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Tokushima University > Graduate School of Technology, Industrial and Social Sciences > Division of Science and Technology > Natural Science > Chemistry >
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Tokushima University > Research Clusters > Research Clusters (Registered) > 1704092 機能性物質の開発およびその応用 >
Tokushima University > Research Clusters > Research Clusters (Registered) > 1804030 研究創発を活性化する有機化合物ライブラリーの構築 >
Tokushima University > Research Clusters > Research Clusters (Registered) > 1704080 湿性沈着中の不溶性成分に含まれる越境大気汚染の新規トレーサーの開発 >
Tokushima University > Research Clusters > Research Clusters (Registered) > 1704058 創薬及び機能性分子合成を目指す連続フロー型多成分ワンポット・カップリング反応の開発 >
Tokushima University > Research Clusters > Research Clusters (Registered) > 1704072 不可能を可能とする有機分子合成工場「合成困難な機能性分子の合成」 >
Tokushima University > Faculty of Integrated Arts and Sciences > Department of Mathematical and Material Sciences > Integrated Material Science Studies >
Tokushima University > Research Clusters > Research Clusters (Registered) > 1704084 分子自身により誘起される高次構造形成に基づく機能性表面加工手法の開発 >
Tokushima University > Research Clusters > Research Clusters (Registered) > 1704060 ラボ装置による貴金属ナノ粒子生成挙動のその場観察およびその機能 >
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Research Activity

Field of Study

Chemistry

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.So Masaki, Isao Kii, Yuto Sumida, Tomoe Kato-Sumida, Yasushi Ogawa, Nobutoshi Ito, Mitsuhiro Nakamura, Rie Sonamoto, Naoyuki Kataoka, Takamitsu Hosoya and Masatoshi Hagiwara :
Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis.,
Bioorganic & Medicinal Chemistry, Vol.23, No.15, 4434-4441, 2015.
(DOI: 10.1016/j.bmc.2015.06.018,   PubMed: 26145823,   Elsevier: Scopus)
2.Mitsuhiro Nakamura, Tomoko Suzuki, Norihiro Ishizaka, Jun-ichi Sato and Satoshi Inouye :
Identification of 3-enol sulfate of Cypridina luciferin, Cypridina luciferyl sulfate, in the sea-firefly Cypridina (Vargula) hilgendorfii,
Tetrahedron, Vol.70, No.12, 2161-2168, 2014.
(DOI: 10.1016/j.tet.2014.01.075,   Elsevier: Scopus)
3.Iwano Satoshi, Obata Rika, Miura Chihiro, Kiyama Masahiro, Hama Kazutoshi, Mitsuhiro Nakamura, Amano Yoshiharu, Kojima Satoshi, Hirano Takashi, Maki Shojiro and Niwa Haruki :
Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light,
Tetrahedron, Vol.69, No.19, 3847-3856, 2013.
(DOI: 10.1016/j.tet.2013.03.050,   Elsevier: Scopus)
4.Toshiya Masuda, Inouchi Tomoko, Aya Fujimoto, Shingai Yoshimi, Inai Miyuki, Mitsuhiro Nakamura and Shoji Imai :
Radical Scavenging Activity of Spring Mountain Herbs in the Shikoku Mountain Area and Identification of Antiradical Constituents by Simple HPLC Detection and LC-MS Methods,
Bioscience, Biotechnology, and Biochemistry, Vol.76, No.4, 705-711, 2012.
(DOI: 10.1271/bbb.110837,   PubMed: 22484936)
5.Yoshiyasu Ichikawa, Ken Okumura, Yasunori Matsuda, Tomoyuki Hasegawa, Mitsuhiro Nakamura, Aya Fujimoto, Toshiya Masuda, Ken Nakano and Hiyoshizo Kotsuki :
Synthesis of manzacidin A and C: efficient construction of quarternary carbon stereocenters bearing nitrogen substituents,
Organic & Biomolecular Chemistry, Vol.10, No.3, 614-622, 2012.
(DOI: 10.1039/c1ob06559a,   PubMed: 22113586)
6.Yoshimi Shingai, Aya Fujimoto, Mitsuhiro Nakamura and Toshiya Masuda :
Structure and function of the oxidation products of polyphenols and identification of potent lipoxygenase inhibitors from fe-catalyzed oxidation of resveratrol.,
Journal of Agricultural and Food Chemistry, Vol.59, No.15, 8180-8186, 2011.
(DOI: 10.1021/jf202561p,   PubMed: 21726087)
7.Yoshiyasu Ichikawa, Yasunori Matsuda, Ken Okumura, Mitsuhiro Nakamura, Toshiya Masuda, Hiyoshizo Kotsuki and Keiji Nakano :
Asymmetric synthesis of (+)-geranyllinaloisocyanide: assignment of absolute stereochemistry.,
Organic Letters, Vol.13, No.10, 2520-2523, 2011.
(DOI: 10.1021/ol200308m,   PubMed: 21491897)
8.Aya Fujimoto, Yoshimi Shingai, Mitsuhiro Nakamura, Tomomi Maekawa, Yoshiaki Sone and Toshiya Masuda :
A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol,
Bioorganic & Medicinal Chemistry Letters, Vol.20, No.24, 7393-7396, 2010.
(DOI: 10.1016/j.bmcl.2010.10.040,   PubMed: 21041086)
9.Toshiya Masuda, Yoshimi Shingai, Aya Fujimoto, Mitsuhiro Nakamura, Yasuo Oyama, Tomomi Maekawa and Yoshiaki Sone :
Identification of cytotoxic dimers in oxidation product from sesamol, a potent antioxidant of sesame oil,
Journal of Agricultural and Food Chemistry, Vol.58, No.20, 10880-10885, 2010.
(DOI: 10.1021/jf103015j,   PubMed: 20925385)
10.Yexi Chen, Yuki Yamaguchi, Yuta Tsugeno, Junichi Yamamoto, Tomoko Yamada, Mitsuhiro Nakamura, Koji Hisatake and Hiroshi Handa :
DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation,
Genes & Development, Vol.23, No.23, 2765-2777, 2009.
(DOI: 10.1101/gad.1834709,   PubMed: 19952111)
11.Yoko Ohashi, Masayuki Kubota, Hiroshi Hatase, Mitsuhiro Nakamura, Takashi Hirano, Haruki Niwa and Yoshitaka Nagai :
Distinction of Sialyl Anomers on ESI- and FAB-MS/MS: Stereo-Specific Fragmentations,
Journal of the American Society for Mass Spectrometry, Vol.20, No.3, 394-397, 2009.
(DOI: 10.1016/j.jasms.2008.10.020)
12.Jinsuk Kang, Matthew Gemberling, Mitsuhiro Nakamura, FrankG. Whitby, Hiroshi Handa, WilliamG. Fairbrother and Dean Tantin :
A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress,
Genes & Development, Vol.23, No.2, 208-222, 2009.
(DOI: 10.1101/gad.1750709,   PubMed: 19171782)
13.Masafumi Suzuki, Shoichiro Furukawa, Chikanori Kuramori, Chika Sawa, Yasuaki Kabe, Mitsuhiro Nakamura, Jun-ichi Sawada, Yuki Yamaguchi, Satoshi Sakamoto, Satoshi Inouye and Hiroshi Handa :
Development of a chemical screening system using aqueorin-fused protein,
Biochemical and Biophysical Research Communications, Vol.368, No.3, 600-605, 2008.
(DOI: 10.1016/j.bbrc.2008.01.107,   PubMed: 18243129)
14.Kazuki Niwa, Mitsuhiro Nakamura and Yoshihiro Ohmiya :
Stereoisomeric bio-inversion key to biosynthesis of firefly D-luciferin,
FEBS Letters, Vol.580, No.22, 5283-5287, 2006.
(DOI: 10.1016/j.febslet.2006.08.073,   PubMed: 16979628)
15.Mitsuhiro Nakamura, Kazuki Niwa, Shojiro Maki, Takashi Hirano, Yoshihiro Ohmiya and Haruki Niwa :
Construction of a new firefly bioluminescence system using L-luciferin as substrate,
Tetrahedron Letters, Vol.47, No.7, 1197-1200, 2006.
(DOI: 10.1016/j.tetlet.2005.12.033)
16.Mitsuhiro Nakamura, Takahiko Kakuda, Jianhua Qi, Masayuki Hirata, Tomoaki Shintani, Yukio Yoshioka, Tetsuji Okamoto, Yuichi Oba, Hideshi Nakamura and Makoto Ojika :
Novel relationship beween the antifungal activity and cytotoxicity of marine-derived methabolite xestoquinone and its family,
Bioscience, Biotechnology, and Biochemistry, Vol.69, No.9, 1749-1752, 2005.
(DOI: 10.1271/bbb.69.1749,   PubMed: 16195594)
17.Mitsuhiro Nakamura, Shojiro Maki, Yoshiharu Amano, Yutaka Ohkita, Kazuki Niwa, Takashi Hirano, Yoshihiro Ohmiya and Haruki Niwa :
Firefly luciferase exhibits bimodal action depending on the luciferin chirality,
Biochemical and Biophysical Research Communications, Vol.331, No.2, 471-475, 2005.
(DOI: 10.1016/j.bbrc.2005.03.202,   PubMed: 15850783)
18.Yoko Ohashi, Hiroshi Hatase, Mitsuhiro Nakamura, Takashi Hirano, Shojiro Maki and Haruki Niwa :
Characterization of [1-13C]-specifically labeled amino acids using ESIMS/MS in the selected reaction monitoring mode mode.,
Journal of the Mass Spectrometry Society of Japan, Vol.53, No.6, 309-314, 2005.
(DOI: 10.5702/massspec.53.309,   CiNii: 10017073391)
19.Mitsuhiro Nakamura, Masashi Mamino, Mizuki Masaki, Shojiro Maki, Ryo Matsui, Satoshi Kojima, Takashi Hirano, Yoshihiro Ohmiya and Haruki Niwa :
Bioluminescence activity of Latia luciferin analogues: Replacement of the 2,6,6-trimethylcyclohexene ring onto the methyl-substituted phenyl groups,
Tetrahedron Letters, Vol.46, No.1, 53-56, 2005.
(DOI: 10.1016/j.tetlet.2004.11.043)
20.Mitsuhiro Nakamura, Yukisato Ishida, Toshiyuki Kohno, Kazuki Sato, Yuichi Oba and Hideshi Nakamura :
Effects of modification at the fifth residue of mu-conotoxin GIIIA with bulky tags on the electrically stimulated contraction of the rat diaphragm,
The Journal of Peptide Research, Vol.64, 110-117, 2004.
(DOI: 10.1111/j.1399-3011.2004.00175.x,   PubMed: 15317501)
21.Mitsuhiro Nakamura, Mizuki Masaki, Shojiro Maki, Ryo Matsui, Minako Hieda, Masashi Mamino, Takashi Hirano, Yoshihiro Ohmiya and Haruki Niwa :
Synthesis of Latia luciferin benzoate analogues and their bioluminescent activity,
Tetrahedron Letters, Vol.45, 2203-2205, 2004.
(DOI: 10.1016/j.tetlet.2004.01.027)
22.Mitsuhiro Nakamura, Takahiko Kakuda, Yuichi Oba, Makoto Ojika and Hideshi Nakamura :
Synthesis of Biotinylated Xestoquinone That Retains Inhibitory Activity Against Ca2+ ATPase of Skeletal Muscle Myosin,
Bioorganic & Medicinal Chemistry, Vol.11, 3077-3082, 2003.
(DOI: 10.1016/S0968-0896(03)00276-1,   PubMed: 12818670)
23.Chieko Nakada, Kenneth Ritchie, Yuichi Oba, Mitsuhiro Nakamura, Yoko Hotta, Ryota Iino, RinshiS. Kasai, Kazuhiko Yamaguchi, Satoshi Sakamoto, Takahiro Fujiwara and Akihiro Kusumi :
Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization,
Nature Cell Biology, Vol.5, No.7, 626-632, 2003.
(DOI: 10.1038/ncb1009,   PubMed: 12819789)
24.Satoshi Inouye and Mitsuhiro Nakamura :
Identification of biotinylated lysine residues in the photoprotein aequorin by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry peptide mapping after lysine-specific endopeptidase digestion,
Analytical Biochemistry: Methods in the Biological Sciences, Vol.316, No.2, 216-222, 2003.
(DOI: 10.1016/S0003-2697(03)00055-1,   PubMed: 12711343)
25.Atsunori Furuhata, Mitsuhiro Nakamura, Toshihiko Osawa and Koji Uchida :
Thiolation of protein-bound carcinogenic aldehyde: An electrophilic acrolein-lysine adduct that covalently binds to thiols,
The Journal of Biological Chemistry, Vol.277, No.31, 27919-27926, 2002.
(DOI: 10.1074/jbc.M202794200,   PubMed: 12032148)
26.Mitsuhiro Nakamura, Yuichi Oba, Tatsuya Mori, Kazuki Sato, Yukisato Ishida, Tsukasa Matsuda and Hideshi Nakamura :
Generation of Polyclonal Antibody against mu-Conotoxin GIIIA Using an Immunogen of [Cys5]mu-Conotoxin GIIIA Site-Specifically Conjugated with Bovine Serum Albumin,
Biochemical and Biophysical Research Communications, Vol.290, No.3, 1037-1041, 2002.
(DOI: 10.1006/bbrc.2001.6276,   PubMed: 11798179)
27.Mitsuhiro Nakamura, Yukari Niwa, Yukisato Ishida, Toshiyuki Kohno, Kazuki Sato, Yuichi Oba and Hideshi Nakamura :
Modification of Arg-13 of mu-conotoxin GIIIA with piperidinyl-Arg analogs and the relation to the inhibition of sodium channels,
FEBS Letters, Vol.503, No.1, 107-110, 2001.
(DOI: 10.1016/S0014-5793(01)02714-4,   PubMed: 11513864,   Elsevier: Scopus)
28.Mitsuhiro Nakamura, Yukisato Ishida, Toshiyuki Kohno, Kazuki Sato and Hideshi Nakamura :
Synthesis of [Cys5]mu-conotoxin GIIIA and its derivatives as a probe of Na+ channel analysis,
Biochemical and Biophysical Research Communications, Vol.283, 374-378, 2001.
(DOI: 10.1006/bbrc.2001.4800,   PubMed: 11327711,   Elsevier: Scopus)

Academic Paper (Unrefereed Paper):

1.Mitsuhiro Nakamura, Yuichi Oba, Kazuki Sato, Yukisato Ishida, Tsukasa Matsuda and Hideshi Nakamura :
Generation of polyclonal antibody against peptide toxin mu-conotoxin GIIIA and their characterizations,
Peptide Science 2001 (Aoyagi, H. Ed.), 385-386, 2002.
2.Mitsuhiro Nakamura, Yukari Niwa, Yukisato Ishida, Toshiyuki Kohno, Kazuki Sato, Yuichi Oba and Hideshi Nakamura :
Modification to Arg-13 of mu-conotoxin GIIIA with piperidinyl-Arg analogs and their evaluations,
Peptide Science 2001 (Aoyagi, H. Ed.), 203-204, 2002.
3.Mitsuhiro Nakamura, Yukisato Ishida, Toshiyuki Kohno, Kazuki Sato and Hideshi Nakamura :
Syntheses and activity of mu-conotoxin analogs with a modified amino acid,
Peptide Science 2000 (Shioiri, T. Ed.), Vol.283, 85-88, 2001.

Review, Commentary:

1.畠山 士, 西尾 広介, Mitsuhiro Nakamura, 坂本 聡, 加部 泰明, 和田 忠士 and 半田 宏 :
,
, 9-20, Jan. 2007.
2.Yoshihiro Ohmiya, Satoshi Kojima, Mitsuhiro Nakamura and Haruki Niwa :
Bioluminescence in the Limpet-Like Snail, Latia neritoides,
Bulletin of the Chemical Society of Japan, Vol.78, No.7, 1197-1205, Jul. 2005.
(DOI: 10.1246/bcsj.78.1197,   CiNii: 10016579853)
3.Mitsuhiro Nakamura :
,
Chemistry & Chemical Industry, Vol.57, No.2, 123-126, Feb. 2004.

Proceeding of International Conference:

1.Aya Fujimoto, Yoshimi Shingai, Mitsuhiro Nakamura, Tomomi Maekawa, Sone Yoshiaki and Toshiya Masuda :
POLYPHENOL OXIDATION, STRUCTURE AND FUNCTION OF THE PRODUCT I.TYROSINASE INHIBITORY OXIDATION PRODUCTS FROM ROSMARINIC ACID,
International Conference of Food Factor 2011, Taipei, Nov. 2011.
2.Yoshimi Shingai, Aya Fujimoto, Mitsuhiro Nakamura and Toshiya Masuda :
Polyphenol Oxidation,Structure and Function of the Product II.LC-MS Investigation of Lipoxygenase Inhibitory Products of Resveratrol Oxidation,
International Conference of Food Factor 2011, Taipei, Nov. 2011.

Proceeding of Domestic Conference:

1.Mitsuhiro Nakamura, 中原 舞 and 松田 和生 :
,
, Nov. 2017.
2.Mitsuhiro Nakamura :
,
, Nov. 2013.
3.Mitsuhiro Nakamura :
,
, Oct. 2012.
4.Aya Fujimoto, Miyuki Inai, Mitsuhiro Nakamura and Toshiya Masuda :
,
, Mar. 2012.
5.Yoshimi Shingai, Aya Fujimoto, Mitsuhiro Nakamura and Toshiya Masuda :
,
, Jan. 2012.
6.Yoshimi Shingai, Aya Fujimoto, Yasuo Oyama, Mitsuhiro Nakamura, 前川 智美, 曽根 良昭 and Toshiya Masuda :
,
, 277-282, Sep. 2011.
7.Mitsuhiro Nakamura :
,
, Sep. 2011.
8.新開 愛美, Aya Fujimoto, Mitsuhiro Nakamura and Toshiya Masuda :
,
, Mar. 2011.
9.Aya Fujimoto, 新開 愛美, Mitsuhiro Nakamura and Toshiya Masuda :
,
, Mar. 2011.
10.Aya Fujimoto, 新開 愛美, Mitsuhiro Nakamura and Toshiya Masuda :
,
, 475-480, Sep. 2010.
11.新開 愛美, Aya Fujimoto, Mitsuhiro Nakamura, Toshiya Masuda and Yasuo Oyama :
,
, 62, Sep. 2010.

Patent:

1.Yoshihiro Ohmiya, Kazuki Niwa, Haruki Niwa, Mitsuhiro Nakamura and Masayuki Ryufuku : SYSTEM FOR BIOSYNTHESIS OF FIREFLY LUMINESCENCE SUBSTRATES WITH NATURAL L-CYSTEINE OR DERIVATIVES THEREOF AND LUMINESCENCE SUBSTRATE SOLUTIONS CONTAINING THE SYSTEM, PCT/JP2005/23847 (Dec. 2005), WO/2006/070775 (Jul. 2006), WO/2006/070775 (Jul. 2006).
2.近江谷 克裕, 丹羽 一樹, 丹羽 治樹, Mitsuhiro Nakamura and 龍福 正行 : , 2004-379971 (Dec. 2004), 2006-180825 (Jul. 2006), 2006-180825 (Jul. 2006).
3.中村 英士, 大場 裕一 and Mitsuhiro Nakamura : , 2001-66198 (Mar. 2001), 2001-322999 (Nov. 2001), 2001-322999 (Nov. 2001).

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)