018.
7. Izumi Ohigashi and Yousuke Takahama :
T細胞の自己寛容性確立におけるCCL21の役割,
第37回 日本胸腺研究会, Feb. 2018.
8. 藤原 翔, 森 空悟, Izumi Ohigashi, Yousuke Takahama and 早坂 晴子 :
メラノーマ組織に形成される高内皮細静脈様血管の検出,
第26回がん転移学会学術集会・総会, Jul. 2017.
9. 近藤 博之, Izumi Ohigashi and Yousuke Takahama :
CCL21Ser欠損マウスにおけるT細胞異常,
第16回四国免疫フォーラム, Jun. 2017.
10. Izumi Ohigashi and Yousuke Takahama :
胸腺髄質上皮細胞の再生におけるβ5t陽性上皮前駆細胞の寄与,
第36回胸腺研究会, Feb. 2017.
11. Naoko Matsui, Izumi Ohigashi, 中川 英刀, Kazuya Kondo and Yousuke Takahama :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第36回日本胸腺研究会, Feb. 2017.
12. 香西 美奈, Izumi Ohigashi and Yousuke Takahama :
CCL21,
第15回四国免疫フォーラム, Jun. 2016.
13. Izumi Ohigashi and Yousuke Takahama :
髄質上皮細胞の維持と再生におけるb5t陽性前駆細胞の寄与,
第35回胸腺研究会, Feb. 2016.
14. Naoko Matsui, Izumi Ohigashi, Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第35回日本胸腺研究会, 39, Feb. 2016.
15. 近藤 博之, Izumi Ohigashi and Yousuke Takahama :
胸腺皮質上皮細胞で高発現される機能未知新規遺伝子の研究,
2015感染免疫クラスター・ミニリトリート, Nov. 2015.
16. Myn Uddin, Izumi Ohigashi and Yousuke Takahama :
Seeking transcriptional mechanisms for regulation of b5t expression,
第14回 四国免疫フォーラム, Jun. 2015.
17. Naoko Matsui, Izumi Ohigashi, Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama :
ヒト胸腺を用いた単一細胞解析への試み,
第34回日本胸腺研究会, Feb. 2015.
18. Uddin Md.Myn, Izumi Ohigashi and Yousuke Takahama :
Seeking transcriptional mechanisms for regulation of 5t expression,
2014感染免疫クラスター・ミニリトリート, Oct. 2014.
19. 近藤 博之, Izumi Ohigashi and Yousuke Takahama :
胸腺皮質上皮細胞で高発現される機能未知新規遺伝子の研究:ノックアウトマウスと特異的抗体の作製によるアプローチ,
2014感染免疫クラスター・ミニリトリート, Oct. 2014.
20. Naoko Matsui, Yasushi Nakagawa, Kazuya Kondo, Ryuji Kaji and Yousuke Takahama :
重症筋無力症の過形成胸腺ではハッサル小体が増加している,
第33回日本胸腺研究会, Feb. 2014.
21. 松井 尚子, Yasushi Nakagawa, Kazuya Kondo, Ryuji Kaji and Yousuke Takahama :
第33回日本胸腺研究会,
重症筋無力症の過形成胸腺ではハッサル小体が増加している, Feb. 2014.
22. Ryuji Kaji, Naoko Matsui, 古川 貴大, Kazuya Kondo, Yousuke Takahama and 野村 芳子 :
重症筋無力症の発症機序:過形成胸腺ではハッサル小体が増加している,
免疫性神経疾患に関する調査研究班(平成25年度), Jan. 2014.
23. Togoo Khongorzul, Yousuke Takahama and Kensuke Takada :
Characterization of SMA-expressing stromal cells in lymph nodes,
2013感染免疫クラスター・ミニリトリート, Nov. 2013.
24. 香西 美奈, Izumi Ohigashi and Yousuke Takahama :
CCL21Ser欠損マウスにおける免疫システムの解析,
2013感染免疫クラスター・ミニリトリート, Oct. 2013.
25. Togoo Khongorzul, Yousuke Takahama and Kensuke Takada :
How do the lymph nodes maintain memory CD8 T cells?,
第12回四国免疫フォーラム, Jun. 2013.
26. 高井 ちか子, Yasushi Nakagawa, 大岩 由香理, 藤田 結衣, Hiromitsu Takizawa, Mitsuteru Yoshida, Yukikiyo Kawakami, Koichiro Kajiura, Shoji Sakiyama, Akira Tangoku, Yousuke Takahama and Kazuya Kondo :
ヒト胸腺・胸腺腫における皮質・髄質componentのdistribution,
第32回日本胸腺研究会, Feb. 2013.
27. Enkhsaikhan Lkhagvasuren and Yousuke Takahama :
Molecular heterogeneity in medullary thymic epithelial cells,
第11回四国免疫フォーラム, Jun. 2012.
28. Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama :
マウス胸腺上皮細胞のマイクロアレイ解析によるヒト胸腺上皮性腫瘍解析法開発,
第31回日本胸腺研究会, Feb. 2012.
29. Yousuke Takahama :
胸腺の機能,
2011 Tokushima Bioscience Retreat, Sep. 2011.
30. Yasushi Nakagawa, 大岩 由香理 and Yousuke Takahama :
マウス胸腺上皮細胞のマイクロアレイ解析によるヒト胸腺解析法開発の試み,
第10回四国免疫フォーラム, Jun. 2011.
31. Takeshi Nitta, Yasushi Nakagawa and Yousuke Takahama :
「胸腺ナース細胞」型多細胞複合体のT細胞レパトア選択における役割,
第30回日本胸腺研究会, Feb. 2011.
32. Yasushi Nakagawa, 大岩 由香理, Takeshi Nitta and Yousuke Takahama :
マウス胸腺上皮細胞のマイクロアレイ解析によるヒト胸腺解析法開発の試み,
第30回日本胸腺研究会, Feb. 2011.
33. Yousuke Takahama :
胸腺におけるT細胞選択と自己免疫疾患,
第5回小児重症筋無力症研究会, May 2010.
34. Yousuke Takahama :
胸腺の構築,
第1回Synthetic Immunology研究会, Apr. 2010.
35. Takeshi Nitta, 新田 幸子, Yasushi Nakagawa and Yousuke Takahama :
胸腺皮質上皮細胞の一部は「胸腺ナース細胞」である,
第29回日本胸腺研究会, Feb. 2010.
36. Hirotsugu Kurobe, Shuhei Tomita, Yasunobu Hayabuchi, Kazuhiro Mori, Tetsuya Kitagawa and Yousuke Takahama :
新生児から乳児期における胸腺の全摘出あるいは部分切除が免疫系発生に与える影響,
第25回日本胸腺研究会, Feb. 2006.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 免疫四次元空間ダイナミクス (Project/Area Number: 17H06080 )
  • 胸腺における「正の選択」の本質を問う (Project/Area Number: 16H02630 )
  • Positive selection dictates T cell-mediated body defense (Project/Area Number: 26460576 )
  • Development and function of thymic microenvironments (Project/Area Number: 24111004 )
  • Analysis and Synthesis of Multidimensional Immune Organ Network (Project/Area Number: 24111001 )
  • The challenge for the development of therapy for autoimmune disorder by the establishment of artificial thymic medullary organ (Project/Area Number: 23659241 )
  • Molecular basis for the thymic microenvironments that characterize the immune system (Project/Area Number: 23249025 )
  • Roles of lymph node stromal cell network in T cell homeostasis (Project/Area Number: 22790467 )
  • 胸腺プロテアソームの機能 (Project/Area Number: 21025023 )
  • Tリンパ球再選択による自己免疫疾患治療法開発への挑戦 (Project/Area Number: 21659122 )
  • Molecular mechanisms that regulate the formation of the thymic microenvironments (Project/Area Number: 20390144 )
  • Thymic microenvironments for shaping T cell repertoire (Project/Area Number: 19059010 )
  • Immunological Self Recognition and its Disorders (Project/Area Number: 19059009 )
  • 胸腺の器官形成を担う分子ネットワークのマスターマップ作成 (Project/Area Number: 18659140 )
  • 生体防御と免疫病制御の統合的パラダイム (Project/Area Number: 18639002 )
  • Cellular dyntarnics and migration during T-Iympharyle development and selection in the thymus (Project/Area Number: 18390153 )
  • 胸腺器官発生機構の包括的解析 (Project/Area Number: 18016023 )
  • The roles of HIF-1α in T cell-dependent immune responses (Project/Area Number: 17590436 )
  • Thymocyte dynamics and hymus organogenesis (Project/Area Number: 16043237 )
  • Molecular mechanisms of cell migration during T-lymphocyte development (Project/Area Number: 15390161 )
  • Dynamism of immune cells in immune-tissue formation (Project/Area Number: 15078203 )
  • エチルニトロソウレアによるメダカ変異体の収集に基づく胸腺器官形成機構の解析 (Project/Area Number: 15011240 )
  • Tリンパ球の分化選択制御に基づくがん治療法の開発 (Project/Area Number: 14030060 )
  • 幼若Tリンパ球の「無の選択」から探る新しい細胞内遺伝子産物感知機構 (Project/Area Number: 13877049 )
  • Study on the role of histamine H1 receptors in the central nervous system using gene-targeted mouse (Project/Area Number: 13672289 )
  • 幼若Tリンパ球への遺伝子導入に基づいたがん免疫療法の開発 (Project/Area Number: 13218092 )
  • Molecular signals that regulate the development and movements of developing T lymphocytes (Project/Area Number: 12470077 )
  • がんの免疫療法のための幼若Tリンパ球への遺伝子導入 (Project/Area Number: 12217102 )
  • リンパ球の系列分岐・運命分岐を決定するシグナル伝達機構 (Project/Area Number: 12051219 )
  • Mechanisms for differentiation and selection of T, NKT and NK cells (Project/Area Number: 11694241 )
  • T・Bリンパ球の分化方向決定に遺伝的異常を示すマウス (Project/Area Number: 11162205 )
  • 遺伝子導入によるTリンパ球分化促進に基づくエイズ治療法の開発 (Project/Area Number: 11161201 )
  • がんの免疫療法のための幼若Tリンパ球への遺伝子導入 (Project/Area Number: 11140212 )
  • レパートリー形成の分子機構 (Project/Area Number: 08282103 )
  • Expression and function of pT-alpha, a component of pre-TCR (Project/Area Number: 10670297 )
  • がんの免疫療法に向けての遺伝子導入によるTリンパ球の分化誘導 (Project/Area Number: 09255210 )
  • T細胞の胸腺内分化を制御する新しい表面分子のクローニング (Project/Area Number: 08877059 )
  • Characterization of the hematopoietic stem cell and search for the molecules responsible for stem cell self-renewal. (Project/Area Number: 08407028 )
  • T細胞の胸腺内選択の分子機構 (Project/Area Number: 08282202 )
  • Molecular mechanism of T cell differentiation (Project/Area Number: 08044242 )
  • Carachterization of B cell stimulatory factor capable of inducing autoantibody production and its receptor (Project/Area Number: 62570215 )
  • Search by Researcher Number (20183858)