Tokushima University / Educator and Researcher Directory --- Kinoshita, Michiko

Personal Web Page

https://orcid.org/0000-0001-8680-7654 (ORCID)

Field of Study

○	Medicine

Subject of Study

○

Book / Paper

Academic Paper (Judged Full Paper):

1.	Michiko Kinoshita, Suzuki Nao and Katsuya Tanaka : Trends and Factors Affecting the Number of Abstracts at the Annual Meeting of the Japanese Society of Anesthesiologists, Masui, Vol.73, No.4, 233-237, 2024.
2.	Sarara Mutoh, Michiko Kinoshita, Yuki Maeda and Katsuya Tanaka : Ketamine as an Alternative Anesthetic for Augmenting Seizure Durations During Electroconvulsive Therapy: A Retrospective Observational Study, The Journal of ECT, 2023. (Summary) Electroconvulsive therapy (ECT) is highly effective for severe psychiatric disorders; however, short seizure durations may lead to ineffective therapy. This retrospective study aimed to examine the risks and benefits of switching to ketamine anesthesia to augment seizure durations during an acute course of ECT. We included 33 patients who underwent ketamine anesthesia due to suboptimal seizures during an acute course of ECT. We assessed seizure duration, stimulus dose, hemodynamic variability, and postseizure complications before and after switching to ketamine. Age was significantly associated with suboptimal seizures during ECT (P = 0.040). After switching to ketamine, 32 patients (97%) experienced prolonged seizure duration. Ketamine significantly prolonged both electroencephalogram and motor seizure durations with a mean difference of 34.6 seconds (95% confidence interval [CI], 26.4-42.7 seconds; P < 0.001) and 26.6 seconds (95% CI, 19.6-33.6 seconds; P < 0.001), respectively. It also significantly reduced stimulus dose (mean difference, -209.5 mC [95% CI, -244.9 to -174.1 mC]; P < 0.001). In addition, maximum changes in systolic blood pressure and heart rate during ECT sessions significantly increased with ketamine (mean difference, 27.2 mm Hg [95% CI, 12.0-42.4 mm Hg; P = 0.001]; 25.7 beats per minute [95% CI, 14.5-36.8 beats per minute; P < 0.001], respectively). Patients reported more headaches with ketamine (P = 0.041). Our results provide evidence that ketamine as an alternative anesthetic can augment seizure durations in specific patients experiencing suboptimal seizures during an acute course of ECT. However, its use requires greater attention to circulatory management and postseizure complications. (Keyword) augmentation / alternative anesthetic / electroconvulsive therapy / ketamine / seizure duration (Tokushima University Institutional Repository) ● Metadata: 118832 (Link to Publication Site) ● Publication site (DOI): 10.1097/YCT.0000000000000981 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38109337 ● Search Scopus @ Elsevier (PMID): 38109337 ● Search Scopus @ Elsevier (DOI): 10.1097/YCT.0000000000000981 (Tokushima University Institutional Repository: 118832, DOI: 10.1097/YCT.0000000000000981, PubMed: 38109337)
3.	Michiko Kinoshita, Makoto Kinoshita, Rikako Takahashi, Sarara Mutoh, Nami Kakuta and Katsuya Tanaka : The Safety and Strategies for Reinitiating Electroconvulsive Therapy After ECT-Induced Takotsubo Cardiomyopathy: A Case Report and Systematic Review., The Journal of ECT, Vol.39, No.3, 185-192, 2023. (Summary) Electroconvulsive therapy-induced TCM is more likely to cause cardiogenic shock than nonperioperative cases; nevertheless, it has good prognosis. Cautious reinitiation of ECT after TCM recovery is possible. Further studies are required to determine preventive measures for ECT-induced TCM. (Keyword) electroconvulsive therapy / takotsubo cardiomyopathy / systematic review (Tokushima University Institutional Repository) ● Metadata: 118060 (Link to Publication Site) ● Publication site (DOI): 10.1097/YCT.0000000000000905 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36897138 ● Summary page in Scopus @ Elsevier: 2-s2.0-85169185042 (Tokushima University Institutional Repository: 118060, DOI: 10.1097/YCT.0000000000000905, PubMed: 36897138, Elsevier: Scopus)
4.	Yuta Uemura, Michiko Kinoshita, Yoko Sakai and Katsuya Tanaka : Hemodynamic impact of ephedrine on hypotension during general anesthesia: a prospective cohort study on middle-aged and older patients, BMC Anesthesiology, Vol.23, No.1, 283, 2023. (Summary) Ephedrine is a mixed α- and β-agonist vasopressor that is frequently used for the correction of hypotension during general anesthesia. β-responsiveness has been shown to decrease with age; therefore, this study aimed to determine whether aging would reduce the pressor effect of ephedrine on hypotension during general anesthesia. Seventy-five patients aged ≥ 45 years were included in this study, with 25 patients allocated to each of the three age groups: 45-64 years, 65-74 years, and ≥ 75 years. All patients received propofol, remifentanil, and rocuronium for the induction of general anesthesia, followed by desflurane and remifentanil. Cardiac output (CO) was estimated using esCCO technology. Ephedrine (0.1 mg/kg) was administered for the correction of hypotension. The primary and secondary outcome measures were changes in the mean arterial pressure (MAP) and CO, respectively, at 5 min after the administration of ephedrine. RESULTS: The administration of ephedrine significantly increased MAP (p < 0.001, mean difference: 8.34 [95% confidence interval (CI), 5.95-10.75] mmHg) and CO (p < 0.001, mean difference: 7.43 [95% CI, 5.20-9.65] %) across all groups. However, analysis of variance revealed that the degree of elevation of MAP (F [2, 72] = 0.546, p = 0.581, η = 0.015 [95% CI, 0.000-0.089]) and CO (F [2, 72] = 2.023, p = 0.140, η = 0.053 [95% CI, 0.000-0.162]) did not differ significantly among the groups. Similarly, Spearman's rank correlation and multiple regression analysis revealed no significant relation between age and the changes in MAP or CO after the administration of ephedrine. The administration of ephedrine significantly increased MAP and CO; however, no significant correlation with age was observed in patients aged > 45 years. These findings suggest that ephedrine is effective for the correction of hypotension during general anesthesia, even in elderly patients. UMIN-CTR (UMIN000045038; 02/08/2021). (Keyword) Aged / Middle Aged / Humans / Ephedrine / Prospective Studies / Remifentanil / Hemodynamics / Hypotension / Vasoconstrictor Agents / Anesthesia, General (Tokushima University Institutional Repository) ● Metadata: 118532 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12871-023-02244-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37608253 ● Summary page in Scopus @ Elsevier: 2-s2.0-85168706206 (Tokushima University Institutional Repository: 118532, DOI: 10.1186/s12871-023-02244-4, PubMed: 37608253, Elsevier: Scopus)
5.	Michiko Kinoshita, Yoko Sakai and Katsuya Tanaka : Relative publication output and international collaboration in anaesthesiology and pain medicine: a bibliometric analysis from 1996 to 2021, British Journal of Anaesthesia, Vol.131, No.2, e53-e55, 2023. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bja.2023.05.014 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37330311 ● Summary page in Scopus @ Elsevier: 2-s2.0-85165099943 (DOI: 10.1016/j.bja.2023.05.014, PubMed: 37330311, Elsevier: Scopus)
6.	Michiko Kinoshita, Takahashi Mina, Katsuya Tanaka and Yoko Sakai : Authorship by gender in anesthesiology journals: a retrospective cross-sectional study for Japan, Journal of Anesthesia, Vol.37, No.3, 364-370, 2023. (Summary) Although it is important to recognize gender disparities in publishing to achieve gender diversity, women's authorship in Japan remains unclear. Therefore, this study aimed to investigate the percentage and analyze the trends of articles authored and published in anesthesiology journals by Japanese female authors. The genders of the first and last authors affiliated with Japanese institutions were surveyed in the Journal of Anesthesia (JA) (1990, 1995, and 2000-2022) and 11 international anesthesiology journals (2010-2022). We included 845 and 819 original research articles from JA in the analyses of the first and last authors, respectively. The proportion of female first authors significantly increased from 41 (11.7%) out of 351 before 2009 to 119 (24.1%) out of 494 after 2010 (p < 0.001). The proportion of female last authors was 11 (3.3%) out of 335 before 2009 and 22 (4.5%) out of 484 after 2010, respectively, with no significant difference (p = 0.470). We included 624 and 572 original research articles from international anesthesiology journals in the analyses of first and last authors, respectively. Among these, there were 134 (21.5%) and 23 (4.0%) female first and last authors, respectively. These proportions in international anesthesiology journals did not significantly differ from those in JA (p = 0.334, p = 0.789, respectively). The percentage of female first authors has increased, commensurate with the percentage of female anesthesiologists. However, the percentage of female last authors has not increased and remains low in Japan. (Tokushima University Institutional Repository) ● Metadata: 117926 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00540-023-03165-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36688988 ● Search Scopus @ Elsevier (PMID): 36688988 ● Search Scopus @ Elsevier (DOI): 10.1007/s00540-023-03165-9 (Tokushima University Institutional Repository: 117926, DOI: 10.1007/s00540-023-03165-9, PubMed: 36688988)
7.	Ryo Sekiguchi, Michiko Kinoshita, Ryosuke Kawanishi, Nami Kakuta, Yoko Sakai and Katsuya Tanaka : Comparison of hemodynamics during induction of general anesthesia with remimazolam and target-controlled propofol in middle-aged and elderly patients: a single-center, randomized, controlled trial., BMC Anesthesiology, 2023. (Summary) UMIN-CTR (UMIN000045612). (Keyword) Adult / Aged / Middle Aged / Humans / Propofol / Piperidines / Hemodynamics / Anesthesia, General / Hypotension / Unconsciousness / Anesthetics, Intravenous (Tokushima University Institutional Repository) ● Metadata: 117916 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12871-023-01974-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36624371 ● Search Scopus @ Elsevier (PMID): 36624371 ● Search Scopus @ Elsevier (DOI): 10.1186/s12871-023-01974-9 (Tokushima University Institutional Repository: 117916, DOI: 10.1186/s12871-023-01974-9, PubMed: 36624371)
8.	Michiko Kinoshita, Sarara Mutoh, Asuka Kasai, Ryosuke Kawanishi and Katsuya Tanaka : General Anesthesia in a Patient With Neuronal Intranuclear Inclusion Disease: A Case Report., A&A Practice, Vol.16, No.10, 2022. (Summary) Neuronal intranuclear inclusion disease (NIID) is a progressive neurodegenerative disease with diverse clinical manifestations, including dementia and muscle weakness. We summarize anesthetic considerations in reporting general anesthesia for a 58-year-old man with bladder dysfunction and cerebellar ataxia who was diagnosed with NIID. The patient developed postinduction hypotension relevant to autonomic neuropathy. The potential risks, such as prolonged reaction to neuromuscular blocking agent, postoperative delirium, and worsening of NIID-related symptoms, were also considered. The responsiveness to anesthetics may vary widely from case t case. As the number of NIID cases increases, a better understanding of NIID is needed. (Link to Publication Site) ● Publication site (DOI): 10.1213/XAA.0000000000001633 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36599032 ● Search Scopus @ Elsevier (PMID): 36599032 ● Search Scopus @ Elsevier (DOI): 10.1213/XAA.0000000000001633 (DOI: 10.1213/XAA.0000000000001633, PubMed: 36599032)
9.	Michiko Kinoshita, Yoko Sakai, Kimiko Katome, Tomomi Matsumoto, Shizuka Sakurai, Yuka Jinnouchi and Katsuya Tanaka : Transition in eye gaze as a predictor of emergence from general anesthesia in children and adults: a prospective observational study., BMC Anesthesiology, Vol.22, No.1, 2022. (Summary) In children, eye-gaze transition was observed significantly earlier than other physical-behavioral responses during emergence from general anesthesia and seemed to reflect emergence from anesthesia. In contrast, observation of eye gaze was not a useful indicator of emergence from anesthesia in adults. (Tokushima University Institutional Repository) ● Metadata: 117915 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12871-022-01867-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36253763 ● Search Scopus @ Elsevier (PMID): 36253763 ● Search Scopus @ Elsevier (DOI): 10.1186/s12871-022-01867-3 (Tokushima University Institutional Repository: 117915, DOI: 10.1186/s12871-022-01867-3, PubMed: 36253763)
10.	Michiko Kinoshita, Yuki Ishikawa, Ryo Sekiguchi, Miyuki Matsuda and Katsuya Tanaka : Impact of surgical masks on fraction of inspired oxygen during oxygen therapy depends on the type of oxygen masks and respiratory conditions: volunteer- and simulation-based studies., Journal of Anesthesia, Vol.36, No.5, 633-641, 2022. (Summary) during oxygen therapy with oxygen masks. The impact of SM depended on the type of the oxygen mask, mask fitting, and respiratory condition. (Keyword) Carbon Dioxide / Humans / Masks / Oxygen / Oxygen Inhalation Therapy / Respiratory Rate / Volunteers (Tokushima University Institutional Repository) ● Metadata: 117917 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00540-022-03083-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35711009 ● Search Scopus @ Elsevier (PMID): 35711009 ● Search Scopus @ Elsevier (DOI): 10.1007/s00540-022-03083-2 (Tokushima University Institutional Repository: 117917, DOI: 10.1007/s00540-022-03083-2, PubMed: 35711009)
11.	Michiko Kinoshita, Yasuhito Honda, Yoko Sakai, Yoshinobu Tomiyama and Katsuya Tanaka : Elevated tryptase in vancomycin-induced red man syndrome., Journal of Anesthesia, Vol.35, No.5, 773-774, 2021. (Keyword) Erythema / Humans / syndrome / Tryptases / Vancomycin (Link to Publication Site) ● Publication site (DOI): 10.1007/s00540-021-02985-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34387746 ● Summary page in Scopus @ Elsevier: 2-s2.0-85112453285 (DOI: 10.1007/s00540-021-02985-x, PubMed: 34387746, Elsevier: Scopus)
12.	Chiaki Murakami, Hiroaki Kawano, Michiko Kinoshita, Akio Kondo and Masaya Inoue : Effects of Nicorandil Versus Nitroglycerin on Arterial Oxygenation During Two-Lung Ventilation and One-Lung Ventilation in Patients With Risk Factors for Myocardial Ischemia: A Prospective, Randomized, Double-Blind Study., Journal of Cardiothoracic and Vascular Anesthesia, Vol.33, No.3, 702-709, 2018. (Summary) This study demonstrated that oxygenation during TLV and OLV was significantly higher in patients receiving nicorandil than in those receiving nitroglycerin. (Link to Publication Site) ● Publication site (DOI): 10.1053/j.jvca.2018.05.022 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30054187 ● Search Scopus @ Elsevier (PMID): 30054187 ● Search Scopus @ Elsevier (DOI): 10.1053/j.jvca.2018.05.022 (DOI: 10.1053/j.jvca.2018.05.022, PubMed: 30054187)
13.	Hiroaki Kawano, Michiko Kinoshita, Akio Kondo, Yasuhito Yamada and Masaya Inoue : TORSADES DE POINTES ASSOCIATED WITH TAKOTSUBO CARDIOMYOPATHY IN AN ANOREXIA NERVOSA PATIENT DURING EMERGENCE FROM GENERAL ANESTHESIA., Middle East Journal of Anaesthesiology, Vol.23, No.5, 557-561, 2016. (Summary) Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy, is a disease in which the patient exhibits transient, reversible left ventricular dysfunction that is triggered by physical or emotional stress. Prolongation of QT interval, a risk factor for arrhythmia and sudden death, has been reported to be prevalent among patients with Takotsubo cardiomyopathy and is also observed in those with severe anorexia nervosa. In this report, we describe the rare case of a 30-year-old female patient with anorexia nervosa who developed Torsades de Pointes associated with Takotsubo cardiomyopathy during emergence from general anesthesia for emergency exploratory laparotomy. (Keyword) Adult / Anesthesia, General / Anorexia Nervosa / Electrocardiography / Female / Humans / Laparotomy / Takotsubo Cardiomyopathy / Torsades de Pointes (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27487642 ● Search Scopus @ Elsevier (PMID): 27487642 (PubMed: 27487642)
14.	Michiko Kinoshita, Yasuo M. Tsutsumi, Kohei Fukuta, Asuka Kasai and Katsuya Tanaka : Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels., The Journal of Medical Investigation : JMI, Vol.63, No.1-2, 80-84, 2016. (Summary) Activation of the mitochondrial calcium-activated potassium (mKCa) channel reportedly confers resistance to myocardial ischemic stress. However, the role of the mKCa channel in postconditioning induced by volatile anesthetic remains unclear. Male Japanese white rabbits underwent coronary artery occlusion for 30 min followed by reperfusion for 3 h. Volatile anesthetic, isoflurane, was administered at 3 min prior to reperfusion for 5 min. Rabbits were injected with the mKCa channel blocker, iberiotoxin, or the mKCa channel opener, NS1619, at 8 min prior to reperfusion. Myocardial infarct size and the area at risk (AAR) were measured at the end of the experiment. Isoflurane significantly reduced infarct size (23.0 ± 9.8% of the AAR, P<0.05) compared with the control (44.0 ± 9.1%). Iberiotoxin abolished the cardioprotective impact of isoflurane (43.0 ± 11.6%), while iberiotoxin alone exerted no effect on infarct size (45.0 ± 9.5%). NS1619 and isoflurane/NS1619 both significantly reduced infarct size (21.0 ± 10.3% and 19.0 ± 8.8%, respectively, P<0.05 vs control group), but isoflurane/NS1619 showed no additional benefits compared with isoflurane alone. These results indicate that activation of the mKCa channel contribute isoflurane-induced postconditioning. (Tokushima University Institutional Repository) ● Metadata: 111158 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.63.80 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27040058 ● Summary page in Scopus @ Elsevier: 2-s2.0-84962157655 (Tokushima University Institutional Repository: 111158, DOI: 10.2152/jmi.63.80, PubMed: 27040058, Elsevier: Scopus)
15.	Hiroaki Kawano, Naohiro Ohshita, Kimiko Katome, Takako Kadota, Michiko Kinoshita, Yayoi Matsuoka, Yasuo M. Tsutsumi, Shinji Kawahito, Katsuya Tanaka and Shuzo Oshita : [Effects of a novel method of anesthesia combining propofol and volatile anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery]., Revista Brasileira de Anestesiologia, Vol.66, No.1, 12-18, 2015. (Summary) We investigated the effects of a novel method of anesthesia combining propofol and volatile anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery. Patients were randomly divided into three groups: those maintained with sevoflurane (Group S; n = 42), propofol (Group P; n = 42), or combined propofol and sevoflurane (Group PS; n = 42). We assessed complete response (no postoperative nausea and vomiting and no rescue antiemetic use), incidence of nausea and vomiting, nausea severity score, vomiting frequency, rescue antiemetic use, and postoperative pain at 2 and 24h after surgery. The number of patients who exhibited a complete response was greater in Groups P and PS than in Group S at 0-2h (74%; 76% and 43%; respectively, p = 0.001) and 0-24h (71%; 76%, and 38%; respectively, p < 0.0005). The incidence of nausea at 0-2h (Group S = 57%; Group P = 26% and Group PS = 21%; p = 0.001) and 0-24h (Group S = 62%; Group P = 29% and Group PS = 21%; p < 0.0005) was also significantly different among groups. However, there were no significant differences among groups in the incidence or frequency of vomiting or rescue antiemetic use at 0-24h. Combined propofol and volatile anesthesia during laparoscopic gynecological surgery effectively decreases the incidence of postoperative nausea. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bjan.2014.07.006 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25896644 ● Summary page in Scopus @ Elsevier: 2-s2.0-84952982793 (DOI: 10.1016/j.bjan.2014.07.006, PubMed: 25896644, Elsevier: Scopus)
16.	Hiroaki Kawano, Sawa Manabe, Tomomi Matsumoto, Eisuke Hamaguchi, Michiko Kinoshita, Fumihiko Tada and Shuzo Oshita : Comparison of intraoperative blood loss during spinal surgery using either remifentanil or fentanyl as an adjuvant to general anesthesia., BMC Anesthesiology, Vol.13, No.1, 2013. (Summary) Intraoperative blood loss during spinal surgery was decreased in patients who received remifentanil as an opioid adjuvant, possibly because of lower intraoperative BP. A larger-scale prospective randomized controlled trial is warranted to confirm our results and to test whether remifentanil can decrease intraoperative blood loss during other surgical procedures. (Link to Publication Site) ● Publication site (DOI): 10.1186/1471-2253-13-46 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24304964 ● Search Scopus @ Elsevier (PMID): 24304964 ● Search Scopus @ Elsevier (DOI): 10.1186/1471-2253-13-46 (DOI: 10.1186/1471-2253-13-46, PubMed: 24304964)
17.	Kayo Hirose, Yasuo M. Tsutsumi, Rie Tsutsumi, Masayuki Shono, Erika Katayama, Michiko Kinoshita, Katsuya Tanaka and Shuzo Oshita : Role of the O-linked -N-acetylglucosamine in the cardioprotection induced by isoflurane., Anesthesiology, Vol.115, No.5, 955-962, 2011. (Summary) Cardiac protection by volatile anesthetic-induced preconditioning and ischemic preconditioning have similar signaling pathways. Recently, it was reported that augmentation of protein modified with O-linked -N-acetylglucosamine (O-GlcNAc) contributes to cardiac protection. This study investigated the role of O-GlcNAc in cardiac protection induced by anesthetic-induced preconditioning. O-GlcNAc-modified proteins were visualized by immunoblotting. Tolerance against ischemia or reperfusion was tested in vivo (n = 8) and in vitro (n = 6). The opening of the mitochondrial permeability transition pore (mPTP) upon oxidative stress was examined in myocytes treated with calcein AM (n = 5). Coimmunoprecipitation and enzymatic labeling were performed to detect the mitochondrial protein responsible for the mPTP opening. Isoflurane treatment and the consequent augmentation of O-GlcNAc concentrations reduced the infarct size (26 ± 5% [mean ± SD], P < 0.001) compared with the control. The protective effect of O-GlcNAc was eliminated in the group pretreated with the O-GlcNAc transferase inhibitor alloxan (39 ± 5%, P < 0.001). Myocyte survival also showed the same result in vitro. Formation of the mPTP was abrogated in the isoflurane-treated cells (86 ± 4%, P < 0.001) compared with the control and alloxan-plus-isoflurane-treated cells (57 ± 7%, P < 0.001). Coimmunoprecipitation and enzymatic labeling studies revealed that the O-GlcNAc-modified, voltage-dependent anion channel restained the mPTP opening. Isoflurane induced O-GlcNAc modification of mitochondrial voltage-dependent anion channel. This modification inhibited the opening of the mPTP and conferred resistance to ischemia-reperfusion stress. (Keyword) Acetylglucosamine / Anesthetics, Inhalation / Animals / Cell Survival / Heart / Ischemic Preconditioning, Myocardial / Isoflurane / Male / Mice / Mice, Inbred C57BL / Mitochondrial Membrane Transport Proteins / Myocardial Reperfusion Injury / Voltage-Dependent Anion Channels (Link to Publication Site) ● Publication site (DOI): 10.1097/ALN.0b013e31822fcede (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21876430 ● Search Scopus @ Elsevier (PMID): 21876430 ● Search Scopus @ Elsevier (DOI): 10.1097/ALN.0b013e31822fcede (DOI: 10.1097/ALN.0b013e31822fcede, PubMed: 21876430)
18.	Kouhei Fukuta, Yasuo Tsutsumi, Tomohiro Soga, Michiko Kinoshita and Katsuya Tanaka : Emergency Anesthesia in a Patient with von Hippel-Lindau Syndrome Who Underwent Pheochromocytectomy and the Resection of Cerebellar Hemangioblastoma, The Journal of Japan Society for Clinical Anesthesia, Vol.31, No.5, 884-887, 2011. (Keyword) von Hippel-Lindau syndrome / Pheochromocytoma / Cerebellar hemangioblastoma / High dose remifentanil / Emergency surgery (Tokushima University Institutional Repository) ● Metadata: 117911 (Link to Publication Site) ● Publication site (DOI): 10.2199/jjsca.31.884 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204759730304 ● Search Scopus @ Elsevier (DOI): 10.2199/jjsca.31.884 (Tokushima University Institutional Repository: 117911, DOI: 10.2199/jjsca.31.884, CiNii: 1390001204759730304)
19.	Nami Kakuta, Yasuo M. Tsutsumi, Yousuke T. Horikawa, Hiroaki Kawano, Michiko Kinoshita, Katsuya Tanaka and Shuzo Oshita : Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures., The Journal of Medical Investigation : JMI, Vol.58, No.3-4, 246-251, 2011. (Summary) Post-operative nausea and vomiting (PONV) remains the most frequently reported patient complaint after anesthesia. Aprepitant is the first neurokinin-1(NK1) receptor antagonism available for use as an antiemetic. We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery. Sixty four patients receiving general anesthesia for laparoscopic gynecological surgery were randomly assigned to either receive a preoperative dose of 80 mg aprepitant or no drug. Efficacy was assessed in 2 and 24 hours after surgery. Primary and secondary endpoints were analyzed for the time intervals 0-2 hours (acute phase) and 2-24 hours (delayed phase). Vomiting, nausea, use of rescue anti-emetic, and visual analog scale (VAS) were assessed. Nausea was assessed on a 4-point scale, from 0 to 3. Sixty patients participated in the study. At acute phase, PONV was present in both control and NK1 group and were 63% and 43% respectively. The severity of nausea was much less in the NK1 group. PONV prevalence at delayed phase was present in control but absent in NK1 group 27% vs. 0%, respectively. The amount of pain medication used by patients in the NK1 group was significantly less for diclofenac and pentazocine suggesting increase pain tolerance. Neurokinin-1 receptor antagonism effectively lowered PONV increased pain tolerance, and expedited recovery in patients undergoing laparoscopic gynecological surgery. (Keyword) Adult / Antiemetics / Female / Gynecologic Surgical Procedures / Humans / Laparoscopy / Middle Aged / Morpholines / Pain Measurement / Pain Threshold / Postoperative Nausea and Vomiting / Receptors, Neurokinin-1 (Tokushima University Institutional Repository) ● Metadata: 83838 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.58.246 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21921426 ● Search Scopus @ Elsevier (PMID): 21921426 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.58.246 (Tokushima University Institutional Repository: 83838, DOI: 10.2152/jmi.58.246, PubMed: 21921426)
20.	Yasuo M. Tsutsumi, Rie Tsutsumi, Kazuaki Mawatari, Yutaka Nakaya, Michiko Kinoshita, Katsuya Tanaka and Shuzo Oshita : Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathway., Life Sciences, Vol.88, No.15-16, 725-729, 2011. (Summary) Compound K (C-K; 20-O-D-glucopyranosyl-20(S)-protopanaxadiol) is a novel ginsenoside metabolite formed by intestinal bacteria and does not occur naturally in ginseng. In this study, we investigated whether administration of C-K has protective effects on myocardial ischemia-reperfusion injury and its potential mechanisms. (Keyword) Androstadienes / Animals / calcium / Ginsenosides / Immunoblotting / male / Mice / Mice, Inbred C57BL / Mitochondria, Heart / Myocardial Infarction / Myocardial Reperfusion Injury / nitric oxide / Nitric Oxide Synthase Type III / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt (Link to Publication Site) ● Publication site (DOI): 10.1016/j.lfs.2011.02.011 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21338613 ● Summary page in Scopus @ Elsevier: 2-s2.0-79953283184 (DOI: 10.1016/j.lfs.2011.02.011, PubMed: 21338613, Elsevier: Scopus)
21.	Katsuya Tanaka, Takashi Kawano, Yasuo M. Tsutsumi, Michiko Kinoshita, Nami Kakuta, Kayo Hirose, Masakazu Kimura and Shuzo Oshita : Differential effects of propofol and isoflurane on glucose utilization and insulin secretion., Life Sciences, Vol.88, No.1-2, 96-103, 2011. (Summary) Volatile anesthetics, such as isoflurane, reverse glucose-induced inhibition of pancreatic adenosine triphosphate-sensitive potassium (K(ATP)) channel activity, resulting in reduced insulin secretion and impaired glucose tolerance. No previous studies have investigated the effects of intravenous anesthetics, such as propofol, on pancreatic K(ATP) channels. We investigated the cellular mechanisms underlying the effects of isoflurane and propofol on pancreatic K(ATP) channels and insulin secretion. (Keyword) adenosine triphosphate / Anesthetics, Inhalation / Anesthetics, Intravenous / Animals / Dose-Response Relationship, Drug / glucose / Glucose Tolerance Test / insulin / Islets of Langerhans / Isoflurane / KATP Channels / male / Membrane Potentials / Patch-Clamp Techniques / Propofol / Rabbits / Rats (Link to Publication Site) ● Publication site (DOI): 10.1016/j.lfs.2010.10.032 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21056586 ● Summary page in Scopus @ Elsevier: 2-s2.0-78650519087 (DOI: 10.1016/j.lfs.2010.10.032, PubMed: 21056586, Elsevier: Scopus)

Academic Letter:

1.	Michiko Kinoshita, Mizuki Komasaka and Katsuya Tanaka : ChatGPTs performance on JSA-certified anesthesiologist exam, Journal of Anesthesia, 2023. (Keyword) ChatGPT / GenerativeAI / large scale language model / Anesthesiology (Tokushima University Institutional Repository) ● Metadata: 118717 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00540-023-03275-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37902835 ● Search Scopus @ Elsevier (PMID): 37902835 ● Search Scopus @ Elsevier (DOI): 10.1007/s00540-023-03275-4 (Tokushima University Institutional Repository: 118717, DOI: 10.1007/s00540-023-03275-4, PubMed: 37902835)

Proceeding of International Conference:

1.	Yako Matsumoto, Michiko Kinoshita, Yoshinobu Tomiyama and Katsuya Tanaka : Protecting Intraoperative Patients In Time Of Natural DisastersPast Experiences And Lessons Learned: A Scoping Review, The Anesthesiology Annual Meeting 2023, San Francisco, Oct. 2023.
2.	Ryo Sekiguchi, Michiko Kinoshita, Ryosuke Kawanishi, Nami Kakuta, Yoko Sakai and Katsuya Tanaka : Comparison Between Hemodynamics Of Remimazolam And Propofol During General Anesthesia: A Randomized Study, The Anesthesiology Annual Meeting, Oct. 2022.
3.	Michiko Kinoshita, Yoko Sakai, Kimiko Katome, Tomomi Matsumoto, Yuka Jinnouchi, Noriko Niki, Shizuka Sakurai, Yoshiko Yoshida and Katsuya Tanaka : The transition in the eye gaze is a helpful predictor of emergence from general anesthesia with sevoflurane combined with remifentanil in children, but not adults, --- A prospective observational study ---, The Annual Meeting of the American Society of Anesthesiologists, WEB, Oct. 2020.
4.	Mai Morimoto, Katsuya Tanaka, Michiko Kinoshita, Noriko Kambe, Ryosuke Kawanishi, Katsuyoshi Kume, Naohiro Oshita, Yasuo M. Tsutsumi and Shuzo Oshita : Effects of new developed mask for novel mask holding on the quality of mask ventilation and the pressure between face and mask., The American Society of Anesthesiologist Annual Meeting, San Francisco, Oct. 2013.
5.	Michiko Kinoshita, Katsuya Tanaka, Yasuo Tsutsumi and Shuzo Oshita : Role of calcium-activated potassium channel and cAMP-dependent protein kinase on isflurane-induced postconditoning., American Society of Anesthesiologists 2011 Annual Meeting, Chicago, Oct. 2011.
6.	Katsuya Tanaka, Michiko Kinoshita, Yasuo Tsutsumi, Kaori Takata and Shuzo Oshita : Simvastatin restores anesthetic postconditioning in the presence of hyperglycemia in vivo rabbits., American Society of Anesthesiologists 2011 Annual Meeting, Chicago, Oct. 2011.
7.	Michiko Kinoshita, Katsuya Tanaka, Yasuo Tsutsumi, Hirose Kayo and Shuzo Oshita : The effect of the novel mask ventilation technique on airway management., The Annual Meeting of the American Society of Anesthesiologists, San Diego, California, Oct. 2010.
8.	Michiko Kinoshita, Katsuya Tanaka, Jinnouchi Yuka, Yasuo Tsutsumi and Shuzo Oshita : Dose dependent effects of remifentanil on perioperative immune-inflammtory response in patients., The Annual Meeting of the American Society of Anesthesiologists, San Diego, California, Oct. 2010.
9.	Hirose Kayo, Shuzo Oshita, Michiko Kinoshita, Katsuya Tanaka and Yasuo Tsutsumi : The role of O-linked -N-acetylglucosamine in the cardiac protection induced by isoflurane., The Annual Meeting of the American Society of Anesthesiologists, San Diego, California, Oct. 2010.

Proceeding of Domestic Conference:

1.	松本弥子 (名), Yoko Sakai, Michiko Kinoshita and Katsuya Tanaka : Impact of Anesthesiologists' Experience on Anesthetic Management in Cesarean Section, 第11回日本区域麻酔学会学術集会, Apr. 2024.
2.	SEKIGUCHI Ryo, 鈴木奈央, Michiko Kinoshita and Katsuya Tanaka : 携帯型ディスポーザブル注入ポンプの投与精度に関する検討 —機械式ポンプとバルーン式ポンプの比較—, 第41回日本麻酔 · 集中治療テクノロジー学会, Nov. 2023.
3.	手塚信裕, Yoko Sakai, Michiko Kinoshita, 池添照代, 藤本理恵子 and Katsuya Tanaka : Consideration of additional contacts to doctors during general anesthesia by nurses who have completed specic practice training., 日本麻酔科学会中国・四国支部第60回学術集会, Sep. 2023.
4.	Komasaka Mizuki, Michiko Kinoshita and Katsuya Tanaka : Performance of ChatGPT on the Japanese Society of Anesthesiologists Certified Anesthesiologist Examination, 日本麻酔科学会中国・四国支部第60回学術集会, Sep. 2023.
5.	Suzuki Nao, Michiko Kinoshita and Katsuya Tanaka : Trends and Factors in the Number of Abstracts at the Annual Meeting of the Japanese Society of Anesthesiologists, 日本麻酔科学会中国・四国支部第60回学術集会, Sep. 2023.
6.	Yuki Ishikawa, Michiko Kinoshita and Katsuya Tanaka : The Impact of Positive End-Expiratory Pressure on Sevoflurane Wash-out Time in Anesthesia Breathing Circuits: Simulation-based Study Using Test Lung, 日本麻酔科学会中国・四国支部第60回学術集会, Sep. 2023.
7.	Michiko Kinoshita, Katsuya Tanaka and Yoko Sakai : Bibliometric Analysis using Revealed Comparative Advantage in Publication Output in Anesthesiology and Pain Medicine, The 70th Annual Meeting of the Japanese Society of Anesthesiologists, Jun. 2023.
8.	Michiko Kinoshita, Mina Takahashi, Katsuya Tanaka and Yoko Sakai : Authorship by Gender in Anesthesiology Journals: A Retrospective Cross-sectional Study for Japan, The 70th Annual Meeting of the Japanese Society of Anesthesiologists, Jun. 2023.
9.	SEKIGUCHI Ryo, Michiko Kinoshita and Katsuya Tanaka : A Study of the Accuracy of Dosing Rates for Portable Disposable Infusion Pumps, The 70th Annual Meeting of the Japanese Society of Anesthesiologists, Jun. 2023.
10.	Yuta Uemura, 常城あゆみ, Michiko Kinoshita, Ryo Sekiguchi and Katsuya Tanaka : 高齢者におけるエフェドリンの昇圧効果および循環動態変化の検討:前向き観察研究, 日本麻酔科学会第69回学術集会, Jun. 2022.
11.	前田卓也, Kohji Shinohara, 武藤さら良, Michiko Kinoshita, Ryosuke Kawanishi and Katsuya Tanaka : 神経核内封入体病患者の麻酔経験, 日本麻酔科学会中国・四国支部第59回学術集会, 2022.
12.	Rikako Takahashi, 武藤さら良, 松田みゆき, Michiko Kinoshita, Nami Kakuta and Katsuya Tanaka : 修正型電気けいれん療法(mECT)誘発性たこつぼ型心筋症の再発予防のための麻酔管理:症例報告と文献レビュー, 日本麻酔科学会中国・四国支部第59回学術集会, 2022.
13.	武藤さら良, 富也河原, Michiko Kinoshita, Yoko Sakai and Katsuya Tanaka : 修正型電気痙攣療法におけるケタミン麻酔の有用性と問題点, 日本麻酔科学会第68回学術集会, 2021.
14.	SEKIGUCHI Ryo, 富也河原, Michiko Kinoshita, Yuki Ishikawa, Yoko Sakai and Katsuya Tanaka : サージカルマスクがオープンタイプの酸素マスクを用いた酸素療法に与える影響:ランダム化，クロスオーバー，単盲検試験, 日本麻酔科学会第68回学術集会, 2021.
15.	松田みゆき, Michiko Kinoshita, SEKIGUCHI Ryo, Yuki Ishikawa, Yohko Sakai and Katsuya Tanaka : 酸素マスクの種類と呼吸パターンがサージカルマスク併用の酸素療法に与える影響:シミュレーターを用いた研究, 日本麻酔科学会中国・四国支部第58回学術集会, 2021.
16.	岩佐みゆき, Kyoko Nishi, 佐藤功志, 浅井孝仁, Takuya Maeda, 中村昌史, Muneyuki Kadota, Kumiko Tanaka, Naoya Kawakita, 武田美佐, 藤永裕之, 近藤明男, Michiko Kinoshita, Yoko Sakai, Katsuya Tanaka, Masahiro Abe, Masaji Nishimura and Shoji Kagami : メディカルゾーン(MZ)重点研修プログラムにおける麻酔化融合研修, 第261回徳島医学会学術集会, Aug. 2020.
17.	吉田佳子, Michiko Kinoshita, 松本朋美, 香留希実子, Yoko Sakai and Katsuya Tanaka : 吸入麻酔薬とレミフェンタニルを用いた小児全身麻酔からの覚醒と眼位の変化の関係, 日本麻酔科学会第67回学術集会, Jun. 2020.
18.	曾我部洋平, Michiko Kinoshita, 陣内由佳, Naoji Mita and Katsuya Tanaka : 抗Jra抗体を有する血友病B保因者の乳房部分切除術の麻酔経験, 日本麻酔科学会中国・四国第54回学術集会, Sep. 2017.
19.	Yasuo Tsutsumi, Katsuya Tanaka, Tomohiro Soga, Noriko Kambe, Michiko Kinoshita and Shuzo Oshita : 敗血症マウスにおける分岐鎖アミノ酸投与がタンパク合成に及ぼす影響, 第59回日本麻酔科学会, Jun. 2012.
20.	門田尚子, Yasuo Tsutsumi, Shuzo Oshita, 河野裕明, 笠井飛鳥, Michiko Kinoshita, Nami Kakuta and Katsuya Tanaka : 術後嘔気・嘔吐に対する選択的ニューロキニン1受容体拮抗薬の有効性, 日本臨床麻酔学会第31回大会, Nov. 2011.
21.	Nami Kakuta, Yasuo Tsutsumi, Michiko Kinoshita, Katsuya Tanaka, 河野裕明, Shuzo Oshita and Shuzo Oshita : 選択的ニューロキニン1受容体拮抗型制吐剤が術後嘔気嘔吐に及ぼす影響, 日本麻酔科学会第58回学術集会, May 2011.
22.	金村朋美, Katsuya Tanaka, Michiko Kinoshita, 門田尚子, Yasuo Tsutsumi, Shuzo Oshita and Shuzo Oshita : Grip and Lift法とEC法の2種類のマスク換気中にマスクと顔面の間にかかる圧分布の検討, 日本麻酔科学会第58回学術集会, May 2011.
23.	Michiko Kinoshita, Katsuya Tanaka, Yasuo Tsutsumi, 福田浩平, 真鍋佐和 and Naohiro Oshita : ソフルランのポストコンディショニング効果におけるCa2+依存性K+チャネルとcAMP依存性プロテインキナーゼの役割, 日本麻酔科学会第58回学術集会, May 2011.
24.	廣瀬佳代, Katsuya Tanaka, Michiko Kinoshita, Yasuo Tsutsumi and Naohiro Oshita : イソフルランによる心筋保護効果におけるO-Linked β-N-Acetylglucosamineとミトコンドリア機能, 日本麻酔科学会第58回学術集会, May 2011.
25.	Michiko Kinoshita, Katsuya Tanaka, 野村佳世, 濱口英佑 and Shuzo Oshita : 新しいマスク換気法とマスクの開発∼より安全な麻酔導入に向けて∼, 日本麻酔科学会第57回学術集会, Jun. 2010.
26.	Yasuo Tsutsumi, 廣瀬佳代, Michiko Kinoshita, Nami Kakuta, Katsuya Tanaka and Shuzo Oshita : 吸入麻酔薬による遅延型プレコンディショニングの細胞膜ドメインに及ぼす影響, 第57回日本麻酔科学会, Jun. 2010.
27.	Michiko Kinoshita, Katsuya Tanaka, 河野崇, 陣内由佳 and Shuzo Oshita : 高用量レミフェンタニルによる全身麻酔がストレス反応に及ぼす影響, 日本麻酔科学会第57回学術集会, Jun. 2010.
28.	Katsuya Tanaka, 河野崇, Yasuo Tsutsumi, Michiko Kinoshita, 廣瀬佳代 and Shuzo Oshita : 麻酔薬が膵臓β細胞のATP感受性K+チャネルに及ぼす影響, 第57回日本麻酔科学会, Jun. 2010.
29.	Nami Kakuta, Katsuya Tanaka, Michiko Kinoshita, 河野崇, Yasuo Tsutsumi and Shuzo Oshita : プロポフォールとイソフルランがブドウ糖負荷試験に及ぼす影響, 第57回日本麻酔科学会, Jun. 2010.

Patent:

1.	Katsuya Tanaka, Michiko Kinoshita and Shuzo Oshita : GL用麻酔用マスク, (Aug. 2010), (Mar. 2012), 2010-191931.

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吸入麻酔薬と近赤外線の併用は高齢モデルにおいて心保護効果を増強するか？ (Project/Area Number: 20K17814 )
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Assistant Professor : Kinoshita, Michiko

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