Tokushima University / Educator and Researcher Directory --- Fukui, Makoto

Personal Web Page

https://researchmap.jp/read0088382 (researchmap)

Field of Study

○	Preventive Dentistry

Subject of Study

○	歯周病原性細菌の病原因子および歯周病患者由来唾液中分泌型IgAに関する研究 (歯周病原性, 病原因子, 唾液分泌型IgA)

Book / Paper

Academic Paper (Judged Full Paper):

1.	Masami Yoshioka, Hiromi Nakae, Makoto Fukui, Shizuko Yanagisawa, Yuka Sogawa, Harumi Sakamoto and Daisuke Hinode : 歯磨き習慣と関連付けたYouTube動画の制作と視聴による教育的効果の検討, Journal of Dental Health, Vol.73, No.3, 205-212, 2023.
2.	Masami Yoshioka, Yoshihiko Noma, Yuichiro Kawashima, Makoto Fukui, Hiromi Nakae, Hiromi Nakae, Shizuko Yanagisawa, Yasuhiko Shirayama and Daisuke Hinode : Factors associated with diabetes control: 2-Year cohort study in outpatients with type 2 diabetes, The Journal of Medical Investigation : JMI, Vol.70, No.1,2, 28-33, 2023. (Summary) Type 2 diabetes is a typical lifestyle disease. We aimed to identify the factors affecting glycemic control in 64 outpatients with type 2 diabetes over a 2-year period. We defined poor glycemic control using a change in glycosylated hemoglobin (?HbA1c) of ??0.5% over 2 years and/or HbA1c ??7.5% at the end of the study period. We used a questionnaire to collect information on oral health behavior and lifestyle, including eating and smoking habits, and analyzed the relationships between indices of diabetes control and responses to the questionnaire. The mean (SD) HbA1c of the participants was 6.87% (0.77%) at a baseline, and 6.93% (0.69%) after 2 years. Twenty-three participants (36.0%) had poor glycemic control. ?HbA1c and the change in body mass index (?BMI) correlated (Spearman's rank correlation, r?=?0.350, p?<?0.01). The HbA1c at baseline was associated with eating slowly?/?chewing well, and ?BMI was associated with perceived oral symptoms. Binominal logistic regression analysis revealed that poor glycemic control was associated with ?BMI and a smoking habit (odds ratio : 1.62, 95% confidence interval : 1.08?2.42?;?and 4.01, 1.12?14.36, respectively). These findings imply that weight gain and a smoking habit are associated with poor glycemic control in patients with type 2 diabetes. J. Med. Invest. 70 : 28-33, February, 2023. (Keyword) Humans / Diabetes Mellitus, Type 2 / Glycated Hemoglobin / Cohort Studies / Blood Glucose / Outpatients / Hyperglycemia (Tokushima University Institutional Repository) ● Metadata: 118298 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.28 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164734 ● Search Scopus @ Elsevier (PMID): 37164734 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.28 (Tokushima University Institutional Repository: 118298, DOI: 10.2152/jmi.70.28, PubMed: 37164734)
3.	Harumi Sakamoto, Makoto Fukui, Tokiko Doi, Masami Yoshioka and Daisuke Hinode : Factors influencing dental caries in 3-year-old children: Effectiveness through prenatal oral health examination on the behavioral change, Journal of Dental Health, Vol.73, No.1, 31-41, 2023. (Tokushima University Institutional Repository) ● Metadata: 118192 (Tokushima University Institutional Repository: 118192)
4.	KUBO Eri, Makoto Fukui, Harumi Sakamoto and Daisuke Hinode : Analysis of Factors Related to Periodontal Condition in Pregnant Women, Journal of Dental Health, Vol.73, No.1, 21-30, 2023. (Keyword) 妊婦 / 歯周状態 / かかりつけ歯科医 / 補助的清掃用具 / Pregnant women / Periodontal condition / Family dentist / Adjunctive oral hygiene device (Tokushima University Institutional Repository) ● Metadata: 118218 (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.73.1_21 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390858066754105344 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.73.1_21 (Tokushima University Institutional Repository: 118218, DOI: 10.5834/jdh.73.1_21, CiNii: 1390858066754105344)
5.	Rei Kasai, Makoto Fukui, Shizuko Yanagisawa and Kosuke Kataoka : 1,450 ppmフッ化物配合歯磨剤によるブラッシング後の安静時唾液中フッ化物イオンの残存状況に関する報告, Journal of Dental Health, Vol.72, No.3, 173-177, 2022.
6.	Yoshiko Yamamura, Makoto Fukui, Takaharu Kudoh, 横田美保, Kumiko Kamada, Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : ピロカルピン塩酸塩を用いた口腔リンス法の有用性と安全性の検討, 日本口腔ケア学会誌, Vol.16, No.2, 52-56, 2022.
7.	Makoto Fukui, Asakuma Hiroki, Horiuchi Hiroko, Takii Hiroshi, Masami Yoshioka and Daisuke Hinode : Oral care tablet containing kiwifruit powder affects tongue coating microbiome, Clinical and Experimental Dental Research, Vol.8, No.3, 721-728, 2022. (Tokushima University Institutional Repository) ● Metadata: 118598 (Link to Publication Site) ● Publication site (DOI): 10.1002/cre2.591 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1002/cre2.591 (Tokushima University Institutional Repository: 118598, DOI: 10.1002/cre2.591)
8.	Kumiko Sahara, Makoto Fukui, Harumi Sakamoto, Tokiko Doi, Masami Yoshioka, 岡本好史, 松本侯, Miwa Matsuyama, Fumiaki Kawano and Daisuke Hinode : 後期高齢者の口腔状態と要介護認定または死亡発生との関連性, Journal of Dental Health, Vol.72, No.2, 106-114, 2022. (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.72.2_106 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.72.2_106 (DOI: 10.5834/jdh.72.2_106)
9.	Masami Yoshioka, 川島友一郎, Makoto Fukui, Shizuko Yanagisawa, Hiromi Nakae, Yuka Sogawa and Daisuke Hinode : 糖尿病患者における間食習慣および口腔保健行動と口腔環境との関連性, Journal of Dental Health, Vol.71, No.4, 215-222, 2021. (Keyword) 糖尿病 / 間食習慣 / 口腔保健行動 / 口腔環境 / 多項目唾液検 / Diabetes / Snacking habit / Oral health behavior / Oral environment / Salivary multi-test system / トウニョウビョウ / カンショクシュウカン / コウコウホケンコウドウ / コウコウカンキョウ / タコウモクダエキケン (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520009410453382528 (CiNii: 1520009410453382528)
10.	Masami Yoshioka, Yuichiro Kawashima, Yoshihiko Noma, Makoto Fukui, Shizuko Yanagisawa, Yasuhiko Shirayama, Kojiro Nagai and Daisuke Hinode : Association between Diabetes-related Clinical Indicators and Oral Health Behavior among Type-2 Diabetes Patients, The Journal of Medical Investigation : JMI, Vol.68, No.1,2, 140-147, 2021. (Summary) Objective : The aim of this study was to evaluate the association between diabetes-related indicators and oral health behavior among patients with type 2 diabetes. Methods : Seventy-four outpatients were included. We administered a questionnaire and divided the patients into two groups according to oral health behavior and eating habits. We then compared diabetes-related clinical records between the groups and performed logistic regression analysis. Results : Participants who brushed their teeth before bedtime every night had lower BMIs than those who did not. Participants who reported eating slowly and chewing well every day had significantly lower HbA1c than their counterparts. Participants who reported gum bleeding had significantly higher LDL-cholesterol than their counterparts. Binominal logistic regression analysis revealed that BMI < 25 was associated with not brushing teeth before bedtime every night, HbA1c < 7.5 with not eating slowly or chewing well every day, and LDL-cholesterol < 120 with gum bleeding (odds ratio : 0.140, 95% confidence interval : 0.036-0.540 ; OR : 0.085, 95% CI : 0.010-0.736, OR : 0.275, 95% CI : 0.077-0.979, respectively). Conclusions : Our findings suggest that toothbrushing before bedtime every night is associated with reduced risk of obesity and that eating slowly and chewing well are advantageous for glycemic control in patients with type 2 diabetes.J. Med. Invest. 68 : 140-147, February, 2021. (Keyword) Body Mass Index / Diabetes Mellitus, Type 2 / Feeding Behavior / Health Behavior / Humans / Toothbrushing (Tokushima University Institutional Repository) ● Metadata: 116003 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.68.140 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33994459 ● Search Scopus @ Elsevier (PMID): 33994459 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.140 (Tokushima University Institutional Repository: 116003, DOI: 10.2152/jmi.68.140, PubMed: 33994459)
11.	Tokiko Doi, Makoto Fukui, Harumi Sakamoto, Hiromi Nakae, Junji Komoda, Omar Maningo Rodis and Daisuke Hinode : There is an association between gingival inflammation and obesity in Japanese male adolescents, Journal of Oral Health and Biosciences, Vol.33, No.2, 29-34, 2021. (Keyword) Gingival inflammation / obesity / Lifestyle habits / Adolescents / Cohort study (Tokushima University Institutional Repository) ● Metadata: 115636 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.33.2_33 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1391412881287168000 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.33.2_33 (Tokushima University Institutional Repository: 115636, DOI: 10.20738/johb.33.2_33, CiNii: 1391412881287168000)
12.	Yuka Sogawa, Makoto Fukui, Shingen Nakamura, Kimiko Sogabe, Ryohei Sumitani, Masami Yoshioka, Masahiro Abe and Daisuke Hinode : Involvement of oral bacteria and oral immunity as risk factors for chemotherapy- induced fever with neutropenia in patients with hematological cancer, International Journal of Hematology, Vol.112, No.6, 851-859, 2020. (Summary) The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject were assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the Cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98, p < 0.05) and the rate of Fusobacterium nucleatum [F. nucleatum count per total bacterial count (%)] was high (HR 1.65, p < 0.05) in patients with FwN onset. Using ROC curve analysis, the optimal cutoff point based on the AUC in the F. nucleatum/sIgA ratio was 0.023, and this model had a 78.4% probability (p < 0.01). The risk of FwN onset was also significantly higher among the group of ≥ 0.023 F. nucleatum/sIgA ratio (HR 66.06, p < 0.01). These results suggest that the rate of F. nucleatum and the levels of sIgA at baseline might be related to FwN onset as risk factors. (Keyword) Adult / Aged / Aged, 80 and over / Antineoplastic Agents / Bacterial Load / Febrile Neutropenia / female / Fusobacterium nucleatum / Hematologic Neoplasms / Humans / Immunoglobulin A, Secretory / male / Middle Aged / Mouth / Risk Factors / Young Adult (Tokushima University Institutional Repository) ● Metadata: 115932 (Link to Publication Site) ● Publication site (DOI): 10.1007/s12185-020-02975-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32880823 ● Summary page in Scopus @ Elsevier: 2-s2.0-85090162636 (Tokushima University Institutional Repository: 115932, DOI: 10.1007/s12185-020-02975-x, PubMed: 32880823, Elsevier: Scopus)
13.	Minami Watanabe, Harumi Sakamoto, Makoto Fukui, Masami Yoshioka and Daisuke Hinode : Relationship between smoking habits of mothers and dental health behavior or the oral health condition of their children, Japanese Journal of Smoking Control Science, Vol.14, No.10, 1-7, 2020. (Summary) Objective: It is known that secondhand smoke exposure is associated with dental caries in children, and it is also speculated that mothers with smoking habits may have little awareness of their dental health and their children. The purpose of this study was to analyze the relationship between smoking habits of mothers and dental health behavior or the oral health condition of their children, and to clarify the factors involved in dental caries of deciduous teeth.Methods: The subjects enrolled in this study were mothers and their children who received health checkup for both 18-month-old children and 3-year-old children in N City, Tokushima Prefecture, Japan. One hundred sixty-five subjects (mothers) were divided into two groups, non-smoker group (n=152) and smoker group (n=13). The results of dental examinations for 3-year-old children and the questionnaire surveys from mothers were collated and analyzed.Results: Dental caries prevalence of deciduous teeth was 46.2% in children of the smoker group, which was significantly higher than that of 21.1% in children of the non-smoker group (p<0.05). Among the questionnaire survey items regarding the regular dental checkup of mothers, the percentage of "no visit" in the smoker group was 76.9% and 46.1% in the non-smoker group, and it showed a significant difference (p<0.05). In the item of the dental examination for pregnant woman, the percentage of "did not receive" in the smoker group was 76.9% and 43.7% in the non-smoker group, and it showed a significant difference (p<0.05). There were significant differences between the presence and absence of smoking habits of mothers regarding the age of mother (p<0.01) and smoking habits of the other families (p<0.05). In addition, the binomial logistic regression analysis showed that oral hygiene condition (OR=2.92, p<0.05), regular between meal eating (OR=3.99, p<0.01) and smoking habits of mothers (OR=4.13, p<0.05) were significantly corelated with the presence of dental caries in 3-year-old children.Conclusions: These results suggest that the mothers in the smoking group was younger and higher rate that included smoker families, in addition to poor regular dental check-up during pregnancy and currently. It was also suggested that smoking habits of mothers were associated with dental caries in 3-year-old children. (Keyword) Pregnant women / Smoking / Dental caries of deciduous teeth / Maternal and child health (Tokushima University Institutional Repository) ● Metadata: 116173 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390006585527134720 (Tokushima University Institutional Repository: 116173, CiNii: 1390006585527134720)
14.	Masami Yoshioka, Yoshifumi Okamoto, Masahiro Murata, Makoto Fukui, Shizuko Yanagisawa, Yasuhiko Shirayama, Kojiro Nagai and Daisuke Hinode : Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men, Journal of Diabetes Research, Vol.2020, 4042129, 2020. (Tokushima University Institutional Repository) ● Metadata: 115663 (Link to Publication Site) ● Publication site (DOI): 10.1155/2020/4042129 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1155/2020/4042129 (Tokushima University Institutional Repository: 115663, DOI: 10.1155/2020/4042129)
15.	Matsumura Yuki, Daisuke Hinode, Makoto Fukui, Masami Yoshioka, Asakuma Hiroki and Takii Hiroshi : Effectiveness of an oral care tablet containing kiwifruit powder in reducing oral bacteria in tongue coating: A crossover trial, Clinical and Experimental Dental Research, Vol.6, No.2, 197-206, 2020. (Summary) The aim of this study was to investigate the effect of an oral care tablet containing kiwifruit powder on oral bacteria in tongue coating compared with tongue brushing. Thirty-two healthy, young adults were enrolled, and a crossover clinical trial was conducted. The volatile sulfur compound (VSC) concentration, Winkel tongue-coating index (WTCI), and the number of total bacteria in addition to Fusobacterium nucleatum in tongue coating were measured. We instructed subjects to remove tongue coating by tongue brush for Intervention I, to keep the oral care tablet containing kiwifruit powder on the tongue dorsum and to let it dissolve naturally for Intervention II, and three oral care tablets 1 day before the measurement for Intervention III. There were significant differences in terms of the level of H S, VSC, and WTCI at Intervention I and all evaluation values at Intervention II. There were significant differences in terms of the level of H S, VSC, WTCI, the number of total bacteria, and F. nucleatum at Intervention III. The value of WTCI, the number of bacteria, and F. nucleatum decreased significantly after taking the oral care tablets than after tongue brushing. When compared with Interventions I and III, Intervention III showed the effective results; there were significant differences in the number of total bacteria and F. nucleatum between tongue brushing and taking tablets. These results suggested that the oral care tablet containing kiwifruit powder could be effective in reducing total bacteria and F. nucleatum in tongue coating when compared with tongue brushing. (Tokushima University Institutional Repository) ● Metadata: 115838 (Link to Publication Site) ● Publication site (DOI): 10.1002/cre2.262 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32250572 ● Summary page in Scopus @ Elsevier: 2-s2.0-85076095991 (Tokushima University Institutional Repository: 115838, DOI: 10.1002/cre2.262, PubMed: 32250572, Elsevier: Scopus)
16.	Michiyasu Nakao, Nanako Nishikiori, Akihito Nakamura, Murasaki Miyagi, Nao Shibata, Syuji Kitaike, Makoto Fukui, Hiro-O Ito and Shigeki Sano : Synthesis of Sterically Protected Isoindoles from ortho-Phthalaldehyde, SynOpen, Vol.2, No.1, 50-57, 2018. (Summary) o-Phthalaldehyde (OPA) reacts with O-protected tris(hydroxyalkyl)aminomethanes in the presence of 1-propanethiol to afford a novel class of stable isoindoles. Steric protection provided by the bulkiness of C 3-symmetric primary amines derived from tris(hydroxymethyl)aminomethane could be significant for the stabilization of 1-alkylthio-2-alkyl-substituted isoindoles derived from OPA. A plausible reaction mechanism is proposed to explain the formation of the isoindole and an isoindolin-1-one by-product. (Keyword) o-phthalaldehyde / isoindole / steric protection / isoindolin-1-one (Tokushima University Institutional Repository) ● Metadata: 113941 (Link to Publication Site) ● Publication site (DOI): 10.1055/s-0036-1591932 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1055/s-0036-1591932 (Tokushima University Institutional Repository: 113941, DOI: 10.1055/s-0036-1591932)
17.	Naofumi Tamaki, 松尾亮, 水野昭彦, 正木文浩, 中川徹, 鈴木雅博, Makoto Fukui, 谷口隆司, 三宅達郎 and Hiro-O Ito : 歯肉溝液中の炎症関連バイオマーカーと糖尿病・腎機能マーカーとの関連性, Journal of Dental Health, Vol.66, No.3, 316-321, 2016. (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.66.3_316 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205002850304 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.66.3_316 (DOI: 10.5834/jdh.66.3_316, CiNii: 1390001205002850304)
18.	Naofumi Tamaki, Rita Cristina Orihuela Campos, Makoto Fukui and Hiro-O Ito : Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model., Oxidative Medicine and Cellular Longevity, Vol.2016, 5679040, 2016. (Summary) The wound healing process attempts to restore the integrity and function of the injured tissue. Additionally, proinflammatory cytokines, growth factors, and oxidative stress play important roles in wound healing. The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory cytokine levels and promoting healing-associated genes. A circular excisional wound was created in the oral palatal region, and the wound healing process was observed. The rats were divided into two experimental groups in which either hydrogen-rich water or distilled water was consumed. In the drinking hydrogen-rich water, the palatal wound healing process was accelerated compared to that in the control group. As molecular hydrogen upregulated the Nrf2 pathway, systemic oxidative stresses were decreased by the activation of antioxidant activity. Furthermore, hydrogen-rich water intake reduced proinflammatory cytokine levels and promoted the expression of healing-associated factors in rat palatal tissue. In conclusion, hydrogen-rich water intake exhibited multiple beneficial effects through activation of the Nrf2/antioxidant defense pathway. The results of this study support the hypothesis that oral administration of hydrogen-rich water benefits the wound healing process by decreasing oxidative stress and inflammatory responses. (Keyword) Animals / Antioxidants / Biomarkers / Chemokines / Disease Models, Animal / Drinking Behavior / Gene Expression Regulation / Hydrogen / Inflammation Mediators / Male / NF-E2-Related Factor 2 / Nitric Oxide Synthase Type II / Oxidative Stress / Palate / Rats, Wistar / Real-Time Polymerase Chain Reaction / Signal Transduction / Water / Wound Healing (Tokushima University Institutional Repository) ● Metadata: 109746 (Link to Publication Site) ● Publication site (DOI): 10.1155/2016/5679040 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26798423 ● Search Scopus @ Elsevier (PMID): 26798423 ● Search Scopus @ Elsevier (DOI): 10.1155/2016/5679040 (Tokushima University Institutional Repository: 109746, DOI: 10.1155/2016/5679040, PubMed: 26798423)
19.	S Hayashi, Hirotsugu Yamada, Makoto Fukui, Hiro-O Ito and Masataka Sata : Correlation between arteriosclerosis and periodontal condition assessed by lactoferrin and [alpha]1-antitrypsin levels in gingival crevicular fluid., International Heart Journal, Vol.56, No.6, 639-643, 2015. (Summary) Patients with periodontal disease exhibit exacerbated atherosclerosis, aortic stiffness, or vascular endothelial dysfunction. However, in a recent scientific statement, the American Heart Association noted that neither has periodontal disease been proven to cause atherosclerotic vascular disease nor has the treatment of periodontal disease been proven to prevent atherosclerotic vascular disease. Therefore, the aim of the present study was to examine the correlation between periodontal condition and arteriosclerosis in patients with coronary artery disease (CAD), which is usually accompanied by systemic arteriosclerosis.We measured levels of gingival crevicular fluid lactoferrin (GCF-Lf) and 1-antitrypsin (GCF-AT) in 72 patients (67 ± 8 years, 56 men) with CAD. Furthermore, we evaluated the maximum intima-media thickness (max IMT) and plaque score of the carotid arteries as well as brachial-ankle pulse wave velocity (baPWV) and flow-mediated dilation (FMD) of the brachial artery, each of which is a parameter for determining arteriosclerosis status. The average level of GCF-Lf was 0.29 ± 0.36 µg/mL and that of GCF-AT was 0.31 ± 0.66 µg/mL, with significant correlation between the two (r = 0.701, P < 0.001). No significant difference in GCF-Lf and GCF-AT levels was observed between patients with single-, double-, and triple-vessel CAD. There were no significant correlations between the arteriosclerosis parameters (ie, max IMT, plaque score, baPWV, and FMD) and GCF-Lf or GCF-AT.No correlation between the GCF biomarkers and the severity of arteriosclerosis was detected. This result may suggest that worsening of the periodontal condition assessed by GCF biomarkers is not a major potential risk factor for arteriosclerosis. (Keyword) Periodontal disease / Coronary artery disease / Atherosclerosis (Link to Publication Site) ● Publication site (DOI): 10.1536/ihj.15-218 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26549390 ● Search Scopus @ Elsevier (PMID): 26549390 ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.15-218 (DOI: 10.1536/ihj.15-218, PubMed: 26549390)
20.	Naofumi Tamaki, Fumihiko Yoshino, Makoto Fukui, Hideaki Hayashida, Ayaka Yoshida, Masayasu Kitamura, Takahiro Iwasaki, Reiko Furugen, Koji Kawasaki, Mio Nakazato, Takahiro Maeda, Susumu Kokeguchi, Tatsuo Yamamoto, Chang-Il Masaichi Lee, Hiro-O Ito and Toshiyuki Saito : Relationship among salivary antioxidant activity, cytokines and periodontitis: the Nagasaki Island study., Journal of Clinical Periodontology, Vol.42, No.8, 711-718, 2015. (Summary) These findings suggest that the evaluation of salivary antioxidant activities, as assessed by electron spin resonance, are associated with periodontitis and various clinical variables in community-dwelling participants (ClinicalTrials. gov number NCT01742728). This article is protected by copyright. All rights reserved. (Link to Publication Site) ● Publication site (DOI): 10.1111/jcpe.12438 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26227009 ● Summary page in Scopus @ Elsevier: 2-s2.0-84941261275 (DOI: 10.1111/jcpe.12438, PubMed: 26227009, Elsevier: Scopus)
21.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Rie Mukai, Makoto Fukui, Kaname Miki, Junji Terao and Hiro-O Ito : Biological impacts of resveratrol, quercetin, and N-acetylcysteine on oxidative stress in human gingival fibroblasts., Journal of Clinical Biochemistry and Nutrition, Vol.56, No.3, 220-227, 2015. (Summary) In periodontitis, production of reactive oxygen species (ROS) by neutrophils induces oxidative stress and deteriorates surrounding tissues. Antioxidants reduce damage caused by ROS and are used to treat diseases involving oxidative stress. This study summarizes the different effects of resveratrol, quercetin, and N-acetylcysteine (NAC) on human gingival fibroblasts (HGFs) under oxidative stress induced by hydrogen peroxide. Real-time cytotoxicity analyses reveals that resveratrol and quercetin enhanced cell proliferation even under oxidative stress. Of the antioxidants tested, resveratrol is the most effective at inhibiting ROS production. HGFs incubated with resveratrol and quercetin up-regulate the transcription of type I collagen gene after 3 h, but only resveratrol sustained this up-regulation for 24 h. A measurement of the oxygen consumption rate (OCR, mitochondrial respiration) shows that resveratrol generates the highest maximal respiratory capacity, followed by quercetin and NAC. Simultaneous measurement of OCR and the extracellular acidification rate (non-mitochondrial respiration) reveals that resveratrol and quercetin induce an increase in mitochondrial respiration when compared with untreated cells. NAC treatment consumes less oxygen and enhances more non-mitochondrial respiration. In conclusion, resveratrol is the most effective antioxidant in terms of real-time cytotoxicity analysis, reduction of ROS production, and enhancement of type I collagen synthesis and mitochondrial respiration in HGFs. (Tokushima University Institutional Repository) ● Metadata: 109399 (Link to Publication Site) ● Publication site (DOI): 10.3164/jcbn.14-129 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26060353 ● Summary page in Scopus @ Elsevier: 2-s2.0-84929618900 (Tokushima University Institutional Repository: 109399, DOI: 10.3164/jcbn.14-129, PubMed: 26060353, Elsevier: Scopus)
22.	Naofumi Tamaki, Rita Cristina Orihuela Campos, Yuji Inagaki, Makoto Fukui, Toshihiko Nagata and Hiro-O Ito : Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model., Free Radical Biology and Medicine, Vol.75, 222-229, 2014. (Summary) Oxidative stress is a key factor regulating the systemic pathophysiological effects associated with periodontitis. Resveratrol is a phytochemical with antioxidant and anti-inflammatory properties that can reduce oxidative stress and inflammation. We hypothesized that resveratrol may prevent the progression of periodontitis and reduce systemic oxidative stress through the activation of the Sirtuin1 (Sirt1)/AMP-activated protein kinase (AMPK) and the nuclear factor-E2 related factor 2 (Nrf2)/antioxidant defense pathways. Three groups of male Wistar rats (periodontitis treated with melinjo resveratrol, periodontitis without resveratrol, and control rats with no periodontitis or resveratrol treatment) were examined. A ligature was placed around the maxillary molars for 3 weeks to induce periodontitis, and the rats were then given drinking water with or without melinjo resveratrol. In rats with periodontitis, ligature placement induced alveolar bone resorption, quantified using three-dimensional images taken by micro-CT, and increased proinflammatory cytokine levels in gingival tissue. Melinjo resveratrol intake relieved alveolar bone resorption and activated the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in inflamed gingival tissues. Further, melinjo resveratrol improved the systemic levels of 8-hydroxydeoxyguanosine, dityrosine, nitric oxide metabolism, nitrotyrosine, and proinflammatory cytokines. We concluded that oral administration of melinjo resveratrol may prevent the progression of ligature-induced periodontitis and improve systemic oxidative and nitrosative stress. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.freeradbiomed.2014.07.034 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25091897 ● Search Scopus @ Elsevier (PMID): 25091897 ● Search Scopus @ Elsevier (DOI): 10.1016/j.freeradbiomed.2014.07.034 (DOI: 10.1016/j.freeradbiomed.2014.07.034, PubMed: 25091897)
23.	Naofumi Tamaki, H Hayashida, Makoto Fukui, M Kitamura, K Kawasaki, M Nakazato, T Maeda, T Saito and Hiro-O Ito : Oxidative stress and antibody levels to periodontal bacteria in adults: the Nagasaki Islands study., Oral Diseases, Vol.20, No.3, 49-56, 2014. (Summary) OBJECTIVE: Periodontitis is a chronic inflammatory disease of the tissues supporting the teeth and is caused by subgingival plaque. Systemic increases in reactive oxygen species are involved in pathogenesis of periodontitis. This study addressed the relationship between levels of serum oxidative stress and antibodies against putative periodontopathic bacteria and their association with periodontal conditions, in a community-based study. SUBJECTS AND METHODS: Serum samples were measured for reactive oxygen metabolite (ROM) levels and anti-oxidant capacity. The serum levels of immunoglobulin G (IgG) antibodies to Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Aggregatibacter actinomycetemcomitans (Aa), and Eikenella corrodens (Ec) were determined by ELISA. RESULTS: The participants with greater clinical attachment loss had higher serum ROM levels and IgG antibody titers to Pg. Serum ROM levels were positively correlated with antibody titers to Pg, Pi, and Ec. When the participants with greater probing pocket depth and clinical attachment loss were used as the dependent variables, high ROM levels showed a statistically significant associations in multivariate logistic analyses; the adjusted odds ratios were 2.9 (95% confidence interval = 1.0-8.5) and 6.0 (95% confidence interval = 2.0-17.6), respectively. CONCLUSIONS: It was concluded that an increased oxidative stress may be detrimental to periodontitis in Japanese community-dwelling adults. (Link to Publication Site) ● Publication site (DOI): 10.1111/odi.12127 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23679350 ● Summary page in Scopus @ Elsevier: 2-s2.0-84896099990 (DOI: 10.1111/odi.12127, PubMed: 23679350, Elsevier: Scopus)
24.	Masaki GOTO, Agnieszka Wilk, Kosuke Kataoka, Shirish Chodankar, Nobutake Tamai, Makoto Fukui, Joachim Kohlbrecher, Hiro-O Ito and Hitoshi Matsuki : Study on the Subgel-Phase Formation Using an Asymmetric Phospholipid Bilayer Membrane by High-Pressure Fluorometry, Langmuir, Vol.28, No.33, 12191-12198, 2012. (Summary) The myristoylpalmitoylphosphatidylcholine (MPPC) bilayer membrane shows a complicated temperature-pressure phase diagram. The large portion of the lamellar gel (L(β)'), ripple gel (P(β)'), and pressure-induced gel (L(β)I) phases exist as metastable phases due to the extremely stable subgel (L(c)) phase. The stable L(c) phase enables us to examine the properties of the L(c) phase. The phases of the MPPC bilayers under atmospheric and high pressures were studied by small-angle neutron scattering (SANS) and fluorescence spectroscopy using a polarity-sensitive fluorescent probe Prodan. The SANS measurements clearly demonstrated the existence of the metastable L(β)I phase with the smallest lamellar repeat distance. From a second-derivative analysis of the fluorescence data, the line shape for the L(c) phase under high pressure was characterized by a broad peak with a minimum of ca. 460 nm. The line shapes and the minimum intensity wavelength (λ''(min)) values changed with pressure, indicating that the L(c) phase has highly pressure-sensible structure. The λ''(min) values of the L(c) phase spectra were split into ca. 430 and 500 nm in the L(β)I phase region, which corresponds to the formation of a interdigitated subgel L(c) (L(c)I) phase. Moreover, the phase transitions related to the L(c) phase were reversible transitions under high pressure. Taking into account the fluorescence behavior of Prodan for the L(c) phase, we concluded that the structure of the L(c) phase is highly probably a staggered structure, which can transform into the L(c)I phase easily. (Keyword) 2-Naphthylamine / Atmospheric Pressure / Cell Membrane / Fluorometry / Gels / Lipid Bilayers / Neutron Diffraction / Phosphatidylcholines / Pressure / Scattering, Small Angle (Link to Publication Site) ● Publication site (DOI): 10.1021/la3020173 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22823885 ● Summary page in Scopus @ Elsevier: 2-s2.0-84865495527 (DOI: 10.1021/la3020173, PubMed: 22823885, Elsevier: Scopus)
25.	Tselmeg Baatarjav, Kosuke Kataoka, Rebekah S. Gilbert, Yutaka Terao, Makoto Fukui, Masaki GOTO, Shigetada Kawabata, Masato Yamamoto, Kohtaro Fujihashi and Hiro-O Ito : Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccination, Vaccine, Vol.29, No.34, 5747-5757, 2011. (Summary) Phosphorylcholine (PC) is an immunodominant epitope in some pathogens including Streptococcus pneumoniae and it is well-known that PC-specific antibodies (Abs) play a key role in the induction of protective immunity against pneumococcal infection. In this study, we examined whether nasal administration of DNA plasmid encoding Flt3 ligand gene (pFL) as a mucosal adjuvant plus PC-conjugated keyhole limpet hemocyanin (PC-KLH), would elicit PC-specific immune responses, and characterized mucosal immune responses to PC induced by this nasal vaccination. Nasal immunization with pFL plus PC-KLH enhanced induction of PC-specific IgA and IgM Abs in airway secretions when compared with mice given PC-KLH with or without empty plasmid gene (pORF) as controls; in addition to the mucosal immune responses, PC-specific immune responses in serum were also induced. Furthermore, the mucosal and serum IgA and IgM Abs in mice given pFL plus PC-KLH nasally, exhibited high-specificity for the PC molecule. Of interest, the PC-specific Abs bound dose-dependently to anti-T15 idiotype (AB1-2). Thus, the inhibition of S. pneumoniae colonization on the nasal cavity and lungs after nasal challenge with the live organism was significantly elicited in mice immunized with pFL plus PC-KLH compared to that of mice immunized with antigen with pORF. Taken together, these findings show that nasal administration of pFL with PC-KLH elicited T15-like anti-PC IgA and IgM Abs in the respiratory tracts, and further attenuated S. pneumoniae colonization on the respiratory tracts. Nasal administration of Flt3 ligand cDNA with PC may contribute to the development of nasal vaccination for prevention of S. pneumoniae infection. (Keyword) Administration, Intranasal / Administration, Mucosal / Animals / Antibodies, Bacterial / Bacterial Vaccines / DNA, Complementary / Hemocyanin / Immunity, Mucosal / Immunoglobulin A / Immunoglobulin M / Membrane Proteins / Mice / Mice, Inbred C57BL / Phosphorylcholine / Plasmids / Pneumococcal Infections / Streptococcus pneumoniae / Vaccines, DNA (Link to Publication Site) ● Publication site (DOI): 10.1016/j.vaccine.2011.05.097 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21683111 ● Summary page in Scopus @ Elsevier: 2-s2.0-79960560899 (DOI: 10.1016/j.vaccine.2011.05.097, PubMed: 21683111, Elsevier: Scopus)
26.	Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, Masami Yoshioka, Kosuke Kataoka and Hiro-O Ito : Levels of salivary stress markers in patients with anxiety about halitosis, Archives of Oral Biology, Vol.55, No.11, 842-847, 2010. (Summary) To investigate the relationship between salivary stress markers and mental stress states in patients complaining of oral malodour. The utility of the salivary stress markers in assessment of mental conditions of those patients was also investigated. The study population included 74 patients, aged 20-59 years, who complained of oral malodour and were referred to the Breath Odor Clinic at Tokushima University Hospital. Patients were classified into two groups, genuine halitosis (GH) and psychosomatic halitosis (PH), according to the results of organoleptic rating measurement. All patients were subjected to examination by the Cornell Medical Index (CMI) Health Questionnaire. Resting saliva was collected and levels of salivary IgA, cortisol and chromogranin A were determined by ELISA. Twenty-three volunteers not complaining of halitosis were included as the control group. Kruskal-Wallis test and Mann-Whitney's U-test were used for statistical analysis. A significant increase was observed in the concentrations of salivary cortisol in the PH group as compared with GH and control groups (p<0.05). Concentrations of IgA and chromogranin A in saliva were not significantly different among the three groups. In addition, higher salivary cortisol concentrations were found in CMI scale III and IV (tendency towards neurosis) than in scale I and II (normal) (p<0.05). Since salivary cortisol reflects a status of chronic stress condition, psychosomatic halitosis might be closely related to this state of chronic stress. Determination of cortisol levels in saliva may provide useful information for evaluating the mental status of patients complaining of halitosis. (Keyword) Adult / Anxiety / Biological Markers / Case-Control Studies / Chromogranin A / Enzyme-Linked Immunosorbent Assay / Female / Halitosis / Humans / Hydrocortisone / Immunoglobulin A / Male / Middle Aged / Psychophysiologic Disorders / Questionnaires / Saliva / Statistics, Nonparametric (Link to Publication Site) ● Publication site (DOI): 10.1016/j.archoralbio.2010.07.014 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20807658 ● Search Scopus @ Elsevier (PMID): 20807658 ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2010.07.014 (DOI: 10.1016/j.archoralbio.2010.07.014, PubMed: 20807658)
27.	Etsuhisa Takahashi, Kosuke Kataoka, Kazuyuki Fujii, Junji Chida, Dai Mizuno, Makoto Fukui, Hiro-O Ito, Kohtaro Fujihashi and Hiroshi Kido : Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus., Microbes and Infection, Vol.12, No.10, 778-783, 2010. (Summary) The antiviral neuraminidase inhibitor oseltamivir (OSV) is widely used to suppress viral replication in the treatment of influenza. Here, we report that OSV administration significantly suppressed respiratory mucosal secretory IgA responses with respect to antigen (Ag)-specific antibody (Ab) production and also the induction of Ag-specific IgA Ab-forming cells, but not systemic IgG responses, in weanling mice as a model of pediatric influenza. Neutralizing activities of the airway fluids in oral OSV-treated mice were significantly less than those of sham-treated mice. Our findings suggest the risk of re-infection in patients showing a low mucosal response following OSV treatment. (Keyword) Animals / Antibodies, Viral / Antiviral Agents / Female / Immunity, Mucosal / Immunoglobulin A / Immunoglobulin G / Immunosuppression / Immunosuppressive Agents / Influenza A virus / Mice / Mice, Inbred BALB C / Orthomyxoviridae Infections / Oseltamivir (Link to Publication Site) ● Publication site (DOI): 10.1016/j.micinf.2010.04.013 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20452454 ● Search Scopus @ Elsevier (PMID): 20452454 ● Search Scopus @ Elsevier (DOI): 10.1016/j.micinf.2010.04.013 (DOI: 10.1016/j.micinf.2010.04.013, PubMed: 20452454)
28.	Yuka Sogawa, Masaaki Yokoyama, Harumi Sakamoto, 幸江真杉, Makoto Fukui, Masami Yoshioka and Daisuke Hinode : The study of oral health promotion for pregnant women at Tokushima University Hospital, The Journal of Japan Society for Dental Hygiene, Vol.4, No.1, 50-57, 2009. (Keyword) 歯周疾患指数 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521699231068868224 (CiNii: 1521699231068868224)
29.	Masaaki Yokoyama, Makoto Fukui, Kaname Masuda, Natsuko Takamatsu, Jurou Okada, 裕光武部, Kosuke Kataoka and Hiro-O Ito : リアルタイム定量PCR(qPCR)法による唾液中の総細菌数の測定口腔清潔度の指標としての試み, Journal of Dental Health, Vol.59, No.3, 183-189, 2009. (Summary) The state of oral hygiene has been evaluated by employing various indices, such as the Oral Hygiene Index, Plaque Index, Patient Hygiene Performance, and Plaque Control Record (O'Leary's PCR). Measuring the scores of these indices is time- and labor-consuming, requiring manual reading and recording by professionals, standardization of examination methods. In contrast, measuring the total number of bacteria in saliva using quantitative real-time PCR (qPCR) allows the straightforward collection and storage of samples, making it possible to measure many samples at the same time. This technique facilitates the quantification of the number of bacteria within a shorter time than the culture method. In the present study, the total number of bacteria measured by qPCR was found to be significantly decreased (p<0.05) in stimulated whole saliva collected from 5 volunteers by chewing paraffin after tooth cleaning. These findings were in agreement with the decreases shown by Greene's Debris Index and O'Leary's PCR values. There was a significant correlation (r=0.55, p<0.01) between the salivary bacterial counts measured by qPCR from 81 subjects before and after a 4-month interval. These findings suggest that it is possible to measure the total number of bacteria in saliva using qPCR. This technique is convenient and is suggested to be applicable for assessing the oral hygiene status in the future. (Keyword) *Polymerase Chain Reaction (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679981008896 (CiNii: 1390282679981008896)
30.	Masami Yoshioka, 裕美藤井, 廣瀬薫, Harumi Sakamoto, Yuka Sogawa, Naoko Matsumoto, Yumi Hoshimo, Makoto Fukui, Masaaki Yokoyama and Daisuke Hinode : 急性期病院の脳神経疾患患者に対する口腔ケアニーズの分析, Journal of Dental Health, Vol.58, No.5, 490-497, 2008. (Summary) The purpose of the present study was to identify factors related to oral health care among inpatients with neurological disorders. For each of the 143 inpatients included in our study, the oral as well as general health (level of consciousness, feeding style, etc.) conditions were investigated using an assessment sheet at their first visit. The study revealed that 80% of the hospitalized patients showed "dysfunction of oral periphery muscle and/or tongue movement", 60% of them presented "dry mouth" and/or a "reduced level of consciousness", and 25% exhibited "constant open mouth with no intention". By logistic regression analysis of the data, it was strongly suggested that "severe debris accumulation" could be attributed to "dry mouth". Furthermore, "dry mouth" was found to be significantly correlated with several features, including "constant open mouth", "impaired mouth rinse", "dysfunction of oral periphery muscle and/or tongue movement", and "reduced level of consciousness", which are conditions often observed in patients with neurological disorders. These results suggest that inpatients with both a "reduced level of consciousness" and "constant open mouth" should receive professional oral care in order to prevent "dry mouth", and undergo a careful follow-up to promote the maintenance of good oral hygiene and functions. (Keyword) 専門的口腔ケア / 脳神経疾患 / 口腔乾燥 / 口腔衛生状態 / 急性期 / Professional oral care / Neurological disorders / Dry mouth / Oral hygiene condition / Acute phase (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205004141952 (CiNii: 1390001205004141952)
31.	Makoto Fukui, Masami Yoshioka, Kazuhito Satomura, Hiroaki Nakanishi and Masaru Nagayama : Specific-wavelength Visible Light Irradiation Inhibits the Growth of Porphyromonas gingivalis., Journal of Periodontal Research, Vol.43, No.2, 174-178, 2008. (Summary) The effects of laser irradiation on Porphyromonas gingivalis have been reported, but the results are still controversial regarding the efficiency because of the differences of the light sources and irradiation conditions. The aim of this study was to determine the wavelength and irradiation conditions under which the most effective inhibitory effect on P. gingivalis growth was seen without any photosensitizers. Using an Okazaki large spectrograph, monochromatic light spectra ranging from 400 to 700 nm were evaluated to determine which spectra effectively inhibited bacterial growth. Moreover, using a monochromatic 405-nm irradiating device, the effects of various irradiating conditions on P. gingivalis growth were examined. Growth of bacteria irradiated at 400 nm and 410 nm was significantly suppressed compared with a nonirradiated control, whereas wavelengths of 430 nm and longer produced no significant inhibition. A constant energy density of 15 J/cm2 was found to be enough to show an inhibitory effect. Significant inhibition of bacterial growth was found after only 1 min at 50 mW/cm2 irradiation. These results indicate that P. gingivalis growth is specifically suppressed by 405-nm light irradiation, suggesting that visible blue light irradiation is a promising means for eradicating periodontopathogenic bacteria from periodontal lesions. (Keyword) Colony Count, Microbial / Light / Microbial Viability / Porphyromonas gingivalis / Spectrophotometry (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1600-0765.2007.01009.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18302619 ● Search Scopus @ Elsevier (PMID): 18302619 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1600-0765.2007.01009.x (DOI: 10.1111/j.1600-0765.2007.01009.x, PubMed: 18302619)
32.	Masaaki Yokoyama, Daisuke Hinode, Masami Yoshioka, Makoto Fukui, Shin-ichi Tanabe, Daniel Grenier and Hiro-O Ito : Relationship between Campylobacter rectus and periodontal status during pregnancy., Oral Microbiology and Immunology, Vol.23, No.1, 55-59, 2008. (Summary) In a previous study, we showed that the growth of Campylobacter rectus is stimulated by the presence of female sex hormones in the culture medium. In the present study, we examined the relationship between C. rectus levels in the saliva and the periodontal status of pregnant women. Unstimulated whole saliva was collected from 22 pregnant and 15 non-pregnant women. Periodontal pocket depth (PD) and bleeding on probing (BOP) were recorded. A quantitative real-time polymerase chain reaction was performed to determine the concentrations of suspected periodontopathogenic bacteria in the saliva samples. In addition, the concentration of estradiol in the saliva samples was measured by enzyme immunoassay. The average age, number of teeth, and total number of bacteria in the saliva of subjects in both groups were similar. The percentage of sites with a PD = 4 mm and the salivary estradiol concentrations were significantly higher in pregnant women than in non-pregnant women. In addition, the percentage of BOP sites and the C. rectus levels in the saliva of the pregnant women tended to be higher than in non-pregnant women, although these differences were not statistically significant. There were positive correlations between C. rectus levels and estradiol concentrations, and between C. rectus levels and the percentage of sites with PD = 4 mm in the pregnant women. These results indicate that C. rectus levels are higher in the oral flora of pregnant women and that this may be associated with increased salivary estradiol concentrations. This may contribute to periodontal disease progression during pregnancy. (Keyword) Actinobacillus actinomycetemcomitans / Adult / Age Factors / Campylobacter rectus / Colony Count, Microbial / Dentition / Estradiol / Estrogens / Female / Fusobacterium nucleatum / Gingival Hemorrhage / Humans / Periodontal Index / Periodontal Pocket / Porphyromonas gingivalis / Pregnancy / Pregnancy Complications / Prevotella intermedia / Saliva (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1399-302X.2007.00391.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18173799 ● Search Scopus @ Elsevier (PMID): 18173799 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1399-302X.2007.00391.x (DOI: 10.1111/j.1399-302X.2007.00391.x, PubMed: 18173799)
33.	Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, Shin-ichi Tanabe and Masami Yoshioka : Salivary immunoglobulin A directed to oral microbial GroEL in patients with periodontitis and their potential protective role., Oral Microbiology and Immunology, Vol.21, No.5, 289-295, 2006. (Summary) The aim of this study was to identify salivary immunoglobulin A (IgA) directed to oral microbial GroEL in patients with periodontitis and to demonstrate their potential protective role through a reduction of inflammatory cytokine production induced by microbial GroEL. Using five different proteins belonging to the heat-shock protein 60 family, Western immunoblot analysis of salivary IgA from 63 subjects revealed immunoreactivities with Campylobacter rectus GroEL and Porphyromonas gingivalis GroEL in subjects with periodontitis (P < 0.05) compared to control subjects. Using the BIACORE 1000 to measure the salivary IgA titers directed towards C. rectus GroEL, high resonance unit (RU) values were observed in the saliva samples from patients with periodontitis (P < 0.01). Furthermore, the number of teeth with deep pocket depth (>or=5 mm) showed a high correlation coefficient with the RU value (r = 0.50, P < 0.01). C. rectus GroEL possessed the ability to stimulate the production of interleukin-6 by gingival fibroblasts. Interestingly, salivary IgA antibody directed to C. rectus GroEL caused a partial inhibition of interleukin-6 production. This study showed a relationship between high levels of salivary IgA directed to GroEL and periodontal disease severity. Although additional investigations are required, salivary IgA to GroEL may have a protective role by reducing the inflammatory response induced by GroEL derived from periodontopathogenic bacteria. (Keyword) Adult / Antigen-Antibody Reactions / Antigens, Bacterial / Blotting, Western / Campylobacter rectus / Case-Control Studies / Chaperonin 60 / Female / Humans / Immunoglobulin A, Secretory / Interleukin-6 / Male / Middle Aged / Periodontitis / Saliva / Salivary Proteins and Peptides / Statistics, Nonparametric (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1399-302X.2006.00290.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16922927 ● Search Scopus @ Elsevier (PMID): 16922927 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1399-302X.2006.00290.x (DOI: 10.1111/j.1399-302X.2006.00290.x, PubMed: 16922927)
34.	Masami Yoshioka, Tomoaki Honna, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani, Nozomi Yokoyama, Kaname Masuda, Daisuke Hinode and Ryo Nakamura : The Effects of Supervised Fluoride Mouth Rinsing on Dental Caries Development : Analyses of Caries Development by Tooth Type and of the Relationship between Deciduous Tooth Caries and Permanent Tooth Caries, Journal of Dental Health, Vol.55, No.5, 552-558, 2005. (Summary) In 1993, a daily fluoride mouth rinsing program and biannual oral examination were started at the nursery school, elementary school and junior high school of the K District, Tokushima Prefecture. In this study, the longitudinal change of caries development in elementary school students was evaluated. Caries development by tooth type in schoolchildren of the 6th grade was evaluated, and furthermore, the relationship between deciduous tooth caries in 1st grade students and caries development in permanent teeth in 6th grade students was also elucidated. After starting the daily fluoride mouth rinsing program, caries development in the permanent teeth of the low grade children of the elementary school began to decrease first, followed by that of the high grade children, and then, the junior high school students. It was revealed that the strong suppression of caries development in the 1st molar was reflected in a decrease in total caries development in the 6th grade schoolchildren. In addition, a significant relationship between DMFT in the 6th grade schoolchildren and the number of deciduous tooth caries or the number of deciduous teeth in the 1st grade schoolchildren was detected. These results suggest that a fluoride mouth rinsing program before school age is effective for caries prevention in the 1st molar, but, in order to effectively prevent permanent tooth caries, a high risk strategy is needed for children with deciduous tooth caries. (Keyword) Supervised fluoride mouth rinsing / Caries prevention / Analysis by tooth type / The relationship of the deciduous teeth caries to the permanent teeth caries (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.55.5_552 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205003730816 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.55.5_552 (DOI: 10.5834/jdh.55.5_552, CiNii: 1390001205003730816)
35.	Masami Yoshioka, Nozomi Yokoyama, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani and Daisuke Hinode : 官能試験の結果および質問票による口臭患者の分析, Journal of Dental Health, Vol.55, No.2, 83-88, 2005. (Summary) The aim of this study is to analyze the characteristics of patients suffering from malodor using organoleptic rating and questionnaires. Patients who were examined for halitosis at the Clinic of Preventive Dentistry, Tokushima University Medical and Dental Hospital, were classified into 4 groups based on the results of organoleptic measurement using plastic air bag. Aa group; obvious malodor beyond a socially acceptable level is neither perceived by dentists nor the patient. Ab group; obvious malodor is not perceived by dentists, although the patient complains of its existence. Ba group; obvious malodor is perceived by dentists only. Bb group; obvious malodor is perceived by both dentists and the patient. The profile of the Cornell Medical Index (CMI) Health Questionnaire and the questionnaire about a general attitudes toward halitosis were analyzed in each category. Patients in Ab group, who are supposed to have psychosomatic halitosis, showed a stronger tendency toward neurosis. More patients in the Ab group responded in the questionnaire that "I'm always anxious about malodor", and that "I feel malodor stronger than before", than in the other groups. Furthermore, patients in Aa and Ab group seemed to be interested in oral hygiene since many patients in these groups habitually used inter-dental brushing instruments daily. These results suggest that the sell-evaluation of breath by patients might provide useful information about the psychological conditions of patients. (Keyword) 口臭 / 官能試験 / 質問票 / 心因性口臭症 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679980640640 (CiNii: 1390282679980640640)
36.	Masami Yoshioka, Grenier Daniel, Daisuke Hinode, Makoto Fukui and Mayrand Denis : Antigenic cross-reactivity and sequence homology between Actinobacillus actinomycetemcomitans GroEL protein and human fibronectin, Oral Microbiology and Immunology, Vol.19, No.2, 124-128, 2004. (Summary) The immunologic cross-reactivity between human fibronectin and Actinobacillus actinomycetemcomitans GroEL was examined. Analyses by SDS-PAGE/Western immunoblotting and ELISA showed that a polyclonal antibody directed against the purified GroEL protein of A. actinomycetemcomitans, but not against the Escherichia coli GroEL, cross-reacts with human fibronectin. No antigenic cross-reactivity was observed between anti-A. actinomycetemcomitans GroEL antibody and type IV collagen, another important constituent of the basement membrane. A comparative analysis of the amino acid sequences of A. actinomycetemcomitans GroEL and human fibronectin revealed eight instances of four-amino acid sequence homology between the two proteins. Six of these tetrapeptide sequences were also shared with E. coli GroEL, suggesting that the remaining two tetrapeptides, GQLI (Glycine-Glutamine-Leucine-Isoleucine) and TGLE (Threonine-Glycine-Leucine-Glutamic acid), may be associated with the epitope that the anti-A. actinomycetemcomitans GroEL antibody specifically recognizes. Reactivity between TGLE, but not GQLI, with anti-A. actinomycetemcomitans GroEL antibody was confirmed by a biospecific interaction analysis using a biosensor technology. Although additional investigations are required, the observed phenomenon may lead to an autoimmune response and thus contribute to tissue destruction during periodontitis. (Keyword) Actinobacillus actinomycetemcomitans / fibronectin / GroEL / heat shock protein / periodontitis (Link to Publication Site) ● Publication site (DOI): 10.1111/j.0902-0055.2003.00125.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14871354 ● Search Scopus @ Elsevier (PMID): 14871354 ● Search Scopus @ Elsevier (DOI): 10.1111/j.0902-0055.2003.00125.x (DOI: 10.1111/j.0902-0055.2003.00125.x, PubMed: 14871354)
37.	Daisuke Hinode, Makoto Fukui, Nozomi Yokoyama, Masaaki Yokoyama, Masami Yoshioka and Ryo Nakamura : Relationship between tongue coating and secretory-immunoglobulin A level in saliva obtained from patients complaining of oral malodor, Journal of Clinical Periodontology, Vol.30, No.12, 1017-1023, 2003. (Summary) The aim of this study was to confirm the relationships between oral malodor and periodontal condition, oral malodor and tongue coating, and to investigate the secretory-immunoglobulin A (S-IgA) level in saliva in relation to the accumulation of tongue coating. Fifty-four patients complaining of oral malodor were included in the study. Their periodontal conditions, tongue coating status and salivary characteristics (flow rate, protein and S-IgA concentrations) were assessed in addition to the level of volatile sulfur compounds (VSC) in oral cavity. The patients were divided into three groups according to their tongue coating level. There are significant relationships between oral malodor and specific periodontal parameters used. The degree of tongue coating was also significantly correlated with the amount of H2S, CH3SH and the total amount of VSC determined. The concentration of S-IgA in the group identified as slight tongue coating was significantly higher than in the moderate or the severe group. By Western immunoblotting analysis, a high level of S-IgA specific to Streptococcus species was recognized in all groups, whereas the reactivity of Porphyromonas gingivalis and Fusobacterium nucleatum with S-IgA was very weak in both the slight and the moderate groups. Data herein indicate that tongue coating is closely related to oral malodor. Furthermore, S-IgA in saliva may influence the accumulation of tongue coating, and S-IgA antibodies directed to Streptococcus species may play a role in protective immunity against the initial colonization of tongue plaque. (Keyword) oral malodor / saliva / secretory-IgA / tongue coating (Link to Publication Site) ● Publication site (DOI): 10.1046/j.0303-6979.2003.00407.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15002886 ● Search Scopus @ Elsevier (PMID): 15002886 ● Search Scopus @ Elsevier (DOI): 10.1046/j.0303-6979.2003.00407.x (DOI: 10.1046/j.0303-6979.2003.00407.x, PubMed: 15002886)
38.	Hideki Nagata, Miki Ojima, Satoshi Shizukuishi, Akane Takemura, Daisuke Hinode, Makoto Fukui and Ryo Nakamura : Effect of vitamin C and vitamin E supplement on periodontal disease in smokers, Journal of Dental Health, Vol.53, No.5, 544-553, 2003. (Summary) Smoking habit has been reported as a risk factor for periodontal disease and low vitamin C intake has been associated with periodontal status. In this randomized controlled trial, we investigated the efficacy of dietary supplementation with antioxidative vitamins, vitamins C and E, on suppression of the progression of periodontal disease in smokers. A total of 65 patients who were current smokers were randomly assigned to one of the following groups : 1) VC (1,000 mg/day) ; 2) VE (135 mg/day) ; 3) combination of VC and VE ; 4) placebo. Plaque index (PI), clinical attachment level (CAL), pocket depth (PD) and cross-linked carboxyterminal telopeptide of type I collagen (I CTP) from gingival crevicular fluid (GCF) as a biomarker of periodontal disease, were measured at baseline, 12 and 24 weeks following the start of supplementation. CAL and PD in VC, VE and the combination groups showed significant improvements during this trial comparing with the placebo group (p<0.05). Furthermore, in the combination group, the rate of GCF samples in which I CTP was decreased or maintained was significantly greater than that in the placebo group at 24 weeks (p<0.05). On the other hand, VC levels in blood samples from VC and the combination groups (p<0.01) and VE levels from VE and the combination groups significantly rose from each level at baseline (p<0.05). These results suggest that supplements of VC and VE may maintain the periodontal health status in smokers by controlling oxidative status and other mechanisms. (Keyword) Risk factor for periodontal disease / Smoking habit / Vitamin C / Vitamin E / Randomized controlled trial (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205004003072 (CiNii: 1390001205004003072)
39.	Shin-ichi Tanabe, Daisuke Hinode, Masaaki Yokoyama, Makoto Fukui, Ryo Nakamura, Masami Yoshioka, Daniel Grenier and Denis Mayrand : Helicobacter pylori and Campylobacter rectus share a common antigen, Oral Microbiology and Immunology, Vol.18, No.2, 79-87, 2003. (Link to Publication Site) ● Publication site (DOI): 10.1034/j.1399-302X.2003.00049.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12654095 ● Search Scopus @ Elsevier (PMID): 12654095 ● Search Scopus @ Elsevier (DOI): 10.1034/j.1399-302X.2003.00049.x (DOI: 10.1034/j.1399-302X.2003.00049.x, PubMed: 12654095)

Academic Paper (Unrefereed Paper):

1.	Makoto Fukui : Relationship between Halitosis and Biologically Active Substances in Saliva, Shikoku Dental Research, Vol.21, No.1, 129-141, 2008.

Review, Commentary:

1.	Makoto Fukui : Specific-wavelength Visible Light Irradiation Inhibits Bacterial Growth of Porphyromonas gingivalis, Shikoku Dental Research, Vol.23, No.2, 91-96, Jan. 2011. (Tokushima University Institutional Repository) ● Metadata: 109803 (Tokushima University Institutional Repository: 109803)
2.	Masami Yoshioka, 裕美藤井, 薫廣瀬, Harumi Sakamoto, Yuka Sogawa, Akiko Satoh, Makoto Fukui, Masaaki Yokoyama and Daisuke Hinode : Professional Oral Care of Inpatients by Members of the Nutrition Support Team in Tokushima University Medical and Dental Hospital, Journal of Dental Health, Vol.56, No.3, 309-317, Jul. 2006. (Summary) As members of the Nutrition Support Team (NST) at Tokushima University Medical and Dental Hospital, we have worked on professional oral care (POC) with our inpatients. Also, we started bedside POC with inpatients after studying their health and nutrient intake. This led us to have a closer working relation with ward staff and improve the oral care provided by nurses during their routine work. The results of the first oral examination of 43 inpatients we have included so far showed that the percentage of oral problems such as tongue coating, debris, dental plaque, calculus, expectoration, dry mouth, and bad breath were considerably high. Many of these oral conditions were thought to be related to the patients' physical conditions. After POC, however, improvements in patients' oral conditions were noted in more than 50 percent of the cases. Consequently, it can be said that the POC provided by the NST has not only improved the oral hygiene condition of patients but also nurtured closer working relations among departmental staff in the hospital. (Keyword) Nutrition support team / Professional oral care / Cooperation with staff (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205002281088 (CiNii: 1390001205002281088)
3.	Masami Yoshioka, Masaaki Yokoyama, Tomoaki Honna, Makoto Fukui, Nozomi Yokoyama, Shin-ichi Tanabe, Kanako Tamatani, Harumi Sakamoto, Akiko Satoh, Ryo Nakamura and Daisuke Hinode : 予防歯科臨床における定期的口腔健康管理, Shikoku Dental Research, Vol.16, No.2, 401-409, Jan. 2004. (Keyword) 定期的口腔健康管理 / 支援的歯周治療 / 予防歯科臨床 / 歯周疾患指導管理票 / 動機付け

Proceeding of International Conference:

1.	R Prihastuti, Daisuke Hinode, Makoto Fukui, Omar Maningo Rodis and Yoshizo Matsuka : Enhancement of oral hygiene behavior and oral health outcomes following the theory-based educational intervention, International Symposium on Dental Hygiene 2024, Seoul, Jul. 2024.
2.	R Prihastuti, Daisuke Hinode, Makoto Fukui, Omar Maningo Rodis and Yoshizo Matsuka : Two different oral hygiene measurements following a theory-based educational intervention, Japanese Association for Dental Research, Sendai, Nov. 2023.
3.	Hideyuki Takano, Makoto Fukui, Natsumi Fujiwara, Yukihiro Momota and Keiko Aota : The usefulness of non-face-to-face clinical practice using smart glasses in dental hygiene student education, The 3rd annual meeting of the International Society of Oral Care, Apr. 2023.
4.	Keiko Aota, Tsuruta Mai, Okamoto Tomomi, Masugi Sachie, Shinji Ono, Kanakawa Hiroko, Hideyuki Takano, Makoto Fukui and Daisuke Hinode : Factors associated with the development of oral mucositis in pharyngeal cancer patients receiving chemoradiotherapy, The 3rd Annual Meeting of the International Society of Oral Care, Apr. 2023.
5.	Yuka Sogawa, Makoto Fukui, Shingen Nakamura, Kimiko Sogabe, Ryohei Sumitani, Masami Yoshioka, Masahiro Abe and Daisuke Hinode : Risk factors for chemotherapy-induced febrile neutropenia in hematological cancer patients, 106th Annual Meeting of American Academy of Periodontology, Honolulu, Nov. 2020. (Summary) 1
6.	Makoto Fukui, Tokiko Doi, Harumi Sakamoto, Masami Yoshioka, 岡本好史, Shuji Mori, Miwa Matsuyama, Fumiaki Kawano and Daisuke Hinode : Long-term smoking affects the oral health status of latter-stage elderly males and increases the cost of dental treatment, 第15回国際タバコ病予防学会学術総会, Tokyo, Oct. 2019. (Keyword) smoking / 口腔健康状態 / 歯科医療費 / 後期高齢者
7.	Harumi Sakamoto, Makoto Fukui, Daisuke Hinode and Masami Yoshioka : The usefulness of prenatal dental health check-ups., 21st International symposium on Dental Hygiene (August 13-16, 2019, Brisben, Australia, Aug. 2019.
8.	Makoto Fukui, Kaname Miki, Kitamura Masayasu, Hayashida Hideaki, Kawasaki Koji, Rita Cristina Orihuela Campos, Naofumi Tamaki, Maeda Takahiro, Saito Toshiyuki and Hiro-O Ito : Porphyromonas gingivalis infection may affect anti-atheroschlerotic antibody to phosphorylcholine., The 12th International Conference of Asia Academy of Preventive Dentistry, May 2016.
9.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Balance is the key: resveratrol revert oxidative stress conditions in gingival fibroblasts, 第93回IADR, Mar. 2015.
10.	Naofumi Tamaki, Makoto Fukui, Hiro-O Ito and Kokeguchi Susumu : Salivary Antioxidant Activity, Cytokines and Periodontitis: The Nagasaki Island Study, International Association for Dental Research-Asia Pacific Region(IADR-APR), Bangkok, Aug. 2013.
11.	Makoto Fukui, Kaname Miki, Naofumi Tamaki and Hiro-O Ito : Relationship between atherosclerosis and anti-phosphorylcholine antibodies in saliva and plasma, ICAAPD, ウランバートル, Sep. 2012.
12.	Naofumi Tamaki, Makoto Fukui and Hiro-O Ito : Levels of Serum Markers of Oxidative Stress and Antibodies against Periodontal Pathogens in Community-dwelling Adults with and without Periodontitis: Goto Study, International Conference on Porphyromonas gingivalis and Related Bacterial Species, Nagasaki, Aug. 2012.
13.	Makoto Fukui, M. Mani, K. Uno, Kosuke Kataoka and Hiro-O Ito : Cytokine profile in human saliva and its relationship with that in blood., 9th International Conference Asian Academy of Preventive Dentistry, Kuala Lumpur, Malaysia, Nov. 2010.
14.	Kosuke Kataoka, Ke. Fujihashi, R. Kobayashi, S. R. Gilbert, S. Sekine, Makoto Fukui, Y. Fukuyama, S. Kawabata, Hiro-O Ito and Ko. Fujihashi : Nasal Cholera Toxin Activated Mucosal Densritic Cells, but not CD4+ Cells Elicits TI-IgA Class Switching Recombination by B-1 B Cells., 14th International Congress of Immunology, Aug. 2010.
15.	T. Baatarjav, Kosuke Kataoka, Makoto Fukui, A. S. Mulyatno, K. Fujihashi and Hiro-O Ito : Nasal Vaccination with Phosphorylcholine plus Flt3 Ligand Gene as a Mucosal Adjuvant Inhibits Streptococcus pneumoniae Colonization., 14th International Congress of Immunology, Kobe, Aug. 2010.
16.	Daisuke Hinode, Masaaki Yokoyama, Makoto Fukui, Nozomi Yokoyama, Kanako Tamatani and Masami Yoshioka : The Effect of Tongue Cleaning on Oral Malodor, 86th General Session & Exhibition of the IADR/ 32nd Annual Meeting of the CADR, Toronto, Jul. 2008.
17.	Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, Masami Yoshioka and Hiro-O Ito : Salivary Stress Makers in Patients with Complaint of Halitosis., 7th Congress of Asian Academy of Preventive Dentistry, Okayama, Nov. 2006.
18.	Makoto Fukui, Masami Yoshioka, Kazuhito Satomura, Hiroaki Nakanishi and Masaru Nagayama : Specific Visible Light Irradiation Inhibits the Growth of Porphyromonas gingivalis., 84th General Session & Exhibition of the International Association for Dental Research, Brisbane, Jun. 2006.
19.	Daisuke Hinode, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe and Masami Yoshioka : Role of Salivary IgA directed to GroEL in Periodontitis Patients., 84th General Session & Exhibition of the International Association for Dental Research, Brisbane, Jun. 2006.
20.	H Nagata, M Ojima, Daisuke Hinode, Makoto Fukui, A Takemura, S.G Grossi, S Shizukuishi and R Nakamura : Vitamin C and E supplements supress periodontal disease in smokers, Annual Meeting of American Academy of Periodontology, San Francisco, Sep. 2003.
21.	Daisuke Hinode, Makoto Fukui and R Nakamura : The relationship between tongue coating and Secretory- IgA level in saliva from patients complaining of oral malodor, China-Japan Medical Conference 2002, Beijing, Nov. 2002.
22.	Makoto Fukui, Nozomi Matsuoka, Tuyoshi Akagi, Shin-ichi Tanabe, Kanako Tamatani, Masaaki Yokoyama, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : The relationship between tongue plaque and secretary-IgA in saliva from patients with breath odor, Fifth International Conference on Breath Odor Research, Tokyo, Jul. 2001.
23.	Shin-ichi Tanabe, Masaaki Yokoyama, Makoto Fukui, Daisuke Hinode and Ryo Nakamura : Immunological relationship between periodontopathogenic bacteria and Helicobacter pylori, Journal of Dental Research, Vol.80, No.Special Issue, 679, Chiba, Mar. 2001.

Proceeding of Domestic Conference:

1.	Masami Yoshioka, Hiromi Nakae, Makoto Fukui, Shizuko Yanagisawa, Yuka Sogawa, Harumi Sakamoto and Daisuke Hinode : 歯磨き習慣とリンクさせた動画視聴の教育的効果の検討, 第72回日本口腔衛生学会総会, May 2023.
2.	鶴田真生, 清野方子, 田倉幸子, 福島みどり, 岡本知美, 幸江真杉, Shinji Ono, 金川裕子, Hideyuki Takano, Makoto Fukui, Daisuke Hinode and Keiko Aota : 咽頭がん化学放射線療法患者の口腔粘膜炎発症に影響を与える因子に関する研究, 第20回日本口腔ケア学会総会・学術集会, Apr. 2023.
3.	Keiko Aota, 鶴田真生, 岡本知美, 幸江真杉, Shinji Ono, 金川裕子, Hideyuki Takano, Makoto Fukui and Daisuke Hinode : Factors associated with the development of oral mucositis in pharyngeal cancer patients receiving chemoradiotherapy, 第20回日本口腔ケア学会総会・学術集会, Apr. 2023.
4.	篠原千尋, Masami Yoshioka, 中江弘美, 十川悠香, Harumi Sakamoto, Makoto Fukui, Daisuke Hinode and 中野雅徳 : 経口摂取要介護高齢者の発熱に影響する因子の検討, 令和4年度四国公衆衛生研究発表会, Feb. 2023.
5.	Masami Yoshioka, 中江弘美, Makoto Fukui, 篠原千尋, 十川悠香, Harumi Sakamoto and Daisuke Hinode : コモンリスクファクターアプローチのツールとしての口腔保健教育動画の開発, 第33回近畿・中国・四国口腔衛生学会総会, Oct. 2022.
6.	Tokiko Doi, Makoto Fukui, Harumi Sakamoto, 下村学, 岡本好史, 松本侯, Masami Yoshioka and Daisuke Hinode : 後期高齢者のオーラルフレイル予防を目的とした健口体操の効果, 第33回近畿・中国・四国口腔衛生学会総会, Oct. 2022.
7.	AMOH Saki, Makoto Fukui, 福島みどり, 佐原久美子, 武川香織, 幸江真杉, 十川悠香, Kanako Tamatani, Masami Yoshioka and Daisuke Hinode : 悪性リンパ腫患者の好中球減少に伴う発熱に関連する口腔環境因子の解明, 第33回近畿・中国・四国口腔衛生学会総会, Oct. 2022.
8.	SONE Ichika, Tokiko Doi, Makoto Fukui, 下村学, 岡本好史, 松本侯, Miwa Matsuyama, Masami Yoshioka and Daisuke Hinode : 高齢者の口腔環境と肺炎発症との関連性, 第33回近畿・中国・四国口腔衛生学会総会, Oct. 2022.
9.	Harumi Sakamoto, Makoto Fukui, Tokiko Doi, KUBO Eri, Masami Yoshioka and Daisuke Hinode : 3歳児のう蝕発症に関与する1歳6か月児健診時点での要因の分析, 日本歯科衛生学会第17回学術大会, Sep. 2022.
10.	Izumi Sasaki, Makoto Fukui, Harumi Sakamoto, Kanako Tamatani and Daisuke Hinode : 口臭症患者に認められる揮発性硫黄化合物と口腔環境との関連性, 日本口腔衛生学会, May 2022.
11.	Eri Kubo, Harumi Sakamoto, Makoto Fukui and Daisuke Hinode : 妊婦の口腔環境改善に関する課題の検討, 日本口腔衛生学会, May 2022.
12.	Masami Yoshioka, 川島友一郎, Makoto Fukui, Shizuko Yanagisawa, Hiromi Nakae, Yuka Sogawa and Daisuke Hinode : 糖尿病外来患者の血糖および体重コントロールに関連する因子の検討―2年間のコホート研究より―, 第70回日本口腔衛生学会総会, May 2022.
13.	福島みどり, 幸江真杉, 武川香織, Saki Amoh, Kanako Tamatani, Makoto Fukui, 金川裕子 and Daisuke Hinode : 大学病院での歯科衛生士業務の効率化に関する調査(第2報), 第32回近畿・中国・四国口腔衛生学会総会, Oct. 2021.
14.	Kumiko Sahara, Makoto Fukui, Harumi Sakamoto, Tokiko Doi, Masami Yoshioka, 岡本好史, 松本侯, Miwa Matsuyama, Fumiaki Kawano and Daisuke Hinode : 後期高齢者の口腔状態と要介護認定または死亡発生との関連性, 第32回近畿・中国・四国口腔衛生学会総会, Oct. 2021.
15.	Masami Yoshioka, 川島友一郎, Makoto Fukui, Shizuko Yanagisawa, Hiromi Nakae, Yuka Sogawa and Daisuke Hinode : 糖尿病外来患者の口腔健康状態/歯科保健行動と高LDLコレステロール血症との関連性, 日本口腔衛生学会特別大会(第24回日本歯科医学会学術大会), Sep. 2021.
16.	渡辺美南, Harumi Sakamoto, Makoto Fukui, Masami Yoshioka and Daisuke Hinode : 母親の喫煙習慣と歯科保健行動および子どもの口腔状態との関連性, 第15回日本禁煙科学会学術総会, Dec. 2020.
17.	Makoto Fukui, 佐原久美子, Tokiko Doi, Harumi Sakamoto, Masami Yoshioka, Miwa Matsuyama, Fumiaki Kawano, 岡本好史, Shuji Mori and Daisuke Hinode : オーラルフレイル関連項目と医療費の関連性, 第31回近畿・中国・四国口腔衛生学会総会, Oct. 2020. (Keyword) diabetes mellitus / 口腔状態 / 医療費 / 後期高齢者
18.	Masami Yoshioka, 川島友一郎, 南明香, Makoto Fukui, Shizuko Yanagisawa and Daisuke Hinode : 糖尿病コントロールを表す臨床指標と歯科保健行動との関連性, 第69回日本口腔衛生学会総会, Apr. 2020.
19.	Harumi Sakamoto, Minami Watanabe, Daisuke Hinode, Makoto Fukui, Masami Yoshioka, 藤川貴代, 喜來浩子 and 四宮宣尚 : 妊産婦の喫煙習慣と歯科保健行動との関連性, 令和元年度四国公衆衛生研究発表会(2020年2月14日，阿波銀ホール・徳島市), Feb. 2020.
20.	福島みどり, 田口侑子, 武川香織, 幸江真杉, Kanako Tamatani, Makoto Fukui, Masami Yoshioka, 金川裕子 and Daisuke Hinode : 大学病院での歯科衛生士業務の効率化に関する調査(第1報), 第30回近畿・中国・四国口腔衛生学会総会, Sep. 2019.
21.	Kumiko Sahara, Tokiko Doi, Makoto Fukui, Harumi Sakamoto, Masami Yoshioka, 岡本好史, Shuji Mori, Miwa Matsuyama, Fumiaki Kawano and Daisuke Hinode : 後期高齢者における糖尿病と口腔状態および医療費の関連性, 第30回近畿・中国・四国口腔衛生学会総会, Sep. 2019. (Keyword) diabetes mellitus / 口腔状態 / 医療費 / 後期高齢者
22.	Shibyoh Oh, Akari Watanabe, Miwa Matsuyama, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : ATP測定法による口腔内細菌数の評価, 第30回近畿・中国・四国口腔衛生学会総会, Sep. 2019. (Keyword) ATP測定 / 口腔内細菌
23.	渡辺美南, Harumi Sakamoto, Makoto Fukui, Masami Yoshioka and Daisuke Hinode : 妊産婦の喫煙習慣と歯科保健行動及び子どもの口腔状態との関連性, 第14回日本禁煙科学会学術総会, Sep. 2019.
24.	Yuka Sogawa, Masami Yoshioka, 南明香, Makoto Fukui, Daisuke Hinode, Shingen Nakamura and Masahiro Abe : 自家末梢血幹細胞移植患者の口腔ケアによる口腔粘膜炎障害の低減効果, 第68回日本口腔衛生学会総会, May 2019.
25.	Harumi Sakamoto, Minami Watanabe, Daisuke Hinode, Makoto Fukui, Masami Yoshioka, 藤川貴代, 喜來浩子 and 四宮宣尚 : 妊産婦の喫煙習慣と歯科保健行動との関連性, 平成30年度四国公衆衛生研究発表会, Feb. 2019.
26.	河野りか, Tokiko Doi, Makoto Fukui, 松村佑季, Harumi Sakamoto, Kanako Tamatani, Masami Yoshioka, 福島襄, 阿部昭人 and Daisuke Hinode : 児童の肥満と口腔状態および生活習慣の関連性, 第29回近畿・中国・四国口腔衛生学会, Sep. 2018.
27.	Kaname Miki, Makoto Fukui, CHEN SHU, Naofumi Tamaki and Hiro-O Ito : 天然ハーブ・キャッツクロー抽出物の歯周病原菌に対する抗菌効果, 第29回近畿中国四国口腔衛生学会, Sep. 2018.
28.	Hideyuki Takano, 宮本由貴, Makoto Fukui, Naofumi Tamaki, Hiro-O Ito and Masayuki Azuma : 当院栄養サポートチームにおける歯科医師連携の現況, 四国歯学会第53回例会, Jul. 2018.
29.	Hideyuki Takano, Shinji Ono, Makoto Fukui, Naofumi Tamaki, Masami Yoshioka, Yukihiro Momota, Hiro-O Ito and Masayuki Azuma : 徳島大学病院NSTにおける歯科医師連携の現況と課題, 第15回日本口腔ケア学会総会・学術大会, Apr. 2018.
30.	Makoto Fukui, Naofumi Tamaki, 福田功 and Hiro-O Ito : 多項目唾液バイオマーカー検査による歯周組織炎症の評価, 日本歯周病学会60周年記念京都大会, Dec. 2017.
31.	Makoto Fukui, CHEN SHU, Kaname Miki, Naofumi Tamaki, 福田功 and Hiro-O Ito : 歯肉炎症の評価における3種の唾液潜血検査の有用性の検討第28回近畿・中国・四国口腔衛生学会総会 2017年10月1日広島大学歯学部(広島市), 第28回近畿・中国・四国口腔衛生学会総会, Oct. 2017.
32.	Makoto Fukui, CHEN SHU, Kaname Miki, Naofumi Tamaki, 福田功 and Naofumi Tamaki : 歯肉炎症の評価における3種の唾液潜血検査の有用性の検討, 第28回近畿・中国・四国口腔衛生学会・総会, Oct. 2017.
33.	Naofumi Tamaki, Rita Cristina Orihuela Campos, CHEN SHU, Makoto Fukui and Hiro-O Ito : 実験的口腔粘膜炎モデルにおけるレスベラトロールの効果の検討, 第66回日本口腔衛生学会・総会, May 2017.
34.	Fumiya Narasaki, Shiori Matsuoka, Naofumi Tamaki, Makoto Fukui and Hiro-O Ito : フッ化物洗口の口腔環境に及ぼす効果, 四国歯学会第50回例会, Mar. 2017.
35.	松尾亮水野明彦鈴木雅春鈴木章一郎柳田國雄, Naofumi Tamaki, Makoto Fukui and Hiro-O Ito : 糖尿病外来患者におおけるHbA1c値の2年間の経過とかかりつけ歯科医の関係, 第51回日本成人病(生活習慣病)学会, Jan. 2017.
36.	Makoto Fukui, 早渕純子, 西尾よしみ, 竹内早苗, 小百合横山, Yumiko Izaki, Hiro-O Ito and Kenichi Maeda : 歯科検診10年の取り組み, Oct. 2016.
37.	Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito : 唾液潜血検査の判定を妨害する因子の検索, 第27回近畿・中国・四国口腔衛生学会・総会, Oct. 2016.
38.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui and Hiro-O Ito : Polyphenols reduce collateral damage in HGFs induced by oxidative stress, 44th Annual Meeting of the Japanese Society for Immunology, Nov. 2015.
39.	Makoto Fukui, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito : Influence of infection with Porphyromonas gingivalis on relationship between atherosclerosis and antiphosphorylcholine antibody, 44th Annual Meeting of the Japanese Society for Immunology, Nov. 2015.
40.	Makoto Fukui, Kaname Miki, K Kitamura, H Hayashida, K Kawasaki, Rita Cristina Orihuela Campos, Naofumi Tamaki, T Maeda, T Saito and Hiro-O Ito : Atherosclerosis-preventive activity of anti-phosphorylcholine antibody may be interfered by infection with Porphyromonas gingivalis : The Nagasaki Islands study, 63rd Annual Meeting of the Japanese Association of Dental Research, Oct. 2015.
41.	岡田寿郎, 福井隆夫, 藤村英二, 大月陽子, 西雅子, 豊島健治, Makoto Fukui, Naofumi Tamaki, Hiro-O Ito and 奥弘文 : 日本歯科医師会の``生活支援プログラム''による健診事業の参加者の満足度および行動変容への効果, 第26回近畿・中国・四国口腔衛生学会総会, Sep. 2015.
42.	鈴木雅博, 水野昭彦, 松尾亮, Naofumi Tamaki, Makoto Fukui and Hiro-O Ito : 糖尿病教育入院患者における歯肉溝液中の炎症関連バイオマーカーの経時的変化, 第26回近畿・中国・四国口腔衛生学会総会, Sep. 2015.
43.	橋本智惠子, 西窪美波, Naofumi Tamaki, Makoto Fukui and Hiro-O Ito : キシリトールガム咀嚼による唾液分泌能と唾液細菌叢の変化, 第45回四国歯学会, Jun. 2015.
44.	水野昭彦, 松尾亮, 鈴木雅博, Naofumi Tamaki, Makoto Fukui, Kaname Miki, 松瀬亮一 and Hiro-O Ito : 市民検診と糖尿病患者データにおける歯肉溝浸出液バイオマーカーの比較検討, 第64回口腔衛生学会総会, May 2015.
45.	Naofumi Tamaki, Rita Cristina Orihuela Campos, Makoto Fukui, Kaname Miki and Hiro-O Ito : 水素水の抗酸化・抗炎症作用の検討, 第64回口腔衛生学会総会, May 2015.
46.	Makoto Fukui, 岡田寿郎, Kaname Miki, Naofumi Tamaki and Hiro-O Ito : ``標準的な成人歯科健診プログラム・保健指導マニュアル''に基づいた歯科保健事業の効果について, 第64回口腔衛生学会総会, May 2015.
47.	松尾亮, 水野昭彦, 鈴木雅博, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : 歯肉溝浸出液バイオマーカーと血液データの比較検討, 第49回日本成人病(生活習慣病)学会, Jan. 2015.
48.	Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito : Levels of various cytokines in human saliva from generally healthy individuals., 62nd Annual Meeting of the Japanese Association for Dental Research, Dec. 2014.
49.	福井隆夫, 小林弘茂, 渋谷敦人, Jurou Okada, 豊嶋健, Makoto Fukui, Naofumi Tamaki, Hiro-O Ito and 弘文奥 : 日歯生活歯援プログラムに基づく平成25年度成人歯科健診事業実施報告, 第25回近畿・中国・四国口腔衛生学会総会, Oct. 2014.
50.	Kenjiroh Takao, Mamiko Nii, Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito : 歯肉炎症の客観的・定量的診断を目指した市販免疫クロマトグラフィー唾液潜血テストの改良, 第25回近畿・中国・四国口腔衛生学会総会, Oct. 2014.
51.	水野昭彦, 松尾亮, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : 歯肉溝浸出液バイオマーカーと血液データの比較, 第25回近畿・中国・四国口腔衛生学会総会, Oct. 2014.
52.	Naofumi Tamaki, 水野昭彦, 松尾亮, 正木文浩, 中川徹, 鈴木雅博, 青木良平, 松瀬亮一, Makoto Fukui and Hiro-O Ito : 歯肉溝浸出液中バイオマーカーと腎機能・糖尿病指標との関連, 第7回日本口腔検査学会総会・学術大会, Sep. 2014.
53.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Effects of three different antioxidants on human gingival fibroblasts exposed to oxidative stress, 2014 Tokushima Bioscience retreat, Sep. 2014.
54.	Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito : 健常者における唾液中サイトカインプロファイルの解析, 第63回口腔衛生学会総会, May 2014.
55.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Effects of three antioxidant compounds on human gingival fibroblasts under oxidative stress, 第63回口腔衛生学会総会, May 2014.
56.	Naofumi Tamaki, Rita Cristina Orihuela Campos, Makoto Fukui and Hiro-O Ito : 口蓋創傷治癒モデルにおける水素水摂取の効果, 第4回分子状水素医学シンポジウム, Feb. 2014.
57.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Effects of different antioxidants on human gingival fibroblasts under oxidative stress, 第5回心・血管クラスターミニリトリート, Jan. 2014.
58.	小林弘茂, 渋谷敦人, 福井隆夫, Jurou Okada, 豊嶋健治, Makoto Fukui, Naofumi Tamaki, Hiro-O Ito and 弘文奥 : 日歯プログラムに基づく成人歯科健診における唾液検査および質問紙調査と歯周状態の関連性について, 第24回近畿・中国・四国口腔衛生学会総会, Oct. 2013.
59.	Makoto Fukui, Kaname Miki, Naofumi Tamaki and Hiro-O Ito : 唾液中サイトカインと口腔健康状態の関連性, 第24回近畿・中国・四国口腔衛生学会総会, Oct. 2013.
60.	Makoto Fukui, Naofumi Tamaki and Hiro-O Ito : 唾液を用いた高齢者の口腔健康状態把握のための基盤的研究, 第56回秋季日本歯周病学会学術大会, Sep. 2013.
61.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Effects of different antioxidants on the biological properties of human gingival fibroblasts response toward ROS, Tokushima Bioscience retreat, Sep. 2013.
62.	Murasaki Miyagi, Mitsutaka Kimura, Shohei Inoue, Michiyasu Nakao, Shigeki Sano, Makoto Fukui and Hiro-O Ito : A Modified OPA Method for a Valid Measure of Oral Malodor, 第11回プロセス化学東四国フォーラムセミナー, Jun. 2013.
63.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Real time xCELLigence analysis of antioxidant agents on human gingival fibroblast cells viability, 第62回日本口腔衛生学会総会, May 2013.
64.	Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito : 健常者における唾液中サイトカイン分析, 第62回日本口腔衛生学会・総会, May 2013.
65.	Murasaki Miyagi, Mitsutaka Kimura, Shohei Inoue, Michiyasu Nakao, Shigeki Sano, Makoto Fukui and Hiro-O Ito : A Modified OPA Method for a Valid Measure of Oral Malodor, 日本薬学会第133年会, Mar. 2013.
66.	Makoto Fukui, Naofumi Tamaki, Kaname Miki and Hiro-O Ito : 動脈硬化リスク評価のための唾液・血液中の抗ホスホリルコリン抗体の測定, 心血管クラスターリトリート, Jan. 2013.
67.	SA Mulyatno, Naofumi Tamaki, Makoto Fukui and Hiro-O Ito : Mucosal adjuvanticity of bacterial lipopolysaccharide in compared with cholera toxin, Proceedings of the Japanese Society for Immunology, Dec. 2012.
68.	Jurou Okada, 小林宏茂, 福井隆夫, 渋谷敦人, 裕光武部, 豊嶋健治, Makoto Fukui, Hiro-O Ito and 弘文奥 : 平成22年度に香川県内で実施された成人歯科健診モデル事業実施報告, 第22回日本歯科医学会総会, Nov. 2012.
69.	Murasaki Miyagi, Mitsutaka Kimura, Shohei Inoue, Michiyasu Nakao, Shigeki Sano, Makoto Fukui and Hiro-O Ito : オルトフタルアルデヒド法を基盤とした新規メチルメルカプタン蛍光標識法, 第51回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2012.
70.	天羽崇, Daisuke Hinode, 平島美穂, Masami Yoshioka, Masaaki Yokoyama, Kanako Tamatani, Makoto Fukui, Hiro-O Ito and Kosuke Kataoka : 舌苔中の歯周病関連細菌と口臭との関連性, 第23回近畿中国四国口腔衛生学会総会, Oct. 2012.
71.	Makoto Fukui, Naofumi Tamaki and Hiro-O Ito : 成人歯科健診事業における唾液検査と歯周所見の一致性について, 第23回近畿中国四国口腔衛生学会総会, Oct. 2012.
72.	Makoto Fukui, Naofumi Tamaki and Hiro-O Ito : 平成23年度に香川県内で実施した「成人歯科健診モデル事業」における保健行動目標の達成状況について, 第23回近畿中国四国口腔衛生学会総会, Oct. 2012.
73.	Makoto Fukui, Kaname Miki, Naofumi Tamaki and Hiro-O Ito : 動脈硬化リスク評価のための唾液・血液中の抗ホスホリルコリン抗体の測定, 第5回日本口腔検査学会総会・学術大会, Aug. 2012.
74.	SA Mulyatno, Kosuke Kataoka, Makoto Fukui, Kaname Miki, RC Orihuela-Campos and Hiro-O Ito : Modulation of Mucosal Immune Response by Bacterial Lipopolysaccharide in Nasal Vaccination Model, 第61回日本口腔衛生学会・総会, May 2012.
75.	Makoto Fukui, SA Mulyatno, Masaki GOTO, Kaname Miki, RC Orihuela-Campos, Kosuke Kataoka, 林田秀明, 北村雅保, 川崎浩二, 関田孝晴, 中里未央, 前田隆浩, 齋藤俊行 and Hiro-O Ito : ヒト唾液中および血中の抗ホスホリルコリン抗体と動脈硬化リスクとの関連性-第二報-, 第61回日本口腔衛生学会・総会, May 2012.
76.	Makoto Fukui, Sapta Adisuka Mulyatno, バータルジャフツェルメグ, Masaki GOTO, Kosuke Kataoka, 林田秀明, 川崎浩二, 前田隆浩, 中里未央, 齋藤俊行 and Hiro-O Ito : ヒト唾液中および血中の抗ホスホリルコリン抗体と動脈硬化リスクとの関連性:五島研究, Oct. 2011.
77.	Sapta Adisuka Mulyatno, Kosuke Kataoka, 関根伸一, バータルジャブツェルメグ, Makoto Fukui, 金川裕子, Masaki GOTO and Hiro-O Ito : 経鼻粘膜アジュバントCpG ODNはマクロファージのTLR9発現と歯周病細菌抗原特異的Th1免疫応答を誘導する, Oct. 2011.
78.	渋谷敦人, 小林弘茂, 福井隆夫, Jurou Okada, 豊嶋健治, Makoto Fukui, Kosuke Kataoka, Hiro-O Ito and 奥弘文 : 平成22年度に香川県内で実施された成人歯科健診モデル事業実施報告, Oct. 2011.
79.	武川香織, 幸江真杉, Yuka Sogawa, Harumi Sakamoto, Makoto Fukui, Kosuke Kataoka, Masami Yoshioka and Daisuke Hinode : 妊婦歯科健康診査受診者の妊娠中の歯周状態と出産の状況について, 第22回近畿・中国・四国口腔衛生学会総会抄録集, 19, Oct. 2011.
80.	T. Baatarjav, Kosuke Kataoka, S. Mulyatno, Makoto Fukui, H. Kanagawa and Hiro-O Ito : Nasal Flt3L gene results in mucosal immune responses to PC through induction of B-1 B cells., 第59回口腔衛生学会総会, Oct. 2010.
81.	Kosuke Kataoka, 関根伸一, バータルジャフツェルメグ, ムルヤトノサプタ, Makoto Fukui, 金川裕子 and Hiro-O Ito : 遺伝子改変植物による歯周病原菌定着阻害能を有するヒト唾液タンパク質スタセリンペプチドの発現, 第59回口腔衛生学会総会, Oct. 2010.
82.	Makoto Fukui, ムルヤトノサプタ, バータルジャフツェルメグ, Kosuke Kataoka, 林田秀明, 川崎浩二, 斎藤俊行 and Hiro-O Ito : ヒト血中および唾液中の抗ホスホリルコリン抗体の存在実態, 第59回口腔衛生学会総会, Oct. 2010.
83.	Kosuke Kataoka, 関根伸一, Makoto Fukui, Masaaki Yokoyama and Hiro-O Ito : 粘膜アジュバントCpG オリゴヌクレオチドによるPorphyromonas gingivalis 線毛抗原特異的抗体応答の誘導, 第53回日本歯周病学会秋季学術大会, Sep. 2010.
84.	Kosuke Kataoka, Makoto Fukui, 金川裕子 and Hiro-O Ito : ヒト唾液タンパク質由来ペプチドの歯周病菌定着阻害効果, 第21回近畿・中国・四国口腔衛生学会総会, Jun. 2010.
85.	Makoto Fukui, サプタムルヤトノ, バータルジャフツェルメグ, Kosuke Kataoka and Hiro-O Ito : ヒトの唾液中および血中に存在する抗ホスホリルコリン抗体の検出, 第21回近畿・中国・四国口腔衛生学会総会, Jun. 2010.
86.	Masakazu Misaki, 渋谷敦人, Jurou Okada, 阿部直樹, 豊嶋健治, Makoto Fukui, Kosuke Kataoka, Hiro-O Ito and 弘文奥 : 平成21年度に香川県内で実施された成人歯科健診モデル事業実施報告, 第21回近畿・中国・四国口腔衛生学会総会, Jun. 2010.
87.	Kosuke Kataoka, Haruo Nakagaki, 関根伸一, Makoto Fukui, Hiro-O Ito and Satoshi Shizukuishi : Fusobacterium nucleatum表層タンパク質FomAと唾液高チロシンタンパク質スタセリンペプチドとの相互作用, 第53回日本歯周病学会春季学術大会, May 2010.
88.	Kosuke Kataoka, Hiro-O Ito, Makoto Fukui, Baatarjav Tselmeg and 藤橋浩太郎 : Induction of PC-specific T15 idiotype Ab in mucosal secretion by Flt3 ligand plasmid as a mucosal adjuvant, 日本免疫学会総会学術集会記録, Vol.39, 193, Dec. 2009.
89.	Yuka Sogawa, Masaaki Yokoyama, 幸江真杉, Harumi Sakamoto, Makoto Fukui, Nozomi Yokoyama, Kanako Tamatani, Masami Yoshioka and Daisuke Hinode : 徳島大学病院における妊婦の口腔保健の現状と今後の課題, Journal of Dental Health, Vol.59, No.4, 493, Oct. 2009. (Keyword) enquête
90.	バータルジャフツェルメグ, ムルヤトノサプタ, 金川裕子, Kosuke Kataoka, Hiro-O Ito and Makoto Fukui : 唾液タンパク質由来ペプチド複合体による歯周病菌定着阻害能の検討, 第59回日本口腔衛生学会総会(岐阜市，長良川国際会議場) 口腔衛生学会雑誌, Vol.59, No.4, 349, Oct. 2009.
91.	岡田寿朗, 三崎昌和, 佐々木浩司, 武部裕光, 山下喜世弘, Makoto Fukui, Hiro-O Ito and 奥弘文 : 香川県内で実施された歯科保健指導モデル事業報告, 第20回日本口腔衛生学会近畿·中国·四国地方会 (広島国際会議場), Jun. 2009.
92.	Makoto Fukui and Hiro-O Ito : フゾバクテリウム反応性唾液sIgA抗体と舌苔との関連性, 第20回日本口腔衛生学会近畿·中国·四国地方会 (広島国際会議場), Jun. 2009.
93.	Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, バータルジャフツェルメグ, Kosuke Kataoka and Hiro-O Ito : フゾバクテリウム反応性唾液sIgA抗体と舌苔との関連性, Journal of Dental Health, Vol.59, No.5, 606-607, Jun. 2009. (Keyword) *Secretory IgA
94.	万井正章, 宇野賀津子, Makoto Fukui and Hiro-O Ito : 唾液中サイトカイン測定の健康診査への応用に関する研究, 第74回日本インターフェロン・サイトカイン学会学術集会(京都大学芝蘭会館), Jun. 2009.
95.	Hiro-O Ito, B. ツェルメグ, Kosuke Kataoka and Makoto Fukui : 肺炎球菌抗原とDNAアジュバント経鼻投与による粘膜免疫応答の解析, 第20回日本口腔衛生学会近畿·中国·四国地方会 (広島国際会議場), Jun. 2009.
96.	Masami Yoshioka, Masaaki Yokoyama, Makoto Fukui, Yoko Abe, 裕美藤井, 薫廣瀬, Yumi Hoshimo, Naoko Matsumoto and 菊恵木田 : 徳島大学病院ICUにおける専門的口腔ケアの取り組み, Journal of Dental Health, Vol.58, No.5, 558, Oct. 2008.
97.	Jurou Okada, Masakazu Misaki, 浩司佐々木, 裕光武部, 喜世弘山下, Masaaki Yokoyama, Makoto Fukui, Hiro-O Ito and 弘文奥 : 香川県内で実施された成人歯科健診モデル事業報告, The Journal of the Japan Dental Association, Vol.61, No.5, 555, Aug. 2008.
98.	Daisuke Hinode, Masaaki Yokoyama, Makoto Fukui and Masami Yoshioka : 口臭外来受診患者の喫煙状況と口臭に対する喫煙経験の影響, 第2回日本禁煙科学会学術総会, Dec. 2007.
99.	Masaaki Yokoyama, Makoto Fukui, Tomoaki Honna, Natsuko Takamatsu, Kaname Masuda and Hiro-O Ito : 口腔清潔度の指標としての唾液中総細菌数, Journal of Dental Health, Vol.57, No.5, 692, Oct. 2007.
100.	Jurou Okada, Masakazu Misaki, 浩司佐々木, 稔之亀井, 裕光武部, 喜世弘山下, Masaaki Yokoyama, Makoto Fukui, Hiro-O Ito and 弘文奥 : 香川県内で実施された成人歯科健診モデル事業報告, Journal of Dental Health, Vol.57, No.5, 689, Oct. 2007.
101.	Yuka Sogawa, Harumi Sakamoto, Masaaki Yokoyama, Makoto Fukui, Nozomi Yokoyama, Kanako Tamatani, 寿代佐野, Masami Yoshioka and Daisuke Hinode : 徳島大学病院における妊婦の口腔保健向上のための取り組み, Journal of Dental Health, Vol.57, No.5, 689, Oct. 2007.
102.	Masami Yoshioka, 裕美藤井, Yuka Sogawa, Harumi Sakamoto, 薫廣瀬, Makoto Fukui, Masaaki Yokoyama and Daisuke Hinode : 急性期病院の脳神経外科/神経内科病棟および脳卒中センターにおける専門的口腔ケアのニーズ, Journal of Dental Health, Vol.57, No.4, 569, Aug. 2007.
103.	Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, Masami Yoshioka and Hiro-O Ito : 口臭患者における唾液ストレスマーカーの評価, Journal of Dental Health, Vol.57, No.4, 482, Aug. 2007.
104.	Natsuko Takamatsu, Kaname Masuda, Makoto Fukui, Masaaki Yokoyama, Masami Yoshioka and Hiro-O Ito : 歯根面う蝕のリスクファクター調査, Journal of Dental Health, Vol.57, No.4, 423, Aug. 2007.
105.	Masaaki Yokoyama, Daisuke Hinode, Makoto Fukui, Masami Yoshioka and Hiro-O Ito : 歯周病原細菌Campylobacter rectusと妊娠期の歯周状態との関連性, Journal of the Japanese Association of Periodontology, Vol.49, 176, Aug. 2007.
106.	Masaaki Yokoyama, Daisuke Hinode, Makoto Fukui, Masami Yoshioka and Hiro-O Ito : Relationship between Campylobacter rectus and periodontal status during pregnancy, 「魅力ある大学院教育」イニシアティブ・第1回国際シンポジウム, Mar. 2007.
107.	裕美藤井, 薫廣瀬, Harumi Sakamoto, Yuka Sogawa, Akiko Satoh, Makoto Fukui, Masaaki Yokoyama, Masami Yoshioka and Daisuke Hinode : 徳島大学病院栄養サポートチームにおける専門的口腔ケアの取り組み第2報, Journal of Dental Health, Vol.56, No.5, 723-724, Oct. 2006.
108.	Masami Yoshioka, Tomoaki Honna, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kaname Masuda, Daisuke Hinode and Hiro-O Ito : 学校歯科健診における歯肉炎の評価についての考察, Journal of Dental Health, Vol.56, No.5, 723, Oct. 2006.
109.	Masaaki Yokoyama, Daisuke Hinode, Makoto Fukui, Shin-ichi Tanabe, Masami Yoshioka and Hiro-O Ito : 妊婦における歯周疾患と唾液中の女性ホルモンおよび血管内皮増殖因子(VEGF)の関連性, Journal of Dental Health, Vol.56, No.4, 593, Aug. 2006.
110.	Shin-ichi Tanabe, Masaaki Yokoyama, Makoto Fukui, Tomoaki Honna, Kanako Tamatani, Nozomi Yokoyama, Masami Yoshioka, 森達哉 and Daisuke Hinode : 口腔ケア活動による介護老人福祉施設職員の意識・行動の変化, Journal of Dental Health, Vol.55, No.5, 630, Oct. 2005.
111.	Makoto Fukui, Masami Yoshioka, Tomoaki Honna, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani, Nozomi Yokoyama, Kaname Masuda, Daisuke Hinode and Ryo Nakamura : フッ化物洗口実施校におけるう蝕予防効果─歯群別分析および乳歯う蝕と永久歯う蝕の関連性についての分析─, Journal of Dental Health, Vol.55, No.4, 423, Aug. 2005.
112.	Shin-ichi Tanabe, Masaaki Yokoyama, Makoto Fukui, Masami Yoshioka and Daisuke Hinode : 要介護高齢者口腔ケア実習に対する歯学部学生の意識調査, 第24回日本歯科医学教育学会総会・学術大会, Jul. 2005.
113.	Makoto Fukui, Kaname Masuda, Kanako Tamatani, Tomoaki Honna and Daisuke Hinode : Relationship between periodontal conditions and sIgA directed to microbial GroEL., Journal of Dental Research, Nov. 2004.
114.	Masami Yoshioka, Tomoaki Honna, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani and Daisuke Hinode : 徳島県K村における児童生徒のう蝕罹患状況─10年間のフッ化物洗口の効果と今後の課題─, Journal of Dental Health, Vol.54, No.5, 589, Oct. 2004.
115.	Daisuke Hinode, Makoto Fukui, Shin-ichi Tanabe, Tomoaki Honna, Kaname Masuda and Masami Yoshioka : 歯周病原性細菌 Actinobacillus actinomycetemcomitans 由来 GroELとヒトファイブロネクチンの分子相同性, Journal of Dental Health, Vol.54, No.4, 451, Sep. 2004.
116.	Masami Yoshioka, Daniel Grenier, Denis Mayrand, Masaaki Yokoyama, Makoto Fukui, Kanako Tamatani and Daisuke Hinode : Lipopolysaccharides bound to Peptostreptococcus micros induce TNF-α production by U937, 51st Annual Meeting of the Japanese Association for Dental Research, Dec. 2003.
117.	Masaaki Yokoyama, Tomoaki Honna, Kanako Tamatani, Shin-ichi Tanabe, Nozomi Yokoyama, Makoto Fukui, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : 定期的口腔健康管理を受けている者の現在歯数の変化について, Journal of Dental Health, Vol.53, No.5, 618, Oct. 2003.
118.	Masami Yoshioka, Nozomi Yokoyama, Masaaki Yokoyama, Makoto Fukui and Daisuke Hinode : Peptostreptococcus micros によるヒトモノサイトのサイトカイン誘導, Journal of Dental Health, Vol.53, No.4, 618, Sep. 2003.
119.	Makoto Fukui, 赤木毅, Nozomi Yokoyama, Masami Yoshioka, Kanako Tamatani, 嶋田順子, Daisuke Hinode and Ryo Nakamura : 口臭患者における舌苔と唾液中分泌型IgAレベルとの関連性, Journal of Dental Health, Vol.52, No.5, 723, Oct. 2002.
120.	Shin-ichi Tanabe, Masaaki Yokoyama, Makoto Fukui, Tomoaki Honna, Daisuke Hinode and Ryo Nakamura : 介護老人福祉施設利用者の口腔内状態について, Journal of Dental Health, Vol.52, No.5, 725-726, Oct. 2002.
121.	Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Daisuke Hinode and Ryo Nakamura : 熱ショックタンパク質に対する唾液分泌型IgA抗体と歯周病との関連性, Journal of Dental Health, Vol.52, No.4, 548-549, Aug. 2002.
122.	Masaaki Yokoyama, Shin-ichi Tanabe, Makoto Fukui, Junko Shimada, Kanako Tamatani, Daisuke Hinode and Ryo Nakamura : 骨結合型インプラント治療に対する喫煙の影響, Journal of Dental Health, Vol.51, No.4, 857, Oct. 2001.
123.	Nozomi Yokoyama, Masami Yoshioka, Shin-ichi Tanabe, Tsuyoshi Akagi, Makoto Fukui, Daisuke Hinode and Ryo Nakamura : ヒト歯肉細胞由来マトリックスメタロプロテアーゼに対する阻害剤の影響, Journal of Dental Health, Vol.51, No.4, 554-555, Sep. 2001.
124.	Kaname Masuda, Masami Yoshioka, Makoto Fukui, 赤木毅 and Kanako Tamatani : Localization of Arginine Carboxypeptidase in Porphyromonas gingivalis, Journal of Dental Research, Dec. 2000.
125.	Tsuyoshi Akagi, Daisuke Hinode, Kaname Masuda, Shin-ichi Tanabe, Makoto Fukui, Masami Yoshioka and Ryo Nakamura : Campylobacter rectus とHelicobacter pylori の共通抗原, Journal of Dental Health, Vol.50, No.4, 592-593, Sep. 2000.

Et cetera, Workshop:

1.	Makoto Fukui, 早渕純子, 西尾よしみ, 武内早苗, 小百合横山, Yumiko Izaki, Hiro-O Ito and Kenichi Maeda : 歯科検診10年の取り組み, 全国大学保健管理研究集会プログラム・抄録集, 51, Sep. 2016. (Keyword) *口腔保健

Patent:

1.	Kazuhito Satomura, Hiroaki Nakanishi, Masami Yoshioka, Makoto Fukui, 横田利夫 and 松本正志 : 歯周病用光治療器, 2006-026905 (Feb. 2006), 4707063 (Mar. 2011).

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

行動変容を導く保健関連因子の探索と国際的視点での口腔保健アウトカムへの介入効果 (Project/Area Number: 23K09481 )
歯科保健行動への介入を起点とした共通リスクファクターアプローチによるNCDs予防 (Project/Area Number: 21K10246 )
高齢者の肺炎および口臭予防を目的とした新規口腔環境改善手法の確立 (Project/Area Number: 21K10228 )
オーラルフレイル対策を包含したコモンリスクファクターアプローチによる介護予防戦略 (Project/Area Number: 19K10445 )
Elucidation of oral environmental factors involved in adverse events of patients undergoing cancer chemotherapy (Project/Area Number: 19K10432 )
Establishment of dental health services for pregnant woman aiming to improve health disparities (Project/Area Number: 18K09881 )
Antioxidant Activity of Cat's claw Extract as Natural Herb and its Preventive Effects on Periodontal Disease (Project/Area Number: 16K11859 )
Developing an objective method for diagnosing periodontal inflammation using saliva. (Project/Area Number: 26463164 )
Development of a novel diagnosis system for periodontal disease by objective biochemical laboratory tests for salivary biomarkers. (Project/Area Number: 26293442 )
Decision of a normal range of cytokines in human saliva. (Project/Area Number: 23593091 )
Development of high-throughput analysis formouth odor (Project/Area Number: 22592336 )
The influence of coaggregation for a volatile sulfide production of Fusobacterium (Project/Area Number: 21792153 )
The role of anti Fusobacterium nucreatum salivary sIgA antibody for accumulation of tongue coating. (Project/Area Number: 19791636 )
Analysis of salivary amino acids associated with physiologichalitosis and investigation of inhbitor against oral malodor (Project/Area Number: 19592407 )
Elucidation of mechanism of enhanced innate salivary-IgA antibody to Thymus-independent antigen (Project/Area Number: 19592403 )
青色レーザーの歯周病原菌増殖抑制効果を利用した新規歯周病治療法の開発 (Project/Area Number: 17659662 )
Studies on the practical use of soybean peptides for oral health promotion in the elderly (Project/Area Number: 17592182 )
The prediction of periodontal condition by the measurement of the antibody titers directed to heat shock proteins (Project/Area Number: 12557184 )
Search by Researcher Number (50325289)

Associate Professor : Fukui, Makoto

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)