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Research Activity

Field of Study

periodontal disease

Subject of Study

歯周炎病変局所へのリンパ球浸潤機構に関する研究 (periodontal disease)

Book / Paper

Academic Paper (Judged Full Paper):

1.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-α-Stimulated Human Periodontal Ligament Cells.,
Inflammation, Vol.42, No.4, 1456-1462, 2019.
(DOI: 10.1007/s10753-019-01007-z,   PubMed: 30997585)
2.Ikuko Hosokawa, Yoshitaka Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Carnosic Acid Inhibits CXCR3 Ligands Production in IL-27-Stimulated Human Oral Epithelial Cells.,
Inflammation, Vol.42, No.4, 1311-1316, 2019.
(DOI: 10.1007/s10753-019-00991-6,   PubMed: 30820808)
3.Satoru Shindo, Yoshitaka Hosokawa, Ikuko Hosokawa and Hideki Shiba :
Interleukin (IL)-35 Suppresses IL-6 and IL-8 Production in IL-17A-Stimulated Human Periodontal Ligament Cells.,
Inflammation, Vol.42, No.3, 835-840, 2019.
(DOI: 10.1007/s10753-018-0938-9,   PubMed: 30484005)
4.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells.,
Inflammation, Vol.41, No.6, 2110-2115, 2018.
(DOI: 10.1007/s10753-018-0854-z,   PubMed: 30039429)
5.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Transforming growth factor-β1 increases C-C chemokine ligand 11 production in interleukin 4-stimulated human periodontal ligament cells.,
Cell Biology International, Vol.42, No.10, 1395-1400, 2018.
(Tokushima University Institutional Repository: 112813,   DOI: 10.1002/cbin.11030,   PubMed: 29993161)
6.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
IL-27 Modulates Chemokine Production in TNF- -Stimulated Human Oral Epithelial Cells.,
Cellular Physiology and Biochemistry, Vol.43, No.3, 1198-1206, 2017.
(Tokushima University Institutional Repository: 112954,   DOI: 10.1159/000481760,   PubMed: 28977795)
7.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
IL-29 Enhances CXCL10 Production in TNF--stimulated Human Oral Epithelial Cells.,
Immunological Investigations, Vol.46, No.6, 615-624, 2017.
(Tokushima University Institutional Repository: 112817,   DOI: 10.1080/08820139.2017.1336176,   PubMed: 28753407)
8.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells.,
Inflammation, Vol.40, No.2, 360-365, 2017.
(Tokushima University Institutional Repository: 112816,   DOI: 10.1007/s10753-016-0482-4,   PubMed: 27896541)
9.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Yoshihiro Ohta, Kazumi Ozaki and Takashi Matsuo :
Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells.,
Cell Biology International, Vol.40, No.12, 1380-1385, 2016.
(Tokushima University Institutional Repository: 112812,   DOI: 10.1002/cbin.10692,   PubMed: 27743458)
10.Ikuko Hosokawa, Yoshitaka Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
Melatonin Inhibits CXCL10 and MMP-1 Production in IL-1-Stimulated Human Periodontal Ligament Cells.,
Inflammation, Vol.39, No.4, 1520-1526, 2016.
(Tokushima University Institutional Repository: 112815,   DOI: 10.1007/s10753-016-0386-3,   PubMed: 27271323)
11.Satoru Shindo, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells.,
Inflammation, Vol.39, No.3, 1124-1129, 2016.
(Tokushima University Institutional Repository: 112814,   DOI: 10.1007/s10753-016-0344-0,   PubMed: 27072015)
12.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
IL-4 Modulates CCL11 and CCL20 Productions from IL-1-Stimulated Human Periodontal Ligament Cells.,
Cellular Physiology and Biochemistry, Vol.38, No.1, 153-159, 2016.
(Tokushima University Institutional Repository: 112953,   DOI: 10.1159/000438617,   PubMed: 26765337)
13.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
Calcitriol Suppressed Inflammatory Reactions in IL-1-Stimulated Human Periodontal Ligament Cells.,
Inflammation, Vol.38, No.6, 2252-2258, 2015.
(DOI: 10.1007/s10753-015-0209-y,   PubMed: 26156812,   Elsevier: Scopus)
14.Tadashi Nakanishi, Kayo Mukai, Yoshitaka Hosokawa, Daisuke Takegawa and Takashi Matsuo :
Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells,
International Endodontic Journal, Vol.48, No.3, 277-282, 2015.
(DOI: 10.1111/iej.12312,   PubMed: 24847951)
15.Satoru Shindo, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Genipin inhibits MMP-1 and MMP-3 release from TNF--stimulated human periodontal ligament cells.,
Biochimie, Vol.107PB, 391-395, 2014.
(DOI: 10.1016/j.biochi.2014.10.008,   PubMed: 25457105,   Elsevier: Scopus)
16.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
IL-22 Enhances CCL20 Production in IL-1-Stimulated Human Gingival Fibroblasts.,
Inflammation, Vol.37, No.6, 2062-2066, 2014.
(DOI: 10.1007/s10753-014-9939-5,   PubMed: 24902798,   Elsevier: Scopus)
17.Yoshitaka Hosokawa, Satoru Shindo, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
IL-6 trans-signaling enhances CCL20 production from IL-1-stimulated human periodontal ligament cells.,
Inflammation, Vol.37, No.2, 381-386, 2014.
(DOI: 10.1007/s10753-013-9750-8,   PubMed: 24081898,   Elsevier: Scopus)
18.Satoru Shindo, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Genipin inhibits IL-1-induced CCL20 and IL-6 production from human periodontal ligament cells.,
Cellular Physiology and Biochemistry, Vol.33, No.2, 357-364, 2014.
(DOI: 10.1159/000356675,   PubMed: 24557363,   Elsevier: Scopus)
19.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
(-)-Epigallocatechin-3-Gallate Inhibits CC Chemokine Ligand 11 Production in Human Gingival Fibroblasts.,
Cellular Physiology and Biochemistry, Vol.31, No.6, 960-967, 2013.
(DOI: 10.1159/000350114,   PubMed: 23839108)
20.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
TLR3 agonist enhances CC chemokine ligand 20 production in IL-1-stimulated human gingival fibroblasts.,
Cellular Immunology, Vol.283, No.1-2, 8-11, 2013.
(DOI: 10.1016/j.cellimm.2013.05.005,   PubMed: 23850670)
21.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
Tumor necrosis factor-like weak inducer of apoptosis increases CC chemokine ligand 20 production in interleukin 1-stimulated human gingival fibroblasts.,
Human Immunology, Vol.73, No.5, 470-473, 2012.
(DOI: 10.1016/j.humimm.2012.02.021,   PubMed: 22425737)
22.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
Interleukin (IL)-17A synergistically enhances CC chemokine ligand 20 production in IL-1-stimulated human gingival fibroblasts.,
Human Immunology, Vol.73, No.1, 26-30, 2012.
(DOI: 10.1016/j.humimm.2011.10.004,   PubMed: 22019504)
23.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo :
Black tea polyphenol inhibits CXCL10 production in oncostatin M-stimulated human gingival fibroblasts.,
International Immunopharmacology, Vol.11, No.6, 670-674, 2011.
(DOI: 10.1016/j.intimp.2011.01.009,   PubMed: 21255696)
24.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
Oncostatin M synergistically induces CXCL10 and ICAM-1 expression in IL-1beta-stimulated-human gingival fibroblasts.,
Journal of Cellular Biochemistry, Vol.111, No.1, 40-48, 2010.
(DOI: 10.1002/jcb.22648,   PubMed: 20680966)
25.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo :
Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts.,
Molecular Nutrition & Food Research, Vol.54 Suppl 2, S151-8, 2010.
(DOI: 10.1002/mnfr.200900549,   PubMed: 20461739)
26.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo :
Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts,
The Journal of Nutritional Biochemistry, Vol.21, No.7, 659-664, 2010.
(DOI: 10.1016/j.jnutbio.2009.04.005,   PubMed: 19616927)
27.Tadashi Nakanishi, Kayo Mukai, Hiromichi Yumoto, Kouji Hirao, Yoshitaka Hosokawa and Takashi Matsuo :
Anti-inflammatory effect of catechin on cultured dental pulp cells affected by bacteria-derived factors,
European Journal of Oral Sciences, Vol.118, No.2, 145-150, 2010.
(DOI: 10.1111/j.1600-0722.2010.00714.x,   PubMed: 20487003)
28.Ikuko Hosokawa, Yoshitaka Hosokawa, Kazumi Ozaki, Hiromichi Yumoto, Hideaki Nakae and Takashi Matsuo :
Proinflammatroy effects of muramyldipeptide on human gingival fibroblasts,
Journal of Periodontal Research, Vol.45, No.2, 193-199, 2010.
(DOI: 10.1111/j.1600-0765.2009.01217.x,   PubMed: 20470259)
29.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
TNFSF14 coordinately enhances CXCL10 and CXCL11 production from IFN-gamma-stimulated human gingival fibroblasts,
Molecular Immunology, Vol.47, No.4, 666-670, 2010.
(DOI: 10.1016/j.molimm.2009.10.018,   PubMed: 19939453)
30.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo :
Catechins Inhibit CCL20 Production in IL-17A-stimulated Human Gingival Fibroblasts,
Cellular Physiology and Biochemistry, Vol.24, No.5-6, 391-396, 2009.
(DOI: 10.1159/000257431,   PubMed: 19910679)
31.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
Human gingival fibroblasts express functional chemokine receptor CXCR6.,
Clinical and Experimental Immunology, Vol.156, No.3, 413-418, 2009.
(DOI: 10.1111/j.1365-2249.2009.03915.x,   PubMed: 19438592)
32.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
Cytokines differentially regulate CXCL10 production by interferon-gamma-stimulated or tumor necrosis factor-alpha-stimulated human gingival fibroblasts.,
Journal of Periodontal Research, Vol.44, No.2, 225-231, 2009.
(DOI: 10.1111/j.1600-0765.2008.01124.x,   PubMed: 18973545)
33.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
CC Chemokine ligand 17 in periodontal diseases: expression in diseased tissues and production by human gingival fibroblasts,
Journal of Periodontal Research, Vol.43, No.4, 471-477, 2008.
(DOI: 10.1111/j.1600-0765.2007.01080.x,   PubMed: 18557811)
34.Ikuko Hosokawa, Yoshitaka Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
Adrenomedullin suppresses tumour necrosis factor alpha-induced CXC chemokine ligand 10 production by human gingival fibroblasts.,
Clinical and Experimental Immunology, Vol.152, No.3, 568-575, 2008.
(DOI: 10.1111/j.1365-2249.2008.03647.x,   PubMed: 18435806)
35.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
CXC chemokine ligand 16 in periodontal diseases: expression in diseased tissues and production by cytokine-stimulated human gingival fibroblasts.,
Clinical and Experimental Immunology, Vol.149, No.1, 146-154, 2007.
(DOI: 10.1111/j.1365-2249.2007.03398.x,   PubMed: 17459077)
36.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts.,
Clinical and Experimental Immunology, Vol.146, No.3, 540-549, 2006.
(DOI: 10.1111/j.1365-2249.2006.03233.x,   PubMed: 17100776)
37.Ikuko Hosokawa, Yoshitaka Hosokawa, H Komatsuzawa, RB Goncalves, N Karimbux, MH Napimoga, Makoto Seki, K Ouhara, M Sugai, Martin A Taubman and Toshihisa Kawai :
Innate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue.,
Clinical and Experimental Immunology, Vol.146, No.2, 218-225, 2006.
(DOI: 10.1111/j.1365-2249.2006.03200.x,   PubMed: 17034573)
38.Toshihisa Kawai, Takashi Matsuyama, Yoshitaka Hosokawa, Seichou Makihira, Makoto Seki, Karimbux Nadeem, Goncalves B. Reginaldo, Valverde Paloma, Dibart Serge, Li Yi-Ping, Miranda A. Leticia, Ernst W.O. Cory, Izumi Yuichi and Martin A Taubman :
B and T Lymphocytes Are the Primary Sources of RANKL in the Bone Resorptive Lesion of Periodontal Disease,
The American Journal of Pathology, Vol.169, No.3, 987-998, 2006.
(DOI: 10.2353/ajpath.2006.060180,   PubMed: 16936272)
39.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
Cytokines differentially regulate ICAM-1 and VCAM-1 expression on human gingival fibroblasts.,
Clinical and Experimental Immunology, Vol.144, No.3, 494-502, 2006.
(DOI: 10.1111/j.1365-2249.2006.03064.x,   PubMed: 16734619)
40.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
Increase of CCL20 expression by human gingival fibroblasts upon stimulation with cytokines and bacterial endotoxin,
Clinical and Experimental Immunology, Vol.142, No.2, 285-291, 2005.
(DOI: 10.1111/j.1365-2249.2005.02912.x,   PubMed: 16232215)
41.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae, Keiji Murakami, Yoichiro Miyake and Takashi Matsuo :
CXCL12 and CXCR4 expression by human gingival fibroblasts in periodontal disease,
Clinical and Experimental Immunology, Vol.141, No.3, 467-474, 2005.
(DOI: 10.1111/j.1365-2249.2005.02852.x,   PubMed: 16045736)
42.Yoshitaka Hosokawa, Tadashi Nakanishi, Daisuke Yamaguchi, Hideaki Nakae and Takashi Matsuo :
Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in periodontal diseased tissue,
Clinical and Experimental Immunology, Vol.139, No.3, 506-512, 2005.
(DOI: 10.1111/j.1365-2249.2005.02675.x,   PubMed: 15730397)
43.Tadashi Nakanishi, Kanako Takahashi, Yoshitaka Hosokawa, Tomohiko Adachi, Hideaki Nakae and Takashi Matsuo :
Expression of macrophage inflammatory protein 3alpha in human inflamed dental pulp tissue,
Journal of Endodontics, Vol.31, No.2, 84-87, 2005.
(DOI: 10.1097/01.don.0000143414.22112.57,   PubMed: 15671814)
44.Yoshitaka Hosokawa, Tadashi Nakanishi, Daisuke Yamaguchi, Kanako Takahashi, Hiromichi Yumoto, Kazumi Ozaki and Takashi Matsuo :
Macrophage Inflammatory Protein 3α-CC chemokine receptor 6 interactions play an important role in CD4+ T-cell accumulation in periodontal diseased tissue.,
Clinical and Experimental Immunology, Vol.128, No.3, 548-554, 2002.
(DOI: 10.1046/j.1365-2249.2002.01865.x,   PubMed: 12067311)
45.Tadashi Nakanishi, Hirotoshi Shimizu, Yoshitaka Hosokawa and Takashi Matsuo :
An immunohistological study on cyclooxygenase-2 in human dental pulp.,
Journal of Endodontics, Vol.27, No.6, 385-388, 2001.
(DOI: 10.1097/00004770-200106000-00003,   PubMed: 11487130)

Review, Commentary:

1.Yoshitaka Hosokawa :
Mechanisms of Lymphocytes Infiltration in Periodontal Lesion,
Journal of the Japanese Association of Periodontology, Vol.57, No.2, 61-69, Jul. 2015.
2.Yoshitaka Hosokawa :
The Study of Chemokines in Periodontal Diseases and Regulation of its Expression,
Shikoku Dental Research, Vol.20, No.2, 235-240, Jan. 2008.
(Tokushima University Institutional Repository: 109768)
3.Toshihisa Kawai, Seichou Makihira, Yoshitaka Hosokawa, Makoto Seki and Martin A Taubman :
歯周病における活性化T細胞およびB細胞の組織破壊への関与,
Inflammation & Immunology, Vol.12, No.4, 425-433, Jul. 2004.
4.Yoshitaka Hosokawa, Tadashi Nakanishi and Takashi Matsuo :
Expresion of Chemokines in periodontitis,
Clinical Immunology, Vol.38, No.2, 151-156, Feb. 2002.
5.Tadashi Nakanishi, Kanako Takahashi, Yoshitaka Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Bacterial irritation and pulpal response in pulpitis,
Shikoku Dental Research, Vol.14, No.2, 255-263, 2002.

Proceeding of International Conference:

1.Shindo Satoru, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
The effect of genipin on dendritic cells activation,
93rd General Session & Exhibition of the IADR, Boston, Mar. 2015.
2.Ikuko Hosokawa, Yoshitaka Hosokawa, Shindo Satoru, Kazumi Ozaki and Takashi Matsuo :
Melatonin inhibits inflammatory mediators productions in human periodontal ligament cells,
93rd General Session & Exhibition of the IADR, Mar. 2015.
3.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
IL-4 modulates chemokine productions from IL-1-stimulated human periodontal ligament cells,
93rd General Session & Exhibition of the IADR, Boston, Mar. 2015.
4.Satoru Shindo, Yoshitaka Hosokawa, Ikuko Hosokawa and Takashi Matsuo :
The effect of genipin on MMP-1 and MMP-3 expression in IL-1beta-stimulated human periodontal ligament cells,
The 15th Joint Scientific Meeting of JSCD-KACD, Gyeongju, Korea, Nov. 2013.
5.Ikuko Hosokawa, Yoshitaka Hosokawa, Kazumi Ozaki, Hiromichi Yumoto, Hideaki Nakae and Takashi Matsuo :
Pro-inflammatory Roles of NOD2 in Human Gingival Fibroblasts,
The 3rd International Symposium on "Oral Sciences to Improve the Quality of Life", Sep. 2008.
6.Ikuko Hosokawa, Yoshitaka Hosokawa, Kazumi Ozaki, Hiromichi Yumoto, Hideaki Nakae and Takashi Matsuo :
Pro-inflammatory Roles of NOD2 in Human Gingival Fibroblasts,
86th General Session and Exhibition of the International Association for Dental Research, Jul. 2008.
7.Kayo Mukai, Tadashi Nakanishi, Yoshitaka Hosokawa, Kanako Takahashi and Takashi Matsuo :
Inhibitory effects of catechins on inflammatory reactions in pulp fibroblasts,
84th General Session & Exhibition of the IADR, Brisbane, Jun. 2006.
8.Yoshitaka Hosokawa, Tadashi Nakanishi, Daisuke Yamaguchi, Hiromichi Yumoto and Takashi Matsuo :
LARC-CCR6 Interactions play an important role in CD4+ T cell accumulation in periodontal diseased tissue,
80th General Session and Exhibition of the International Association for Dental Research, San Diego(USA), Mar. 2002.
9.Tadashi Nakanishi, Kanako Takahashi, Yoshitaka Hosokawa, Daisuke Yamaguchi, Chihiro Shinohara, Hiromichi Yumoto and Takashi Matsuo :
Expression of macrophage inflammatory protein-3 α in human pulpitis,
80th General SEssion ofthe IADR(International Association of Dental Research), San Diego(USA), Mar. 2002.
10.Hiromichi Yumoto, Daisuke Yamaguchi, Yoshitaka Hosokawa, Chihiro Shinohara, Tadashi Nakanishi, Hirotoshi Shimizu, Masayoshi Yamada, Hideaki Nakae and Takashi Matsuo :
Expression of IL-18 and IL-18 receptor in human periodontally diseased tissue,
Modern Periodontology New Directions in 21st Century-, Kanagawa(Japan), Jun. 2001.

Proceeding of Domestic Conference:

1.Ikuko Hosokawa, Yoshitaka Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Carnosic acidはヒト口腔上皮細胞のIL-27誘導CXCR3リガンド産生を抑制する,
日本歯科保存学会2018年度秋季学術大会, Nov. 2018.
2.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
IL-27 induces CXCR3 ligands production in human oral epithelial cells,
第61回日本歯周病学会春季学術大会, Jun. 2018.
3.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
IL-29 enhances CXCL10 production in TNF-alpha-stimulated human oral epithelial cells,
第60回日本歯周病学会秋季学術大会, Dec. 2017.
4.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
IL-29 enahances CXCL10 production in human oral epithelial cells,
第60回日本歯周病学会春季学術大会, Oct. 2017.
5.Shindo Satoru, Ikeda Atsushi, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Citrullinated vimentin promotes osteoclastgenesis,
日本歯科保存学会2016年度秋季学術大会, Oct. 2016.
6.Yoshitaka Hosokawa, Ikuko Hosokawa, Shindo Satoru, Kazumi Ozaki and Takashi Matsuo :
The effect of Gominsin N on inflammatory cytokine production in human periodontal ligament cells,
日本歯科保存学会2016年度秋季学術大会, Oct. 2016.
7.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
The effect of alkannin on IL-6 and CCL20 production in human periodontal ligament cells,
第59回春季日本歯周病学会学術大会, May 2016.
8.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
The effects of alkannin on CCR5 ligands production from human periodontal ligament cells,
日本歯科保存学会2015年度秋季学術大会, Nov. 2015.
9.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
Effects of IL-4 on CCL11 and CCL20 productions in human periodontal ligament cells,
第58回秋季日本歯周病学会学術大会, Sep. 2015.
10.Yoshitaka Hosokawa :
歯周炎病変局所へのリンパ球浸潤機構の解析,
第58回春季日本歯周病学会学術大会, May 2015.
11.Shindo Satoru, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Shikoninがヒト歯根膜由来細胞のIL-6およびIL-8産生に与える影響,
第141回日本歯科保存学会秋季学術大会, Oct. 2014.
12.Shindo Satoru, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
GenipinはE.coli LPSが誘導するヒト歯根膜細胞のIL-6およびIL-8産生を抑制する,
第140回日本歯科保存学会春季学術大会, Jun. 2014.
13.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
活性型ビタミンDはIL-1β刺激ヒト歯根膜細胞の炎症性サイトカイン産生を抑制する,
第140回日本歯科保存学会春季学術大会, Jun. 2014.
14.Kitanaka Yutaro, Yoshitaka Hosokawa, Ikuko Hosokawa, Shindo Satoru, Kazumi Ozaki and Takashi Matsuo :
genipinはTNF-αが誘導するヒト歯根膜由来細胞のIL-6産生を抑制する,
第57回春季歯周病学会学術大会, May 2014.
15.進藤 智, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
GenipinはIL-1betaが誘導するヒト歯根膜細胞のCCL20およびIL-6 産生を抑制する,
第139回日本歯科保存学会秋季学術大会, Oct. 2013.
16.Satoru Shindo, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo :
The effect of genipin on CCL20 and IL-6 productions from IL-1beta-stimulated human periodontal ligament cells,
The Japanese Journal of Conservative Dentistry, 70, Oct. 2013.
17.Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo :
IL-6 enhances CCL20 production from IL-1-stimulated human periodontal ligament cells,
Journal of the Japanese Association of Periodontology, 97, May 2013.
18.Ikuko Hosokawa, Yoshitaka Hosokawa, Kazumi Ozaki and Takashi Matsuo :
The effect of adrenomedullin on Th17-related cytokines production from human dendrtic cells,
The Japanese Journal of Conservative Dentistry, Nov. 2012.
19.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
The effect of IL-17A on CCL20 production from TNF-a-stimulated human gingival fibroblasts,
日本歯科保存学雑誌, Nov. 2012.
20.石川 真琴, Kaya Yoshida, Natsumi Fujiwara, Yoshitaka Hosokawa, Ikuko Hosokawa and Kazumi Ozaki :
歯周病原性細菌Porphyromonas gingivalis感染が肝臓糖代謝に及ぼす影響,
日本歯科保存学雑誌, 155, Nov. 2012.
21.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo :
The effect of catechin on CCL11 production from TNF-alpha -stimulated human gingival fibroblasts,
The Japanese Journal of Conservative Dentistry, Jun. 2012.
22.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
The effect of IL-22 on CCL20 production in IL-1beta-stimulated human gingival fibroblasts,
Journal of the Japanese Association of Periodontology, May 2012.
23.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Tadashi Nakanishi and Takashi Matsuo :
The effect of TWEAK on CCL20 production on IL-1beta-stimulated human gingival fibroblasts,
The Japanese Journal of Conservative Dentistry, Oct. 2011.
24.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo :
The effect of theaflavin on IL-6 production in TNFSF14-stimulated human gingival fibroblasts,
The Japanese Journal of Conservative Dentistry, Jun. 2011.
25.Kazumi Ozaki, Natsumi Fujiwara, 石川 真琴, 細川 育子, Yoshitaka Hosokawa and Hiromichi Yumoto :
う蝕関連細菌の家族内伝播と生活習慣による影響に関する研究 ―兄弟姉妹間の差異について―,
134回日本歯科保存学会春季学術大会, Jun. 2011.
26.Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
TLR3 ligandがヒト歯肉線維芽細胞のIL-1beta誘導CCL20産生に与える影響,
Journal of the Japanese Association of Periodontology, May 2011.
27.Shindo Satoru, Yoshitaka Hosokawa, Hosokawa Ikuko, Kazumi Ozaki, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo :
Oncostatin Mが誘導するヒト歯肉線維芽細胞のCXCL10産生に及ぼす紅茶ポリフェノールの影響,
Journal of the Japanese Association of Periodontology, May 2011.
28.Yoshitaka Hosokawa, Hosokawa Ikuko, Kazumi Ozaki, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo :
The effect of catechin on IL-6 production from TNFSF14-stimulated human gingival fibroblasts,
The Japanese Journal of Conservative Dentistry, Oct. 2010.
29.Hashimoto Reina, Yoshitaka Hosokawa, Hosokawa Ikuko, Kazumi Ozaki, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo :
IL-1betaが誘導するヒト歯肉線維芽細胞のCXCL10産生に及ぼす緑茶カテキンの影響,
Journal of the Japanese Association of Periodontology, Sep. 2010.
30.Yoshitaka Hosokawa, Hosokawa Ikuko, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
IL-17A enhances CCL20 production in IL-1beta-stimulated human gingival fibroblasts,
Journal of the Japanese Association of Periodontology, May 2010.
31.Ikuko Hosokawa, Yoshitaka Hosokawa, Kazumi Ozaki, Hiromichi Yumoto, Hideaki Nakae and Takashi Matsuo :
Proinflammatory Roles of NOD2 in Human Gingival Fibroblasts,
第55回 国際歯科研究学会日本部会(JADR)総会・学術大会, Nov. 2007.
32.Yoshitaka Hosokawa, 細川 育子, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
ヒト歯肉線維芽細胞におけるCCL17産生の解析,
第50回 春季日本歯周病学会学術大会, May 2007.
33.Yoshitaka Hosokawa, 細川 育子, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
サイトカイン刺激によるヒト歯肉線維芽細胞におけるCXCL16産生の解析,
第36回 日本免疫学会総会・学術集会, Dec. 2006.
34.Yoshitaka Hosokawa, 細川 育子, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
サイトカインがヒト歯肉線維芽細胞上のICAM-1およびVCAM-1発現に与える影響,
第49回 秋季日本歯周病学会学術大会, Oct. 2006.
35.Kayo Mukai, Tadashi Nakanishi, Yoshitaka Hosokawa, Kanako Takahashi and Takashi Matsuo :
カテキンが歯髄由来線維芽細胞の炎症性サイトカインおよび接着分子の発現誘導に与える影響,
第27回日本歯内療法学会学術大会, Jul. 2006.
36.Kayo Mukai, Tadashi Nakanishi, Yoshitaka Hosokawa, Kanako Takahashi, 足立 智彦 and Takashi Matsuo :
カテキンが歯髄由来線維芽細胞の炎症性サイトカインおよび接着分子の発現誘導に与える影響,
第124回日本歯科保存学会春季学術大会, May 2006.
37.Yoshitaka Hosokawa, 細川 育子, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
TWEAKがヒト歯肉線維芽細胞における炎症性サイトカイン産生ならびに接着分子発現に与える影響の解析,
第49回 春季日本歯周病学会学術大会, Apr. 2006.
38.Yoshitaka Hosokawa, 細川 育子, Hideaki Nakae, Kazumi Ozaki and Takashi Matsuo :
炎症性サイトカインおよびLPSはヒト歯肉線維芽細胞のCCL20産生を誘導する,
第48回 秋季日本歯周病学会学術大会, Sep. 2005.
39.細川 育子, Yoshitaka Hosokawa, Kazumi Ozaki and Takashi Matsuo :
Langerhans細胞における抗菌ペプチドの発現について,
第48回 秋季日本歯周病学会学術大会, Sep. 2005.
40.向井 佳代, Tadashi Nakanishi, Yoshitaka Hosokawa, Kanako Takahashi, 足立 智彦 and Takashi Matsuo :
Toll-like receptor リガンドによる歯髄由来繊維芽細胞のIL-8, VEGF, 接着分子発現誘導,
第122回春季日本歯科保存学会, Jun. 2005.
41.Kayo Mukai, Tadashi Nakanishi, Yoshitaka Hosokawa, Kanako Takahashi, 足立 智彦 and Takashi Matsuo :
Toll-like receptor リガンドによる歯髄線維芽細胞のIL-8,VEGF,接着分子の発現誘導,
第122回日本歯科保存学会春季学術大会, Jun. 2005.
42.Yoshitaka Hosokawa, 細川 育子, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
ヒト歯肉線維芽細胞におけるCXCL12産生ならびに機能的解析,
第47回 秋季日本歯周病学会学術大会, Oct. 2004.
43.Kanako Takahashi, Tadashi Nakanishi, Daisuke Yamaguchi, Yoshitaka Hosokawa, Hiromichi Yumoto, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
歯髄炎の病態形成におけるLARCおよびCCR6の役割,
第32回 日本免疫学会, Dec. 2002.
44.Daisuke Yamaguchi, Yoshitaka Hosokawa, Chihiro Shinohara, Hiromichi Yumoto, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo :
歯周炎病変局所におけるFractalkineおよびCX3CR1の発現,
第45回春季日本歯周病学会, Apr. 2002.
45.Yoshitaka Hosokawa, Tadashi Nakanishi, Daisuke Yamaguchi, Hirotoshi Shimizu, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
歯周炎病変局所におけるLARCおよびCCR6の発現,
第31回 日本免疫学会, Dec. 2001.
46.Daisuke Yamaguchi, Yoshitaka Hosokawa, Hiromichi Yumoto, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo :
歯周炎病変局所におけるIL-18とその機能に関連する分子の発現について,
第31回日本免疫学会学術集会, Dec. 2001.
47.Kanako Takahashi, Tadashi Nakanishi, Yoshitaka Hosokawa, Chihiro Shinohara, Hiromichi Yumoto, Kazumi Ozaki and Takashi Matsuo :
炎症歯髄におけるLARCおよびCCR6の発現,
第115回 秋季日本歯科保存学会, Nov. 2001.
48.Yoshitaka Hosokawa, Tadashi Nakanishi, Daisuke Yamaguchi, Hirotoshi Shimizu, Hiromichi Yumoto, Kazumi Ozaki and Takashi Matsuo :
歯周炎病変局所におけるLARCおよびCCR6の発現,
第44回 秋季日本歯周病学会学術大会, Oct. 2001.
49.Daisuke Yamaguchi, Yoshitaka Hosokawa, Hirotoshi Shimizu, Chihiro Shinohara, Hiromichi Yumoto, Tadashi Nakanishi and Takashi Matsuo :
歯周炎の病変局所におけるIL-18およびIL-18レセプターの発現,
第44回春季日本歯周病学会学術大会, Apr. 2001.
50.Yoshitaka Hosokawa, 山口 大輔, 清水 洋利, Tadashi Nakanishi, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
歯周炎の病巣局所におけるケモカインおよびケモカイン受容体の発現,
第30回 日本免疫学会総会, Nov. 2000.
51.Hirotoshi Shimizu, Yoshitaka Hosokawa, Daisuke Yamaguchi, Tadashi Nakanishi, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo :
歯周炎の病巣局所におけるリンパ球浸潤に対するケモカインの関与,
第29回 日本免疫学会総会, Dec. 1999.
52.Hirotoshi Shimizu, Yoshitaka Hosokawa, Tadashi Nakanishi, Kazumi Ozaki and Hideaki Nakae :
歯周炎の病巣局所におけるVCAM-1,VLA-4を介する接着系の解析,
第28回 日本免疫学会, Dec. 1998.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 柑橘類果皮含有生理活性物質を歯周炎治療に用いるための基礎的研究 (Project/Area Number: 19K10151 )
  • 口腔バイオフィルムの分散能と抗菌能を有する光触媒・ポリフェノール合剤の新規開発 (Project/Area Number: 19K10132 )
  • 香辛料含有成分を歯周炎治療に用いるための基礎的研究-ローズマリーに着目して- (Project/Area Number: 18K09600 )
  • 歯周炎病変局所における炎症性骨吸収に関与する白血球浸潤機構の解析 (Project/Area Number: 16K11834 )
  • ポリフェノール・銀ナノ粒子複合体を応用した口腔バイオフィルム形成制御技術の開発 (Project/Area Number: 16K11554 )
  • role of melatonin in periodontal disease (Project/Area Number: 15K11392 )
  • Analysis of mechanism for pro-inflammatory and anti-inflammatory balance and role of Th17 cells in pulpitis (Project/Area Number: 15K11115 )
  • Analysis of Th17 cells migration and activation in periodontally diseased tissues (Project/Area Number: 25463219 )
  • Study of the effects of serine proteases on the cariogenicity of Streptococcus mutans (Project/Area Number: 25462962 )
  • Analysis of a balance between pro-inflammatory and anti-inflammatory pulpal responses in the pathogenesis of pulpitis (Project/Area Number: 24592871 )
  • Analysis of Th17 cells migration inperiodontally diseased tissues. (Project/Area Number: 23792479 )
  • Study of the effects of adrenomedullin upon oral biofilm formation (Project/Area Number: 22592122 )
  • Analysis of Th17 cells migration and activation in periodontally diseased tissues. (Project/Area Number: 21792123 )
  • Development of the diagnosis and treatment of root caries on its pathosis and pathogenesis (Project/Area Number: 20592229 )
  • Study on a therapeutic application of tea catechins to vital pulp treatment. (Project/Area Number: 20592228 )
  • Roles of chemokines on lymphocytes migration inperiodontally diseased tissues (Project/Area Number: 19791616 )
  • ケモカインからみた歯周組織破壊におけるリンパ球浸潤メカニズムの解析 (Project/Area Number: 17791556 )
  • Study on synthesizing of intracellular polysaccharide by Streptococcus mutans in dentinal tubules. (Project/Area Number: 17591993 )
  • Analysis of the role of pulp fibroblasts on lymphocytes infiltration in pulpitis (Project/Area Number: 16591915 )
  • Search by Researcher Number (90346601)