Tokushima University / Educator and Researcher Directory --- Aota, Keiko

Personal Web Page

https://researchmap.jp/70437391 (researchmap)

Field of Study

○	Oral and Maxillofacial Surgery
○	口腔外科学
○	Oral and Maxillofacial Surgery
○	Oral and Maxillofacial Surgery

Subject of Study

○	抗TNF療法による唾液腺機能再生医療の構築
○	IP-10を分子標的としたシェーグレン症候群の新規診断・治療法の開発
○	JAK/STATシグナル制御を標的としたシェーグレン症候群の新規治療戦略
○	免疫細胞フェノタイプによるシェーグレン症候群の個別化医療の構築 (Sjögren's syndrome, 免疫細胞)

Book / Paper

Book:

1.	Keiko Aota : 粘液嚢胞, Jun. 2023.
2.	Keiko Aota : 薬の副作用による著しい歯肉肥大のある方の口腔ケア, Aug. 2022.
3.	千葉俊美, 山田浩之, Masayuki Azuma and Keiko Aota : 歯科医師のための内科学, Mar. 2021.
4.	Keiko Aota and Masayuki Azuma : 口腔外科学第4版, Ishiyaku Publishers,Inc., Tokyo, Feb. 2020.
5.	Keiko Aota and Masayuki Azuma : 悪性腫瘍治療時の口腔ケア, 医歯薬出版株式会社, May 2014.
6.	Katsuhiko Yoshimoto, Masashi Akaike, Minoru Irahara and Keiko Aota : 歯科医師のための医学ハンドブック, 医歯薬出版株式会社, Tokyo, May 2014.

Academic Paper (Judged Full Paper):

1.	Hiromichi Yumoto, 舞田健夫 (名), Yutaka Kawano, 植原治 (名), 安彦善裕 (名), Keiko Aota, Tetsuji Takayama and 四柳宏 (名) : 歯科領域におけるウイルス性肝炎に関する動画に対するアンケート調査., The Japanese Journal of Conservative Dentistry, Vol.67, No.5, 276-287, 2024.
2.	Keiko Aota, Kohichi Kani, Shinji Ono, Kohei Naniwa, Yukihiro Momota, Makoto Fukui, Naozumi Ishimaru and Masayuki Azuma : Activation of Janus kinase 2 contributes to the autoimmune pathology in the salivary glands of patients with Sjögren's syndrome, Oral Science International, 2024. (Tokushima University Institutional Repository) ● Metadata: 119316 (Link to Publication Site) ● Publication site (DOI): 10.1002/osi2.1241 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1002/osi2.1241 (Tokushima University Institutional Repository: 119316, DOI: 10.1002/osi2.1241)
3.	S Supriya, R Ushikoshi-Nakayama, T Yamazaki, D Omagari, Keiko Aota, H Inoue, N Matsumoto and I Saito : Effects of polyphenols in non-centrifugal cane sugar on saliva secretion: in vitro and in vivo experiments and a randomized controlled trial, Journal of Clinical Biochemistry and Nutrition, Vol.2, No.72, 171-182, 2023. (Summary) This study examined the bioactivities and mechanisms of the non-centrifugal cane sugar polyphenols saponarin, schaftoside, and isoschaftoside in the salivary gland and their effects on salivation. In acute isolated C57BL/6N mouse submandibular gland cells, these polyphenols led to a higher increase in intracellular calcium after stimulation with the muscarinic agonist carbachol. Stimulation of these cells with polyphenols enhanced ATP production, aquaporin-5 translocation to the plasma membrane and eliminated intracellular reactive oxygen species generated by HO. In addition, phosphorylation of endothelial nitric oxide synthase and increased nitric oxide production in vascular endothelial cells were observed. administration of these polyphenols to C57BL/6N male mice resulted in significantly increased blood flow (saponarin, = 0.040; isoschaftoside, = 0.010) and salivation (saponarin, = 0.031). A randomized controlled trial showed that intake of non-centrifugal cane sugar significantly increased saliva secretion compared with placebo ( = 0.003). These data suggest that non-centrifugal cane sugar polyphenols affect several pathways that support salivation and increase saliva secretion by enhancing vasodilation. Hence, non-centrifugal cane sugar polyphenols can be expected to maintain saliva secretion and improve reduced saliva flow. (Tokushima University Institutional Repository) ● Metadata: 119339 (Link to Publication Site) ● Publication site (DOI): 10.3164/jcbn.22-114 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36936876 ● Search Scopus @ Elsevier (PMID): 36936876 ● Search Scopus @ Elsevier (DOI): 10.3164/jcbn.22-114 (Tokushima University Institutional Repository: 119339, DOI: 10.3164/jcbn.22-114, PubMed: 36936876)
4.	Fumiya Kano, Noboru Hashimoto, Yao Liu, Linze Xia, Takaaki Nishihara, Wakana Oki, Keita Kawarabayashi, Noriko Mizusawa, Keiko Aota, Takayoshi Sakai, Masayuki Azuma, Hideharu Hibi, Tomonori Iwasaki, Tsutomu Iwamoto, Nobuyasu Horimai and Akihito Yamamoto : Therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for radiation-induced mouse xerostomia, Scientific Reports, Vol.13, No.1, 2706-2719, 2023. (Summary) Radiation therapy for head and neck cancers is frequently associated with adverse effects on the surrounding normal tissue. Irreversible damage to radiation-sensitive acinar cells in the salivary gland (SG) causes severe radiation-induced xerostomia (RIX). Currently, there are no effective drugs for treating RIX. We investigated the efficacy of treatment with conditioned medium derived from stem cells from human exfoliated deciduous teeth (SHED-CM) in a mouse RIX model. Intravenous administration of SHED-CM, but not fibroblast-CM (Fibro-CM), prevented radiation-induced cutaneous ulcer formation (p < 0.0001) and maintained SG function (p < 0.0001). SHED-CM treatment enhanced the expression of multiple antioxidant genes in mouse RIX and human acinar cells and strongly suppressed radiation-induced oxidative stress. The therapeutic effects of SHED-CM were abolished by the superoxide dismutase inhibitor diethyldithiocarbamate (p < 0.0001). Notably, quantitative liquid chromatography-tandem mass spectrometry shotgun proteomics of SHED-CM and Fibro-CM identified eight proteins activating the endogenous antioxidant system, which were more abundant in SHED-CM than in Fibro-CM (p < 0.0001). Neutralizing antibodies against those activators reduced antioxidant activity of SHED-CM (anti-PDGF-D; p = 0.0001, anti-HGF; p = 0.003). Our results suggest that SHED-CM may provide substantial therapeutic benefits for RIX primarily through the activation of multiple antioxidant enzyme genes in the target tissue. (Keyword) Mice / Humans / Animals / Antioxidants / Stem Cells / Disease Models, Animal / Xerostomia / Tooth, Deciduous (Tokushima University Institutional Repository) ● Metadata: 118051 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-023-29176-w (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36792628 ● Summary page in Scopus @ Elsevier: 2-s2.0-85148115146 (Tokushima University Institutional Repository: 118051, DOI: 10.1038/s41598-023-29176-w, PubMed: 36792628, Elsevier: Scopus)
5.	高原由実子, Hirokazu Miki, Shingen Nakamura, 林成樹, Ryohei Sumitani, Masahiro Oura, Kimiko Sogabe, 髙橋真美子, 丸橋朋子, 富永誠記, 岡本秀樹, Naoto Okada, 矢野由美子, 高橋真理, 大坂朱美, Takeshi Harada, Shiroh Fujii, Toshiyuki Suge, Keiko Aota, Shuji Ozaki and Masahiro Abe : 徳島県におけるHIV感染症および後天性免疫不全症候群患者の臨床的特徴と今後の課題, Shikoku Acta Medica, Vol.78, No.5-6, 193-198, 2022. (Summary) 【Introduction】The survival rate in patients with HIV infection and acquired immunodeficiency syndrome (AIDS) has been improved dramatically due to the advances in anti-HIV drug therapy, while aging-associated complications become a critical issue. The incidence of sudden occurrence of AIDS without prior detection of HIV infection, so called ``Ikinari AIDS'', still remains high. 【Objective】We retrospectively analyzed the incidence and clinical characteristics of HIV/AIDS patients in both Tokushima University Hospital and Tokushima Prefectural Central Hospital. 【Results】Eighty four patients (74 males and 10 females) with a median age of 39 years old (range 16 - 85) were enrolled. Thirty-four patients (40.5%) were diagnosed with ``Ikinari AIDS'' from 2001 to 2020. All 4 patients were diagnosed with ``Ikinari AIDS'' after 2020. AIDS-defining illnesses were diagnosed as follows ; pneumocystis pneumonia in 21 cases, CMV infection in 8 cases and candidiasis in 6 cases. All patients over 60 years old were suffered from AIDS. Other complications included syphilis in 17 cases, hepatitis B infection in 12 and herpes zoster in 7. 【Discussion/Conclusion】In Tokushima, the incidence rate of ``Ikinari AIDS'' appeared to be higher than that of national average. COVID - 19 pandemic hampered the public health care services of awareness-raising activity for HIV infection and telephone consultations about HIV, which may become more lease asymptomatic HIV patients without diagnosis. For early diagnosis of HIV/AIDS, it is becoming more important to share information to make early screening of HIV infection among medical staffs, such as medical doctors, dentists, nurses, pharmacists and MSWs. (Keyword) HIV / AIDS / Ikinari AIDS (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520013962706680448 (CiNii: 1520013962706680448)
6.	Keiko Aota and Kohichi Kani : シェーグレン症候群新規治療薬としてのJAK阻害薬の可能性, The Japanese Journal of Tissue Culture Society for Dental Research, Vol.31, No.2, 1-8, 2022. (Summary) Sjögren's syndrome (SS) is a chronic autoimmune disease involving the salivary and lacrimal glands. Expression of interferon (IFN)-related molecules and C-X-C motif chemokine ligand 10 (CXCL10) is upregulated in labial salivary glands (LSGs) of patients with primary SS (pSS). CXCL10 plays a role in SS pathogenesis via immune-cell accumulation. In various inflammatory diseases, including pSS, the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is activated; moreover, in pSS, the JAK/STAT pathway is associated with CXCL10 production in the LSG tissues. Here, we evaluated potential JAK inhibitor, Baricitinib, as therapeutic agents for pSS by analyzing LSGs of patients with pSS and immortalized normal human salivary gland cell lines, namely NS-SV-DC, and NS-SV-AC. Immunohistochemical analysis revealed strong expression of phosphorylated JAK1 and JAK2 in the ductal epithelial cells of LSGs of patients with pSS. Additionally, phosphorylated JAK2 was observed in several immune cells infiltrating around the ductal epithelium. Baricitinib, a selective JAK1/2 inhibitor, significantly inhibited IFN-γ-induced CXCL10 expression as well as CXCL10 protein levels in an immortalized normal human salivary gland ductal cell (NS-SV-DC) line. Additionally, western blotting showed that baricitinib suppressed the IFN-γ-induced phosphorylation of STAT1 and STAT3. In this review, based on these aforementioned fi ndings, we discussed the potential of JAK inhibitors as new therapeutic agents for pSS. JAK inhibitors may be useful in the treatment of patients with pSS. (Keyword) Sjögren's syndrome / JAK (Tokushima University Institutional Repository) ● Metadata: 119058 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1010861618202610688 (Tokushima University Institutional Repository: 119058, CiNii: 1010861618202610688)
7.	K Takamatsu, J Tanaka, R Katada, K Azuma, I Takakura, Keiko Aota, T Kamatani, T Shirota, S Inoue and K Mishima : Aging-associated stem/progenitor cell dysfunction in the salivary glands of mice, Experimental Cell Research, Vol.409, No.1, 112889, 2022. (Summary) Although stem cell aging leads to a decline in tissue homeostasis and regenerative capacity, it remains unclear whether salivary gland stem cell function changes during this process. However, the salivary glands are gradually replaced by connective tissue during aging. Here, we show a decline in the stem cell ability of CD133-positive stem/progenitor cells in the salivary glands of aged mice. The CD133-positive cells were isolated from young, adult, and aged mice. The number of CD133-positive cells was significantly decreased in aged mice. They also showed a lower sphere formation capacity compared to young and adult mice. RNA sequencing revealed that CD133-positive cells in aged mice exhibited lower gene expression of several aging-related genes, including FoxO3a, than those in young and adult mice. Salivary gland cells infected with a recombinant lentivirus encoding the FoxO3a gene showed a reduction in oxidative stress induced by hydrogen peroxide compared with those infected with a control virus. Thus, FoxO3a may inhibit stem cell aging via oxidative stress. (Keyword) Aging / Animals / Cell Line / Cellular Senescence / Female / HEK293 Cells / Humans / Mice / Mice, Inbred C57BL / Regeneration / Salivary Glands / Stem Cell Transplantation / Stem Cells (Link to Publication Site) ● Publication site (DOI): 10.1016/j.yexcr.2021.112889 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34678306 ● Summary page in Scopus @ Elsevier: 2-s2.0-85117759787 (DOI: 10.1016/j.yexcr.2021.112889, PubMed: 34678306, Elsevier: Scopus)
8.	西條早希, Shingen Nakamura, Hirokazu Miki, 谷口早紀, 岡本秀樹, 富永誠記, Naoto Okada, 矢野由美子, 髙橋真理, Keiko Aota, Toshiyuki Suge, Hiroyoshi Watanabe, 大坂朱美 and Masahiro Abe : 徳島大学病院における先天性血友病患者(成人例)の実態調査∼移行期医療の重要性∼, Shikoku Acta Medica, Vol.77, No.5-6, 261-268, 2021. (Summary) 【Introduction】Congenital hemophilia is a category of hemorrhagic disease caused by a genetic defect in the production of coagulation factors. It is treated by administering regular coagulation factor injections on an ongoing basis. Hemophilia is a hereditary illness, often causing social and psychological problems as a result of the disease. To analyze the objective effects of hemophilia, we conducted a retrospective analysis in Tokushima University Hospital. 【Result】All 23 cases were men between the ages of20and72. Hemophilia A was present in17cases, and hemophilia B was present in six. Nineteen out of 23 cases were severe, and the others were intermediate. Medical assessments were conducted at pediatrics in seven cases and hematology in 16 cases. Adoption of the self-injection technique was not realized in five cases. Seventeen cases were complicated by hemophilic arthropathy, seven with human immunodeficiency virus(HIV), and 12 with hepatitis C virus. Eight participants were unemployed, and17were unmarried. 【Discussion】 Many adult hemophilia patients still visit pediatrics in our hospital. Hemophilia in the period of growth between adolescence and young adulthood is often accompanied by life-altering events such as entering higher education, marriage, and work experience. Therefore, collaboration among professionals of multiple occupations, such as doctors, nurses, pharmacists, medical social workers, and clinical psychologists, is essential. Furthermore, there are many cases of HIV and hepatitis C virus infections complicating hemophilia study due to the stigma surrounding HIV-tainted blood. 【Conclusion】It is imperative that we establish a long-term, sustainable, and multi-disciplinary transitional care and medical support system for patients and their families. (Keyword) Congenital Hemophilia / Transitional Care (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520855132284626560 (CiNii: 1520855132284626560)
9.	Shin-Ichi Yamada, Kazuyuki Koike, Tanaka Emiko Isomura, Daichi Chikazu, Kenji Yamagata, Masahiro Iikubo, Satoshi Hino, Hideharu Hibi, Kouji Katsura, Seiji Nakamura, Takeshi Nomura, Yoshiyuki Mori, Itaru Tojyo, Narisato Kanamura, Iku Yamamori, Keiko Aota, Shigeyuki Fujita, Hideki Tanzawa and Hiroshi Kurita : The effects of perioperative oral management on perioperative serum albumin levels in patients treated surgically under general anesthesia: A multicenter retrospective analysis in Japan., Medicine, Vol.100, No.10, 2021. (Summary) The purpose of the present study was to investigate the efficacy of perioperative oral managements (POMs) on perioperative nutritional conditions in patients undergoing surgery with general anesthesia. Medical records were retrospectively reviewed and the effects of POMs were investigated based on a large number of cases using a multicenter analysis. The profile of serum albumin levels was assessed and compared between patients with and without POMs using the multivariate analysis. Seventeen Eleven thousand and one hundred sixty patients (4,873 males and 6,287 females) were reviewed. Of these, 2710 patients (24.3%) had undergone POMs. The results of a multivariate analysis revealed the significant positive effect of POMs on perioperative serum albumin level (change between at admission and discharge, (Estimate: 0.022, standard error: 0.012, P < .0001). Patient gender, age, surgical site, performance status, the American Society of Anesthesiologists (ASA) physical status classification, operation time, amount of blood loss, and serum albumin level at admission were also significant predictors. Adjusted multivariate analysis of the effects of POMs on perioperative change of serum albumin level in all subjects reveled the significance of POMs intervention (estimate: 0.022, standard error: 0.012, P < .0001). These results suggest that POMs exerts significant positive effects on perioperative serum albumin levels in patients underwent surgery under general anesthesia. (Keyword) Adult / Anesthesia, General / Female / Humans / Japan / Male / Middle Aged / Oral Hygiene / Perioperative Care / Perioperative Period / Postoperative Complications / Retrospective Studies / Risk Factors / Serum Albumin, Human / Surgical Procedures, Operative / Treatment Outcome (Tokushima University Institutional Repository) ● Metadata: 116172 (Link to Publication Site) ● Publication site (DOI): 10.1097/MD.0000000000025119 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33725909 ● Search Scopus @ Elsevier (PMID): 33725909 ● Search Scopus @ Elsevier (DOI): 10.1097/MD.0000000000025119 (Tokushima University Institutional Repository: 116172, DOI: 10.1097/MD.0000000000025119, PubMed: 33725909)
10.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, Shinji Ono, Yukihiro Momota and Masayuki Azuma : Inhibition of JAK-STAT Signaling by Baricitinib Reduces Interferon-γ-Induced CXCL10 Production in Human Salivary Gland Ductal Cells., Inflammation, Vol.44, No.1, 206-216, 2021. (Tokushima University Institutional Repository) ● Metadata: 116171 (Link to Publication Site) ● Publication site (DOI): 10.1007/s10753-020-01322-w (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32772240 ● Search Scopus @ Elsevier (PMID): 32772240 ● Search Scopus @ Elsevier (DOI): 10.1007/s10753-020-01322-w (Tokushima University Institutional Repository: 116171, DOI: 10.1007/s10753-020-01322-w, PubMed: 32772240)
11.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani and Masayuki Azuma : シェーグレン症候群の病態形成におけるCXCL10の役割, The Japanese Journal of Tissue Culture Society for Dental Research, Vol.29, No.2, 39-47, 2020. (Summary) Sjögren's syndrome (SS) is a common autoimmune disease characterized by the destruction of acinar structure by marked lymphocytic infiltrates in the salivary and lacrimal glands, resulting in sicca symptoms. Gene expression profiling of lip salivary glands (LSGs) shows that C-X-C motif chemokine 10 (CXCL10) expression is upregulated in patients with primary SS (pSS). CXCL10 and its receptor, C-X-C receptor 3 (CXCR3), contribute to the pathogenesis of SS. We investigated the clinical significance of CXCL10 and CXCR3 in the autoimmune lesions of pSS and the molecular mechanisms of CXCL10 upregulation in the salivary gland cells. CXCL10 showed particularly intense staining in LSG ductal cells from pSS patients. CXCR3 expression was detected primarily in CD163+ macrophages. The number of CXCR3+CD163+ macrophages was inversely correlated with the severity of LSG inflammatory lesions. Our in vitro experiments demonstrated that human salivary gland ductal (NS-SV-DC) cells produced higher levels of CXCL10 than acinar (NS-SV-AC) cells. Furthermore, NS-SV-DC and NS-SV-AC cells had different regulators of CXCL10 enhancement: interferon (IFN)-γ had more potential than IFN-α, tumor necrosis factor (TNF)-α, and interleukin (IL)1-β in the induction of CXCL10 production in NS-SV-DC cells, whereas TNF-α had the potential to induce CXCL10 production in NS-SV-AC cells. Our results suggest that CXCL10 overexpression in salivary glands is mainly caused by IFN-γ-stimulated salivary gland ductal cells. The enhanced production of CXCL10 by ductal cell IFN-γ results in the migration of CXCR3+ immune cells. CXCL10 plays an important role in SS pathogenesis, and CXCL10 regulation may be useful in the treatment of SS patients. (Keyword) Sjögren's syndrome / C-X-C motif chemokine 10 / CXCL10 / interferon-gamma / IFN-γ (Tokushima University Institutional Repository) ● Metadata: 116159 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573950402387033216 (Tokushima University Institutional Repository: 116159, CiNii: 1573950402387033216)
12.	Yuriko Goto, Miho Ibi, Hirotaka Sato, Junichi Tanaka, Rika Yasuhara, Keiko Aota, Masayuki Azuma, Toshiyuki Fukada, Kenji Mishima and Tarou Irie : PLAG1 enhances the stemness profiles of acinar cells in normal human salivary glands in a cell type-specific manner., Journal of Oral Biosciences, Vol.62, No.1, 99-106, 2020. (Summary) Details of the histogenesis of salivary gland tumors are largely unknown. The oncogenic role of PLAG1 in the salivary gland has been demonstrated in vivo. Herein, we demonstrate PLAG1 roles in the acinar and ductal cells of normal human salivary glands to clarify the early events that occur during the histogenesis of salivary gland tumors. Normal salivary gland cells with acinar and ductal phenotypes were transfected with PLAG1 plasmid DNA. Subsequently, PLAG1 overexpressed and mock cells were examined by cell proliferation, transwell migration, and salisphere formation assays. Differentiation and salivary and pluripotent stem cell marker expression levels were evaluated by quantitative reverse transcription-polymerase chain reaction and immunofluorescence. Alterations in transcriptional expressions were investigated via cap analysis of gene expression with gene-enrichment and functional annotation analysis. PLAG1 promoted cell proliferation and transwell migration in the acinar and ductal cells, and markedly enhanced the stemness profiles and luminal cell-like profiles in acinar cells; the stemness profiles were partially increased in the ductal cells. PLAG1 enhanced the stemness profiles in the acinar cells of normal human salivary glands in a cell type-specific manner. Thus, it may be involved in salivary gland tumorigenesis by increasing the stemness character of the normal salivary gland cells. (Tokushima University Institutional Repository) ● Metadata: 115184 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.job.2020.01.002 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32007659 ● Summary page in Scopus @ Elsevier: 2-s2.0-85079425125 (Tokushima University Institutional Repository: 115184, DOI: 10.1016/j.job.2020.01.002, PubMed: 32007659, Elsevier: Scopus)
13.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, 高瀬奈緒, Yuki Miyamoto, Shinji Ono and Masayuki Azuma : Primary Glossodynia Well-Treated with Triple-Drug Combination: A Case Series, Japanese Journal of Orofacial Pain, Vol.11, No.1, 21-27, 2019. (Summary) Primary glossodynia is characterized by abnormal sensations such as tongue pain without pathological changes and is not fully understood. Primary glossodynia is reported to be associated with neurophathic pain. We describe the cases of 3 patients(2 males, 1 female, mean age 54.3 years, range 42-79 years) with primary glossodynia that was treated with the concomitant medication of pregabalin (50-300mg/day), tramadol hydrochloride/acetaminophen tablets (37.5/325-150/1,300mg/day), and powdered processed aconite roots (0.5-1.5mg/day). This medication remarkably relieved the patients primary glossodynia and promoted health-reated quality of life of them. Significant adverse events did not occur in any of the cases.<br>This concomitant medication may be useful for the treatment of primary glossodynia. (Keyword) primary glossodynia / pregabalin / tramadol hydrochloride / acetaminophen / powdered processed aconite roots (Link to Publication Site) ● Publication site (DOI): 10.11264/jjop.11.21 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390846609775857792 ● Search Scopus @ Elsevier (DOI): 10.11264/jjop.11.21 (DOI: 10.11264/jjop.11.21, CiNii: 1390846609775857792)
14.	Keiko Aota, Shinji Ono, Tomoko Yamanoi, Kohichi Kani, Yukihiro Momota and Masayuki Azuma : MMP-9 inhibition suppresses interferon-γ-induced CXCL10 production in human salivary gland ductal cells., Inflammation, Vol.42, No.6, 2148-2158, 2019. (Summary) Gene expression profiling of lip salivary gland (LSG) has shown that C-X-C motif chemokine 10 (CXCL10) and matrix metalloproteinase 9 (MMP9) expression is upregulated in primary Sjögren's syndrome (pSS) patients. Although CXCL10 and MMP-9 are both associated with pSS pathogenesis, the potential relationship between these two factors has not been investigated. In this study, we used LSG sections from pSS patients and human salivary gland cell lines to investigate the relationship between CXCL10 and MMP-9. Immunofluorescence analyses revealed that CXCL10 and MMP-9 were co-expressed in the LSG of pSS patients, particularly in expanded ductal cells. Furthermore, RT-qPCR analyses on human salivary gland ductal NS-SV-DC cells confirmed that CXCL10 expression was induced by interferon (IFN)-γ, whereas that of MMP9 was stimulated by IFN-α, tumor necrosis factor-α, and interleukin-1β. Remarkably, MMP-9 inhibition in IFN-γ-stimulated NS-SV-DC cells significantly decreased CXCL10 mRNA and secreted protein levels. Further analyses established that MMP-9 inhibition in IFN-γ-stimulated NS-SV-DC cells decreased STAT1 phosphorylation and hence suppressed IFN-γ signaling. Collectively, these results suggest that in addition to its reported role in the destruction of acinar structures, MMP-9 is involved in the IFN-γ-induced production of CXCL10 in pSS lesions. We believe that our findings open the door to the development of novel treatments for pSS, based on the modulation of MMP-9 activity. (Keyword) Cell Line / Cells, Cultured / Chemokine CXCL10 / Humans / Interferon-gamma / Matrix Metalloproteinase 9 / Phosphorylation / STAT1 Transcription Factor / Salivary Ducts / Salivary Glands / Sjogren's Syndrome (Tokushima University Institutional Repository) ● Metadata: 115182 (Link to Publication Site) ● Publication site (DOI): 10.1007/s10753-019-01079-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31440939 ● Summary page in Scopus @ Elsevier: 2-s2.0-85070939843 (Tokushima University Institutional Repository: 115182, DOI: 10.1007/s10753-019-01079-x, PubMed: 31440939, Elsevier: Scopus)
15.	Keiko Aota, Kohichi Kani, Tomoko Yamanoi, Yukihiro Momota, Masami Ninomiya, Hiromichi Yumoto and Masayuki Azuma : Management of tooth extraction in a patient with ELANE gene mutation-induced cyclic neutropenia: A case report., Medicine, Vol.98, No.39, e17372, 2019. (Summary) Cyclic neutropenia (CyN) is a rare hematological disease, and patients with CyN often experience an early onset of severe periodontitis and are forced to undergo tooth extraction. Here, we report a case of a patient with CyN who showed different periodicity and oscillations of neutrophil count compared with her mother, despite sharing the same novel genetic mutation. A 17-year-old Japanese girl who had been diagnosed with CyN shortly after birth presented to our hospital with a complaint of mobility of her teeth and gingivitis. Upon presentation, an intraoral examination was performed and revealed redness and swelling of the marginal and attached gingiva. Radiographs revealed extreme resorption of the alveolar bone and apical lesions in her mandibular lateral incisors. The patient's hematologic data demonstrated a lack of blood neutrophils (0/μL). The patient had no history of dental extraction, and her mother also had a history of CyN. The patient was diagnosed with severe periodontitis that was associated with CyN. Gene testing showed a novel heterozygous mutation in exon 4 of the ELANE gene (c.538delC, p.Leu180Ser fsX11). Based on the clinical findings, we planned to extract the patient's mandibular lateral incisors. Although the tooth extraction was scheduled considering the cyclic variation in neutrophil count, the patient's neutrophil count was 0/μL on the day before the planned extraction. Therefore, granulocyte-colony stimulating factor (G-CSF) was administered to increase the patient's neutrophil count. On the day of the patient's admission for the tooth extraction, she presented with fever (body temperature, 38.5°C), tonsillitis, and stomatitis. The extraction was subsequently delayed, and the patient was administered antibiotics and G-CSF for 4 days. At this time, the neutrophil count increased to 750/μL, and the tooth extraction was carried out safely. The postoperative course was uneventful, and the healing process at the extraction site was excellent. There is a possibility that the periodicity and oscillations of neutrophil count may change with growth in patients with CyN. Therefore, it is important to frequently examine and treat patients with fluctuating neutrophil levels for the management of invasive dental treatment in patients with CyN. (Keyword) Adolescent / Exons / female / Humans / Leukocyte Count / Leukocyte Elastase / Mutation / Neutropenia / Neutrophils / periodontitis / Tooth Extraction (Tokushima University Institutional Repository) ● Metadata: 115183 (Link to Publication Site) ● Publication site (DOI): 10.1097/MD.0000000000017372 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31574885 ● Summary page in Scopus @ Elsevier: 2-s2.0-85072847226 (Tokushima University Institutional Repository: 115183, DOI: 10.1097/MD.0000000000017372, PubMed: 31574885, Elsevier: Scopus)
16.	Yukihiro Momota, Keiko Aota, Hideyuki Takano, Kohichi Kani and Masayuki Azuma : Concomitant Pregabalin and Tramadol Hydrochloride/Acetaminophen Formulation Relieved Neuropathic Itch of Gingiva: A Case Report., IOSR Journal of Dental and Medical Sciences, Vol.17, No.12, 68-71, 2018. (Link to Publication Site) ● Publication site (DOI): 10.9790/0853-1712036871 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.9790/0853-1712036871 (DOI: 10.9790/0853-1712036871)
17.	Aya Ushio, Rieko Arakaki, Kunihiro Ohtsuka, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, Keiko Aota, Masayuki Azuma and Naozumi Ishimaru : CCL22-Producing Resident Macrophages Enhance T Cell Response in Sjögren's Syndrome., Frontiers in Immunology, Vol.9, 2594, 2018. (Summary) Macrophages (MΦs) are critical regulators of immune response and serve as a link between innate and acquired immunity. The precise mechanism of involvement of tissue-resident MΦs in the pathogenesis of autoimmune diseases is not clear. Here, using a murine model for Sjögren's syndrome (SS), we investigated the role of tissue-resident MΦs in the onset and development of autoimmunity. Two unique populations of CD11b and CD11b resident MΦs were observed in the target tissue of the SS model. Comprehensive gene expression analysis of chemokines revealed effective production of CCL22 by the CD11b MΦs. CCL22 upregulated the migratory activity of CD4 T cells by increasing CCR4, a receptor of CCL22, on T cells in the SS model. In addition, CCL22 enhanced IFN-γ production of T cells of the SS model, thereby suggesting that CCL22 may impair the local immune tolerance in the target organ of the SS model. Moreover, administration of anti-CCL22 antibody suppressed autoimmune lesions in the SS model. Finally, histopathological analysis revealed numerous CCL22-producing MΦs in the minor salivary gland tissue specimens of the SS patients. CCL22-producing tissue-resident MΦs may control autoimmune lesions by enhancing T cell response in the SS model. These results suggest that specific chemokines and their receptors may serve as novel therapeutic or diagnostic targets for SS. (Tokushima University Institutional Repository) ● Metadata: 113526 (Link to Publication Site) ● Publication site (DOI): 10.3389/fimmu.2018.02594 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30467506 ● Summary page in Scopus @ Elsevier: 2-s2.0-85056303968 (Tokushima University Institutional Repository: 113526, DOI: 10.3389/fimmu.2018.02594, PubMed: 30467506, Elsevier: Scopus)
18.	Keiko Aota, Kohichi Kani, Tomoko Yamanoi, Koh-ichi Nakashiro, Naozumi Ishimaru and Masayuki Azuma : Distinct Regulation of CXCL10 Production by Cytokines in Human Salivary Gland Ductal and Acinar Cells., Inflammation, Vol.41, No.4, 1172-1181, 2018. (Summary) CXCL10, a CXC chemokine induced by interferon-gamma [IFN-γ], has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions. Although CXCL10 is known to be overexpressed in the salivary glands of individuals with primary Sjögren's syndrome (pSS), it is unclear which cells produce CXCL10 under what types of stimulations. Here, we investigated the precise molecular mechanisms by which CXCL10 was produced in human salivary gland ductal (NS-SV-DC) and acinar (NS-SV-AC) cell lines. Our results demonstrated that NS-SV-DC cells produced higher levels of CXCL10 compared to NS-SV-AC cells. In addition, our findings demonstrated that the regulator of the enhancement of CXCL10 was different between NS-SV-DC and NS-SV-AC cells, i.e., interferon-gamma (IFN-γ) had more potential than interferon-alpha (IFN-α), tumor necrosis factor (TNF)-α, and interleukin (IL)1-β in the induction of CXCL10 production in NS-SV-DC cells, whereas TNF-α had potential to induce CXCL10 production in NS-SV-AC cells. A Western blot analysis demonstrated that IFN-γ enhanced the production of CXCL10 via both the JAK/STAT1 pathway and the NF-κB pathway in NS-SV-DC cells, whereas TNF-α enhanced the production of CXCL10 via the NF-κB pathway in NS-SV-AC cells. The results of study suggest that the CXCL10 overexpression in the salivary glands is caused mainly by IFN-γ-stimulated salivary gland ductal cells. The enhanced production of CXCL10 by IFN-γ from ductal cells may result in the inflammation of pSS lesions. (Keyword) Acinar Cells / Cell Line / Chemokine CXCL10 / Cytokines / Humans / Interferon-gamma / NF-kappa B / Salivary Glands / Tumor Necrosis Factor-alpha (Tokushima University Institutional Repository) ● Metadata: 112923 (Link to Publication Site) ● Publication site (DOI): 10.1007/s10753-018-0764-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29549479 ● Summary page in Scopus @ Elsevier: 2-s2.0-85044090734 (Tokushima University Institutional Repository: 112923, DOI: 10.1007/s10753-018-0764-0, PubMed: 29549479, Elsevier: Scopus)
19.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, Koh-ichi Nakashiro, Naozumi Ishimaru and Masayuki Azuma : Inverse correlation between the number of CXCR3+ macrophages and the severity of inflammatory lesions in Sjögren's syndrome salivary glands: a pilot study, Journal of Oral Pathology & Medicine, Vol.47, No.7, 710-718, 2018. (Summary) Mechanisms underlying immune cells' recruitment and activation into the inflammatory lesions of lip salivary glands (LSGs) from primary Sjögren's syndrome (pSS) patients are incompletely understood. Chemokines play pivotal roles in these processes, so we investigated the clinical significance of chemokine receptor CXCR3 and its ligands in the autoimmune lesions of pSS. We histologically determined the grade of LSG samples from 22 patients with pSS and subjected the samples to immunofluorescence analysis to determine the expressions of CXCR3 and its ligands: CXCL9, CXCL10, and CXCL11. To identify the immune cells expressing CXCR3 in the LSGs, we performed double immunofluorescence analysis using antibodies against CD3 (pan-T cells), CD80 (M1 macrophages), CD163 (M2 macrophages), and CD123 (plasmacytoid dendritic cells: pDCs). The relationship between the grade of lymphocytic infiltration and the number of positively stained cells was analyzed by Spearman's rank correlation test. The expressions of CXCL9 and CXCL10 showed particularly intense staining in the LSG samples' ductal cells. The CXCR3 expression was detected mainly in CD80 and CD163 macrophages. The number of CXCR3 CD163 macrophages inversely correlated with the LSG inflammatory lesions' severity (rs = -0.777, P < 0.001). Our results suggest that the enhanced production of CXCL9 and CXCL10 from ductal cells results in the CXCR3 macrophages' migration. There was an inverse correlation between these two parameters: that is, the number of CXCR3 CD163 macrophages decreased as the lymphocytic infiltration grade increased. Although CXCR3 is expressed in all of the innate immune cells, CXCR3 CD163 M2 macrophages may contribute to the anti-inflammatory functions in pSS lesions. (Tokushima University Institutional Repository) ● Metadata: 113977 (Link to Publication Site) ● Publication site (DOI): 10.1111/jop.12756 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29926992 ● Summary page in Scopus @ Elsevier: 2-s2.0-85050503684 (Tokushima University Institutional Repository: 113977, DOI: 10.1111/jop.12756, PubMed: 29926992, Elsevier: Scopus)
20.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, 高瀬奈緒, 宮本由貴, Shinji Ono and Masayuki Azuma : 一次性舌痛症における唾液アミラーゼ活性測定の試み, Journal of Japanese Society for Evidence and the Dental Professional, Vol.10, No.1, 64-67, 2018. (Keyword) 一次性舌痛症 / 唾液アミラーゼ活性 / 近赤外線星状神経節近傍照射 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050845762642423424 (CiNii: 1050845762642423424)
21.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Keiko Aota, Tomoko Yamanoi and Masayuki Azuma : Docetaxel・γ-tocotrienol併用療法による口腔癌移植ヌードマウス腫瘍への抗腫瘍効果の検討．, The Japanese Journal of Tissue Culture Society for Dental Research, Vol.27, No.1, 19-20, 2018.
22.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani and Masayuki Azuma : Cepharanthine inhibits IFN--induced CXCL10 by suppressing the JAK2/STAT1 signal pathway in human salivary gland ductal cells, Inflammation, Vol.41, No.1, 50-58, 2018. (Summary) Cepharanthine, a biscolaurine alkaloid isolated from the plant Stephania cephalantha Hayata, has been reported to have potent anti-inflammatory properties. Here, we investigated the effects of cepharanthine on the expression of CXCL10 (a CXC chemokine induced by interferon-gamma [IFN-γ] that has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions) in IFN-γ-treated human salivary gland cell lines. We observed that IFN-γ-induced CXCL10 production in NS-SV-DC cells (a human salivary gland ductal cell line), but not in NS-SV-AC cells (a human salivary gland acinar cell line). Cepharanthine inhibited the IFN-γ-induced CXCL10 production in NS-SV-DC cells. A Western blot analysis showed that cepharanthine prevented the phosphorylation of JAK2 and STAT1, but did not interfere with the NF-κB pathway. Moreover, cepharanthine inhibited the IFN-γ-mediated chemotaxis of Jurkat T cells. These results suggest that cepharanthine suppresses IFN-γ-induced CXCL10 production via the inhibition of the JAK2/STAT1 signaling pathway in human salivary gland ductal cells. Our findings also indicate that cepharanthine could inhibit the chemotaxis of Jurkat T cells by reducing CXCL10 production. (Tokushima University Institutional Repository) ● Metadata: 112922 (Link to Publication Site) ● Publication site (DOI): 10.1007/s10753-017-0662-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28879548 ● Search Scopus @ Elsevier (PMID): 28879548 ● Search Scopus @ Elsevier (DOI): 10.1007/s10753-017-0662-x (Tokushima University Institutional Repository: 112922, DOI: 10.1007/s10753-017-0662-x, PubMed: 28879548)
23.	Keiko Aota, Tomoko Yamanoi, Hideyuki Takano, Kohichi Kani, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : 徳島大学病院歯科診療所を受診したHIV感染症患者の臨床統計的検討, Journal of Japanese Society of Dentistry for Medically Compromised Patient, Vol.26, No.6, 444-450, 2017. (Tokushima University Institutional Repository) ● Metadata: 113552 (Tokushima University Institutional Repository: 113552)
24.	Tomoko Yamanoi, Keiko Aota, Yukihiro Momota and Masayuki Azuma : Treatment with the Biscoclaurine Alkaloid Cepharanthin Significantly Increases Salivary Selection in Primary Sjögren's Syndrome Patients, Journal of Oral Health and Biosciences, Vol.29, No.2, 39-48, 2017. (Tokushima University Institutional Repository) ● Metadata: 111058 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.29.2_39 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.20738/johb.29.2_39 (Tokushima University Institutional Repository: 111058, DOI: 10.20738/johb.29.2_39)
25.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, 高瀬奈緒, Yuki Miyamoto, Shinji Ono, Shigemasa Tomioka and Masayuki Azuma : A Case Series of Xerostomia Treated with Kampo Medicines: Assessment of Health-Related Quality of Life Based on the Japanese Version of the Short Form-8 Health Survey, Oral Science in Japan, Vol.2017, 79-82, 2017. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520572359919321344 (CiNii: 1520572359919321344)
26.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, 高瀬奈緒, 宮本由貴, Shinji Ono and Masayuki Azuma : Orofacial Pain Well-Treated with Triple-Drug Combination : A Case Series, Japanese Journal of Orofacial Pain, Vol.9, No.1, 53-59, 2016. (Keyword) 三剤併用，口腔顔面痛，プレガバリン，トラマドール塩酸塩/アセトアミノフェン配合錠，加工附子末製剤 (Link to Publication Site) ● Publication site (DOI): 10.11264/jjop.9.53 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11264/jjop.9.53 (DOI: 10.11264/jjop.9.53)
27.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 山ノ井朋子, 近藤智香, 高瀬奈緒, 宮本由貴 and Masayuki Azuma : Usability Survey on New Oral Care Products, Pepti-Sal Series, Oral Care, Vol.11, No.1, 87-89, 2016. (Keyword) 市販保湿剤 / 使用感 / 口腔乾燥 / Oral care products / Usability survey / Xerostomia (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1523669555912256384 (CiNii: 1523669555912256384)
28.	Yoshiko Yamamura, Hiromitsu Takizawa, Fumihiro Matsumoto, Yukihiro Momota, Keiko Aota, Daisuke Takegawa, 近藤智香, 山ノ井朋子, Hideyuki Takano, Kohichi Kani, 十川悠香, Fumiaki Kawano, Takashi Matsuo, Shoji Sakiyama and Masayuki Azuma : Effects of perioperative oral management in thoracoscopic lung lobectomy : Retrospective study, Oral Care, Vol.10, No.1, 106-110, 2016. (Keyword) 胸腔鏡下肺葉切除術 / 周術期口腔機能管理 / 術後合併症 / thoracoscopic lung lobectomy / Perioperative oral management / postoperative complications (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522262181026542720 (CiNii: 1522262181026542720)
29.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Yamanoi Tomoko, Kondo Chika, Takase Nao, Miyamoto Yuki, Shigemasa Tomioka and Masayuki Azuma : Significance of Time-Domain Measurements of Heart Rate Variability in Burning Mouth Syndrome, IOSR Journal of Dental and Medical Sciences, Vol.15, No.1, 25-33, 2016.
30.	Fumihiro Matsumoto, Yukihiro Momota, Hideyuki Takano, Keiko Aota, Kohichi Kani, Chika Kondo, Tomoko Yamanoi, Nao Takase, Yuki Miyamoto, Shinji Ono, Yoshiko Yamamura and Hidehiko Hosoki : Severe Posterior Open Bite by Posterior Folding of the Retrodiscal Tissue: A Case Report, IOSR Journal of Dental and Medical Sciences, Vol.14, No.10, 27-31, 2015. (Keyword) Magnetic resonance image / Posterior folding of the retrodiscal tissue / Posterior open bite / Pumping manipulation technique / Temporomandibular joint (Link to Publication Site) ● Publication site (DOI): 10.9790/0853-141052731 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.9790/0853-141052731 (DOI: 10.9790/0853-141052731)
31.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Yamanoi Tomoko, Kondo Chika, Takase Nao, Miyamoto Yuki and Masayuki Azuma : Study on Health-Related Quality of Life in Patients with Primary Glossodynia : Using the Japanese Version of the MOS 36-Item Short-Form Health Survey Version 2, Journal of Japanese Society of Oral Medicine, Vol.21, No.1, 9-14, 2015. (Summary) Primary glossodynia is characterized by abnormal sensations such as tongue pain without pathological changes and is not fully understood. The Japanese version of the MOS 36-item short-form health survey version 2 (SF-36v2) is a questionnaire to measure health-related quality of life (HRQoL) in various diseases. We studied HRQoL in 26 primary glossodynia patients who self-completed the SF-36v2. The mean scores on the SF-36v2 subscales in our female patients were significantly lower than the national norms. Furthermore, those in the elderly female patients were significantly lower than those in the middle-aged ones. Conditions of primary glossodynia in the elderly patients were complicated by physical and mental factors; psychosocial supports should be required for their care in addition to pain control. Our study of HRQoL in primary glossodynia patients using the SF-36v2 was shown to be meaningful for understanding primary glossodynia and establishing goals for its care. (Keyword) 一次性舌痛症 / 健康関連QOL / SF-36v2 / primary glossodynia / health-related quality of life / MOS 36-item short-from health survey version 2 (Link to Publication Site) ● Publication site (DOI): 10.6014/jjsom.21.9 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205424141312 ● Search Scopus @ Elsevier (DOI): 10.6014/jjsom.21.9 (DOI: 10.6014/jjsom.21.9, CiNii: 1390001205424141312)
32.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, Chika Kondo, Nao Takase, Yuki Miyamoto, Shigemasa Tomioka and Masayuki Azuma : A Case Series of Burning Mouth Syndrome Treated with Stellate Ganglion Near-Infrared Irradiation: Assessment of HealthRelated Quality of Life Based on the Japanese Version of the MOS 36-Item Short-Form Health Survey Version 2, IOSR Journal of Dental and Medical Sciences, Vol.14, No.6, 39-43, 2015. (Link to Publication Site) ● Publication site (DOI): 10.9790/0853-14643943 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.9790/0853-14643943 (DOI: 10.9790/0853-14643943)
33.	Yoshiko Yamamura, Keiko Aota, Yukihiro Momota, Fumihiro Matsumoto, Kojiro Nagai and Masayuki Azuma : Oral management of patients with chronic kidney diseases in the Tokushima University Hospital, Oral Care, Vol.9, No.1, 23-27, 2015. (Keyword) 慢性腎臓病 / ステロイド治療 / ビスフォスフォネート製剤 / chronic kidney diseases / steroid preparation / bisphosphonate preparation (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1524232505861982208 (CiNii: 1524232505861982208)
34.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, Keiko Aota, Yoshiko Yamamura, Yamanoi Tomoko and Masayuki Azuma : γ-tocotrienol prevents 5-FU-induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5-FU-induced activation of Nrf2, International Journal of Oncology, Vol.46, No.4, 1453-1460, 2015. (Summary) Chemotherapy induced oral mucositis is a common adverse event in patients with oral squamous cell carcinoma, and is initiated through a variety of mechanisms, including the generation of reactive oxygen species (ROS). In this study, we examined the preventive effect of γ tocotrienol on the 5 FU induced ROS production in human oral keratinocytes (RT7). We treated RT7 cells with 5 FU and γ tocotrienol at concentrations of 10 µg/ml and 10 nM, respectively. When cells were treated with 5 FU alone, significant growth inhibition was observed as compared to untreated cells. This inhibition was, in part, due to the ROS gene rated by 5 FU treatment, because N acetyl cysteine (NAC), a ROS scavenger, significantly ameliorated the growth of RT7 cells. γ tocotrienol showed no cytotoxic effect on the growth of RT7 cells. Simultaneous treatment of cells with these agents resulted in the significant recovery of cell growth, owing to the suppression of ROS generation by γ tocotrienol. Whereas 5 FU stimulated the expression of NF E2 related factor 2 (Nrf2) protein in the nucleus up to 12 h after treatment of RT7 cells, γ tocotrienol had no obvious effect on the expression of nuclear Nrf2 protein. Of note, the combined treatment with both agents stabilized the 5 FU induced nuclear Nrf2 protein expression until 24 h after treatment. In addition, expression of Nrf2 dependent antioxidant genes, such as heme oxygenase 1 (HO 1) and NAD(P)H:quinone oxidoreductase 1 (NQO 1), was significantly augmented by treatment of cells with both agents. These findings suggest that γ tocotrienol could prevent 5 FU induced ROS generation by stabilizing Nrf2 activation, thereby leading to ROS detoxification and cell survival in human oral keratinocytes. (Tokushima University Institutional Repository) ● Metadata: 109341 (Link to Publication Site) ● Publication site (DOI): 10.3892/ijo.2015.2849 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25625649 ● Summary page in Scopus @ Elsevier: 2-s2.0-84923112564 (Tokushima University Institutional Repository: 109341, DOI: 10.3892/ijo.2015.2849, PubMed: 25625649, Elsevier: Scopus)
35.	Keiko Aota, Yoshiko Yamamura, 山ノ井朋子, Daisuke Takegawa, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, Fumihiro Matsumoto, Chieko Sugawara, Masami Yoshioka, Fumiaki Kawano, Takashi Matsuo and Masayuki Azuma : Current Status and Problems Regarding the Perioperative Oral Function Management in the Tokushima University Hospital, Journal of Oral Health and Biosciences, Vol.28, No.1, 29-36, 2015. (Summary) It has been shown that oral hygiene affects the onset of perioperative complications. The usefulness of perioperative oral function management aiming at the outbreak decrease in treatment complications and an early discharge was recognized. As a result, perioperative oral function management fee was founded at revision of medical service fees in Fiscal year 2012. In this clinical study, we evaluated the implementation of perioperative oral function management in Tokushima University Hospital. We examined 781 patients, including 563 patients for surgery and 218 patients for chemotherapy and radiotherapy. The mean age of patients was 58.8 ± 12.4 years old. The implementation rate of perioperative oral function management was 9.7% in the patients of surgery, and 17.4% in those of chemotherapy and radiotherapy. The highly required medical department was neurosurgery in the patients of surgery, and hematology in those of chemotherapy and radiotherapy. The mean number of tooth present was 21.3 ± 7.1 in the patients of surgery, and 19.8 ± 7.2 in those chemotherapy and radiotherapy. The rate of dental treatment was required in 40.5% of total patients who received surgery, and in 51.4% of patients who received chemotherapy and radiotherapy.The rate of patients who received denture treatment attained to 11.9% of the whole patients receiving surgery, and 13.3% of patients receiving chemotherapy and radiotherapy. It was revealed that there were many patients required potential demands in perioperative oral function management, and that there were many patients who need dental or denture treatment. We would like to develop perioperative oral function management by the interprofessional collaboration in health and social care.7月発行だが，6月号である． (Keyword) 徳島大学病院 / 周術期口腔機能管理 / チーム医療 (Tokushima University Institutional Repository) ● Metadata: 109866 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050020697877562496 (Tokushima University Institutional Repository: 109866, CiNii: 1050020697877562496)
36.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Keiko Aota, 山ノ井朋子 and Masayuki Azuma : 口腔癌担癌ヌードマウスに対するdocetaxelおよびγ-tocotrienolの併用による抗腫瘍効果の検討, 日口組織培養誌, Vol.24, No.2, 23-30, 2015.
37.	Yoshiko Yamamura, Keiko Aota, Daisuke Takegawa, 十川悠香, 近藤智香, 山ノ井朋子, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Yukihiro Momota, Junichiro Satomi, Fumiaki Kawano, Takashi Matsuo, Shinji Nagahiro and Masayuki Azuma : 徳島大学病院脳卒中センターにおける口腔管理の意義について, Journal of Oral Health and Biosciences, Vol.9, No.1, 37-41, 2015.
38.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Daisuke Takegawa, Yamanoi Tomoko, Kondo Chika, Shigemasa Tomioka and Masayuki Azuma : High-Wattage Pulsed Irradiation of Linearly Polarized Near-Infrared Light to Stellate Ganglion Area for Burning Mouth Syndrome, Case Reports in Dentistry, 2014. (Summary) The purpose of this study was to apply high-wattage pulsed irradiation of linearly polarized near-infrared light to the stellate ganglion area for burning mouth syndrome (BMS) and to assess the efficacy of the stellate ganglion area irradiation (SGR) on BMS using differential time-/frequency-domain parameters (D parameters). Three patients with BMS received high-wattage pulsed SGR; the response to SGR was evaluated by visual analogue scale (VAS) representing the intensity of glossalgia and D parameters used in heart rate variability analysis. High-wattage pulsed SGR significantly decreased the mean value of VAS in all cases without any adverse event such as thermal injury. D parameters mostly correlated with clinical condition of BMS. High-wattage pulsed SGR was safe and effective for the treatment of BMS; D parameters are useful for assessing efficacy of SGR on BMS. (Link to Publication Site) ● Publication site (DOI): 10.1155/2014/171657 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25386367 ● Search Scopus @ Elsevier (PMID): 25386367 ● Search Scopus @ Elsevier (DOI): 10.1155/2014/171657 (DOI: 10.1155/2014/171657, PubMed: 25386367)
39.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Daisuke Takegawa, 山ノ井朋子, 近藤智香 and Masayuki Azuma : 一次性舌痛症における手掌部発汗の発現-皮膚水分量測定の有用性について-, 日本歯科人間ドック学会誌, Vol.9, 18-23, 2014.
40.	Keiko Aota and Masayuki Azuma : Targeting TNF- suppresses the production of MMP-9 in human salivary gland cells., Archives of Oral Biology, Vol.58, No.12, 1761-1768, 2013. (Summary) Tumour necrosis factor- (TNF-) is a pleiotropic cytokine that plays an essential role in inflammation and apoptosis. Our previous study suggested that TNF--induced activation of matrix metalloproteinase-9 (MMP-9) resulted in the destruction of acinar tissue in the salivary glands of patients with Sjögren's syndrome (SS) via disruption of the acinar cell-basement membrane. Recently, a wide array of biological agents has been designed to inhibit TNF, including etanercept and adalimumab. In this study, we demonstrate the suppressive effect of anti-TNF agents on TNF--induced MMP-9 production in NS-AV-AC, an immortalized human salivary gland acinar cell line. NS-AV-AC cells were treated with etanercept or adalimumab after TNF- treatment. MMP-9 production and enzymatic activity were, respectively, visualized by real-time PCR and ELISA assay, and evaluated by gelatin zymography, and apoptosis was evaluated by DNA fragmentation assay. TNF- induced the production of MMP-9 in NS-SV-AC cells. However, this production was greatly inhibited by treatment with etanercept or adalimumab. In addition, TNF--induced DNA fragmentation was prevented by treatment with etanercept or adalimumab. These results may indicate that anti-TNF agents would have therapeutic efficacy for preventing destruction of the acinar structure in the salivary glands of patients with SS. (Keyword) Acinar Cells / Antibodies, Monoclonal, Humanized / Antirheumatic Agents / Apoptosis / Cell Line / DNA Fragmentation / Electrophoresis, Polyacrylamide Gel / Enzyme-Linked Immunosorbent Assay / Gene Expression / Humans / Immunoglobulin G / Matrix Metalloproteinase 9 / RNA, Messenger / Real-Time Polymerase Chain Reaction / Receptors, Tumor Necrosis Factor / Salivary Glands / Sjogren's Syndrome / Tumor Necrosis Factor-alpha (Tokushima University Institutional Repository) ● Metadata: 113553 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.archoralbio.2013.09.004 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24200302 ● Search Scopus @ Elsevier (PMID): 24200302 ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2013.09.004 (Tokushima University Institutional Repository: 113553, DOI: 10.1016/j.archoralbio.2013.09.004, PubMed: 24200302)
41.	Keiko Aota, Yoshiko Yamamura, Kohichi Kani, Hideyuki Takano, Katsumi Motegi, Yukihiro Momota, Naozumi Ishimaru and Masayuki Azuma : Prevention of the destruction of acinar structure in patients with Sjogren's syndrome : Clinicopathological study on the effectiveness of cepharanthin, Journal of The Japanese Stomatological Society, Vol.62, No.4, 254-261, 2013. (Summary) Sjögren's syndrome (SS) is characterized by the eventual total replacement of the acinar structure by marked infiltration of lymphocytes into the salivary and lacrimal glands. We previously demonstrated that tumor necrosis factor-α (TNF-α) induced matrix metalloproteinase-9 (MMP-9) production by the stimulating transcription factor, nuclear factor-κB (NF-κB), in human salivary gland acinar cells and that cepharanthin, a biscoclaurine alkaloid, prevented the activation of TNF-α-induced NF-κB activity. In addition, we have shown that cepharanthin prevented the destruction of acinar tissues in murine SS. Thus, in this study, we investigated the clinicopathological effect of cepharanthin on the patients with SS. <br>Ten patients with a diagnosis of primary SS were enrolled in this study. They were treated with cepharanthin for three months, followed by the evaluation of salivary production, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-SS-A antibody, anti-SS-B antibody, pathological examination of labial salivary gland biopsy specimens, and the symptom of drymouth. <br>Average salivary production was 4.25ml/10minutes before the study. This average production increased to 6.46ml/10minutes after the study. There were no remarkable changes in CRP, ESR, anti-SS-A antibody and anti-SS-B antibody. In pathological findings, although the decreases in infiltration of lymphocytes were observed in 5 out of 5 cases, the reduction of destruction of acinar structures was clearly detected in 5 cases. Improvement of symptom of drymouth was detected in 7 out of 10 cases. <br>These observations suggest that cepharanthin treatment might provide an efficient and useful therapeutic approach for countering the destruction of acinar tissue in salivary glands of patients with SS. (Keyword) Sjogren'ssyndrome(Sjogren症候群) / cepharanthin(セファランチン) / salivaryglandacinarcell(唾液腺腺房細胞) (Link to Publication Site) ● Publication site (DOI): 10.11277/stomatology.62.254 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001206436002048 ● Search Scopus @ Elsevier (DOI): 10.11277/stomatology.62.254 (DOI: 10.11277/stomatology.62.254, CiNii: 1390001206436002048)
42.	Keiko Aota, Hideyuki Takano, Hiroyoshi Hosokawa, Kohichi Kani, Yoshiko Yamamura and Masayuki Azuma : A case of oral, pharyngeal, esophageal, and gastric ulcer in a patient with primary macroglobulinemia showing remission by treatment with rituximab, Japanese Journal of Oral & Maxillofacial Surgery, Vol.59, No.7, 478-482, 2013. (Keyword) rituximab(リツキシマブ) / oral,pharyngeal,esophageal,andgastriculcer(口腔・咽頭・食道・胃潰瘍) / delayed-onsetneutropenia(遅発性好中球減少症) / Waldenstrommacroglobulinemia(原発性マクログロプリン血症) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001206533368832 (CiNii: 1390001206533368832)
43.	Yukihiro Momota, Hiroyoshi Hosokawa, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura, Mayuko Ohmori and Masayuki Azuma : 口腔白板症の臨床病理学的検討-悪性化に関する臨床病理学的指標について-, Journal of Japanese Society for Evidence and the Dental Professional, Vol.5, No.1, 26-30, 2013. (Keyword) oral leukoplakia / epithelial dysplasia / malignant transformation (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050001337712179328 (CiNii: 1050001337712179328)
44.	Yoshiko Yamamura, Yukihiro Momota, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Hideyuki Takano, Mayuko Ohmori, Fumiaki Kawano and Masayuki Azuma : Current state of request for Oral Care in the Tokushima University Hospital, Oral Care, Vol.7, No.1, 31-35, 2013. (Keyword) medically compromised patient / oral care / dental intervention (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522543656003631232 (CiNii: 1522543656003631232)
45.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura, Mayuko Omori, Shigemasa Tomioka and Masayuki Azuma : Frequency analysis of heart rate variability: a useful assessment tool of linearly polarized near-infrared irradiation to stellate ganglion area for burning mouth syndrome., Pain Medicine, Vol.14, No.3, 351-357, 2013. (Summary) Burning mouth syndrome (BMS) is characterized by the following subjective complaints without distinct organic changes: burning sensation in mouth or chronic pain of tongue. BMS is also known as glossodynia; both terms are used equivalently in Japan. Although the real cause of BMS is still unknown, it has been pointed out that BMS is related to some autonomic abnormality, and that stellate ganglion near-infrared irradiation (SGR) corrects the autonomic abnormality. Frequency analysis of heart rate variability (HRV) is expected to be useful for assessing autonomic abnormality. This study investigated whether frequency analysis of HRV could reveal autonomic abnormality associated with BMS, and whether autonomic changes were corrected after SGR. Eight subjects received SGR; the response to SGR was assessed by frequency analysis of HRV. No significant difference of autonomic activity concerning low-frequency (LF) norm, high-frequency (HF) norm, and low-frequency/high-frequency (LF/HF) was found between SGR effective and ineffective groups. Therefore, we proposed new parameters: differential normalized low frequency (D LF norm), differential normalized high frequency (D HF norm), and differential low-frequency/high-frequency (D LF/HF), which were defined as differentials between original parameters just before and after SGR. These parameters as indexes of responsiveness of autonomic nervous system (ANS) revealed autonomic changes in BMS, and BMS seems to be related to autonomic instability rather than autonomic imbalance. Frequency analysis of HRV revealed the autonomic instability associated with BMS and enabled tracing of autonomic changes corrected with SGR. It is suggested that frequency analysis of HRV is very useful in follow up of BMS and for determination of the therapeutic efficacy of SGR. (Keyword) Adult / Aged / Aged, 80 and over / Autonomic Nervous System Diseases / Burning Mouth Syndrome / Female / Heart Rate / Humans / Male / Middle Aged / Stellate Ganglion / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1111/pme.12008 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23240990 ● Summary page in Scopus @ Elsevier: 2-s2.0-84875054662 (DOI: 10.1111/pme.12008, PubMed: 23240990, Elsevier: Scopus)
46.	Kohichi Kani, Yukihiro Momota, Michito Harada, Yoshiko Yamamura, Keiko Aota, Tomoko Yamanoi, Hideyuki Takano, Katsumi Motegi and Masayuki Azuma : γ-tocotrienol enhances the chemosensitivity of human oral cancer cells to docetaxel through the down regulation of the expression of NF-kB-regulated anti-apoptotic gene products., International Journal of Oncology, Vol.42, No.1, 75-82, 2013. (Summary) Taxanes, including docetaxel, are widely used for the treatment of squamous cell carcinoma of the head and neck. However, the gastrointestinal toxicity of docetaxel has limited its high-dose clinical use. In this study, we examined the synergistic anticancer effects of combined low-dose docetaxel and γ-tocotrienol treatment on human oral cancer (B88) cells. We treated B88 cells with docetaxel and γ-tocotrienol at concentrations of 0.5 nM and 50 µM, respectively. When cells were treated with either agent alone at a low dose, no significant cytotoxic effect was observed. However, the simultaneous treatment of cells with both agents almost completely suppressed cell growth. Whereas docetaxel stimulated the expression of nuclear factor-κB (NF-κB) p65 protein in B88 cells, γ-tocotrienol slightly inhibited the expression of constitutive nuclear p65 protein. Of note, the combined treatment with both agents inhibited docetaxel-induced nuclear p65 protein expression. Electrophoretic mobility shift assay (EMSA) revealed that the simultaneous treatment with these agents suppressed the NF-κB DNA binding activity in B88 cells. In addition, γ-tocotrienol downregulated the docetaxel-induced expression of NF-κB-regulated gene products associated with the inhibition of apoptosis. Furthermore, the activation of initiator caspases, caspases-8 and -9, and the effector caspase, caspase-3, was detected following treatment with both agents. Finally, apoptosis was also clearly observed as demonstrated by the cleavage of poly(ADP-ribose) polymerase (PARP) and nuclear fragmentation through the activation of caspase-3 by combined treatment with docetaxel and γ-tocotrienol. These findings suggest that the combination treatment with these agents may provide enhanced therapeutic response in oral cancer patients, while avoiding the toxicity associated with high-dose β-tubulin stabilization monotherapy. (Keyword) Antineoplastic Agents / apoptosis / Apoptosis Regulatory Proteins / Blotting, Western / Caspase 3 / Cell Nucleus / Cell Proliferation / Chromans / Cytoplasm / Down-Regulation / Drug Resistance, Neoplasm / Electrophoretic Mobility Shift Assay / Humans / Mouth Neoplasms / NF-kappa B / Peptide Library / Poly(ADP-ribose) Polymerases / Taxoids / Tumor Cells, Cultured / Vitamin E (Link to Publication Site) ● Publication site (DOI): 10.3892/ijo.2012.1692 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23138939 ● Summary page in Scopus @ Elsevier: 2-s2.0-84873667169 (DOI: 10.3892/ijo.2012.1692, PubMed: 23138939, Elsevier: Scopus)
47.	Keiko Aota, Yoshiko Yamamura, 大守真由子, 山田祐子, Kohichi Kani, Hideyuki Takano, Katsumi Motegi, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : 精神科神経科入院患者の口腔環境評価と専門的口腔ケアの有用性について, 有病者歯科医療, Vol.22, No.2, 83-90, 2013.
48.	Mayuko Ohmori, Keiko Aota, Yoshiko Yamamura, Yuko Yamada, Kohichi Kani, Hideyuki Takano, Katsumi Motegi, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : 徳島大学病院精神科神経科入院患者に対する口腔ケアの意義, Shikoku Dental Research, Vol.25, No.2, 55-60, 2013. (Tokushima University Institutional Repository) ● Metadata: 109829 (Tokushima University Institutional Repository: 109829)
49.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura, 大守真由子 and Masayuki Azuma : Clinical Statistics of Patients with Lingual Abnormalities Including Glossalgia -Clinical Characteristics of Glossodynia-, Japanese Journal of Orofacial Pain, Vol.5, No.1, 27-35, 2012. (Summary) Purpose: There are many kinds of diseases that can cause glossalgia, and it is not always easy to determine the differential diagnosis. Therefore, establishment of screening procedures for organic factors of glossalgia is important to obtain the correct diagnosis. We statistically analyzed the findings in patients with various lingual abnormalities. Methods: Patients were 104 persons consisted of 12 males and 92 females. Medical history taking, intraoral and extraoral examinarion, panoramic x-ray radiography, blood examination, culture, and salivation test were performed. It was also determined whether local analgesic or nonsteroidal anti-inflammatory drug relieved the pain or not. Results: Glossalgia-related diseases consisted of oral candidiasis, xerostomia, glossitis, glossodynia and other diseases. The major part of oral candidiasis lacked a change in organic appearance. Concerning xerostomia, a sense of thirst was also lacking. Local analgesic or nonsteroidal anti-inflammatory drug showed a limited effect on glossodynia. The prevalence of taste disorder or hypozincemia in glossodynia was less than that in other diseases. On the other hand the prevalence of palm sweating in glossodynia was greater than that in other diseases. Conclusions: Culture and salivation test were necessary for the diagnosis of either oral candidiasis without a change in organic appearance or xerostomia without a sense of thirst. If these examinations were not performed, these cases might be diagnosed as glossodynia. The presence of pain on tongue tip and the absence of food-induced pain or oppressive pain were specific findings of glossodynia. Lingual mucous damage could not be directly correlated with pathology of glossodynia judging from the nature of glossalgia and the result of analgesic effects. Taste disorder and hypozincemia were found to be nonspecific findings of glossodynia. It was suggested that glossodynia is related to dysautonomia, and palm sweating is a specific finding of glossodynia. (Keyword) Glossalgia / Glossodynia / Diagnosis (Link to Publication Site) ● Publication site (DOI): 10.11264/jjop.5.27 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205301100160 ● Search Scopus @ Elsevier (DOI): 10.11264/jjop.5.27 (DOI: 10.11264/jjop.5.27, CiNii: 1390001205301100160)
50.	Yukihiro Momota, Katsumi Motegi, Keiko Aota, Hideyuki Takano, Kohichi Kani and Masayuki Azuma : Rapidly-Enlarged and Ruptured Submucous Hematoma of Soft and Hard Palate during Anticoagulation Therapy with Warfarin : A Case Report, Journal of Japanese Society of Oral Medicine, Vol.18, No.2, 68-71, 2012. (Summary) We present a case of rapidly-enlarged and ruptured submucous hematoma of soft and hard palate during warfarin therapy.<br>The Patient was a 76-year old man. He suddenly had palatal swelling and difficulty in breathing while eating, and was brought to us by ambulance. He has been receiving warfarin therapy and treatments for paroxysmal atrial fibrillation, diabetes mellitus and high blood pressure. On blood examination normocytic anemia was diagnosed. Blood coagulation test demonstrated an elevated value (1.52) of PT-INR. The mucous membrane was exfoliated from both soft and hard palate without abnormalities in either respiratory or circulatory status. Immediately, suturing of the mucosa to the submucosal tissue was performed along with astriction. <br>Emphasis should be on soft and hard palatine submucous hematoma as an oral bleeding complication associated with warfarin therapy. (Keyword) ワルファリン / 出血性合併症 / 軟硬口蓋粘膜下血腫 / warfarin / bleeding complication / soft and hard platine submucous hematoma (Link to Publication Site) ● Publication site (DOI): 10.6014/jjsom.18.68 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680400080640 ● Search Scopus @ Elsevier (DOI): 10.6014/jjsom.18.68 (DOI: 10.6014/jjsom.18.68, CiNii: 1390282680400080640)
51.	Yoshiko Yamamura, Katsumi Motegi, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, Keiko Aota, Tomoko Yamanoi and Masayuki Azuma : TNF-a inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation., Journal of Cellular and Molecular Medicine, Vol.16, No.8, 1766-1775, 2012. (Summary) Sjögren's syndrome is a systemic autoimmune disease characterized by reductions in salivary and lacrimal secretions. The mechanisms underlying these reductions remain unclear. We have previously shown that TNF-α plays an important role in the destruction of acinar structures. Here we examined TNF-α's function in the expression of aquaporin (AQP) 5 in human salivary gland acinar cells. Immortalized human salivary gland acinar (NS-SV-AC) cells were treated with TNF-α, and then the expression levels of AQP5 mRNA and protein were analysed. In addition, the mechanisms underlying the reduction of AQP5 expression by TNF-α treatment were investigated. TNF-α-treatment of NS-SV-AC cells significantly suppressed the expression levels of AQP5 mRNA and protein, and reduced the net fluid secretion rate. We examined the expression and activation levels of DNA methyltransferases (Dnmts) in NS-SV-AC cells treated with TNF-α. However, no significant changes were observed in the expression or activation levels of Dnmt1, Dnmt3a or Dnmt3b. Although we also investigated the role of NF-κB activity in the TNF-α-induced suppression of AQP5 expression in NS-SV-AC cells, we detected similar TNF-α suppression of AQP5 expression in non-transfected cells and in a super-repressor form of IκBα cDNA-transfected cell clones. However, interestingly, chromatin immunoprecipitation analysis demonstrated a remarkable decrease in levels of acetylated histone H4 associated with the AQP5 gene promoter after treatment with TNF-α in NS-SV-AC cells. Therefore, our results may indicate that TNF-α inhibition of AQP5 expression in human salivary gland acinar cells is due to the epigenetic mechanism by suppression of acetylation of histone H4. (Keyword) Acetylation / Acinar Cells / Aquaporin 5 / Chromatin / Fluorescent Antibody Technique / Gene Expression Regulation / Histones / Humans / Methyltransferases / NF-kappa B / Promoter Regions, Genetic / RNA, Messenger / salivary glands / Tumor Necrosis Factor-alpha / Water (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1582-4934.2011.01456.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21973049 ● Summary page in Scopus @ Elsevier: 2-s2.0-84864383757 (DOI: 10.1111/j.1582-4934.2011.01456.x, PubMed: 21973049, Elsevier: Scopus)
52.	Yoshiko Yamamura, Keiko Aota, T Yamanoi, Kohichi Kani, H Takano, Yukihiro Momota, Katsumi Motegi and Masayuki Azuma : DNA demethylating agent decitabine increases AQP5 expression and restores salivary function., Journal of Dental Research, Vol.91, No.6, 612-617, 2012. (Summary) Xerostomia is the symptom of oral dryness resulting most frequently, but not exclusively, from salivary gland hypofunction. Because the prevalence of xerostomia may increase with age, it has multiple oral health consequences in aging populations. In the present study, we demonstrate that the in vivo administration of 5-aza-2'-deoxycytidine (5-Aza-CdR; decitabine), a DNA demethylating agent, to the murine aging model C57BL/6CrSlc mice (24 wks old) increased the volumes of salivary flow compared with those of control mice. Western blot analysis and immunohistochemical staining demonstrated the augmented expression of AQP5 protein in the salivary glands of 5-Aza-CdR-treated mice compared with those of control mice. In addition, AQP5 protein expression levels in 5-Aza-CdR-treated old mice (27 wks old) were much higher than those in untreated and young mice (6 wks old). Global methylation levels in the salivary glands were significantly lower in the 5-Aza-CdR-treated mice than in the untreated mice. Moreover, the induction of demethylation in the AQP5 promoter of 5-Aza-CdR-treated mice was stronger than in the control mice. Analysis of our data therefore suggests that a DNA demethylating agent may be a useful drug for restoring hyposalivation in elderly individuals, thereby leading to the resolution of xerostomia. (Keyword) aging / Animals / Aquaporin 5 / Azacitidine / Cell Membrane Permeability / DNA Methylation / DNA Modification Methylases / Female / Gene Expression Regulation / Mice / Mice, Inbred C57BL / Models, Animal / Promoter Regions, Genetic / Saliva / salivary glands / Salivation / Specific Pathogen-Free Organisms / Xerostomia (Link to Publication Site) ● Publication site (DOI): 10.1177/0022034512446343 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22522773 ● Summary page in Scopus @ Elsevier: 2-s2.0-84860815326 (DOI: 10.1177/0022034512446343, PubMed: 22522773, Elsevier: Scopus)
53.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura, Mayuko Ohmori and Masayuki Azuma : 副オトガイ孔を走行する神経様組織の捻除により口唇感覚異常が改善した症候性三叉神経痛の1例-神経学的検査の有用性について-, Journal of Japanese Society for Evidence and the Dental Professional, Vol.4, No.1, 45-48, 2012. (Keyword) accessory mental foramen / neurologic examination / lip paresthesia / symptomatic trigeminal neuralgia (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812688506368 (CiNii: 1050282812688506368)

Academic Paper (Unrefereed Paper):

1.	Keiko Aota : Medical and Oral Care in the 21st Century by the Department of Oral Medicine, --- A novel Therapeutic Strategy for Dry Mouth on the Basis of Molecular Mechanisms Involved in the Onset of the Disease ---, Journal of Oral Health and Biosciences, Vol.36, No.2, 13-21, 2024. (Keyword) Oral Medicine (Tokushima University Institutional Repository) ● Metadata: 119257 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.36.2_13 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.20738/johb.36.2_13 (Tokushima University Institutional Repository: 119257, DOI: 10.20738/johb.36.2_13)
2.	Tomoko Yamanoi, Keiko Aota and Masayuki Azuma : ヒト唾液腺細胞におけるピロカルピン塩酸塩の AQP5 発現に関する研究, The Japanese Journal of Tissue Culture Society for Dental Research, Vol.28, No.1, 21-22, 2019.
3.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 山ノ井朋子, 高瀬奈緒, 宮本由貴, Shinji Ono, 金川裕子 and Masayuki Azuma : 徳島大学病院口腔内科-発足前後5年間における外来・入院患者の臨床統計的観察-, Journal of Japanese Society of Oral Medicine, Vol.22, No.1, 59, 2016.

Review, Commentary:

1.	Hiromichi Yumoto, Keiko Aota and Masami Ninomiya : 歯肉頬移行部の腫瘤, DENTAL DIAMOND, Vol.47, No.1, 25-26, Jan. 2022. (Keyword) 歯肉腫瘤 / 脂肪種
2.	Kazumi Takaishi, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Ohtuka Ryo, Yuki Akazawa, Takamasa Kitamura, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa, Kohichi Kani, Keiko Aota, Yukihiro Momota, Yoshiko Yamamura, Keiko Kudoh, Go Ohe, Tetsuya Tamatani, Youji Miyamoto, Masayuki Azuma, Tsutomu Iwamoto and Hiroshi Kitahata : Dental Treatment under General Anesthesia in Tokushima University Hospital - Safety Management of Disabled Patients with Special Needs during Dental Treatment-, Journal of Oral Health and Biosciences, Vol.31, No.1, 62-67, Jul. 2018. (Summary) We report about general anesthesia for disabled patients with special needs or young children during dental treatment in Tokushima University Hospital. We have administered ambulatory anesthesia or general anesthesia with short-term hospitalization for the patients. In this report, we showed anesthesia as a behavior management technique and the system for the patients who schedule ambulatory anesthesia in our hospital. We indicated the present situation of dental treatment under general anesthesia and supposed the prospects of dental care for the patients with special needs. (Keyword) 全身麻酔 / 障害者 / 日帰り全身麻酔 / 歯科治療 (Tokushima University Institutional Repository) ● Metadata: 111940 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.31.1_62 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390845712973457920 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.31.1_62 (Tokushima University Institutional Repository: 111940, DOI: 10.20738/johb.31.1_62, CiNii: 1390845712973457920)
3.	Kohichi Kani, Yukihiro Momota, Keiko Aota and Masayuki Azuma : 口腔扁平上皮癌に対するNF-κBを分子標的とした新規併用癌化学療法の開発, BIO Clinica, Vol.33, No.2, 74-79, Feb. 2018.
4.	Keiko Aota and Masayuki Azuma : HIV感染症/AIDSによる口腔カンジダ症, The Journal of Dental Hygiene, Vol.35, No.6, 637-639, Jun. 2015.
5.	Keiko Aota : 栄養ケア・マネジメントとしての口腔ケア, The Journal of the Japan Medical Association, Vol.144, No.3, 506, Jun. 2015.

Proceeding of International Conference:

1.	Hideyuki Takano, Makoto Fukui, Natsumi Fujiwara, Yukihiro Momota and Keiko Aota : The usefulness of non-face-to-face clinical practice using smart glasses in dental hygiene student education, The 3rd annual meeting of the International Society of Oral Care, Apr. 2023.
2.	Keiko Aota, Tsuruta Mai, Okamoto Tomomi, Masugi Sachie, Shinji Ono, Kanakawa Hiroko, Hideyuki Takano, Makoto Fukui and Daisuke Hinode : Factors associated with the development of oral mucositis in pharyngeal cancer patients receiving chemoradiotherapy, The 3rd Annual Meeting of the International Society of Oral Care, Apr. 2023.
3.	Keiko Aota : Clinical characteristics of five cases of oral cancer detected by perioperative oral management, The Second Annual Meeting of the International Society of Oral Care, Apr. 2022. (Keyword) perioperative oral management / oral cancer
4.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, N Takase, Hiroko Kanagawa, Tomoko Yamanoi, Yuki Miyamoto, Shigemasa Tomioka and Masayuki Azuma : Intractable Stomatitis Well-Treated with Kampo Medicines: A Case Series, The 13th Asian Congress on Oral and Maxillofacial Surgery, Taipei, Nov. 2018.
5.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, 高瀬奈緒, 宮本由貴, Shinji Ono and Masayuki Azuma : A Case Series of Xerostomia Treated with Kampo Medicines: Assessment of Health-Related Quality of Life Based on the Japanese Version of the Short Form-8 Health Survey, 23rd International Conference on Oral and Maxillofacial Surgery, Hong Kong, Mar. 2017. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ijom.2017.02.1247 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijom.2017.02.1247 (DOI: 10.1016/j.ijom.2017.02.1247)
6.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, Nao Takase, Yuki Miyamoto, Shinji Ono and Masayuki Azuma : Orofacial Pain Well-Treated with Concomitant Pregabalin, Tramadol Hydrochloride, Acetaminophen, and Powdered Processed Aconite Roots: A Case Series, International Congress on Orofacial Pain, Yokohama, Sep. 2016.
7.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura and Masayuki Azuma : Clinical significance of time-domain analysis of heart rate variability in burning mouth syndrome, 96th Annual Meeting Scientific Sessions & Exhibition, Hawaii, Sep. 2014.
8.	Yoshiko Yamamura, Katsumi Motegi, Yukihiro Momota, Keiko Aota, Hideyuki Takano, Kohichi Kani and Masayuki Azuma : A mechanism underlying the constitutive expression of AQP5 in human salivary gland acinar cells, 21st International canference on oral and maxillofacial surgery, Barcelona, Oct. 2013.
9.	Keiko Aota, Yoshiko Yamamura, Mayuko Omori and Masayuki Azuma : Effectiveness of professional oral care for the improvement of oral hygiene in patients with psychiatry neurology., Asean Plus and Tokushima Joint International Conference, Indonesia, Dec. 2012.
10.	Yoshiko Yamamura, Katsumi Motegi, Keiko Aota, Tomoko Yamanoi, Yukihiro Momota and Masayuki Azuma : Mechanism involved in the constitutive expression of AQP5 in human salivary gland acinar cells., Asean Plus and Tokushima Joint International Conference, Indnesia, Dec. 2012.
11.	Yoshiko Yamamura, Keiko Aota, Katsumi Motegi, T Yamanoi, Yukihiro Momota, Hideyuki Takano, Kohichi Kani and Masayuki Azuma : Augmented Expression of Aquaporin 5 in Aging Mice, The 2nd International Joint Symposium on Oral and Dental Sciences in Conjunction with Dental Specialists Seminar, Indonesia, Mar. 2012.
12.	Masayuki Azuma, Katsumi Motegi, Yoshiko Yamamura, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, Keiko Aota and T Yamanoi : TNF-a inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation., Autoimmunity Congress Asia, Vol.1, No.1, 1-5, Singapore, Nov. 2011.

Proceeding of Domestic Conference:

1.	NISHIDA Mari, Kunihiro Otsuka, Mami Sato-Fukuba, Kohei Naniwa, Kohichi Kani, Yukihiro Momota, RUKA Nagao, MATSUZAWA Shigefumi, Aya Ushio, Takaaki Tsunematsu, Naozumi Ishimaru and Keiko Aota : シェーグレン症候群における老化関連B細胞の動態と発生機序の検討, 第32回日本シェーグレン症候群学会学術集会, Sep. 2024.
2.	Mami Sato-Fukuba, Hiroaki Tawara, Takaaki Tsunematsu and Keiko Aota : Association of salivary gland adipocytes and age-related inflammation, 徳島大学先端酵素学研究所シンポジウム, Aug. 2024.
3.	Mami Sato-Fukuba, NISHIDA Mari, Masahiko Watanabe, Kohei Naniwa, Kohichi Kani, Yukihiro Momota and Keiko Aota : 1型糖尿病モデルマウス唾液腺における発現遺伝子の網羅的解析, 第21回日本口腔ケア学会総会・学術大会第4回国際口腔ケア学会総会・学術大会, Apr. 2024.
4.	Keiko Aota, Kohichi Kani, 西田真理, Mami Sato-Fukuba, Kohei Naniwa and Yukihiro Momota : JAK阻害薬バリシチニブは唾液腺導管細胞のIFN-γ誘導性CXCL10発現を抑制する, 第59回日本口腔組織培養学会総会・学術大会, Nov. 2023.
5.	Kohei Naniwa, Mami Sato-Fukuba, 西田真理, 大山博行, Kohichi Kani, Yukihiro Momota and Keiko Aota : 当科における自己免疫性水疱症の臨床的検討, 第68回日本口腔外科学会総会・学術大会, Nov. 2023.
6.	Kohichi Kani, 西田真理, 大山博行, Mami Sato-Fukuba, Kohei Naniwa, Hideyuki Takano, Yukihiro Momota and Keiko Aota : 上唇に発生した嚢胞腺腫の1例, 第68回口腔外科学会総会・学術大会, Nov. 2023.
7.	Mami Sato-Fukuba, Kohei Naniwa, Kohichi Kani, Yukihiro Momota and Keiko Aota : 不明熱を契機にシェーグレン症候群の診断に至った7歳女児例, 第70回 NPO法人日本口腔科学会中国・四国地方部会, Oct. 2023.
8.	Kunihiro Otsuka, Hiroyuki Kondo, Shin-ichi Tsukumo, Aya Ushio, RUKA Nagao, Keiko Aota, Naozumi Ishimaru and Koji Yasutomo : シングルセル解析を基盤としたシェーグレン症候群の病態解明, 第31回日本シェーグレン症候群学会学術集会, Sep. 2023.
9.	Kohichi Kani, 西田真理, Masahiko Watanabe, 大山博行, Mami Sato-Fukuba, Kohei Naniwa, Yukihiro Momota and Keiko Aota : 急激な増大を呈した頬粘膜形質芽細胞性リンパ腫の1例, 第33回日本口腔内科学会・4学会合同学術大会, Sep. 2023.
10.	Kohei Naniwa, 大山博行, 西田真理, Mami Sato-Fukuba, Kohichi Kani, Yukihiro Momota and Keiko Aota : 多形滲出性紅斑の1例, 第52回口腔外科学会中四国支部学術大会, Jul. 2023.
11.	Kohichi Kani, 西田真理, 大山博行, Kohei Naniwa, Yukihiro Momota, Fumihiro Matsumoto and Keiko Aota : 歯痛を初発症状とした傍咽頭間隙原発悪性リンパ腫の1例, 第77回口腔科学会総会, May 2023.
12.	鶴田真生, 清野方子, 田倉幸子, 福島みどり, 岡本知美, 幸江真杉, Shinji Ono, 金川裕子, Hideyuki Takano, Makoto Fukui, Daisuke Hinode and Keiko Aota : 咽頭がん化学放射線療法患者の口腔粘膜炎発症に影響を与える因子に関する研究, 第20回日本口腔ケア学会総会・学術集会, Apr. 2023.
13.	Kohei Naniwa, 金川裕子, Shinji Ono, 西田真理, 大山博行, Kohichi Kani, Fumihiro Matsumoto, Yukihiro Momota, Hideyuki Takano and Keiko Aota : 整形外科インプラント手術における周術期口腔機能管理の有効性の検討, 第20回日本口腔ケア学会総会・学術大会, Apr. 2023.
14.	Keiko Aota, 鶴田真生, 岡本知美, 幸江真杉, Shinji Ono, 金川裕子, Hideyuki Takano, Makoto Fukui and Daisuke Hinode : Factors associated with the development of oral mucositis in pharyngeal cancer patients receiving chemoradiotherapy, 第20回日本口腔ケア学会総会・学術集会, Apr. 2023.
15.	岡本知美, 清野方子, 田倉幸子, 鶴田真生, 福島みどり, 幸江真杉, Shinji Ono, 金川裕子, Hideyuki Takano and Keiko Aota : 当院の脳神経外科における歯科衛生士介入の現状と課題, 第20回日本口腔ケア学会総会・学術集会, Apr. 2023.
16.	Kohei Naniwa, 廣瀬勝俊, 宇佐美悠, 小守壽文, 豊澤悟 and Keiko Aota : 象牙質形成におけるFam20Cによるリン酸化の役割について, 第58回日本口腔組織培養学会学術大会, Dec. 2022.
17.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Shinji Ono and Keiko Aota : γ-tocotrienol前投与によるdocetaxelの口腔扁平上皮癌細胞株に及ぼす抗腫瘍効果の検討, 第67回日本口腔外科学会総会・学術集会, Nov. 2022.
18.	Kohei Naniwa, 西田真理, 大山博行, Hideyuki Takano, Kohichi Kani, Yukihiro Momota, Fumihiro Matsumoto and Keiko Aota : メトトレキサート休薬により良好な結果が得られた医原性リンパ増殖性疾患の一例, 第69回日本口腔科学会中四国地方部会, Oct. 2022.
19.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, NISHIDA Mari, 大山博行, Shinji Ono, Kohei Naniwa, Fumihiro Matsumoto and Keiko Aota : 徳島県における南海トラフ大地震による歯科医院被害予測と大学歯科に期待される役割, 第69回日本口腔科学会中国四国地方部会, Oct. 2022.
20.	Keiko Aota : これまでの診療・研究，そしてこれから, 四国歯学会第60回例会, Jun. 2022.
21.	Kohichi Kani, 中原崇道, 金川裕子, Shinji Ono, Hideyuki Takano, 岡本知美, 幸江真杉, 大山博行, Fumihiro Matsumoto, Yukihiro Momota and Keiko Aota : 周術期口腔機能管理を契機に発見された口腔悪性腫瘍5例の臨床的検討, 徳島大学病院 Cancer board, May 2022.
22.	Keiko Aota, 中原崇道, 金川裕子, 小野伸二, 岡本知美, 幸江真杉, 大山博行, Kohichi Kani, Fumihiro Matsumoto and Yukihiro Momota : 周術期口腔機能管理を契機に発見された口腔悪性腫瘍5例の臨床的検討, 第19回日本口腔ケア学会総会・学術大会, Apr. 2022. (Keyword) 周術期口腔機能管理 / 口腔悪性腫瘍
23.	Hideyuki Takano, Shinji Ono, Hiroko Kanagawa, Fumihiro Matsumoto, Yukihiro Momota, Kohichi Kani, Takamichi Nakahara, 大山博行 and Keiko Aota : 当院における緩和ケア患者に対する口腔機能管理について, 第19回日本口腔ケア学会総会・学術大会, Apr. 2022.
24.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Shinji Ono and Keiko Aota : Docetaxel・γ-tocotrienol時間差投与による口腔扁平上皮癌細胞株に及ぼす抗腫瘍効果の検討, 第76回日本口腔科学会学術集会, Apr. 2022.
25.	Keiko Aota, Kohichi Kani, Yukihiro Momota, Naozumi Ishimaru and Masayuki Azuma : シェーグレン症候群唾液腺におけるJAKsの発現解析, 第76回日本口腔科学会学術集会, Apr. 2022. (Keyword) Sjögren's syndrome / JAK
26.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Shinji Ono, Fumihiro Matsumoto, Takamichi Nakahara, 大山博行 and Keiko Aota : 葛根湯が奏効した特発性first bite syndromeの1例-心拍間変異分析と健康関連QOLの評価について-, 第76回日本口腔科学会学術集会, Apr. 2022.
27.	高原由実子, Hirokazu Miki, Shingen Nakamura, 中村昌史, Ryohei Sumitani, Masahiro Oura, Kimiko Sogabe, 髙橋真美子, 丸橋朋子, 岡本秀樹, Naoto Okada, 矢野由美子, 高橋真理, Takeshi Harada, Shiroh Fujii, Keiko Aota, Shuji Ozaki and Masahiro Abe : HIV感染症および後天性免疫不全症候群患者の臨床的特徴と今後の課題., --- 264 ( 3 ) ---, 第264回徳島医学会学術集会(令和3年度冬期), 2022年2月20日(Web開催), Feb. 2022.
28.	大山博行, Kohichi Kani, 中原崇道, Yukihiro Momota, Fumihiro Matsumoto and Keiko Aota : 口腔内血種を初発症状とした後天性血友病Aの1例, 第50回日本口腔科学会中国四国支部学術集会, Jan. 2022.
29.	Kohichi Kani, Yukihiro Momota, 大山博行, 中原崇道, Fumihiro Matsumoto and Keiko Aota : 肺動静脈瘻を伴ったオスラー病患者に対する抜歯経験の1例, 第50回日本口腔科学会中国四国支部学術集会, Jan. 2022.
30.	中原崇道, 大山博行, Shinji Ono, 金川裕子, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, Fumihiro Matsumoto and Keiko Aota : 周術期口腔機能管理を契機に口腔悪性腫瘍が発見された5例, 第68回日本口腔科学会中国四国地方部会, Nov. 2021. (Keyword) 周術期口腔機能管理 / 口腔悪性腫瘍
31.	Shinji Ono, Hideyuki Takano, Hiroko Kanagawa, Fumihiro Matsumoto, Yukihiro Momota, Kohichi Kani, Takamichi Nakahara, 大山博行 and Keiko Aota : 当院がん化学療法・放射線療法患者におけるエピシル使用実績について, 第68回NPO法人日本口腔科学会中国・四国地方部会, Nov. 2021.
32.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Shinji Ono and Keiko Aota : Docetaxel・γ-tocotrienol併用による口腔扁平上皮癌細胞株に及ぼす抗腫瘍効果の検討, 第66回日本口腔外科学会総会・学術集会, Nov. 2021.
33.	Keiko Aota, Kohichi Kani, Yukihiro Momota, Naozumi Ishimaru and Masayuki Azuma : シェーグレン症候群唾液腺におけるJAK1およびJAK2の発現解析, 第66回日本口腔外科学会学術集会, Nov. 2021.
34.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, Yukihiro Momota and Masayuki Azuma : シェーグレン症候群新規治療薬としてのJAK阻害薬の可能性, 第75回日本口腔科学会学術集会, May 2021.
35.	石田卓也, Hirokazu Miki, 髙橋真美子, 中村昌史, 水口槙子, Ryohei Sumitani, Masahiro Oura, Kimiko Sogabe, 丸橋朋子, 岡本秀樹, Naoto Okada, 矢野由美子, 高橋真理, Tetsu Tomonari, Takeshi Harada, Shiroh Fujii, Shingen Nakamura, Kumiko Kagawa, Keiko Aota, Hiroyoshi Watanabe and Masahiro Abe : HIV感染血友病患者における臨床的特徴と今後の課題, 第262回徳島医学会学術集会, Mar. 2021.
36.	大山博行, Keiko Aota, 中原崇道, Tomoko Yamanoi, Kohichi Kani, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : Fontan術後患者に対して埋伏智歯抜歯を施行した1例, 第49回日本口腔外科学会中国四国支部学術集会, Feb. 2021.
37.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Shinji Ono, Keiko Aota, Fumihiro Matsumoto, Tomoko Yamanoi, Takamichi Nakahara, 大山博行, Hiroko Kanagawa and Masayuki Azuma : 当科における直接経口抗凝固薬投与下の観血的処置の現状分析, 第30回日本口腔内科学会学術集会, Nov. 2020.
38.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani and Masayuki Azuma : JAK阻害薬バリシチニブは唾液腺細胞のIFN-γ誘導性CXCL10を抑制する, 第65回日本口腔外科学会・学術集会, Nov. 2020.
39.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, Yukihiro Momota and Masayuki Azuma : シェーグレン症候群唾液腺でのMMP-9過剰発現機序とCXCL10への関与, 第74回日本口腔科学会学術集会, Apr. 2020.
40.	Keita Kawarabayashi, Fumiya Kano, Noboru Hashimoto, Jumpei Teramachi, Keiko Aota, Masayuki Azuma, Tsutomu Iwamoto and Akihito Yamamoto : 歯髄幹細胞由来無血清培養上清を用いた口腔乾燥症の治療法の開発, 徳島県歯科医学大会, 20, Feb. 2020.
41.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani and Masayuki Azuma : 唾液腺導管細胞の IFN-γ 誘導性CXCL10 過剰発現における MMP-9 の関与, 第56回日本口腔組織培養学会学術集会, Nov. 2019.
42.	西窪美波, Kohichi Kani, Yukihiro Momota, Keiko Aota, Fumihiro Matsumoto, Tomoko Yamanoi, 中原崇道 and Masayuki Azuma : 上唇に生じた疣贅性黄色腫の1例, 第67回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2019.
43.	中原崇道, Keiko Aota, 西窪美波, Tomoko Yamanoi, Kohichi Kani, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : 舌下神経麻痺とNumb Chin症候群を初発症状としたBurkittリンパ腫の1例, 第67回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2019.
44.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Shinji Ono, Fumihiro Matsumoto, Keiko Aota, 益田奈緒, Tomoko Yamanoi, Hiroko Kanagawa and Masayuki Azuma : 薬物療法が奏効した口腔顔面痛の11例, 第24回日本口腔顔面痛学会, Sep. 2019.
45.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, Naozumi Ishimaru and Masayuki Azuma : シェーグレン症候群の病態形成におけるCXCL10-CXCR3の役割, 第28回日本シェーグレン症候群学会, Sep. 2019.
46.	西窪美波, Kohichi Kani, Yukihiro Momota, Keiko Aota, Fumihiro Matsumoto, Tomoko Yamanoi, 中原崇道 and Masayuki Azuma : Addison病による急性副腎不全を伴った歯性感染症の1例, 第48回日本口腔外科学会中国四国支部学術集会, May 2019.
47.	Tomoko Yamanoi, Keiko Aota, Hideyuki Takano, Kohichi Kani, Yukihiro Momota, Fumihiro Matsumoto, Naozumi Ishimaru and Masayuki Azuma : 舌下-オトガイ下型類皮嚢胞の一例, 第48回日本口腔外科学会中四国支部学術集会, May 2019.
48.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, Naozumi Ishimaru and Masayuki Azuma : シェーグレン症候群の病態形成におけるCXCL10-CXCR3の役割, 第73回日本口腔科学会学術集会, Apr. 2019.
49.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 高瀬奈緒, Tomoko Yamanoi, Shinji Ono, Hiroko Kanagawa and Masayuki Azuma : 当科における直接経口抗凝固薬投与下の観血的処置の現状, 第73回日本口腔科学会学術集会, Apr. 2019.
50.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, 益田奈緒, Hideyuki Takano, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : A case report of tooth extraction in a young patient with cyclic neutropenia, 第63回日本口腔外科学会総会・学術集会, Nov. 2018.
51.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 高瀬奈緒, Hiroko Kanagawa, Tomoko Yamanoi, Yuki Miyamoto and Masayuki Azuma : 漢方薬が奏効した難治性口内炎の6例, 第63回日本口腔外科学会学術大会, Nov. 2018.
52.	Keiko Aota : Establishment of human salivary gland cell lines and their utilization: Elucidation of the pathogenetic mechanism involved in Sjögren's syndrome and its therapeutic effect, 第36回日本ヒト細胞学会学術集会, Aug. 2018.
53.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, Yukihiro Momota and Masayuki Azuma : 唾液腺細胞における CXCL10 発現機構の解析, 第72回日本口腔科学会学術集会, May 2018.
54.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, 高瀬奈緒, Yuki Miyamoto, Shinji Ono and Masayuki Azuma : 一次性舌痛症における唾液アミラーゼ活性測定の有用性, 第72回日本口腔科学会学術集会, May 2018.
55.	Keiko Aota : HIV感染症患者が受診された時の留意点Update, エイズ予防財団委託事業平成29年度HIV医療講習会, Feb. 2018.
56.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani and Masayuki Azuma : セファランチンはヒト唾液腺導管細胞由来IFNγ誘導性CXCL10を抑制する, 第54回日本口腔組織培養学会学術大会, Nov. 2017.
57.	Keiko Aota, 宮本由貴, 高瀬奈緒, Tomoko Yamanoi, Hideyuki Takano, Kohichi Kani, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : 当科における顎骨骨髄炎の臨床統計的検討, 第62回日本口腔外科学会総会・学術総会, Oct. 2017.
58.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, 高瀬奈緒, 宮本由貴, Shinji Ono and Masayuki Azuma : 三剤併用が奏効した一次性舌痛症の3例-口腔領域の難治性疼痛への対応-, 第62回日本口腔外科学会学術大会, Oct. 2017.
59.	高瀬奈緒, Keiko Aota, Yukihiro Momota, Fumihiro Matsumoto, Kohichi Kani, Hideyuki Takano, Tomoko Yamanoi, 宮本由貴, Shinji Ono and Masayuki Azuma : 左側下顎骨筋突起基部から埋伏歯の突出を認めた角化嚢胞性歯原性腫瘍の1例, 第46回日本口腔外科学会中国四国支部学術集会, May 2017.
60.	宮本由貴, Yukihiro Momota, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Hideyuki Takano, 高瀬奈緒, Tomoko Yamanoi, Shinji Ono, 牛尾綾, Naozumi Ishimaru and Masayuki Azuma : 上顎に発生した石灰化を伴わない石灰化上皮性歯原性腫瘍の1例, 第46回日本口腔外科学会中国四国支部学術集会, May 2017.
61.	Hideyuki Takano, Yukihiro Momota, Shinji Ono, 金川裕子, Masami Yoshioka, Fumihiro Matsumoto, Keiko Aota, Kohichi Kani, Tomoko Yamanoi, 高瀬奈緒, 宮本由貴 and Masayuki Azuma : 徳島大学病院緩和ケアセンターにおける口腔機能管理の現況と課題, 第71回日本口腔科学会学術集会, Apr. 2017.
62.	Keiko Aota, 山ノ井朋子, Kohichi Kani, Naozumi Ishimaru and Masayuki Azuma : シェーグレン症候群におけるCXCR3+マクロファージの動態, 第71回日本口腔科学会学術集会, Apr. 2017.
63.	Hideyuki Takano, Yukihiro Momota, Shinji Ono, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 金川裕子 and Masayuki Azuma : 口腔機能管理を行った重症多形滲出性紅斑の2例, 第14回日本口腔ケア学会総会・学術大会, Apr. 2017.
64.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, 山ノ井朋子, 高瀬奈緒, 宮本由貴, Shinji Ono and Masayuki Azuma : ピロカルピン塩酸塩顆粒による有害事象の発現についての検討, 第61回日本口腔外科学会学術大会, Nov. 2016.
65.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, Naozumi Ishimaru and Masayuki Azuma : ヒト唾液腺細胞株における CXCL10 の発現機能解析, 第53回日本口腔組織培養学会学術大会, Nov. 2016.
66.	Kunihiro Ohtsuka, Aya Ushio, 宮本由貴, Satoko Kujiraoka, Akiko Yamada, Keiko Aota, Yasusei Kudo, Masayuki Azuma and Naozumi Ishimaru : 1, 第64回日本口腔科学会中国四国地方部会, Vol.64, Oct. 2016.
67.	宮本由貴, Yukihiro Momota, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Hideyuki Takano, 高瀬奈緒, 山ノ井朋子, Shinji Ono and Masayuki Azuma : 上顎歯肉に発症した骨髄肉腫の1例, 第64回日本口腔科学会中四国地方部会, Oct. 2016.
68.	高瀬奈緒, Yukihiro Momota, Kohichi Kani, 宮本由貴, 山ノ井朋子, Shinji Ono, Hideyuki Takano, Keiko Aota, Fumihiro Matsumoto, 牛尾綾, Naozumi Ishimaru and Masayuki Azuma : 上唇粘膜下に生じた血管筋腫の1例, 第64回日本口腔科学会中四国地方部会, Oct. 2016.
69.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 山ノ井朋子, 高瀬奈緒, 宮本由貴, 小野信二 and Masayuki Azuma : プレガバリン，トラマドール塩酸塩/アセトアミノフェン配合錠および加工附子末製剤の三剤併用が奏効した口腔顔面痛の3例, 第21回日本口腔顔面痛学会, Sep. 2016.
70.	高瀬奈緒, Keiko Aota, 宮本由貴, 山ノ井朋子, Shinji Ono, Hideyuki Takano, Kohichi Kani, Yukihiro Momota, Naozumi Ishimaru and Masayuki Azuma : 口蓋に生じた筋上皮腫の1例, 第45回日本口腔外科学会中四国支部学術集会, May 2016.
71.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, Yukihiro Momota and Masayuki Azuma : 唾液腺細胞における CXCL10 発現機構の解析, 第72回日本口腔科学会学術集会, May 2016.
72.	Kohichi Kani, Yukihiro Momota, Keiko Aota, Hideyuki Takano and Masayuki Azuma : 抜歯後出血に対して動脈塞栓術が奏効した1例, 第45回日本口腔外科学会中国四国支部学術集会, May 2016.
73.	山ノ井朋子, Keiko Aota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Yukihiro Momota, 高瀬奈緒, 宮本由貴, Naozumi Ishimaru and Masayuki Azuma : シェーグレン症候群患者におけるセファランチンの作用機序の解明, 第70回日本口腔科学会学術集会, Apr. 2016.
74.	Keiko Aota, 山ノ井朋子, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, Fumihiro Matsumoto, Naozumi Ishimaru and Masayuki Azuma : Sjögren 症候群唾液腺における IP-10 の発現制御機構, 第70回日本口腔科学会学術集会, Apr. 2016.
75.	Hideyuki Takano, Shinji Ono, Yukihiro Momota, Takaharu Goto, Hideki Suito, 金川裕子, Fumihiro Matsumoto, Keiko Aota, Kohichi Kani and Masayuki Azuma : 徳島大学病院における癌化学療法に対する周術期口腔機能管理の現状と課題, 第13回日本口腔ケア学会総会・学術大会, Apr. 2016.
76.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Keiko Aota, 山ノ井朋子 and Masayuki Azuma : 口腔癌移植ヌードマウスに対するdocrtaxel・γ-tocotrienol併用療法による抗腫瘍効果の検討, 第52回日本口腔組織培養学会学術大会, Nov. 2015.
77.	宮本由貴, Fumihiro Matsumoto, Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Keiko Aota, 高瀬奈緒, 近藤智香, 山ノ井朋子, Shinji Ono and Masayuki Azuma : 糖尿病による顎口腔領域の神経障害性疼痛が疑われた1例, 第63回日本口腔科学会中国・四国地方部会, Vol.0, No.0, 0, Nov. 2015.
78.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 山ノ井朋子, 近藤智香, Shinji Ono, 高瀬奈緒, 宮本由貴, 金川裕子 and Masayuki Azuma : 小児の舌根部に生じた骨性分離腫の1例, 第63回日本口腔科学会中国・四国地方部会, Vol.0, No.0, 0, Nov. 2015.
79.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 山ノ井朋子 and Masayuki Azuma : 一次性舌痛症に関する健康関連QOLの調査-SF-36v2日本語版を用いて-, 第60回日本口腔外科学会学術大会, Oct. 2015.
80.	Keiko Aota : シェーグレン症候群の分子標的治療戦略, 第25回日本口腔内科学会学術大会, Sep. 2015.
81.	Keiko Aota, 山ノ井朋子, 近藤智香, Hideyuki Takano, Daisuke Takegawa, Yoshiko Yamamura, Kohichi Kani, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : 進行期肺がん患者の口腔管理∼ゾレドロン酸，デノスマブ投与前の歯科治療を考える∼, 第12回口腔ケア学会総会, Jun. 2015.
82.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 山ノ井朋子, 金川裕子, Shinji Ono and Masayuki Azuma : 徳島大学病院口腔内科発足前後5年間における外来ならびに入院患者動向について, 第47回四国歯学会例会・第34回四国歯学会総会, Jun. 2015.
83.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Daisuke Takegawa, 山ノ井朋子, 近藤智香 and Masayuki Azuma : 新規口腔ケア製品「ペプチサルシリーズ」の使用感に関する調査, 第12回日本口腔ケア学会, Jun. 2015.
84.	Keiko Aota, 山ノ井朋子, 近藤智香, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : Sjögren 症候群唾液腺における IP-10 の発現機能解析, 第69回日本口腔科学会学術集会, May 2015.
85.	近藤智香, Fumihiro Matsumoto, Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Keiko Aota, 山ノ井朋子 and Masayuki Azuma : 当科における顎関節脱臼症例の臨床的検討, 第44回日本口腔外科学会中国四国支部学術集会, Apr. 2015.
86.	Keiko Aota, Yoshiko Yamamura, 山ノ井朋子, 近藤智香, Daisuke Takegawa, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, 松本文博 and Masayuki Azuma : Sjögren 症候群唾液腺における IP-10 の役割, 第51回日本口腔組織培養学会学術大会, Nov. 2014.
87.	Yoshiko Yamamura, Hiromitsu Takizawa, Fumihiro Matsumoto, Yukihiro Momota, Keiko Aota, Daisuke Takegawa, Kohichi Kani, Hideyuki Takano, 山ノ井朋子, 近藤智香, 金川裕子, 高瀬奈緒, Yuka Sogawa and Masayuki Azuma : 肺癌患者における周術期口腔機能管理の有用性について-術後合併症の観点より-, 第62回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2014.
88.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, 山ノ井朋子, 近藤智香 and Masayuki Azuma : 一次性舌痛症に対する心拍間変異分析-Time-Domain測定の意義-, 第59回日本口腔外科学会学術大会, Oct. 2014.
89.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 山ノ井朋子, 近藤智香 and Masayuki Azuma : 5-FUによるヒト口腔粘膜上皮細胞の増殖抑制とγ-T3によるその解除機構の検討, 第59回日本口腔外科学会学術大会, Oct. 2014.
90.	Keiko Aota, 山ノ井朋子, 近藤智香, Hideyuki Takano, Yukihiro Momota, Kohichi Kani, Fumihiro Matsumoto and Masayuki Azuma : Sjögren症候群におけるサイトカイン/ケモカイン発現の解析, 第59回日本口腔外科学会学術大会, Oct. 2014.
91.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Yoshiko Yamamura, Daisuke Takegawa, 山ノ井朋子, 近藤智香, 金川裕子 and Masayuki Azuma : 徳島大学病院口腔内科組織改編前後の患者動向について, 第24回日本口腔内科学会, Sep. 2014.
92.	Keiko Aota, Yoshiko Yamamura, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, Fumihiro Matsumoto, Fumiaki Kawano, Takashi Matsuo and Masayuki Azuma : 徳島大学病院における周術期口腔機能管理の現状と課題, 第11回日本口腔ケア学会総会・学術大会, Jun. 2014.
93.	Yoshiko Yamamura, Keiko Aota, Yukihiro Momota, Fumihiro Matsumoto, Kohichi Kani, Hideyuki Takano and Masayuki Azuma : 頭頸部領域に対する癌化学放射線療法による口腔粘膜炎の実態調査, 第11回日本口腔ケア学会総会, Jun. 2014.
94.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Yoshiko Yamamura, Daisuke Takegawa, 山ノ井朋子, 近藤智香, 金川裕子 and Masayuki Azuma : 徳島大学病院口腔内科発足前後の患者動向について, 第45回四国歯学会例会・第33回四国歯学会総会, Jun. 2014.
95.	Keiko Aota, Yoshiko Yamamura, Kohichi Kani, Hideyuki Takano, Katsumi Motegi, Fumihiro Matsumoto, Naozumi Ishimaru and Masayuki Azuma : ドライマウス患者における唾液中のTNF-αとMMP-9発現に関する研究, 第68回日本口腔科学会学術集会, May 2014.
96.	Yoshiko Yamamura, Katsumi Motegi, Keiko Aota, Yukihiro Momota and Masayuki Azuma : 唾液腺腺房細胞におけるMAPK経路を介したAQP5発現機構-SMRTとHDAC3発現からの解析-, 第68回日本口腔科学会学術集会, May 2014.
97.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura and Masayuki Azuma : 一次性舌痛症における手掌部発汗の発現-皮膚水分量測定の有用性について-, 第68回日本口腔科学会学術集会, May 2014.
98.	Fumihiro Matsumoto, Yukihiro Momota, Hideyuki Takano, Yoshiko Yamamura, Kohichi Kani, Keiko Aota, Katsumi Motegi and Masayuki Azuma : 顎関節脱臼患者における臨床的検討, 第43回日本口腔外科学会中・四国地方会, Apr. 2014.
99.	山ノ井朋子, Keiko Aota, 近藤智香, Yoshiko Yamamura, Hideyuki Takano, Kohichi Kani, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : 抜歯後出血を契機に診断された後天性von Willebrand症候群の1例, 第43回日本口腔外科学会中四国支部学術集会, Apr. 2014.
100.	Yoshiko Yamamura, Katsumi Motegi, Keiko Aota and Masayuki Azuma : ヒト唾液腺腺房細胞におけるAQP5発現機構 -MAPK経路の関与-, 日本口腔組織培養学会設立50周年記念学術大会, Nov. 2013.
101.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Keiko Aota and Masayuki Azuma : 下顎歯肉に生じた周辺性エナメル上皮腫の1例, 第61回日本口腔科学会中国・四国地方部会, Nov. 2013.
102.	Fumihiro Matsumoto, Yukihiro Momota, Hideyuki Takano, Yoshiko Yamamura, Kohichi Kani and Keiko Aota : 顎関節症と鑑別を要する疾患あるいは障害に関する実態調査 —紹介により顎関節症外来を受診した患者における検討—, 第61回NPO法人日本口腔科学会中国・四国地方部会, Nov. 2013.
103.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Keiko Aota, Yoshiko Yamamura and Masayuki Azuma : ヒト口腔癌移植ヌードマウスに対するdocetaxel・γ-tocotrienol併用による抗腫瘍効果の検討, 第12回中四国口腔癌研究会, Nov. 2013.
104.	Yoshiko Yamamura, Keiko Aota, Fumihiro Matsumoto, Yukihiro Momota, Katsumi Motegi, Kohichi Kani, Hideyuki Takano and Masayuki Azuma : 入院精神疾患患者に対する歯科介入について, 第30回日本障碍者歯科学会学術大会, Oct. 2013.
105.	Keiko Aota, Kohichi Kani, Yoshiko Yamamura, Hideyuki Takano, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : 口腔粘膜に初発した自己免疫性水疱症5例の臨床的検討, 第23回日本口腔内科学会, Sep. 2013.
106.	Yuka Sogawa, Keiko Aota, 石川久子, 田口侑子, 武川香織, 高橋侑子, 薫廣瀬, Hiromi Nagai, Masami Yoshioka, Chieko Sugawara, Yoshiko Yamamura, Hideyuki Takano, Kohichi Kani, Katsumi Motegi, Yukihiro Momota, Fumihiro Matsumoto, Masayuki Azuma and Fumiaki Kawano : 徳島大学病院における周術期口腔機能管理の現状, 第10回日本口腔ケア学会・総会, Jun. 2013.
107.	Yoshiko Yamamura, Yukihiro Momota, Keiko Aota, Hideyuki Takano and Masayuki Azuma : 徳島大学病院腎臓内科との医・歯連携 - 腎疾患治療前からの積極的介入 -, 第10回日本口腔ケア学会学術大会, Jun. 2013.
108.	Yukihiro Momota, 茂木勝美, Keiko Aota, Hideyuki Takano, Kohichi Kani and Masayuki Azuma : ワルファリン療法中に急速に増大・破裂した軟硬口蓋粘膜下血腫の1例, 第67回日本口腔科学会学術集会, May 2013.
109.	Yoshiko Yamamura, Keiko Aota, Hideyuki Takano, Kohichi Kani, Yukihiro Momota and Masayuki Azuma : ヒト唾液腺腺房細胞における恒常的AQP5発現制御機構, 第67回日本口腔科学会学術集会, May 2013.
110.	Keiko Aota, Yoshiko Yamamura, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, Fumihiro Matsumoto, Naozumi Ishimaru and Masayuki Azuma : シェーグレン症候群に対する新規治療戦略―唾液腺腺房構造の破壊を阻止する-, 第67回日本口腔科学会学術集会, May 2013.
111.	Yoshiko Yamamura, Yukihiro Momota, Keiko Aota, Hideyuki Takano, Kohichi Kani and Masayuki Azuma : 徳島大学病院腎臓内科との医・歯連携―腎疾患患者の口腔管理について-, 第42回日本口腔外科学会中国四国支部学術集会, Apr. 2013.
112.	Keiko Aota, Hideyuki Takano, Kohichi Kani, Yoshiko Yamamura and Masayuki Azuma : リツキシマブの投与によって生じた口腔・上部消化管潰瘍の1例, 第57回日本口腔外科学会総会, 2013.
113.	Keiko Aota, Yoshiko Yamamura, Kohichi Kani, Katsumi Motegi, Yukihiro Momota and Masayuki Azuma : 抗TNF製剤のヒト唾液腺腺房細胞に及ぼす影響―抗TNF製剤はシェーグレン症候群の治療薬と成り得るか―, 第49回日本口腔組織培養学会, Nov. 2012.
114.	Keiko Aota, Hideyuki Takano, Kohichi Kani, Yoshiko Yamamura and Masayuki Azuma : リツキシマブ投与半年後に難治性口底潰瘍を生じた原発性マクログロブリン血症の1例, 第57回日本口腔外科学会総会学術大会, Oct. 2012.
115.	Katsumi Motegi, Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Keiko Aota, Yoshiko Yamamura and Masayuki Azuma : 抜歯後の止血困難をきっかけに発見された後天性血友病の1例, 第57回日本口腔外科学会総会学術大会, Oct. 2012.
116.	Yoshiko Yamamura, Keiko Aota, Katsumi Motegi, Yukihiro Momota and Masayuki Azuma : 加齢に伴う唾液腺機能低下に対するDNA脱メチル化剤の有効性, 第57回日本口腔外科学会総会学術大会, Oct. 2012.
117.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura, 山田佑子, 山ノ井朋子, 原田道人 and Masayuki Azuma : ドセタキセルとg-トコトリエノールの併用による舌癌細胞株に対する抗腫瘍効果の検討, 第57回日本口腔外科学会総会学術大会, Oct. 2012.
118.	山田佑子, Keiko Aota, Yukihiro Momota, Fumihiro Matsumoto, Kohichi Kani, 大守真由子, Yoshiko Yamamura, Hideyuki Takano, Katsumi Motegi and Masayuki Azuma : 頬粘膜下に生じた炎症性偽嚢胞の1例, 第60回日本口腔科学会中国四国地方部会, Oct. 2012.
119.	Yoshiko Yamamura, Keiko Aota, Katsumi Motegi, 山ノ井朋子, Kohichi Kani and Masayuki Azuma : 加齢関連メチル化遺伝子AQP5の機能回復と唾液分泌促進作用, 第60回日本口腔科学会中国四国地方部会, Oct. 2012.
120.	Yoshiko Yamamura, Keiko Aota, 大守真由子, Fumihiro Matsumoto and Masayuki Azuma : 精神疾患患者の歯科介入の重要性についての検討, 第29回日本障害者歯科学会学術大会, Sep. 2012.
121.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, 原田道人, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura, 花木秀明 and Masayuki Azuma : カンジダ検出イムノクロマトを用いた口腔カンジダ迅速検査法の有用性, 第25回日本口腔診断学会, Sep. 2012.
122.	Keiko Aota, Katsumi Motegi, Yoshiko Yamamura, Hideyuki Takano and Masayuki Azuma : シェーグレン症候群患者におけるセファランチンの唾液分泌促進効果, 第21回シェーグレン症候群学会学術集会, Sep. 2012.
123.	Keiko Aota, Yoshiko Yamamura, 大守真由子, Yukihiro Momota and Masayuki Azuma : 徳島大学病院精神科神経科入院患者における口腔ケアの有用性について, 第9回日本口腔ケア学会学術総会, Jun. 2012.
124.	Keiko Aota, Yoshiko Yamamura, 大守真由子 and Masayuki Azuma : シェーグレン症候群患者の唾液腺腺房構造破壊阻止ーセファランチンの有効性に関する臨床病理学的研究ー, 第66回日本口腔科学会学術集会, May 2012.
125.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura, 大守真由子 and Masayuki Azuma : 舌癌細胞株に対するドセタキセルの抗腫瘍効果に及ぼすg-tocotrienolの影響, 第66回日本口腔科学会学術集会, May 2012.
126.	Keiko Aota, Katsumi Motegi, Yukihiro Momota, Naozumi Ishimaru and Masayuki Azuma : シェーグレン症候群患者の唾液腺腺房構造破壊阻止―セファランチンの有効性に関する臨床病理学的研究―, 第66回日本口腔科学会学術総会, May 2012.
127.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, Keiko Aota, 大守真由子, Fumihiro Matsumoto, Katsumi Motegi, Yoshiko Yamamura, Fumiaki Kawano and Masayuki Azuma : 徳島大学病院ICUにおける口腔ケアで遭遇する舌褥瘡性潰瘍に対する試み, 第41回(社)日本口腔外科学会中・四国地方会, Apr. 2012.
128.	Yoshiko Yamamura, Yukihiro Momota, Hideyuki Takano, Keiko Aota, 大守真由子 and Masayuki Azuma : 医科疾患を有する患者の治療前歯科口腔ケア介入について, 第41回日本口腔外科学会中四国地方会, Apr. 2012.
129.	Keiko Aota, Yoshiko Yamamura, 大守真由子 and Masayuki Azuma : 徳島大学病院精神科神経科患者に対する歯科治療に関する検討, 第21回(社)日本有病者歯科医療学会学術総会, Mar. 2012.
130.	Yoshiko Yamamura, Katsumi Motegi, 山ノ井朋子, Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Keiko Aota and Masayuki Azuma : 加齢マウスにおける唾液分泌/AQP5発現低下に対するDNA脱メチル化剤の有効性の検討, 第59回日本口腔科学会中国四国地方部会, Nov. 2011.
131.	Yoshiko Yamamura, Katsumi Motegi, Keiko Aota, Yukihiro Momota and Masayuki Azuma : TNF-αによる唾液腺腺房細胞でのヒストンH4アセチル化を介したAQP5発現抑制, 第48回日本口腔組織培養学会学術大会, Nov. 2011.
132.	Yoshiko Yamamura, Katsumi Motegi, Yukihiro Momota, Keiko Aota, Kohichi Kani, Hideyuki Takano and Masayuki Azuma : 唾液腺線房細胞におけるTNF-αによるAQP5発現抑制機構, 第56回日本口腔外科学会総会, Oct. 2011.
133.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura and Masayuki Azuma : 当科を受診した舌痛症患者の臨床統計学的検討 ―自律神経系の関与について―, 第56回日本口腔外科学会総会学術大会, Oct. 2011.
134.	Keiko Aota, 松本憲, Yoshiaki Yura and Masayuki Azuma : 10歳女児に発症した開花性骨異型性の長期治療経過, 第40回(社)日本口腔外科学会中・四国地方会, May 2011.

Et cetera, Workshop:

1.	Kohei Naniwa, 金川裕子, Shinji Ono, 西田真理, 大山博行, Mami Sato-Fukuba, Kohichi Kani, Yukihiro Momota, Hideyuki Takano and Keiko Aota : 整形外科インプラント手術における周術期口腔機能管理の有効性の検討, 四国歯学会第63回例会, Mar. 2024.
2.	Keiko Aota : 中国・四国ブロックのエイズ対策について∼歯科の現状∼, 令和3年度第2回中国・四国ブロックエイズ治療拠点病院等連絡協議会, Jan. 2022. (Keyword) エイズ対策 / community dental health
3.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 高瀬奈緒, Tomoko Yamanoi, Shinji Ono, Hiroko Kanagawa and Masayuki Azuma : 葛根湯が奏効した特発性first bite syndromeの1例-心拍間変異分析と健康関連QOLの評価について-, 徳島大学歯学部口腔内科同門会誌, Vol.35, 8-12, Dec. 2020.
4.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, 高瀬奈緒, Tomoko Yamanoi, Shinji Ono, Hiroko Kanagawa and Masayuki Azuma : 当科における直接経口抗凝固薬投与下の観血的処置の現状, 徳島大学歯学部口腔内科同門会誌, Vol.34, 8-12, Dec. 2019.
5.	Keiko Aota : 周術期口腔機能管理骨転移治療薬投与前の歯科治療を考える, 四国歯学会第50回例会, Mar. 2017.
6.	Keiko Aota : HIV感染者の歯科医療―徳島大学病院における現状―, 平成28年度HIV医療講習会, Feb. 2017.
7.	Keiko Aota : HIV歯科診療体制の活動状況について―徳島県―, 第7回中国四国地方 HIV 陽性者の歯科診療体制構築のための研究会議, Nov. 2016.
8.	Keiko Aota : 徳島大学病院の周術期口腔機能管理の現状と課題, 日本口腔看護研究会第4回徳島地区セミナー, Aug. 2016.
9.	Keiko Aota : HIV感染症と歯科医療, 平成27年度HIV医療講習会, Mar. 2016.
10.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Keiko Aota, 山ノ井朋子, 高瀬奈緒, 宮本由貴, Shinji Ono and Masayuki Azuma : ピロカルピン塩酸塩顆粒による有害事象の発現についての検討, 徳島大学歯学部口腔内科同門会誌,, Vol.31, 10-11, 2016.
11.	Keiko Aota : HIV感染症と歯科医療-徳島大学病院における現状-, 平成26年度HIV医療講習会(エイズ予防財団委託事業), Feb. 2015.
12.	Junichiro Satomi, Yoshiko Yamamura, Keiko Aota, Daisuke Takegawa, Fumihiro Matsumoto, Yuka Sogawa and Masayuki Azuma : 徳島大学病院脳卒中センターにおける口腔管理の意義について, 第17回徳島脳卒中研究会, Feb. 2015.
13.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Keiko Aota, Fumihiro Matsumoto, Yoshiko Yamamura, Daisuke Takegawa, 山ノ井朋子, 近藤智香, 金川裕子 and Masayuki Azuma : がん治療における周術期口腔機能管理の現状と課題, 徳島大学病院Cancer Board, Sep. 2014.
14.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Keiko Aota and Masayuki Azuma : 下顎歯肉に生じた周辺性エナメル上皮腫の1例, 徳島大学歯学部口腔内科同門会誌, Vol.28, 13-14, 2013.
15.	Keiko Aota, Yoshiko Yamamura, Katsumi Motegi, Naozumi Ishimaru and Masayuki Azuma : シェーグレン症候群患者に対するセファランチンの有効性に関する臨床病理学的研究, Shikoku Dental Research, Mar. 2012.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Novel pathogenesis and therapeutic strategy of autoimmunity based on immune-tuning molecules (Project/Area Number: 23H00438 )
免疫細胞フェノタイプによるシェーグレン症候群の個別化医療の構築 (Project/Area Number: 22K10172 )
シェーグレン症候群に対する病期・病態対応型シームレス医療の構築 (Project/Area Number: 20K10119 )
JAK/STATシグナル制御を標的としたシェーグレン症候群の新規治療戦略 (Project/Area Number: 19K10311 )
Development of a novel treatment for Sjogren's syndrome on the basis of the regulation of molecules related to the syndrome (Project/Area Number: 17K11842 )
Development of a new method for diagnostic and treating Sjogren's syndrome by targeting IP-10 (Project/Area Number: 15K11254 )
Salivary gland regeneration by anti-TNF regents (Project/Area Number: 24792226 )
Sensitivity diagnosis of molecular target drugs for oral cancer (Project/Area Number: 21791990 )
Apply to imatinib in oral cancer treatment (Project/Area Number: 19791511 )
Analysis of Wnt signal pathway in the invasion and metastasis of oral squamous carcinoma cells and application to molecule target therapy (Project/Area Number: 19592293 )
Search by Researcher Number (70437391)

Associate Professor : Aota, Keiko

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)