Tokushima University / Educator and Researcher Directory --- Matsui, Naoko

Personal Web Page

https://researchmap.jp/000337 (researchmap)

Field of Study

○	Medicine
○	神経免疫

Subject of Study

○
○	重症筋無力症の発症メカニズム (重症筋無力症, 胸腺)

Book / Paper

Book:

1.	Naoko Matsui and Yuishin Izumi : 9．末梢神経障害多巣性運動ニューロパチー(MMN), 株式会社総合医学社, May 2021.

Academic Paper (Judged Full Paper):

1.	Naoko Matsui, Keiko Tanaka, Mitsuyo Ishida, Yohei Yamamoto, Yuri Matsubara, Reiko Saika, Takahiro Iizuka, Koshi Nakamura, Nagato Kuriyama, Makoto Matsui, Kokichi Arisawa, Yosikazu Nakamura, Ryuji Kaji, Satoshi Kuwabara and Yuishin Izumi : Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey., Neurology® Neuroimmunology & Neuroinflammation, Vol.10, No.6, e200165, 2023. (Summary) This study provides the current epidemiologic and clinical status of SPS in Japan. The symptom onset to the diagnosis of SPS was longer in patients with high-titer GAD65 antibodies than in those with low-titer GAD65 antibodies. The outcome of patients with SPS was generally favorable, but more aggressive immunotherapies are necessary for GAD65-positive patients with SPS. (Keyword) Adult / Aged / Aged, 80 and over / Female / Humans / Male / Middle Aged / Antibodies / East Asian People / Glutamate Decarboxylase / Immunotherapy / Prevalence / Prognosis / Stiff-Person Syndrome (Tokushima University Institutional Repository) ● Metadata: 118945 (Link to Publication Site) ● Publication site (DOI): 10.1212/NXI.0000000000200165 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37739810 ● Search Scopus @ Elsevier (PMID): 37739810 ● Search Scopus @ Elsevier (DOI): 10.1212/NXI.0000000000200165 (Tokushima University Institutional Repository: 118945, DOI: 10.1212/NXI.0000000000200165, PubMed: 37739810)
2.	Yosuke Yamada, Djeda Belharazem-Vitacolonnna, Hanibal Bohnenberger, Christel Weiß, Naoko Matsui, Mark Kriegsmann, Katharina Kriegsmann, Peter Sinn, Katja Simon-Keller, Gerhard Hamilton, Thomas Graeter, Gerhard Preissler, German Ott, Sebastian Schölch, Naoki Nakajima, Akihiko Yoshizawa, Hironori Haga, Hiroshi Date, Roman K Thomas, Iacopo Petrini, Giuseppe Giaccone, Philipp Ströbel and Alexander Marx : Pulmonary cancers across different histotypes share hybrid tuft cell/ionocyte-like molecular features and potentially druggable vulnerabilities, Cell Death & Disease, Vol.13, No.11, 979, 2022. (Link to Publication Site) ● Publication site (DOI): 10.1038/s41419-022-05428-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36402755 ● Summary page in Scopus @ Elsevier: 2-s2.0-85142267950 (DOI: 10.1038/s41419-022-05428-x, PubMed: 36402755, Elsevier: Scopus)
3.	Naoko Matsui, Mika Takahara, Hiroki Yamazaki, Naoko Takamatsu, Yusuke Osaki, Ryuji Kaji, Ichizo Nishino, Satoshi Yamashita and Yuishin Izumi : A case of anti-NT5c1A antibody-seropositive inclusion body myositis associated with severe dysphagia and prominent forearm weakness, Neurology and Clinical Neuroscience, Vol.11, No.1, 46-48, 2022. (Link to Publication Site) ● Publication site (DOI): 10.1111/ncn3.12678 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1111/ncn3.12678 (DOI: 10.1111/ncn3.12678)
4.	Yu Hiramatsu, Yuji Okamoto, Akiko Yoshimura, JunHui Yuan, Masahiro Ando, Yujiro Higuchi, Akihiro Hashiguchi, Eiji Matsuura, Fumihito Nozaki, Tomohiro Kumada, Kei Murayama, Mikiya Suzuki, Yuki Yamamoto, Naoko Matsui, Yoshimichi Miyazaki, Masamitsu Yamaguchi, Youji Suzuki, Jun Mitsui, Hiroyuki Ishiura, Masaki Tanaka, Shinichi Morishita, Ichizo Nishino, Shoji Tsuji and Hiroshi Takashima : Complex hereditary peripheral neuropathies caused by novel variants in mitochondrial-related nuclear genes, Journal of Neurology, Vol.269, No.8, 4129-4140, 2022. (Summary) Mitochondrial disorders are a group of clinically and genetically heterogeneous multisystem disorders and peripheral neuropathy is frequently described in the context of mutations in mitochondrial-related nuclear genes. This study aimed to identify the causative mutations in mitochondrial-related nuclear genes in suspected hereditary peripheral neuropathy patients. We enrolled a large Japanese cohort of clinically suspected hereditary peripheral neuropathy patients who were mutation negative in the prescreening of the known Charcot-Marie-Tooth disease-causing genes. We performed whole-exome sequencing on 247 patients with autosomal recessive or sporadic inheritance for further analysis of 167 mitochondrial-related nuclear genes. We detected novel bi-allelic likely pathogenic/pathogenic variants in four patients, from four mitochondrial-related nuclear genes: pyruvate dehydrogenase beta-polypeptide (PDHB), mitochondrial poly(A) polymerase (MTPAP), hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, beta subunit (HADHB), and succinate-CoA ligase ADP-forming beta subunit (SUCLA2). All these patients showed sensory and motor axonal polyneuropathy, combined with central nervous system or multisystem involvements. The pathological analysis of skeletal muscles revealed mild neurogenic changes without significant mitochondrial abnormalities. Targeted screening of mitochondria-related nuclear genes should be considered for patients with complex hereditary axonal polyneuropathy, accompanied by central nervous system dysfunctions, or with unexplainable multisystem disorders. (Keyword) Charcot-Marie-Tooth Disease / Coenzyme A / DNA, Mitochondrial / Humans / Mitochondrial Diseases / Mutation / Oxidoreductases (Link to Publication Site) ● Publication site (DOI): 10.1007/s00415-022-11026-w (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35235001 ● Search Scopus @ Elsevier (PMID): 35235001 ● Search Scopus @ Elsevier (DOI): 10.1007/s00415-022-11026-w (DOI: 10.1007/s00415-022-11026-w, PubMed: 35235001)
5.	Hiroki Yamazaki, Naoko Matsui, N Takamatsu, Takeshi Yoshida, Koji Fukushima, T Takata, Yusuke Osaki, K Tanaka, Y Kubo and Yuishin Izumi : Application of ultrasound in a case of eosinophilic fasciitis mimicking stiff-person syndrome, Neuromuscular Disorders, Vol.32, No.7, 590-593, 2022. (Summary) Eosinophilic fasciitis (EF) is a rare disorder characterized by muscle stiffness mimicking other neuromuscular diseases. The diagnosis of EF is made on the basis of typical skin lesions. We report a case of a 36-year-old male patient with suspected stiff-person syndrome (SPS), who presented with progressive limb muscle stiffness and limited mobility of both wrists without obvious skin changes. Ultrasound revealed fascial thickening of bilateral upper and lower limb muscles and enlargement of hypoechoic tissues around the flexor digitorum tendons of the wrist. Skin and fascia biopsy confirmed the diagnosis of EF. Prednisolone therapy resulted in the improvement of muscle stiffness and tightness. Our findings suggest the need to consider connective tissue diseases such as EF in a patient with atypical features of SPS. Ultrasound is helpful for visualizing the causes of muscle stiffness and joint contractures in EF patients. (Keyword) Adult / Eosinophilia / Fasciitis / Humans / Male / Prednisolone / Stiff-Person Syndrome (Link to Publication Site) ● Publication site (DOI): 10.1016/j.nmd.2022.05.009 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35672204 ● Search Scopus @ Elsevier (PMID): 35672204 ● Search Scopus @ Elsevier (DOI): 10.1016/j.nmd.2022.05.009 (DOI: 10.1016/j.nmd.2022.05.009, PubMed: 35672204)
6.	Yohei Yamamoto, Naoko Matsui, Akiyuki Uzawa, Yukiko Ozawa, Tetsuya Kanai, Fumiko Oda, Hiroyuki Kondo, Izumi Ohigashi, Hiromitsu Takizawa, Kazuya Kondo, Mikio Sugano, Takashi Kitaichi, Hiroki Hata, Ryuji Kaji, Satoshi Kuwabara, Takashi Yamamura and Yuishin Izumi : Intrathymic Plasmablasts Are Affected in Patients With Myasthenia Gravis With Active Disease., Neurology® Neuroimmunology & Neuroinflammation, Vol.8, No.6, e1087, 2021. (Summary) Our findings confirmed a correlation between increased frequency of intrathymic plasmablasts and disease activity before thymectomy. We postulate that activated intrathymic plasmablasts endow pathogenic capacity in MG. (Keyword) Adolescent / adult / Aged / B-Lymphocytes / children / Child, Preschool / female / Humans / Leukocytes, Mononuclear / Lymphopoiesis / male / Middle Aged / Myasthenia Gravis / Stem Cells / T lymphocytes / Thymectomy / Thymoma / Thymus Neoplasms / Young Adult (Tokushima University Institutional Repository) ● Metadata: 116884 (Link to Publication Site) ● Publication site (DOI): 10.1212/NXI.0000000000001087 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34561276 ● Summary page in Scopus @ Elsevier: 2-s2.0-85117018419 (Tokushima University Institutional Repository: 116884, DOI: 10.1212/NXI.0000000000001087, PubMed: 34561276, Elsevier: Scopus)
7.	Naoko Matsui, 田中惠子 and Yuishin Izumi : Stiff-Person Syndrome, Brain and Nerve = Shinkei kenkyū no shinpo, Vol.73, No.5, 640-646, 2021. (Keyword) stiff-person syndrome / muscle rigidity / spasm / paraneoplastic syndrome / autoantibody (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1523951030927469056 (CiNii: 1523951030927469056)
8.	T Fukumoto, Ryosuke Miyamoto, Koji Fujita, N Murakami, Naoko Matsui and Yuishin Izumi : Reversible mixed perfusion on 123 I-IMP SPECT in anti-AMPA receptor encephalitis: A case report, Journal of the Neurological Sciences, Vol.421, 117306, 2021. (Keyword) Encephalitis / Humans / Inosine Monophosphate / Iodine Radioisotopes / Iofetamine / Perfusion / Receptors, AMPA / Tomography, Emission-Computed, Single-Photon (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jns.2020.117306 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33450618 ● Search Scopus @ Elsevier (PMID): 33450618 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2020.117306 (DOI: 10.1016/j.jns.2020.117306, PubMed: 33450618)
9.	M Yoshida, K Kondo, Naoko Matsui, Yuishin Izumi, Y Bando, M Yokoishi, K Kajiura and Akira Tangoku : Prediction of improvement after extended thymectomy in non-thymomatous myasthenia gravis patients, PLoS ONE, Vol.15, No.10, e0239756, 2020. (Summary) It is popularly believed that myasthenia gravis (MG) patients show acetylcholine receptor antibody (AChRAb) production associated with the thymus (germinal centers, approximately 80%). It has been suggested that thymectomy can remove the area of autoantibody production. This study aimed to determine whether the solid volume of the thymus calculated using three-dimensional (3D) imaging could be used to predict the efficacy of thymectomy. Additionally, the study assessed the relationships of the solid volume with germinal centers, change in the serum AChRAb level, postoperative MG improvement, and prednisolone (PSL) dose reduction extent. This retrospective study included 12 consecutive non-thymomatous MG patients (9 female and 3 male patients), who underwent extended thymectomy at our institution over the last 10 years. The mean patient age was 43.3 ± 14.2 years (range, 12-59 years). The study assessed the number of germinal centers per unit area, change in the serum AChRAb level, postoperative MG improvement, PSL dose reduction extent, and solid volume of the thymus. The number of germinal centers per unit area was significantly correlated with the solid volume of the thymus. The PSL dose reduction extent tended to be correlated with the solid volume. Our findings suggest that the solid volume of the thymus can possibly predict steroid dose reduction. Additionally, the solid volume of the thymus in 3D images is the most important indicator for predicting the efficacy of extended thymectomy. (Keyword) Adult / Autoantibodies / Female / Humans / Male / Myasthenia Gravis / Receptors, Cholinergic / Retrospective Studies / Thymectomy / Thymoma / Thymus Neoplasms (Tokushima University Institutional Repository) ● Metadata: 116622 (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0239756 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33017427 ● Search Scopus @ Elsevier (PMID): 33017427 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0239756 (Tokushima University Institutional Repository: 116622, DOI: 10.1371/journal.pone.0239756, PubMed: 33017427)
10.	Naoko Matsui, Hiroyuki Nodera, D Kuzume, N Iwasa, Y Unai, W Sakai, Y Miyazaki, H Yamazaki, Yusuke Osaki, A Mori, T Furukawa, A Tsukamoto-Miyashiro, Y Shimatani, M Yamasaki, Yuishin Izumi, S Kusunoki, Kokichi Arisawa and Ryuji Kaji : Guillan-Barre syndrome in local area in Japan, 2006-2015: an epidemiological and clinical study of 108 patients, European Journal of Neurology, Vol.25, No.5, 718-724, 2018. (Summary) Many epidemiological studies of Guillain-Barré syndrome (GBS) and Fisher syndrome (FS) have been conducted in Europe and America. In contrast, epidemiological studies are rare in Asia where the GBS subtypes differ from those in Western countries. This study was undertaken to clarify the incidence of GBS and FS in a local area in Japan as well as their seasonal trends. Seventy-one GBS and 37 FS patients were recorded from 2006 to 2015 in an area of approximately 1.5 million inhabitants in Japan. The incidence, seasonal trends and clinical features of GBS and FS were examined. The incidence rate of GBS was 0.42 cases per 100 000 person-years and that of FS was 0.22 cases per 100 000 person-years. The incidence of GBS increased with age and FS affected predominantly patients aged from 45 to 64 years old. There was some seasonal clustering of acute motor axonal neuropathy (AMAN) and FS in spring and summer, but it was not significant. AMAN and FS patients had a high frequency of preceding infection (AMAN, 68% gastrointestinal infection; FS, 65% upper respiratory infection). Antecedent respiratory infection was significantly associated with FS as an outcome. Serum antibodies to ganglioside GM1 were detected in 71% of AMAN patients and antibodies to GQ1b were detected in 81% of FS patients. Our study offers evidence of a lower incidence of GBS and a higher incidence of FS in a local area in Japan than in Western countries. (Link to Publication Site) ● Publication site (DOI): 10.1111/ene.13569 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29337417 ● Summary page in Scopus @ Elsevier: 2-s2.0-85042582939 (DOI: 10.1111/ene.13569, PubMed: 29337417, Elsevier: Scopus)
11.	山上圭, Takahiro Furukawa, Yusuke Osaki, 村上永尚, 中道一生, 西條政幸, Naoko Matsui, Yuishin Izumi and Ryuji Kaji : 未治療のサルコイドーシスに合併した進行性多巣性白質脳症, Neuroinfection, Vol.23, No.1, 151-156, 2018.
12.	Misawa Sonoko, Kuwabara Satoshi, Sato Yasunori, Yamaguchi Nobuko, Nagashima Kengo, Katayama Kanako, Sekiguchi Yukari, Iwai Yuta, Amino Hiroshi, Suichi Tomoki, Yokota Takanori, Nishida Yoichiro, Kanouchi Tadashi, Kohara Nobuo, Kawamoto Michi, Ishii Junko, Kuwabara Motoi, Suzuki Hidekazu, Hirata Koichi, Kokubun Norito, Masuda Ray, Kaneko Juntaro, Yabe Ichiro, Sasaki Hidenao, Kaida Ken-ichi, Takazaki Hiroshi, Suzuki Norihiro, Suzuki Shigeaki, Hiroyuki Nodera, Naoko Matsui, Tsuji Shoji, Koike Haruki, Yamasaki Ryo and Kusunki Susumu : Safety and efficacy of eculizumab in Guillain-Barré syndrome: a multicentre, double-blind, randomised phase 2 trial., The Lancet Neurology, Vol.17, No.6, 519-529, 2018. (Summary) Despite the introduction of plasmapheresis and immunoglobulin therapy, many patients with Guillain-Barré syndrome still have an incomplete recovery. Evidence from pathogenesis studies suggests the involvement of complement-mediated peripheral nerve damage. We aimed to investigate the safety and efficacy of eculizumab, a humanised monoclonal antibody against the complement protein C5, in patients with severe Guillain-Barré syndrome. This study was a 24 week, multicentre, double-blind, placebo-controlled, randomised phase 2 trial done at 13 hospitals in Japan. Eligible patients with Guillain-Barré syndrome were aged 18 years or older and could not walk independently (Guillain-Barré syndrome functional grade 3-5). Patients were randomly assigned (2:1) to receive 4 weeks of intravenous immunoglobulin plus either eculizumab (900 mg) or placebo; randomisation was done via a computer-generated process and web response system with minimisation for functional grade and age. The study had a parallel non-comparative single-arm outcome measure. The primary outcomes were efficacy (the proportion of patients with restored ability to walk independently [functional grade 2] at week 4) in the eculizumab group and safety in the full analysis set. For the efficacy endpoint, we predefined a response rate threshold of the lower 90% CI boundary exceeding 50%. This trial is registered with ClinicalTrials.gov, number, NCT02493725. Between Aug 10, 2015, and April 21, 2016, 34 patients were assigned to receive either eculizumab (n=23) or placebo (n=11). At week 4, the proportion of the patients able to walk independently (functional grade 2) was 61% (90% CI 42-78; n=14) in the eculizumab group, and 45% (20-73; n=5) in the placebo group. Adverse events occurred in all 34 patients. Three patients had serious adverse events: two in the eculizumab group (anaphylaxis in one patient and intracranial haemorrhage and abscess in another patient) and one in the placebo group (depression). The possibility that anaphylaxis and intracranial abscess were related to eculizumab could not be excluded. No deaths or meningococcal infections occurred. The primary outcome measure did not reach the predefined response rate. However, because this is a small study without statistical comparison with the placebo group, the efficacy and safety of eculizumab could be investigated in larger, randomised controlled trials. The Japan Agency for Medical Research and Development, Ministry of Health, Labor and Welfare, and Alexion Pharmaceuticals. (Link to Publication Site) ● Publication site (DOI): 10.1016/S1474-4422(18)30114-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29685815 ● Summary page in Scopus @ Elsevier: 2-s2.0-85045902073 (DOI: 10.1016/S1474-4422(18)30114-5, PubMed: 29685815, Elsevier: Scopus)
13.	Muto Kohei, Naoko Matsui, Unai Yuki, Sakai Waka, Haji Shotaro, Udaka Kengo, Hirokazu Miki, Takahiro Furukawa, Masahiro Abe and Ryuji Kaji : Memory B cell resurgence requires repeated rituximab in myasthenia gravis, Neuromuscular Disorders, Vol.27, No.16, 918-922, 2017. (Summary) The immunologic effects of rituximab (RTX) in myasthenia gravis (MG) remain to be explored. We aimed to clarify immunologic reactions and their association with response to RTX in MG. Regulatory T cell and B cell profiles of MG patients were monitored. Two patients presenting with generalized MG with anti-acetylcholine receptor antibodies were treated with RTX. The treatment led to sustained clinical improvement, discontinuation of intravenous immunoglobulin or plasma exchange, and reduction of prednisolone and other drugs. One patient was in remission for more than one year, whereas the other patient exhibited deterioration of symptoms within one year. Disease activity was associated with the repopulation of IgDCD27 and IgDCD27 memory B cells. Clinicians should be aware of the possibility that MG ranges in the duration of B cell depletion and additional RTX should be prescribed upon resurgence of memory B cells. (Keyword) Adult / Autoantibodies / B-Lymphocytes / Female / Humans / Immunoglobulins, Intravenous / Immunologic Factors / Middle Aged / Myasthenia Gravis / Receptors, Cholinergic / Rituximab / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1016/j.nmd.2017.06.012 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28694074 ● Search Scopus @ Elsevier (PMID): 28694074 ● Search Scopus @ Elsevier (DOI): 10.1016/j.nmd.2017.06.012 (DOI: 10.1016/j.nmd.2017.06.012, PubMed: 28694074)
14.	Yuki Yamamoto, Naoko Matsui, 平松有, Yoshimichi Miyazaki, Hiroyuki Nodera, Yuishin Izumi, 高嶋博 and Ryuji Kaji : Mitochondrial trifunctional protein deficiency: an adult patient with similar progress to Charcot-Marie-Tooth disease., Clinical Neurology, Vol.57, No.2, 82-87, 2017. (Summary) A 45-year-old man presented to us due to slowly progressive muscle weakness and sensory disturbances in his lower limbs since his 40's. He reported multiple episodes of exercise-induced severe muscle fatigue and brown urine in his childhood, which disappeared by age 20. A nerve conduction study showed peripheral axonal neuropathy and then Charcot-Marie-Tooth disease (CMT) was considered as the most likely diagnosis; however, exome sequencing failed to identify a mutation in the known genes of CMTs. Since age 55, he recurrently developed severe rhabdomyolysis that required hospitalization. On suspicion of lipid metabolism disorders, we performed serum acylcarnitine analysis, and which revealed mildly elevated long-chain fatty acids. We re-examined variants obtained via exome sequencing and found a mutation in HADHB. Mitochondrial trifunctional protein (MTP) deficiency is a rare autosomal recessive disorder of mitochondrial fatty acid beta-oxidation caused by HADHA or HADHB mutation. It can be a life-threatening multiorgan disorder with early infantile onset, but it can also present in childhood or adolescence with peripheral neuropathy and recurrent rhabdomyolysis. This case of adult-diagnosed MTP deficiency was characterized by slowly progressive peripheral neuropathy masquerading CMT in addition to muscular symptoms. MTP deficiency should be considered in patients with the combination of peripheral neuropathy and recurrent rhabdomyolysis. (Keyword) Biomarkers / Cardiomyopathies / carnitine / Charcot-Marie-Tooth Disease / Diagnosis, Differential / Disease Progression / Genetic Testing / Humans / Lipid Metabolism, Inborn Errors / male / Middle Aged / Mitochondrial Myopathies / Mitochondrial Trifunctional Protein / Mitochondrial Trifunctional Protein, beta Subunit / Mutation / Nervous System Diseases / Peripheral Nervous System Diseases / Recurrence / Rhabdomyolysis (Link to Publication Site) ● Publication site (DOI): 10.5692/clinicalneurol.cn-000976 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28132977 ● Summary page in Scopus @ Elsevier: 2-s2.0-85017414707 (DOI: 10.5692/clinicalneurol.cn-000976, PubMed: 28132977, Elsevier: Scopus)
15.	Takahiro Furukawa, Naoko Matsui, 田中惠子, Yuishin Izumi and Ryuji Kaji : A case of neuromyelitis optica spectrum disorder (NMOSD) with Sjögren's syndrome manifested only brain involvement by preceding parotitis., Clinical Neurology, Vol.57, No.2, 77-81, 2017. (Summary) A 33 year-old woman presented with intentional incontinence, motor aphasia, supranuclear gaze palsy, and spasticity after parotitis. Brain magnetic resonance images (MRI) showed abnormal signaling in long corticospinal tract involving internal capsules and cerebral peduncles, middle cerebellar peduncle, and frontal subcortical white matter lesions. She had a long history of dry eye and mouth. Immunoserological study showed that she was positive for anti-SS-A, aquaporin 4 (AQP4), and AQP5 antibodies. She clinically showed not only Sjögren's syndrome but also neuromyelitis optica spectrum disorder (NMOSD) without optic neuritis or myelitis. She responded to steroid followed by plasma exchange dramatically. Thereafter, the relapse of brain lesion was once detected while tapering of steroid, but her symptoms have been stable for several years after administration of immunosuppressant. This case suggested that salivary gland inflammation might be associated with the pathogenesis of NMOSD. (Keyword) Adult / Autoantibodies / Biomarkers / brain / female / Humans / Immunosuppressive Agents / magnetic resonance imaging / Methylprednisolone / Neuromyelitis Optica / Parotitis / Plasma Exchange / Pulse Therapy, Drug / Recurrence / Sjögren's syndrome / Tacrolimus / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.5692/clinicalneurol.cn-000924 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28132975 ● Summary page in Scopus @ Elsevier: 2-s2.0-85017467963 (DOI: 10.5692/clinicalneurol.cn-000924, PubMed: 28132975, Elsevier: Scopus)
16.	Sakiya Yoshimoto, Kojiro Nagai, Eriko Shibata, Sayo Ueda, Hiroyuki Ono, Masanori Tamaki, Kenji Nishimura, Fumiaki Obata, Taizo Inagaki, Masanori Minato, Fumi Kishi, Motokazu Matsuura, Naoko Matsui, Itsuro Endo, Michael Hann, Seiji Kishi, Taichi Murakami, Hideharu Abe and Toshio Doi : Influential factors on serum albumin concentration in hospitalized chronic kidney disease patients., The Journal of Medical Investigation : JMI, Vol.64, No.1.2, 146-152, 2017. (Summary) SAC was affected by not only proteinuria, but also postural change, physical activity, and food in CKD patients. SAC should be analyzed by standardizing a patient's condition during phlebotomy. J. Med. Invest. 64: 146-152, February, 2017. (Tokushima University Institutional Repository) ● Metadata: 111103 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.64.146 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28373613 ● Summary page in Scopus @ Elsevier: 2-s2.0-85016409577 (Tokushima University Institutional Repository: 111103, DOI: 10.2152/jmi.64.146, PubMed: 28373613, Elsevier: Scopus)
17.	Takashi Abe, Toshitaka Kawarai, Koji Fujita, Wataru Sako, Yuka Terasawa, Tsuyoshi Matsuda, Waka Sakai, Ai Tsukamoto-Miyashiro, Naoko Matsui, Yuishin Izumi, Ryuji Kaji and Masafumi Harada : MR Spectroscopy in Patients with Hereditary Diffuse Leukoencephalopathy with Spheroids and Asymptomatic Carriers of Colony-stimulating Factor 1 Receptor Mutation., Magnetic Resonance in Medical Sciences, Vol.16, No.4, 297-303, 2016. (Summary) Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare neurodegenerative disorder with various clinical presentations. Mutation of the colony-stimulating factor 1 receptor (CSF1R) gene is considered to be a cause of this autosomal dominant disorder. The purpose of this study was to report magnetic resonance spectroscopy (MRS) findings in patients with HDLS and asymptomatic carriers and to clarify the use of MRS in this disease. In this retrospective, institutional review board-approved study, we included four consecutive patients, genetically diagnosed with HDLS, and two asymptomatic carriers after acquiring informed consent. We performed single-voxel MRS of the left centrum semiovale on a 3-T clinical scanner. We also included a sex-matched normal dataset. We quantified N-acetylaspartate (NAA), creatine, choline-containing compounds (Cho), glutamine, glutamate (Glu), myo-inositol (Ins), glutathione, lactate (Lac), and gamma-amino butyric acid using LCModel. We performed statistical analysis, and P value <0.05 was considered significant. In HDLS cases, MRS revealed decreased NAA and Glu concentrations, which probably reflected neuronal damage and/or loss, and a subsequent reduction of neurotransmitters. A patient with HDLS also had increased Cho and Ins concentrations, indicating gliosis, and increased Cho concentration was also observed in an asymptomatic carrier. This suggests that metabolic changes had already occurred in an asymptomatic state. We demonstrated changes in metabolite concentrations not only in patients with HDLS but also in asymptomatic CSF1R mutation carriers. Our study indicates that MRS is a potentially useful tool for the analysis of metabolic and pathophysiological findings of HDLS, even during the early stages of disease. (Tokushima University Institutional Repository) ● Metadata: 116229 (Link to Publication Site) ● Publication site (DOI): 10.2463/mrms.mp.2016-0016 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28025469 ● Summary page in Scopus @ Elsevier: 2-s2.0-85031294587 (Tokushima University Institutional Repository: 116229, DOI: 10.2463/mrms.mp.2016-0016, PubMed: 28025469, Elsevier: Scopus)
18.	Naoki Suzuki, Madoka Mori-Yoshimura, Satoshi Yamashita, Satoshi Nakano, Ken-ya Murata, Yukie Inamori, Naoko Matsui, En Kimura, Hirofumi Kusaka, Tomoyoshi Kondo, Itsuro Higuchi, Ryuji Kaji, Maki Tateyama, Rumiko Izumi, Hiroya Ono, Masaaki Kato, Hitoshi Warita, Toshiaki Takahashi, Ichizo Nishino and Masashi Aoki : Multicenter questionnaire survey for sporadic inclusion body myositis in Japan, Orphanet Journal of Rare Diseases, Vol.11, No.1, 146, 2016. (Summary) Sporadic inclusion body myositis (sIBM) is the most prevalent acquired muscle disease in the elderly. sIBM is an intractable and progressive disease of unknown cause and without effective treatment. The etiology of sIBM is still unknown; however, genetic factors, aging, lifestyles, and environmental factors may be involved. The purpose of this study is to elucidate the cross-sectional profile of patients affected by sIBM in Japan. We surveyed patient data for 146 cases diagnosed at a number of centers across Japan. We also issued a questionnaire for 67 patients and direct caregivers to further elucidate the natural history of the disease. The mean age at the onset was 63.4 ± 9.2 years. The mean length of time from the onset to diagnosis was 55.52 ± 49.72 months, suggesting that there is a difficulty in diagnosing this disease with long-term consequences because of late treatment. 73 % described the psychological/mental aspect of the disease. The most popular primary caregiver was the patient's spouse and 57 % patients mentioned that they were having problems managing the finances. Through these surveys, we described the cross-sectional profiles of sIBM in Japan. Many patients described psychological/mental and financial anxiety because of the aged profile of sIBM patients. The profiles of sIBM patients are similar to those in Western countries. (Tokushima University Institutional Repository) ● Metadata: 114517 (Link to Publication Site) ● Publication site (DOI): 10.1186/s13023-016-0524-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27821140 ● Search Scopus @ Elsevier (PMID): 27821140 ● Search Scopus @ Elsevier (DOI): 10.1186/s13023-016-0524-x (Tokushima University Institutional Repository: 114517, DOI: 10.1186/s13023-016-0524-x, PubMed: 27821140)
19.	Takahiro Furukawa, Chieko Ishifune, Shin-ichi Tsukumo, Katsuto Hozumi, Yoichi Maekawa, Naoko Matsui, Ryuji Kaji and Koji Yasutomo : Transmission of survival signals through Delta-like 1 on activated CD4(+) T cells., Scientific Reports, Vol.6, 33692, 2016. (Summary) Notch expressed on CD4(+) T cells transduces signals that mediate their effector functions and survival. Although Notch signaling is known to be cis-inhibited by Notch ligands expressed on the same cells, the role of Notch ligands on T cells remains unclear. In this report we demonstrate that the CD4(+) T cell Notch ligand Dll1 transduces signals required for their survival. Co-transfer of CD4(+) T cells from Dll1(-/-) and control mice into recipient mice followed by immunization revealed a rapid decline of CD4(+) T cells from Dll1(-/-) mice compared with control cells. Dll1(-/-) mice exhibited lower clinical scores of experimental autoimmune encephalitis than control mice. The expression of Notch target genes in CD4(+) T cells from Dll1(-/-) mice was not affected, suggesting that Dll1 deficiency in T cells does not affect cis Notch signaling. Overexpression of the intracellular domain of Dll1 in Dll1-deficient CD4(+) T cells partially rescued impaired survival. Our data demonstrate that Dll1 is an independent regulator of Notch-signaling important for the survival of activated CD4(+) T cells, and provide new insight into the physiological roles of Notch ligands as well as a regulatory mechanism important for maintaining adaptive immune responses. (Tokushima University Institutional Repository) ● Metadata: 112325 (Link to Publication Site) ● Publication site (DOI): 10.1038/srep33692 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27659682 ● Summary page in Scopus @ Elsevier: 2-s2.0-84988568998 (Tokushima University Institutional Repository: 112325, DOI: 10.1038/srep33692, PubMed: 27659682, Elsevier: Scopus)
20.	山下雄也, Hiroki Yamazaki, Naoko Matsui, Yoshimichi Miyazaki, 塚本愛, 西野一三, 鈴木重明, 西田善彦, Hiroyuki Nodera, Yuishin Izumi and Ryuji Kaji : A Case of Anti-SRP Positive Immune-mediated Necrotizing Myopathy Treated Effectively with Combined Immunotherapy, The Journal of the Japanese Society of Internal Medicine, Vol.105, No.8, 1443-1450, 2016. (Summary) <p>症例は60歳代，男性．全身倦怠感，四肢脱力を主訴に受診．筋炎としステロイド単独で治療を開始したが，反応性は乏しく，筋病理・抗体検査にて抗SRP抗体陽性壊死性ミオパチー(anti-signal recognition particle immune-mediated necrotizing myopathy:anti-SRP iNM)と診断し，免疫グロブリン大量静注療法，免疫抑制薬を併用したところ，症状の改善を得た．積極的に自己抗体の測定を行うことが壊死性ミオパチー(immune-mediated necrotizing myopathy:iNM)の早期診断・治療に重要である．</p> (Keyword) 抗SRP抗体 / 壊死性ミオパチー / 免疫グロブリン大量静注療法 / 免疫抑制薬 (Link to Publication Site) ● Publication site (DOI): 10.2169/naika.105.1443 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282681425704832 ● Search Scopus @ Elsevier (DOI): 10.2169/naika.105.1443 (DOI: 10.2169/naika.105.1443, CiNii: 1390282681425704832)
21.	Waka Sakai, Naoko Matsui, Mitsuyo Ishida, Takahiro Furukawa, Yoshimichi Miyazaki, Koji Fujita, Ryosuke Miyamoto, Nobuaki Yamamoto, Wataru Sako, Kenta Sato, Kazuya Kondo, Yoshihiko Nishida, Takao Mitsui, Yuishin Izumi and Ryuji Kaji : Late-onset myasthenia gravis is predisposed to become generalized in the elderly, eNeurologicalSci, Vol.2, 17-20, 2016. (Tokushima University Institutional Repository) ● Metadata: 110923 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ensci.2016.02.004 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ensci.2016.02.004 (Tokushima University Institutional Repository: 110923, DOI: 10.1016/j.ensci.2016.02.004)
22.	Shunya Nakane, Kaori Furutani, Masafumi Harada, Ryo Urushihara, Naoko Matsui, Yuishin Izumi and Ryuji Kaji : Multimodal analysis based on high-field magnetic resonance and motor evoked potentials: A case report of multiple sclerosis, Clinical & Experimental Neuroimmunology, Vol.8, No.1, 43-46, 2016. (Link to Publication Site) ● Publication site (DOI): 10.1111/cen3.12352 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1111/cen3.12352 (DOI: 10.1111/cen3.12352)
23.	Masaki Kamata, Shunya Nakane, Naoko Matsui, Osamu Higuchi, Sakai Waka, Koji Fujita, Yuishin Izumi, Hidenori Matsuo and Ryuji Kaji : Ocular myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies: Two new cases and a systematic literature review, Clinical & Experimental Neuroimmunology, Vol.7, No.2, 168-173, 2016. (Link to Publication Site) ● Publication site (DOI): 10.1111/cen3.12296 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84961266632 (DOI: 10.1111/cen3.12296, Elsevier: Scopus)
24.	Hiroyuki Nodera, Naoko Takamatsu, Naoko Matsui, Atsuko Mori, Yuka Terasawa, Yoshimitsu Shimatani, Yusuke Osaki, Keiko Maruyama, Yuishin Izumi and Ryuji Kaji : Intramuscular dissociation of echogenicity in the triceps surae characterizes sporadic inclusion body myositis, European Journal of Neurology, Vol.23, No.3, 588-596, 2016. (Summary) Differential diagnosis of sporadic inclusion body myositis (s-IBM) and polymyositis (PM)/dermatomyositis (DM) is difficult and can affect proper disease management. Detection of heterogeneous muscular involvement in s-IBM by muscle sonography could be a unique diagnostic feature. Sonography of the lower leg and forearm was performed in patients with s-IBM, PM/DM and control subjects (n = 11 each). Echo intensities (EIs) of the adjacent muscles [medial head of the gastrocnemius versus soleus and the flexor digitorum profundus (FDP) versus flexor carpi ulnaris (FCU)] were scored by three blinded raters. The mean EIs of these muscles were compared using computer-assisted histogram analysis. Both evaluation methods showed high echoic signals in the gastrocnemius of patients with s-IBM. EIs were significantly different between the gastrocnemius and soleus in patients with s-IBM, but not in those with DM/PM and the controls. In the forearm, although the EI of the FDP was higher in the s-IBM group than in the other groups, the EI differences between the FDP and FCU did not differ significantly between disease groups. The difference in area under the curves to differentiate between s-IBM and DM/PM was greatest between the gastrocnemius-soleus EIs (0.843; P = 0.006). High echoic signals in the medial gastrocnemius compared with those of the soleus are suggestive of s-IBM over PM/DM. (Link to Publication Site) ● Publication site (DOI): 10.1111/ene.12899 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26706399 ● Search Scopus @ Elsevier (PMID): 26706399 ● Search Scopus @ Elsevier (DOI): 10.1111/ene.12899 (DOI: 10.1111/ene.12899, PubMed: 26706399)
25.	Toshitaka Kawarai, Ryosuke Miyamoto, Atsuko Mori, Ryosuke Oki, Ai Tsukamoto-Miyashiro, Naoko Matsui, Yoshimichi Miyazaki, Antonio Orlacchio, Yuishin Izumi, Yoshihiko Nishida and Ryuji Kaji : Late-onset spastic paraplegia: Aberrant SPG11 transcripts generated by a novel splice site donor mutation., Journal of the Neurological Sciences, Vol.359, No.1-2, 250-255, 2015. (Summary) We identified a novel homozygous mutation in the splice site donor (SSD) of intron 30 (c.5866+1G>A) in consanguineous Japanese SPG11 siblings showing late-onset spastic paraplegia using the whole-exome sequencing. Phenotypic variability was observed, including age-at-onset, dysarthria and pes cavus. Coding DNA sequencing revealed that the mutation affected the recognition of the constitutive SSD of intron 30, splicing upstream onto a nearby cryptic SSD in exon 30. The use of constitutive splice sites of intron 29 was confirmed by sequencing. The mutant transcripts are mostly subject to degradation by the nonsense-mediated mRNA decay system. SPG11 transcripts, escaping from the nonsense-mediated mRNA decay pathway, would generate a truncated protein (p.Tyr1900Phefs5X) containing the first 1899 amino acids and followed by 4 aberrant amino acids. This study showed a successful clinical application of whole-exome sequencing in spastic paraplegia and demonstrated a further evidence of allelic heterogeneity in SPG11. The confirmation of aberrant transcript by splice site mutation is a prerequisite for a more precise molecular diagnosis. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jns.2015.10.045 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26671123 ● Search Scopus @ Elsevier (PMID): 26671123 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2015.10.045 (DOI: 10.1016/j.jns.2015.10.045, PubMed: 26671123)
26.	Takahiro Furukawa, Naoko Matsui, Koji Fujita, Hiroyuki Nodera, Fumitaka Shimizu, Katsuichi Miyamoto, Yukitoshi Takahashi, Takashi Kanda, Susumu Kusunoki, Yuishin Izumi and Ryuji Kaji : CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy., Neurology® Neuroimmunology & Neuroinflammation, Vol.2, No.5, e138, 2015. (Summary) The CSF cytokine profile of patients with MMN is distinct from that of patients with PMA and ALS. The similarity of the cytokine profiles between patients with PMA and ALS suggests that PMA shares common immunologic features with ALS in the CNS, even without clinical evidence of upper motor neuron involvement. (Tokushima University Institutional Repository) ● Metadata: 109981 (Link to Publication Site) ● Publication site (DOI): 10.1212/NXI.0000000000000138 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26280014 ● Search Scopus @ Elsevier (PMID): 26280014 ● Search Scopus @ Elsevier (DOI): 10.1212/NXI.0000000000000138 (Tokushima University Institutional Repository: 109981, DOI: 10.1212/NXI.0000000000000138, PubMed: 26280014)
27.	Takahiro Furukawa, Naoko Matsui, Koji Fujita, Ai Miyashiro, Hiroyuki Nodera, Yuishin Izumi, Fumitaka Shimizu, Katsuichi Miyamoto, Yukitoshi Takahashi, Takashi Kanda, Susumu Kusunoki and Ryuji Kaji : Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy., Journal of the Neurological Sciences, Vol.346, No.1-2, 75-79, 2014. (Summary) Proinflammatory cytokines may contribute to peripheral nerve demyelination in MMN. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jns.2014.07.059 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25130929 ● Search Scopus @ Elsevier (PMID): 25130929 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2014.07.059 (DOI: 10.1016/j.jns.2014.07.059, PubMed: 25130929)
28.	酒井和香, Naoko Matsui, Koji Fujita, Yuishin Izumi, 西田喜彦, 高橋利幸, 神林崇 and Ryuji Kaji : Case of neuromyelitis optica spectrum disorder associated with central pontine and extrapontine myelinolysis preceded by syndrome of inappropriate antidiuretic hormone secretion, Clinical Neurology, Vol.54, No.7, 556-560, 2014. (Summary) A 36-year-old woman complained of general malaise. She presented with hyponatremia and plasma osmotic pressure was lower than urinary osmotic pressure. In addition, serum antidiuretic hormone level was higher than the measurement sensitivity. She was diagnosed with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). She fell into a coma despite correction of serum sodium level. Brain magnetic resonance imaging (MRI) revealed high signal intensities in the cerebral cortex, striatum, thalamus, hypothalamus, midbrain, and pons in fluid-attenuated inversion recovery images. Spinal MRI revealed a longitudinally extending lesion in the cervical cord. Serum sample was positive for anti-aquaporin-4 antibody, supporting the diagnosis of neuromyelitis optica spectrum disorder (NMOSD) combined with central pontine and extrapontine myelinolysis. In patients with NMOSD, the immune reaction can gradually cause destructive changes of the hypothalamus and lead to unstable ADH secretion in the absence of immunomodulatory treatment. (Keyword) Adult / Aquaporin 4 / Biomarkers / Brain / Humans / Inappropriate ADH Syndrome / Magnetic Resonance Imaging / Male / Methylprednisolone / Myelinolysis, Central Pontine / Neuromyelitis Optica / Plasma Exchange / Prednisolone / Pulse Therapy, Drug / Sodium / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.5692/clinicalneurol.54.556 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25087556 ● Summary page in Scopus @ Elsevier: 2-s2.0-84906089774 (DOI: 10.5692/clinicalneurol.54.556, PubMed: 25087556, Elsevier: Scopus)
29.	Fumitaka Shimizu, Masatoshi Omoto, Yasuteru Sano, Naoko Matsui, Ai Miyashiro, Ayako Tasaki, Toshihiko Maeda, Michiaki Koga, Ryuji Kaji and Takashi Kanda : Sera from patients with multifocal motor neuropathy disrupt the blood-nerve barrier, Journal of Neurology, Neurosurgery, and Psychiatry, Vol.85, No.5, 526-537, 2014. (Summary) In multifocal motor neuropathy (MMN), the destruction of the blood-nerve barrier (BNB) has been considered to be the key step in the disease process. The purpose of the present study was to ascertain whether sera from patients with MMN can open the BNB, and which component of patient sera is the most important for this disruption. We evaluated the effects of sera from patients with MMN, patients with amyotrophic lateral sclerosis, and control subjects on the expression of tight junction proteins and vascular cell adhesion molecule-1 (VCAM-1), and on the transendothelial electrical resistance (TEER) in human peripheral nerve microvascular endothelial cells (PnMECs). The sera from patients with MMN decreased the claudin-5 protein expression and the TEER in PnMECs. However, this effect was reversed after application of an anti-vascular endothelial growth factor (anti-VEGF) neutralising antibody. The VEGF secreted by PnMECs was significantly increased after exposure to the sera from patients with MMN. The sera from patients with MMN also increased the VCAM-1 protein expression by upregulating the nuclear factor kappa-B (NF-κB) signalling. The immunoglobulin G purified from MMN sera decreased the expression of claudin-5 and increased the VCAM-1 expression in PnMECs. The sera from MMN patients may disrupt the BNB function via the autocrine secretion of VEGF in PnMECs, or the exposure to autoantibodies against PnMECs that are contained in the MMN sera. Autoantibodies against PnMECs in MMN sera may activate the BNB by upregulating the VCAM-1 expression, thereby allowing for the entry of a large number of circulating inflammatory cells into the peripheral nervous system. (Keyword) Adolescent / Adult / Amyotrophic Lateral Sclerosis / Blood-Nerve Barrier / Case-Control Studies / Cell Culture Techniques / Electric Impedance / Endothelial Cells / Female / Humans / Male / Middle Aged / Polyneuropathies / Serum / Tight Junctions / Vascular Cell Adhesion Molecule-1 / Young Adult (Link to Publication Site) ● Publication site (DOI): 10.1136/jnnp-2013-305405 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23926278 ● Summary page in Scopus @ Elsevier: 2-s2.0-84898925618 (DOI: 10.1136/jnnp-2013-305405, PubMed: 23926278, Elsevier: Scopus)
30.	Ai Miyashiro, Naoko Matsui, Yoshimitsu Shimatani, Hiroyuki Nodera, Yuishin Izumi, Satoshi Kawabata, Tomihiro Imai, Masayuki Baba, Tetsuo Komori, Masahiro Sonoo, Takahiro Maezaki, Jun Kawamata, Takefumi Hitomi, Nobuo Kohara, Kimiyoshi Arimura, Shuji Hashimoto, Kokichi Arisawa, Susumu Kusunoki and Ryuji Kaji : Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan, Muscle & Nerve, Vol.49, No.3, 357-361, 2014. (Summary) Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers. (Keyword) Adolescent / Adult / Aged / Aged, 80 and over / Amyotrophic Lateral Sclerosis / Evoked Potentials, Motor / Female / Hospitals / Humans / Japan / Male / Middle Aged / Peripheral Nervous System Diseases / Retrospective Studies / Young Adult (Tokushima University Institutional Repository) ● Metadata: 105906 (Link to Publication Site) ● Publication site (DOI): 10.1002/mus.23930 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24741683 ● Summary page in Scopus @ Elsevier: 2-s2.0-84893935930 (Tokushima University Institutional Repository: 105906, DOI: 10.1002/mus.23930, PubMed: 24741683, Elsevier: Scopus)
31.	Mungunkhuyag Majigusuren, Masafumi Harada, Takashi Abe, Koji Fujita, Naoko Matsui and Ryuji Kaji : Longitudinal Monitoring with Multiple MR Techniques in a Case of Progressive Multifocal Leukoencephalopathy Associated with Multiple Myeloma, Magnetic Resonance in Medical Sciences, Vol.13, No.1, 55-59, 2014. (Summary) Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by the JC virus in immunocompromised patients. We report characteristic features of proton MR spectroscopy, 3-dimensional pseudo-continuous arterial spin labeling imaging, and diffusion tensor imaging in a 53-year-old patient with PML. The utility of multi-modal magnetic resonance techniques for longitudinal monitoring was indicated by their reevaluation over time and consideration of their relation to prognosis. (Keyword) Disease Progression / Humans / Leukoencephalopathy, Progressive Multifocal / Magnetic Resonance Imaging / Male / Middle Aged / Multiple Myeloma (Link to Publication Site) ● Publication site (DOI): 10.2463/mrms.2013-0037 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24492738 ● Summary page in Scopus @ Elsevier: 2-s2.0-84897898031 (DOI: 10.2463/mrms.2013-0037, PubMed: 24492738, Elsevier: Scopus)
32.	Naoko Matsui, Izumi Ohigashi, Keijirou Tanaka, Mie Sakata, Takahiro Furukawa, Yasushi Nakagawa, Kazuya Kondo, Tetsuya Kitagawa, Sumimasa Yamashita, Yoshiko Nomura, Yousuke Takahama and Ryuji Kaji : Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia., Journal of Neuroimmunology, Vol.269, No.1-2, 56-61, 2014. (Summary) The thymus is implicated as an organ that contributes to autoimmunity in myasthenia gravis (MG) patients. Hassall's corpuscles (HCs) are assumed to represent the terminally differentiated stage of medullary thymic epithelial cells (mTECs). By using multicolor immunohistofluorescence analysis, we examined HCs in thymuses that were therapeutically excised from MG (+) and MG (-) patients. We found that the number of HCs per unit area of the thymic medulla was significantly elevated in the thymuses of MG (+) patients with thymic hyperplasia. CCL21 expression increased in the hyperplastic MG thymuses. We speculate that the altered differentiation of mTECs is associated with the thymic hyperplasia and the onset of MG. (Keyword) Adult / Aged / Cell Count / Cell Differentiation / Chemokine CCL21 / Epithelial Cells / Female / Humans / Infant / Male / Middle Aged / Myasthenia Gravis / Thymus Hyperplasia (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jneuroim.2014.01.011 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24556356 ● Summary page in Scopus @ Elsevier: 2-s2.0-84896393117 (DOI: 10.1016/j.jneuroim.2014.01.011, PubMed: 24556356, Elsevier: Scopus)
33.	Takao Mitsui, Yukiko Kuroda, Shu-ichi Ueono, Naoko Matsui and Ryuji Kaji : FK506 attenuates thymic output in patients with myasthenia gravis, Archives of Medical Science : AMS, Vol.9, No.6, 1090-1096, 2013. (Summary) Myasthenia gravis (MG) is an antibody-mediated, T-cell-dependent autoimmune disease. The symptoms are caused by high-affinity IgG against the muscle acetylcholine receptor (AChR) at the neuromuscular junction. The production of these antibodies in B-cells depends on AChR-specific CD4(+) T-cells and the thymus gland seems to play a significant role in the pathogenesis of MG. Altered thymic T-cell export seems to be associated with a pathological mechanism in myasthenia gravis. Tacrolimus (FK506) has recently been used to treat MG. We examined the effects of tacrolimus on thymic T-cell export in patients with MG. Sixteen patients with nonthymomatous and/or thymectomized MG were treated with oral administrations of tacrolimus. To assess the effect of tacrolimus on the thymic output, we assayed the levels of T-cell receptor excision circle (TREC), a molecular marker of thymus emigrants. T-cell receptor excision circle was not significantly different from those in age-matched controls before tacrolimus therapy, but they were partially decreased 4 months after tacrolimus therapy. T-cell receptor excision circle levels were significantly decreased in the thymomatous group (p < 0.05), but not in the nonthymomatous group. Tacrolimus treatment significantly attenuated TREC levels in cultured CD4(-)CD8(+) cells (p < 0.05), but total cell counts were not significantly changed. These results indicate that TREC levels may become a marker of the curative effect of tacrolimus therapy for thymomatous MG, and that tacrolimus suppresses not only activating T-lymphocytes, but also naïve T-cells. (Link to Publication Site) ● Publication site (DOI): 10.5114/aoms.2013.39797 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24482655 ● Search Scopus @ Elsevier (PMID): 24482655 ● Search Scopus @ Elsevier (DOI): 10.5114/aoms.2013.39797 (DOI: 10.5114/aoms.2013.39797, PubMed: 24482655)
34.	Koji Fujita, Naoko Matsui, Yukitoshi Takahashi, Yasushi Iwasaki, Mari Yoshida, Tatsuhiko Yuasa, Yuishin Izumi and Ryuji Kaji : Increased interleukin-17 in the cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease: a case-control study of rapidly progressive dementia, Journal of Neuroinflammation, Vol.10, 135, 2013. (Summary) Inflammatory responses in the cerebrospinal fluid (CSF) of patients with sporadic Creutzfeldt-Jakob disease (sCJD) remain elusive. We conducted a case-control study, in which 14 patients with sCJD, 14 with noninflammatory neurological disorders, and 14 with autoimmune encephalitis were enrolled. We used the suspension array system to measure the concentrations of 27 cytokines in CSF. The cytokine titers of the three groups were compared, and the correlation between the relevant cytokine titers and clinical parameters was investigated in the patients with sCJD. Levels of the two cytokines interleukin (IL)-1 receptor antagonist and IL-17 were significantly elevated in the patients with sCJD compared with those in the patients with noninflammatory neurological disorders: IL-17 levels in sCJD were approximately ten times higher than in the noninflammatory neurological disorders (mean, 35.46 vs. 3.45 pg/ml; P < 0.001) but comparable to that in encephalitis (mean, 32.16 pg/ml). In contrast, levels of classical proinflammatory cytokines such as IL-12(p70) and tumor necrosis factor-α were increased only in encephalitis. Although not significant, IL-17 titers tended to be higher in the patients with shorter disease duration before CSF sampling (r = -0.452; P = 0.104) and in those with lower CSF total protein concentrations (r = -0.473; P = 0.086). IL-17 is significantly increased in CSF in sCJD, which can be an early event in the pathogenesis of sCJD. (Keyword) Aged / Case-Control Studies / Creutzfeldt-Jakob Syndrome / Dementia / Disease Progression / Female / Humans / Interleukin-17 / Male (Link to Publication Site) ● Publication site (DOI): 10.1186/1742-2094-10-135 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24219883 ● Search Scopus @ Elsevier (PMID): 24219883 ● Search Scopus @ Elsevier (DOI): 10.1186/1742-2094-10-135 (DOI: 10.1186/1742-2094-10-135, PubMed: 24219883)
35.	Syunya Nakane, Koji Fujita, Yoshiko Shibuta, Naoko Matsui, Masafumi Harada, Ryo Urushihara, Yoshihiko Nishida, Yuishin Izumi and Ryuji Kaji : Successful treatment of stiff person syndrome with sequential use of tacrolimus, Journal of Neurology, Neurosurgery, and Psychiatry, Vol.84, No.10, 1177-1180, 2013. (Keyword) Aged / Autoantibodies / Brain / Dose-Response Relationship, Drug / Drug Administration Schedule / Evoked Potentials, Motor / Female / Follow-Up Studies / Glutamate Decarboxylase / Humans / Immunosuppressive Agents / Magnetic Resonance Spectroscopy / Male / Middle Aged / Motor Cortex / Neurologic Examination / Stiff-Person Syndrome / Tacrolimus / Transcranial Magnetic Stimulation / gamma-Aminobutyric Acid (Link to Publication Site) ● Publication site (DOI): 10.1136/jnnp-2013-305425 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23715915 ● Search Scopus @ Elsevier (PMID): 23715915 ● Search Scopus @ Elsevier (DOI): 10.1136/jnnp-2013-305425 (DOI: 10.1136/jnnp-2013-305425, PubMed: 23715915)
36.	Naoko Matsui, Ai Miyashiro, Yoshimitsu Shimatani, Hiroyuki Nodera, Yuishin Izumi, Satoshi Kuwabara, Masayuki Baba, Tetsuo Komori, Masahiro Sonoo, Takahiro Mezaki, Jun Kawamata, Takefumi Hitomi, Tomihiro Imai, Nobuo Kohara, Kimiyoshi Arimura, Kokichi Arisawa, Susumu Kusunoki and Ryuji Kaji : Diagnostic spectrum of multifocal motor neuropathy, Clinical & Experimental Neuroimmunology, Vol.4, No.2, 210-215, 2013. (Link to Publication Site) ● Publication site (DOI): 10.1111/cen3.12025 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1111/cen3.12025 (DOI: 10.1111/cen3.12025)
37.	Yoshimichi Miyazaki, 高松直子, Ai Miyashiro, Yuka Terasawa, Naoko Matsui, Koutaro Asanuma, Yuishin Izumi and Ryuji Kaji : A case of enlargement of the right atrium associated with myositis detected by muscle ultrasonography, Neurosonology, Vol.24, No.1, 12-14, 2011. (Summary) A 45-year-old woman was admitted to the hospital because of general malaise since 2005. She have not remarkable disease in the past history. In the family history, one of her older sister died of ulcerative colitis, another one suffers from systemic lupus erythematosis, and her older brother affected of Behçet's disease. On electrocardiogram examination, atrial fibrillation was revealed associated with remarkable dilation of the right atrium in echocardiogram, but any abnormal finding is not seen both ventricles. The ultrasonographic findings of the biceps brachi showed remarkable myopathic pattern. A biopsy specimen obtained from the biceps brachi, these muscles revealed degeneration and necrosis of muscle fibers, interstitial infiltration with monocytes, and perivascular infiltrates of inflammatory cells. In the magnetic resonance imaging of the heart showed, not only remarkable dilatation of right atria, but also diffuse high intensity areas in left ventricle under T2-intensified conditions. We diagnosed generalized myositis involved with myocarditis, and treated with steroid. One year later, she still takes steroid, and her symptoms improvement continuously.If one of cardiac atrium or ventricle enlarged, there is possibility of the cardiac myositis or systemic myositis. In these cases, skeletal muscle ultrasonography may be non-invasive and useful method of differential diagnosis. (Keyword) Methylprednisolone(治療的利用) 病的拡張症(病因,超音波診断,薬物療法) 筋炎(合併症,超音波診断,薬物療法) 超音波診断パルス療法(薬物療法) 心房拡張(病因,超音波診断,薬物療法) ヒト中年(45~64) 女 (Link to Publication Site) ● Publication site (DOI): 10.2301/neurosonology.24.12 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679397005184 ● Search Scopus @ Elsevier (DOI): 10.2301/neurosonology.24.12 (DOI: 10.2301/neurosonology.24.12, CiNii: 1390282679397005184)
38.	Yamanaka Chihiro, Mariko Egawa, Yoshinori Mitamura, Naoko Matsui and Ryuji Kaji : Clinical features of optic neuritis positive for anti-aquaporin 4 antibody, Japanese Journal of Clinical Ophthalmology, Vol.65, No.4, 521-526, 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521417755902852864 ● Summary page in Scopus @ Elsevier: 2-s2.0-79955804438 (CiNii: 1521417755902852864, Elsevier: Scopus)
39.	Naoko Matsui, Shunya Nakane, Fumi Saitou, Izumi Ohigashi, Yasushi Nakagawa, Hirotsugu Kurobe, Hiromitsu Takizawa, Takao Mitsui, Kazuya Kondo, Tetsuya Kitagawa, Yousuke Takahama and Ryuji Kaji : Undiminished regulatory T cells in the thymus of myathenia gravis patients, Neurology, Vol.74, No.10, 816-820, 2010. (Summary) The thymus has been implicated as a possible site of origin that triggers autoimmunity in myasthenia gravis (MG). Although several groups have suggested that the decrease in the number of regulatory T (Treg) cells contributes to the onset of MG, the exact role of Treg cells in MG remains unclear. To address this point, we examined the number and distribution of Treg cells in a large number of patients with MG. Immunohistofluorescence analysis of Foxp3 along with CD4 and CD8 was performed in thymic sections of MG (+) (n = 24) and MG (-) patients (n = 27). Circulating CD4(+)CD25(+) cells in the peripheral blood of patients with MG (n = 15) and age-matched healthy subjects (n = 15) were also analyzed. Foxp3(+)CD4(+)CD8(-) cells were predominantly found in the thymic medulla and their number declined with age. There was no significant difference in the number or the distribution of Foxp3(+)CD4(+)CD8(-) cells in the thymus between MG (+) and MG (-) patients. The number of circulating CD4(+)CD25(+) cells in the peripheral blood of patients with MG was not significantly altered compared to that in healthy subjects. The cellularity of Treg cells in the thymus and circulation is not diminished in patients with myasthenia gravis. (Keyword) Age Factors / Antigens, CD / Cell Count / Female / Flow Cytometry / Forkhead Transcription Factors / Humans / Male / Myasthenia Gravis / T-Lymphocytes, Regulatory / Thymus Gland (Link to Publication Site) ● Publication site (DOI): 10.1212/WNL.0b013e3181d31e47 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20211905 ● Search Scopus @ Elsevier (PMID): 20211905 ● Search Scopus @ Elsevier (DOI): 10.1212/WNL.0b013e3181d31e47 (DOI: 10.1212/WNL.0b013e3181d31e47, PubMed: 20211905)
40.	Naoko Matsui, Yuishin Izumi, Hiroyuki Azuma and Ryuji Kaji : Neurological manifestations in hereditary hemorrhagic telangiectasia type 1: a familial case in Japan, Journal of Tokushima National Hospital, Vol.2010, No.1, 11-14, 2010. (Keyword) Hereditary hemorrhagic telangiectasia (HHT) / HHT type 1 (HHT1) / endoglin / pulmonary arteriovenous malformations (PAVMs) / cerebroarteriovenous malformations (CAVMs) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1523106605998613120 (CiNii: 1523106605998613120)
41.	Yoshimichi Miyazaki, Ai Miyashiro, Yoshimitsu Simatani, Naoko Matsui, Koutaro Asanuma, Yuishin Izumi and Ryuji Kaji : A case of cryptococcal meningitis successfully treated with liposomal amphotericin-B, Fulcytosine, and Voriconazole, Journal of Tokushima National Hospital, Vol.1, 31-34, 2010. (Summary) クリプトコッカス性髄膜炎の59歳男性症例について検討した．発熱と頭痛を主訴とし，風邪と診断さたが，嘔吐，意識障害，歩行困難の症状が出現し，発症から16日目に入院となった．入院時に意識障害と強い傾眠傾向が認められた．右眼の対光反射が鈍く，瞳孔径の左右差が認められた．顕著な頸部硬直も認められた．ウイルス関連抗原抗体は陰性であった．脳脊髄液はキサントクロミーを呈しており，脳脊髄液圧，脳脊髄液中の細胞数と蛋白濃度の上昇，脳脊髄液中の糖濃度低下が認められた．May-Giemsa染色および墨汁染色では莢膜を有する菌体が多数確認された．Cryptococcus抗原の256倍上昇が示された．頭部のガドリニウム造影MRI検査で脳溝に沿った造影像を認めた．クリプトコッカス性髄膜炎と診断し，liposomal amphotericin-Bおよびfulcytosineによる2剤療法を開始した．臨床検査結果および脳脊髄液検査結果は徐々に改善したが，入院45日目に左顔面麻痺が出現した．MRI検査から新しい病変が確認され，造影MRI検査で造影病変の拡大を認めた．Voriconazole追加による3剤療法を開始した．脳脊髄液検査結果および臨床症状の改善を示し，入院180日目に退院となった．左顔面麻痺も徐々に改善した． (Keyword) Amphotericin B(治療的利用,毒性・副作用) Flucytosine(治療的利用) Gadolinium(診断的利用) 真菌抗原(血液) MRI 多剤併用療法低カリウム血症(化学的誘発) 髄液髄膜炎-クリプトコッカス(薬物療法) Voriconazole(治療的利用) 髄液検査ヒト中年(45~64) 男 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1523951030929400320 (CiNii: 1523951030929400320)
42.	Naoko Matsui, Shunya Nakane, Yuishin Izumi, Shinji Nagahiro, 西田善彦 and Ryuji Kaji : 健常者に発症し治療に難渋したクリプトコッカス髄膜脳炎の1例, Neurological Therapeutics, Vol.24, 497-502, 2007.
43.	Naoko Matsui, Takao Mitsui, Itsuro Endo, Yasushi Oshima, Makoto Kunishige and Toshio Matsumoto : Dermatomyositis with peripheral nervous system involvement: activation of vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) in vasculitic lesions, Internal Medicine, Vol.42, No.12, 1233-1239, 2003. (Summary) We describe two cases of dermatomyositis (DM) with nervous system involvement. Polyneuropathy was observed in both patients, and cerebral vasculitis was suspected in one patient. Histological examination of biopsied specimens of skeletal muscles, skin and sural nerves revealed vasculitis. Furthermore, vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) were overexpressed in vasculitic lesions. Although, VEGF and VEGFRs were not detected in biopsied specimens of skeletal muscle from normal subjects, they were observed in one of two patients with DM who did not exhibit neuropathy. These findings suggest the possibility that VEGF overproduction is associated with development of vasculitis in some cases of DM complicated with peripheral neuropathy. (Keyword) DErmatomyositis / VEGF (Link to Publication Site) ● Publication site (DOI): 10.2169/internalmedicine.42.1233 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14714966 ● Search Scopus @ Elsevier (PMID): 14714966 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.42.1233 (DOI: 10.2169/internalmedicine.42.1233, PubMed: 14714966)

Academic Paper (Unrefereed Paper):

1.	細川忍, 戸根沙織, Naoko Matsui, Kenya Kusunose, Kumiko Kagawa, 山上圭, 廣島裕也 and 田村洋人 : 症例検討:妊婦に発症した脳梗塞の1例, The Journal of the Japanese Society of Internal Medicine, Vol.106, No.10, 2265-2272, 2017. (Link to Publication Site) ● Publication site (DOI): 10.2169/naika.106.2265 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.2169/naika.106.2265 (DOI: 10.2169/naika.106.2265)
2.	Yoshimichi Miyazaki, Naoko Matsui, Koji Fujita, Takashi Abe, 高橋利幸 and Masafumi Harada : 脳室周囲および延髄背側の病変, Practical Currently, Vol.24, No.10, 1100-1105, 2014.
3.	Naoko Matsui, Takao Mitsui, Yasushi Ohshima, Kenji Yokoi, Makoto Kunishige, Fumikazu Yagi, Steven Vernino, Toshio Matsumoto and Ryuji Kaji : Anti-neuronal antibodies in acute pandysautonomia., Internal Medicine, Vol.49, No.1, 73-77, 2010. (Summary) We encountered two patients with acute pandysautonomia who subacutely exhibited extensive autonomic dysfunction after antecedent infections. Although these patients had been suffering from autonomic disturbance for several months, they both had a good clinical course after plasma exchange and intravenous immunoglobulin therapy. Thin-layer chromatography (TLC)-immunostaining did not demonstrate any antibodies against gangliosides, but immunoblot analysis showed antibodies against a neuroblastoma cell line, SH-SY5Y, in serum samples. Furthermore, ganglionic acetylcholine receptor autoantibodies were detected in one patient. These findings suggest that neuronal antibodies against the autonomic nervous system play an important role in the pathogenesis of acute pandysautonomia. (Keyword) Aged / Autoantibodies / Autoimmune Diseases of the Nervous System / Autonomic Nervous System Diseases / Humans / Immunoblotting / Immunoglobulins, Intravenous / Male / Neurons / Plasma Exchange / Receptors, Cholinergic (Link to Publication Site) ● Publication site (DOI): 10.2169/internalmedicine.49.2788 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20046006 ● CiNii @ National Institute of Informatics (CRID): 1390001204871227136 ● Search Scopus @ Elsevier (PMID): 20046006 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.49.2788 (DOI: 10.2169/internalmedicine.49.2788, PubMed: 20046006, CiNii: 1390001204871227136)

Review, Commentary:

1.	Naoko Matsui : T細胞によるMGの病態, Clinical Neuroscience, Vol.41, 1475-1478, Nov. 2023.
2.	Naoko Matsui, Izumi Ohigashi and Yuishin Izumi : 重症筋無力症と胸腺摘出, 脳神経内科, Vol.98, No.6, 823-828, Jun. 2023.
3.	Naoko Matsui, 田中恵子 and Yuishin Izumi : スティッフパーソン症候群, Brain and Nerve = Shinkei kenkyū no shinpo, Vol.75, No.6, 749-754, Jun. 2023. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520578282911297280 (CiNii: 1520578282911297280)
4.	Naoko Matsui and Yuishin Izumi : 多巣性運動ニューロパチー(MMN), 最新ガイドラインに基づく神経疾患診療指針, 337-340, May 2023.
5.	Naoko Matsui : 抑制性シナプスに対する自己免疫疾患, 自己免疫性脳炎・関連疾患ハンドブック, 187-194, May 2023.
6.	Naoko Matsui, 田中恵子 and Yuishin Izumi : Stiff-person syndrome, Progressive encephalomyelitis with rigidity and myoclonus, 免疫性神経疾患(第2版), Vol.80, No.5, 355-360, May 2022.
7.	Naoko Matsui : 多巣性運動ニューロパチー(MMN), 今日の治療指針, 977, Jan. 2019.
8.	石田光代, Naoko Matsui, 高橋美和, 杉原治美, Yuishin Izumi, 西田善彦 and Ryuji Kaji : 就労可能な神経難病患者における共通特性の検討, 日本難病医療ネットワーク学会機関誌, Vol.5, No.2, 50-55, Nov. 2018.
9.	Naoko Matsui, Yohhei Yamamoto and Ryuji Kaji : 多巣性運動ニューロパチー (MMN), Clinical Neuroscience, Vol.36, No.9, 1051-1053, Sep. 2018.
10.	Yohhei Yamamoto, Naoko Matsui and Ryuji Kaji : 多巣性運動ニューロパチー(MMN)の病態と治療, Peripheral Nerve 末梢神経, Vol.29, No.1, 24-27, Jun. 2018.
11.	Naoko Matsui, 田中惠子 and Ryuji Kaji : ステイッフ・パーソン症候群と自己抗体, Brain and Nerve = Shinkei kenkyū no shinpo, Vol.70, No.4, 357-362, Apr. 2018. (Link to Publication Site) ● Publication site (DOI): 10.11477/mf.1416201008 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1416201008 (DOI: 10.11477/mf.1416201008)
12.	Naoko Matsui, Shunya Nakane and Ryuji Kaji : ステイッフパーソン症候群, Modern Physician, Vol.36, No.7, 745-747, Jul. 2016.
13.	Naoko Matsui, Ai Miyashiro and 古川貴大 : 多巣性運動ニューロパチー(MMN)の疫学・症状と神経症候・発症機序, Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.73, No.7, 422-426, Sep. 2015.
14.	Naoko Matsui and Ryuji Kaji : 慢性炎症性脱髄性多発根ニューロパチー，多巣性運動ニューロパチー診療ガイドライン2013の要点, Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.73, No.7, 419-421, Sep. 2015.
15.	山口普史, Hiroshi Bandou, 新谷保実, Hiroaki Yanagawa, Naoko Matsui, 重清俊雄, 田邊舞, 高岡奨, 飯間努, Masahiro Oura, 喜多秀仁, 戸根沙織, 野田和克 and 森住俊 : 意識障害患者の鑑別診断における詳細な病歴確認の重要性, 日本内科学会雑誌, Vol.104, No.7, 1495-1503, Jul. 2015.
16.	山口普史, Hiroshi Bandou, 新谷保実, Hiroaki Yanagawa, Naoko Matsui, 重清俊雄, 田邊舞, 高岡奨, 飯間努, 大浦雅博, 喜多秀仁, 戸根沙織, 野田和克 and 森住俊 : 意識障害患者の鑑別診断における詳細な病歴確認の重要性, 日本内科学会雑誌, Vol.104, No.7, 1495-1503, Jul. 2015.
17.	Naoko Matsui : 三叉神経痛, 歯科展望別冊・歯科医師のための医学ハンドブック, 114, May 2014.
18.	Naoko Matsui : 筋ジストロフィー・重症筋無力症, 歯科展望別冊・歯科医師のための医学ハンドブック, 113, May 2014.
19.	古川貴大, Naoko Matsui and Ryuji Kaji : 多巣性運動ニューロパチー(MMN), 別冊日本臨床領域別症候群27 神経症候群, 848-850, Mar. 2014.
20.	Naoko Matsui, 古川貴大 and Ryuji Kaji : 多巣性運動ニューロパチー(MMN) 病態と検査所見, Clinical Neuroscience, Vol.32, No.3, 324-326, Mar. 2014.
21.	Naoko Matsui : 多巣性運動ニューロパチー, 今日の治療指針, 885-886, 2014.
22.	Yoshimichi Miyazaki, Naoko Matsui, Koji Fujita, Takashi Abe, 高橋利幸, Masafumi Harada and Ryuji Kaji : 見逃し危険!MRIで迫る中枢神経疾患の画像診断(第8回) 脳室周囲および延髄背側の病変心因性障害と考えられていた39歳女性, Practical Currently, Vol.24, No.10, 1094-1099, 2014. (Summary) <Key Points>(1)視神経炎や脊髄炎を呈し，脳室周囲や延髄背側の病変，3椎体以上の長い脊髄病変を見たときはNMO spectrum disorderを疑い，抗AQP4抗体を検査する．(2)NMO spectrum disorderの急性期はステロイドパルスや血漿交換を行い，再発予防はプレドニゾロンが第一選択である．(著者抄録) (Keyword) Prednisolone(治療的利用) 延髄(画像診断) 血漿交換 MRI 視神経脊髄炎(画像診断,薬物療法,治療) 鑑別診断多発性硬化症脳室(画像診断) 心因性疾患ヒト成人(19~44) 女
23.	Naoko Matsui and Ryuji Kaji : MMN:疫学と治療の実態, BRAIN MEDICAL, Vol.25, No.3, 45-48, Dec. 2013.
24.	Naoko Matsui, Ai Miyashiro and Ryuji Kaji : 多巣性運動ニューロパチー(MMN)の疫学・病態と治療, 特集:免疫性神経疾患, Vol.71, No.5, 861-864, May 2013.
25.	Naoko Matsui : Multifocal motor neuropathy: Current review of epidemiology and treatment, Clinical Neurology, Vol.52, No.11, 920-922, 2012. (Summary) The diagnosis of multifocal motor neuropathy (MMN) is often missed because MMN disguises itself as a motor neuron disease and is considered relatively rare. Detailed epidemiological studies of MMN have not been undertaken. We therefore conducted a nationwide survey of MMN in comparison with amyotrophic lateral sclerosis (ALS). This retrospective study examined 47 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. MMN had a younger age of onset and was more common in males than ALS. The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.3 cases for MMN and 6.63 cases for ALS per 100,000 persons. Twenty-five MMN patients (54.2%) showed conduction block. Thirty-four (75%) of 45 MMN patients received intravenous immunoglobulin exhibited a favorable outcome. It is expected that more sensitive indicators of conduction block or focal demyelinating lesions than currently available MMN diagnostic criteria would further increase the ratio of MMN to ALS patients and the total number of MMN patients who can benefit from treatment. MMN is by no means a rare disorder but should be accurately diagnosed in all neuromuscular centers.<br> (Keyword) multifocal motor neuropathy / amyotrophic lateral sclerosis / nationwide survey / conduction block / intravenous immunoglobulin (Link to Publication Site) ● Publication site (DOI): 10.5692/clinicalneurol.52.920 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205036619008 ● Search Scopus @ Elsevier (DOI): 10.5692/clinicalneurol.52.920 (DOI: 10.5692/clinicalneurol.52.920, CiNii: 1390001205036619008)
26.	Naoko Matsui, Takeshi Nitta and Yousuke Takahama : Development of the thymus and immune system, Brain and Nerve = Shinkei kenkyū no shinpo, Vol.63, No.7, 679-684, Jul. 2011. (Summary) A repertoire of T cells is primarily formed in the thymus through positive and negative selection of developing thymocytes. The medullary region of the thymus provides a microenvironment that is essential for the establishment of self-tolerance via the depletion of self-reactive T cells and the production of regulatory T cells. Within the medullary microenvironment, medullary thymic epithelial cells play a pivotal role in the establishment of self-tolerance, via the promiscuous expression of tissue-restricted self-antigens and the chemokine-mediated attraction of positively selected T cells from the cortex to the medulla. Positive selection also induces the expression of TNF-superfamily cytokines and thereby nurtures the growth and development of medullary thymic epithelial cells. We will review the mechanisms of how the thymus contributes to the development and selection of T cells, with emphasis on the establishment of self-tolerance in the thymic medulla. (Keyword) T cell repertoire / self-tolerance / thymic microenvironment / medullary thymic epithelial cells / regulatory T cells (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21747137 ● CiNii @ National Institute of Informatics (CRID): 1390002209990745472 ● Summary page in Scopus @ Elsevier: 2-s2.0-79960715822 (PubMed: 21747137, CiNii: 1390002209990745472, Elsevier: Scopus)
27.	宮崎由道, 高松直子, 宮城愛, Yuka Terasawa, Naoko Matsui, Koutaro Asanuma, Yuishin Izumi and Ryuji Kaji : 筋エコーにより筋炎の関与が判明した右房拡張症の一例, Neurosonology, Vol.23, 106, Apr. 2010. (Keyword) 筋炎(合併症,超音波診断); 心筋炎(合併症,超音波診断); 超音波診断; *心房(超音波診断) / ヒト; 中年(45∼64); 女
28.	Naoko Matsui and Yousuke Takahama : 神経系免疫の特徴, Clinical Neuroscience, Vol.28, No.2, 142-145, Feb. 2010.
29.	Naoko Matsui and Yousuke Takahama : 免疫学の基礎:神経系免疫の特徴, Clinical Neuroscience, Vol.28, 142-145, 2010.

Proceeding of International Conference:

1.	Naoko Matsui, Tanaka Keiko, Yamamoto Yohei, Saika Reiko, Iizuka Takahiro, Matsui Makoto, Kokichi Arisawa, Ryuji Kaji, Kuwabara Satoshi and Yuishin Izumi : Prevalence, clinical profiles, and prognosis of Stiff-person syndrome in Japanese nationwide survey, The 9th Congress of the European Academy of Neurology (EAN), Jul. 2023.
2.	Naoko Matsui : Recent advances in neuroimmunological diseases, 14th International Symposium on Nanomedicine (ISNM2021) on joint with 11th Taiwan-Japan-Korea Nanomedicine Meeting, Online, Nov. 2021.
3.	Naoko Matsui, Takahiro Furukawa, Sakai Waka and Ryuji Kaji : Late-onset myasthenia gravis is predisposed to become generalized in the elderly, BITs 7th World Gene Convention, Shanghai, Nov. 2016. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ensci.2016.02.004 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84961639785 (DOI: 10.1016/j.ensci.2016.02.004, Elsevier: Scopus)
4.	Naoko Matsui, Takahiro Furukawa, Koji Fujita, Hiroyuki Nodera, Fumitaka Shimizu, Katsuichi Miyamoto, Yukitoshi Takahashi, Takashi Kanda, Susumu Kusunoki, Yuishin Izumi and Ryuji Kaji : CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy, 1st Asia-Pacific School of Neuroimmunology, Vol.2, No.5, e138, Tokyo, Aug. 2015. (Link to Publication Site) ● Publication site (DOI): 10.1212/NXI.0000000000000138 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85011964802 (DOI: 10.1212/NXI.0000000000000138, Elsevier: Scopus)
5.	Takahiro Furukawa, Naoko Matsui, Kaji Fujita, Hiroyuki Nodera, Fumitaka Shimizu, Katsuyuki Miyamoto, Yukitoshi Takahashi, Takashi Kanda, Susumu Kusunoki, Yuishin Izumi and Ryuji Kaji : CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy, 1st Congress of the European Academy of Neurology, Vol.2, No.5, 138, Berlin, Jul. 2015. (Link to Publication Site) ● Publication site (DOI): 10.1212/NXI.0000000000000138 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85011964802 (DOI: 10.1212/NXI.0000000000000138, Elsevier: Scopus)
6.	Rie Mukai, Naoko Matsui, Takeshi Nikawa and Junji Terao : Dietary quercetin prevents disuse muscle atrophy of denervated mice through regulation of mitochondrial biogenesis, 12th Asian congress of Nutrition, Yokohama, May 2015.
7.	Takashi Abe, Toshitaka Kawarai, Obama Y, Irahara I, Kaji Seiji, Ryosuke Miyamoto, Sakai Waka, Tsukamoto-Miyashiro Ai, Naoko Matsui, Yuishin Izumi, Ryuji Kaji and Masafumi Harada : Retrospective review of MRI and MRS findings in hereditary diffuse leukoencephalopathy with spheroids and elderly asymptomatic carrier of causative gene, colony stimulating factor-1 receptor: a single institution study., ASNR 53rd Annual Meeting & The Foundation of the ASNR Symposium, Apr. 2015.
8.	Rie Mukai, Naoko Matsui, N Matsumoto, N.T. Dang, Takeshi Nikawa, Hisao Nemoto and Junji Terao : Anti-Oxidative Flavonoid suppresses disuse muscle atrophy in denervation mice., XXVIIth International Conference on Polyphenols &8th Tannin Conference., 2014.
9.	Naoko Matsui, Izumi Ohigashi, Yousuke Takahama and Ryuji Kaji : Increased Hassalls corpuscles in myasthenia gravis patients carrying thymic hyperplasia, Myasthenia 2013, Paris, Jul. 2013.
10.	Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, Nomura Yoshiko, Yousuke Takahama and Ryuji Kaji : Increased Hassalls Corpuscles In Myasthenia Gravis Patients Carrying Thymic Hyperplasia, 11th International congress of neuroimmunology, Nov. 2012.
11.	Sakai Waka, Naoko Matsui, Yuishin Izumi and Ryuji Kaji : Clinical difference between myasthenia gravis patients with an onset age of 50-64 and over 65, European Federation of Neurological Societies (EFNS) 2012, Stockholm, Sep. 2012.

Proceeding of Domestic Conference:

1.	Naoki Kihara, Hiroki Yamazaki, KURODA Kazutaka, FUKUMOTO Tatsuya, Tomoyasu Matsubara, Shotaro Haji, Ryosuke Miyamoto, Nobuaki Yamamoto, Koji Fujita, Naoko Matsui and Yuishin Izumi : 卵巣奇形腫の診断までに時間を要した抗 NMDA 受容体脳炎の1例, 第15回四国神経懇話会, Feb. 2024.
2.	Naoko Matsui, MOCHIZUKI Ayumu, MUTO Kohei, Yuki Yamamoto and Yuishin Izumi : 当院における難治MG例の検討, 第35回日本神経免疫学会学術集会, Sep. 2023.
3.	Naoko Matsui and Yuishin Izumi : Stiff-person症候群の現状と課題, 第35回日本神経免疫学会学術集会, Sep. 2023.
4.	Naoko Matsui and Yuishin Izumi : スティッフパーソン症候群全国調査最終報告とバイオマーカー探索, 厚生労働省難治性疾患政策研究班(神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証研究班)班会議, Jan. 2023.
5.	YAMAKAMI Kei, HANADA Kenta, Yuki Yamamoto, Hiroki Yamazaki, Yusuke Osaki, Naoko Matsui, Koji Fujita and Yuishin Izumi : 尿閉・便秘を呈したフィッシャー症候群の34歳男性例, 第112回日本神経学会中国・四国地方会, Dec. 2022.
6.	Naoko Matsui, Hiroki Yamazaki, 高松直子, Takeshi Yoshida, Koji Fukushima, 高田忠幸, Yusuke Osaki, 田中惠子, 久保宣明 and Yuishin Izumi : Stiff-person症候群との鑑別に筋超音波検査が有用であった好酸球性筋膜炎の一例,, 日本臨床神経生理学会第52回学術大会, Nov. 2022.
7.	清水文崇, 佐藤亮太, 水上洋一, 渡邊健司, 三澤園子, Naoko Matsui, 竹下幸男, 前田敏彦, Yuishin Izumi, 桑原聡, 神田隆 and 古賀道明 : 末梢慢性炎症性脱髄性多発ニューロパチーと多巣性運動ニューロパチー患者IgGが血液神経関門に及ぼす影響の解析, 第34回日本神経免疫学会学術集会, Oct. 2022.
8.	Naoko Matsui, Hiroki Yamazaki, 高松直子, Takeshi Yoshida, Koji Fukushima, 高田忠幸, Yusuke Osaki, 田中惠子, 久保宣明 and Yuishin Izumi : Stiff-person症候群との鑑別に筋超音波検査が有用であった好酸球性筋膜炎の一例, 第34回日本神経免疫学会学術集会, Oct. 2022.
9.	Yuishin Izumi, Naoko Matsui, Yohhei Yamamoto, 田中惠子, 雑賀玲子, 飯塚高浩, 松井真, Ryuji Kaji and 桑原聡 : 自己免疫疾患 Stiff-person症候群の全国調査, 第34回日本神経免疫学会学術集会, Oct. 2022.
10.	清水文崇, 佐藤亮太, 水上洋一, 渡邊健一, 三澤園子, Naoko Matsui, 竹下幸男, 前田敏彦, Yuishin Izumi, 桑原聡, 神田隆 and 古賀道明 : 慢性炎症性脱髄性多発ニューロパチーと多巣性運動ニューロパチー患者免疫グロブリンGが血液神経関門に及ぼす影響の解析, 第33回日本末梢神経学会学術集会, Sep. 2022.
11.	Yohhei Yamamoto, Naoko Matsui, 田中惠子, 松井真, 桑原聡 and Yuishin Izumi : スティッフパーソン症候群の全国調査, 第63回日本神経学会学術大会, May 2022.
12.	山本遥平, Naoko Matsui, 田中惠子, 松井真, 桑原聡 and Yuishin Izumi : スティッフパーソン症候群の全国調査, 第33回日本神経免疫学会学術集会(口演:ワークショップ8), Oct. 2021.
13.	Yohhei Yamamoto, Naoko Matsui, 織田史子, 小澤由希子, 金井哲也, 鵜沢顕之, Izumi Ohigashi, Kazuya Kondo, 桑原聡, 山村隆 and Yuishin Izumi : 重症筋無力症患者の胸腺ではプラズマブラストが増加している, 第32回日本神経免疫学会学術集会, Oct. 2020.
14.	福本竜也, Ryosuke Miyamoto, Koji Fujita, Naoko Matsui and Yuishin Izumi : 抗AMPA受容体抗体による傍腫瘍性神経症候群の76歳男性例, 第32回日本神経免疫学会学術集会, Oct. 2020.
15.	花田健太, Yusuke Osaki, 福本竜也, Naoko Matsui, Yuishin Izumi and 浦岡秀行 : 初期に頭部画像病変を欠くCISが先行し，10年後に診断された多発性硬化症の一例, 第61回日本神経学会学術大会, Aug. 2020.
16.	Yusuke Osaki, Wataru Sako, Shotaroh Haji, Nagahisa Murakami, Naoko Matsui and Yuishin Izumi : 傍腫瘍性視神経脊髄炎関連疾患(NMOSD)の高齢男性例, 第61回日本神経学会学術大会, Aug. 2020.
17.	Yohhei Yamamoto, Naoko Matsui, Izumi Ohigashi, Kazuya Kondo and Yuishin Izumi : 重症筋無力症患者の胸腺におけるB細胞分画と濾胞性ヘルパーT細胞の解析, 第39回日本胸腺研究会, Feb. 2020.
18.	Naoko Matsui : MG診療の現状と課題-MGの治療選択, 第49回日本臨床神経生理学会学術大会, Nov. 2019.
19.	Yohhei Yamamoto, Naoko Matsui, 織田史子, 小澤由希子, 金井哲也, 鵜沢顕之, Izumi Ohigashi, Hiroyuki Kondo, Kazuya Kondo, Tetsuya Kitagawa, 桑原聡, 山村隆, Yuishin Izumi and Ryuji Kaji : 重症筋無力症患者の胸腺におけるB細胞分画と濾胞性ヘルパーT細胞の解析, 第31回日本神経免疫学会学術集会, Vol.24, No.1, 140, Sep. 2019.
20.	Naoko Matsui : ヒト胸腺上皮細胞解析への試み, 第31回日本神経免疫学会学術集会, Vol.24, No.1, 99, Sep. 2019.
21.	Naoko Matsui, Kazutaka Kuroda, Ryosuke Oki, Nagahisa Murakami, Hiroki Yamazaki, 梶龍兒 and Yuishin Izumi : Heat pack testで症状の改善を認めた全身型重症筋無力症の一例, 第31回日本神経免疫学会学術集会, Sep. 2019.
22.	Yohei Yamamoto, Naoko Matsui, Fumiko Oda, Yukiko Ozawa, Tetsuya Kanai, Akiyuki Uzawa, Izumi Ohigashi, Hiroyuki Kondo, Kazuya Kondo, Tetsuya Kitagawa, Takashi Yamamura, Satoshi Kuwabara, Yuishin Izumi and Ryuji Kaji : B cell subsets and T follicular helper cells in myasthenia gravis thymus, 第60回日本神経学会学術大会, May 2019.
23.	Toru Sawada, Kazuya Kondo, Naoko Matsui, 鈴木恵美, Ryo Yamada, Mika Takashima, Daisuke Matsumoto, Naoya Kawakita, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Hiromitsu Takizawa and Akira Tangoku : 重症筋無力症に対する拡大胸腺摘出術の有効性について, 第36回日本呼吸器外科学会総会, May 2019.
24.	高橋美和, Naoko Matsui, 石田光代, 岡本秀樹, 福田直也, 芝麗, 泉千恵, 河野綾, 桑内敬子, 井口和子, Yuishin Izumi, Ryuji Kaji and Shoji Kagami : 障がい者福祉からみた難病・小児慢性特定疾病支援におけるジレンマ, 第6回日本難病医療ネットワーク学会学術集会, Nov. 2018.
25.	Yamamoto Yohhei, Naoko Matsui, Kazuya Kondo, Izumi Ohigashi, Yousuke Takahama, Nakagawa Hidewaki, Yuishin Izumi and Ryuji Kaji : Analysis of human thymic epithelial cells, 第59回日本神経学会学術大会, May 2018.
26.	Naoko Matsui : 多発性硬化症-最近の治療の話題-, 第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2017.
27.	山上圭, Takahiro Furukawa, Nagahisa Murakami, Naoko Matsui, Yuishin Izumi and Ryuji Kaji : 未治療の全身性サルコイドーシスに合併した進行性多巣性白質脳症, 第22回日本神経感染症学会, Oct. 2017.
28.	Naoko Matsui, Izumi Ohigashi, Myn Muhammad Uddin, Kaito Sasaka, Yohhei Yamamoto, Takahiro Furukawa, Kazuya Kondo, 中川英刀, Ryuji Kaji and Yousuke Takahama : ヒト胸腺を用いた胸腺上皮細胞の解析, 第29回日本神経免疫学会学術集会, Oct. 2017.
29.	Yohhei Yamamoto, Naoko Matsui, 鵜沢顕之, Kaito Sasaka, Takahiro Furukawa, Kazuya Kondo, Tetsuya Kitagawa, 桑原聡, 山村隆 and Ryuji Kaji : MG患者の胸腺と末梢血におけるB細胞の解析, 第29回日本神経免疫学会学術集会, Oct. 2017.
30.	Naoko Matsui : MG診療の実情と胸腺の話題, 第29回日本神経免疫学会学術集会イブニングセミナー3 重症筋無力症の治療目標と最新の話題, Oct. 2017.
31.	高橋美和, Naoko Matsui, 石田光代, 桑内敬子, 鈴木察子, Shoji Kagami, Yuishin Izumi and Ryuji Kaji : 障がい者福祉からみた難病・小児慢性特定疾病の実態調査, 第5回日本難病医療ネットワーク学会学術集会, Sep. 2017.
32.	Naoko Matsui, Izumi Ohigashi, Yamamoto Yohei, Kazuya Kondo, Yousuke Takahama and Ryuji Kaji : Approach for analysis of human thymic epithelial cells, XX World Congress of Neurology, Sep. 2017.
33.	Hanada Kenta, Naoko Matsui, Hiroyuki Nodera, Kuzume Daisuke, Kenta Sato, Iwasa Naoki, Unai Yuki, Saka Waka, Yoshimichi Miyazaki, Yamazaki Hiroki, Yusuke Osaki, Takahiro Furukawa, Yamasaki Masahiro, Yuishin Izumi, Kusunoki Susumu, Kokichi Arisawa and Ryuji Kaji : Guillain-Barre syndrome in a local area in Japan, 2006-2015: An epidemiological and clinical study of 108 patients, XX World Congress of Neurology, Sep. 2017.
34.	Wataru Sako, Takashi Abe, Yuishin Izumi, Naoko Matsui, Masafumi Harada and Ryuji Kaji : The local neuronal activity associated with GABA in amyotrophic lateral sclerosis, 第40回日本神経科学大会, Jul. 2017.
35.	Ryuji Kaji, Hiroyuki Nodera, 十川和樹, 高松直子 and Naoko Matsui : テクスチャ解析による筋エコーでのIBM類似疾患との鑑別, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(平成28年度), Feb. 2017.
36.	Naoko Matsui, Takahiro Furukawa, 田中惠子 and Ryuji Kaji : スティッフパーソン症候群の診断および重症度分類のための調査, 厚生労働省難治性疾患(神経免疫疾患)政策および実用化研究班平成28年度合同班会議, 31-32, Jan. 2017.
37.	鶴尾美穂, Akio Kuroda, Tomoyuki Yuasa, Takeshi Kondo, Mizuho Kinouchi, Naoko Matsui, 細井恵美子, Masahiro Abe, Toshio Matsumoto, Munehide Matsuhisa and 寺澤敏秀 : γグロブリン療養後に一過性のGAD抗体価上昇がみられた糖尿病の一例, 日本糖尿病学会中国四国地方会第54回総会, Nov. 2016.
38.	石田光代, Naoko Matsui, 高橋美和, 杉原治美, Yuishin Izumi, 西田喜彦 and Ryuji Kaji : 就労可能な難病患者における共通特性の検討, 第4回日本難病医療ネットワーク学会学術集会, 113, Nov. 2016.
39.	Naoko Matsui, Hiroki Yamazaki, Shingen Nakamura, Yuishin Izumi, 中道一生, 西條政幸 and Ryuji Kaji : 非HIV関連進行性多巣性白質脳症の3例, 第21回日本神経感染症学会, 228, Oct. 2016.
40.	Naoko Matsui : 胸腺免疫からみた重症筋無力症, 第11回小児重症筋無力症研究会, Sep. 2016.
41.	武藤浩平, Naoko Matsui, 垂髪祐樹, Waka Sakai, Takahiro Furukawa and Ryuji Kaji : 難治性の抗アセチルコリン受容体抗体陽性重症筋無力症に対するrituximabの使用経験, 第28回日本神経免疫学会学術集会, 116, Sep. 2016.
42.	Masaki Kamada, Shunya Nakane, Naoko Matsui, 樋口理, Waka Sakai, Koji Fujita, Yuishin Izumi, 松尾秀徳 and Ryuji Kaji : 抗MuSK抗体陽性の眼筋型重症筋無力症, 第28回日本神経免疫学会学術集会, 172, Sep. 2016.
43.	Naoko Matsui, 岩佐直毅, Yoshimichi Miyazaki, Waka Sakai, Takahiro Furukawa, 垂髪祐樹, Hiroki Yamazaki, Yusuke Ohsaki, Hiroyuki Nodera, 葛目大輔, 山崎正博, 楠進 and Ryuji Kaji : 軸索型のギラン・バレー症候群とフィッシャー症候群は春から夏にかけて発症しやすい, 第28回日本神経免疫学会学術集会, 160, Sep. 2016.
44.	高橋拓, 垂髪祐樹, Hiroki Yamazaki, Takahiro Furukawa, Nobuaki Yamamoto, Naoko Matsui, Yuishin Izumi and Ryuji Kaji : 発作性心房細動，心筋症を合併した抗ミトコンドリア抗体陽性筋炎の一例, 第100回日本神経学会中国四国地方会, 73, Jun. 2016.
45.	山本雄貴, Naoko Matsui, 平松有, 垂髪祐樹, 大崎裕亮, Yoshimichi Miyazaki, Hiroyuki Nodera, 西野一三, Yuishin Izumi, 高嶋博 and Ryuji Kaji : 末梢神経障害が目立ち，診断に苦慮した遅発型三頭酵素欠損症の60歳男性例, 第100回日本神経学会中国四国地方会, 47, Jun. 2016.
46.	Naoko Matsui : よりよい専門医療をめざして~大学病院の立場から, 日本神経学会市民公開講座とくしま難病フォーラム, May 2016.
47.	武藤浩平, Naoko Matsui, 垂髪祐樹, 酒井和香, 古川貴大 and Ryuji Kaji : 難治性の抗アセチルコリン受容体抗体陽性重症筋無力症に対するrituximabの使用経験, 第57日本神経学会学術大会, 363, May 2016.
48.	金喜栄, Naoko Matsui, Izumi Ohigashi, 古川貴大, Yousuke Takahama and Ryuji Kaji : ヒト胸腺を用いた胸腺上皮細胞解析への試み, 第57日本神経学会学術大会, 367, May 2016.
49.	杉原治美, Naoko Matsui, 岡本秀樹, 井口和子, 鈴木察子, Yuishin Izumi and Ryuji Kaji : 神経難病における支援ネットワークつくりー大学病院の立場から, 第57回日本神経学会学術大会, 395, May 2016.
50.	Naoko Matsui, Hiroyuki Nodera, 高松直子, Yuka Terasawa, 森敦子, Yoshimitsu Shimatani, 大崎裕亮, 丸山サラデイーニ恵子, Yuishin Izumi and Ryuji Kaji : 下腿三頭筋におけるエコー輝度の解離は封入体筋炎に特徴的である, 第57日本神経学会学術大会, 657, May 2016.
51.	石田光代, Naoko Matsui, 橋口修二, Yuishin Izumi, 西田喜彦 and Ryuji Kaji : 徳島難病患者における就労状況の現状と課題, 第57日本神経学会学術大会, 675, May 2016.
52.	古川貴大, Naoko Matsui, Ryosuke Miyamoto, Wataru Sako, Nobuaki Yamamoto, Yuishin Izumi, 高橋幸利 and Ryuji Kaji : 成人発症の片側大脳萎縮症の臨床像の検討, 第57日本神経学会学術大会, 639, May 2016.
53.	Yoshimichi Miyazaki, Naoko Matsui and Ryuji Kaji : 免疫性ニューロパチーにおけるIVIg前後の血清IgG値の変動, 第57回日本神経学会学術大会, 592, May 2016.
54.	Naoko Matsui : Approach from T cell development in MG thymus, 第57回日本神経学会学術大会, 183, May 2016.
55.	Naoko Matsui, Izumi Ohigashi, Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama : ヒト胸腺を用いた胸腺上皮細胞の解析, 第35回日本胸腺研究会, Feb. 2016.
56.	沖良祐, Toshitaka Kawarai, Ryosuke Miyamoto, 森敦子, 塚本愛, Naoko Matsui, Yoshimichi Miyazaki, Yuishin Izumi, 西田善彦 and Ryuji Kaji : 30歳を過ぎて痙性対麻痺および痙性構音障害が顕在化した新規SPG11変異を持つ同胞例, 第99回日本神経学会中国・四国地方会, Dec. 2015.
57.	中山知彦, Takeo Tominaga, 山崎博輝, Naoko Matsui and Tetsuro Ohmori : ミルタザピン投与後に改善が得られた進行性多巣性白質脳症の一例, 第56回中国・四国精神神経学会, Nov. 2015.
58.	Naoko Matsui, 酒井和香, 古川貴大, Yuishin Izumi and Ryuji Kaji : 後期発症MGの臨床像, 神経免疫学, Vol.20, No.1, 140, Sep. 2015.
59.	古川貴大, Naoko Matsui, 高橋利幸, Naozumi Ishimaru and Ryuji Kaji : 耳下腺炎後に視神経や脊髄以外に広範な白質病変を来し，抗AQP4抗体が陽性であったシェーグレン症候群の1例, 神経免疫学, Vol.20, No.1, 114, Sep. 2015.
60.	Naoko Matsui, Yoshimichi Miyazaki, 大崎裕亮, Ai Miyashiro, 森敦子, 丸山恵子, Yoshimitsu Shimatani, Koji Fujita, Hiroyuki Nodera and Ryuji Kaji : ギラン・バレー症候群に対するIVIg前後の血清IgG値の変動と治療効果, 第26回日本神経免疫学会学術集会, Sep. 2015.
61.	野田和克, 山崎博輝, Naoko Matsui, 塚本愛, 中道一生, Yuishin Izumi and Ryuji Kaji : 治療が奏功した非HIV関連進行性多巣性白質脳症の2例, 第98回日本神経学会中国・四国地方会, Jun. 2015.
62.	山下雄也, 山崎博輝, Yoshimichi Miyazaki, 塚本愛, Naoko Matsui, Yuishin Izumi, Ryuji Kaji, 西田善彦 and 鈴木重明 : 免疫治療が著効した抗SRP抗体陽性ミオパチーの1例, 第112回日本内科学会四国地方会, Jun. 2015.
63.	古川貴大, Naoko Matsui, Ai Miyashiro, Hiroyuki Nodera, Koji Fujita, 清水文祟, 宮本勝一, 高橋幸利, 神田隆, 楠進 and Ryuji Kaji : MMNのサイトカイン・ケモカインプロファイル, 第56日本神経学会学術大会, May 2015.
64.	Naoko Matsui, Waka Sakai, Takahiro Furukawa, Takako Matsuoka, Masakazu Nakamura, Toshimasa Aranami, Kazuya Kondo, Tetsuya Kitagawa, Yousuke Takahama, Takashi Yamamura and Ryuji Kaji : B cell analysis in human thymus, 第56日本神経学会学術大会, May 2015.
65.	武藤浩平, 酒井和香, Naoko Matsui, 沖良祐, 梶誠兒, 武内俊明, 丸山恵子, 大崎裕亮, Nobuaki Yamamoto, Ai Miyashiro, Hiroyuki Nodera, 樋口理, Yuishin Izumi and Ryuji Kaji : 当初ALSを疑われた高齢発症抗MuSK抗体陽性MGの一例, 第97回日本神経学会中国・四国地方会, Dec. 2014.
66.	竹内俊明, 宮本亮介, 大崎裕亮, Nobuaki Yamamoto, Koji Fujita, Naoko Matsui, Yuishin Izumi and Ryuji Kaji : 弛緩性麻痺と不随意運動を呈した日本脳炎の一例, 第111回日本内科学会四国地方会, Nov. 2014.
67.	沖良祐, Koji Fujita, Naoko Matsui, 村上永尚, 宮本亮介, Yoshimichi Miyazaki, Yuishin Izumi and Ryuji Kaji : 高齢発症破傷風例の治療経験を通じた本邦破傷風診療に関する提言, 第19回日本神経感染症学会総会, Sep. 2014.
68.	大崎裕亮, Naoko Matsui, 葛目大輔, Koji Fujita, Hiroyuki Nodera, 尾本雅俊, 海田賢一, Yuishin Izumi, 神田隆 and Ryuji Kaji : 抗Neurofascin抗体陽性Lewis-Sumner症候群の1例, 第96回日本神経学会中国・四国地方会, Jun. 2014.
69.	Naoko Matsui, 古川貴大 and Ryuji Kaji : 重症筋無力症患者の過形成胸腺ではハッサル小体が増加している, 第55回日本神経学会学術大会, May 2014.
70.	Naoko Matsui, 酒井和香, Yuishin Izumi, 西田善彦 and Ryuji Kaji : 老年発症重症筋無力症の治療戦略, 第25回日本老年医学会四国地方会, Feb. 2014.
71.	Yoshimichi Miyazaki, Naoko Matsui, Koji Fujita, 大崎裕亮, 森敦子, 丸山恵子, Yoshimitsu Shimatani, Hiroyuki Nodera and Ryuji Kaji : ギラン・バレー症候群に対するIVIg前後の血清IgG値の変動と治療効果, Clinical Neurology, Vol.54, No.Suppl., S107, 2014.
72.	Yoshimichi Miyazaki, Masaki Kamada, Koji Fujita, Naoko Matsui, Yuishin Izumi, 村山繁雄 and Ryuji Kaji : 急激な経過をたどったLymphomatosis cerebriの1例, 第109回日本内科学会四国地方会, Dec. 2013.
73.	Koji Fujita, 湯浅龍彦, 高橋幸利, 田中恵子, 岩崎靖, Naoko Matsui, Yuishin Izumi and Ryuji Kaji : 抗NMDA受容体抗体陽性のCreutzfeldt-Jakob病と免疫関連脳炎の鑑別, 第25回日本神経免疫学会学術集会, Nov. 2013.
74.	Naoko Matsui, 古川貴大, Koji Fujita, Yoshimichi Miyazaki, Kenta Sato, Yuishin Izumi, 西田善彦 and Ryuji Kaji : Fingolimodはrecent thymic emigrantへの影響, 第25回日本神経免疫学会学術集会, Nov. 2013.
75.	Naoko Matsui : stiff-person, Isaacs症候群のアフェレシス(シンポジウム:難治性神経筋疾患におけるアフェレシス療法), 第34回日本アフェレシス学会学術大会, Nov. 2013.
76.	Naoko Matsui, 古川貴大, Yoshimichi Miyazaki, Yuka Terasawa, Yuishin Izumi, 西田善彦 and Ryuji Kaji : Fingolimodは重症筋無力症の治療となりうるか?, 第54回日本神経学会学術大会, May 2013.
77.	Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, Yousuke Takahama and Ryuji Kaji : 重症筋無力症の過形成胸腺ではハッサル小体が増加している, 第32回日本胸腺研究会, Feb. 2013.
78.	Naoko Matsui, Izumi Ohigashi and Yousuke Takahama : Increased Hassalls corpuscles in myasthenia gravis patients carrying thymic hyperplasia, 41st Annual Meeting of The Japanese Society for Immunology, Dec. 2012.
79.	Naoko Matsui, Izumi Ohigashi and Yousuke Takahama : Increased Hassalls Corpuscles In Myasthenia Gravis Patients Carrying Thymic Hyperplasia, 第41回日本免疫学会学術集会, Dec. 2012.
80.	Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, 野村芳子, Yousuke Takahama and Ryuji Kaji : 重症筋無力症の過形成胸腺ではハッサル小体が増加している, 第24回日本神経免疫学会学術集会, Sep. 2012.
81.	Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, 野村芳子, Yousuke Takahama and Ryuji Kaji : 重症筋無力症の過形成胸腺ではハッサル小体が増加している, 第24回日本神経免疫学会, Sep. 2012.
82.	清水文祟, 佐野泰照, 斉藤和幸, 安部真彰, 前田敏彦, 春木明代, Naoko Matsui, Ai Miyashiro, Ryuji Kaji and 神田隆 : 多巣性運動ニューロパチー血清は血液神経関門を破綻させる, 第53回日本神経学会学術大会, May 2012.
83.	酒井和香, Naoko Matsui, Yuka Terasawa, Koji Fujita, Kenta Sato, Masaki Kamada, Yuishin Izumi and Ryuji Kaji : 50歳以上発症重症筋無力症における臨床像 64歳迄vs65歳以上, 第53回日本神経学会学術大会, May 2012.
84.	Naoko Matsui : 多巣性運動ニューロパチー:疫学と治療の実態, 第53回日本神経学会学術大会, May 2012.
85.	Naoko Matsui, Izumi Ohigashi, 野村芳子, Yousuke Takahama and Ryuji Kaji : 重症筋無力症患者胸腺における制御性T細胞ならびにハッサル小体の役割, Clinical Neurology, Vol.51, No.12, 1300, Dec. 2011.
86.	山本伸昭, 酒井和香, 宮本亮介, 宮城愛, Kenta Sato, Yuka Terasawa, Naoko Matsui, Koutaro Asanuma, Yuishin Izumi and Ryuji Kaji : 高齢発症のNeuromyelitis optica(NMO)についての検討, Clinical Neurology, Vol.51, No.2, 154, Feb. 2011. (Keyword) *視神経脊髄炎 / Homo sapiens
87.	宮本亮介, 山本伸昭, 宮城愛, Yuka Terasawa, Kenta Sato, Naoko Matsui, Koutaro Asanuma, Yuishin Izumi and Ryuji Kaji : 遷延する膀胱直腸障害を主徴としたataxic sensory-autonomic neuropathyの一例, Clinical Neurology, Vol.51, No.2, 157, Feb. 2011. (Keyword) IgG(治療的利用); 運動失調症(診断,合併症,薬物療法); 神経系疾患(診断,合併症,薬物療法); 直腸疾患(病因); 膀胱疾患(病因); 静脈内注入 / 神経伝導速度 / ヒト; 成人(19∼44); 女
88.	Yoshimichi Miyazaki, Ai Miyashiro, Nobuaki Yamamoto, Kenta Sato, Yuka Terasawa, Naoko Matsui, Koutaro Asanuma, Yuishin Izumi and Ryuji Kaji : t-PA治療が奏功した超高齢発症脳梗塞の2例, Japanese Journal of Geriatrics, Vol.48, No.4, 418, 2011. (Keyword) 脳梗塞(薬物療法) Tissue Plasminogen Activator(治療的利用) ヒト高齢者(80~) 女
89.	宇高憲吾, Naoko Matsui, 宮本亮介, Yuka Terasawa, Kenta Sato, Koutaro Asanuma, Yuishin Izumi, Ryuji Kaji, Shiroh Fujii, Kyoko Takeuchi, Masahiro Abe and Masafumi Harada : 多発性骨髄腫の経過中に進行性多巣性白質脳症をきたした一例, Shikoku Acta Medica, Vol.66, No.5-6, 198, Dec. 2010. (Keyword) Cytarabine(治療的利用); Prednisolone(治療的利用); 自家移植; 骨髄腫-多発性(合併症,治療); 白質脳症-進行性多巣性(合併症,画像診断,薬物療法); Mirtazapine(治療的利用); FLAIR法; 末梢血幹細胞移植 / ヒト; 中年(45∼64); 男
90.	宮城愛, Yuka Terasawa, Naoko Matsui, 山本伸昭, Kenta Sato, Koutaro Asanuma, Yuishin Izumi and Ryuji Kaji : ステロイド投与が奏功した卵巣奇形腫を伴う抗グルタミン酸受容体抗体陽性脳炎の1例, Clinical Neurology, Vol.50, No.7, 517, Oct. 2010. (Keyword) Methylprednisolone(治療的利用); 奇形腫(診断); 抗体(血液); 卵巣腫瘍(診断); Glutamate Receptors; 脳炎-辺縁系(診断,免疫学,薬物療法); パルス療法(薬物療法) / ヒト; 成人(19∼44); 女
91.	島谷佳光, Naoko Matsui, 宮城愛, Koutaro Asanuma, Koji Fujita, Yuka Terasawa, Kenta Sato, Yuishin Izumi and Ryuji Kaji : Neuromyelitis opticaにおけるVEPの検討, Japanese Journal of Clinical Neurophysiology, Vol.38, No.5, 330, Oct. 2010. (Keyword) 視神経脊髄炎; 視覚誘発電位 / Homo sapiens
92.	高松直子, Yuka Terasawa, 山本伸昭, Kenta Sato, 宮本亮介, 宮城愛, 島谷佳光, Naoko Matsui, Koutaro Asanuma, Yuishin Izumi and Ryuji Kaji : 超音波所見が診断に有用であった筋サルコイドーシスの1例, Japanese Journal of Clinical Neurophysiology, Vol.38, No.5, 333, Oct. 2010. (Keyword) 眼筋; 眼瞼下垂(病因); 超音波診断; サルコイドーシス(合併症); *筋力低下(病因) / ヒト; 中年(45∼64); 女

Et cetera, Workshop:

1.	Naoko Matsui, Kazuya Kondo, Yuishin Izumi and Izumi Ohigashi : 正常ヒト胸腺を用いた胸腺上皮細胞のRNA シークエンス解析, 第43回日本胸腺研究会, Feb. 2024.
2.	Naoko Matsui, Hiroki Yamazaki, 高松直子, Ryosuke Miyamoto, Hiroyuki Morino, 西野一三, Ryuji Kaji and Yuishin Izumi : 当院で経験したIBM兄弟例, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(令和5年度), Feb. 2024.
3.	Naoko Matsui, 田中恵子, 桑原聡 and Yuishin Izumi : スティッフパーソン症候群-診断基準の検証とバイオマーカー探索, 神経免疫疾患領域における難病の医療水準と患者のQOL向上に資する研究(神経免疫班)令和5年度合同班会議, Jan. 2024.
4.	Yuishin Izumi, Naoko Matsui, 田中恵子, 佐藤泰憲 and 桑原聡 : アイザックス症候群の全国調査, 神経免疫疾患領域における難病の医療水準と患者のQOL向上に資する研究(神経免疫班) 令和5年度合同班会議, Jan. 2024.
5.	Riho Tada, MUTO Kohei, Naoko Matsui, Koji Fujita and Yuishin Izumi : 散在性の脳実質病変を認め自己免疫性脳炎を疑った一例, 第114回日本神経学会中国・四国地方会, Dec. 2023.
6.	Ryuji Kaji, Naoko Matsui, Hiroki Yamazaki, 高松直子, 山下賢, 西野一三 and Yuishin Izumi : 当院におけるIBM患者のまとめ, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(令和4年度), Feb. 2023.
7.	Yuishin Izumi, Naoko Matsui, 田中惠子, 佐藤泰憲 and 桑原聡 : アイザックス症候群の全国調査, 神経免疫疾患のエビデンスによる診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証研究班(神経免疫疾患)政策および実用化研究班令和4年度合同班会議, Jan. 2023.
8.	Ryuji Kaji, Hiroki Yamazaki, Koji Fukushima, Naoko Matsui, 高松直子, 西野一三 and Yuishin Izumi : 当院で診断したIBM患者における筋超音波所見の長期的追跡, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(令和3年度), Feb. 2022.
9.	Yohhei Yamamoto, Naoko Matsui, 鵜沢顕之, 桑原聡, 山村隆 and Yuishin Izumi : 疾患活動性の高い重症筋無力症患者の胸腺ではプラズマブラストが増加している, 神経免疫疾患のエビデンスによる診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証研究班(神経免疫疾患)政策および実用化研究班令和3年度合同班会議, Jan. 2022.
10.	Yuishin Izumi, Naoko Matsui, Yohhei Yamamoto, 中村幸志, 栗山長門, 中村好一, 田中恵子, 松井真 and 桑原聡 : アイザックス症候群・スティッフパーソン症候群疫学調査, 神経免疫疾患のエビデンスによる診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証研究班(神経免疫疾患)政策および実用化研究班令和3年度合同班会議, Jan. 2022.
11.	Naoko Matsui, 山本遥平, Izumi Ohigashi, Kazuya Kondo and Yuishin Izumi : 重症筋無力症患者の胸腺ではプラズマブラストが増加している, 第40回日本胸腺研究会, Feb. 2021.
12.	Naoko Matsui, Mika Takahara, 西野一三, Ryuji Kaji and Yuishin Izumi : 顕著な嚥下障害をきたした抗NT5C1A抗体陽性高齢女性例, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(令和2年度), Feb. 2021.
13.	Naoko Matsui, Yohhei Yamamoto, 田中恵子, Ryuji Kaji and Yuishin Izumi : スティッフパーソン症候群全国調査第三報, 神経免疫疾患のエビデンスによる診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証研究班(神経免疫疾患)政策および実用化研究班令和2年度合同班会議, Jan. 2021.
14.	Naoko Matsui and Yuishin Izumi : アイザックス症候群とスティッフパーソン症候群の診断基準と重症度分類, 神経免疫疾患のエビデンスによる診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証研究班(神経免疫疾患)政策および実用化研究班令和2年度合同班会議, Jan. 2021.
15.	Naoko Matsui, Yusuke Osaki, 西野一三, 山下賢 and Yuishin Izumi : 封入体筋炎における抗NT5C1A抗体と臨床像:当院症例について, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(令和元年度) 東北大学医学部星陵会館大会議室, Jan. 2020.
16.	Naoko Matsui, Yohhei Yamamoto, Yuishin Izumi, 田中惠子 and Ryuji Kaji : スティッフパーソン症候群全国調査第二報, 神経免疫疾患のエビデンスによる診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証研究班(神経免疫疾患)政策および実用化研究班令和元年度合同班会議, Jan. 2020.
17.	Naoko Matsui : 重症筋無力症-胸腺の研究から実臨床への応用-, 第7回姫路免疫性神経疾患研究会, Jul. 2019.
18.	Toru Sawada, Kazuya Kondo, Naoko Matsui, 鈴木恵美, 山田亮, Mika Takashima, Daisuke Matsumoto, Naoya Kawakita, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Hiromitsu Takizawa and Akira Tangoku : 当院におけるMGに対する拡大胸腺摘出術後の予後成績, 第38回日本胸腺研究会, Feb. 2019.
19.	Hiroyuki Nodera, Naoko Matsui, 高松直子, Yuishin Izumi and Ryuji Kaji : デープラーニングによるIBMおよび類縁疾患の筋エコー画像判別, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(平成30年度), Feb. 2019.
20.	Yohhei Yamamoto, Naoko Matsui, Yuishin Izumi, 田中惠子 and Ryuji Kaji : スティッフパーソン症候群全国調査, 神経免疫疾患のエビデンスによる診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証研究班(神経免疫疾患)政策および実用化研究班平成30年度合同班会議, Jan. 2019.
21.	Naoko Matsui, Izumi Ohigashi, 山本遥平, 中川英刀, Kazuya Kondo and Yousuke Takahama : ヒト胸腺を用いた胸腺上皮細胞の解析, 第37回日本胸腺研究会, Feb. 2018.
22.	Naoko Matsui, Hiroyuki Nodera, 高松直子, Yuishin Izumi and Ryuji Kaji : 当施設における封入体筋炎のアップデート, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(平成29年度), Feb. 2018.
23.	Naoko Matsui, Yohhei Yamamoto, Takahiro Furukawa, 田中惠子 and Ryuji Kaji : スティッフパーソン症候群全国一次調査, 神経免疫疾患のエビデンスによる診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証研究班(神経免疫疾患)政策および実用化研究班平成29年度合同班会議, Jan. 2018.
24.	Naoko Matsui : 診断・診療上の注意点について, 平成29年度徳島県難病・小児慢性指定医及び協力難病指定医研修会プログラム, Dec. 2017.
25.	Naoko Matsui : 多発性硬化症の治療について, 第3回難病医療講演・医療相談会, Nov. 2017.
26.	Naoko Matsui : 難病患者の日常生活と就労に関する調査, 第15回徳島神経難病セミナー, Jul. 2017.
27.	Naoko Matsui : パーキンソン病の診断と治療, 第24回パーキンソン仲間の会オリーブ医療講演会, Jul. 2017.
28.	Naoko Matsui : 多発性硬化症治療の現状~私の処方意図~, 医薬連携講演会 ~Meet The Expert~, Apr. 2017.
29.	Naoko Matsui, Izumi Ohigashi, 中川英刀, Kazuya Kondo and Yousuke Takahama : ヒト胸腺を用いた胸腺上皮細胞の解析, 第36回日本胸腺研究会, Feb. 2017.
30.	Yohhei Yamamoto, Shotaroh Haji, Ryosuke Miyamoto, Takahiro Furukawa, Naoko Matsui, Yuishin Izumi and Ryuji Kaji : たこつぼ型心筋症を合併したMGクリーゼの一例, 第5回東四国神経免疫研究会, Jan. 2017.
31.	Naoko Matsui : 多発性硬化症の診断と治療, 阿波吉野川支部・名西支部薬剤師会合同研修会, Jan. 2017.
32.	Naoko Matsui : 特定疾病医療に係る診療・診断書作成上の留意点, 平成28年度徳島県難病指定医・小児慢性特定疾患指定医及び協力難病指定医研修会プログラム, Dec. 2016.
33.	Naoko Matsui : DMD治療をどのように開始すべきか?, 中国四国MS Expert Summit, Dec. 2016.
34.	Toshiaki Takeuchi, Naoko Matsui, Yuki Yamamoto, Waka Sakai, 西田善彦, 南里和紀, Yuishin Izumi and Ryuji Kaji : 抗グリアジン抗体+抗GAD抗体陽性の自己免疫性小脳失調症の一例, 第52回亀山正邦記念神経懇話会, Nov. 2016.
35.	Naoko Matsui : 重症筋無力症の治療について, 難病医療講演・医療相談会, Nov. 2016.
36.	Naoko Matsui : 特定疾病医療に係る診療・診断書作成上の留意点, Jul. 2016.
37.	Naoko Matsui : 特定疾病医療に係る診療・診断書作成上の留意点, 平成27年度徳島県協力難病指定医研修会プログラム, Jun. 2016.
38.	Naoko Matsui : 特定疾病医療に係る診療・診断書作成上の留意点, 平成27年度徳島県難病・小児慢性特定疾病指定医及び協力難病指定医研修会プログラム, Feb. 2016.
39.	Naoko Matsui, Izumi Ohigashi, Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama : ヒト胸腺を用いた胸腺上皮細胞の解析, 第35回日本胸腺研究会, 39, Feb. 2016.
40.	酒井和香, Naoko Matsui and Kazuya Kondo : 高齢発症MGの臨床像, 第35回日本胸腺研究会, 51, Feb. 2016.
41.	Ryuji Kaji, Hiroyuki Nodera, 高松直子, Naoko Matsui, 森敦子, Yuka Terasawa, Yoshimitsu Shimatani, 大崎裕亮, 丸山恵子 and Yuishin Izumi : 下腿三頭筋エコー輝度の解離により孤発性封入体筋炎と炎症性筋炎とを鑑別できる, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(平成27年度), 49-50, Feb. 2016.
42.	Ryuji Kaji, Yoshimichi Miyazaki and Naoko Matsui : 免疫性ニューロパチーにおけるIVIg前後の血清IgG値の変動, 厚生労働省難治性疾患(神経免疫疾患)政策及び実用化研究班(平成27年度), Jan. 2016.
43.	Ryuji Kaji, Naoko Matsui and Hiroyuki Nodera : 封入体筋炎における筋エコーの有用性, 厚生労働省難治性疾患(神経免疫疾患)政策および実用化研究班(平成27年度), 70-71, Jan. 2016.
44.	Ryuji Kaji, Naoko Matsui and 古川貴大 : スティッフパーソン症候群の現状と今後の課題, 厚生労働省難治性疾患(神経免疫疾患)政策および実用化研究班(平成27年度), 55-56, Jan. 2016.
45.	Naoko Matsui : 神経内科のみる免疫疾患, 高知医療再生機構平成27年度専門医等不足分野支援事業, Oct. 2015.
46.	Naoko Matsui : 県内におけるこれまでの取り組み・これから, とくしま難病市民公開講座, Sep. 2015.
47.	Naoko Matsui, Yuishin Izumi, Masaki Kamada, 川上秀史 and Ryuji Kaji : 骨Paget病と痙性対麻痺を併発したVCP遺伝子変異によるミオパチーの一例, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(平成26年度), Feb. 2015.
48.	Naoko Matsui, Izumi Ohigashi, Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama : ヒト胸腺を用いた単一細胞解析への試み, 第34回日本胸腺研究会, Feb. 2015.
49.	Naoko Matsui : 胸腺免疫からみた重症筋無力症, 第4回 MG Forum in Chiba, Mar. 2014.
50.	Naoko Matsui, Yasushi Nakagawa, Kazuya Kondo, Ryuji Kaji and Yousuke Takahama : 重症筋無力症の過形成胸腺ではハッサル小体が増加している, 第33回日本胸腺研究会, Feb. 2014.
51.	森下敦司, Kazuya Kondo, Naoko Matsui, Yoshimi Bando, Koichiro Kajiura, Hiromitsu Takizawa, Yasushi Nakagawa, Mitsuteru Yoshida, Yukikiyo Kawakami, Shoji Sakiyama and Akira Tangoku : 重症筋無力症を伴った胸腺のmultiple microcystsの一例, 第33回日本胸腺研究会, Feb. 2014.
52.	Ryuji Kaji, Naoko Matsui, Yoshimitsu Shimatani, Hiroyuki Nodera and Yuishin Izumi : IBMの診断における補助検査の有用性, 稀少難治性筋疾患に関する調査研究班(平成25年度), Jan. 2014.
53.	Ryuji Kaji, Yoshimichi Miyazaki, Naoko Matsui, Koji Fujita, 大崎裕亮, 森敦子, 丸山恵子, Yoshimitsu Shimatani and Hiroyuki Nodera : ギラン・バレー症候群に対するIVIg前後の血清IgG値の変動と治療効果, 免疫性神経疾患に関する調査研究班(平成25年度), Jan. 2014.
54.	Ryuji Kaji, Naoko Matsui, 古川貴大, Kazuya Kondo, Yousuke Takahama and 野村芳子 : 重症筋無力症の発症機序:過形成胸腺ではハッサル小体が増加している, 免疫性神経疾患に関する調査研究班(平成25年度), Jan. 2014.
55.	Ryuji Kaji, 古川貴大, Naoko Matsui, 清水文祟, 神田隆, 宮本勝一, 楠進 and 高橋幸利 : MMNとALSにおけるサイトカイン・プロファイル ∼第2報∼, 免疫性神経疾患に関する調査研究班(平成24年度), Jan. 2013.
56.	Ryuji Kaji, Naoko Matsui, 古川貴大, Yoshimichi Miyazaki and Yuka Terasawa : Fingolimodは重症筋無力症の治療となりうるか?, 免疫性神経疾患に関する調査研究班(平成24年度), Jan. 2013.
57.	Sakai Waka, Naoko Matsui, Koji Fujita and Ryuji Kaji : A case of NMO spectrum disorder associated with SIADH, Sendai Conference 2012, Jul. 2012.

Report:

1.	Ryuji Kaji, Yoshimichi Miyazaki, Naoko Matsui, Koji Fujita, 大崎裕亮, 森敦子, 丸山恵子, Yoshimitsu Shimatani and Hiroyuki Nodera : ギラン・バレー症候群に対するIVIg前後の血清IgG値の変動と治療効果, 免疫性神経疾患に関する調査研究班(平成25年度), 154-155, Tokyo, 2014.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

重症筋無力症の治療方向性を規定する因子の探索 (Project/Area Number: 20K07784 )
Elucidation of myasthenia gravis thymus pathology and development of new treatment (Project/Area Number: 19K23946 )
Elucidating the mechanism of myasthenia gravis in B type thymoma with myasthenia gravis (Project/Area Number: 16K10684 )
Can fingolimod be treatment strategy for myasthenia gravis ? (Project/Area Number: 25870477 )
Regulatory T cells and Hassall's corpuscles in myasthenia gravis patients thymus (Project/Area Number: 23790995 )
Search by Researcher Number (10547954)

Associate Professor : Matsui, Naoko

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)