徳島大学 / 教育研究者総覧 --- 髙須千絵

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著書・論文

学術論文(審査論文):

1.	Chie Takasu, Shuhai Chen, Luping Gao, Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada and Mitsuo Shimada : Role of Nrf2 signaling in development of hepatocyte-like cells, The Journal of Medical Investigation : JMI, Vol.70, No.3,4, 343-349, 2023. (要約) Generation of hepatocytes from human adipose-derived mesenchymal stem cells (hADSCs) could be a promising alternative source of human hepatocytes. However, mechanisms to differentiate hepatocytes from hADSCs are not fully elucidated. We have previously demonstrated that our three-step differentiation protocol with glycogen synthase kinase (GSK) 3 inhibitor was effective to improve hepatocyte functions. In this study, we investigated the activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) on hADSCs undergoing differentiation to HLC (hepatocyte-like cells). Our three-step differentiation protocol was applied for 21 days (Step 1:day 1-6, Step2:day 6-11, Step3:day 11-21). Our results show that significant nuclear translocation of Nrf2 occurred from day 11 until the end of HLC differentiation. Nuclear translocation of Nrf2 and CYP3A4 activity in the GSK3 inhibitor-treated group was obviously higher than that in Activin A-treated groups at day 11. The maturation of HLCs was delayed in Nrf2-siRNA group compared to control group. Furthermore, CYP3A4 activity in Nrf2-siRNA group was decreased at the almost same level in Activin A-treated group. Nrf2 translocation might enhance the function of HLC and be a target for developing highly functional HLC. J. Med. Invest. 70 : 343-349, August, 2023. (キーワード) Humans / NF-E2-Related Factor 2 / Glycogen Synthase Kinase 3 / Cytochrome P-450 CYP3A / Hepatocytes / Cell Differentiation / RNA, Small Interfering (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.343 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940517 ● Search Scopus @ Elsevier (PMID): 37940517 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.343 (DOI: 10.2152/jmi.70.343, PubMed: 37940517)
2.	Shoko Yamashita, Chie Takasu, Yuji Morine, Hiroki Ishibashi, Tetsuya Ikemoto, Hiroki Mori, Shin-ichiro Yamada, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada : Characteristic submucosal alteration in biliary carcinogenesis of pancreaticobiliary maljunction with a focus on inflammasome activation., Journal of Hepato-Biliary-Pancreatic Sciences, Vol.30, No.4, 462-472, 2023. (要約) Compared with the control and cholecystitis groups, αSMA expression was higher in the cancerous part (stroma) of the GB in patients with GB cancer + PBM and in the lamina propria of patients with PBM. The CD204/CD68 ratio in the lamina propria was higher in the PBM group than in the control and cholecystitis groups. NLRP3 and caspase 1 expression in both the lamina propria and epithelium was higher in the PBM than control group. In the PBM group, NLRP3- and caspase 1-positive cells in the lamina propria were located near the epithelium. (キーワード) Humans / Inflammasomes / Bile Ducts / Caspase 1 / NLR Family, Pyrin Domain-Containing 3 Protein / Pancreaticobiliary Maljunction / Pancreatic Ducts / Biliary Tract Neoplasms / Gallbladder Neoplasms / Cholecystitis / Carcinogenesis (徳島大学機関リポジトリ) ● Metadata: 119056 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jhbp.1253 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36259178 ● Search Scopus @ Elsevier (PMID): 36259178 ● Search Scopus @ Elsevier (DOI): 10.1002/jhbp.1253 (徳島大学機関リポジトリ: 119056, DOI: 10.1002/jhbp.1253, PubMed: 36259178)
3.	沖川昌平, 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : Effect of duodenal-jejunal bypass on diabetes in the early postoperative period, Scientific Reports, Vol.13, No.1, 1856-1856, 2023年. (要約) <jats:title>Abstract</jats:title><jats:p>Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results may show that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression.</jats:p> (キーワード) Multidisciplinary (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-023-28923-3 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1360580230617360512 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-28923-3 (DOI: 10.1038/s41598-023-28923-3, CiNii: 1360580230617360512)
4.	Shohei Okikawa, Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto : Effect of duodenal-jejunal bypass on diabetes in the early postoperative period., Scientific Reports, Vol.13, No.1, 1856, 2023. (要約) Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results may show that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression. (キーワード) Rats / Animals / Jejunum / Diabetes Mellitus, Type 2 / Positron Emission Tomography Computed Tomography / Fluorodeoxyglucose F18 / Duodenum / Glucose / Glucose Transport Proteins, Facilitative / Blood Glucose / Gastric Bypass (徳島大学機関リポジトリ) ● Metadata: 118744 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-023-28923-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36726038 ● Search Scopus @ Elsevier (PMID): 36726038 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-28923-3 (徳島大学機関リポジトリ: 118744, DOI: 10.1038/s41598-023-28923-3, PubMed: 36726038)
5.	Yosuke Iwakawa, Kouzou Yoshikawa, Koichi Okamoto, Tetsuji Takayama, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto, Shoko Yamashita and Mitsuo Shimada : Four cases of gastric adenocarcinoma and proximal polyposis of the stomach treated by robotic total gastrectomy, Surgical Case Reports, Vol.8, No.1, 70, 2022. (要約) Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is a rare disease and characterized by a unique point mutation in the promoter 1B region of the adenomatous polyposis coli (APC) gene. There are two aims in surgery for GAPPS; the first is prophylactic gastrectomy, and the second is excising concurrent cancer. We performed robotic total gastrectomy (RTG) for four cases of GAPPS. Case 1 was a woman in her 40 s whose sister had died from gastric cancer. Mutational analysis revealed mutation of APC exon 1B. We performed prophylactic gastrectomy. Case 2 was a woman in her 30 s who had a mutation of APC exon 1B, and preoperative biopsy revealed suspected adenocarcinoma. Case 3 was a woman in her 40 s who was diagnosed with gastric cancer with multiple polyps in the stomach and a mutation of APC exon 1B. Case 4 was a woman in her 20 s in whom biopsy revealed low-grade dysplasia of a raised lesion. She had a mutation in APC exon 1B. We performed RTG with D1 + lymphadenectomy in all patients, and there were no intraoperative complications. Patients with GAPPS are mainly followed regularly with repeat biopsy, and tumors are detected in an early stage. As the safety of robotic surgery for the early gastric cancer is reported, RTG is an option for these patients. This is the first report of RTG for GAPPS patients. (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s40792-022-01425-6 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35435526 ● Search Scopus @ Elsevier (PMID): 35435526 ● Search Scopus @ Elsevier (DOI): 10.1186/s40792-022-01425-6 (DOI: 10.1186/s40792-022-01425-6, PubMed: 35435526)
6.	Shoko Yamashita, Masaaki Nishi, Kozo Yoshikawa, Toshihiro Nakao, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Yuma Wada, Toshiaki Yoshimoto, Yosuke Iwakawa, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada : Gastric carcinoma with lymphoid stroma derived from hamartomatous inverted polyp with osteoclast-like giant cells: a case report., International Cancer Conference Journal, Vol.11, No.3, 196-200, 2022. (要約) Gastric carcinomas with lymphoid stroma (GCLS) are characterized by prominent stromal infiltration of lymphocyte and account for 1-4% of gastric cancers. Although, osteoclast-like giant cells (OGC) have been reported in some GCLS, OGCs in gastric tumors is exceedingly rare. A 60-year-old woman presented to our hospital after the finding of a positive fecal blood test during a routine medical check. Esophagogastroduodenoscopy revealed a Type 0-III + IIc tumor in the middle part of the gastric body. Biopsy revealed a poorly differentiated tumor and she was referred to our department. Early phase computed tomography showed thickening of the wall in the middle of the gastric body and enlargement of nearby lymph nodes. Laparoscopic total gastrectomy was performed. Pathological examination revealed a hamartomatous inverted polyp (HIP) in the submucosal layer with tub2-por1 tumor in the HIP. Prominent lymphocytic infiltration and OGCs were found around the tumor. Immunohistochemical analysis showed that the tumor cells were negative for EBER, MLH-1, and MSH2, 6. These findings suggest that this tumor was a non-microsatellite instability (MSI)-high GCLS without Epstein-Barr virus (EBV) infection. The patient's postoperative course was uneventful and she was discharged 11 days after surgery. She remains well 3 years after surgery. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s13691-022-00547-w (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35669900 ● Search Scopus @ Elsevier (PMID): 35669900 ● Search Scopus @ Elsevier (DOI): 10.1007/s13691-022-00547-w (DOI: 10.1007/s13691-022-00547-w, PubMed: 35669900)
7.	Masaaki Nishi, Ryosuke Miyamoto, Kasane Shima, Hirokazu Miki, Hideo Terasawa, Chie Takasu, Kouzou Yoshikawa, Takuro Oyama, Katsuya Tanaka, Yuishin Izumi and Mitsuo Shimada : Robot-assisted total gastrectomy for gastric cancer in a patient with amyotrophic lateral sclerosis receiving long-term tracheostomy invasive ventilation, International Cancer Conference Journal, Vol.10, No.4, 318-323, 2021. (要約) Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Although affected patients may develop cancers, major surgical intervention has been hampered by its questionable overall benefit due to limited prognosis and risk of postoperative respiratory collapse. A recent study, however, showed that tracheostomy invasive ventilation (TIV) prolonged median survival to 11.3 years; thus, patients with ALS receiving TIV might benefit from major surgery. A 66-year-old man with ALS, who had received TIV and enteral tube feeding for 8 years, presented with bloody stool. The patient also had type 2 diabetes mellitus, stage 4 chronic kidney disease, abdominal aortic aneurysm, and anti-phospholipid syndrome, as well as multiple episodes of pneumonia and catheter-related urinary tract infection treated by antibiotics. Medical examination and esophagogastroduodenoscopy revealed a type 3 tumor in the middle part of the stomach. The patient's preoperative diagnosis was gastric cancer (GC), MU, type3, Less-Post, T3(SS), N1, H0, P0, M0, cStage III. The estimated mortality rate was 30.5%, according to the Japanese National Clinical Database. The patient and his family were fully informed of the risk of surgery; the patient clearly requested curative surgery by eye movement. Thus, robot-assisted total gastrectomy (RATG) was performed. The tissues were extremely fragile and hemorrhagic. The surgical time was 7 h 0 min; intraoperative blood loss was 324 ml. Pathological examination revealed GC, MU, type3, T4a(SE), N2, H0, CY0, P0, M0 fStage IIIB. The postoperative course was uneventful. He has remained in stable condition for 3 months. Our findings suggest that patients with ALS who achieve longer survival with TIV can undergo major cancer surgery, including robot-assisted surgery, which may facilitate a better mid-long-term prognosis. The online version contains supplementary material available at 10.1007/s13691-021-00499-7. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s13691-021-00499-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34567945 ● Search Scopus @ Elsevier (PMID): 34567945 ● Search Scopus @ Elsevier (DOI): 10.1007/s13691-021-00499-7 (DOI: 10.1007/s13691-021-00499-7, PubMed: 34567945)
8.	Shoko Yamashita, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Shinichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Katsuki Miyazaki, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada : A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2., World Journal of Surgical Oncology, Vol.19, No.1, 142, 2021. (要約) This method could be used to classify IHCC into peripheral and perihilar type by embryological expression patterns of SSTR2 and Bcl2. (キーワード) Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Cholangiocarcinoma / Humans / Prognosis / Proto-Oncogene Proteins c-bcl-2 / Receptors, Somatostatin (徳島大学機関リポジトリ) ● Metadata: 116986 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12957-021-02216-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33962620 ● Search Scopus @ Elsevier (PMID): 33962620 ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-021-02216-3 (徳島大学機関リポジトリ: 116986, DOI: 10.1186/s12957-021-02216-3, PubMed: 33962620)
9.	Toshiaki Yoshimoto, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yukako Takehara and Mitsuo Shimada : Bevacizumab-associated intestinal perforation and perioperative complications in patients receiving bevacizumab., Annals of Gastroenterological Surgery, Vol.4, No.2, 151-155, 2020. (要約) The purposes of this study are to present cases of emergency surgery in which gastrointestinal perforation occurred during bevacizumab administration, consider the indications for emergency surgery, and examine the safety of scheduled surgery after a washout period for bevacizumab. (a) We retrospectively investigated seven patients who underwent emergency surgery for bevacizumab-associated intestinal perforation. (b) We investigated 104 patients with advanced colorectal cancer treated with neoadjuvant therapy who underwent surgery from 2008 to 2018, retrospectively. (a) In the seven patients undergoing emergency surgery for gastrointestinal perforation, the median bevacizumab administration and washout periods were 16 weeks and 24 days, respectively. A stoma was created in all patients except in those who were not candidates. Two patients developed postoperative abdominal abscesses, and two patients died from perioperative sepsis and gastrointestinal bleeding, respectively; both of these patients had poor performance status. (b) In patients receiving bevacizumab (n = 45) and patients treated with bevacizumab-free regimens as neoadjuvant therapy (n = 59), 31 and 52 patients received chemoradiotherapy, respectively. We found no correlation with postoperative complications with or without bevacizumab. The surgical indications should be considered carefully in patients with gastrointestinal perforation secondary to bevacizumab administration. Meanwhile, after appropriate cessation time, scheduled surgery following bevacizumab administration is feasible. (徳島大学機関リポジトリ) ● Metadata: 116475 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/ags3.12312 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32258980 ● Search Scopus @ Elsevier (PMID): 32258980 ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12312 (徳島大学機関リポジトリ: 116475, DOI: 10.1002/ags3.12312, PubMed: 32258980)
10.	Daichi Ishikawa, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Mitsuo Shimada : Anastomotic recurrence after laparoscopic distal gastrectomy with delta-shaped anastomosis : report of a case., The Journal of Medical Investigation : JMI, Vol.67, No.1.2, 211-213, 2020. (要約) Delta-shaped anastomosis is nowadays an increasingly performed reconstruction method in laparoscopic distal gastrectomy for early gastric cancer. To date, anastomotic recurrence at the delta-shaped anastomotic site has not been reported. Surgery for this disease is more complicated than anastomotic recurrence at the site of conventional Billroth-I anastomosis. A 68-year-old female was referred to our institute with early gastric cancer on the posterior wall of the antrum. She underwent laparoscopic distal gastrectomy with delta-shaped Billroth-I anastomosis. Follow-up gastrofiberscopy 16 months after the operation revealed suspected anastomotic recurrence, and gastric biopsy revealed signet-ring cell carcinoma. Open total gastrectomy with reconstruction with the Roux-en-Y method was performed. At the distal part of the previous anastomosis, an adequate length of the duodenum was dissected from the pancreas. Then, the duodenum was transected 3 cm distal to the anastomosis using a linear stapler. The patient recovered well and was discharged on postoperative day 14. The patient is alive without re-recurrence 3 years postoperatively. We successfully treated a patient with anastomotic recurrence of gastric cancer after delta-shaped anastomosis. Adequate resection of the duodenal stump was performed without any residual tumor or injury to the pancreas. J. Med. Invest. 67 : 211-213, February, 2020. (キーワード) Aged / Anastomosis, Surgical / Female / Gastrectomy / Humans / Laparoscopy / Neoplasm Recurrence, Local / Recurrence / Stomach Neoplasms (徳島大学機関リポジトリ) ● Metadata: 114831 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.211 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32378612 ● Search Scopus @ Elsevier (PMID): 32378612 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.211 (徳島大学機関リポジトリ: 114831, DOI: 10.2152/jmi.67.211, PubMed: 32378612)
11.	Daichi Ishikawa, Kouzou Yoshikawa, Chie Takasu, Hideya Kashihara, Masaaki Nishi, Takuya Tokunaga, Jun Higashijima and Mitsuo Shimada : Expression Level of MicroRNA-449a Predicts the Prognosis of Patients With Gastric Cancer., Anticancer Research, Vol.40, No.1, 239-244, 2020. (要約) In previous studies, we demonstrated the significant role of microRNA-449a (miR-449a) in colorectal cancer with in vivo and clinical samples. The importance of miR-449a in gastric cancer is still to be elucidated. This study examined the impact of miR-449a expression in tumor tissue and serum and investigated its potential as a prognostic marker in gastric cancer. Sixty-six patients with gastric cancer who underwent surgery were included in the study. miR-449a expression in tumor tissue and serum were investigated by real-time polymerase chain reaction analysis. The association of miR-449a expression with clinicopathological factors and patient prognosis were also investigated. miR-449a expression was lower in tumor tissue than non-tumor tissue. miR-449a in tumor tissue negatively correlated with the malignancy of tumor and clinical stage. Increased carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels were seen at significantly higher frequencies in patients with low miR-449a expression. Patients with low miR-449a expression had poorer cancer-specific survival compared to those with high miR-449a expression. The univariate analysis showed that lymphovascular invasion, increased CEA and CA19-9 and a low expression of miR-449a were associated with a poorer 5-year cancer-specific survival. miR-449a expression level in serum correlated to that in tumor tissue and was also associated with tumor malignancy. The miR-449a level in tumor tissue might be useful as a prognostic indicator for patients with gastric cancer and miR-449a in serum appears to reflect its expression in tumor tissue. (キーワード) Aged / Disease-Free Survival / Female / Gene Expression Regulation, Neoplastic / Humans / Male / MicroRNAs / Prognosis / Stomach Neoplasms (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.13945 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31892572 ● Search Scopus @ Elsevier (PMID): 31892572 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.13945 (DOI: 10.21873/anticanres.13945, PubMed: 31892572)
12.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Toshiaki Yoshimoto and Takashi Iwata : Establishment of an evaluation system for non-technical skills in surgery : Surgeon and paramedical staff assessments., The Journal of Medical Investigation : JMI, Vol.67, No.1.2, 83-86, 2020. (要約) Purposes : Non-technical skills contribute to safe and efficient team performance. The aim of this study was to clarify the importance of non-technical skills by a questionnaire and the usefulness of feedback to the operator. Method : A questionnaire was administered to the operator and paramedical staff for 404 operations. Total and individual scores were compared, and the effect of feedback was analyzed by comparison between pre-feedback and post-feedback. Results : The total score of the paramedical staff was 100 [full score] [n = 186], 90-99 [n = 133], and 80-89 [n = 47]. In all cases, the score of the paramedical staff was significantly better than that of the operator. After feedback, the rate of a score less than 80 was significantly decreased. In junior doctor cases with laparoscopy, feedback tended to have a positive effect. Conclusions : Questionnaires completed by both surgeons and paramedical staff are useful for identifying problems with non-technical skills. J. Med. Invest. 67 : 83-86, February, 2020. (キーワード) Allied Health Personnel / Clinical Competence / Communication / Decision Making / Evaluation Studies as Topic / General Surgery / Humans / Leadership / Patient Care Team / Surgeons / Surveys and Questionnaires (徳島大学機関リポジトリ) ● Metadata: 114757 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.83 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32378623 ● Search Scopus @ Elsevier (PMID): 32378623 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.83 (徳島大学機関リポジトリ: 114757, DOI: 10.2152/jmi.67.83, PubMed: 32378623)
13.	Daichi Ishikawa, Chie Takasu, Hideya Kashihara, Masaaki Nishi, Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa, Koji Yasutomo and Mitsuo Shimada : The Significance of MicroRNA-449a and Its Potential Target HDAC1 in Patients With Colorectal Cancer., Anticancer Research, Vol.39, No.6, 2855-2860, 2019. (要約) miR-449a level might be a prognostic indicator for colorectal cancer and miR-449a might regulate HDAC1 expression. (キーワード) Aged / Antigens, Tumor-Associated, Carbohydrate / Colorectal Neoplasms / Female / Gene Expression Regulation, Neoplastic / Histone Deacetylase 1 / Humans / Liver Neoplasms / Male / MicroRNAs / Middle Aged / Neoplasm Invasiveness / Prognosis / Survival Analysis (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.13414 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31177123 ● Search Scopus @ Elsevier (PMID): 31177123 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.13414 (DOI: 10.21873/anticanres.13414, PubMed: 31177123)
14.	Tumenjin Enkhbat, Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Daichi Ishikawa, Masahide Tominaga and Mitsuo Shimada : Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy., Anticancer Research, Vol.38, No.11, 6247-6252, 2018. (要約) Epigallocatechin-3-gallate (EGCG) is a major polyphenolic component of green tea. EGCG plays a potential role in radio-sensitizing cancer cells. The combined effect of EGCG and radiation was investigated in a colorectal cancer cell line, focusing on nuclear factor (erythroid-derived 2)-like 2 (Nrf2) autophagy signalling. HCT-116 cells were treated with 12.5 μM EGCG for different periods of time, 2 Gy radiation, or both. Cell viability was determined with the WST-8 assay. The number of colonies was determined with the colony formation assay. mRNA expression of LC3 and caspase-9 was analyzed with quantitative real-time polymerase chain reaction. Combination treatment with EGCG and radiation significantly decreased the growth of HCT-116 cells. The number of colonies was reduced to 34.2% compared to the control group. Immunofluorescence microscopy images showed that nuclear translocation of Nrf2 was significantly increased when cells were treated with the combination of EGCG and radiation compared to the control and single-treatment groups. Combined treatment with EGCG and radiation significantly induced LC3 and caspase-9 mRNA expression. EGCG increased the sensitivity of colorectal cancer cells to radiation by inhibiting cell proliferation and inducing Nrf2 nuclear translocation and autophagy. (キーワード) Caspase 9 / Catechin / Cell Nucleus / Cell Proliferation / Cell Survival / Colorectal Neoplasms / Gene Expression Regulation, Neoplastic / HCT116 Cells / Humans / Microtubule-Associated Proteins / NF-E2-Related Factor 2 / Protein Transport / Radiation-Sensitizing Agents / Transcriptional Activation (徳島大学機関リポジトリ) ● Metadata: 113340 (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.12980 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30396944 ● Summary page in Scopus @ Elsevier: 2-s2.0-85056084372 (徳島大学機関リポジトリ: 113340, DOI: 10.21873/anticanres.12980, PubMed: 30396944, Elsevier: Scopus)
15.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi and Chie Takasu : The Effect of Roux-en-Y Reconstruction on Type 2 Diabetes in the Early Postoperative Period., Anticancer Research, Vol.38, No.8, 4901-4905, 2018. (要約) The aim of this study was to investigate the effect of Roux-en-Y (RY) reconstruction on type 2 diabetes with gastric cancer in the early postoperative period. A total of 44 patients with gastric cancer with type 2 diabetes who underwent total gastrectomy (TG) or distal gastrectomy (DG) with Roux-en-Y reconstruction or DG with Bilroth I were enrolled. All three groups had their fasting glucose and daily insulin dose recorded preoperatively, on day 2 postoperatively (POD2) and at discharge. The TG group showed low fasting glucose and daily insulin dose on POD2 compared to their preoperative state. On discharge, the fasting glucose and daily insulin dose were significantly lower in both TG and DG Roux-en-Y groups than preoperatively. Roux-en-Y reconstruction showed early improvement of type 2 diabetes regardless of any body weight loss. The effect of Roux-en-Y reconstruction in TG on type 2 diabetes was more remarkable than that of DG. (キーワード) Aged / Aged, 80 and over / Anastomosis, Roux-en-Y / Blood Glucose / Diabetes Mellitus, Type 2 / Female / Gastrectomy / Gastroenterostomy / Humans / Insulin / Male / Middle Aged / Postoperative Period / Stomach Neoplasms / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.12805 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30061267 ● Search Scopus @ Elsevier (PMID): 30061267 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.12805 (DOI: 10.21873/anticanres.12805, PubMed: 30061267)
16.	Youichiro Kawashita, Yuji Morine, Yu Saitou, Chie Takasu, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, Masato Yoshikawa, Satoru Imura, Toshiyuki Yagi and Mitsuo Shimada : Role of heat shock factor 1 expression in the microenvironment of intrahepatic cholangiocarcinomas., Journal of Gastroenterology and Hepatology, Vol.33, No.7, 1407-1412, 2018. (要約) Heat shock factor 1 (HSF1), a master regulator of heat shock response, has been shown to play a multifaceted role in cancer progression. However, the clinical significance and biological effect of HSF1 expression in intrahepatic cholangiocarcinoma (IHCC) remain unknown. Forty-nine patients with IHCC who underwent hepatic resection were enrolled in this study. HSF1 expression in tumor tissue was determined by immunohistochemistry, and patients were divided into two groups, those with high (n = 20) and low (n = 29) HSF1 expression. Clinicopathological factors including prognosis were compared in these two groups. HSF1 expression was significantly higher in tumors than in normal tissue. The overall survival rate was significantly lower in patients with high than low HSF1. Multivariate analysis showed that high HSF1 expression was a factor independently prognostic of patient survival. High HSF1 expression in tumor tissues may be a prognostic biomarker in patients with IHCC. (キーワード) Adult / Aged / Aged, 80 and over / Bile Duct Neoplasms / Cell Line, Tumor / Cholangiocarcinoma / Disease Progression / Female / Gene Expression / Heat Shock Transcription Factors / Humans / Immunohistochemistry / Male / Middle Aged / Multivariate Analysis / Prognosis / Survival Rate / Tumor Microenvironment (出版サイトへのリンク) ● Publication site (DOI): 10.1111/jgh.14078 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29278438 ● Summary page in Scopus @ Elsevier: 2-s2.0-85043330492 (DOI: 10.1111/jgh.14078, PubMed: 29278438, Elsevier: Scopus)
17.	Tumenjin Enkhbat, Masaaki Nishi, Chie Takasu, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Hideya Kashihara, Daichi Ishikawa and Mitsuo Shimada : Programmed Cell Death Ligand 1 Expression Is an Independent Prognostic Factor in Colorectal Cancer., Anticancer Research, Vol.38, No.6, 3367-3373, 2018. (要約) Programmed cell death protein 1 (PD-1)/ programmed cell death ligand 1(PD-L1) axis is associated with immune tolerance via inhibition of T cell activation. The aim of this study was to clarify the significance of PD-1 and PD-L1 expressions and analyze the relationships between PD-1, PD-L1, transforming growth factor-β (TGF-β) and Forkhead box P3 (Foxp3) expressions in colorectal cancer (CRC). A total of 116 patients who underwent curative colectomy for stage II/III CRC were included in the study. PD-1, PD-L1, TGF-β, and Foxp3 expressions were examined by immunohistochemistry and related to prognostic factors by Kaplan-Meier. PD-1 expression was correlated with PD-L1, TGF-β, and Foxp3 expressions. Overall survival rates were significantly poorer in the PD-1 and PD-L1-positive groups. Multivariate analysis showed that PD-L1-positive is an independent risk factor. Disease-free survival (DFS) was tended in the PD-L1-positive group. The group with double-positive expression had significantly poorer prognosis. PD-1 and PD-L1 expressions were associated with a poor prognosis and correlated with TGF-β and Foxp3 expressions in patients with CRC. (キーワード) Adult / Aged / Aged, 80 and over / B7-H1 Antigen / Colectomy / Colorectal Neoplasms / Female / Forkhead Transcription Factors / Humans / Immunohistochemistry / Kaplan-Meier Estimate / Male / Middle Aged / Prognosis / Programmed Cell Death 1 Receptor / Transforming Growth Factor beta (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.12603 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29848685 ● Summary page in Scopus @ Elsevier: 2-s2.0-85048247787 (DOI: 10.21873/anticanres.12603, PubMed: 29848685, Elsevier: Scopus)
18.	Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Daichi Ishikawa, Yuma Wada and Mitsuo Shimada : The Impact of Indoleamine 2,3-dioxygenase (IDO) Expression on Stage III Gastric Cancer., Anticancer Research, Vol.38, No.6, 3387-3392, 2018. (要約) Indoleamine 2,3-dioxygenase (IDO) down-regulates T cell activation, attenuates regulatory T cell (Treg) activation and is related to immune tolerance. The aim of the study was to clarify the significance of IDO expression and analyze the relationships between the expression of IDO, TGF-β, and Foxp3 in gastric cancer (GC). A total of 60 patients who underwent curative gastrectomy for stage III gastric cancer were included in the study. The expression of IDO, TGF-β, and Foxp3 was examined by immunohistochemistry and the relationship of each expression level to several prognostic factors was examined using univariate and multivariate analyses. IDO expression was not positively correlated with any of the factors examined. IDO expression was positively correlated with TGF-β expression (p<0.05), and TGF-β expression was positively correlated with FoxP3 expression (p<0.05). Overall survival (OS) rates were significantly poorer in the IDO-positive group compared to the IDO-negative group (3-year OS, 78.5% vs. 90%, respectively; p<0.05). Multivariate analysis confirmed IDO expression as independent prognostic factors in OS. Disease-free survival (DFS) was significantly poorer in the IDO-positive group compared to the IDO-negative group (3-year DFS, 59.3% vs. 69.3%, respectively; p<0.05). IDO is associated with poor prognosis and immuno-tolerance through attenuation of Treg activation in Stage III GC. (キーワード) Adult / Aged / Aged, 80 and over / Female / Forkhead Transcription Factors / Gastrectomy / Humans / Immunohistochemistry / Indoleamine-Pyrrole 2,3,-Dioxygenase / Kaplan-Meier Estimate / Male / Middle Aged / Multivariate Analysis / Neoplasm Staging / Prognosis / Stomach Neoplasms / T-Lymphocytes, Regulatory / Transforming Growth Factor beta1 (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.12605 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29848687 ● Summary page in Scopus @ Elsevier: 2-s2.0-85048212303 (DOI: 10.21873/anticanres.12605, PubMed: 29848687, Elsevier: Scopus)
19.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara and Daichi Ishikawa : Usefulness of the Transoral Anvil Delivery System for Esophagojejunostomy After Laparoscopic Total Gastrectomy: A Single-institution Comparative Study of Transoral Anvil Delivery System and the Overlap Method., Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, Vol.28, No.2, e40-e43, 2018. (要約) Many reconstruction techniques have been reported after laparoscopic total gastrectomy (LTG), but it is not clear which anastomosis technique is most useful, and no standard methods have been established. This study examined whether LTG using the transoral anvil delivery system (TOADS) is a feasible and safe procedure for gastric cancer. A series of 47 patients underwent the overlap method and 36 underwent the hemi-double-stapling technique with TOADS. Intraoperative and postoperative outcomes were compared between the 2 groups. In the TOADS group, operation time for reconstruction was shorter (16 3 vs. 45 10in, P=0.003), and blood loss was reduced (45 15 vs. 126 13L, P=0.0002). There were no significant differences in intraoperative complications, conversion to open surgery, and intraoperative anastomosis-related complications between the 2 groups. Furthermore, there were no significant differences in the incidence of complications, reoperation, mortality, and postoperative hospital stay. LTG using TOADS for gastric cancer may be a technically feasible surgical procedure with acceptable morbidity. (キーワード) Adult / Aged / Aged, 80 and over / Esophagostomy / Female / Follow-Up Studies / Gastrectomy / Humans / Jejunostomy / Laparoscopy / Male / Middle Aged / Mouth / Natural Orifice Endoscopic Surgery / Operative Time / Postoperative Complications / Reoperation / Retrospective Studies / Stomach Neoplasms / Suture Techniques / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1097/SLE.0000000000000495 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29064880 ● Search Scopus @ Elsevier (PMID): 29064880 ● Search Scopus @ Elsevier (DOI): 10.1097/SLE.0000000000000495 (DOI: 10.1097/SLE.0000000000000495, PubMed: 29064880)
20.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Syohei Eto and Yoshimi Bando : Ki-67 and Survivin as Predictive Factors for Rectal Cancer Treated with Preoperative Chemoradiotherapy., Anticancer Research, Vol.38, No.3, 1735-1739, 2018. (要約) To evaluate the usefulness of Ki-67 index and survivin as predictive prognostic factors for rectal cancer treated with preoperative chemoradiotherapy. The Ki-67 index and survivin expression were examined in patients with stage II/III rectal cancer (n=46) by immunohistochemistry. Patients were divided into a high-group and a low-group for the Ki-67 index, and positive and negative groups for survivin expression. Overall and disease-free survival were compared between the groups, and the correlation between Ki-67 index and survivin expression was assessed. The 5-year disease-free survival rate of the group with high Ki-67 index was significantly lower than that of the group with low Ki-67 index (53% and 88%, p=0.03), as was the 5-year overall survival rate (68% and 100%, p=0.03). Findings for survivin were not significant. Ki-67 index and survivin may be useful biomarkers for rectal cancer with preoperative CRT. (キーワード) Aged / Biomarkers, Tumor / Chemoradiotherapy / Disease-Free Survival / Female / Humans / Immunohistochemistry / Inhibitor of Apoptosis Proteins / Ki-67 Antigen / Middle Aged / Neoplasm Staging / Predictive Value of Tests / Preoperative Period / Prognosis / Rectal Neoplasms / Survivin (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.12409 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29491110 ● Search Scopus @ Elsevier (PMID): 29491110 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.12409 (DOI: 10.21873/anticanres.12409, PubMed: 29491110)
21.	Toshiaki Yoshimoto, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Daichi Ishikawa, Hiroki Teraoku, Yoshimi Bando and Mitsuo Shimada : The Outcome of Sorafenib Therapy on Unresectable Hepatocellular Carcinoma: Experience of Conversion and Salvage Hepatectomy., Anticancer Research, Vol.38, No.1, 501-507, 2018. (要約) We report the outcomes of sorafenib therapy for advanced hepatocellular carcinoma (HCC) in our Department. Thirty-eight patients with unresectable HCC who were administrated sorafenib from 2009 to 2015 were investigated retrospectively. The 1-year overall survival rate was 59.3%. The macroscopic vascular invasion and response rate were independent prognostic factors of survival. Surgical resection after sorafenib achieved long-term survival in two cases. Case 1: A patient with locally unresectable HCC showed significant response induced by sorafenib, which allowed complete surgical resection. This tumor tested positive for FGF4. Case 2: A patient with a history of hepatectomy for HCC had multiple distant metastases. Most lesions were reduced in size after sorafenib therapy and new lesions in the remnant liver and residual lung metastases were resected. The sorafenib-resistant lesions were negative for FGF4. Sorafenib combined with surgical resection is a feasible option in advanced HCC patients, if sorafenib has been effective. (キーワード) Adult / Aged / Aged, 80 and over / Antineoplastic Agents / Carcinoma, Hepatocellular / Combined Modality Therapy / Female / Fibroblast Growth Factor 4 / Hepatectomy / Hepatitis B / Humans / Liver Neoplasms / Male / Middle Aged / Niacinamide / Phenylurea Compounds / Retrospective Studies / Salvage Therapy / Sorafenib / Survival Rate (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.12250 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29277815 ● Summary page in Scopus @ Elsevier: 2-s2.0-85039796842 (DOI: 10.21873/anticanres.12250, PubMed: 29277815, Elsevier: Scopus)
22.	Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Ichio Suzuka, Takashi Nishizaki, Hiroshi Okitsu, Toshiyuki Yagi, Hidenori Miyake, Murato Miura, Mitsutoshi Fukuyama, Daisuke Wada and Yoshiaki Bando : Propensity score-matched study of laparoscopic and open surgery for colorectal cancer in rural hospitals., Journal of Gastroenterology and Hepatology, Vol.31, No.10, 1700-1704, 2016. (要約) Various randomized clinical studies have suggested that short- and long-term outcomes of laparoscopic surgery (LAP) for colorectal cancer are comparable with those of open surgery (OP). However, these studies were performed in high-volume hospitals. The aim of the present study was to compare the outcomes of LAP versus OP for colorectal cancer in rural hospitals. This was a multicenter retrospective propensity score-matched case-control study of patients who underwent colorectal surgery from January 2004 to April 2009 in 10 hospitals in Japan. All patients underwent curative surgery for pathologically diagnosed stage II or III colorectal cancer. The primary end point was 5-year overall survival (OS). The secondary end points were disease-free survival (DFS) and postoperative complications. In total, 319 patients who underwent LAP and 1020 patients who underwent OP were balanced to 261 pairs. There was no significant difference in the OS and DFS between two groups. The operation time was significantly shorter for OP than for LAP. Blood loss was significantly lower in LAP than in OP. There was no difference in intraoperative morbidity between the two groups. The postoperative morbidity was significantly lower in LAP than in OP. The hospital stay was significantly shorter in LAP than in OP. There was no significant difference in 90-day postoperative mortality. Laparoscopic surgery may be a feasible option for colorectal cancer in rural hospitals. (キーワード) Adult / Aged / Aged, 80 and over / Colectomy / Colorectal Neoplasms / Feasibility Studies / Female / Hospitals, Rural / Humans / Laparoscopy / Length of Stay / Male / Middle Aged / Neoplasm Grading / Neoplasm Staging / Propensity Score / Retrospective Studies / Survival Analysis / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1111/jgh.13322 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26896303 ● Summary page in Scopus @ Elsevier: 2-s2.0-85002156898 (DOI: 10.1111/jgh.13322, PubMed: 26896303, Elsevier: Scopus)
23.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara and Syohei Eto : Combined liver mobilization and retraction: A novel technique to obtain the optimal surgical field during laparoscopic total gastrectomy., Asian Journal of Endoscopic Surgery, Vol.9, No.2, 111-115, 2016. (要約) During laparoscopic gastrectomy, it is important to establish a good operative field and ensure an adequate working space. The combined liver mobilization and retraction method is used to get a safe and optimal view. We retrospectively analyzed 32 consecutive patients who underwent laparoscopic total gastrectomy for gastric cancer. The patients were divided into two groups: the mobilization (+) group (n = 12) and the mobilization (-) group (n = 20). Hepatic function tests were performed in all patients. Mobilization provided a satisfactory view of the working field, especially the gastroesophageal junction and the angle of His during laparoscopic total gastrectomy, and no complications were observed during liver retraction. On postoperative hepatic function testing, there was no significant difference between the two groups on any day. Combined liver mobilization and retraction may be helpful in laparoscopic total gastrectomy. (キーワード) Adult / Aged / Dissection / Female / Gastrectomy / Humans / Laparoscopy / Liver / Liver Function Tests / Male / Middle Aged / Retrospective Studies / Stomach Neoplasms (出版サイトへのリンク) ● Publication site (DOI): 10.1111/ases.12271 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26679094 ● Summary page in Scopus @ Elsevier: 2-s2.0-85016924826 (DOI: 10.1111/ases.12271, PubMed: 26679094, Elsevier: Scopus)
24.	Toshihiro Nakao, Takashi Iwata, Masanori Hotchi, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi, Chie Takasu, Shohei Eto, Hiroki Teraoku and Mitsuo Shimada : Prediction of response to preoperative chemoradiotherapy and establishment of individualized therapy in advanced rectal cancer., Oncology Reports, Vol.34, No.4, 1961-1967, 2015. (要約) Preoperative chemoradiotherapy (CRT) has become the standard treatment for patients with locally advanced rectal cancer. However, no specific biomarker has been identified to predict a response to preoperative CRT. The aim of the present study was to assess the gene expression patterns of patients with advanced rectal cancer to predict their responses to preoperative CRT. Fifty-nine rectal cancer patients were subjected to preoperative CRT. Patients were randomly assigned to receive CRT with tegafur/gimeracil/oteracil (S-1 group, n=30) or tegafur-uracil (UFT group, n=29). Gene expression changes were studied with cDNA and miRNA microarray. The association between gene expression and response to CRT was evaluated. cDNA microarray showed that 184 genes were significantly differentially expressed between the responders and the non-responders in the S-1 group. Comparatively, 193 genes were significantly differentially expressed in the responders in the UFT group. TBX18 upregulation was common to both groups whereas BTNL8, LOC375010, ADH1B, HRASLS2, LOC284232, GCNT3 and ALDH1A2 were significantly differentially lower in both groups when compared with the non-responders. Using miRNA microarray, we found that 7 and 16 genes were significantly differentially expressed between the responders and non-responders in the S-1 and UFT groups, respectively. miR-223 was significantly higher in the responders in the S-1 group and tended to be higher in the responders in the UFT group. The present study identified several genes likely to be useful for establishing individualized therapies for patients with rectal cancer. (キーワード) 欧文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/or.2015.4196 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26260776 ● Search Scopus @ Elsevier (PMID): 26260776 ● Search Scopus @ Elsevier (DOI): 10.3892/or.2015.4196 (DOI: 10.3892/or.2015.4196, PubMed: 26260776)
25.	髙須千絵, 島田光生 : 外科の立場からのキャリアアップ支援と問題点, 第40回日本外科系連合学会学術集会, 2015年.
26.	Shohei Eto, Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Horohiko Sato and Nobuhiro Kurita : The relationship of CD133, histone deacetylase 1 and thrombospondin-1 in gastric cancer., Anticancer Research, Vol.35, No.4, 2071-2076, 2015. (要約) Gastric cancer is one of the most common types of cancer. Cancer stem cells (CSCs) have been reported to play important roles in multiple cancer types. This study investigated the correlation between cluster of differentiation 133 (CD133), histone deacetylase 1 (HDAC1) and thrombospondin-1 (THBS1) expression in advanced gastric cancer. The study included 65 patients with gastric cancer with recurrence after surgery. Expression of CD133, HDAC1 and THBS1 was examined by immunohistochemistry. Prognostic factors were investigated by multivariate analysis using Cox's proportional hazard model. Clinicopathological variables, including survival, of patients positive for CD133 expression (n=6, 23%), were compared with those without CD133 expression (n=20, 77%). Positive HDAC1 expression and THBS1 expression were observed in 34 (52%) and 17 (26%) patients, respectively. Using univariate analysis, positive expression of CD133 and negative expression of THBS1 predicted significantly worse prognosis. Multivariate analysis revealed CD133-positive and THBS1-negative expression were independent prognostic indicators. CD133 expression and THBS1 expression were prognostic factors, and a negative relationship between HDAC and THBS1 was observed in advanced gastric cancer. These biomarkers may help determine postoperative treatment in patients with gastric cancer. (キーワード) 欧文論文 / Aged / Aged, 80 and over / Antigens, CD / Biomarkers, Tumor / Female / Gene Expression Regulation, Neoplastic / Glycoproteins / Histone Deacetylase 1 / Humans / Kaplan-Meier Estimate / Male / Middle Aged / Neoplasm Recurrence, Local / Neoplastic Stem Cells / Peptides / Prognosis / Stomach Neoplasms / Thrombospondin 1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25862862 ● Search Scopus @ Elsevier (PMID): 25862862 (PubMed: 25862862)
27.	Mami Kanamoto, Satoru Imura, Yuji Morine, Tohru Utsunomiya, Hiroki Mori, Yusuke Arakawa, Chie Takasu and Mitsuo Shimada : Effective use of a vessel-sealing system for laparoscopic unroofing of liver cysts., Asian Journal of Endoscopic Surgery, Vol.8, No.1, 91-94, 2015. (要約) Liver cysts that present with symptoms such as jaundice, abdominal pain, and intra-cystic infection require treatment. In laparoscopic unroofing of liver cysts, appropriate treatment is needed in cases where the cystic walls contain vessels or bile ducts. A vessel-sealing system can seal not only vessels, but also bile ducts. We experienced four cases in which laparoscopic unroofing of liver cysts was performed with a vessel-sealing system. Case 1 was a woman in her 70s who presented at our hospital with abdominal pressure. Abdominal CT showed liver cysts with a maximum diameter of 13 cm. Laparoscopic unroofing was performed with LigaSure Impact. Case 2 was a woman in her 50s with abdominal discomfort. CT showed a cyst 15 cm in diameter situated in the right lobe. We performed SILS using a LigaSure Blunt Tip to unroof the cyst. Case 3 was a man in his 80s with abdominal pain. CT showed a huge cyst 25 cm in diameter in the right lobe. We performed hybrid SILS with a LigaSure Blunt Tip to unroof the cysts. Case 4 was a woman in her 70s with upper abdominal pain. CT showed multiple cysts with a maximum diameter of 15 cm in the bilateral lobes. We performed hybrid SILS to successfully unroof her cysts. None of the cases experienced postoperative complications, such as bleeding or bile leakage, and none experienced recurrence of cysts. A laparoscopic unroofing using a vessel-sealing system can be a minimally invasive and safe treatment for liver cysts. (キーワード) Aged / Aged, 80 and over / Blood Loss, Surgical / Cysts / Equipment Design / Female / Follow-Up Studies / Hepatectomy / Hepatic Artery / Hepatic Veins / Humans / Laparoscopy / Liver Diseases / Male / Middle Aged / Postoperative Hemorrhage / Suture Techniques / 欧文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/ases.12134 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25598064 ● Summary page in Scopus @ Elsevier: 2-s2.0-84944232248 (DOI: 10.1111/ases.12134, PubMed: 25598064, Elsevier: Scopus)
28.	Hideya Kashihara, Mitsuo Shimada, Nobuhiro Kurita, Hirohiko Sato, Kouzou Yoshikawa, Jun Higashijima, Motoya Chikakiyo, Masaaki Nishi and Chie Takasu : Duodenal-jejunal bypass improves diabetes and liver steatosis via enhanced glucagon-like peptide-1 elicited by bile acids., Journal of Gastroenterology and Hepatology, Vol.30, No.2, 308-315, 2015. (要約) Bariatric surgery not only elicits weight loss but also rapidly resolves diabetes. However, the mechanisms remain unclear. The present study investigates how diabetes and liver steatosis are improved after duodenal-jejunal bypass (DJB) compared with a glucagon-like peptide-1 (GLP-1) analog and correlations between bile acids and GLP-1 secretion. We initially determined the effects of bile acids on GLP-1 in vitro and then assigned 12 male 16-week-old Otsuka Long-Evans Tokushima Fatty rats to groups that underwent DJB, a sham operation, or were treated with the GLP-1 receptor agonist, liraglutide (n = 4 each). Blood glucose, insulin, GLP-1, serum bile acids, liver steatosis, and the number of GLP-1 positive cells (L cells) in the small intestine and colon were investigated in the three groups at eight weeks postoperatively. Levels of GLP-1mRNA were upregulated and GLP-1 secretion increased in cells incubated with bile acids in vitro. Weight gain was suppressed more in the DJB than in the sham group in vivo. Diabetes was more improved and GLP-1 levels were significantly higher in the DJB than in the sham group. Serum bile acids were significantly increased, the number of L cells in the ileum was upregulated compared with the sham group, and liver steatosis was significantly improved in the DJB compared with the other two groups. Duodenal-jejunal bypass might improve diabetes and liver steatosis by enhancing GLP-1 secretion through increasing serum bile acids and the proliferation of L cells in the ileum, compared with liraglutide. (キーワード) 欧文論文 (徳島大学機関リポジトリ) ● Metadata: 109345 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/jgh.12690 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25088988 ● Search Scopus @ Elsevier (PMID): 25088988 ● Search Scopus @ Elsevier (DOI): 10.1111/jgh.12690 (徳島大学機関リポジトリ: 109345, DOI: 10.1111/jgh.12690, PubMed: 25088988)
29.	髙須千絵, 金本真美, 松本規子, 岩田貴, 吉川幸造, 東島潤, 中尾寿宏, 西正暁, 江藤祥平, 島田光生 : 外科の立場からのキャリアアップ支援, 日本外科系連合学会誌, Vol.40, No.2, 170-173, 2015年. (キーワード) 和文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.4030/jjcs.40.170 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204344302080 ● Search Scopus @ Elsevier (DOI): 10.4030/jjcs.40.170 (DOI: 10.4030/jjcs.40.170, CiNii: 1390001204344302080)
30.	Jun Higashijima, Mitsuo Shimada, Takashi Iwata, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara and Chie Takasu : New ports placement in laparoscopic central lymph nodes dissection with left colic artery preservation for sigmoid colon and rectal cancer., The Journal of Medical Investigation : JMI, Vol.62, No.3-4, 223-227, 2015. (要約) Lymph nodes (LNs) dissection around inferior mesenteric artery (IMA) with left colic artery (LCA) preservation is difficult due to the anatomical feature of IMA. The aim of this study is to evaluate the usefulness of new ports placement inserted from a suprapubic region in laparoscopic LNs dissection around IMA with LCA preservation for sigmoid colon and ractal cancer. Twenty-two patients who underwent laparoscopic colectomy for sigmoid colon and recal cancer were included. The new ports placement group (n=15, new group) was compared with the basic ports placement group (n=7, basic group). Average number of harvested LNs, total operation time, central LNs dissection time, intraoperative blood loss were compared. There was no significant difference in the average number of harvested LNs. The mean of intraoperative blood loss of new group was significantly lower than that of the basic group (40.0±39.8 ml vs 95.7±81.0 ml, p<0.05). In addition, the mean of operation time of the new group was significantly shorter than that of the basic group (250.0±55.7 min vs 353.4±80.2 min, p<0.05). The new ports placement is useful in laparoscopic LNs dissection around IMA with LCA preservation for sigmoid colon and rectal cancer. (キーワード) 欧文論文 (徳島大学機関リポジトリ) ● Metadata: 111283 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.62.223 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26399352 ● Search Scopus @ Elsevier (PMID): 26399352 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.62.223 (徳島大学機関リポジトリ: 111283, DOI: 10.2152/jmi.62.223, PubMed: 26399352)
31.	Chengzhan Zhu, Tohru Utsunomiya, Tetsuya Ikemoto, Shinichiro Yamada, Yuji Morine, Satoru Imura, Yusuke Arakawa, Chie Takasu, Daichi Ishikawa, Issei Imoto and Mitsuo Shimada : Hypomethylation of Long Interspersed Nuclear Element-1 (LINE-1) is Associated with Poor Prognosis via Activation of c-MET in Hepatocellular Carcinoma., Annals of Surgical Oncology, Vol.21, No.4, 729-735, 2014. (要約) LINE-1 was significantly hypomethylated in tumor tissues compared with nontumor tissues (48.3 ± 12.2 % vs. 68.2 ± 2.0 %, respectively, p < 0.0001). LINE-1 hypomethylation was not associated with any clinicopathological factors in HCC patients, except sex (p < 0.05). However, patients with LINE-1 hypomethylation exhibited significantly poorer outcome, and multivariate analysis revealed that LINE-1 hypomethylation was an independent risk factor for overall survival (hazard ratio (HR) = 6.1, p = 0.031) and disease-free survival (HR = 2.34, p = 0.045). L1-MET expression was significantly higher in tumor tissues (p <0.01). L1-MET expression levels were inversely correlated with LINE-1 methylation levels, and positively correlated with c-MET expression (p < 0.05). Furthermore, higher c-MET protein expression was observed in the LINE-1 hypomethylated tumor tissues compared with hypermethylated tumor tissues (p = 0.032). (徳島大学機関リポジトリ) ● Metadata: 109505 (出版サイトへのリンク) ● Publication site (DOI): 10.1245/s10434-014-3874-4 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24992910 ● Summary page in Scopus @ Elsevier: 2-s2.0-84940245895 (徳島大学機関リポジトリ: 109505, DOI: 10.1245/s10434-014-3874-4, PubMed: 24992910, Elsevier: Scopus)
32.	Yu Saitou, Hiroki Mori, Chie Takasu, Masato Komatsu, Jun Hanaoka, Shin-ichiro Yamada, 淺野間理仁, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : Beneficial effects of green tea catechin on massive hepatectomy model in rats., Journal of Gastroenterology, 2013. (要約) BACKGROUND: Green tea catechin, especially epigallocatechin gallate (EGCG), is a well-known scavenger of reactive oxygen species and it may also function as an antioxidant through modulation of transcriptional factors and enzyme activities. METHODS: Green tea extract (GTE(®)) which contained numerous EGCG was used. Wistar rats were performed 90 % hepatectomy and classified into 2 groups with (GTEHx, n = 25) or without GTE treatment (Hx, n = 25) and sacrificed at 1, 3, 7 and 14 days after operations. All rats had free access to drinking water supplemented with or without GTE from the 7th pre-operative day. Liver regeneration, hepatic inducible nitric oxide synthase (iNOS), anti-oxidative enzymes [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px)] and inflammatory markers [cyclooxygenase-2 (COX-2), nuclear factor kappa B (NFκB), tumor necrosis factor-α (TNF-α)] were investigated. RESULTS: The liver weight to body weight ratio (p < 0.01), proliferating cell nuclear antigen labeling index (p < 0.05) and phosphorylated extracellular signal-regulated kinase 1/2 (p < 0.05) at day 1 in the GTEHx group significantly increased compared to the Hx group. Hepatic iNOS levels at day 1 significantly decreased (p < 0.01) in the GTEHx group. Hepatic SOD, CAT and GSH-Px levels at day 1 significantly increased (SOD: p < 0.01, CAT and GSH-Px: p < 0.05) in the GTEHx group. In contrast, COX-2, NFκB and TNF-α levels at day 1 significantly decreased (COX-2: p < 0.01, NFκB and TNF-α: p < 0.05) in the GTEHx group. CONCLUSIONS: GTE pretreatment stimulated liver regeneration and improved liver damage after massive hepatectomy through anti-oxidative and anti-inflammatory effects. Green tea catechin might have the potential to attenuate liver dysfunction in early stage after massive hepatectomy. (キーワード) 欧文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00535-013-0799-9 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23543313 ● Summary page in Scopus @ Elsevier: 2-s2.0-84899985774 (DOI: 10.1007/s00535-013-0799-9, PubMed: 23543313, Elsevier: Scopus)
33.	佐藤宏彦, 島田光生, 栗田信浩, 岩田貴, 西岡将規, 森本慎也, 吉川幸造, 宮谷知彦, 後藤正和, 柏原秀也, 髙須千絵 : 【必読イレウスの診断から治療まで】機械的イレウス複雑性または絞扼性イレウスヘルニア嵌頓, 外科, Vol.74, No.3, 273-278, 2012年.
34.	西岡将規, 島田光生, 栗田信浩, 佐藤宏彦, 岩田貴, 森本慎也, 吉川幸造, 宮谷知彦, 柏原秀也, 髙須千絵 : 癌治療に求められる漢方の意義臨床現場にどのように活かすか"牛車腎気丸"によるFOLFOX関連末梢神経障害の軽減, 産婦人科漢方研究のあゆみ, Vol.29, 22-27, 2012年.
35.	髙須千絵, 島田光生, 吉川幸造, 栗田信浩, 岩田貴, 佐藤宏彦, 西岡将規, 森本慎也, 宮谷知彦, 柏原秀也 : Bevacizumab併用化学療法中に大腸穿孔・穿通をきたした症例の検討, 日本腹部救急医学会雑誌, Vol.32, No.2, 424, 2012年.
36.	Ezar Hafez, Tetsuyuki Takahashi, Tokiko Nakai, Hirohisa Ogawa, Makoto Sato, Chie Takasu, Hisanori Uehara and Keisuke Izumi : High susceptibility to zymbal gland and intestinal carcinogenesis in diabetic Otsuka Long-Evans Tokushima Fatty rats., Journal of Toxicologic Pathology, Vol.24, No.4, 187-193, 2011. (要約) Diabetes mellitus (DM) and obesity are believed to be risk factors for colorectal cancer in humans. In experiment 1, male nondiabetic Long-Evans Tokushima Otsuka (LETO) rats and Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model animal of type 2 DM, were whole-body X-irradiated (4 Gy) at 6 and 8 weeks of age and euthanized at 78 weeks of age (n=15, respectively). The incidences of small intestine adenocarcinoma in LETO and OLETF rats were 0% and 30%, respectively. In experiment 2, male LETO and OLETF rats (n=24, respectively) were given s.c. injections of 15 mg/kg azoxymethane (AOM) once weekly for 3 weeks and euthanized at 36 weeks of age. The incidences of Zymbal gland tumors in LETO and OLETF rats were 0% and 67%, respectively (P<0.001), whereas those of small intestine adenocarcinoma were 0% and 43% (P<0.001) and those of cecum/colon adenocarcinoma were 46% and 79% (P<0.05), respectively. Fatty change of hepatocytes was common in OLETF rats (63%) but not in LETO rats. Serum triglyceride and free fatty acid levels in OLETF rats were significantly higher than in LETO rats at sacrifice, whereas serum insulin levels in OLETF rats were very diverse. These data suggest that hyperlipidemia plays a significant role in high susceptibility to lower intestinal tract carcinogenesis in OLETF rats; this strain is susceptible to AOM-induced Zymbal gland carcinogenesis. (出版サイトへのリンク) ● Publication site (DOI): 10.1293/tox.24.187 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22319230 ● Search Scopus @ Elsevier (PMID): 22319230 ● Search Scopus @ Elsevier (DOI): 10.1293/tox.24.187 (DOI: 10.1293/tox.24.187, PubMed: 22319230)
37.	東島潤, 島田光生, 栗田信浩, 岩田貴, 西岡将規, 森本慎也, 吉川幸造, 宮谷知彦, 柏原秀也, 三上千絵 : 【胃癌術後QOL向上に役立つ手技・再建法とその機能的評価】13Cを用いた空腸吸収能検査・Radioisotope(RI)法による排出能検査からみた胃全摘術後空腸嚢付加Roux-en-Y再建の意義, 癌の臨床, Vol.56, No.5, 377-382, 2011年. (キーワード) Total gastrectomy / Roux-en-Y reconstruction / Jejunal pouch / Radioscintigraphy (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523388080215860608 (CiNii: 1523388080215860608)
38.	岩田貴, 島田光生, 栗田信浩, 西岡将規, 森本慎也, 吉川幸造, 宮谷知彦, 柏原秀也, 髙須千絵 : 【特集】大腸がん鏡視下手術の標準化, 癌の臨床, Vol.56, No.9, 641-648, 2010年. (キーワード) 和文論文 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523669555415783296 (CiNii: 1523669555415783296)

学術論文(紀要・その他):

1.	Chie Takasu, Masaaki Nishi, Kozo Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto and Mitsuo Shimada : Preoperative evaluation to determine the difficulty of No. 6 lymphadenectomy in laparoscopic gastrectomy., BMC Surgery, Vol.24, No.1, 69, 2024. (要約) Laparoscopic gastrectomy (LG) requires a long learning curve because of the complicated surgical procedures. Infrapyloric (No. 6) lymph node dissection (LND) is one of the difficult procedures in LG, especially for trainees. This study investigated the impact of the prediction of the difficulty of No. 6 LND. We retrospectively reviewed the preoperative computed tomography (CT) images and individual operative video records of 57 patients who underwent LG with No. 6 LND to define and predict the No. 6 LND difficulty. To evaluate whether prediction of the difficulty of No. 6 LND could improve surgical outcomes, 48 patients who underwent laparoscopic distal gastrectomy were assessed (30 patients without prediction by a qualified surgeon and 18 patients with prediction by a trainee). The anatomical characteristic that LND required > 2 cm of dissection along the right gastroepiploic vein was defined as difficulty of No. 6 LND. Of the 57 LG patients, difficulty was identified intraoperatively in 21 patients (36.8%). Among the several evaluated anatomical parameters, the length between the right gastroepiploic vein and the right gastroepiploic artery in the maximum intensity projection in contrast-enhanced CT images was significantly correlated with the intraoperative difficulty of No. 6 LND (p < 0.0001). Surgical outcomes, namely intraoperative minor bleeding, postoperative pancreatic fistula, and drain amylase concentration were not significantly different between LG performed by a trainee with prediction compared with that by a specialist without prediction. Preoperative evaluation of the difficulty of No. 6 LND is useful for trainees, to improve surgical outcomes. (キーワード) Humans / Retrospective Studies / Stomach Neoplasms / Lymph Node Excision / Laparoscopy / Gastrectomy / Postoperative Complications (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12893-024-02349-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38389108 ● Search Scopus @ Elsevier (PMID): 38389108 ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-024-02349-8 (DOI: 10.1186/s12893-024-02349-8, PubMed: 38389108)
2.	Chie Takasu, Yuji Morine, Kozo Yoshikawa, Toshihiro Nakao, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto and Mitsuo Shimada : Role of stromal PD-L1 expression in colorectal liver metastasis., BMC Cancer, Vol.24, No.1, 97, 2024. (要約) The outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of immune checkpoint blockade for liver metastasis of various cancer is poor. Here, we investigated the relationship between stromal programmed death-ligand 1 (PD-L1) expression and the prognosis of patients with colorectal cancer liver metastasis (CRLM). The present study enrolled 84 CRLM patients who underwent surgery (R0) for CRC. Immunohistochemistry was performed to analyze stromal PD-L1 expression in CRLM. Stromal PD-L1 was expressed in 52.3% of CRLM samples, which was associated with fewer not optimally resectable metastases (p = 0.04). Stromal PD-L1 also tended to associate with a lower tumor grade (p = 0.08). Stromal PD-L1-positive patients had longer overall survival (p = 0.003). Multivariate analysis identified stromal PD-L1 expression (p = 0.008) and poorer differentiation (p < 0.001) as independent prognostic indicators. Furthermore, stromal PD-L1 expression was correlated to a high number of tumor-infiltrating lymphocytes (TILs). Stromal PD-L1- and low TIL groups had shorter OS than stromal PD-L1 + and high TIL groups (46.6% vs. 81.8%, p = 0.05) Stromal PD-L1-positive patients had longer disease-free survival (DFS) (p = 0.03) and time to surgical failure (p = 0.001). Interestingly, stromal PD-L1 expression was positively related to the desmoplastic subtype (p = 0.0002) and inversely related to the replacement subtype of the histological growth pattern (p = 0.008). Stromal PD-L1 expression may be a significant prognostic marker for CRLM. (キーワード) Humans / B7-H1 Antigen / Colorectal Neoplasms / Immune Checkpoint Inhibitors / Liver Neoplasms / Lymphocytes, Tumor-Infiltrating / Prognosis (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12885-024-11869-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38233811 ● Search Scopus @ Elsevier (PMID): 38233811 ● Search Scopus @ Elsevier (DOI): 10.1186/s12885-024-11869-8 (DOI: 10.1186/s12885-024-11869-8, PubMed: 38233811)
3.	Yuhei Waki, Yuji Morine, Takayuki Noma, Chie Takasu, Hiroki Teraoku, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto and Mitsuo Shimada : Association between high expression of intratumoral fibroblast activation protein and survival in patients with intrahepatic cholangiocarcinoma., BMC Gastroenterology, Vol.23, No.1, 415, 2023. (要約) Cancer-associated fibroblasts (CAFs) have been reported to exhibit protumorigenic effects. Among the well-known CAF markers such as smooth muscle actin (SMA) and fibroblast activation protein (FAP), high expression of SMA in the peritumoral stroma has been reported to be a prognostic factor in various cancers. However, the effect of high FAP expression in intrahepatic cholangiocarcinoma (IHCC) has not been fully clarified. We evaluated the expression of CAF markers, focusing on FAP expression in the peripheral and intratumoral regions, to clarify the association with survival in patients with IHCC. The study cohort comprised 37 patients who underwent curative resection for IHCC. The FAP expressions were evaluated in the peripheral and intratumoral regions of the resected tissues. Clinicopathological factors and survival outcomes were investigated between patients with high versus low FAP expression. Uni- and multivariate analyses were performed to identify the prognostic factors for overall survival and relapse-free survival. The median area percentages of FAP expression in the peripheral and intratumoral regions were 15.5% and 17.8%, respectively. High FAP expression in the intratumoral region was significantly associated with worse overall survival and disease-free survival than low FAP expression in the intratumoral region. Multivariate analysis identified high intratumoral FAP expression as a risk factor for worse overall survival (hazard ratio, 2.450; p = 0.049) and relapse-free survival (hazard ratio, 2.743; p = 0.034). High intratumoral FAP expression was associated with worse survival, suggesting that intratumoral FAP expression represents malignant progression in patients with IHCC. (キーワード) Humans / Neoplasm Recurrence, Local / Cholangiocarcinoma / Cancer-Associated Fibroblasts / Bile Ducts, Intrahepatic / Bile Duct Neoplasms / Prognosis (徳島大学機関リポジトリ) ● Metadata: 119225 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12876-023-03012-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38017374 ● Search Scopus @ Elsevier (PMID): 38017374 ● Search Scopus @ Elsevier (DOI): 10.1186/s12876-023-03012-x (徳島大学機関リポジトリ: 119225, DOI: 10.1186/s12876-023-03012-x, PubMed: 38017374)
4.	Takayuki Noma, Masaaki Nishi, Chie Takasu, Yuuma Wada, Kozo Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto, Yuko Miyakami, Kengo Atsumi, Hisanori Uehara and Mitsuo Shimada : Conversion surgery after successful response to chemotherapy (S-1 + oxaliplatin + nivolumab) in a patient with stage IV gastric cancer with peritoneal metastasis (P1, CY1): a case report., International Cancer Conference Journal, Vol.13, No.1, 11-16, 2023. (要約) We here present a case report of a patient with Stage IV gastric cancer with peritoneal metastasis (P1, CY1) who underwent conversion surgery after a successful response to chemotherapy (S-1 + oxaliplatin + nivolumab). The patient was a woman in her 60 s. Her chief complaint was epigastric pain. Upper gastrointestinal endoscopy showed Type 4 advanced carcinoma on the lesser curvature of the gastric body. Biopsy showed Group 5 (poorly differentiated adenocarcinoma) and HER2 was negative. Staging laparoscopy revealed seeding in the round ligament of the liver (P1) and adenocarcinoma cells in ascites (CY1). Ten courses of chemotherapy (S-1 + oxaliplatin + nivolumab) were administered, after which contrast-enhanced computed tomography showed that the primary tumor had shrunk and seeding was no longer detectable. Upper gastrointestinal endoscopy revealed scar-like changes. A second staging laparoscopy revealed that ascites cytology was negative and a biopsy of the round ligament of the liver showed no malignant cells (P0, CY0). Conversion surgery comprising laparoscopic total gastrectomy with D2 lymph node dissection and resection of the round ligament of the liver was performed. The postoperative course was uneventful. Histopathological examination of the resected specimen revealed no tumor cells in the gastric mesentery or the round ligament of the liver. The pathological diagnosis was gastric cancer [M, U, L, Less, Ant, Post, type4, T3(SS), N0, M0 (H0, P0, CY0), ypStage IIA]. Adjuvant chemotherapy (S-1) was commenced. The patient is still alive 7 months later with no evidence of recurrence. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s13691-023-00628-4 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38187176 ● Search Scopus @ Elsevier (PMID): 38187176 ● Search Scopus @ Elsevier (DOI): 10.1007/s13691-023-00628-4 (DOI: 10.1007/s13691-023-00628-4, PubMed: 38187176)
5.	Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto : Visualization of the pelvic nerves using magnetic resonance imaging for rectal cancer surgery., Surgical Endoscopy, Vol.37, No.6, 4315-4320, 2023. (要約) This study evaluated the visualization of the pelvic nerves using magnetic resonance imaging (MRI) combined with computed tomography (CT) to synthesize three-dimensional (3D) reconstruction images of the pelvic organs. The CT and MRI scans were performed for patients with rectal cancer who underwent surgery. The out-of-phase image of LAVA-Flex was used to identify the pelvic nerves. The images of the pelvic nerves were extracted from the MRI scans, and those of the arteries and rectum and pelvis were extracted from the CT scans. Each extracted organ image was used to synthesize 3D reconstruction images. The MRI scan allowed adequate visualization of the pelvic splanchnic nerves, inferior hypogastric plexus, and obturator nerves. The comparison of 3D reconstruction images and intraoperative findings showed matched images. We visualized the pelvic nerves using MRI and synthesized 3D reconstruction images of the pelvic organs. Preoperative confirmation of the location of the pelvic organs is important to prevent unanticipated injury during rectal cancer surgery. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00464-022-09771-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36418640 ● Search Scopus @ Elsevier (PMID): 36418640 ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-022-09771-0 (DOI: 10.1007/s00464-022-09771-0, PubMed: 36418640)
6.	Masaaki Nishi, Yuuma Wada, Kouzou Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada : Utility of robotic surgery for Siewert type II/III adenocarcinoma of esophagogastric junction: transhiatal robotic versus laparoscopic approach., BMC Surgery, Vol.23, No.1, 128, 2023. (要約) Robotic surgery (RS) has been rapidly adopted for gastric cancer and adenocarcinoma of the esophagogastric junction (AEG). However, the utility of RS for Siewert type II/III AEG remains unclear. Forty-one patients who underwent either transhiatal RS (n = 15) or laparoscopic surgery (LS) (n = 26) for Siewert type II/III AEG were enrolled in this study. The surgical outcomes of the two groups were compared. In the entire cohort, there were no significant intergroup differences in the operative time, blood loss volume, or number of retrieved lymph nodes. The length of the postoperative hospital stay was shorter in the RS group than in the LS group (14.20 ± 7.10 days vs. 18.73 ± 17.82 days, respectively; p = 0.0388). The morbidity rate (Clavien-Dindo grade ≥ 2) was similar between the groups. In the Siewert II cohort, there were no significant intergroup differences in short-term outcomes. In the entire cohort, there was no significant difference between the RS and LS groups in the 3-year overall survival rate (91.67% vs. 91.48%, N.S.) or 3-year disease-free survival rate (91.67% vs. 91.78%, N.S.), respectively. Likewise, in the Siewert type II cohort, there was no significant difference between the RS and LS groups in the 3-year overall survival rate (80.00% vs. 93.33%, N.S.) or 3-year disease-free survival rate (80.00% vs. 94.12%, N.S.), respectively. Transhiatal RS for Siewert II/III AEG was safe and contributed to similar short-term and long-term outcomes compared with LS. (キーワード) Humans / Robotic Surgical Procedures / Retrospective Studies / Gastrectomy / Adenocarcinoma / Stomach Neoplasms / Laparoscopy / Esophagogastric Junction / Esophageal Neoplasms (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12893-023-02045-z (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37194030 ● Search Scopus @ Elsevier (PMID): 37194030 ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-023-02045-z (DOI: 10.1186/s12893-023-02045-z, PubMed: 37194030)
7.	Kouzou Yoshikawa, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada and Toshiaki Yoshimoto : The application of enhanced recovery after surgery in total gastrectomy: a propensity score-matched analysis., World Journal of Surgical Oncology, Vol.21, No.1, 148, 2023. (要約) This study aimed to investigate the feasibility and safety of our enhanced recovery after surgery protocol including early oral intake and omitting nasogastric tube (NGT) placement after total gastrectomy. We analyzed 182 consecutive patients who underwent total gastrectomy. The clinical pathway was changed in 2015, and patients were divided into 2 groups (conventional group and modified group). Postoperative complications, bowel movement, and postoperative hospital stays were compared in the two groups in all cases and propensity score matching (PSM). Flatus and defecation were significantly earlier in the modified group compared with those in the conventional group (flatus: 2 (1-5) days vs 3 (2-12) days, p = 0.03; defecation: 4 (1-14) days vs 6 (2-12) days p = 0.04). The postoperative hospital stay was 18 (6-90) days in the conventional group and 14 (7-74) days in the modified group (p = 0.009). Days until discharge criteria were met were earlier in the modified group compared with that in the conventional group (10 (7-69) days vs 14 (6-84) days p = 0.01). Overall and severe complications occurred in nine patients (12.6%) and three patients (4.2%) in the conventional group and twelve patients (10.8%) and four patients (3.6%) in the modified group, respectively (p = 0.70 and p = 0.83) in all cases. In PSM, there is no significant difference between the two groups concerning the postoperative complications (overall complication 6 (12.5%) vs 8 (16.7%) p = 0.56, severe complications 1 (2%) vs 2 (4.2%) p = 0.83). Modified ERAS for total gastrectomy may be feasible and safe. (キーワード) Humans / Enhanced Recovery After Surgery / Propensity Score / Flatulence / Stomach Neoplasms / Retrospective Studies / Gastrectomy / Length of Stay / Postoperative Complications / Treatment Outcome / Laparoscopy (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12957-023-03034-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37194033 ● Search Scopus @ Elsevier (PMID): 37194033 ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-023-03034-5 (DOI: 10.1186/s12957-023-03034-5, PubMed: 37194033)
8.	Toshiaki Yoshimoto, Kouzou Yoshikawa, Toshihiro Nakao, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada, Takayuki Noma and Mitsuo Shimada : Surgical Outcomes of Gastrectomy in Hemodialysis Patients with Gastric Cancer., The American Surgeon, Vol.89, No.12, 6328-6330, 2023. (キーワード) Humans / Stomach Neoplasms / Retrospective Studies / Laparoscopy / Gastrectomy / Treatment Outcome / Renal Dialysis (出版サイトへのリンク) ● Publication site (DOI): 10.1177/00031348231173970 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37132264 ● Search Scopus @ Elsevier (PMID): 37132264 ● Search Scopus @ Elsevier (DOI): 10.1177/00031348231173970 (DOI: 10.1177/00031348231173970, PubMed: 37132264)
9.	Takuya Tokunaga, Maki Sugimoto, Yu Saitou, Hideya Kashihara, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Yuuma Wada, Yuhei Waki, Toshiaki Yoshimoto, Takayuki Noma and Mitsuo Shimada : Transanal lateral lymph node dissection with intraoperative hologram support in low rectal cancer., Surgical Endoscopy, Vol.37, No.7, 5414-5420, 2023. (要約) In Japan, the standard treatment for stage II/III advanced low rectal cancer is total mesorectal excision plus lateral lymph node dissection (LLND). There are also recent reports on the use of transanal LLND. However, the transanal anatomy is difficult to understand, and additional support tools are required to improve the surgical safety. The present study examined the utility of holograms with mixed reality as an intraoperative support tool for assessing the complex pelvic anatomy. Polygon (stereolithography) files of patients' pelvic organs were created and exported from the SYNAPSE VINCENT imaging system and uploaded into the Holoeyes MD virtual reality software. Three-dimensional images were automatically converted into patient-specific holograms. Each hologram was then installed into a head mount display (HoloLens2), and the surgeons and assistants wore the HoloLens2 when they performed transanal LLND. Twelve digestive surgeons with prior practice in hologram manipulation evaluated the utility of the intraoperative hologram support by means of a questionnaire. Intraoperative hologram support improved the surgical understanding of the lateral lymph node region anatomy. In the questionnaire, 75% of the surgeons answered that the hologram accurately reflected the anatomy, and 92% of the surgeons answered that the anatomy was better understood by simulating the hologram intraoperatively than preoperatively. Moreover, 92% of the surgeons agreed that intraoperative holograms were a useful support tool for improving the surgical safety. Intraoperative hologram support improved the surgical understanding of the pelvic anatomy for transanal LLND. Intraoperative holograms may represent a next-generation surgical tool for transanal LLND. (キーワード) Humans / Treatment Outcome / Lymph Node Excision / Lymph Nodes / Rectal Neoplasms / Dissection (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00464-023-09977-w (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37017769 ● Search Scopus @ Elsevier (PMID): 37017769 ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-023-09977-w (DOI: 10.1007/s00464-023-09977-w, PubMed: 37017769)
10.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Shohei Eto and Toshiaki Yoshimoto : Usefulness of Diagnostic Staging Laparoscopy for Advanced Gastric Cancer., The American Surgeon, Vol.89, No.4, 685-690, 2023. (要約) For advanced gastric cancer (AGC), peritoneal metastasis is the most common determinant of unresectability, but accurate preoperative diagnosis for peritoneal metastasis is challenging. Staging laparoscopy (SL) can detect unsuspected peritoneal metastasis. This study retrospectively evaluated the utility of SL and its indication in patients with AGC. In this study, we enrolled 114 patients with pathologically diagnosed gastric adenocarcinoma who underwent SL. Of the 114 patients, 43 (37.7%) had peritoneal metastasis (P1 or CY1). Higher age, larger tumor size, type 4 GC, deeper tumor depth, elevated CA125, and ascites findings in preoperative CT were found to be significant predictors of peritoneal metastasis. In multivariate analysis, peritoneal metastasis was associated with type 4 GC (odds ratio [OR]: 6.11; 95% confidence interval [CI]: 1.87-19.8; P < .01) and ascites in CT (OR: 4.25; 95% CI: 1.48-12.1; P < .01). Staging laparoscopy is an effective tool to detect peritoneal metastasis from AGC. It can increase the curative resection rate and decrease unnecessary laparotomies. (出版サイトへのリンク) ● Publication site (DOI): 10.1177/00031348211038554 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34382447 ● Search Scopus @ Elsevier (PMID): 34382447 ● Search Scopus @ Elsevier (DOI): 10.1177/00031348211038554 (DOI: 10.1177/00031348211038554, PubMed: 34382447)
11.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Shohei Eto and Toshiaki Yoshimoto : Transoral Anvil Delivery System With Tension-Free Method for Esophagojejunostomy After Laparoscopic Total Gastrectomy Prevents The Postoperative Stenosis., The American Surgeon, Vol.89, No.4, 1066-1068, 2023. (出版サイトへのリンク) ● Publication site (DOI): 10.1177/0003134820973393 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33307725 ● Search Scopus @ Elsevier (PMID): 33307725 ● Search Scopus @ Elsevier (DOI): 10.1177/0003134820973393 (DOI: 10.1177/0003134820973393, PubMed: 33307725)
12.	Kouzou Yoshikawa, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada and Toshiaki Yoshimoto : Stapler insertion angle toward the esophagus reduces the incidence of early postoperative Roux stasis syndrome after distal gastrectomy in minimally invasive surgery., BMC Surgery, Vol.23, No.1, 54, 2023. (要約) Roux stasis syndrome (RSS) after Roux-en-Y (RY) reconstruction significantly prolongs the hospital stay and decreases the quality of life. The purpose of the present study was to evaluate the incidence of RSS in patients who underwent distal gastrectomy for gastric cancer and to identify the factors related to the development of RSS after mechanical RY reconstruction in minimally invasive surgery (MIS). This study included 134 patients who underwent distal gastrectomy in MIS with mechanical RY anastomosis. RSS was defined as the presence of symptoms such as nausea, vomiting, or abdominal fullness, and the confirmation of delayed gastric emptying on imaging or gastrointestinal fiber testing. Clinical data were checked, including body mass index, operative procedure, age, sex, operative time, blood loss volume, extent of lymph node dissection, final stage, stapler insertion angle, method of entry hole closure. The relationship between the incidence of RSS and these factors was analyzed. RSS occurred in 24 of 134 patients (17.9%). RSS occurred significantly more frequently in patients with D2 lymphadenectomy than in patients with D1 + lymphadenectomy (p = 0.04). All patients underwent side-to-side anastomosis via the antecolic route. The incidence of RSS was significantly greater in patients with a stapler insertion angle toward the greater curvature (n = 20, 22.5%) versus the esophagus (n = 4, 8.9%) (p = 0.04). The multivariate logistic regression model revealed that the stapler insertion angle to the greater curvature is identified as independent risk factor for RSS (OR 3.23, 95%Cl 1.01-10.3, p = 0.04). Stapler insertion angle toward the esophagus may reduce the incidence of early postoperative RSS rather than toward the greater curvature. (キーワード) Humans / Incidence / Quality of Life / Gastrectomy / Anastomosis, Roux-en-Y / Esophagus / Stomach Neoplasms / Minimally Invasive Surgical Procedures / Postoperative Complications (徳島大学機関リポジトリ) ● Metadata: 118879 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12893-023-01954-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36906525 ● Search Scopus @ Elsevier (PMID): 36906525 ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-023-01954-3 (徳島大学機関リポジトリ: 118879, DOI: 10.1186/s12893-023-01954-3, PubMed: 36906525)
13.	Yosuke Iwakawa, Masaaki Nishi, Yuuma Wada, Kouzou Yoshikawa, Chie Takasu, Mitsuo Shimada, Yasuyo Saijo, Minoru Matsumoto, Takeshi Oya and Hisanori Uehara : Pleomorphic type undifferentiated gastric sarcoma, report of a case., Clinical Journal of Gastroenterology, Vol.16, No.1, 20-25, 2023. (要約) Reports on pleomorphic type of undifferentiated sarcoma (PUS) originating from the gastrointestinal tract, especially the stomach, are extremely rare. We herein report a case of pleomorphic type undifferentiated gastric sarcoma. The patient was a 67-year-old woman. The chief complaint was upper abdominal pain. Upper gastrointestinal endoscopy, ultrasonography, and contrast-enhanced computed tomography showed two submucosal tumors at the greater curvature of the fundus and the lesser curvature of the gastric angle. Endoscopic ultrasound-guided fine-needle aspiration revealed a c-kit-negative spindle cell tumor at the greater curvature of the fundus. Total gastrectomy, splenectomy, and partial resection of the diaphragm and liver were performed. One lesion had invaded the lateral segment of the liver, left diaphragm and spleen. The postoperative course was uneventful. Histopathological and immunohistochemical examinations of the resected specimen revealed PUS. Peritoneal dissemination was detected at 8 months after surgery. However, no effective therapeutic agents were adopted for chemotherapy. The patient had poor performance status due to disease progression and underwent best supportive care. The patient died 10 months after surgery. This case highlights the imaging, histological diagnosis, and treatment strategy for PUS originating from the stomach. Surgeons should be aware of PUS as a differential diagnosis in cases with submucosal tumor of the stomach. (キーワード) Female / Humans / Aged / Stomach Neoplasms / Gastrectomy / Sarcoma / Endoscopy, Digestive System / Liver Neoplasms (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12328-022-01729-y (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36289170 ● Search Scopus @ Elsevier (PMID): 36289170 ● Search Scopus @ Elsevier (DOI): 10.1007/s12328-022-01729-y (DOI: 10.1007/s12328-022-01729-y, PubMed: 36289170)
14.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto : The Impact of the Pre-operative Neutrophil-lymphocyte Ratio as the Predictive Marker of Post-operative Weight Loss and Improving Diabetes in Sleeve Gastrectomy., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 140-144, 2023. (要約) The aim was to investigate the impact of the neutrophil-lymphocyte ratio (NLR) in sleeve gastrectomy (SG). 15 obese patients were enrolled in this study ; mean body weight (BW) 127.5kg ; mean body mass index (BMI) 46.7kg/m. 10 of these were diabetics who underwent a SG. The impact of the pre-operative NLR on the percentage of excess weight loss (%EWL) and remission of diabetes 1 year post-operative were examined. The %EWL at 1 year post-operative were 46.3%. Improvements were also evident in the diabetes at 1 year post-operative : complete remission (CR) 40%, partial remission (PR) 20% and Improve 40%. Comparing pre-operative NLR in %EWL<50% and ≧50% in 1 year post-operative, <50% was 2.64 and ≧50% was 2.03. The NLR in CR and PR was significantly lower than that in Improve. The pre-operative NLR may be a predictive marker of weight loss and improving diabetes after SG. J. Med. Invest. 70 : 140-144, February, 2023. (キーワード) Humans / Obesity, Morbid / Treatment Outcome / Neutrophils / Retrospective Studies / Laparoscopy / Diabetes Mellitus / Weight Loss / Body Mass Index / Gastrectomy (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.140 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164710 ● Search Scopus @ Elsevier (PMID): 37164710 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.140 (DOI: 10.2152/jmi.70.140, PubMed: 37164710)
15.	Masaaki Nishi, Yuuma Wada, Kouzou Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Shin-ichiro Yamada, Toshiaki Yoshimoto and Mitsuo Shimada : Prognostic impact of frailty after gastrectomy in elderly gastric cancer patients., The Journal of Medical Investigation : JMI, Vol.70, No.3.4, 423-429, 2023. (要約) Frailty plays a crucial role in cancer patients who have received surgery in this recent aging society. We aimed to investigate frailty as a prognostic factor in elderly gastric cancer (GC) patients who underwent curative gastrectomy. We analyzed 86 elderly (over 75 years old) GC patients who underwent curative gastrectomy. Patients were assigned to two groups;frailty group (n=29) and no-frailty group (n=57). Clinicopathological values were compared between the two groups. The OS rate of the frailty group was significantly poorer than that of the no-frailty group (5-yr OS rate;frailty group 52.49% vs. no-frailty group 74.87%, p<0.05). Multivariate analysis of the OS showed that frailty tended to be significant prognostic factor (p=0.09). The DFS rate of the frailty group was significantly poorer than that of the no-frailty group (5-yr DFS rate;frailty group 42.30% vs. no-frailty group 71.55%, p<0.05). Multivariate analysis of the DFS showed that frailty tended to be significant prognostic factor (p=0.14). We identified the clinical impact of frailty prognostic factor for elderly GC patients who underwent gastrectomy. J. Med. Invest. 70 : 423-429, August, 2023. (キーワード) Humans / Aged / Prognosis / Stomach Neoplasms / Frailty / Aging / Gastrectomy / Retrospective Studies (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.423 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940527 ● Search Scopus @ Elsevier (PMID): 37940527 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.423 (DOI: 10.2152/jmi.70.423, PubMed: 37940527)
16.	Baasansuren Selenge, Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Hiroki Teraoku, Shohei Okikawa and Mitsuo Shimada : Impact of L-type amino acid transporter 1 on intrahepatic cholangiocarcinoma., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 160-165, 2023. (要約) Amino acid transporters, such as L-type amino acid transporter 1 (LAT1), have an effect on tumor growth, metastasis, and survival of various solid tumors. However, the role of LAT1 in patients with intrahepatic cholangiocarcinoma (IHCC) remains unknown. Forty-six patients who had undergone initial hepatic resection for IHCC at Tokushima University Hospital were enrolled in this study. Immunohistochemical analysis of LAT1 and phosphorylated Akt (p-AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were analyzed between LAT1-high and LAT1-low groups. The LAT1-high group showed a higher proportion of periductal infiltrating type and higher carcinoembryonic antigen/carbohydrate antigen 19-9 levels compared with the LAT1-low group. Multivariate analysis revealed that LAT1-high expression was an independent prognostic factor for disease-free survival. Furthermore, the proportion of p-AKT positivity was higher in the LAT1-high group than in the LAT1-low group. LAT1 expression was associated with poor prognosis of IHCC and higher p-Akt expression. J. Med. Invest. 70 : 160-165, February, 2023. (キーワード) Humans / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Biomarkers, Tumor / Cholangiocarcinoma / Prognosis / Proto-Oncogene Proteins c-akt (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.160 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164714 ● Search Scopus @ Elsevier (PMID): 37164714 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.160 (DOI: 10.2152/jmi.70.160, PubMed: 37164714)
17.	Chie Takasu, Masaaki Nishi, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto, Shohei Okikawa, Shoko Yamashita and Mitsuo Shimada : Role of IDO expression in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy., BMC Cancer, Vol.22, No.1, 1263, 2022. (要約) The role of the immune system in locally advanced rectal cancer (LARC) following preoperative chemoradiotherapy (CRT) has been widely investigated in recent years. This study examined the prognostic significance of indoleamine-pyrrole 2,3-dioxygenase (IDO) expression in patients with LARC who received preoperative CRT. Ninety patients with LARC who underwent preoperative CRT and curative resection were enrolled. IDO and programmed death-ligand 1 (PD-L1) expression was evaluated by immunohistochemistry. Clinicopathological factors did not significantly differ between patients with positive or negative IDO expression, excluding the correlation of positive IDO expression with better tumor differentiation (p = 0.02). IDO expression was not associated with pathological response (p = 0.44), but it was associated with PD-L1 expression. The 5-year overall survival (OS) rate was significantly worse in the IDO-positive group than in the IDO-negative group (64.8% vs. 85.4%, p = 0.02). Univariate analysis identified IDO and PD-L1 expression (p = 0.02), surgical procedure (p = 0.01), final pathological stage (p = 0.003), lymph node metastasis (p < 0.001), and lymphatic invasion (p = 0.002) as significant prognostic factors for OS. Multivariate analysis revealed that IDO expression (HR: 7.10, p = 0.0006), surgical procedure (HR: 5.03, p = 0.01), lymph node metastasis (HR: 2.37, p = 0.04) and lymphatic invasion (HR: 4.97, p = 0.01) were independent prognostic indicators. Disease-free survival was not correlated with IDO or PD-L1 expression. IDO expression in patients with LARC who received preoperative CRT could be a potential prognostic indicator. IDO expression could be a useful marker for specifying individual treatment strategies in LARC. (キーワード) Humans / B7-H1 Antigen / Chemoradiotherapy / Lymphatic Metastasis / Neoadjuvant Therapy / Prognosis / Rectal Neoplasms / Indoleamine-Pyrrole 2,3,-Dioxygenase (徳島大学機関リポジトリ) ● Metadata: 118002 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12885-022-10357-1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36471264 ● Search Scopus @ Elsevier (PMID): 36471264 ● Search Scopus @ Elsevier (DOI): 10.1186/s12885-022-10357-1 (徳島大学機関リポジトリ: 118002, DOI: 10.1186/s12885-022-10357-1, PubMed: 36471264)
18.	髙須千絵, 調憲, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 : オンライン時代は女性医師キャリア形成の追い風となる, 日本消化器外科学会雑誌, Vol.55, No.11, 729-732, 2022年. (要約) 新型コロナウイルス感染症の拡大が,これまで停滞していた医師の働き方改革の推進へとつながっている.その中でも,学会のオンライン化は医師の働き方に大きな変化をもたらした.学会のリモート参加は,自宅に居ながら参加でき,地方からも参加しやすく,移動時間と費用の大きな削減となる.オンデマンド配信は,時間・場所にかかわらず学ぶ機会を得られる非常に有効なツールとなる.また,学会の委員活動など,習慣的に行われていた対面での会議が,現在はほぼ遠隔で行われている.これまで時間的制約により,積極的に学会活動に手を挙げることができなかった女性医師の同分野での活躍推進が期待される.特に子育て中の女性医師にとって,オンライン化はワーク・ライフ・バランスを維持しながらキャリアを形成していく有効なツールとなりうる.この変化を逃さず女性活躍推進へとつなげるための,オンライン学会(ハイブリット形式)の継続を強く要望したい.(著者抄録) (キーワード) 育児労働衛生女性医師抄録作成と索引作成職歴の移動テレビ会議テレワーキングヒト女 (出版サイトへのリンク) ● Publication site (DOI): 10.5833/jjgs.2022.sr005 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390857226420483072 ● Search Scopus @ Elsevier (DOI): 10.5833/jjgs.2022.sr005 (DOI: 10.5833/jjgs.2022.sr005, CiNii: 1390857226420483072)
19.	Baasansvren Selenge, Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Hiroki Teraoku and Mitsuo Shimada : Impact of L-type amino acid transporter 3 on the prognosis of hepatocellular carcinoma., Oncology Letters, Vol.24, No.5, 418, 2022. (要約) The aim of the present study was to investigate the impact of L-type amino acid transporter 3 (LAT3) expression on the prognosis of hepatocellular carcinoma (HCC). A total of 135 patients who had undergone initial hepatic resection for HCC at Tokushima University Hospital (Tokushima, Japan) were enrolled in the present study. Immunohistochemical analysis of LAT3 and phosphorylated AKT (p-AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were compared between the LAT3-high and -low expression groups. The results demonstrated that the LAT3-high group showed significantly higher protein induced by vitamin K absence-II levels (P=0.01) compared with the LAT3-low group. The LAT3-high group showed significantly worse prognosis compared with the LAT3-low group regarding cancer-specific survival and disease-free survival (P<0.05). Multivariate analysis revealed that high LAT3 expression and multiple tumors were independent prognostic factors for cancer-specific survival. Furthermore, the rate of p-AKT-positive cases was higher in the LAT3-high group than in the LAT3-low group. Overall, these findings suggested that LAT3 expression was associated with poor prognosis of HCC and high p-AKT expression. (徳島大学機関リポジトリ) ● Metadata: 118271 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ol.2022.13538 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36245821 ● Search Scopus @ Elsevier (PMID): 36245821 ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2022.13538 (徳島大学機関リポジトリ: 118271, DOI: 10.3892/ol.2022.13538, PubMed: 36245821)
20.	Yuuma Wada, Masaaki Nishi, Kouzou Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada : Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer., Oncology Letters, Vol.24, No.5, 415, 2022. (要約) Previous studies have revealed the usefulness of neoadjuvant chemotherapy (NAC) followed by surgery for clinical stage III gastric cancer (GC). The tumor volume at the primary tumor site (PT) is sometimes difficult to measure because of the luminal structure; therefore, evaluation of the lymph node (LN) response to NAC may help to more accurately predict survival outcomes. The present study therefore evaluated the LN response to NAC for prediction of survival outcomes in patients with GC. The study involved 160 patients with clinical stage III GC who underwent NAC (n=14) and upfront surgery (n=146). PT and LN responses to NAC were evaluated, various clinicopathological factors were evaluated and Cox proportional hazard regression analyses were performed to determine survival outcomes. Overall survival (OS) and disease-free survival (DFS) were not significantly different between patients who underwent NAC and those who underwent upfront surgery (OS, P=0.71; DFS, P=0.50). However, although there were no significant differences in PT responses, patients classified as LN non-responders to NAC had a significantly worse prognosis compared with patients classified as LN responders in terms of DFS (PT, P=0.93; LN, P<0.01) and OS (PT, P=0.84; LN, P<0.01). Moreover, a higher neutrophil-lymphocyte ratio tended to be associated with poor DFS [univariate: hazard ratio (HR)=4.23, P=0.06; multivariate: HR=6.45, P=0.04]. Finally, an LN response to NAC was significantly better for prediction of recurrence (univariate, HR=7.79, 95% confidence interval=1.16-63.51, P=0.02; multivariate, HR=7.44, P=0.01). Overall, the current study revealed the clinical importance of the LN response to NAC for predicting survival outcomes in patients with GC. These findings highlight the potential clinical impact of optimizing treatment strategies to improve the selection and management of patients. (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ol.2022.13535 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36245824 ● Search Scopus @ Elsevier (PMID): 36245824 ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2022.13535 (DOI: 10.3892/ol.2022.13535, PubMed: 36245824)
21.	Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto : Computed tomography texture analysis for the prediction of lateral pelvic lymph node metastasis of rectal cancer., World Journal of Surgical Oncology, Vol.20, No.1, 281, 2022. (要約) This study aimed to investigate the usefulness of computed tomography (CT) texture analysis in the diagnosis of lateral pelvic lymph node (LPLN) metastasis of rectal cancer. This was a retrospective cohort study of 45 patients with rectal cancer who underwent surgery with LPLN dissection at Tokushima University Hospital from January 2017 to December 2021. The texture analysis of the LPLNs was performed on preoperative CT images, and 18 parameters were calculated. The correlation between each parameter and pathological LPLN metastasis was evaluated. The texture parameters were compared between pathologically metastasis-positive LPLNs and metastasis-negative LPLNs. A total of 40 LPLNs were extracted from 25 patients by preoperative CT scans. No LPLNs could be identified in the remaining 19 patients. Eight of the 25 patients had pathologically positive LPLN metastasis. Extracted LPLNs were analyzed by the texture analysis. Pathologically metastasis-positive LPLNs had significantly lower mean Hounsfield unit, gray-level co-occurrence matrix (GLCM) energy, and GLCM Entropy_log2 values, and a significantly larger volume than pathologically metastasis-negative LPLNs. Multivariate analysis revealed that the independent predictive factors for LPLN metastasis were volume (a conventional parameter) (odds ratio 7.81, 95% confidence interval 1.42-43.1, p value 0.018) and GLCM Entropy_log2 (a texture parameter) (odds ratio 12.7, 95% confidence interval 1.28-126.0, p value 0.030). The combination of both parameters improved the diagnostic specificity while maintaining the sensitivity compared with each parameter alone. Combining the CT texture analysis with conventional diagnostic imaging may increase the accuracy of the diagnosis of LPLN metastasis of rectal cancer. (キーワード) Humans / Lymph Node Excision / Lymph Nodes / Lymphatic Metastasis / Rectal Neoplasms / Retrospective Studies / Tomography, X-Ray Computed (徳島大学機関リポジトリ) ● Metadata: 118078 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12957-022-02750-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36057660 ● Search Scopus @ Elsevier (PMID): 36057660 ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-022-02750-8 (徳島大学機関リポジトリ: 118078, DOI: 10.1186/s12957-022-02750-8, PubMed: 36057660)
22.	Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto and Syoko Yamashita : Impact of osteopenia and neutropenia in patients with colorectal cancer treated with FOLFOXIRI: a retrospective cohort study., International Journal of Clinical Oncology, Vol.27, No.9, 1439-1449, 2022. (要約) This study was performed to assess the impact of osteopenia on chemotherapy-induced neutropenia and the prognosis for patients treated with FOLFOXIRI for colorectal cancer. In total, 77 patients who underwent FOLFOXIRI for un-resectable metastatic and advanced colorectal cancer were retrospectively evaluated. Osteopenia was evaluated by the bone mineral density, which was measured using the average pixel density of the trabecular bone in the 11th thoracic vertebra by computed tomography before the introduction of chemotherapy. The relationship between osteopenia and neutropenia was evaluated. Progression-free survival and overall survival of patients with osteopenia and patients with neutropenia were evaluated. Grade ≥ 3 neutropenia was significantly more common in patients with than without osteopenia (p = 0.002). The multivariate analysis showed that osteopenia was a significant independent predictive factor for grade ≥ 3 neutropenia (p = 0.016). There was no significant difference in progression-free survival or overall survival between patients with and without osteopenia. Patients with grade ≥ 3 neutropenia tended to have a higher progression-free survival rate than others (p = 0.059). The overall survival rate was significantly higher in patients with grade ≥ 3 neutropenia than in others (p = 0.011). Osteopenia might be a predictor of chemotherapy-induced neutropenia, and neutropenia might be a prognostic factor for progression-free survival and overall survival in patients with colorectal cancer treated with FOLFOXIRI. (キーワード) Antineoplastic Agents / Antineoplastic Combined Chemotherapy Protocols / Bevacizumab / Bone Diseases, Metabolic / Camptothecin / Colorectal Neoplasms / Fluorouracil / Humans / Leucovorin / Neutropenia / Organoplatinum Compounds / Retrospective Studies (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10147-022-02199-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35908137 ● Search Scopus @ Elsevier (PMID): 35908137 ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-022-02199-5 (DOI: 10.1007/s10147-022-02199-5, PubMed: 35908137)
23.	Takuya Tokunaga, Maki Sugimoto, Yu Saitou, Hideya Kashihara, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Shoko Yamashita, Yosuke Iwakawa, Noriko Yokota and Mitsuo Shimada : Intraoperative holographic image-guided surgery in a transanal approach for rectal cancer., Langenbeck's Archives of Surgery / Deutsche Gesellschaft für Chirurgie, Vol.407, No.6, 2579-2584, 2022. (要約) Urethral injury is one of the most important complications in transanal total mesorectal excision (TaTME) in male patients with rectal cancer. The purpose of this study was to investigate holographic image-guided surgery in TaTME. Polygon (stereolithography) files were created and exported from SYNAPSE VINCENT, and then uploaded into the Holoeyes MD system (Holoeyes Inc., Tokyo, Japan). After uploading the data, the three-dimensional image was automatically converted into a case-specific hologram. The hologram was then installed into the head mount display, HoloLens (Microsoft Corporation, Redmond, WA). The surgeons and assistants wore the HoloLens when they performed TaTME. In a Wi-Fi-enabled operating room, each surgeon, wearing a HoloLens, shared the same hologram and succeeded in adjusting the hologram by making simple hand gestures from their respective angles. The hologram contributed to better comprehension of the positional relationships between the urethra and the surrounding pelvic organs during surgery. All surgeons were able to properly determine the dissection line. This first experience suggests that intraoperative holograms contributed to reducing the risk of urethral injury and understanding transanal anatomy. Intraoperative holograms have the potential to become a new next-generation surgical support tool for use in spatial awareness and the sharing of information between surgeons. (キーワード) Dissection / Humans / Laparoscopy / Male / Postoperative Complications / Proctectomy / Rectal Neoplasms / Rectum / Surgery, Computer-Assisted / Transanal Endoscopic Surgery (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00423-022-02607-4 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35840706 ● Search Scopus @ Elsevier (PMID): 35840706 ● Search Scopus @ Elsevier (DOI): 10.1007/s00423-022-02607-4 (DOI: 10.1007/s00423-022-02607-4, PubMed: 35840706)
24.	Yuuma Wada, Masaaki Nishi, Kozo Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada : Preoperative nutrition and exercise intervention in frailty patients with gastric cancer undergoing gastrectomy., International Journal of Clinical Oncology, Vol.27, No.9, 1421-1427, 2022. (要約) The frailty was associated with the worse surgical outcomes and poor prognosis in several cancers. Therefore, we aimed to identify the usefulness of nutrition and exercise intervention (NEI) in frailty patients with GC. We analyzed 58 frailty patients with GC who underwent radical surgery. Among these, 15 patients were performed NEI by nutritional and rehabilitation support team. We compared the surgical outcomes between NEI and non-NEI groups with frailty patients and evaluated the nutrition and rehabilitation markers in pre- and post-NEI groups. The postoperative complication of NEI groups was 6.7% and less than that of non-NEI groups (p = 0.08). The mean postoperative hospital stay of NEI groups was 13.0 ± 1.0 days for NEI groups and significantly shorter than that of non-NEI groups (p = 0.03). The NLR was 4.3 ± 0.6 for pre-NEI and significantly improved by NEI between pre- and post-NEI (p = 0.03). We identified the clinical importance of NEI for improving the surgical outcomes in frailty patients with GC. Our findings highlight the potential clinical impact of optimizing treatment strategies to select and manage the frailty patients. (キーワード) Exercise Therapy / Frailty / Gastrectomy / Humans / Postoperative Complications / Preoperative Care / Stomach Neoplasms (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10147-022-02202-z (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35771395 ● Search Scopus @ Elsevier (PMID): 35771395 ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-022-02202-z (DOI: 10.1007/s10147-022-02202-z, PubMed: 35771395)
25.	Shuhai Chen, Masaaki Nishi, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Akiko Nakamoto, Tohru Sakai and Mitsuo Shimada : Polymethoxylated flavone sudachitin is a safe anticancer adjuvant that targets glycolysis in cancer-associated fibroblasts., Oncology Letters, Vol.24, No.1, 236, 2022. (要約) Sudachitin is a polymethoxylated flavone found in the peel of , a unique specialty citrus fruit in Tokushima Prefecture, Japan. Previous reports have demonstrated that sudachitin has anti-inflammatory and metabolic regulatory activities. However, to the best of our knowledge, no studies have explored whether sudachitin can act as an antitumor therapeutic agent by regulating metabolic functions in the tumor microenvironment. In the present study, cell proliferation and cytotoxicity assays were used to determine whether sudachitin inhibited the growth of liver cancer and pancreatic carcinoma, cholangiocarcinoma and colorectal cancer cells and to compare its toxicity against normal fibroblasts and induced cancer-associated fibroblasts (CAFs). Using lactate assays and reverse transcription-quantitative PCR, the effects of sudachitin on glycolysis in CAFs were investigated. The effects of CAFs on malignant tumor cells were evaluated using cell proliferation, wound healing and invasion assays. As result, sudachitin inhibited various types of tumor cells with different half-maximal inhibitory concentrations. Treatment with 50 µM sudachitin for 48 h suppressed tumor and CAFs proliferation but was not cytotoxic against normal fibroblasts. This dose also inhibited glycolysis in CAFs and, thus, diminished their pro-tumorigenic activities. Overall, the present study revealed that sudachitin has promise as a safe and widely available natural antitumor adjuvant. (徳島大学機関リポジトリ) ● Metadata: 118072 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ol.2022.13356 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35720469 ● Search Scopus @ Elsevier (PMID): 35720469 ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2022.13356 (徳島大学機関リポジトリ: 118072, DOI: 10.3892/ol.2022.13356, PubMed: 35720469)
26.	Masaaki Nishi, Yuuma Wada, Kouzou Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto, Chiharu Nakasu and Mitsuo Shimada : Pincer Approach to Gastrosplenic Ligament in Robotic Total Gastrectomy for Gastric Cancer., Journal of Gastrointestinal Surgery, Vol.26, No.7, 1552-1555, 2022. (キーワード) Gastrectomy / Humans / Laparoscopy / Ligaments / Retrospective Studies / Robotic Surgical Procedures / Robotics / Stomach Neoplasms / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s11605-022-05356-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35578006 ● Search Scopus @ Elsevier (PMID): 35578006 ● Search Scopus @ Elsevier (DOI): 10.1007/s11605-022-05356-3 (DOI: 10.1007/s11605-022-05356-3, PubMed: 35578006)
27.	Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Syoko Yamashita and Yosuke Iwakawa : Vascular variations encountered during laparoscopic surgery for transverse colon, splenic flexure, and descending colon cancer: a retrospective cohort study., BMC Surgery, Vol.22, No.1, 170, 2022. (要約) Laparoscopic surgery for cancer located in the transverse colon or splenic flexure is difficult because of vascular variability in this region and adjacent vital organs such as the pancreas, spleen, and duodenum. This retrospective cohort study involved 51 patients who underwent laparoscopic surgery for colon cancer at Tokushima University Hospital from July 2015 to December 2020. Variations of the middle colic artery (MCA), left colic artery (LCA), middle colic vein (MCV), and first jejunal vein (FJV) and short-term outcomes of laparoscopic surgery in patients with each vascular variation were evaluated. Variations of the MCA, LCA, MCV, and FJV were classified into four, three, five, and three patterns, respectively. The short-term outcomes of laparoscopic surgery for transverse colon cancer in patients with MCA variations and those with FJV variations were evaluated, and no significant difference was found in the operation time, blood loss, postoperative complication rate, time from surgery to start of dietary intake, or time from surgery to discharge among the different variations. Additionally, no significant differences were found in the short-term outcomes of laparoscopic surgery for descending colon cancer in patients with LCA variations. Preoperative assessment of vascular variations may contribute to the stability of short-term outcomes of laparoscopic surgery for transverse colon, splenic flexure, and descending colon cancer. (キーワード) Colectomy / Colon, Descending / Colon, Transverse / Colonic Neoplasms / Humans / Laparoscopy / Retrospective Studies (徳島大学機関リポジトリ) ● Metadata: 118005 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12893-022-01603-1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35538458 ● Search Scopus @ Elsevier (PMID): 35538458 ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-022-01603-1 (徳島大学機関リポジトリ: 118005, DOI: 10.1186/s12893-022-01603-1, PubMed: 35538458)
28.	Toshiaki Yoshimoto, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada, Shohei Okikawa and Kouzou Yoshikawa : Blue light irradiation inhibits the growth of colon cancer and activation of cancer-associated fibroblasts., Oncology Reports, Vol.47, No.5, 2022. (要約) Irradiation with a specific wavelength of light using light-emitting diodes (LEDs) has various effects on cells and organisms. Recently, the antitumor effects of visible blue light on tumor cells were reported; however, the mechanism and effects on the tumor microenvironment remain unclear. Human colon cancer cells (HCT-116) were injected into the rectal wall of nude mice. Tumors were irradiated with a 465-nm LED light at 30 mW/cm for 30 min. Tumor volumes and the expression levels of opsin 3 (Opn3), autophagy-related factors, cancer-associated fibroblast (CAF) markers, and programmed cell death 1-ligand (PD-L1) were measured. Additionally, human intestinal fibroblasts were cultured in HCT116-conditioned medium (CM) to prepare CAFs. CAFs were divided into an LED group and a control group, and the effect of the LED light on CAF activation in colon cancer cells was examined. Irradiation with blue LED light suppressed tumor growth; Opn3 expression was localized to the cell membrane in the LED group. Irradiated tumors exhibited increased autophagy-related gene expression. Furthermore, in the LED group, TGF-β and α-SMA expression levels in the fibroblasts were decreased. Regarding CAFs, α-SMA and IL-6 expression levels were decreased in the LED group. HCT-116 cells cultured in CAF-CM with LED irradiation showed no enhanced migration or invasion. In the HCT-116 cells cultured in CM of CAFs irradiated with LED, the relative increase in PD-L1 expression was lower than that noted in the CAF-CM without LED irradiation. Blue LED light may have a direct antitumor effect on colon cancer and also an inhibitory effect on CAFs. (キーワード) Animals / B7-H1 Antigen / Cancer-Associated Fibroblasts / Cell Movement / Cell Proliferation / Colonic Neoplasms / HCT116 Cells / Humans / Light / Mice / Mice, Nude / Rod Opsins / Tumor Microenvironment (徳島大学機関リポジトリ) ● Metadata: 118073 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/or.2022.8315 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35417035 ● Search Scopus @ Elsevier (PMID): 35417035 ● Search Scopus @ Elsevier (DOI): 10.3892/or.2022.8315 (徳島大学機関リポジトリ: 118073, DOI: 10.3892/or.2022.8315, PubMed: 35417035)
29.	Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Syoko Yamashita and Yosuke Iwakawa : Risk factors for postoperative ileus after diverting loop ileostomy closure., BMC Surgery, Vol.22, No.1, 131, 2022. (要約) Postoperative ileus is one of the most common complications after diverting loop ileostomy closure. Some reports have investigated the risk factors for postoperative complications or ileus after ileostomy closure; however, these studies did not evaluate the index surgery sufficiently. In this study, we evaluated the risk factors, including the details of the index surgery, for ileus after diverting ileostomy closure. This was a retrospective study of patients who underwent ileostomy closure following index surgery for rectal cancer. Patients who developed postoperative ileus [POI (+)] and patients who did not [POI (-)] after ileostomy closure were compared. Sixty-eight patients were evaluated and were divided into two groups: POI (+) (n = 11) and POI (-) (n = 57), and the groups were compared. There were no significant differences in the details of the index surgery, operative procedure, transanal total mesorectal excision, lateral lymph node dissection, operating time, or blood loss. The incidence of Clavien-Dindo grade ≥ III complications and adjuvant chemotherapy after index surgery were significantly higher in the POI (+) group. The incidence of Clavien-Dindo grade ≥ III complications and adjuvant chemotherapy after index surgery may increase the risk of postoperative ileus after ileostomy closure. (キーワード) Humans / Ileostomy / Ileus / Postoperative Complications / Rectal Neoplasms / Retrospective Studies / Risk Factors (徳島大学機関リポジトリ) ● Metadata: 118004 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12893-022-01583-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35392877 ● Search Scopus @ Elsevier (PMID): 35392877 ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-022-01583-2 (徳島大学機関リポジトリ: 118004, DOI: 10.1186/s12893-022-01583-2, PubMed: 35392877)
30.	西正暁, 島田光生, 森根裕二, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 良元俊昭, 和田佑馬 : 【外科代謝栄養と東洋医学:漢方による周術期管理へのサポート】大建中湯による周術期管理のサポート, 外科と代謝·栄養, Vol.56, No.2, 59-61, 2022年. (要約) 近年では漢方の分子生物学的な作用機序の解明が進み，臨床においても質の高いランダム化比較試験により漢方の有用性が明らかになってきた．現在では大建中湯を含む多くの漢方製剤が広く臨床の現場で用いられている．大建中湯は乾姜，人参，山椒の3つの生薬に膠飴を加えた漢方で，外科領域においては癒着性イレウスや麻痺性イレウス，過敏性腸症候群，クローン病などを適応とし，消化管運動促進作用，腸管血流増加作用，抗炎症作用などが報告されている．近年では，食道・胃・大腸・肝臓・膵臓・肝移植外科それぞれの領域でランダム化試験が実施され，大建中湯の周術期管理における有効性が証明されている．また分子生物学的なメカニズムについても解明がすすみ，現在，大建中湯は消化管外科・肝胆膵外科の分野を問わず消化器外科全般における周術期管理のkey drugとして位置付けられている．本稿では消化器外科領域における大建中湯による周術期管理のサポートについて概説する．(著者抄録) (キーワード) 消化管運動消化器外科バクテリアルトランスロケーション周術期管理 *大建中湯(薬理学,治療的利用) 伊東細胞腫瘍微小環境ヒト (出版サイトへのリンク) ● Publication site (DOI): 10.11638/jssmn.56.2_59 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.11638/jssmn.56.2_59 (DOI: 10.11638/jssmn.56.2_59)
31.	Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Shoko Yamashita and Yosuke Iwakawa : The correlation of immunoscore and frailty in colorectal cancer., International Journal of Clinical Oncology, Vol.27, No.3, 528-537, 2022. (要約) The Immunoscore is a useful prognostic and predictive factor for colorectal cancer. Frailty predicts overall and recurrence-free survival following resection of colorectal cancer, and the immunosuppressive state of frailty might affect tumor progression. This study investigated the relationship between the Immunoscore and frailty in colorectal cancer. This retrospective study included patients who underwent radical surgery for stage II and III colorectal cancer (n = 108). Patients were divided into frail (n = 11) and non-frail (n = 97) groups, and low (IS0-2) (n = 70) and high (IS3-4) Immunoscore groups (n = 38), for comparison. American Society of Anesthesiologists physical status was higher, tumor diameter was larger, number of well-differentiated tumors was higher, albumin was lower, 5-year overall survival (OS) was lower (frail group: 50.0%, non-frail group: 90.5%, p < 0.001) and 5-year disease-free survival (DFS) was lower (frail group: 36.4%, non-frail group: 75.2%, p = 0.024) in the frail than in the non-frail group. Left colon cancer was more, 5-year OS was lower (IS0-2 group: 82.0%, IS3-4 group: 96.7%, p = 0.040) and 5-year DFS was lower (IS0-2 group: 66.3%, IS3-4 group: 83.3%, p = 0.043) in the IS0-2 than in the IS3-4 group. The Immunoscore was lower in the frail than in the non-frail group. Immunoscore and frailty are prognostic and predictive factors in colorectal cancer, and they are correlated with each other. The immunosuppressive state from frailty might affect this correlation. (キーワード) Colonic Neoplasms / Colorectal Neoplasms / Disease-Free Survival / Frailty / Humans / Prognosis / Retrospective Studies (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10147-021-02096-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34846645 ● Search Scopus @ Elsevier (PMID): 34846645 ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-021-02096-3 (DOI: 10.1007/s10147-021-02096-3, PubMed: 34846645)
32.	Shuhai Chen, Masaaki Nishi, Yuji Morine, Mitsuo Shimada, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Shinichiro Yamada and Yuma Wada : Epigallocatechin 3allate hinders metabolic coupling to suppress colorectal cancer malignancy through targeting aerobic glycolysis in cancerssociated fibroblasts., International Journal of Oncology, Vol.60, No.2, 2022. (要約) In recent times, researchers working on tumor metabolism have paid increasing attention to the tumor microenvironment. Emerging evidence has confirmed that epigenetic modifications of cancerssociated fibroblasts (CAFs) alters the characteristics of glucose metabolism to achieve a symbiotic relationship with the cancer cells. Epigallocatechin 3allate (EGCG) exerts antiumor effects via a variety of mechanisms, although the underlying mechanism that accounts for the effects of EGCG on glucose metabolic alterations of CAFs have yet to be elucidated. In the present study, through coulture with colorectal cancer (CRC) cells, human intestinal fibroblasts were transformed into CAFs, and exhibited enhanced aerobic glycolysis. Induced CAFs were able to enhance the proliferation, migration and invasion of CRC cells . EGCG treatment led to direct inhibition of the proliferation and migration of CRC cells; furthermore, EGCG treatment of CAFs suppressed their tumorromoting capabilities by inhibiting their glycolytic activity. Blocking the lactic acid efflux of CAFs with a monocarboxylate transporter 4 (MCT4) inhibitor or through silencing MCT4 could also suppress their tumorromoting capabilities, indicating that lactate fulfills an important role in the metabolic coupling that occurs between CAFs and cancer cells. Taken together, the results of the present study showed that EGCG targeting of the metabolism of tumor stromal cells provided a safe and effective strategy of antiancer therapy. (キーワード) Cancer-Associated Fibroblasts / Catechin / Colorectal Neoplasms / Humans / Neoplasms / Oxidative Coupling / Warburg Effect, Oncologic (徳島大学機関リポジトリ) ● Metadata: 117318 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ijo.2022.5309 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35029285 ● Search Scopus @ Elsevier (PMID): 35029285 ● Search Scopus @ Elsevier (DOI): 10.3892/ijo.2022.5309 (徳島大学機関リポジトリ: 117318, DOI: 10.3892/ijo.2022.5309, PubMed: 35029285)
33.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto and Shoko Iwahashi : Usefulness of a stepwise training program for laparoscopic gastrectomy., Asian Journal of Endoscopic Surgery, Vol.15, No.1, 121-127, 2022. (要約) Laparoscopic gastrectomy (LG) is a complicated procedure with a long learning curve. This study was performed to investigate the usefulness of our stepwise training program for LG for improving the quality of the surgery. The stepwise training method comprised the following four steps: (1) basic training using a dry box and checking by mentors; (2) advanced training, including the use of animals and cadavers; (3) clinical experience, including standardization and preoperative three-dimensional simulation; and (4) self-assessment and feedback. In total, 153 patients who underwent curative gastrectomy for gastric cancer were included in this study. The operative time gradually decreased for both laparoscopic distal gastrectomy (LDG) (2013, 395inutes; 2017, 278inutes; P < .001; = -0.68) and laparoscopic total gastrectomy (LTG) (2013, 476inutes; 2017, 319inutes; P < .001; = -0.56). The blood loss volume gradually decreased for both LDG (2013, 43.0 mL; 2017, 18.6 mL; P < .005; = -0.30) and LTG (2013, 143.8 mL; 2017, 13.5 mL; P < .005; = -0.41). Our stepwise training program contributes to reduce operation time and blood loss in LG. (キーワード) Gastrectomy / Humans / Laparoscopy / Retrospective Studies / Stomach Neoplasms / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1111/ases.12979 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34514719 ● Search Scopus @ Elsevier (PMID): 34514719 ● Search Scopus @ Elsevier (DOI): 10.1111/ases.12979 (DOI: 10.1111/ases.12979, PubMed: 34514719)
34.	Shohei Eto, Kouzou Yoshikawa, Toshiaki Yoshimoto, Chie Takasu, Hideya Kashihara, Masaaki Nishi, Takuya Tokunaga, Toshihiro Nakao, Jun Higashijima, Takashi Iwata and Mitsuo Shimada : Strategy for laparoscopic repair of inguinal hernia after robot-assisted radical prostatectomy., Asian Journal of Endoscopic Surgery, Vol.15, No.1, 155-161, 2022. (要約) Robot-assisted radical prostatectomy (RARP) is nowadays being performed worldwide, and inguinal hernia (IH) continues to be a common complication of radical prostatectomy. Laparoscopic repair of IH is often difficult via internal dissection because of adhesion of the preperitoneal cavity. This study aimed to categorize the intraoperative condition of, and devise a strategy for, IH after RARP. Of 577 patients who underwent RARP, 18 developed IH. These 18 patients then underwent laparoscopic IH repair using the transabdominal preperitoneal approach (TAPP) or modified intraperitoneal onlay mesh repair (mIPOM). Internal dissection was categorized into two groups according to the appearance of Cooper's ligament (exposed or not exposed). After RARP, four patients had exposure of Cooper's ligament while 14 patients showed no exposure. Both patients in the exposed group underwent TAPP and all patients in the not-exposed group underwent mIPOM. There was no significant difference between normal TAPP and RARP regarding operative factors, and IH recurrence was not observed. Laparoscopic repair of IH after RARP is rendered safe and efficient by using our categorization based on the exposure of Cooper's ligament and extension of preperitoneal space. (キーワード) Hernia, Inguinal / Herniorrhaphy / Humans / Laparoscopy / Male / Prostatectomy / Robotics (出版サイトへのリンク) ● Publication site (DOI): 10.1111/ases.12985 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34514724 ● Search Scopus @ Elsevier (PMID): 34514724 ● Search Scopus @ Elsevier (DOI): 10.1111/ases.12985 (DOI: 10.1111/ases.12985, PubMed: 34514724)
35.	Chie Takasu, Emiko Kono, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Toshiaki Yoshimoto, Shoko Yamashita and Mitsuo Shimada : A "diversity and inclusion" lecture for promoting self-awareness among medical students., Surgery Today, Vol.52, No.6, 964-970, 2022. (要約) The concept of 'diversity and inclusion' is being adopted worldwide, but it is not yet understood well in Japan. We conducted this study to evaluate the impact of a lecture aimed at increasing awareness of academic careers and the benefits of having diversity and inclusion. Two female surgeons delivered a 120-min lecture on "diversity and inclusion" to third-year medical students at Tokushima University. To assess the impact of the lecture, a questionnaire was distributed, for participants to complete anonymously before and after the lecture. Eighty-two students participated in the study (39 men, 38 women, and 5 unknown). Based on the questionnaire responses, 57.1% of the students had already perceived inequality in conduct because of gender. A comparison of pre- and post-lecture responses revealed a significant increase in confidence to succeed in their medical career (56.5% vs. 77.5%, p < 0.01). Learners were more likely to believe that gender would not become a barrier to career development (42.4% vs. 66.7%, p < 0.01). Moreover, 90.4% of the students felt positively about a career in surgery following the lecture. The lecture promoted awareness about diversity, self-awareness, and career development and motivated students to consider specializing in surgery later in their career. (キーワード) Career Choice / Female / Gender Identity / Humans / Japan / Male / Students, Medical / Surveys and Questionnaires (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00595-021-02424-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35001195 ● Search Scopus @ Elsevier (PMID): 35001195 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-021-02424-0 (DOI: 10.1007/s00595-021-02424-0, PubMed: 35001195)
36.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Chie Takasu, Yuuma Wada, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Shoko Yamashita : Propensity Score-Matched Analysis of the Short- and Long-Term Outcomes of Robotic Versus Laparoscopic Gastrectomy for Gastric Cancer., Annals of Surgical Oncology, Vol.29, No.6, 3887-3895, 2022. (要約) Robotic gastrectomy (RG) has been rapidly adopted for gastric cancer (GC) treatment. However, the benefits of RG over laparoscopic gastrectomy (LG) for GC remain unclear. A total of 451 patients who underwent either RG (n = 83) or LG (n = 368) for GC were enrolled in this study. A 1:1 matched, propensity score-matched analysis was performed using the following factors: age, sex, body mass index, pT, pN, pStage, tumor location, vessel invasion, tumor markers, surgical procedure, reconstruction method, extent of lymphadenectomy, and Endoscopic Surgical Skill Qualification System qualified surgeon as an operator. The surgical outcomes of the two groups were compared. A well-balanced cohort of 158 patients was analyzed (n = 79 in the RG group, n = 79 in the LG group). Regarding the short-term outcomes, the respective blood loss volume, drain amylase content, and number of retrieved lymph nodes in the RG and LG groups were 38.62 ± 73.06 ml and 67.53 ± 108.20 ml (p < 0.05), 450 ± 371 IU/l and 1590 ± 6392 IU/l (p < 0.01), and 35.02 ± 15.51 and 25.28 ± 11.70 (p < 0.01). The morbidity rate was similar between the RG and LG groups (not significant [NS]). Regarding the long-term survival outcomes, there were no intergroup differences in 3-year overall survival (91.72% in the RG group vs. 83.39% in the LG group: NS) and 3-year, disease-free survival (93.31% in the vs. 90.44%: NS). RG was safe and contributed to better short-term outcomes and similar long-term survival outcomes compared with LG. (キーワード) Gastrectomy / Humans / Laparoscopy / Postoperative Complications / Propensity Score / Retrospective Studies / Robotic Surgical Procedures / Stomach Neoplasms / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1245/s10434-021-11203-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35006502 ● Search Scopus @ Elsevier (PMID): 35006502 ● Search Scopus @ Elsevier (DOI): 10.1245/s10434-021-11203-7 (DOI: 10.1245/s10434-021-11203-7, PubMed: 35006502)
37.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Chie Takasu and Yuuma Wada : ASO Author Reflections: The Role of Robotic Gastrectomy for Gastric Cancer., Annals of Surgical Oncology, Vol.29, No.6, 3896-3897, 2022. (キーワード) Gastrectomy / Humans / Robotic Surgical Procedures / Robotics / Stomach Neoplasms (出版サイトへのリンク) ● Publication site (DOI): 10.1245/s10434-021-11226-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34988837 ● Search Scopus @ Elsevier (PMID): 34988837 ● Search Scopus @ Elsevier (DOI): 10.1245/s10434-021-11226-0 (DOI: 10.1245/s10434-021-11226-0, PubMed: 34988837)
38.	Kouzou Yoshikawa, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto and Shoko Yamashita : Short-term outcomes of laparoscopic / robotic gastrectomy compared with open gastrectomy for advanced gastric cancer following chemotherapy., The Journal of Medical Investigation : JMI, Vol.69, No.3.4, 261-265, 2022. (要約) Purpose : This study aimed to investigate the short-term outcomes of laparoscopic gastrectomy / robotic gastrectomy after chemotherapy in patients with advanced gastric cancer and compare these outcomes with those of open gastrectomy. Methods : Fifty patients who underwent radical gastrectomy for advanced gastric cancer after chemotherapy between 2007 and 2021 were retrospectively analyzed. The patients were divided into two groups : the laparoscopic gastrectomy / robotic gastrectomy (n = 11) and open gastrectomy (n = 39) groups. The short-term outcomes of these procedures were subsequently examined. Results : The laparoscopic gastrectomy / robotic gastrectomy group had significantly shorter hospital stays and lower intraoperative blood loss than the open gastrectomy group. The overall complication rates were 12.8% (5 of 39 patients) and 0% (0 of 11 patients) in the open gastrectomy and laparoscopic gastrectomy / robotic gastrectomy groups, respectively (P = 0.1). Conclusions : Laparoscopic gastrectomy / robotic gastrectomy may be a surgical option after chemotherapy for patients with advanced gastric cancer. J. Med. Invest. 69 : 261-265, August, 2022. (キーワード) Gastrectomy / Humans / Laparoscopy / Retrospective Studies / Robotic Surgical Procedures / Stomach Neoplasms / Treatment Outcome (徳島大学機関リポジトリ) ● Metadata: 117728 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.69.261 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244778 ● Search Scopus @ Elsevier (PMID): 36244778 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.261 (徳島大学機関リポジトリ: 117728, DOI: 10.2152/jmi.69.261, PubMed: 36244778)
39.	Jun Higashijima, Toru Kono, Mitsuo Shimada, Ayumu Sugitani, Hideya Kashihara, Chie Takasu, Masaaki Nishi, Takuya Tokunaga and Kouzou Yoshikawa : High Ligation of the Inferior Mesenteric Artery Induces Hypoperfusion of the Sigmoid Colon Stump During Anterior Resection., Frontiers in Surgery, Vol.8, 756873, 2021. (要約) Anastomotic leakage (AL) after colorectal surgery is associated with insufficient vascular perfusion of the anastomotic ends. This study aimed to evaluate the effect of high vs. low ligation of the ileocolic artery and inferior mesenteric artery, respectively, on the vascular perfusion of the bowel stumps during ileocecal resection (ICR) and anterior rectal resection (AR). We retrospectively evaluated patients who underwent ICR or AR between 2016 and 2020. Real-time indocyanine green fluorescence angiography was performed to measure the fluorescence time (FT) as a marker of the blood flow in the proximal and distal stumps before anastomosis. Thirty-four patients with lower right-sided colon cancer underwent laparoscopic ICR. Forty-one patients with rectosigmoid colon or rectal cancer underwent robotic high AR (HAR) ( = 8), robotic low AR (LAR) ( = 6), laparoscopic HAR ( = 8), or laparoscopic LAR ( = 19). The FT was similar in the ileal and ascending colon stumps ( = 1.000) and did not differ significantly between high vs. low ligation of the ileocolic artery ( = 0.934). The FT was similar in the sigmoid colon and rectal stumps ( = 0.642), but high inferior mesenteric artery ligation significantly prolonged FT in the sigmoid colon during AR compared with low ligation ( = 0.004), indicating that the high ligation approach caused significant hypoperfusion compared with low ligation. The AL rate was similar after low vs. high ligation. Low vascular perfusion of the bowel stumps may not be an absolute risk factor for AL. High inferior mesenteric artery ligation could induce sigmoid colon stump hypoperfusion during anterior rectal resection. (徳島大学機関リポジトリ) ● Metadata: 117310 (出版サイトへのリンク) ● Publication site (DOI): 10.3389/fsurg.2021.756873 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34966775 ● Search Scopus @ Elsevier (PMID): 34966775 ● Search Scopus @ Elsevier (DOI): 10.3389/fsurg.2021.756873 (徳島大学機関リポジトリ: 117310, DOI: 10.3389/fsurg.2021.756873, PubMed: 34966775)
40.	Chie Takasu, Shoko Yamashita, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada : The role of the immunoescape in colorectal cancer liver metastasis., PLoS ONE, Vol.16, No.11, e0259940, 2021. (要約) The expression of programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) indicate the efficacy of anti-PD-1/PD-L1 therapy in colorectal cancer (CRC), but are less useful for monitoring the efficacy of therapy of CRC liver metastasis (CRLM). This study investigated the effects of immune molecules on the prognosis of CRLM. We enrolled 71 patients with CRLM who underwent curative resection for CRC. We used immunohistochemistry to analyze the expression of PD-1, PD-L1, indoleamine-pyrrole 2,3-dioxygenase (IDO), and CD163 (a marker of tumor-associated macrophages [TAMs]) in metastatic tumors. The immune molecules PD-1, PD-L1, IDO, and TAMs were expressed in 32.3%, 47.8%, 45.0%, and 47.9% of metastatic CRC samples, respectively. The 5-year overall survival rates associated with immune molecule-positive groups were significantly better than in the negative groups (PD-1: 87.7% vs 53.2%, p = 0.023; PD-L1: 82.4% vs 42.3%, p = 0.007; IDO: 80.7% vs 43.5%, p = 0.007; TAMs: 82.6% vs 48.0%, p = 0.005). Multivariate analysis revealed PD-1 expression (p = 0.032, hazard ratio: 0.19), IDO expression (p = 0.049, hazard ratio: 0.37), and tumor differentiation (p<0.001, hazard ratio: 0.02) as independent prognostic indicators. PD-1 and TAMs in metastases were associated with less aggressive features such as smaller tumors. Furthermore, TAMs positively and significantly correlated with PD-1 expression (p = 0.011), PD-L1 expression (p = 0.024), and tended to correlate with IDO expression (p = 0.078). PD-1, PD-L1, IDO, and TAMs in CRLM were associated with less aggressive features and better prognosis of patients with CRC, indicating adaptive antitumor immunity vs immune tolerance. These molecules may therefore serve as prognostic markers for CRLM. (キーワード) Adaptive Immunity / Adult / Aged / Aged, 80 and over / Antigens, CD / Antigens, Differentiation, Myelomonocytic / B7-H1 Antigen / Biomarkers, Tumor / Colonic Neoplasms / Colorectal Neoplasms / Diagnostic Tests, Routine / Female / Gene Expression / Humans / Immune Tolerance / Indoleamine-Pyrrole 2,3,-Dioxygenase / Japan / Liver / Liver Neoplasms / Male / Middle Aged / Neoplasm Metastasis / Prognosis / Programmed Cell Death 1 Receptor / Receptors, Cell Surface / Rectal Neoplasms / Transcriptome / Tumor-Associated Macrophages (徳島大学機関リポジトリ) ● Metadata: 117381 (出版サイトへのリンク) ● Publication site (DOI): 10.1371/journal.pone.0259940 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34797860 ● Search Scopus @ Elsevier (PMID): 34797860 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0259940 (徳島大学機関リポジトリ: 117381, DOI: 10.1371/journal.pone.0259940, PubMed: 34797860)
41.	Luping Gao, Yuji Morine, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Kazunori Tokuda, Chie Takasu, Katsuki Miyazaki and Mitsuo Shimada : Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells., PLoS ONE, Vol.16, No.9, e0256755, 2021. (要約) As a multiple tyrosine kinase inhibitor, sorafenib is widely used to treat hepatocellular carcinoma (HCC), but patients frequently face resistance problems. Because the mechanism controlling sorafenib-resistance is not well understood, this study focused on the connection between tumor characteristics and the Nrf2 signaling pathway in a sorafenib-resistant HCC cell line. A sorafenib-resistant HCC cell line (Huh7) was developed by increasing the dose of sorafenib in the culture medium until the target concentration was reached. Cell morphology, migration/invasion rates, and expression of stemness-related and ATP-binding cassette (ABC) transporter genes were compared between sorafenib-resistant Huh7 cells and parental Huh7 cells. Next, a small interfering RNA was used to knock down Nrf2 expression in sorafenib-resistant Huh7 cells, after which cell viability, stemness, migration, and ABC transporter gene expression were examined again. Proliferation, migration, and invasion rates of sorafenib-resistant Huh7 cells were significantly increased relative to the parental cells with or without sorafenib added to the medium. The expression levels of stemness markers and ABC transporter genes were up-regulated in sorafenib-resistant cells. After Nrf2 was knocked down in sorafenib-resistant cells, cell migration and invasion rates were reduced, and expression levels of stemness markers and ABC transporter genes were reduced. Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant HCC cells. (キーワード) ATP-Binding Cassette Transporters / Antineoplastic Agents / Carcinoma, Hepatocellular / Cell Line, Tumor / Cell Movement / Cell Proliferation / Cell Survival / Drug Resistance, Neoplasm / Gene Expression / Gene Expression Regulation, Neoplastic / Gene Knockdown Techniques / Humans / Liver Neoplasms / NF-E2-Related Factor 2 / Protein Kinase Inhibitors / Signal Transduction / Sorafenib / Transfection (徳島大学機関リポジトリ) ● Metadata: 117382 (出版サイトへのリンク) ● Publication site (DOI): 10.1371/journal.pone.0256755 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34473785 ● Search Scopus @ Elsevier (PMID): 34473785 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0256755 (徳島大学機関リポジトリ: 117382, DOI: 10.1371/journal.pone.0256755, PubMed: 34473785)
42.	Luping Gao, Yuji Morine, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Kazunori Tokuda, Katsuki Miyazaki, Shouhei Okikawa, Chie Takasu and Mitsuo Shimada : The BAFF/NF B axis is crucial to interactions between sorafenib-resistant HCC cells and cancer-associated fibroblasts., Cancer Science, Vol.112, No.9, 3545-3554, 2021. (要約) The tumor microenvironment affects malignancy in hepatocellular carcinoma (HCC) cells, and cancer-associated fibroblasts (CAFs) play an important role in the microenvironment. As recent studies indicated a difference between CAFs isolated from chemoresistant and non-resistant cancer tissues, therefore we investigated the intracellular mechanism in resistant HCC co-cultured CAFs and interactions between these CAFs with cancer cells. We established a sorafenib-resistant (SR) Huh7 (human HCC) cell line, and characterized it with cytokine assays, then developed CAFs by co-culturing human hepatic stellate cells with resistant or parental Huh7 cells. The 2 types of CAFs were co-cultured with parental Huh7 cells, thereafter the cell viability of these Huh7 cells was checked under sorafenib treatment. The SR Huh7 (Huh7 ) cells expressed increased B-cell activating factor (BAFF), which promoted high expression of CAF-specific markers in Huh7 -co-cultured CAFs, showed activated BAFF, BAFF-R, and downstream of the NF B-Nrf2 pathway, and aggravated invasion, migration, and drug resistance in co-cultured Huh7 cells. When we knocked down BAFF expression in Huh7 cells, the previously increased malignancy and BAFF/NF B axis in Huh7 -co-cultured CAFs reversed, and enhanced chemoresistance in co-cultured Huh7 cells returned as well. In conclusion, the BAFF/NF B pathway was activated in CAFs co-cultured with cell-culture medium from resistant Huh7, which promoted chemoresistance, and increased the malignancy in co-cultured non-resistant Huh7 cells. This suggests that the BAFF/NF B axis in CAFs might be a potential therapeutic target in chemoresistance of HCC. (キーワード) Antineoplastic Agents / B-Cell Activating Factor / Cancer-Associated Fibroblasts / Carcinoma, Hepatocellular / Cell Communication / Cell Line, Tumor / Cell Movement / Cell Survival / Coculture Techniques / Drug Resistance, Neoplasm / Gene Knockdown Techniques / Humans / Liver Neoplasms / NF-kappa B / Signal Transduction / Sorafenib / Transfection (徳島大学機関リポジトリ) ● Metadata: 116388 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/cas.15041 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34159680 ● Search Scopus @ Elsevier (PMID): 34159680 ● Search Scopus @ Elsevier (DOI): 10.1111/cas.15041 (徳島大学機関リポジトリ: 116388, DOI: 10.1111/cas.15041, PubMed: 34159680)
43.	Takuya Tokunaga, Hideya Kashihara, Jun Higashijima, Kouzou Yoshikawa, Masaaki Nishi, Chie Takasu, Shohei Eto, Toshiaki Yoshimoto and Mitsuo Shimada : A Transabdominal Robotic Purse-String Suture Technique for Transanal Total Mesorectal Excision., Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A, Vol.31, No.8, 937-941, 2021. (要約) Transanal total mesorectal excision (TaTME) is a novel technique that overcomes the problem of access to the deep pelvis during radical surgery for mid-rectal and lower rectal cancer. Although TaTME has several important steps, the creation of the distal purse-string suture following TaTME plays an important role in ensuring the integrity of the colorectal anastomosis. However, this procedure represents a major technical challenge for the surgeon. Robot-assisted surgery may make this suturing procedure easier than laparoscopic surgery because it permits intuitive wrist movements and a three-dimensional view. The aim of the present study was to investigate the usefulness of transabdominal robotic purse-string suture during anastomosis in TaTME. Twenty-seven patients, who underwent anastomosis using a single stapling technique (SST) during the TaTME of mid-rectal or lower rectal cancer, were enrolled in the study. The patients were allocated to two groups: 11 patients underwent transabdominal robotic purse-string suturing (the Robot group) and 16 patients underwent transanal purse-string suturing (the Transanal group). The characteristics and short-term surgical outcomes of the participants were compared between the two groups. The Robot group tended to have a shorter purse-string suturing time (541 206 seconds versus 729 310 seconds; = .07). Regarding the shape of the "donut" after SST anastomosis, in the Transanal group, 5 of the 16 participants had incomplete donuts with muscular defects and required additional suturing, whereas in the Robot group, all the participants had complete donuts ( = .04). Transabdominal robotic purse-string suturing may facilitate the suturing procedure and contribute to reliable anastomosis. (キーワード) Humans / Laparoscopy / Rectal Neoplasms / Rectum / Robotic Surgical Procedures / Robotics / Suture Techniques / Transanal Endoscopic Surgery (出版サイトへのリンク) ● Publication site (DOI): 10.1089/lap.2021.0286 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34242512 ● Search Scopus @ Elsevier (PMID): 34242512 ● Search Scopus @ Elsevier (DOI): 10.1089/lap.2021.0286 (DOI: 10.1089/lap.2021.0286, PubMed: 34242512)
44.	Masaaki Nishi, Mitsuo Shimada, Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa, Hideya Kashihara, Chie Takasu, Daichi Ishikawa, Yuuma Wada, Shohei Eto and Toshiaki Yoshimoto : Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer., World Journal of Surgical Oncology, Vol.19, No.1, 201, 2021. (要約) The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of systemic inflammation and host-tumor cell interactions. The aim of this study was to investigate the prognostic significance of LCR in lower rectal cancer patients who received preoperative chemo-radiotherapy (CRT). Forty-eight patients with lower rectal cancer who underwent CRT followed by curative surgery were enrolled in this study. Routine blood examinations were performed before and after CRT were used to calculate pre-CRT LCR and post-CRT LCR. The median LCR was used to stratify patients into low and high LCR groups for analysis. The correlation between pre- and post-CRT LCR and clinical outcomes was retrospectively investigated. The pre-CRT LCR was significantly higher than the post-CRT LCR (11,765 and 6780, respectively, P < 0.05). The 5-year overall survival rate was significantly higher for patients with high post-CRT LCR compared with low post-CRT LCR (90.6% and 65.5%, respectively, P < 0.05). In univariate analysis, post-CRT LCR, post-CRT neutrophil to lymphocyte ratio, and fStage were significant prognostic factors for overall survival. In multivariate analysis, post-CRT LCR, but not other clinicopathological factors or prognostic indexes, was a significant prognostic factor for overall survival (P < 0.05). Post-CRT LCR could be a prognostic biomarker for patients with lower rectal cancer. (キーワード) C-Reactive Protein / Chemoradiotherapy / Humans / Lymphocytes / Neoplasm Staging / Prognosis / Rectal Neoplasms / Retrospective Studies (徳島大学機関リポジトリ) ● Metadata: 117394 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12957-021-02319-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34229704 ● Search Scopus @ Elsevier (PMID): 34229704 ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-021-02319-x (徳島大学機関リポジトリ: 117394, DOI: 10.1186/s12957-021-02319-x, PubMed: 34229704)
45.	Jun Higashijima, Toru Kono, Mitsuo Shimada, Hideya Kashihara, Chie Takasu, Masaaki Nishi, Takuya Tokunaga, Ayumu Sugitani and Kouzou Yoshikawa : Intestinal hypoperfusion in patients with Crohn's disease revealed by intraoperative indocyanine green fluorescence imaging., Annals of Medicine and Surgery, Vol.66, 102402, 2021. (要約) Anastomotic leakage has been reported as an independent risk factor for surgical recurrence at the anastomotic site in patients with Crohn's disease. An inadequate blood supply may contribute to this leakage. Real-time indocyanine green angiography has been useful for confirming vascular perfusion of the intestines. The aim of this study was to evaluate the use of intraoperative indocyanine green angiography to detect vascular perfusion of the intestines during ileocaecal resection in patients with Crohn's disease and colon cancer. We retrospectively evaluated the medical records of 26 consecutive patients with colon cancer arising in the caecum or ascending colon and 3 consecutive patients with Crohn's disease without a history of disease-related surgery. The patients in the 2 cohorts had undergone ileocaecal resection at Tokushima University Hospital between January 2018 and January 2021. After ileocaecal resection, blood flow was evaluated in ileal (oral) and colon (anal) stapled stumps by indocyanine green fluorescence angiography. The fluorescence time was defined as the time from indocyanine green injection and flush of the injection route to the point when the stump showed the strongest fluorescent signal in the monitor. The fluorescence time for the ileal and colon stumps in patients with Crohn's disease was 43.3 8.8 s each and was significantly longer than the fluorescence time in the patients with colon cancer (29.4 6.5 s and 29.6 6.8 s, respectively) (P < 0.05). Intraoperative indocyanine green fluorescence imaging is safe and reproducible for assessing intestinal perfusion prior to anastomosis in patients with colon cancer and Crohn's disease. (徳島大学機関リポジトリ) ● Metadata: 117278 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.amsu.2021.102402 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34136203 ● Search Scopus @ Elsevier (PMID): 34136203 ● Search Scopus @ Elsevier (DOI): 10.1016/j.amsu.2021.102402 (徳島大学機関リポジトリ: 117278, DOI: 10.1016/j.amsu.2021.102402, PubMed: 34136203)
46.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Toshiaki Yoshimoto : The influence and countermeasure of obesity in laparoscopic colorectal resection., Annals of Gastroenterological Surgery, Vol.5, No.5, 677-682, 2021. (要約) The aim of this study was to investigate the influence of obesity and the usefulness of a preoperative weight loss program (PWLP) for obese patients undergoing laparoscopic colorectal resection (LCR). Study 1: 392 patients who underwent LCR for colorectal cancer were divided into two groups: those with a body mass index (BMI) ·25 kg/m (n = 113) and those with a BMI <25 kg/m (n = 279). The influence of BMI on LCR was investigated. Study 2: Patients with a BMI ·28 kg/m who were scheduled to undergo LCR (n = 7, mean body weight 87.0 kg, mean BMI 33.9 kg/m) undertook a PWLP including caloric restriction and exercise for 29.6 (15-70) days. The effects of this program were evaluated. Study 1: The BMI ·25 kg/m group had a prolongation of operation time and hospital stay than the BMI <25 kg/m group. Study 2: The patients achieved a mean weight loss of 6.9% (-6.0 kg). The mean visceral fat area was significantly decreased by 18.0%, whereas the skeletal muscle mass was unaffected. The PWLP group had a significantly lower prevalence of postoperative complications compared with the BMI ·25 kg/m group. Obesity affected the surgical outcomes in LCR. A PWLP may be useful for obese patients undergoing LCR. (徳島大学機関リポジトリ) ● Metadata: 117274 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/ags3.12455 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34585052 ● Search Scopus @ Elsevier (PMID): 34585052 ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12455 (徳島大学機関リポジトリ: 117274, DOI: 10.1002/ags3.12455, PubMed: 34585052)
47.	Chie Takasu, Katsuki Miyazaki, Kouzou Yoshikawa, Masaaki Nishi, Takuya Tokunaga, Hideya Kashihara, Toshiaki Yoshimoto, Hirohisa Ogawa, Yuji Morine and Mitsuo Shimada : Effect of TU-100 on Peyer's patches in a bacterial translocation rat model., Annals of Gastroenterological Surgery, Vol.5, No.5, 683-691, 2021. (要約) Daikenchuto (TU-100), a Japanese herbal medicine, is widely used for various gastrointestinal diseases. We have previously reported that TU-100 suppresses CPT-11-induced bacterial translocation (BT) by maintaining the diversity of the microbiome. In this study we show that TU-100 modulates the immune response during BT by inducing PD-1 expression in Peyer's patches. Eighteen male Wistar rats were divided into four groups: a control group; a control + TU-100 group, given TU-100 1000 mg/kg orally for 5 d; a BT group, given CPT-11 250 mg/kg intra-peritoneal for 2 d; and a TU-100 group, given TU-100 1000 mg/kg orally for 5 d with CPT-11 250 mg/kg intra-peritoneal on days 4 and 5. The size of Peyer's patch was significantly bigger in the BT group compared to the control group (9.0 104 m vs 29.4 104 m, < .05), but improved in the TU-100 group (15.4 104 m, < .005). TU-100 significantly induced PD-1 expression in Peyer's patch compared to the control group and the BT group (control vs BT vs TU-100 = 4.3 4.9 vs 5.1 10.3 vs 17.9 17.8). The CD4 cells were increased in the BT group ( < .05) compared to the control group but decreased in the TU-100 group. The Foxp3 cells were increased in the BT group compared to the control group ( < .05), and further increased in the TU-100 group compared to the BT group. CPT-11 significantly increased TLR4, NF- , TNF- mRNA expressions in the BT group. TU-100 cotreatment significantly reversed these mRNA expressions. TU-100 may have a protective effect against BT through PD-1 expression in Peyer's patch. (徳島大学機関リポジトリ) ● Metadata: 117275 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/ags3.12460 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34585053 ● Search Scopus @ Elsevier (PMID): 34585053 ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12460 (徳島大学機関リポジトリ: 117275, DOI: 10.1002/ags3.12460, PubMed: 34585053)
48.	Toshiaki Yoshimoto, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Chiharu Nakasu and Mitsuo Shimada : Robotic-assisted total gastrectomy in a patient with gastric cancer associated with situs inversus totalis: With video., Asian Journal of Endoscopic Surgery, Vol.14, No.2, 297-300, 2021. (要約) Situs inversus totalis (SIT) refers to an inverted position of the major visceral organ as a "mirror image" of the regular location. We present a video of a robotic-assisted total gastrectomy in a 84-year-old man with SIT. The patient was diagnosed with advanced gastric cancer in the U region. The port placement was done as mirror images of our usual settings. Lymph node dissection was performed with a completely reverse approach to the usual procedure. After total gastrectomy, an intracorporal esophagojejunostomy was performed by circular method. All procedures were performed safely with no intraoperative complications and the patient was discharged uneventfully. Pathological diagnosis confirmed moderately differentiated adenocarcinoma and the depth of invasion was to the subserosa; there were five metastatic lymph nodes. In patients who have gastric cancer with SIT, a robotic-assisted total gastrectomy can be performed safely without surgical complication. Robots are useful for performing a total gastrectomy in SIT. (出版サイトへのリンク) ● Publication site (DOI): 10.1111/ases.12860 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32875706 ● Search Scopus @ Elsevier (PMID): 32875706 ● Search Scopus @ Elsevier (DOI): 10.1111/ases.12860 (DOI: 10.1111/ases.12860, PubMed: 32875706)
49.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Toshiaki Yoshimoto : Pre-operative Weight Loss Program for Obese Patients Undergoing Laparoscopic Gastrectomy., The Journal of Medical Investigation : JMI, Vol.68, No.1.2, 165-169, 2021. (要約) Background : The aim of this study was to investigate the influence of obesity and the usefulness of a pre-operative weight loss program (PWLP) for obese patients undergoing laparoscopic gastrectomy (LG) for gastric cancer (GC). Materials and Methods : Study1 : 219 patients who underwent laparoscopic distal gastrectomy (LDG) for GC were divided into 2 groups : body mass index (BMI) 28 and BMI < 28kg /2. The influence of BMI in LG surgery was investigated. Study2 : The BMI 28 kg /2 patients with a planned LG (n = 8) undertook a PWLP including calorie restriction and exercise. The effects of this program were evaluated. Results : Study1 : The BMI 28kg /2 group showed significantly longer operation times, more blood loss and a higher frequency of post-operative complications than that of the BMI < 28kg /2 group. Study 2 : The patients achieved a weight loss of 4.2%. The visceral fat area (VFA) was significantly decreased by 10.6%, whereas skeletal muscle mass was unaffected. The PWLP group showed shorter operation times, less blood loss and a lower frequency of post-operative complications compared with that of the BMI 28kg /2 group. Conclusion : Obesity is an important risk factor and a pre-operative weight loss program is useful for obese patients undergoing a LG. J. Med. Invest. 68 : 165-169, February, 2021. (徳島大学機関リポジトリ) ● Metadata: 116007 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.68.165 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33994464 ● Search Scopus @ Elsevier (PMID): 33994464 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.165 (徳島大学機関リポジトリ: 116007, DOI: 10.2152/jmi.68.165, PubMed: 33994464)
50.	Jun Higashijima, Takuya Tokunaga, Toshiaki Yoshimoto, Shohei Eto, Hideya Kashihara, Chie Takasu, Masaaki Nishi, Kouzou Yoshikawa, Hiroshi Okitsu, Masashi Ishikawa, Hidenori Miyake, Toshiyuki Yagi, Toru Kono and Mitsuo Shimada : A multicenter phase II trial of preoperative chemoradiotherapy with S-1 plus oxaliplatin and bevacizumab for locally advanced rectal cancer., International Journal of Clinical Oncology, Vol.26, No.5, 875-882, 2021. (要約) We clarified the safety and efficacy of preoperative chemoradiotherapy for locally advanced rectal cancer using a multidrug regimen (S-1 +xaliplatin +evacizumab). This multicenter phase II trial involved 47 patients with locally advanced rectal cancer. All patients received S-1 orally (80 mg/m/day on days 1-5, 8-12, 15-19, and 22-26) and infusions of oxaliplatin (50 mg/m on days 1, 8, 15, and 22) and bevacizumab (5 mg/kg on days 1 and 15). The total radiation dose was 40 Gy delivered in daily fractions of 2 Gy via the four-field technique. The primary endpoint was the pathological complete response rate. The secondary endpoints were safety (incidence of adverse events) and clinical response, relapse-free survival, overall survival, local recurrence, R0 resection, downstaging, and treatment completion rates. All 47 patients received chemoradiotherapy, and 44 patients underwent curative resection. Two patients refused surgery and selected a watch-and-wait strategy. The pathological complete response rate was 18.2% in patients who underwent curative resection. The clinical response rate was 91.3% in 46 patients. Concerning hematotoxicity, there was one grade 4 adverse event (2.1%) and seven grade 3 events (14.9%). Diarrhea was the most frequent non-hematotoxic event, and the grade 3 event rate was 25.5%. Although preoperative chemoradiotherapy for patients with locally advanced rectal cancer using the S-1 +xaliplatin +evacizumab regimen did not achieve the expected pathological complete response rate, this regimen led to an improved clinical response rate. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10147-021-01868-1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33486623 ● Search Scopus @ Elsevier (PMID): 33486623 ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-021-01868-1 (DOI: 10.1007/s10147-021-01868-1, PubMed: 33486623)
51.	Shoko Yamashita, Masaaki Nishi, Tetsuya Ikemoto, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Shohei Eto, Toshiaki Yoshimoto and Mitsuo Shimada : Clinical analysis of postoperative venous thromboembolism in Japanese patients after colorectal cancer surgery., Surgery Today, Vol.51, No.6, 1022-1027, 2021. (要約) Venous thromboembolism (VTE) is a major complication after abdominal surgery; however, the best strategy for preventing VTE after surgery is not yet established. We performed this study to investigate the incidence of perioperative VTE and evaluate the efficacy of a VTE preventive strategy for patients undergoing surgery for colorectal cancer (CRC). The subjects of this retrospective analysis were 228 patients who underwent curative surgical resection for CRC between 2012 and 2016. The patients were treated with thromboprophylaxis including enoxaparin. We assessed the perioperative VTE occurrence rate and investigated the risk factors for postoperative VTE. Among the 228 patients, 77 had a preoperative D-dimer level of > 1.0 g/mL and 12 had deep vein thrombosis (DVT) diagnosed by ultrasonography preoperatively. Of the remaining 216 patients, short-term VTE (< 30 days) developed in two patients (0.9%) and long-term VTE (30 days-3 years) developed in seven (3.2%). The mortality rate of patients with VTE was 0%. The univariate analysis indicated that pulmonary disease was the risk factor for short-term VTE, whereas obesity, hyperlipidemia, and a preoperative history of pulmonary embolism were the risk factors for long-term VTE (p < 0.05). The findings of this analysis show that our preventive protocol including enoxaparin is an effective strategy for preventing postoperative VTE. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00595-020-02201-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33387025 ● Search Scopus @ Elsevier (PMID): 33387025 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-020-02201-5 (DOI: 10.1007/s00595-020-02201-5, PubMed: 33387025)
52.	Shohei Okikawa, Jun Higashijima, Masaaki Nishi, Toshiaki Yoshimoto, Shohei Eto, Chie Takasu, Hideya Kashihara, Takuya Tokunaga, Kouzou Yoshikawa and Mitsuo Shimada : SDF-1 expression after preoperative chemoradiotherapy is associated with prognosis in patients with advanced lower rectal cancer., The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 309-314, 2021. (要約) Stromal cell-derived factor-1 (SDF-1) expression is associated with cancer progression, as a biomarker of prognosis. We clarified the significance of SDF-1 expression on chemoradiotherapy (CRT) resistance and prognosis in advanced lower rectal cancer patients. We evaluated 98 patients with advanced lower rectal cancer who underwent preoperative CRT. All patients received 40 Gy of radiation therapy, with concurrent chemotherapy containing fluorinated pyrimidines, followed by surgical resection. SDF-1 expression in surgical specimens was examined by immunohistochemistry. We divided the patients into SDF-1-positive- (n = 52) and SDF-1-negative groups (n = 46) and compared the clinicopathological factors and survival rates. The SDF-1-positive group was more resistant to CRT than the SDF-1-negative group (non-responder rate, 63.5% vs. 47.8%, respectively ; p = 0.12). Overall survival (OS) in the SDF-1 positive group was significantly poorer vs. the SDF-1-negative group (5-year OS, 73.4% vs. 88.0%, respectively ; p = 0.02), and disease-free survival (DFS) was worse (5-year DFS, 61.0% vs. 74.1%, respectively ; p = 0.07). Multivariate analysis confirmed that SDF-1 expression was a significant independent prognostic predictor of OS (p = 0.04). SDF-1 expression after preoperative CRT is significantly associated with a poor prognosis in advanced lower rectal cancer patients and is a promising biomarker. J. Med. Invest. 68 : 309-314, August, 2021. (キーワード) Chemoradiotherapy / Disease-Free Survival / Humans / Neoplasm Staging / Prognosis / Rectal Neoplasms / Rectum (徳島大学機関リポジトリ) ● Metadata: 116500 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.68.309 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759150 ● Search Scopus @ Elsevier (PMID): 34759150 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.309 (徳島大学機関リポジトリ: 116500, DOI: 10.2152/jmi.68.309, PubMed: 34759150)
53.	Shohei Eto, Kouzou Yoshikawa, Yukako Takehara, Toshiaki Yoshimoto, Chie Takasu, Hideya Kashihara, Masaaki Nishi, Takuya Tokunaga, Toshihiro Nakao, Jun Higashijima, Takashi Iwata and Mitsuo Shimada : Usefulness of a multidisciplinary surgical site infection team in colorectal surgery., The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 256-259, 2021. (要約) Background : Surgical site infection (SSI) is an adverse event that places a major burden on patients and staff. In this study, we examined the occurrence of SSI and the characteristics of patients referred to the SSI team after colorectal surgery. Methods : In total, 955 patients underwent colorectal surgery at our hospital from 2014 to 2019. Of these 955 patients, 516 received therapeutic support by the SSI team from 2017 to 2019. All patients were evaluated using an SSI surveillance sheet, and we checked for reports of SSI once a month. Each attending physician performed SSI prophylaxis (use of new instruments before wound irrigation and closure). Results : SSI occurred in 80 (8.4%) patients. The incidence of SSI and the incidence of surface SSI were higher in the patients who did not receive intervention by the SSI team than in the patients who did. Organ /pace SSI occurred in 18 patients. Among patients with surface SSI, Enterococcus was the most commonly detected bacteria. Among the 18 patients with organ /pace SSI, 5 developed anastomotic leakage and 4 developed intra-abdominal abscesses. Conclusions : An SSI team for prevention and treatment of infection may contribute to reduction of SSI. J. Med. Invest. 68 : 256-259, August, 2021. (キーワード) Colorectal Surgery / Humans / Incidence / Risk Factors / Surgical Wound Infection / Therapeutic Irrigation (徳島大学機関リポジトリ) ● Metadata: 116491 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.68.256 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759140 ● Search Scopus @ Elsevier (PMID): 34759140 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.256 (徳島大学機関リポジトリ: 116491, DOI: 10.2152/jmi.68.256, PubMed: 34759140)
54.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Shohei Eto and Toshiaki Yoshimoto : Impact of CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) expression in gastric cancer., The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 362-367, 2021. (要約) Background : CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) is the master regulator of programmed cell death-ligand 1 (PD-L1). We aimed to clarify the significance of CMTM6 expression in gastric cancer (GC). Methods : A total of 105 patients who had undergone curative surgical resection for stage II /II GC at Tokushima University Hospital were included in this study. The expression of CMTM6 was examined by immunohistochemistry. Additionally, the relationship of each expression level to several prognostic factors was examined using univariate and multivariate analyses. Results : CMTM6 was not positively correlated with any of the factors examined. The overall survival (OS) rates were significantly poorer in the CMTM6 high-expression group than in the CMTM low-expression group (5-year OS : 57.2% vs. 79.2%, respectively ; p < 0.05). Disease-free survival (DFS) was significantly poorer in the CMTM high-expression group than in the CMTM6 low-expression group (5-year DFS : 52.8% vs. 72.4%, respectively ; p < 0.05). Multivariate analysis confirmed CMTM6 expression as an independent prognostic factor in DFS (p < 0.05). CMTM6 expression tended to be correlated with PD-L1 expression (p = 0.07). Conclusions : CMTM6 is associated with a poor prognosis and immunotolerance through PD-L1 in GC. J. Med. Invest. 68 : 362-367, August, 2021. (キーワード) B7-H1 Antigen / Chemokines / Humans / MARVEL Domain-Containing Proteins / Myelin Proteins / Prognosis / Stomach Neoplasms / Survival Rate (徳島大学機関リポジトリ) ● Metadata: 116552 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.68.362 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759159 ● Search Scopus @ Elsevier (PMID): 34759159 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.362 (徳島大学機関リポジトリ: 116552, DOI: 10.2152/jmi.68.362, PubMed: 34759159)
55.	髙須千絵, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 徳永卓哉, 柏原秀也, 武原悠花子 : 夢を実現し，輝く女性外科医たち-求められるサポート体制と働き方改革- 地方外科から発信するダイバーシティ・インクルージョンを目指した取り組み, 日本外科学会雑誌, Vol.121, No.6, 692-693, 2020年. (キーワード) 労働衛生女性医師病院人事管理文化の多様性ワークライフバランス外科医ヒト女
56.	Chie Takasu, Masaaki Nishi, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada : Impact of sidedness of colorectal cancer on tumor immunity., PLoS ONE, Vol.15, No.10, e0240408, 2020. (要約) Clinical and molecular characteristics differ between right-sided and left-sided colorectal cancer (CRC). This study aimed to clarify the correlation between CRC sidedness and tumor immunity. A total of 102 patients who underwent curative colectomy for stage II/III CRC were included in this study. The expression of programmed cell death (PD)-1, PD1-ligand 1 (PD-L1), forkhead box P3 (Foxp3), transforming growth factor (TGF)-β, and indoleamine-pyrrole 2,3-dioxygenase (IDO) were examined using immunohistochemistry and the relationships between sidedness and several prognostic factors were examined. Clinicopathological factors were not significantly different between right- and left-sided CRC. The tumor immunity-related molecule PD-L1 was more highly expressed in right-sided than in left-sided CRC (62.9% vs. 30.6%, p<0.01). No significant difference was found in overall survival (OS) and disease-free survival (DFS) by sidedness. PD-1 and Foxp3 expression were significant prognostic factors for OS. Lymph node metastasis (N), lymphatic invasion (ly), and PD-L1 expression were significant prognostic factors for DFS. In right-sided CRC, IDO-positive patients had a poor OS (p<0.05), and IDO was the only independent prognostic indicator for OS. N and venous invasion were identified as independent prognostic indicators for DFS. In left-sided CRC, univariate analysis identified PD-1, PD-L1, and Foxp3 expression as significant predictors of poor OS. Multivariate analysis confirmed PD-L1 expression as an independent prognostic indicator. N, ly, and PD-L1 expression levels were identified as significant predictors of poor DFS. The prognostic factors were IDO in right-sided CRC and PD-L1 and Foxp3 in left-sided CRC. These findings indicated that tumor immunity might play different roles depending upon sidedness. Tumor location may be an important factor to consider when assessing immune response and therapeutic decisions in CRC patients. (キーワード) Adult / Aged / Aged, 80 and over / B7-H1 Antigen / Biomarkers, Tumor / Colorectal Neoplasms / Disease-Free Survival / Female / Forkhead Transcription Factors / Gene Expression Regulation, Neoplastic / Humans / Indoleamine-Pyrrole 2,3,-Dioxygenase / Male / Middle Aged / Neoplasm Staging / Prognosis / Programmed Cell Death 1 Receptor / Transforming Growth Factor beta / Up-Regulation (徳島大学機関リポジトリ) ● Metadata: 115400 (出版サイトへのリンク) ● Publication site (DOI): 10.1371/journal.pone.0240408 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33045001 ● Search Scopus @ Elsevier (PMID): 33045001 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0240408 (徳島大学機関リポジトリ: 115400, DOI: 10.1371/journal.pone.0240408, PubMed: 33045001)
57.	Yuuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Shin-ichiro Yamada and Mitsuo Shimada : HIF-1 expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis., World Journal of Surgical Oncology, Vol.18, No.1, 241, 2020. (要約) The role of hypoxia-inducible factor-1 (HIF-1 ) in primary colorectal cancer (CRC) and colorectal liver metastasis (CRLM) has remained unclear. The aim of this study was to investigate HIF-1 expression and its association with prognosis in patients with CRLM with a focus on hepatic stellate cells (HSCs). Colon cancer cells were cultured in HSC-conditioned medium (CM), and HIF-1 expression and cell migration were analyzed. Seventy-five patients with CRLM who underwent an initial curative hepatectomy were enrolled. We examined HIF-1 expressions and patient prognosis between primary CRCs and the matched liver metastatic specimens. Activated HSCs induced HIF-1 mRNA and protein expression in colon cancer cells (p < 0.01) and promoted cell migration (p < 0.01). The positive rates of HIF-1 expression in primary CRCs and liver metastases were 68.0 and 72.0%, respectively. There were no differences in overall (OS) and disease-free survival (DFS) of HIF-1 expression in primary CRC. However, HIF-1 expression in liver metastasis correlated to poor prognosis in both OS and DFS. Furthermore, patients with HIF-1 positive expression in liver metastasis had poor prognosis. HIF-1 expression in liver metastasis determines poor prognosis of CRLM patients. HSCs might play a key role in aggressive phenotypes of tumor cells. (キーワード) Colonic Neoplasms / Colorectal Neoplasms / Humans / Hypoxia-Inducible Factor 1, alpha Subunit / Liver Neoplasms / Prognosis (徳島大学機関リポジトリ) ● Metadata: 116676 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12957-020-02012-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32895059 ● Search Scopus @ Elsevier (PMID): 32895059 ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-020-02012-5 (徳島大学機関リポジトリ: 116676, DOI: 10.1186/s12957-020-02012-5, PubMed: 32895059)
58.	Shogo Oota, Masaaki Nishi, Takuya Tokunaga, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Hideya Kashihara, Chie Takasu, Daichi Ishikawa and Mitsuo Shimada : Usefulness of an ICG fluorescence catheter system in TaTME for avoiding intraoperative urethral injury., The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 285-288, 2020. (要約) Sometimes intraoperative urethral injury occurs in Transanal total mesorectal excision (TaTME). The aim of this study is to investigate the usefulness of indocyanine green (ICG) fluorescent catheter system for avoiding intraoperative urethral injury in TaTME in experimental model. A urethral catheter was filled with the mixture of albumin and ICG and raw hams were applied in layers as the surrogate model of rectourethral muscle. The detectability of ICG fluorescence in this catheter was investigated by using laparoscope-type fluorescence camera system. Fluorescence was detected when ICG was mixed with albumin or peripheral blood. ICG fluorescence could be detected within 4 mm depth of layered raw hams as the surrogate model. Quantitative analysis of the picture detected that ICG fluorescence plateaued in lower concentration than that of serum. ICG fluorescent catheter system may be useful for avoiding intraoperative urethral injury in TaTME. J. Med. Invest. 67 : 285-288, August, 2020. (徳島大学機関リポジトリ) ● Metadata: 115426 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.285 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148903 ● Search Scopus @ Elsevier (PMID): 33148903 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.285 (徳島大学機関リポジトリ: 115426, DOI: 10.2152/jmi.67.285, PubMed: 33148903)
59.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Toshiaki Yoshimoto : Trans-abdominal Pre-peritoneal (TAPP) Inguinal Hernia Repair with Liquid-injection and Gauze Dissection., The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 271-273, 2020. (要約) Purpose : This report describes a novel technique for trans-abdominal pre-peritoneal (TAPP) inguinal hernia repair using liquid injection and gauze dissection. Methods : Twenty-five cases underwent TAPP inguinal hernia repair with liquid-injection and gauze dissection. Before the initial peritoneal incision, liquid injection was performed percutaneously into the pre-peritoneal space at the outside of the internal inguinal ring and the inside of the seminal duct. Especially, at the inside of the seminal duct, the liquid was injected into the space between the superficial and deep lobe of pre-peritoneal fascia. Gauze was effectively used to dissect this liquid-injected space. Results : In comparison with the cases of inguinal hernia repair without liquid-injection and gauze dissection, the cases who underwent TAPP inguinal hernia repair with liquid-injection and gauze dissection experienced shorter operation times and no complications or recurrence. Conclusions : TAPP inguinal hernia repair with liquid-injection and gauze dissection appears to be a safe and feasible procedure. J. Med. Invest. 67 : 271-273, August, 2020. (徳島大学機関リポジトリ) ● Metadata: 115423 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.271 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148900 ● Search Scopus @ Elsevier (PMID): 33148900 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.271 (徳島大学機関リポジトリ: 115423, DOI: 10.2152/jmi.67.271, PubMed: 33148900)
60.	Yukako Takehara, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada : Desmoid-type fibromatosis difficult to distinguish from GIST : A case report., The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 375-377, 2020. (要約) Background : Desmoid-type fibromatosis is a very rare disease that has no characteristic image findings, so it is often difficult to differentiate from gastrointestinal stromal tumor (GIST). A case of desmoid-type fibromatosis that was difficult to differentiate from GIST is reported. The decisive factor in the diagnosis was positive nuclear immunostaining for β-catenin nucleus. Case presentation : A man is his 30s had no significant past medical history, including no abdominal surgery. A medical check-up found a large tumor in the right lateral abdomen. After some examinations, a preoperative diagnosis of GIST was made, and open ileocecal resection was performed. However, the final diagnosis based on the pathological findings was desmoid-type fibromatosis. Conclusions : We should consider desmoid-type fibromatosis when we find a large abdominal mass, but it may be difficult to diagnose based only on imaging findings. Immunohistochemical examination of the specimen may make the diagnosis. J. Med. Invest. 67 : 375-377, August, 2020. (徳島大学機関リポジトリ) ● Metadata: 115460 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.375 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148921 ● Search Scopus @ Elsevier (PMID): 33148921 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.375 (徳島大学機関リポジトリ: 115460, DOI: 10.2152/jmi.67.375, PubMed: 33148921)
61.	Hiroki Teraoku, Yuji Morine, Naoto Uyama, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Satoru Imura, Masafumi Harada and Mitsuo Shimada : Role of Central Hypo-enhancement in the Hepatic Arterial Phase of Dynamic Computed Tomography in Patients with Mass-Forming Intrahepatic Cholangiocarcinoma., World Journal of Surgery, Vol.44, No.7, 2350-2358, 2020. (要約) The enhancement pattern in the hepatic arterial phase (HAP) of dynamic computed tomography (CT) is reportedly a prognostic marker in patients with intrahepatic cholangiocarcinoma (IHCC). This study was performed to clarify the significance of central hypo-enhancement in the HAP in patients with mass-forming IHCC. Forty patients who had undergone initial surgical resection for mass-forming IHCC were enrolled. The dynamic CT was scanned 40 s after contrast agent injection as the HAP. A radiologist classified the patients into three groups based on the vascular pattern: the hyper-enhancement group (Hyper group), rim-enhancement group (Rim group), and hypo-enhancement group (Hypo group). The surgical specimens were immunohistochemically stained for hypoxia-inducible factor 1 (HIF-1). The correlation with clinicopathological findings and HIF-1 expression was investigated. The Hyper, Rim, and Hypo groups comprised 8, 7, and 25 patients, respectively. There were no significant correlations between the groups and clinicopathological factors. Overall survival (OS) was significantly worse in the Hypo than in the Hyper group (p = 0.03). OS was also significantly worse in the Rim +ypo group (i.e., hypo-enhancement in the central tumor) than in the Hyper group (p = 0.04). Furthermore, inclusion in the Rim +ypo group was a prognostic factor for OS (hazard ratio 6.68). High HIF-1 expression in the central part of the tumor was correlated with central hypo-enhancement (Hyper group: 25% and Rim +ypo group: 72%). Central hypo-enhancement was a prognostic factor in patients with IHCC. The high malignant potential of tumors with central hypo-enhancement might be associated with HIF-1 upregulation. (キーワード) Adult / Aged / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Biomarkers, Tumor / Cholangiocarcinoma / Contrast Media / Female / Follow-Up Studies / Hepatectomy / Hepatic Artery / Humans / Hypoxia-Inducible Factor 1, alpha Subunit / Male / Middle Aged / Multidetector Computed Tomography / Prognosis / Proportional Hazards Models / Retrospective Studies (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00268-020-05456-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32152739 ● Search Scopus @ Elsevier (PMID): 32152739 ● Search Scopus @ Elsevier (DOI): 10.1007/s00268-020-05456-8 (DOI: 10.1007/s00268-020-05456-8, PubMed: 32152739)
62.	Yuuma Wada, Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Daichi Ishikawa, Toshiaki Yoshimoto and Mitsuo Shimada : Usefulness of virtual three-dimensional image analysis in inguinal hernia as an educational tool., Surgical Endoscopy, Vol.34, No.2, 1923-1928, 2020. (要約) The pre-operative three-dimensional (3D) imaging technique has resulted in a better surgical outcome for patients and has been used as an education and diagnostic tool. However, there are no reports concerning the usefulness of the 3D imaging technique in laparoscopic transabdominal pre-peritoneal repair (TAPP) so the aim of this study was to investigate the usefulness of the 3D imaging technique in laparoscopic TAPP as an educational tool for medical students. Six (6) patients who underwent laparoscopic TAPP for inguinal hernia were enrolled in this study. 3D reconstruction was performed from pre-operative computed tomography (CT) and the usefulness of pre-operative 3D simulation compared with intra-operative laparoscopic imaging was validated. Moreover, thirty (30) medical students at the university completed a multiple-choice questionnaire (MCQ) to determine the level of their satisfaction and understanding of anatomy resulting from the study. The local anatomy of the patients was identified as the same during the operation as the pre-operative 3D simulation. The results of the MCQ showed that most of the medical students were extremely (23%) or very (67%) satisfied with the effect of pre-operative 3D simulation on the quality of the surgery. Moreover, most students could understand the surgery anatomy by the 3D simulation extremely well (40%) or very well (47%) and agreed on the usefulness of this procedure for learning anatomy. Pre-operative 3D simulation increases the understanding of detailed anatomy and virtual three-dimensional image analysis in laparoscopic TAPP is useful as an educational tool for medical students. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00464-019-06964-y (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31312962 ● Search Scopus @ Elsevier (PMID): 31312962 ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-019-06964-y (DOI: 10.1007/s00464-019-06964-y, PubMed: 31312962)
63.	柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 武原悠花子 : 【最先端医療を支える病理学】消化管最新外科手術における病理の役割, 四国医学雑誌, Vol.76, No.1-2, 3-8, 2020年. (キーワード) 胃腫瘍(外科的療法,病理学) 細胞診術中期生活の質直腸腫瘍(外科的療法) 保険適用範囲 *ロボット手術ヒト (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050566774761702016 (CiNii: 1050566774761702016)
64.	Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Mitsuo Shimada : The usefulness of intraoperative X-ray fluoroscopy in avoiding urethral injury during transanal total mesorectal excision., Asian Journal of Endoscopic Surgery, Vol.13, No.2, 242-245, 2020. (要約) Urethral injury is one of the most important complications that can occur during transanal total mesorectal excision in male patients with rectal cancer. This report shows the usefulness of intraoperative X-ray fluoroscopy to avoid urethral injury associated with transanal total mesorectal excision. Real-time navigation using fluoroscopy was performed to check the distance between the urethra and the dissection line at the level of the exposed rectourethral muscle, the middle level of the divided rectourethral muscle, and the level at which the prostate was identified. The dissection was completed transanally up to the level of peritoneal reflection on the anterior side without urethral injury. Pathological examination confirmed that the circumferential resection margin was tumor free. This novel technique using intraoperative X-ray fluoroscopy is an easy-to-use approach that helps prevent urethral injury in male patient who undergo transanal total mesorectal excision for rectal cancer. (出版サイトへのリンク) ● Publication site (DOI): 10.1111/ases.12717 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31215751 ● Summary page in Scopus @ Elsevier: 2-s2.0-85083042497 (DOI: 10.1111/ases.12717, PubMed: 31215751, Elsevier: Scopus)
65.	Daichi Ishikawa, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa and Mitsuo Shimada : The Role of Neutrophil-to-lymphocyte Ratio on the Effect of CRT for Patients With Rectal Cancer., In Vivo, Vol.34, No.2, 863-868, 2020. (要約) Neutrophil-to-lymphocyte ratio (NLR) is an indicator of systemic inflammation and could be a predictive factor in malignant tumors. The aim of this study was to investigate the impact of NLR in patients with lower rectal cancer who received preoperative chemo-radiotherapy (CRT). Forty-eight patients with lower rectal cancer who underwent preoperative CRT and curative resection were enrolled. Blood samples were obtained before and after CRT. The relationship of NLR with clinical outcome was investigated. Post-CRT NLR was higher compared to pre-CRT NLR. The patients with higher post-CRT NLR tended to have worse pathological response to CRT compared to those with low post-CRT NLR. The patients with high post-CRT NLR showed poorer 5-year overall survival and 3-year disease free survival while there was no correlation according to pre-CRT NLR. The univariate analysis showed that post-CRT stage and post-CRT NLR were associated with a poorer 5-year overall survival. NLR after preoperative CRT could be a potential prognostic indicator for patients with lower rectal cancer. (キーワード) Aged / Aged, 80 and over / Biomarkers, Tumor / Chemoradiotherapy / Combined Modality Therapy / Female / Humans / Leukocyte Count / Lymphocytes / Male / Middle Aged / Neoplasm Staging / Neutrophils / Preoperative Care / Prognosis / Rectal Neoplasms / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.21873/invivo.11850 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32111796 ● Search Scopus @ Elsevier (PMID): 32111796 ● Search Scopus @ Elsevier (DOI): 10.21873/invivo.11850 (DOI: 10.21873/invivo.11850, PubMed: 32111796)
66.	Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Chie Takasu, Jun Higashijima, Satoru Imura and Mitsuo Shimada : Clinical Impact of FOLFOXIRI Aiming for Conversion Surgery in Unresectable Multiple Colorectal Liver Metastasis., Anticancer Research, Vol.39, No.9, 5089-5096, 2019. (要約) We evaluated the clinical impact of FOLFOXIRI regimen aiming for conversion surgery in patients with unresectable multiple colorectal liver metastasis (CRLM). A total of 42 patients with unresectable multiple CRLM who received chemotherapy with molecular agents were included in the analysis. The clinical results of FOLFOXIRI with other regimens were compared. The total conversion rate of 42 unresectable CRLM was 48.1%, and conversion cases had a better prognosis. Clinicopathological characteristics of conversion cases were more frequent in FOLFOXIRI induction, liver limited disease and maximum diameter number (MDN) over 70. FOLFOXIRI achieved a higher conversion rate compared to other regimens (72.2% vs. 37.5%, p=0.0334), and significantly reduced the medication period until conversion surgery (median 5.8 courses) with a higher tumour necrotic rate. Consequently, the overall survival of conversion cases with FOLFOXIRI was better than that with other regimens (p=0.0055). FOLFOXIRI plus molecular agents might provide a higher probability of conversion surgery with a prognostic benefit. (キーワード) Antineoplastic Combined Chemotherapy Protocols / Camptothecin / Colorectal Neoplasms / Combined Modality Therapy / Conversion to Open Surgery / 女性 (female) / Fluorouracil / Hepatectomy / Humans / Kaplan-Meier Estimate / Leucovorin / Liver Neoplasms / 男性 (male) / Neoplasm Grading / Neoplasm Staging / Organoplatinum Compounds / Prognosis / Treatment Outcome / Tumor Burden (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.13703 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31519620 ● Search Scopus @ Elsevier (PMID): 31519620 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.13703 (DOI: 10.21873/anticanres.13703, PubMed: 31519620)
67.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi and Chie Takasu : Duodenal-Jejunal Bypass Maintains Gut Permeability by Suppressing Gut Inflammation., Obesity Surgery, Vol.29, No.9, 2745-2749, 2019. (要約) The aim of this study was to investigate gut inflammation and permeability in rats after duodenal-jejunal bypass (DJB) and in rats injected with a glucagon-like peptide-1 (GLP-1) receptor analog. Twelve male 16-week-old obese diabetic rats were divided into three groups: the DJB group, the sham group, and the group injected daily with a GLP-1 receptor agonist (liraglutide). Gut inflammation and the expression of tight junction protein (claudin-1) were analyzed in the three groups at 8 weeks after surgery. The DJB group showed significantly lower levels of gut inflammatory cytokines than the liraglutide group. Claudin-1 showed stronger intensity on immunofluorescent staining in the DJB group than that in the liraglutide group. In summary, DJB surgery might maintain gut permeability via suppression of gut inflammation. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s11695-019-03922-4 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31209833 ● Search Scopus @ Elsevier (PMID): 31209833 ● Search Scopus @ Elsevier (DOI): 10.1007/s11695-019-03922-4 (DOI: 10.1007/s11695-019-03922-4, PubMed: 31209833)
68.	岩橋祥子, 柏原秀也, 髙須千絵, 西正暁, 徳永卓哉, 宮谷知彦, 東島潤, 吉川幸造, 島田光生 : 骨髄異形成症候群・発作性夜間血色素尿症合併胃癌に対する腹腔鏡手術の1例, 日本外科系連合学会誌, Vol.44, No.4, 706-712, 2019年. (キーワード) Haptoglobins(治療的利用) (出版サイトへのリンク) ● Publication site (DOI): 10.4030/jjcs.44.706 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390848250139518080 ● Search Scopus @ Elsevier (DOI): 10.4030/jjcs.44.706 (DOI: 10.4030/jjcs.44.706, CiNii: 1390848250139518080)
69.	Shoko Iwahashi, Masaaki Nishi, Toshiaki Yoshimoto, Hideya Kashihara, Chie Takasu, Takuya Tokunaga, Tomohiko Miyatani, Jun Higashijima, Kouzou Yoshikawa, Yuuma Wada, Yoshimi Bando and Mitsuo Shimada : A case of gastric heterotopic pancreas with gastroduodenal invagination., Surgical Case Reports, Vol.5, No.1, 110, 2019. (要約) Heterotopic pancreas (HP) is a rare disease commonly found incidentally on imaging studies, at endoscopy or at autopsy and can be associated with abdominal pain, vomiting, heart burn, gastric outlet obstruction, and even dysphagia in very rare cases. Heinrich's classified HP into three groups, types1-3, with Heinrich's type 3 HP the rarest and difficult to diagnose properly because it has only pancreatic ducts but has no islet and acini. The aim of this study is to report a case of gastric outlet obstruction caused by type 3 HP with gastroduodenal invagination with reference to the literature and diagnosed finally by immuno-histochemical analysis. The case presented is a 40-year-old male presenting with vomiting and abdominal pain. Computed tomography (CT) revealed a cystic mass in the upper abdomen and he was referred to the Tokushima University. Gastric fiber showed that the pedunculated mass originated from the stomach. An open distal gastrectomy was performed. Pathologically, there was small glands proliferation in the sub-mucosal (SM) layer which was membrane and cytoplasm (MUC)1 positive and muscle proliferation. This finding revealed the tumor as HP. Postoperative course was uneventful and the patient was discharged 12 days after surgery. The patient has remained well 12 months after surgery. HP should be considered in the differential diagnosis of SM tumors with gastroduodenal invagination even if this is a rare symptom. (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s40792-019-0669-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31292813 ● Search Scopus @ Elsevier (PMID): 31292813 ● Search Scopus @ Elsevier (DOI): 10.1186/s40792-019-0669-7 (DOI: 10.1186/s40792-019-0669-7, PubMed: 31292813)
70.	島田光生, 森根裕二, 池本哲也, 吉川幸造, 髙須千絵 : 免疫チェックポイント時代における漢方とがん免疫, 日本東洋医学雑誌, Vol.70, No.2, 162-166, 2019年. (キーワード) *漢方薬(薬理学,治療的利用) (出版サイトへのリンク) ● Publication site (DOI): 10.3937/kampomed.70.162 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390002184855144320 ● Search Scopus @ Elsevier (DOI): 10.3937/kampomed.70.162 (DOI: 10.3937/kampomed.70.162, CiNii: 1390002184855144320)
71.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Masato Yoshikawa, Hiroki Teraoku and Toshiaki Yoshimoto : A new formula to calculate the resection limit in hepatectomy based on Gd-EOB-DTPA-enhanced magnetic resonance imaging., PLoS ONE, Vol.14, No.1, e0210579, 2019. (要約) Dynamic magnetic resonance imaging with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (EOB-MRI) can be used not only to detect liver tumors but also to estimate liver function. The aim of this study was to establish a new EOB-MRI-based formula to determine the resection limit in patients undergoing hepatectomy. Twenty-eight patients with a normal liver (NL group) and five with an unresectable cirrhotic liver (UL group) who underwent EOB-MRI were included. Standardized liver function (SLF) was calculated based on the signal intensity (SI), the volume of each subsegment (S1-S8), and body surface area. A formula defining the resection limit was devised based on the difference in the SLF values of patients in the NL and UL groups. The formula was validated in 50 patients who underwent EOB-MRI and hepatectomy. The average SLF value in the NL and UL groups was 2038 and 962 FV/m2, respectively. The difference (1076 FV/m2) was consistent with a 70% in resection volume. Thus, the resection limit for hepatectomy was calculated as a proportion of 70%: 70 (SLF-962)/1076 (%). The one patient who underwent hepatectomy over the resection limit died due to liver failure. In other 49 patients, in whom the resection volume was less than the resection limit, procedures were safely performed. Our formula for resection limit based on EOB-MRI can improve the safety of hepatectomy. (徳島大学機関リポジトリ) ● Metadata: 113041 (出版サイトへのリンク) ● Publication site (DOI): 10.1371/journal.pone.0210579 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30682046 ● Search Scopus @ Elsevier (PMID): 30682046 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0210579 (徳島大学機関リポジトリ: 113041, DOI: 10.1371/journal.pone.0210579, PubMed: 30682046)
72.	Jun Higashijima, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara and Chie Takasu : Usefulness of blood flow evaluation by indocyanine green fluorescence system in laparoscopic anterior resection., The Journal of Medical Investigation : JMI, Vol.66, No.1.2, 65-69, 2019. (要約) One of the major cause of anastomotic leakage (AL) in anterior resection of the rectum is insufficient blood flow of the remnant colon. The indocyanine green fluorescence system (ICG-FS) can visualize the blood flow of organs intra-operatively. The aim of this study is to investigate the usefulness of ICG-FS for evaluating the blood flow of the remnant colon in laparoscopic anterior resection. Rectal cancer patients (n=24) who underwent laparoscopic anterior resection were included in this study. After resection of the rectum, 7.5mg of ICG was administered intravenously, and the blood flow of the oral stump was evaluated by the ICG-FS. The relationship between the fluorescence time (FT) of the oral stump and AL was investigated retrospectively. Two of twenty-four patients (8.3%) suffered AL. The FT of these two cases were over 60 seconds. In the case with the FT was over 80 seconds, we performed additional resection of the late fluorescence portion of the remnant colon and could avoid AL. In patients whose FT was under 60 seconds, no patients suffered AL. ICG-FS may be useful for evaluating the blood flow of the remnant colon to avoid AL in laparoscopic anterior resection. J. Med. Invest. 66 : 65-69, February, 2019. (徳島大学機関リポジトリ) ● Metadata: 113323 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.66.65 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064957 ● Search Scopus @ Elsevier (PMID): 31064957 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.65 (徳島大学機関リポジトリ: 113323, DOI: 10.2152/jmi.66.65, PubMed: 31064957)
73.	Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Daichi Ishikawa and Mitsuo Shimada : Utility of virtual three-dimensional image analysis for laparoscopic gastrectomy conducted by trainee surgeons., The Journal of Medical Investigation : JMI, Vol.66, No.3.4, 280-284, 2019. (要約) Purpose The aim of this study was to investigate the utility the three-dimensional (3D) imaging for laparoscopic gastrectomy performed by trainee surgeons. Methods 3D-reconstruction was performed using multi-detector computed tomography (MDCT) and SYNAPSE VINCENT software. Trainee surgeons made 3D-imaging and checked the anatomical structure. Thirty-three patients who underwent laparoscopic gastrectomy (LG) for gastric cancer were examined. Trainees performed 19 LG, while specialists performed 14 LG. The vascular pattern and the surgical outcomes were evaluated. Result 3D imaging depicted the correct positional relationship between the gastric vasculatures and the organs. Regarding vascular pattern detected by 3D imaging, the origins of the infrapyloric artery were the right gastroepiploic artery in 12 cases (36%), the gastroduodenal artery in eight cases (24%), the bifurcation of the right gastroepiploic artery and gastroduodenal artery in seven cases (21%), and not detected in one case (3%). The types of confluence of the infrapyloric vein were the right gastroepiploic vein in 16 cases (48%), the anterior superior pancreatoduodenal vein in 10 cases (30%), and not detected in seven cases (21%). Surgical outcomes were not different between trainee group using intraoperative 3D image with the specialist in instruction group without the intraoperative 3D image. Conclusions Preoperative 3D imaging might contribute to successful and safe LG by trainee surgeons. J. Med. Invest. 66 : 280-284, August, 2019. (徳島大学機関リポジトリ) ● Metadata: 114074 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.66.280 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656289 ● Search Scopus @ Elsevier (PMID): 31656289 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.280 (徳島大学機関リポジトリ: 114074, DOI: 10.2152/jmi.66.280, PubMed: 31656289)
74.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Yasuhiro Hamada : The Effect of Laparoscopic Sleeve Gastrectomy on Obesity and Obesity-related Disease : the Results of 10 Initial Cases., The Journal of Medical Investigation : JMI, Vol.66, No.3.4, 289-292, 2019. (要約) Introduction : The number of patients who undergo laparoscopic sleeve gastrectomy (LSG) has been increasing. Department of Surgery, Tokushima University performed the first LSG in 2013. The aim of this study was to report the results of the initial ten cases who underwent a LSG. Patients and methods : Ten obese patients : five males and five females ; age range from thirty-three years to fifty-six years (mean age 42.2 years) ; mean body mass index (BMI) 50.3 ; five with diabetes ; nine with hypertension (HT) ; four with hyperlipidemia (HL) ; eight with sleep apnea syndrome (SAS) who underwent LSG were enrolled in this study. The data was analyzed retrospectively and included short- and long-term outcomes. Results : There were no post-operative complications in this study. The %EWL at three and six months and one year post-operative were 44.2%, 50.2% and 48.6% respectively. In three months post-operative the non-alcoholic fatty liver (NAFLD) and non-alcoholic steatohepatitis (NASH) had improved transaminase (AST/ALT), liver to spleen ratio in plain CT value. Improvements were also evident in the obesity-related diseases : diabetes 80% (4/5) ; HT 67% (6/9) ; HL 75% (3/4) ; and SAS 88% (7/8). Conclusion : LSG is a promising option for the treatment of morbid obesity and obesity-related diseases. J. Med. Invest. 66 : 289-292, August, 2019. (徳島大学機関リポジトリ) ● Metadata: 114081 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.66.289 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656291 ● Search Scopus @ Elsevier (PMID): 31656291 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.289 (徳島大学機関リポジトリ: 114081, DOI: 10.2152/jmi.66.289, PubMed: 31656291)
75.	Toshiaki Yoshimoto, Yuji Morine, Chie Takasu, Rui Feng, Tetsuya Ikemoto, Kouzou Yoshikawa, Shuichi Iwahashi, Yu Saitou, Hideya Kashihara, Masatake Akutagawa, Takahiro Emoto, Yosuke Kinouchi and Mitsuo Shimada : Blue light-emitting diodes induce autophagy in colon cancer cells by Opsin 3., Annals of Gastroenterological Surgery, Vol.2, No.2, 154-161, 2018. (要約) Light emitting-diodes (LED) have various effects on living organisms and recent studies have shown the efficacy of visible light irradiation from LED for anticancer therapies. However, the mechanism of LED's effects on cancer cells remains unclear. The aim of the present study was to investigate the effects of LED on colon cancer cell lines and the role of photoreceptor Opsin 3 (Opn3) on LED irradiation in vitro. Human colon cancer cells (HT-29 or HCT-116) were seeded onto laboratory dishes and irradiated with 465-nm LED at 30 mW/cm for 30 minutes. Cell Counting Kit-8 was used to measure cell viability, and apoptosis and caspase 3/8 expression were evaluated by AnnexinV/PI and reverse transcription-polymerase chain reaction (RT-PCR), respectively. Autophagy and expression of LC-3 and beclin-1 were also evaluated by autophagy assays, RT-PCR and Western blotting. We further tested Opn3 knockdown by Opn3 siRNA and the G G-protein inhibitor NF023 in these assays. Viability of HT-29 and HCT-116 cells was lower in 465-nm LED-irradiated cultures than in control cultures. LC-3 and beclin-1 expressions were significantly higher in LED-irradiated cultures, and autophagosomes were detected in irradiated cells. The reductive effect of cancer cell viability following blue LED irradiation was reversed by Opn3 knockdown or NF023 treatment. Furthermore, increased LC-3 and beclin-1 expression that resulted from blue LED irradiation was suppressed by Opn3 knockdown or NF023 treatment. Blue LED irradiation suppressed the growth of colon cancer cells and Opn3 may play an important role as a photoreceptor. (徳島大学機関リポジトリ) ● Metadata: 113689 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/ags3.12055 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29863164 ● Search Scopus @ Elsevier (PMID): 29863164 ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12055 (徳島大学機関リポジトリ: 113689, DOI: 10.1002/ags3.12055, PubMed: 29863164)
76.	Masaaki Nishi, Bat-Erdene Batsaikhan, Kozo Yoshikawa, Jun Higashijima, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Daichi Ishikawa and Mitsuo Shimada : High STAT4 Expression Indicates Better Disease-free Survival in Patients with Gastric Cancer., Anticancer Research, Vol.37, No.12, 6723-6729, 2017. (要約) The aim of this study was to investigate the significance of signal transducer and activator of transcription 4 (STAT4) expression and the correlation between STAT4 and interferon gamma (IFN- ) in patients with gastric cancer. Sixty-two patients who underwent gastrectomy for gastric cancer were enrolled in the study. STAT4 and IFNG mRNA expression was evaluated by quantitative real-time polymerase chain reaction (PCR). Immunohistochemistry was performed to examine CD8 T-cells, and STAT4 and IFN- expression. STAT4 mRNA expression was significantly correlated with IFNG mRNA expression (p<0.05). Regarding disease-free survival, there was a significant difference between the groups with high and low STAT4 expression (5-year disease-free survival: 77.8% and 56.4%, p<0.05). Univariate analysis revealed that tumor differentiation and STAT4 expression were significant factors for tumor recurrence. High expression of STAT4 in gastric cancer predicted a better clinical outcome. STAT4 might be a useful biomarker to identify patients at high risk of recurrence after gastrectomy. (キーワード) Aged / Disease-Free Survival / Female / Gastrectomy / Gene Expression Regulation, Neoplastic / Humans / Interferon-gamma / Kaplan-Meier Estimate / Male / Neoplasm Recurrence, Local / Outcome Assessment (Health Care) / Prognosis / STAT4 Transcription Factor / Stomach Neoplasms (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.12131 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29187449 ● Search Scopus @ Elsevier (PMID): 29187449 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.12131 (DOI: 10.21873/anticanres.12131, PubMed: 29187449)
77.	Toshiaki Yoshimoto, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Daichi Ishikawa, Hiroki Teraoku, Masato Yoshikawa, Jun Higashijima, Chie Takasu and Mitsuo Shimada : Maximum Diameter and Number of Tumors as a New Prognostic Indicator of Colorectal Liver Metastases., In Vivo, Vol.31, No.3, 419-423, 2017. (要約) Surgical resection is currently considered the only potentially curative option as a treatment strategy of colorectal liver metastases (CRLM). However, the criteria for selection of resectable CRLM are not clear. The aim of this study was to confirm a new prognostic indicator of CRLM after hepatic resection. One hundred thirty nine patients who underwent initial surgical resection from 1994 to 2015 were investigated retrospectively. Prognostic factors of overall survival including the product of maximum diameter and number of metastases (MDN) were analyzed. Primary tumor differentiation, vessel invasion, lymph node (LN) metastasis, non-optimally resectable metastases, H score, grade of liver metastases, resection with non-curative intent and MDN were found to be prognostic factors of overall survival (OS). In multivariate analyses of clinicopathological features associated with OS, MDN and non-curative intent were independent prognostic factors. Patients with MDN ·30 had shown significantly poorer prognosis than patients with MDN <30 in OS and relapse-free survival (RFS). MDN ·30 is an independent prognostic factor of survival in patients with CRLM and optimal surgical criterion of hepatectomy for CRLM. (キーワード) Adult / Aged / Aged, 80 and over / Cell Differentiation / Colorectal Neoplasms / Female / Follow-Up Studies / Hepatectomy / Humans / Liver Neoplasms / Lymphatic Metastasis / Male / Middle Aged / Multivariate Analysis / Prognosis / Retrospective Studies (出版サイトへのリンク) ● Publication site (DOI): 10.21873/invivo.11076 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28438872 ● Search Scopus @ Elsevier (PMID): 28438872 ● Search Scopus @ Elsevier (DOI): 10.21873/invivo.11076 (DOI: 10.21873/invivo.11076, PubMed: 28438872)
78.	Masato Yoshikawa, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Jun Higashijima, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, Daichi Ishikawa, Hiroki Teraoku, Atsushi Takata, Toshiaki Yoshimoto and Mitsuo Shimada : Elevated Preoperative Serum CEA Level Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma Through the Epithelial-Mesenchymal Transition., Anticancer Research, Vol.37, No.3, 1169-1175, 2017. (要約) Serum carcinoembryonic antigen (CEA) is used as an indicator of tumor progression in a variety of carcinomas. A subset of patients with hepatocellular carcinoma (HCC) exhibit increased serum CEA level, but the significance of this is unclear. In this study, we investigated the prognosis of patients with HCC with increased serum CEA, and explored the correlations with expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and epithelial-mesenchymal transition (EMT) and tumor angiogenesis. One hundred and twenty-three patients with HCC who underwent radical resection were divided into two groups according to a cut-off value of 5.0 ng/ml for serum CEA: high (n=24) and normal (n=99) groups. We compared the clinicopathological factors with serum CEA levels and its correlations with CEACAM1 expression, EMT-related factors and microvessel density (MVD) of tumor tissues by immunohistochemistry. In the high CEA group, the disease-free survival (DFS) rate was significantly worse than in the normal CEA group. Multivariate analysis revealed that a high CEA level was an independent factor predictive of recurrence. Furthermore, increased serum CEA levels were positively correlated with CEACAM1 expression. Moreover, CEACAM1 expression was positively correlated with expression of EMT-related factors and MVD of tumor tissues. Increased serum CEA level reflected CEACAM1 expression and was an independent factor predictive of recurrence in HCC through EMT and tumor angiogenesis. (キーワード) Adult / Aged / Aged, 80 and over / Antigens, CD / Antigens, CD34 / Cadherins / Carcinoembryonic Antigen / Carcinoma, Hepatocellular / Cell Adhesion Molecules / Disease-Free Survival / Epithelial-Mesenchymal Transition / Female / Follow-Up Studies / Humans / Immunohistochemistry / Liver Neoplasms / Male / Microcirculation / Middle Aged / Neovascularization, Pathologic / Predictive Value of Tests / Preoperative Period / Prognosis / Recurrence / Vimentin (徳島大学機関リポジトリ) ● Metadata: 112034 (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.11430 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28314278 ● Search Scopus @ Elsevier (PMID): 28314278 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.11430 (徳島大学機関リポジトリ: 112034, DOI: 10.21873/anticanres.11430, PubMed: 28314278)
79.	M Davaadorj, Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Chie Takasu, Shin-ichiro Yamada, Hiroki Teraoku, Masato Yoshikawa and Mitsuo Shimada : Loss of Secreted Frizzled-Related Protein-1 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma., EJSO - European Journal of Surgical Oncology, Vol.43, No.2, 344-350, 2017. (要約) Secreted Frizzled-Related Protein-1 (SFRP1) is a well-known negative regulator of the wingless type (Wnt)- -catenin pathway and its inactivation plays an important role in the development and progression of many cancers. In this study, we aimed to determine the clinical significance of SFRP1 expression in intrahepatic cholangiocarcinoma (IHCC) and to define the relationship to Wnt- -catenin pathway. Fifty IHCC patients who had liver resection were enrolled in this study. SFRP1 protein expression was examined by immunohistochemistry in tumor tissues. The patients were divided into two groups: SFRP1 positive (n = 30) and negative (n = 20). Clinicopathological characteristics were analyzed. SFRP1 significantly correlated with curability (Cur A, B vs. C, p = 0.029); and recurrent pattern (intrahepatic vs. extrahepatic, p = 0.010). The negative SFRP1 group had significantly poorer prognosis, and 5-year survival rates were 8.1% of the negative SFRP1 group and 44.6% of the positive SFRP1 group, respectively. Moreover, the disease-free survival rate in the negative SFRP1 group was significantly poorer (p < 0.001). Multivariate analysis revealed that loss of SFRP1served as an independent prognostic factor in IHCC for both overall (HR, 2.923; 95% CI, 1.30-6.56; p = 0.009) and disease-free (HR, 2.631; 95% CI, 1.31-5.27; p = 0.006) survival. In addition, SFRP1 expression negatively correlated to -catenin expression (p = 0.005). Those results suggested that the loss of SFRP1 could be a poor prognostic factor for IHCC, through the Wnt- -catenin pathway. (キーワード) Aged / Biomarkers, Tumor / Cholangiocarcinoma / Female / Hepatectomy / Humans / Immunohistochemistry / Japan / Liver Neoplasms / Male / Prognosis / Proteins / Survival Rate (徳島大学機関リポジトリ) ● Metadata: 110034 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ejso.2016.11.017 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28062160 ● Search Scopus @ Elsevier (PMID): 28062160 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejso.2016.11.017 (徳島大学機関リポジトリ: 110034, DOI: 10.1016/j.ejso.2016.11.017, PubMed: 28062160)
80.	髙須千絵, 島田光生 : 【100字de看護・説明を深める!きわめる!消化器外科の病棟で行う治療・処置】, 消化器外科Nursing, Vol.21, No.10, 909-924, 2016年. (キーワード) *尿路カテーテル法(看護) / 和文論文
81.	Shohei Eto, Kouzou Yoshikawa, Masaaki Nishi, Jun Higashijima, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Chie Takasu, Takashi Iwata and Mitsuo Shimada : Programmed cell death protein 1 expression is an independent prognostic factor in gastric cancer after curative resection., Gastric Cancer, Vol.19, No.2, 466-471, 2016. (要約) Programmed cell death protein 1 (PD-1) and its ligand PD-L1 downregulate T cell activation and are related to immune tolerance. The aim of this study was to clarify the significance of PD-1 and PD-L1 expression and to analyze the relationships among PD-1, PD-L1, and Foxp3 expression in gastric cancer. A total of 105 patients who underwent curative gastrectomy for stage II/III gastric cancer were included in this study. PD-1, PD-L1, and Foxp3 expression were examined by immunohistochemistry and related to prognostic factors by univariate and multivariate analyses. PD-1 expression was correlated with both PD-L1 and Foxp3 expression. Disease-free survival (DFS) was significantly poorer in PD-1-positive patients than in PD-1-negative patients (3-year DFS, 36.1 % vs. 64.7 %, respectively; p < 0.05). Overall survival also tended to be poorer in PD-L1-positive patients than in PD-L1-negative patients. Univariate analysis identified sex, T factor, lymphatic invasion, and PD-1 positivity as significant predictors of poor DFS. Multivariate analysis confirmed male sex, lymphatic invasion, and positive PD-1 expression as independent prognostic indicators. PD-1 expression is associated with a poor prognosis and is correlated with PD-L1 and Foxp3 expression in patients with gastric cancer. (キーワード) Adult / Aged / Aged, 80 and over / Antigens, CD274 / Biomarkers, Tumor / Female / Forkhead Transcription Factors / Gastrectomy / Humans / Kaplan-Meier Estimate / Male / Middle Aged / Prognosis / Programmed Cell Death 1 Receptor / Stomach Neoplasms (徳島大学機関リポジトリ) ● Metadata: 109661 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10120-015-0519-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26210691 ● Summary page in Scopus @ Elsevier: 2-s2.0-84937959229 (徳島大学機関リポジトリ: 109661, DOI: 10.1007/s10120-015-0519-7, PubMed: 26210691, Elsevier: Scopus)
82.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara and Chie Takasu : Limited lymph node dissection in elderly patients with gastric cancer., The Journal of Medical Investigation : JMI, Vol.63, No.1-2, 91-95, 2016. (要約) The number of elderly patients with gastric cancer is continuing to increase along with the life expectancy of the general population. The purpose of this study was to investigate both the impact of age on postoperative outcome and the effect of limited lymph node dissection for elderly patients. Patients were classified into the following three groups: Group A, ·80 years old (n=44); Group B, 70-80 years old (n=139); Group C, <70 years old (n=219). Postoperative complication and survival rates were compared between the three groups Results: Limited lymph node dissection was performed significantly more frequently in Group A. In terms of surgery-related complications, no significant difference was seen between groups. In terms of general related complications, the complication rate increased with age, from 4% in Group C to 13% in Group B and 14% in Group A (p<0.05 each). Although limited lymph node dissection was frequently performed in Group A, cancer-specific survival showed no significant difference in R0 patients. Limited lymph node dissection for gastric cancer did not affect the cancer-specific survival in elderly patients. (キーワード) Adult / Age Factors / Aged / Aged, 80 and over / Female / Humans / Japan / Lymph Node Excision / Male / Middle Aged / Postoperative Complications / Stomach Neoplasms / Survival Analysis (徳島大学機関リポジトリ) ● Metadata: 111160 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.63.91 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27040060 ● Search Scopus @ Elsevier (PMID): 27040060 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.63.91 (徳島大学機関リポジトリ: 111160, DOI: 10.2152/jmi.63.91, PubMed: 27040060)
83.	Bat-Erdene Batsaikhan, Kozo Yoshikawa, Nobuhiro Kurita, Takashi Iwata, Chie Takasu, Hideya Kashihara and Mitsuo Shimada : Cyclopamine decreased the expression of Sonic Hedgehog and its downstream genes in colon cancer stem cells., Anticancer Research, Vol.34, No.11, 6339-6344, 2014. (要約) Backround: Most solid cancers including colon cancer are believed to be initiated from and maintained by cancer stem cells (CSCs), that are responsible for treatment resistance, resulting in tumor relapse. The aim of this study was to clarify the possible role of the Sonic Hedgehog (Shh) signaling pathway in the regulation of cancer stem cells. The HCT-116 cell line was cultured with fetal bovine serum in RPMI-1640 medium and its sphere was grown in serum-free non-adherent culture. Gene expressions were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) from cells treated with and without cyclopamine. HCT-116 sphere-derived cells grown in serum-free, non-adherent culture, showed significantly increased expression of stem cell markers, Shh downstream genes and epithelial-mesenchymal transition (EMT) markers compared to parental cells grown in conventional culture. The expression of stemness markers, Shh downstream genes and EMT markers were higher in cancer spheres than the parental cell line and down-regulated by cyclopamine treatment in a dose-dependent manner. Overall, these findings show that cyclopamine treatment could down-regulate the expression of stemness markers, shh downstream genes and EMT markers on HCT-116 spheres. (キーワード) Colonic Neoplasms / Epithelial-Mesenchymal Transition / Hedgehog Proteins / Humans / Neoplastic Stem Cells / RNA, Messenger / Real-Time Polymerase Chain Reaction / Reverse Transcriptase Polymerase Chain Reaction / Tight Junction Proteins / Tight Junctions / Tumor Cells, Cultured / Tumor Markers, Biological / Veratrum Alkaloids (徳島大学機関リポジトリ) ● Metadata: 109370 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25368233 ● Search Scopus @ Elsevier (PMID): 25368233 (徳島大学機関リポジトリ: 109370, PubMed: 25368233)
84.	Noriko Matsumoto, Kouzou Yoshikawa, Mitsuo Shimada, Nobuhiro Kurita, Horohiko Sato, Takashi Iwata, Jun Higashijima, Motoya Chikakiyo, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Shohei Eto, Akira Takahashi, Masatake Akutagawa and Takahiro Emoto : Effect of light irradiation by light emitting diode on colon cancer cells., Anticancer Research, Vol.34, No.9, 4709-4716, 2014. (要約) Recent studies have demonstrated the efficacy of irradiation from light emitting diodes (LED) for wound healing, anti-inflammation and anticancer therapies. However, little is known about the effects of visible light in colon cancer cells. The purpose of this study was to evaluate the biological response (including gene expression changes) of human colon cancer cells to different wavelengths of LED irradiation. Human colon cancer cells (HT29 or HCT116) were seeded onto laboratory dishes that were then put on LED irradiation equipment with a 465 nm-, 525 nm-, or 635 nm-LED. Irradiation at 15 or 30 mW was performed 10 min/day, each day for 5 days. The cell counting kit8 was then used to measure cell viability. Apoptosis and expression of several mRNAs (caspase, MAPK and autophagy pathway) in HT29 cultures irradiated with 465 nm LED were evaluated via AnnexinV/PI and RT-PCR, respectively. Viability of HT29 and HCT116 cells was lower in 465 nm-LED irradiated cultures than in control cultures, but viability of HT29 cells did not differ between control cultures and 525 nm-LED or 635 nm-LED irradiated cultures. Moreover, the expression of FAS, caspase-3, capase-8, and JUK were significantly higher in 465 nm-LED irradiated cultures than in control cultures, and expression of ERK1/2 and LC3 was lower in blue-irradiated cells. LED irradiation at 465 nm inhibited the proliferation of HT29 cells and of HCT116 cells. Notably, LED irradiation at 465 nm promoted apoptosis inHT29 cultures via the extrinsic apoptosis pathway and the MAPK pathway. (キーワード) アポトーシス (apoptosis) / Cell Cycle Checkpoints / Cell Line, Tumor / Cell Proliferation / Cell Survival / Colonic Neoplasms / Dose-Response Relationship, Radiation / Gene Expression Regulation, Neoplastic / HCT116 Cells / HT29 Cells / Humans / Lasers, Semiconductor / Light / Mitogen-Activated Protein Kinases / シグナル伝達 (signal transduction) (徳島大学機関リポジトリ) ● Metadata: 109346 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25202048 ● Summary page in Scopus @ Elsevier: 2-s2.0-84908691381 (徳島大学機関リポジトリ: 109346, PubMed: 25202048, Elsevier: Scopus)
85.	Hideya Kashihara, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Hirohiko Sato, Kozo Yoshikawa, Tomohiko Miyatani, Chie Takasu and Noriko Matsumoto : Protein kinase Cι is a new prognostic factor in gastric cancer., Surgery Today, Vol.45, No.6, 759-764, 2014. (要約) Protein kinase Cι (PKCι) is an important oncogenic K-ras effector, and its expression is correlated with tumor angiogenesis. The role of PKCι in gastric cancer remains unclear. The aim of this study was to clarify the role of PKCι in gastric cancer. Twenty-eight patients with gastric cancer who underwent gastrectomy were enrolled in this study. The expression of PKCι mRNA was determined, as were the clinicopathological factors. The patients were divided into PKCι high and low expression groups. The 5-year survival rate, ERK mRNA level and VEGF mRNA level were compared between the two groups. The prognostic factors were investigated by a multivariate analysis. High expression of PKCι was observed to be associated with a lack of differentiation, tumor invasion ≥muscularis propria≤, stage III and IV disease and peritoneal dissemination. The 5-year survival rate in the PKCι high group was lower than that in the PKCι low group. The multivariate analysis revealed that a high expression level of PKCι was an independent prognostic factor. The expression levels of ERK and VEGF in the PKCι high group were higher than those in the PKCι low group. Our results indicate that PKCι is correlated with tumor progression and angiogenesis. PKCι may be a new prognostic factor for gastric cancer. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00595-014-1010-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25108825 ● Search Scopus @ Elsevier (PMID): 25108825 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-014-1010-5 (DOI: 10.1007/s00595-014-1010-5, PubMed: 25108825)
86.	Bat-Erdene Batsaikhan, Kozo Yoshikawa, Nobuhiro Kurita, Takashi Iwata, Chie Takasu, Hideya Kashihara and Mitsuo Shimada : Expression of Stathmin1 in gastric adenocarcinoma., Anticancer Research, Vol.34, No.8, 4217-4221, 2014. (要約) Over expression of Stathmin1 (STMN1), activation-induced cytidine deaminase (AID) and protein kinase C iota (PKCi) proteins participate in the regulation of carcinogenesis. In the present study, we investigated the expression of STMN1 in patients with gastric adenocarcinoma and also determined the correlation of STMN1 with AID and PKCi proteins. This study was conducted in the Tokushima University Hospital between September 2009 and September 2010 on a total of 59 patients with gastric adenocarcinoma. Stathmin1, AID and PKCi protein expressions were evaluated by immuno-histochemistry in gastric adenocarcinoma. A strong expression of STMN1 was significantly associated with gender- and poorly differentiated gastric adenocarcinoma (p<0.05). A high mRNA level of STMN1 was found in the tumor tissue of gastric adenocarcinoma compared to non-tumor tissue (p<0.05). In addition, STMN1 expression was significantly correlated with AID and PKCi protein expressions in gastric adenocarcinoma (p<0.05). High mRNA level of the Stathmin1 gene was significantly expressed in gastric tumor tissue than non-tumor and strong expression of STMN1 protein is correlated with poorly-differentiated gastric adenocarcinoma. (キーワード) Adenocarcinoma / Adult / Aged / Aged, 80 and over / Cytidine Deaminase / Female / Humans / Isoenzymes / Male / Middle Aged / Protein Kinase C / RNA, Messenger / Stathmin / Stomach Neoplasms (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25075050 ● Search Scopus @ Elsevier (PMID): 25075050 (PubMed: 25075050)
87.	Kozo Yoshikawa, Mitsuo Shimada, Nobuhiro Kurita, Hirohiko Sato, Takashi Iwata, Jun Higashijima, Motoya Chikakiyo, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Noriko Matsumoto and Syohei Eto : Hybrid technique for laparoscopic incisional ventral hernia repair combining laparoscopic primary closure and mesh repair., Asian Journal of Endoscopic Surgery, Vol.7, No.3, 282-285, 2014. (要約) Incisional ventral hernia is one of the most common surgical complications after laparotomy. Laparoscopic repair of incisional ventral hernia has been conducted recently, and the advantages of this procedure have been reported. However, in large orifice cases, the recurrence rate is increased. To improve recurrence rates in large cases, a hybrid method combining laparoscopic primary closure and mesh repair can be applied. Monofilament thread was inserted into the abdominal cavity for hernia closure and pulled from the other side of the orifice. The same procedure was performed from the upper side to the lower side without closure, and all thread was placed in line. Both sides of the thread were then introduced to the midline of the incision through a subcutaneous route. This procedure was conducted with an introducer. All threads were tied, and then a mesh was placed. Hybrid techniques already combine mini-laparotomy for hernia closure and subsequent laparoscopic intraoperative onlay mesh for reinforcement, but such techniques require laparotomy. In our technique, closure of the linea alba does not require laparotomy. All procedures were performed laparoscopically. This procedure is very easy and safe, and does not require the abdominal cavity to be opened. Thus, hybrid methods are effective for treating cases of incisional hernia involving a large orifice. (キーワード) Hernia, Ventral / Herniorrhaphy / Humans / Laparoscopy / Surgical Mesh / Suture Techniques (出版サイトへのリンク) ● Publication site (DOI): 10.1111/ases.12113 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25131330 ● Summary page in Scopus @ Elsevier: 2-s2.0-84929284022 (DOI: 10.1111/ases.12113, PubMed: 25131330, Elsevier: Scopus)
88.	Noriko Matsumoto, Yuji Morine, Tohru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shiniciro Yamada, Daichi Ishikawa, Chie Takasu, Hidenori Miyake and Mitsuo Shimada : Role of CD151 expression in gallbladder carcinoma., Surgery, Vol.156, No.5, 1212-1217, 2014. (要約) CD151 is a member of the tetraspanin family, which interacts with laminin-binding integrins and other tetraspanins. CD151 is involved in several pathologic activities associated with tumor progression, including metastasis and angiogenesis. The aim of this study was to clarify the clinical use of CD151 expression in gallbladder cancer (GBC). Forty-five patients with GBC who had undergone operative treatment were enrolled in this study. Expressions of CD151 in the resected GBC specimens were evaluated with anti-CD151 antibody. The patients were divided into positive and negative groups according to CD151 expression: CD151-positive group (n = 26) and CD151-negative group (n = 19). Clinicopathologic factors, including Ki-67 and matrix metallopeptidase 9, also were compared between the two groups. CD151-positive expression was 58% and correlated with poorer prognosis; 5-year survival of CD151-positive and CD151-negative groups was 29% and 78%, respectively (P = .006). CD151 expression also correlated with lymphatic invasion and curability. Multivariate analysis revealed that CD151-positive expression was an independent prognostic factor (hazard ratio 2.97, P = .02). In addition, CD151 expression correlated with matrix metallopeptidase 9 expression (P < .05) but not with Ki67 expression. Those findings suggested that CD151-positive expression might be a potential prognostic indicator and one of the target molecules for the regulation of tumor metastasis for patients with GBC. (キーワード) Adult / Aged / Aged, 80 and over / Antigens, CD151 / Carcinoma / Female / Gallbladder / Gallbladder Neoplasms / Humans / Immunohistochemistry / Ki-67 Antigen / Male / Matrix Metalloproteinase 9 / Middle Aged / Multivariate Analysis / Prognosis / Tumor Markers, Biological (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.surg.2014.04.053 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24890568 ● Search Scopus @ Elsevier (PMID): 24890568 ● Search Scopus @ Elsevier (DOI): 10.1016/j.surg.2014.04.053 (DOI: 10.1016/j.surg.2014.04.053, PubMed: 24890568)
89.	Hideya Kashihara, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Hirohiko Sato, Kozo Yoshikawa, Tomohiko Miyatani, Chie Takasu, Noriko Matsumoto and Hiroki Ishibashi : Duodenal-Jejunal Bypass Improves Insulin Resistance by Enhanced Glucagon-Like Peptide-1 Secretion Through Increase of Bile Acids., Hepato-Gastroenterology, Vol.61, No.132, 1049-1054, 2014. (要約) The aim of this study is to investigate the mechanisms of improvement in insulin resistance after duodenal-jejunal bypass (DIB), especially regarding the correlation between bile acids and glucagon-like peptide-1 (GLP-1). SD rats were divided into two groups: DIB or Sham group. Blood glucose, insulin, GLP-1, bile acids, and the number of L cells in the small intestine were investigated three weeks after the operations. Next, to assess the effect of the bile acids on GLP-1 secretion in ileum, bile diversion model (=inhibition of rapid bile exposure to the ileum; BD group) were performed and postoperative glycemic parameters were measured. DJB improved insulin resistance and increased GLP-1 compared with sham. Higher bile acids in DJB were found than that in sham. The number of L cells in the common limb of DJB was increased compared with that in the distal segment of sham. In BD group, insulin resistance had not improved. GLP-1, bile acids, and the number of L cells revealed no significant changes compared with sham. DJB has a potential to improve insulin resistance, which may be related to enhanced GLP-1 secretion through the increase of bile acids in the common limb of the small intestine. (出版サイトへのリンク) ● Publication site (DOI): 10.5754/hge13029 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26158164 ● Search Scopus @ Elsevier (PMID): 26158164 ● Search Scopus @ Elsevier (DOI): 10.5754/hge13029 (DOI: 10.5754/hge13029, PubMed: 26158164)
90.	Shinichiro Yamada, Tohru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusue Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Daichi Ishikawa and Mitsuo Shimada : Expressions of hypoxia-inducible factor-1 and epithelial cell adhesion molecule are linked with aggressive local recurrence of hepatocellular carcinoma after radiofrequency ablation therapy., Annals of Surgical Oncology, Vol.21 Suppl 3, S436-42, 2014. (要約) Radiofrequency ablation (RFA) is a widely used therapy for hepatocellular carcinoma (HCC). Several reports have demonstrated the aggressive local recurrence of HCC after RFA, suggesting that induction of further malignant transformation of HCC has occurred. Eighty-eight (88) patients with HCC who underwent hepatic resection were included in this study. Hepatectomy was indicated for local recurrence of HCC after RFA (n = 10, RFA group) and for HCC without prior RFA (n = 78, non-RFA group). Clinicopathological data and the patient's prognosis after hepatectomy were compared between the two groups. Expression levels of hypoxia-inducible factor-1 (HIF-1), epithelial cell adhesion molecule (EpCAM), CD44, and vascular endothelial growth factor messenger RNA (mRNA) in the tumor tissues were also examined. The RFA group showed higher frequency of portal vein invasion and less tumor differentiation compared with the non-RFA group (p < 0.05). Overall and disease-free survival rates in the RFA group were significantly worse than those in the non-RFA group (p < 0.05). HIF-1 and EpCAM mRNA expression levels in the RFA group were significantly higher than those in the non-RFA group (p < 0.05). These results suggest that local HCC recurrence after RFA shows an aggressive tumor phenotype and poor prognosis through the enhanced expressions of HIF-1 and EpCAM in the residual HCC tumors after insufficient or sub-lethal treatment by RFA. (キーワード) Aged / Antigens, CD44 / Antigens, Neoplasm / Carcinoma, Hepatocellular / Case-Control Studies / Catheter Ablation / Cell Adhesion Molecules / Combined Modality Therapy / Female / Follow-Up Studies / Hepatectomy / Humans / Hypoxia-Inducible Factor 1, alpha Subunit / Liver Neoplasms / Male / Neoplasm Recurrence, Local / Neoplasm Staging / Neoplasm, Residual / Prognosis / RNA, Messenger / Real-Time Polymerase Chain Reaction / Reverse Transcriptase Polymerase Chain Reaction / Survival Rate / Tumor Markers, Biological (出版サイトへのリンク) ● Publication site (DOI): 10.1245/s10434-014-3575-z (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24566861 ● Search Scopus @ Elsevier (PMID): 24566861 ● Search Scopus @ Elsevier (DOI): 10.1245/s10434-014-3575-z (DOI: 10.1245/s10434-014-3575-z, PubMed: 24566861)
91.	Bat-Erdene Batsaikhan, Nobuhiro Kurita, Takashi Iwata, Hirohiko Sato, Kozo Yoshikawa, Chie Takasu, Hideya Kashihara, Noriko Matsumoto, Hiroki Ishibashi and Mitsuo Shimada : The role of activation-induced cytidine deaminase expression in gastric adenocarcinoma., Anticancer Research, Vol.34, No.2, 995-1000, 2014. (要約) Gastric adenocarcinoma is one of the most common malignant tumors and the leading cause of malignancy-related death worldwide. Studies have reported overexpression of activation-induced cytidine deaminase (AID) and protein kinase c iota (PKCi) proteins showing involvement in the regulation of carcinogenesis. In the present study, we investigated the expression of AID and PKCi in patients with gastric adenocarcinoma and determined the correlation between these proteins. This study was conducted between September 2009 and September 2010 on a total of 59 patients with gastric adenocarcinoma at the Tokushima University Hospital. AID, PKCi and mutated p53 protein expressions were evaluated by immunohistochemistry in gastric adenocarcinoma. High AID and PKCi expression was significantly (p<0.05) associated with poorly-differentiated gastric adenocarcinoma. In addition, PKCi expression was significantly correlated with clinicopathological findings such as a lymph node metastasis, and venous and lymphatic invasion (p<0.05). Furthermore, AID expression was significantly correlated with PKCi and mutated p53 protein expression in gastric adenocarcinoma (p<0.05). High AID and PKCi expressions were significantly correlated with poorly-differentiated gastric adenocarcinoma. (キーワード) Adenocarcinoma / 成人教育経営 (adult education administration) / Aged / Aged, 80 and over / Cytidine Deaminase / Enzyme Activation / Female / Humans / 免疫組織化学 (immunohistochemistry) / Isoenzymes / Male / Middle Aged / Protein Kinase C / Stomach Neoplasms / Survival Rate / Tumor Suppressor Protein p53 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24511045 ● Search Scopus @ Elsevier (PMID): 24511045 (PubMed: 24511045)
92.	Kozo Yoshikawa, Mitsuo Shimada, Nobuhiro Kurita, Hirohiko Sato, Takashi Iwata, Jun Higashijima, Motoya Chikakiyo, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Noriko Matsumoto and Syohei Eto : Characteristics of internal hernia after gastrectomy with Roux-en-Y reconstruction for gastric cancer., Surgical Endoscopy, Vol.28, No.6, 1774-1778, 2014. (要約) Although the internal hernias have been a huge topic in the field of bariatric surgery, there were a few reports in gastric cancer. The purpose of this study was to analyze the incidence, clinical features, and prevention of internal hernia after gastrectomy for gastric cancer. Twelve patients who underwent surgical treatment for internal hernia in our hospital after gastrectomy were analyzed. Features, including incidence, symptoms, and signs, were investigated in detail. The operative procedures for preceding gastrectomies were open distal gastrectomy in three patients, open total gastrectomy in three patients, laparoscopic-assisted distal gastrectomy in two patients, and laparoscopic total gastrectomy in four patients. The most frequent sites of internal hernias were jejunojejunostomy mesenteric defects (five patients) and Petersen's defect (five patients), mesenterium of transverse colon (one patient), and esophagus hiatus (one patient). There was no significant difference between open and laparoscopic preceding gastrectomies. After closure of the mesenteric defect was introduced, no further internal hernias occurred. On CT examination, the whirl sign was present in ten patients on 3D images. The present data suggest the importance of early recognition and treatment of internal hernia, as well as its prevention by closure of mesenteric defects. (キーワード) Adult / Aged / Aged, 80 and over / Anastomosis, Roux-en-Y / Female / Gastrectomy / Gastric Bypass / Hernia / Herniorrhaphy / Humans / Imaging, Three-Dimensional / Intestinal Diseases / Laparoscopy / Male / Mesentery / Middle Aged / Stomach Neoplasms / Tomography, X-Ray Computed (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00464-013-3384-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24399525 ● Search Scopus @ Elsevier (PMID): 24399525 ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-013-3384-7 (DOI: 10.1007/s00464-013-3384-7, PubMed: 24399525)
93.	岩橋衆一, 居村暁, 宇都宮徹, 森根裕二, 池本哲也, 森大樹, 荒川悠佑, 金本真美, 齋藤裕, 髙須千絵, 島田光生 : 肝移植, 日本臨床外科学会誌, Vol.69, No.4, 2014年.
94.	Chie Takasu, Mitsuo Shimada, Hirohiko Sato, Tomohiko Miyatani, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mami Kanamoto, Nobuhiro Kurita, Shohei Eto and Tohru Utsunomiya : Benefits of simultaneous laparoscopic resection of primary colorectal cancer and liver metastases., Asian Journal of Endoscopic Surgery, Vol.7, No.1, 31-37, 2013. (要約) Recently, consensus on the optimal strategy for resectable synchronous colorectal liver metastases (LM) seems to have shifted toward simultaneous resection. However, there are still relatively few reports about simultaneous laparoscopic resection. The aim of this study is to evaluate the outcomes of patients who underwent simultaneous laparoscopic resection. We evaluated 14 patients who underwent simultaneous resection of primary colorectal cancer and LM in our hospital from 2004 to 2012. Patients were selected by matched pair analysis based on the number of LM (≤4) and tumor size (≤5 cm). We divided them into two groups: the simultaneous laparoscopic resection of primary colorectal cancer and LM (Lap-S) group (n = 7) and the simultaneous open resection of primary colorectal cancer and LM (Open-S) group (n = 7). Clinical and oncologic outcomes were compared between the groups. The Lap-S patients were significantly older than the Open-S patients. The mean operative times of Lap-S and Open-S were 472 min and 466 min, respectively. The mean blood loss was significantly smaller in the Lap-S group (153 mL) than in the Open-S group (496 mL). There was no surgical mortality in either group. The incidence of postoperative complications in the Lap-S and Open-S groups was 12.3% and 33.0%, respectively. The mean postoperative hospital stay was significantly shorter in the Lap-S group (16 days) than in the Open-S group (36 days). There was no significant difference in long-term survival between the two groups. Lap-S patients had equivalent long-term outcomes to Open-S patients. Therefore, given its technical feasibility and safety, Lap-S may be one of the most promising options in selected patients. (キーワード) Aged / Aged, 80 and over / Colectomy / Colorectal Neoplasms / Feasibility Studies / Female / Follow-Up Studies / Hepatectomy / Humans / Kaplan-Meier Estimate / Laparoscopy / Length of Stay / Liver Neoplasms / Male / Middle Aged / Operative Time / Postoperative Complications / Retrospective Studies / Survival Rate / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1111/ases.12066 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24127772 ● Search Scopus @ Elsevier (PMID): 24127772 ● Search Scopus @ Elsevier (DOI): 10.1111/ases.12066 (DOI: 10.1111/ases.12066, PubMed: 24127772)

総説・解説:

1.	西正暁, 島田光生, 吉川幸造, 森根裕二, 東島潤, 柏原秀也, 髙須千絵, 石川大地 : 【がん治療医のための漢方ハンドブック】漢方と癌診療, 臨床外科, Vol.72, No.8, 917-921, 2017年8月.
2.	Shin-ichiro Yamada, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Masato Yoshikawa, Hiroki Teraoku, Toshiaki Yoshimoto and Atsushi Takata : Effective stepwise training and procedure standardization for young surgeons to perform laparoscopic left hepatectomy., Surgical Endoscopy, Vol.31, No.6, 2623-2629, Dec. 2016. (要約) Laparoscopic hepatectomy remains one of the most difficult procedures for young surgeons to perform. We recently developed a new training method and standardization procedure for teaching young surgeons to perform laparoscopic left hepatectomy (Lap-LHx). The aim of this study was to assess the effectiveness of our method. In 2004, we standardized a laparoscopic procedure for Lap-LHx, using a laparoscopy-assisted method as a stepping stone. The laparoscopic training method comprised the following three steps: (1) training in fundamental procedures using a dry box and checking by mentors; (2) detailed preoperative simulation using Vincent three-dimensional software for each patient; and (3) self-assessment including understanding of relevant anatomy and completion grade for each procedure using a check sheet and feedback by both mentors and a professor. Twenty-three Lap-LHx procedures performed during the study period were divided into two groups: those performed by young non-board-certified surgeons (n = 9) and those performed by senior board-certified surgeons (n = 14). The blood loss and operative time were similar in the young surgeon (194 g and 336 min, respectively) and senior surgeon groups (208 g and 322 min, respectively). Our standardized Lap-LHx procedure and stepwise training to perform it enable young surgeons to perform Lap-LHx as confidently and safely as more experienced surgeons. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00464-016-5273-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27928671 ● Search Scopus @ Elsevier (PMID): 27928671 ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-016-5273-3 (DOI: 10.1007/s00464-016-5273-3, PubMed: 27928671)
3.	Shuichi Iwahashi, Mitsuo Shimada, Tohru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Chie Takasu, Yu Saitou and Shinichiro Yamada : Epithelial-mesenchymal transition-related genes are linked to aggressive local recurrence of hepatocellular carcinoma after radiofrequency ablation., Cancer Letters, Vol.375, No.1, 47-50, Mar. 2016. (要約) We reported that poor prognoses of hepatocellular carcinoma (HCC) patients after radiofrequency ablation (RFA) are owing to up-regulation of expression of hypoxia-inducible factor-1 and epithelial cell adhesion molecule. We investigated aggressive progression in residual liver tumors (RLTs) after RFA to focus on expression of epithelial-mesenchymal transition (EMT)-related genes and miRNAs. Ten patients with recurrent HCC post-RFA who underwent hepatectomy (RFA group) and 78 patients with HCC without prior RFA (non-RFA group) were enrolled. We examined expression of transforming growth factor (TGF)-β, Twist, vimentin, and Snail-1 mRNAs in tumor tissues, and expression of miR-34a and miR-200c. Expression of TGF-β, Twist and Snail-1 in the RFA group was significantly higher than that in the non-RFA group (P < 0.05); vimentin expression in the RFA group was higher than that in the non-RFA group (P = 0.07). Expression of miR-200c and miR-34a in the RFA group was significantly lower than that in the non-RFA group (miR-200c: P = 0.04; miR-34a: P < 0.01). Increased expression of EMT markers through down-regulation of miRNA expression in RLTs after RFA may be related to poor prognoses of HCC patients with aggressive local recurrence after RFA. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.canlet.2016.02.041 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26940140 ● Search Scopus @ Elsevier (PMID): 26940140 ● Search Scopus @ Elsevier (DOI): 10.1016/j.canlet.2016.02.041 (DOI: 10.1016/j.canlet.2016.02.041, PubMed: 26940140)
4.	Mandakhnaran Davaadorj, Satoru Imura, Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Shinichiro Yamada, Chie Takasu, Teraoku Hiroki, Masato Yoshikawa and Mitsuo Shimada : Loss of SFRP1 Expression Is Associated with Poor Prognosis in Hepatocellular Carcinoma., Anticancer Research, Vol.36, No.2, 659-664, Feb. 2016. (要約) Secreted frizzled-related protein-1 (SFRP1) is a well-known inhibitor of the wingless type (WNT)-β-catenin signaling pathway and its inactivation plays an important role in the development and progression of various types of cancer. However, the clinical significance of SFRP1 expression in patients with hepatocellular carcinoma (HCC) remains unknown. A total of 63 patients with HCC who underwent hepatectomy at our Institution were enrolled in this study. A quantitative real-time polymerase chain reaction (RT-PCR) was performed to determine the SFRP1 mRNA expression level in both the tumorous and non-tumorous tissues of HCC. The patients were divided into low and high gene-expression groups based on the SFRP1 gene expression level in their tumor tissues. We analyzed the differences in clinicopathological characteristics between these two groups of patients. The expression level of SFRP1 was significantly lower in tumor tissue than in non-tumor tissue (p<0.0001). Significant correlations were observed between a high expression of SFRP1 in tumor tissue and older than 65 years (p=0.030), tumor size less than 5 cm (p=0.011); and no vascular invasion (p=0.004). Patients with high SFRP1 expression in tumor tissue had a significantly better overall survival rate (p=0.040). However, the SFRP1 expression level was not defined as an independent risk factor for patient survival based on results of multivariate analysis. SFRP1 may play a role in the development and progression of HCC. Therefore, more studies are required to investigate a potential role of SFRP1 in HCC prognosis. (キーワード) Adult / Aged / Aged, 80 and over / Biomarkers, Tumor / Carcinoma, Hepatocellular / Disease Progression / Disease-Free Survival / Down-Regulation / Female / Gene Expression Regulation, Neoplastic / Hepatectomy / Humans / Intercellular Signaling Peptides and Proteins / Kaplan-Meier Estimate / Liver Neoplasms / Male / Membrane Proteins / Middle Aged / Multivariate Analysis / Neoplasm Recurrence, Local / Proportional Hazards Models / Prospective Studies / RNA, Messenger / Real-Time Polymerase Chain Reaction / Risk Factors / Time Factors / Treatment Outcome / 欧文論文 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26851021 ● Summary page in Scopus @ Elsevier: 2-s2.0-84979837519 (PubMed: 26851021, Elsevier: Scopus)
5.	齋藤裕, 安井苑子, 濵田康弘, 髙須千絵, 池本哲也, 森根裕二, 居村暁, 島田光生 : 肝胆膵手術例の術前栄養管理, 外科, Vol.76, No.11, 1201-1209, 2014年11月.
6.	吉川幸造, 島田光生, 栗田信浩, 岩田貴, 東島潤, 中尾寿宏, 西正暁, 髙須千絵, 江藤祥平, 吉川雅登, 寺奥大貴 : 【食道癌・胃癌におけるロボット支援手術の有用性】地方での胃癌に対するロボット支援手術導入の現状と問題点, 癌の臨床, Vol.60, No.3, 319-323, 2014年7月. (キーワード) 和文論文
7.	齋藤裕, 島田光生, 石橋広樹, 森根裕二, 居村暁, 森大樹, 荒川悠佑, 岩橋衆一, 髙須千絵 : 【肝胆膵・術後病態を學ぶ】膵胆管合流異常・先天性胆道閉鎖症術後膵胆管合流異常術後発癌の特徴, 肝·胆·膵, Vol.69, No.1, 37-49, 2014年7月. (キーワード) 和文論文
8.	吉川幸造, 島田光生, 栗田信浩, 岩田貴, 佐藤宏彦, 東島潤, 近清素也, 西正暁, 髙須千絵, 柏原秀也, 松本規子 : 【漢方を上手に使う―エビデンスに基づいた外科診療】周術期管理・合併症と漢方高アンモニア血症大建中湯効果のメカニズム, 臨床外科, Vol.68, No.12, 1302-1306, 2013年11月.
9.	Hidenori Miyamoto, 浅野間理仁, 宮本英之, Chie Takasu and Mitsuo Shimada : Visualization and hypervascularization of the haemorrhoidal plexus in vivo using power Doppler imaging transanal ultrasonography and three-dimensional power Doppler angiography., Colorectal Disease, Vol.15, No.11, 686-691, Nov. 2013. (要約) The purpose of this study was to demonstrate the distribution of haemorrhoidal arteries and the relationship between vascularity and growth of haemorrhoids. One-hundred and three patients with haemorrhoids were studied. Using power Doppler imaging (PDI) transanal ultrasound and three-dimensional power Doppler angiography (3D-PDA), the course of the arteries supplying the haemorrhoids was identified. Measurement of the PDI area was made using the cursor to outline the power Doppler signal of the haemorrhoid, approximately 1 cm above the dentate line. The haemorrhoidal arteries were seen as branches of the superior rectal artery and were detected in 75.7, 71.8, 68.0 and 62.1% of the 11, 7, 3 and 1 o'clock positions in the lithotomy position. The median number of haemorrhoidal arteries significantly increased from three to six with progression of the Goligher classification from Grade 1 to Grade 4 (P < 0.0001). The PDI areas in Grades 1, 2, 3 and 4 were 0.04 ± 0.03, 0.18 ± 0.07, 0.38 ± 0.18 and 0.96 ± 0.32 cm(2) (P < 0.05). The distribution of haemorrhoidal arteries varies widely in both number and position. Using PDI transanal ultrasonography and 3D-PDA it was possible to visualize the haemorrhoid plexus and the course of the haemorrhoidal artery in vivo. (キーワード) 英文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/codi.12406 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24034699 ● Summary page in Scopus @ Elsevier: 2-s2.0-84887172265 (DOI: 10.1111/codi.12406, PubMed: 24034699, Elsevier: Scopus)
10.	Yusuke Arakawa, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto and Chie Takasu : Effects of splenectomy on hepatic gene expression profiles after massive hepatectomy in rats., Journal of Gastroenterology and Hepatology, Vol.28, No.10, 1669-1677, Oct. 2013. (要約) Possible spleno-hepatic relationships affected by hepatectomy still remained unclear. We have previously reported that splenectomy may ameliorate liver injuries and promote appropriate liver regeneration after massive hepatectomy. Therefore, we investigated the effects of splenectomy on the DNA expression profile in the liver after massive hepatectomy in rats. Rats were divided into the following two groups: 90% hepatectomy (Hx group) and 90% hepatectomy with splenectomy (Hx + Sp group). Rats were sacrificed 3 and 6 h after surgery, and mRNA from liver tissue was isolated and hybridized to Affymetrix GeneChip Rat Genome 230 2.0 Array (Affymetrix, Santa Clara, CA, USA) and a pathway analysis was done with Ingenuity Pathway Analysis (Ingenuity Systems, Mountain View, CA, USA). We determined the Hx + Sp/Hx ratio to assess the influence of splenectomy, and cut-off values were set at more than 2.0-fold or less than 1/2 (0.5)-fold. Immediate early response gene including early growth response-1 and FBJ murine osteosarcoma-related pathways were markedly downregulated by splenectomy. In contrast, heme oxygenase-1 gene-related pathway was upregulated by splenectomy. Splenectomy provided the protective effects for liver failure and promoted liver regeneration, possibly owing to the downregulation of immediate early response genes and upregulation of the heat shock protein, heme oxygenase-1. (キーワード) 英文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/jgh.12316 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23808869 ● Summary page in Scopus @ Elsevier: 2-s2.0-84897611157 (DOI: 10.1111/jgh.12316, PubMed: 23808869, Elsevier: Scopus)
11.	Kouzou Yoshikawa, Mitsuo Shimada, Nobuhiro Kurita, Hirohiko Sato, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Tomohiko Miyatani, Masato Komatsu, Kashihara hideya and Chie Takasu : The effect of polysaccharide k with S-1 based chemotherapy in advanced gastric cancer., Hepato-Gastroenterology, Vol.60, No.126, 1387-1390, Sep. 2013. (要約) Polysaccharide K (PSK) is widely used in Japan as a biological response modifier for cancer patients. We investigated the effects of PSK with S-1 based chemotherapy for advanced gastric cancer patients in immune response. Nine advanced gastric cancer patients who underwent chemotherapy at the University of Tokushima were included in this study. In all patients, 3g PSK was received orally and S-1 based chemotherapy for 2 weeks alternately for 8 weeks. Serial changes in immunological parameters (Foxp3, Natural killer (NK), CD4/CD8) were monitored. The levels of Foxp3 at 8 weeks was significantly decreased compared with 2 weeks (4.26% vs. 3.11%). In NK activity at 8 weeks was significantly increased compared with 2 weeks (27% vs. 47%). These results of this study suggested that chemotherapy with PSK improved the immune response in advanced gastric cancer patients. Especially Foxp3 was concerned in this mechanism. (キーワード) Aged / Antineoplastic Combined Chemotherapy Protocols / Drug Combinations / Female / Forkhead Transcription Factors / Humans / Killer Cells, Natural / Male / Middle Aged / Oxonic Acid / Proteoglycans / Stomach Neoplasms / Tegafur / 英文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.5754/hge11355 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23933930 ● Search Scopus @ Elsevier (PMID): 23933930 ● Search Scopus @ Elsevier (DOI): 10.5754/hge11355 (DOI: 10.5754/hge11355, PubMed: 23933930)
12.	金本真美, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 岩橋衆一, 齋藤裕, 山田眞一郎, 髙須千絵, 三宅秀則 : 【各種デバイスを応用した私の手術―使用法と工夫】各種デバイスを応用した肝・胆手術, 外科, Vol.75, No.9, 954-959, 2013年9月. (キーワード) 和文論文
13.	近清素也, 佐藤宏彦, 栗田信浩, 岩田貴, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 松本規子, 江藤祥平, 島田光生 : 腹腔鏡下直腸切除術におけるICG蛍光法を用いた腸管血流評価, 日本コンピュータ外科学会誌, Vol.15, No.2, 206-207, 2013年8月. (キーワード) 和文論文 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1573105975984398464 (CiNii: 1573105975984398464)
14.	近清素也, 吉川幸造, 島田光生, 栗田信浩, 岩田貴, 佐藤宏彦, 東島潤, 西正暁, 髙須千絵, 柏原秀也, 松本規子 : 症例報告胃癌術後に直腸転移を来した1例, 四国医学雑誌, Vol.69, No.3.4, 175-178, 2013年8月. (要約) We report a case of rectal metastasis from gastric cancer. The patient was a 69-year-old man with diarrhea as his major symptoms, who underwent a distal gastrostomy for gastric cancer 2 years previously. We suspected primary or metastatic rectal cancer from colonoscopic examination and barium enema. A lower anterior resection was performed. Postoperative historical examination identified poorly differentiated adenocarcinoma and signet cell carcinoma identical to the gastric cancer. Finally the lesion was diagnosed as metastatic rectal cancer from gastric cancer that showed same pattern in PAS stain. There were only 40 cases in reports in the literature from 2002 to 2012, to our knowledge. We report a rare case. (キーワード) 和文論文 (徳島大学機関リポジトリ) ● Metadata: 109633 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050564287688048000 (徳島大学機関リポジトリ: 109633, CiNii: 1050564287688048000)
15.	宮谷知彦, 栗田信浩, 小松正人, 佐藤宏彦, 吉川幸造, 東島潤, 髙須千絵, 柏原秀也, 島田光生 : 抗リン脂質抗体症候群の臨床的特徴に関する検討, 日本外科系連合学会誌, Vol.38, No.4, 759-764, 2013年8月. (キーワード) 和文論文
16.	Chie Takasu, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Hideya Kashihara and Toru Utsunomiya : Impact of C-reactive protein on prognosis of patients with colorectal carcinoma., Hepato-Gastroenterology, Vol.60, No.123, 507-511, May 2013. (要約) The aim of this study was to investigate the impact of preoperative serum C-reactive protein (CRP) level as a prognostic indicator in patients with colorectal carcinoma (CRC). We investigated the correlation between preoperative CRP level and clinicopathological factors including prognosis of 167 patients who underwent resection for CRC retrospectively. Clinicopathological variables were compared between patients with serum CRP levels >1mg/dL (29 patients; high-CRP group) and patients with serum CRP levels <1mg/dL (138 patients; low-CRP group). In high-CRP group, 9 patients were stage I+II and 20 patients ware stage III+IV. In low-CRP group, 93 patients were stage I+II and 45 patients were stage III+IV. There were significant differences in the clinical stage, tumor diameter, curativity, final stage between the two groups (p<0.01). The overall survival and recurrence-free survival rates in high-CRP group were lower compared with the rates in low-CRP group (p<0.05 and p=0.14). In addition, the overall survival rate in stage I+II patients with high-CRP was significantly lower than that in patients with low-CRP (p<0.05). Using multivariate analysis, the preoperative elevation of serum CRP level was an independent prognostic factor in patients with CRC (p<0.05). We found that the preoperative elevation of serum CRP to be an independent prognostic indicator of CRC. (キーワード) Adult / Aged / Aged, 80 and over / C-Reactive Protein / Carcinoma / Colectomy / Colorectal Neoplasms / Disease-Free Survival / Female / Humans / Male / Middle Aged / Multivariate Analysis / Neoplasm Recurrence, Local / Neoplasm Staging / Retrospective Studies / Risk Factors / Survival Analysis / Time Factors / Treatment Outcome / Tumor Markers, Biological / Up-Regulation / 英文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.5754/hge11425 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23635436 ● Search Scopus @ Elsevier (PMID): 23635436 ● Search Scopus @ Elsevier (DOI): 10.5754/hge11425 (DOI: 10.5754/hge11425, PubMed: 23635436)
17.	Hidenori Miyamoto, 浅野間理仁, 宮本英之, Chie Takasu and Mitsuo Shimada : Three-dimensional power Doppler transanal ultrasonography, to monitor haemorrhoidal blood flow after Doppler-guided ALTA sclerosing therapy., Colorectal Disease, Vol.15, No.2, 84-88, Feb. 2013. (要約) The study aimed to use power Doppler imaging (PDI) transanal ultrasonography to produce three-dimensional power Doppler angiography images of haemorrhoidal tissue and to monitor the effects of Doppler-guided aluminium potassium sulfate and tannic acid (DGALTA) sclerotherapy. Ninety-six haemorrhoids in 43 patients were examined using PDI transanal ultrasonography, and DGALTA sclerotherapy was performed from April 2011 to April 2012. DGALTA sclerotherapy was conducted using a four-step injection process with pulse wave Doppler ultrasound under perianal local anaesthesia. A three-dimensional power Doppler angiography image of the blood flow in haemorrhoidal tissue was produced using PDI transanal ultrasonography. The cross-sectional area of blood flow in the haemorrhoidal tissue (PDI area) significantly decreased after DGALTA sclerotherapy. The PDI areas in the preoperative state and 1 and 3 months after treatment were 0.35±0.27, 0.03±0.05 and 0.04±0.05 cm(2) (P<0.0001). A three-dimensional power Doppler angiography image of the haemorrhoidal tissue was technically possible and showed blood flow in the haemorrhoidal tissue to be significantly decreased after DGALTA sclerotherapy. (キーワード) 英文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/codi.12024 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22966905 ● Summary page in Scopus @ Elsevier: 2-s2.0-84873045526 (DOI: 10.1111/codi.12024, PubMed: 22966905, Elsevier: Scopus)
18.	Kouzou Yoshikawa, Mitsuo Shimada, Tomomi Kuwahara, Hideki Hirakawa, Nobuhiro Kurita, Horohiko Sato, Toru Utsunomiya, Takashi Iwata, Tomohiko Miyatani, Jun Higashijima, Hideya Kashihara, Chie Takasu, Noriko Matsumoto and Haruyuki Nakayama-Imaohji : Effect of Kampo medicine "Dai-kenchu-to" on microbiome in the intestine of the rats with fast stress., The Journal of Medical Investigation : JMI, Vol.60, No.3-4, 221-227, 2013. (要約) Diversity of gut microbiome has been recently reported to be lost in inflammatory bowel disease. We have previously reported that the Dai-kenchu-to (DKT) prevented the bacterial translocation through suppression of cytokine and apoptosis in rat's fast stress model. The aim of this study was to evaluate the effect of DKT on maintenance of microbial diversity in rat's intestine with inflammation. Wister rats were received the fast stress for 5 days. In DKT group, rats were administered with DKT (300 mg/kg/day) during the fast stress (DKT-group). The gut microbiomes were analyzed at before- and after- fast stress, and the effect of DKT for on microbial diversities of the gut were evaluated by the PCR-clone library method targeting the 16 S ribosomal RNA gene. In Control-group, Erysipelotrichaceae increased to 86% in after fast stress, OTU of before-fast stress was 111 and after fast stress was only 9 (changing rate: 58%). The diversity of microbiome was severely decreased. On the other hand, in DKT-group, diversity of microbiome was kept after fast stress (Lachnospiraceae: Ruminococcaceae: Coriobacteriales 54%, 22%, 5%), Operational taxonomic units of before fast stress was 52 and after fast stress was 55 (changing rate: 6%). Family Lachnospiraceae which includes butyrate-producing Clostridia (Clostridium IV and XIVa). DKT prevented the reduction of diversity of microbiome in rat's fast stress model. Our data suggested the new anti-inflammatory mechanism of DKT through gut microbiome. (キーワード) 英文論文 (徳島大学機関リポジトリ) ● Metadata: 106360 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.60.221 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24190039 ● Summary page in Scopus @ Elsevier: 2-s2.0-84887006293 (徳島大学機関リポジトリ: 106360, DOI: 10.2152/jmi.60.221, PubMed: 24190039, Elsevier: Scopus)
19.	杉本光司, Toru Utsunomiya, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Chie Takasu and Mitsuo Shimada : Hand-assisted laparoscopic splenectomy for a huge splenic vascular lesion with aneurysms in a patient with impending Kasabach-Merritt syndrome-like phenomenon., The Journal of Medical Investigation : JMI, Vol.60, No.3-4, 276-279, 2013. (要約) Splenic vascular lesions are relatively rare and are usually found incidentally. However, the vascular lesions associated with Kasabach-Merritt syndrome, such as hemangioma, can be life-threatening. We herein describe the case of a young adult female patient with a huge splenic vascular lesion, aneurysms of the splenic artery, and increased plasma levels of fibrin/fibrinogen degradation products and D-dimers. Hand-assisted laparoscopic splenectomy was performed, after which the coagulopathy was drastically improved. Minimally invasive surgical intervention such as hand-assisted laparoscopic splenectomy should be considered as the first treatment choice in such a case. (キーワード) 英文論文 (徳島大学機関リポジトリ) ● Metadata: 106369 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.60.276 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24190048 ● Summary page in Scopus @ Elsevier: 2-s2.0-84887005653 (徳島大学機関リポジトリ: 106369, DOI: 10.2152/jmi.60.276, PubMed: 24190048, Elsevier: Scopus)
20.	Kouzou Yoshikawa, Mitsuo Shimada, Nobuhiro Kurita, Horohiko Sato, Takashi Iwata, Shinya Morimoto, Tomohiko Miyatani, Hideya Kashihara, Chie Takasu and Noriko Matsumoto : Efficacy of PET-CT for predicting the malignant potential of gastrointestinal stromal tumors., Surgery Today, Vol.43, No.10, 1162-1167, Nov. 2012. (要約) Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the intestinal tract. The risk category is usually determined by tumor size and mitotic count, but accurate preoperative diagnosis of GIST is very difficult. The purpose of this study is to evaluate the efficacy of positron emission tomography (PET)-CT for predicting the malignant potential of gastrointestinal stromal tumors. Ten patients with GIST who underwent a preoperative PET-CT examination were divided into two groups by risk category, and various factors were compared between the two groups. The relationships between the maximum standardized uptake value (SUVmax) and GIST parameters were examined. Patients were classified into two groups by their risk category: (low/intermediate-risk or high-risk). The SUVmax was significantly higher in the high-risk group (11.0 ± 3.04) than in the low/intermediate-risk group (2.1 ± 1.5). The Ki67 labeling index was also significantly higher in the high-risk group (8.63 ± 6.2) than in the low/intermediate-risk group (1.75 ± 0.52). There was a significant correlation between the Ki67 labeling index and the SUVmax (p = 0.028) and between the mitotic index and the SUVmax (p = 0.029). PET-CT can predict malignant potential. Cases with a SUVmax of over 5 may have malignant potential. (キーワード) Adult / Aged / Female / Fluorine Radioisotopes / Fluorodeoxyglucose F18 / Gastrointestinal Neoplasms / Gastrointestinal Stromal Tumors / Humans / Male / Middle Aged / Neoplasm Staging / Positron-Emission Tomography / Radiopharmaceuticals / Risk / Tomography, X-Ray Computed / 英文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00595-012-0411-6 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23143169 ● Search Scopus @ Elsevier (PMID): 23143169 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-012-0411-6 (DOI: 10.1007/s00595-012-0411-6, PubMed: 23143169)
21.	Masanori Nishioka, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Shinya Morimoto, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Chie Takasu and H Kashihara : Short-term results of laparoscopic surgery after preoperative chemoradiation for clinically staged T3 and T4 rectal cancer., Asian Journal of Endoscopic Surgery, Vol.5, No.4, 157-163, Nov. 2012. (要約) The feasibility of laparoscopic surgery for clinically staged T3 and T4 rectal cancer has not been clearly defined specifically in cases following preoperative chemoradiation therapy (CRT). Our aim was to investigate the feasibility of laparoscopic surgery after preoperative CRT for clinically staged T3 and T4 rectal cancer. Between May 2003 and June 2009, 57 patients (T3: n = 50, T4: n = 7) who underwent preoperative CRT for rectal cancer were identified. Forty-three patients with laparoscopic surgery (Lap group) were compared with 14 patients who underwent open surgery (Open group). Perioperative data including postoperative morbidity were assessed between the two groups. All patients underwent complete laparoscopic operations, and none was converted to laparotomy. Operating time was longer in the Open group (331 vs 375 min, P < 0.01). Blood loss was lower in the Lap group (160 vs 316 mL, P < 0.01). Lymph node harvest and morbidity rate were similar in both groups. The distal tumor margin was negative in all patients. No patients had perioperative mortality associated with surgery after CRT. Laparoscopic surgery after preoperative CRT is a feasible and a safe option for T3 and T4 rectal cancer compared to conventional open surgery. (キーワード) 欧文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1758-5910.2012.00148.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22883429 ● Summary page in Scopus @ Elsevier: 2-s2.0-84876741246 (DOI: 10.1111/j.1758-5910.2012.00148.x, PubMed: 22883429, Elsevier: Scopus)
22.	Chie Takasu, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, H Kashihara, Toru Utsunomiya and H Uehara : Survivin expression can predict the effect of chemoradiotherapy for advanced lower rectal cancer., International Journal of Clinical Oncology, Vol.18, No.5, 869-876, Aug. 2012. (要約) BACKGROUND: Chemoradiotherapy (CRT) has been used to improve local control and survival in patients with advanced rectal carcinoma. However, a significant proportion of patients show poor response to adjuvant CRT. We thus investigated the usefulness of survivin expression as a predictive marker of the CRT response and its characteristics. METHODS: Forty-three patients with lower rectal cancer who underwent CRT were investigated. All patients received preoperative CRT consisting of TS-1 concurrent with 40 Gy of pelvic irradiation followed by curative resection. The relationship between clinical response, or pathological response, and the expression of survivin of pre-CRT biopsy specimens was evaluated by immunohistochemistry and compared with post-CRT expression. RESULTS: Positive expression of survivin was observed in 26 of 43 patients (60 %) in pre-CRT specimens. Survivin was positively expressed in 77 % of stable disease cases, and 43 % of partial response (p < 0.05). Regarding the correlation between pathological response and survivin expression, positive expression of survivin was recognized in 75 % (18 of 24) of Grade 0 + 1 cases, 50 % (7 of 14) of Grade 2 cases, and 20 % (1 of 5) of Grade 3 cases. A reverse correlation was recognized between pathological responses and survivin expression (p < 0.05). There were differences in the tumor differentiation between the survivin-positive group and the negative group (p < 0.05). The expression concordance rate was 66 % between pre- and post-CRT tissues. In post-CRT tissues, nuclear survivin expression disappeared completely and cytoplasmic expression increased, especially in responder cases. CONCLUSION: Survivin expression in biopsy could be an important predictive factor of preoperative CRT response. (キーワード) 欧文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10147-012-0470-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22936565 ● Search Scopus @ Elsevier (PMID): 22936565 ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-012-0470-0 (DOI: 10.1007/s10147-012-0470-0, PubMed: 22936565)
23.	Horohiko Sato, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Masakazu Goto, H Kashihara and Chie Takasu : Comparison of long-term prognosis of laparoscopy-assisted gastrectomy and conventional open gastrectomy with special reference to D2 lymph node dissection., Surgical Endoscopy, Vol.26, No.8, 2240-2246, Aug. 2012. (要約) Laparoscopy-assisted gastrectomy (LAG) is becoming widely used for early gastric cancer. However, how the curability and long-term prognosis of LAG and open gastrectomy (OG) for early and advanced gastric cancer compare remains unclear. This study assessed short- and long-term outcomes after LAG with lymph node dissection in early and advanced gastric cancer. A total of 332 patients who underwent LAG or OG for early and advanced gastric cancer from January 2001 through December 2010 were reviewed retrospectively. The mean operating time, estimated mean blood loss, number of dissected lymph nodes, and survival rates were compared between LAG and OG for early and advanced gastric cancer. Overall, 47.6% (158/332) of patients underwent LAG; D1, D1+ lymph node dissection was carried out in 77.2%, with D2 dissection in 22.8%. Only one patient required conversion to OG. Comparing LAG and OG with D1, D1+ lymph node dissection for early gastric cancer (EGC), mean operating time was significantly longer, estimated mean blood loss was significantly smaller, and the average number of retrieved lymph nodes was significantly greater with LAG. The rate of specific postoperative morbidity was 17.2% for LAG patients and 25.0% for OG patients, with no postoperative mortality. Survival and recurrence rates were not significantly different. Comparing LAG and OG with D2 lymph node dissection for advanced gastric cancer (AGC), mean operating time was significantly longer and estimated mean blood loss was significantly smaller with LAG, while the average number of retrieved lymph nodes, specific postoperative morbidity and mortality, and survival and recurrence rates were not significantly different. LAG with D1, D1+ lymph node dissection for EGC is safe and equivalent to open gastrectomy in curability. Moreover, LAG with D2 lymph node dissection for AGC is comparable to OG with D2 lymph node dissection with regard to short- and long-term results. (キーワード) 欧文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00464-012-2167-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22311300 ● Search Scopus @ Elsevier (PMID): 22311300 ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-012-2167-x (DOI: 10.1007/s00464-012-2167-x, PubMed: 22311300)
24.	Kouzou Yoshikawa, Mitsuo Shimada, Masanori Nishioka, Nobuhiro Kurita, Takashi Iwata, Shinya Morimoto, Tomohiko Miyatani, Masato Komatsu, H Kashihara and Chie Takasu : The effects of the Kampo medicine (Japanese herbal medicine) ``Daikenchuto'' on the surgical inflammatory response following laparoscopic colorectal resection., Surgery Today, Vol.42, No.7, 646-651, Jul. 2012. (要約) The inflammatory response after surgery is associated with various postoperative complications. The aim of the present prospective study was to evaluate the effects of Daikenchuto (DKT) (a Japanese herbal medicine) on the inflammatory response in patients following laparoscopic colorectal resection. Thirty patients who underwent laparoscopic colectomy for colorectal carcinoma were divided into two groups: a DKT intake group (D group, n = 15) and a control group (C group, n = 15). The D group took 7.5 g/day of DKT from the day after surgery until the 7th postoperative day. The body temperature, heart rate, WBC count, lymphocyte count, C-reactive protein (CRP) level, β-D: -glucan level and Candida index were compared between the two groups. The patients' mean age in the D group was significantly younger than that in the C group. D3 lymph node dissection was performed more often in the D group. The time until first flatus was significantly shorter in the D group (1.8 ± 0.5 days) than in the C group (2.7 ± 0.5 days). The CRP level was significantly lower in the D group (4.6 ± 0.6 mg/dl) than in the C group (8.3 ± 1.1 mg/dl) on the 3rd postoperative day. Postoperative DKT administration significantly suppressed the CRP level and shortened the time until first flatus. DKT administration also significantly suppressed postoperative inflammation following surgery for colorectal cancer. (キーワード) 欧文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00595-011-0094-4 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22202972 ● Summary page in Scopus @ Elsevier: 2-s2.0-84863987987 (DOI: 10.1007/s00595-011-0094-4, PubMed: 22202972, Elsevier: Scopus)
25.	Shinya Morimoto, Mitsuo Shimada, Nobuhiro Kurita, Horohiko Sato, Takashi Iwata, Masanori Nishioka, Kouzou Yoshikawa, Tomohiko Miyatani, H Kashihara, Chie Takasu and Hitoshi Ikushima : Preoperative radiotherapy combined with S-1 for advanced lower rectal cancer: phase I trial., Hepato-Gastroenterology, Vol.59, No.117, 1428-1432, Jul. 2012. (要約) S-1 based chemoradiation is the recommended treatment for rectal cancer; however, the optimal scheduling and dosing are not yet established. A Phase I study was conducted to determine the maximum tolerated dose (MTD) of S-1 with radiotherapy (RT). Endpoints were the toxicity profile of this regimen and to determine the recommended dose (RD). Conformal RT was given using 4 fields at daily fractions of 2Gy on 5 days per week to a total dose of 40Gy. Concurrently S-1 was given twice daily throughout RT. Eligible patients had a newly diagnosed clinical stage T3-4 N0-2 M0 rectal adenocarcinoma located within 12cm of the anal verge suitable for curative resection. Surgery was performed 6 weeks from completion of preoperative chemoradiotherapy. The dose escalating from S-1 80mg/m2/day (Level 1) to 100mg/m2/day (Level 2). Nine patients were valid for safety. In all patients, S-1 was administered. There was no dose-limiting toxicity (DLT) in patients treated at dose Level 1. Six patients were enrolled in the dose-escalation phase. At dose Level 2, two patients developed DLT and this was considered the MTD. Objective response according to RECIST were observed in 5 of 9 patients who had measurable disease (56%). The RD of S-1 with concurrent RT was determined to be 80mg/m2/day. Preoperative RT combined with S-1 was feasible and well tolerated. (キーワード) 欧文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.5754/hge11699 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22155856 ● Search Scopus @ Elsevier (PMID): 22155856 ● Search Scopus @ Elsevier (DOI): 10.5754/hge11699 (DOI: 10.5754/hge11699, PubMed: 22155856)
26.	髙須千絵, 佐藤亮, 渡邉俊介, 上原久典, 泉啓介 : Sinonasal-type hemangiopericytomaの1例, 診断病理, Vol.29, No.3, 227-230, 2012年7月. (キーワード) 和文論文
27.	Tomohiko Miyatani, Nobuhiro Kurita, Toru Utsunomiya, Takashi Iwata, Masanori Nishioka, Kouzou Yoshikawa, Jun Higashijima, H Kashihara, Chie Takasu, M Fukushima and Mitsuo Shimada : Platelet-derived endothelial cell growth factor/thymidine phosphorylase inhibitor augments radiotherapeutic efficacy in experimental colorectal cancer., Cancer Letters, Vol.318, No.2, 199-205, May 2012. (要約) A lot of radiosensitizers have been developed. However, there are few to be available in the clinical setting. Thymidine phosphorylase inhibitor (TPI) regulates the phosphorolysis of thymidine to thymine and 2-deoxy-d-ribose-1-phosphate which is essential for tumor angiogenesis. The aim of this study is to evaluate whether TPI augments the radiotherapy for colorectal cancer in vitro and in vivo studies. The cytotoxicity of TPI with irradiation on HT29 and HCT116 cells was examined using MTT- and colony formation assay. At 10days post-inoculation, HT29 bearing orthotopic model mice (n=28) were divided into four groups and orally treated with TPI- (50mg/kg/day for 2weeks), radiation (RT, 2Gy×4: Total 8Gy), their combination or the vehicle. The mechanisms underlying the efficacy were assessed genomically and immunohistochemically. Compared to each single treatment, the combination of TPI and RT synergistically inhibited the cell viability in a time- and dose-dependent manner. In the HT-29 bearing mice, the combination of TPI and RT reduced the tumor growth compared with RT alone. Notably, the mRNA levels of VEGF, TGF-β and, Rad51 and the protein expressions of VEGF and CD34 were significantly lower in the combination than the others. Furthermore, the combination markedly increased the TUNEL-positive cells, suggesting that TPI augments the cancer cell death through inhibition of angiogenesis and DNA repair system in the radiotherapy. Our study first demonstrated that the combination of TPI and irradiation was effective in colon cancer. TPI would provide a promising therapeutic strategy as a radiosensitizer. (キーワード) 欧文論文 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.canlet.2011.12.010 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22178656 ● Search Scopus @ Elsevier (PMID): 22178656 ● Search Scopus @ Elsevier (DOI): 10.1016/j.canlet.2011.12.010 (DOI: 10.1016/j.canlet.2011.12.010, PubMed: 22178656)
28.	Horohiko Sato, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Masakazu Goto, H Kashihara and Chie Takasu : The safety and usefulness of the single incision, transabdominal pre-peritoneal (TAPP) laparoscopic technique for inguinal hernia., The Journal of Medical Investigation : JMI, Vol.59, No.3-4, 235-240, 2012. (要約) The safety and usefulness of the SILS-TAPP (transabdominal pre-peritoneal) procedure remain unclear. The aim of this study was to clarify the safety and usefulness of the SILS-TAPP procedure compared with standard laparoscopic TAPP and TEPP (totally extra-peritoneal pre-peritoneal) procedures. 85 patients underwent laparoscopic inguinal hernia repairs (TEPP, 30 patients; TAPP, 20 patients; SILS-TAPP, 35 patients) from 2007 to 2011. The operative outcomes of the three groups were compared. There was no difference in the patients' characteristics among the three groups. The TEPP Group had a longer operation time. One patient in the SILS-TAPP group had an intraoperative complication. One patient in the TAPP group had a postoperative complication, and one patient had ileus and one had an umbilical hernia in the SILS-TAPP group. The postoperative hospital stay was not significantly different among the three groups. There were no recurrences in the TEPP group, 1 case of recurrence (5.0%) in the TAPP group, and 1 case (2.9%) in the SILS-TAPP group. The present findings show that the SILS-TAPP repair is safe and feasible for the repair of adult inguinal hernia. (キーワード) 欧文論文 (徳島大学機関リポジトリ) ● Metadata: 106026 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.59.235 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23037193 ● Search Scopus @ Elsevier (PMID): 23037193 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.59.235 (徳島大学機関リポジトリ: 106026, DOI: 10.2152/jmi.59.235, PubMed: 23037193)

国際会議:

1.	Yuuma Wada, Masaaki Nishi, Kouzou Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada : Circulating exosomal microRNA signature to predict peritoneal metastasis in patients with advanced gastric cancer., ASCO-GI, San Francisco, Jan. 2024.
2.	Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto : Immunoscore and Frailty in Colorectal Cancer, IASGO-CME Advanced Post-Graduate Course in Kobe 2023, Kobe, Nov. 2023.
3.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Toshiaki Yoshimoto and Yukako Takehara : The impact of preoperative neutrophil-lymphocyte ratio as the predictive marker of postoperative weight loss and improving diabetes in sleeve gastrectomy., SAGES 2020, クリーブランド, Aug. 2020.
4.	Kouzou Yoshikawa, Mitsuo Shimada, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto : The usefuluness of the OrVil method in LATG, SAGES 2020, クリーブランド, Aug. 2020.
5.	Takuya Tokunaga, Kouzou Yoshikawa, Tomohiko Miyatani, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto, Yukako Takehara and Mitsuo Shimada : The Usefulness of Intraoperative X-ray Fluoroscopy for Avoiding Urethral Injury in Transperineal total Mesorectal Excision, IASGO2019, Bangkok, Oct. 2019.
6.	Toshiaki Yoshimoto, Hideya Kashihara, Chie Takasu, Masaaki Nishi, Takuya Tokunaga, Tomohiko Miyatani, Kouzou Yoshikawa, Yuji Morine and Mitsuo Shimada : The tumor suppressive effects of blue LED via Opn3 in colon cancer, 第10回日本・モンゴル国際消化器癌シンポジウム, ウランバートル, Aug. 2019.
7.	Kouzou Yoshikawa, Mitsuo Shimada, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto : The usefulness of the orVil method in LATG, 第10回日本・モンゴル国際消化器癌シンポジウム, ウランバートル, Aug. 2019.
8.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto : The usefulness of our step-wise training system for robotic assisted gastrectomy, SAGES 2019, Baltimore, Apr. 2019.
9.	Takashi Iwata, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Mitsuo Shimada : Examination of the VR+AR training for understanding of regional anatomy in the laparoscopic training of the students., SAGES 2019, Baltimore, Apr. 2019.
10.	Jun Higashijima, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara and Chie Takasu : Preoperative Chemoradiotherapy for Lower-Advanced Rectal Cancer Patients Using SOX+Bev Regimen, SSO's 72nd Annual Cancer Symposium, San Diego, Mar. 2019.
11.	Shin-ichiro Yamada, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Toshiaki Yoshimoto, Masaaki Nishi and Chie Takasu : Prognostic Prediction of Mass-Forming Intrahepatic Cholangiocarcinoma from Diffusion Weighted Image of Magnetic Resonance Image, SSO's 72nd Annual Cancer Symposium, San Diego, Mar. 2019.
12.	Shoko Iwahashi, Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Chie Takasu, Hideya Kashihara and Mitsuo Shimada : The strategy of zero-mortality due to postoperative VTE in patients with colorectal cancer., ASCO-GI, San Francisco, Jan. 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.1200/JCO.2019.37.4_suppl.511 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2019.37.4_suppl.511 (DOI: 10.1200/JCO.2019.37.4_suppl.511)
13.	Masaaki Nishi, Mitsuo Shimada, Hideya Kashihara, Jun Higashijima, Kouzou Yoshikawa, Takuya Tokunaga, Tomohiko Miyatani, Chie Takasu and Shoko Iwahashi : The impact of sidedness of colorectal cancer in tumor immunity., ASCO-GI, San Francisco, Jan. 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.1200/JCO.2019.37.4_suppl.584 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2019.37.4_suppl.584 (DOI: 10.1200/JCO.2019.37.4_suppl.584)
14.	Mitsuo Shimada, Hiroki Teraoku, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu and Shin-ichiro Yamada : Role of central hypovascularity in the hepatic arterial phase of dynamic CT on mass-forming intrahepatic cholangiocarcinoma., ASCO-GI, San Francisco, Jan. 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.1200/JCO.2019.37.4_suppl.205 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2019.37.4_suppl.205 (DOI: 10.1200/JCO.2019.37.4_suppl.205)
15.	Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto and Mitsuo Shimada : Transanal total mesorectal excision for rectal cancer, 第9回日本・モンゴル国際消化器癌シンポジウム, Aug. 2018.
16.	Yu Saitou, Rui Feng, Chie Takasu, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, Yuji Morine, Satoru Imura and Mitsuo Shimada : Establishment of effective differentiation protocols for insulin-producing cells using a new 3D culture system from adipose-tissue derived mesenchymal stem cell, 27th International Congress of The Transplantation Society(TTS), Jun. 2018.
17.	Mitsuo Shimada, Rui Feng, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Chie Takasu : Establishment of insulin producing cells differentiated from human adipose-derived mesenchymal stem cells using a 3D-culture system with xenoantigen free reagents, 27th International Congress of The Transplantation Society(TTS), Jun. 2018.
18.	Jun Higashijima, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Daichi Ishikawa : Usefulness of indocyanine green (ICG) fluorescence system and thermography for evaluating bloodflow of intestine in laparoscopic anterior resection., SAGES, Seattle, Apr. 2018.
19.	Takashi Iwata, Masashi Akaike, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Daichi Ishikawa and Mitsuo Shimada : Usefulness of the rubric evaluation as the qualitative evaluation of the laparoscopic training., SAGES, Seattle, Apr. 2018.
20.	Shogo Oota, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Daichi Ishikawa : Transabdominal preperitoneal (TAPP) inguinal hernia repair with liquid-injection and gauze dissection., SAGES, Apr. 2018.
21.	Takuya Tokunaga, Mitsuo Shimada, Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Chie Takasu, Hideya Kashihara and Daichi Ishikawa : The Impact of Indoleamine Two to Three-Dioxygenase (IDO) Expression in Colorectal Cancer., SSO's 71st Annual Cancer Symposium, Chicago, Mar. 2018.
22.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Daichi Ishikawa : The impact of indoleamine 2,3-dioxygenase(IDO)expression on stage III gastric cancer., ASCO-GI, San Francisco, Jan. 2018.
23.	Hideya Kashihara, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi, Chie Takasu and Mitsuo Shimada : The Effect of Roux-en-Y Reconstruction on DM and Nonalcoholic Fatty Liver Disease(NAFLD)/Nonalcoholic Steatohepatitis, AMERICAN COLLEGE OF SURGEONS 2017(ACS), San Diego, Oct. 2017.
24.	Daichi Ishikawa, Jun Higashijima, Chie Takasu, Hideya Kashihara, Masaaki Nishi, Takuya Tokunaga, Kouzou Yoshikawa and Mitsuo Shimada : Preoperative chemoradiotherapy for advanced lower rectal cancer using SOX+Bev regimen and role of microRNA-223 as a predictive indicator for the responder., 第9回日本・モンゴル国際消化器癌シンポジウム, ウランバートル, Aug. 2017.
25.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Daichi Ishikawa : The usefulness of the OrVil method and liver mobilization for optimal surgical field in LTG., 第9回日本・モンゴル国際消化器癌シンポジウム, ウランバートル, Aug. 2017.
26.	Masaaki Nishi, Mitsuo Shimada, Tetsuya Ikemoto, Jun Higashijima, Kouzou Yoshikawa, Hideya Kashihara, Chie Takasu and Daichi Ishikawa : Prognostic impact of neutrophil-to-lymphocyte ratio in patients with rectal cancer after preoperative chemoradiotherapy, 47th World Congress of Surgery(WCS), バーゼル, Aug. 2017.
27.	Takashi Iwata, Masashi Akaike, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Daichi Ishikawa and Mitsuo Shimada : Development of the simulator for laparoscopic eye hand coordination training for teaching oneself training, American Gastrointestinal Endoscopic Surgeons, Apr. 2017.
28.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Daichi Ishikawa, Toshiaki Yoshimoto and Atsushi Takata : Feasibility of laparoscopic gastrectomy for elderly patients., SAGES, Houston, Mar. 2017.
29.	Takashi Iwata, Masashi Akaike, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Daichi Ishikawa and Mitsuo Shimada : Development of the simulator for laparoscopic eye hand coordination training for teaching oneself training., SAGES, Houston, Mar. 2017.
30.	Yu Saitou, Yuji Morine, Chie Takasu, Shuichi Iwahashi, Jun Higashijima, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : Role of HSF1 expression for tumor microenvironment in intrahepatic cholangiocarcinoma., ASCO-GI, San Francisco, Jan. 2017. (出版サイトへのリンク) ● Publication site (DOI): 10.1200/JCO.2017.35.4_suppl.249 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2017.35.4_suppl.249 (DOI: 10.1200/JCO.2017.35.4_suppl.249)
31.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi and Chie Takasu : Thrombospondin-1 expressions in non-cancer tissue correlated with gastric carcinogenesis., ASCO-GI, San Francisco, Jan. 2017.
32.	Jun Higashijima, Mitsuo Shimada, Kouzou Yoshikawa, Masaaki Nishi, Hideya Kashihara and Chie Takasu : Preoperative chemoradiotherapy for advanced lower rectal cancer using SOX+Bev regimen., ASCO-GI, San Francisco, Jan. 2017.
33.	Daichi Ishikawa, Tetsuya Ikemoto, Toshiaki Yoshimoto, Atsushi Takata, Masato Yoshikawa, Chie Takasu, Yu Saitou, Shuichi Iwahashi, Yuji Morine, Satoru Imura and Mitsuo Shimada : Signigficance of CD4+CD49b+regulatory T cells and Foxp3+regulatory T cells in the peripheral blood of cancer patients, 40th World Congress of the International College of Surgeons (ICS 2016), Kyoto, Oct. 2016.
34.	Toshiaki Yoshimoto, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Atsushi Takata and Mitsuo Shimada : Ki-67 and Survivin Expressions as Predictive Factors in the Rectal Cancer Treated with Preoperative CRT, 40th World Congress of the International College of Surgeons (ICS 2016), Kyoto, Oct. 2016.
35.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Daichi Ishikawa : The usefulness of the OrVil method and liver mobilization for optimal surgical field in laparoscopic total gastrectomy(LTG), 40th World Congress of the International College of Surgeons (ICS 2016), Kyoto, Oct. 2016.
36.	Toshiaki Yoshimoto, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Atsushi Takata and Mitsuo Shimada : The usefulness of Ki-67 and survivin expressions as predictive factors for the rectal cancer with preoperative CRT, 26th World Congress Of the IASGO 2016, Seoul, Sep. 2016.
37.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Daichi Ishikawa : The Usefulness of the OrVil Method and Liver Mobilization for Optimal Surgical Field in LATG, 26th World Congress Of the IASGO 2016, Seoul, Sep. 2016.
38.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi and Chie Takasu : Risk factoes of the resurrence after laparoscopic gastrectomy for gastric cancer., Society American Gastrointestinal Endoscopic Surgeons (SAGES 2016), Boston, Mar. 2016.
39.	Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Hideya Kashihara : Novel prognostic factor in the colorectal cancer patients who underwent laparoscopic surgery., Society American Gastrointestinal Endoscopic Surgeons (SAGES 2016), Boston, Mar. 2016.
40.	Jun Higashijima, Mitsuo Shimada, Takashi Iwata, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara and Chie Takasu : Usefulness of blood flow Evaluation by indocyanine green fluorescent system in laparoscopic colectomy., Society American Gastrointestinal Endoscopic Surgeons (SAGES 2016), Boston, Mar. 2016.
41.	Takashi Iwata, Masashi Akaike, Kouzou Yoshikawa, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi, Chie Takasu and Mitsuo Shimada : Trial of the filipped classroom for open suturing and simulated laparoscopic cholecystectomy for medical., Society American Gastrointestinal Endoscopic Surgeons (SAGES 2016), Boston, Mar. 2016.
42.	Satoru Imura, Takuya Tokunaga, Masayuki Sumitomo, Shin-ichiro Yamada, Chie Takasu, Yu Saitou, Jun Higashijima, Kouzou Yoshikawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Usefulness of telementoring system to develop laparoscopic surgery in rural hospital, Society American Gastrointestinal Endoscopic Surgeons (SAGES 2016), Boston, Mar. 2016.
43.	Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Yamada Shinichiro, Teraoku Hiroki, Yoshikawa Masato and Chie Takasu : Effective stepwise training and procedure-standardization for young surgeons to perform laparoscopic left hepatectomy., Society American Gastrointestinal Endoscopic Surgeons (SAGES 2016), Boston, Mar. 2016.
44.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Toshihiro Nakao, Hideya Kashihara and Chie Takasu : Sarcopenia with modified glasgow prognostic score is a predictor of long term survival in patients with gastric cancer., 2016 Gastrointestinal Cancers Symposium, San Francisco, Jan. 2016.
45.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara and Chie Takasu : Impact of blue 465nm LED on suppression of cancer growth., 2016 Gastrointestinal Cancers Symposium, San Francisco, Jan. 2016.
46.	Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi, Hideya Kashihara and Chie Takasu : Efeect of preoperative chemoradiotherapy on the long-term outcome for lower rectal cancer, Mongolia Japanese joint Symposium UPPER GI CANCER MANAGEMWNT, Mongol, Sep. 2015.
47.	Jun Higashijima, Mitsuo Shimada, Takashi Iwata, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara and Chie Takasu : Significance of blood flow evaluation by indocyanine green fluorescent system in laparoscopic anterior resection, Mongolia Japanese joint Symposium UPPER GI CANCER MANAGEMWNT, Mongol, Sep. 2015.
48.	Takata Atsushi, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara and Chie Takasu : Utility of virtual three-dimensional image analysis for laparoscopic gastrectomy conducted by trainee surgeons., 46th World Congress of Surgery (WCS)2015, Bangkok, Aug. 2015.
49.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara and Chie Takasu : The usefulness of KI-67 index as predictive factor for the rectal cancer with preoperative chemo-radiotherapy., 46th World Congress of Surgery (WCS)2015, Bangkok, Aug. 2015.
50.	Teraoku Hiroki, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Higashijima, Yu Saitou and Chie Takasu : The expression of KI-67 is a useful prognostic factor in patients with colorectal liver metastasis., 46th World Congress of Surgery (WCS)2015, Aug. 2015.
51.	Mitsuo Shimada, Yuji Morine, Satoru Imura, Yu Saitou, Shin-ichiro Yamada, Jun Higashijima and Chie Takasu : Folfoxiri regimen brings early ``conversion'' and better long-term outcome in patients with initially unresectable colorectal liver metastases, 46th World Congress of Surgery (WCS)2015, Aug. 2015.
52.	Teraoku Hiroki, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, Daichi Ishikawa and Yoshikawa Masato : The expression of Ki-67 is a useful prognostic factor in patients with colorectal liver metastasis, IASGO 2015 post graduate course, Tokyo, Jun. 2015.
53.	Jun Higashijima, Mitsuo Shimada, Takashi Iwata, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara, Chie Takasu and 江藤祥平 : Significance of blood flow evaluation by indocyanine green fluorescent system in laparoscopic anterior resection, IASGO 2015 post graduate course, Tokyo, Jun. 2015.
54.	Takashi Iwata, Masashi Akaike, Kouzou Yoshikawa, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, 江藤祥平 and Mitsuo Shimada : Investigation of training for students who is weak in maneuver of laparoscopic surgery Laborer of the off-the-job training, Surgical Education Week, Seattle, Apr. 2015.
55.	Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴, 吉川雅登, Jun Higashijima and Chie Takasu : Impact of FOLFOXIRI regimen on early ``Conversion'' and long-term outcome in patients with initially unresectable colorectal liver metastases, ASCO-GI 2015 Gastrointestinal Cancers Symposium, Jan. 2015.
56.	Eto Shohei, Takashi Iwata, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu and Mitsuo Shimada : Relationship of programmed death 1(PD-1)expression to the recurrence in gastric cancer., ASCO-GI 2015 Gastrointestinal Cancers Symposium, San Francisco, Jan. 2015.
57.	Jun Higashijima, Mitsuo Shimada, Takashi Iwata, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Chie Takasu and Eto Shohei : Significance of platinum concentration in blood and red blood cell in patients with oxaliplatin-based chemotherapy., ASCO-GI 2015 Gastrointestinal Cancers Symposium, San Francisco, Jan. 2015.
58.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Toshihiro Nakao, Chie Takasu, 寺奥大貴 and 江藤祥平 : Effect of light irradiation by light emitting diode on colon cancer cells and cancer stem cells., ASCO-GI 2015 Gastrointestinal Cancers Symposium, 271, San Francisco, Jan. 2015. (キーワード) 国際学会 (出版サイトへのリンク) ● Publication site (DOI): 10.1200/jco.2015.33.3_suppl.271 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1200/jco.2015.33.3_suppl.271 (DOI: 10.1200/jco.2015.33.3_suppl.271)
59.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, D Ishikawa, Chie Mikami, Z Chengzhan, A Tajima and I Imoto : Identification of aberrant DNA methylation profiles in non-tumor liver tissues of patients with non-B, non-C hepatocellular carcinoma., Gastrointestinal Cancers Symposium(ASCO-GI), San Francisco, Jan. 2014. (キーワード) 国際学会
60.	Motoya Chikakiyo, Horohiko Sato, Nobuhiro Kurita, Takashi Iwata, Kouzou Yoshikawa, 柏原秀也, Chie Takasu, 松本規子, 江藤祥平, Mitsuo Shimada, Masanori Hotsuchi, Hiroshi Okitsu, 惣中康秀 and 吉田禎宏 : A multicenter exploratory study of irinotecan-based chemotherapy on UGT1A1 polymorphisms for patients with colorectal cancer., Gastrointestinal Cancers Symposium(ASCO-GI), San Francisco, Jan. 2014.
61.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Chie Takasu, Chengzhan Zhu, Tajima A and Imoto I : Identification of aberrant DNA methylation profiles in non-tumor liver tissues of patients with non-B, non-C hepatocellular carcinoma., Gastrointestinal Cancers Symposium(ASCO-GI), San Francisco, Jan. 2014.
62.	江藤祥平, Takashi Iwata, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu and Mitsuo Shimada : Relationship of programmed death 1(PD-1)expression to the recurrence in gastric cancer., ASCO-GI 2015 Gastrointestinal Cancers Symposium, San Francisco, Jan. 2014. (キーワード) 国際学会
63.	Jun Higashijima, Mitsuo Shimada, Takashi Iwata, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Chie Takasu and 江藤祥平 : Significance of platinum concentration in blood and red blood cell in patients with oxaliplatin-based chemotherapy., ASCO-GI 2015 Gastrointestinal Cancers Symposium, San Francisco, Jan. 2014. (キーワード) 国際学会
64.	Nobuhiro Kurita, Mitsuo Shimada, Takashi Iwata, Horohiko Sato, Kouzou Yoshikawa, Tomohiko Miyatani, 柏原秀也, Chie Takasu and 松本規子 : Anti-Thrombotic Prophylaxis to Prevent Postoperative Venous Thromboembolism for High-Risk Patients after Abdomino-Pelvic Major Surgery., American College of Surgeons 2013(ACS), Washington, D.C., Oct. 2013.
65.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and Chie Takasu : Potential Predictive Factors for Microscopic Portal Invasion in Hepatocellular Carcinoma wwithout Macroscopic Vascular Invasion., American College of Surgeons 2013(ACS), Washington, D.C., Oct. 2013.
66.	Masaaki Nishi, Mitsuo Shimada, Nobuhiro Kurita, Horohiko Sato, Kouzou Yoshikawa, Tomohiko Miyatani, 柏原秀也, Chie Takasu and 松本規子 : Feasibility of Laparoscopic Surgery for Lower Rectal Cancer after CRT., International Association of Surgeons, Gastroenterologists and Oncologists 2013(IASGO), ブカレスト, Sep. 2013.
67.	Kouzou Yoshikawa, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Jun Higashijima, Motoya Chikakiyo, Masaaki Nishi, 柏原秀也, Chie Takasu and 松本規子 : The Utility of PET-CT and MRI in Predicting Malignant Poteential of GIST., International Association of Surgeons, Gastroenterologists and Oncologists 2013(IASGO), ブカレスト, Sep. 2013.
68.	Nobuhiro Kurita, Mitsuo Shimada, Takashi Iwata, Horohiko Sato, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, 柏原秀也, Chie Takasu and 松本規子 : Strategy for Major Complications after LAG for Gastric Cancer., International Association of Surgeons, Gastroenterologists and Oncologists 2013(IASGO), Bucharest, Sep. 2013.
69.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto and Chie Takasu : Significance of Stem Cell Markers Expression in Cholangiolocellular Carcinoma., International Association of Surgeons, Gastroenterologists and Oncologists 2013(IASGO), ルーマニア, Sep. 2013.
70.	Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu and 山田眞一郎 : Recent Advancements in Liver Surgery: Assessment of Funcional Reserve, Simulation and Navigation., International Association of Surgeons, Gastroenterologists and Oncologists 2013(IASGO), ルーマニア, Sep. 2013.
71.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Tetsuya Ikemoto, 山田眞一郎 and Chie Takasu : The homing effect of adipose-derived stem cells to the injured liver: The shift of stromal cellderived factor 1 expressions., The 13th Congress of the Asian Society Of Transplantation 2013(CAST), Kyoto, Sep. 2013.
72.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya, Horohiko Sato and Hidenori Miyake : The gene profile in the spleen under rat small-for-size graft model using cDNA microarray and pathway analaysis., The 13th Congress of the Asian Society Of Transplantation 2013(CAST), Kyoto, Sep. 2013.
73.	柏原秀也, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Kouzou Yoshikawa, Tomohiko Miyatani and Chie Takasu : The usefulness of the volume rendering simulation in laparoscopic colectomy for transverse colon cancer., Society of American Gastrointestinal and Endoscopic Surgeons 2013(SAGES), Baltimore, Apr. 2013.
74.	Nobuhiro Kurita, Mitsuo Shimada, Takashi Iwata, Horohiko Sato, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, 柏原秀也, Chie Takasu and 松本規子 : Profile and measures of postoperative complications after lapararoscopy assisted gastrectomy for gastric cancer., Society of American Gastrointestinal and Endoscopic Surgeons 2013(SAGES), Baltimore, Apr. 2013.
75.	Keisuke Izumi, Chie Takasu, Tetsuyuki Takahashi and Hisanori Uehara : Serum biochemistry and microarray analysis of liver and colonic mucosa in LETO and OLETF rats treated with 20% caloric restriction and high-fat diet, American Association for Cancer Research 104th Annual Meeting, Apr. 2013.
76.	柏原秀也, Mitsuo Shimada, Nobuhiro Kurita, Horohiko Sato, Takashi Iwata, Kouzou Yoshikawa, Tomohiko Miyatani, Chie Takasu and 松本規子 : The effect of duodenal-jejunal bypass on type2 diabetes., 22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2012), Dec. 2012. (キーワード) 国際学会
77.	Chie Takasu, Mitsuo Shimada, Nobuhiro Kurita, Horohiko Sato, Masanori Nishioka, Kouzou Yoshikawa, Tomohiko Miyatani, 柏原秀也, Chie Takasu and 松本規子 : Simultaneous laparoscopic resection of primary colorectal cancer and metastatic liver tumor., 22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2012), Dec. 2012. (キーワード) 国際学会
78.	Tomohiko Miyatani, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Kouzou Yoshikawa, 柏原秀也, Chie Takasu and 松本規子 : Prognosis after CONVERSION in patients with unresectable liver metastases from colorectal cancer., 22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2012), Dec. 2012. (キーワード) 国際学会
79.	Horohiko Sato, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Kouzou Yoshikawa, Tomohiko Miyatani, 柏原秀也, Chie Takasu and 松本規子 : Comparison of long-term prognosis of laparoscopy-assisted gastrectomy and conventional open gstrectomy with special reference to D2 lymph node dissection., 22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2012), Dec. 2012. (キーワード) 国際学会
80.	松本規子, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, 柏原秀也 and Chie Takasu : Laparoscopic surgery for Stage IV colorectal cancer is safe and feasible., The13th KOREA-JAPAN-CHINA COLORECTAL CANCER SYMPOSIUM, Sep. 2012. (キーワード) 国際学会
81.	Tomohiko Miyatani, Toru Utsunomiya, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Jun Higashijima, 柏原秀也, Chie Takasu and Mitsuo Shimada : Randomized clinical trial of preoperative chemoradiotherapy by S- vs UFT to rectal cancer for personalized therapy., The13th KOREA-JAPAN-CHINA COLORECTAL CANCER SYMPOSIUM, Seoul, Sep. 2012. (キーワード) 国際学会
82.	Horohiko Sato, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, 柏原秀也, Chie Takasu and 松本規子 : Laparoscopic Surgery after Preoperative Chemoradiation Therapy is a Safe and Feasible Option for T3 and T4 Rectal Cancer., 4th Japanese-Mongolian International Cancer Joint Symposium, Sep. 2012. (キーワード) 国際学会
83.	Takashi Iwata, Nobuhiro Kurita, Horohiko Sato, Kouzou Yoshikawa, Tomohiko Miyatani, 柏原秀也, Chie Takasu, 松本規子 and Mitsuo Shimada : What is the Best Training for Laparoscopy Assisted Gastrectomy?, 4th Japanese-Mongolian International Cancer Joint Symposium, Sep. 2012. (キーワード) 国際学会
84.	Chie Takasu, Mitsuo Shimada, Kouzou Yoshikawa, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Shinya Morimoto, Tomohiko Miyatani and 柏原秀也 : The effect of Dai-kenchu-to in maintenance of microbiomal diversity on intestinal inflammation., Digestive Disease Week (DDW2012), May 2012. (キーワード) 国際学会
85.	Chie Takasu, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Masakazu Goto, 柏原秀也 and Toru Utsunomiya : Simultaneous laparoscopic resection of primary colorectal cancer and metastatic liver tumor., Society of American Gastrointestinal Endoscopic Surgeons (SAGES2012), San Diego, Mar. 2012.
86.	Shinya Morimoto, Mitsuo Shimada, Nobuhiro Kurita, Horohiko Sato, Takashi Iwata, Masanori Nishioka, Tomohiko Miyatani, Kouzou Yoshikawa, Masakazu Goto, 柏原秀也 and Chie Mikami : Laparoscopic surgery after preoperative chemoradiation for advanced lower rectal cancer., Society of American Gastrointestinal Endoscopic Surgeons (SAGES2012), San Diego, Mar. 2012.
87.	Nobuhiro Kurita, Mitsuo Shimada, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Masakazu Goto, 柏原秀也 and Chie Mikami : The utility of standardization of laparoscopy assisted gastrectomy and introduction of telesurgery mentoring system., Society of American Gastrointestinal Endoscopic Surgeons (SAGES2012), San Diego, Mar. 2012.
88.	柏原秀也, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Chie Takasu and Tomohiko Miyatani : Protein Kinase Ciota is a new prognostic factor in gastric cancer., American Association for Cancer Research (AACR2012), Chicago, Mar. 2012.
89.	柏原秀也, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Kouzou Yoshikawa, Tomohiko Miyatani and Chie Takasu : Feasibility study of irinotecan based on UGT1A1 polynorphisms for metastatic colorectal cancer: Interin report., Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2012), San Francisco, Jan. 2012.
90.	Tomohiko Miyatani, Toru Utsunomiya, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Jun Higashijima, 柏原秀也, Chie Takasu and Mitsuo Shimada : Randomized clinical trial of preoperative chemoradiotherapy by S-1 versus UFT to rectal cancer for personalized therapy., Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2012), San Francisco, Jan. 2012.
91.	Kouzou Yoshikawa, Mitsuo Shimada, Nobuhiro Kurita, Horohiko Sato, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Tomohiko Miyatani, 柏原秀也 and Chie Takasu : The utility of PET-CT in predicting malignant potential of GIST., Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2012), San Francisco, Jan. 2012.
92.	Horohiko Sato, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Masakazu Goto, 柏原秀也 and Chie Takasu : Assessment of gastric cancer malignancy based on CD133 and thrombospondin1(THBS1) expression and the role of histone acetylation., Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2012), San Francisco, Jan. 2012.
93.	Tomohiko Miyatani, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Jun Higashijima, 柏原秀也 and Chie Takasu : Impact of laparoscopic Surgery for lower rectal cancer with preoperative chemoradiation on postopretive anorectal function., 21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologigts(IASGO2011), Tokyo, Nov. 2011.
94.	Masanori Nishioka, Mitsuo Shimada, Toru Utsunomiya, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, 柏原秀也 and Chie Takasu : A phase II trial of preoperative chemoradiotherapy with oral DPD-inhibitory fluoropyrimidines in patients with advanced rectal cancer., 21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologigts(IASGO2011), Tokyo, Nov. 2011.
95.	Horohiko Sato, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Masakazu Goto, 柏原秀也 and Chie Takasu : Role of thrombospondin1(THBS1) expression in peritoneal metastasis of gastric cancer treated with taxanes., 21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologigts(IASGO2011), Tokyo, Nov. 2011.
96.	柏原秀也, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani and Chie Takasu : The mechanism of improvement on glucose tolerance after Duodenal-jejunal bypass., 21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologigts(IASGO2011), Tokyo, Nov. 2011.
97.	Nobuhiro Kurita, Mitsuo Shimada, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Masakazu Goto, 柏原秀也 and Chie Takasu : Long-term results of laparoscopy assisted gastrectomy for gastric cancer according to Japanese classification of gastric carcinoma (JCGC) stage-comparison with the results of open surgery-., 21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologigts(IASGO2011), Tokyo, Nov. 2011.
98.	Masakazu Goto, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Horohiko Sato, Masanori Nishioka, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, 柏原秀也 and Chie Takasu : Taylor-made therapy for rectal cancer Role of microRNA-223 expression-., 8th International Simposium on Minimal Residual Cancer (ISMRC2011), Osaka, Sep. 2011.
99.	Tomohiko Miyatani, Mitsuo Shimada, Nobuhiro Kurita, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, 柏原秀也 and Chie Mikami : Laparoscopic surgery after preoperative chemoradiation therapy for advanced rectal cancer is a safe and feasible option., International Surgical Week ISW 2011, Yokohama, Aug. 2011.
100.	Kouzou Yoshikawa, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Shinya Morimoto, Tomohiko Miyatani, Chie Mikami and Masanori Nishioka : Role of thrombospondin 1 (THBS1) expression in peritoneal metastasis of gastric cancer treated with taxanes., International Surgical Week ISW 2011, Yokohama, Aug. 2011.
101.	Takashi Iwata, Mitsuo Shimada, Nobuhiro Kurita, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Jun Higashijima, Chie Mikami and 柏原秀也 : Investigation of expression of RAD51 in biopsied apecimen as a predictive factor of chemo-radiation therapy for advancer rectal cancer., 102nd American Association for Cancer Research (AACR2011), Orlando, Apr. 2011.
102.	Masanori Arita, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Chie Mikami and Hideya Kashihara : The significance of laparoscopic surgery for stage colorectal cancer, Society of American Gastrointestinal Endoscopic Surgeons (SAGES2011), テキサス, Mar. 2011.
103.	Hideya Kashihara, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Kouzou Yoshikawa, Tomohiko Miyatani, Chie Mikami and Toru Utsunomiya : The safety and usefulness of single incision laparoscopic TAPP, Society of American Gastrointestinal Endoscopic Surgeons (SAGES2011), テキサス, Mar. 2011.
104.	Kouzou Yoshikawa, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Tomohiko Miyatani, Chie Mikami and Hideya Kashihara : Technical feasibility and safety of esophagojejunostomy using overlap technique after laparoscopic, Society of American Gastrointestinal Endoscopic Surgeons (SAGES2011), テキサス, Mar. 2011.
105.	Chie Mikami, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Tomohiko Miyatani and Hideya Kashihara : A randomized phase study of modified OPTIMOX1 or FOLFOX in advanced colorectal cancer, Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2011), San Francisco, Jan. 2011.
106.	Shinya Morimoto, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Kouzou Yoshikawa, Tomohiko Miyatani, Chie Mikami and Hideya Kashihara : The role of UGT1A1 polymorphisms (28 and 26) in Japanese cancerpatients, Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2011), San Francisco, Jan. 2011.
107.	Shinya Morimoto, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Kouzou Yoshikawa, Tomohiko Miyatani, Chie Mikami and Hideya Kashihara : Effect of Kampo medicine Juzen-taiho-to on adverse events induced by cetuximab, Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2011), San Francisco, Jan. 2011.
108.	Masanori Nishioka, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Shinya Morimoto, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Hideya Kashihara and Chie Mikami : A randomized phase trial of chemoradiotherapy with oral fluoropyrimidine inhibitory for dihydropyrimidine dehydrogenase for low rectal cancer: An interim report, Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2011), San Francisco, Jan. 2011.
109.	Nobuhiro Kurita, Mitsuo Shimada, Takashi Iwata, Masanori Nishioka, Yuji Morine, Kouzou Yoshikawa, Tomohiko Miyatani, Chie Mikami and Hideya Kashihara : Role of thrombospondin 1(THBS1) expression in peritoneal metastasis of gastric cancer treated with taxanes, Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2011), San Francisco, Jan. 2011.
110.	Hideya Kashihara, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Chie Mikami and Toru Utsunomiya : The growth inhibitory effect of human adipose tissue derived stem cell on pancreas and colon cancer cells, 20th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO2010), エジプト, Oct. 2010.
111.	Kouzou Yoshikawa, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Shinya Morimoto, Tomohiko Miyatani, Hideya Kashihara and Chie Mikami : Effect of kampo medicine, dai-kenchu-to, on bacterial translocation, 20th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO2010), エジプト, Oct. 2010.
112.	Masanori Nishioka, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Shinya Morimoto, Kouzou Yoshikawa, Jun Higashijima, Hideya Kashihara and Chie Mikami : Promising strategy of lower rectal cancer: Chemo-radiation followed by laparoscopic surgery, 20th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO2010), エジプト, Oct. 2010.

国内講演発表:

1.	和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : 胃癌腹膜播種予測におけるエクソソームmiRNAの有用性, 第96回日本胃癌学会総会, 2024年2月.
2.	髙須千絵, 西正暁, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 : 局所進行胃癌に対するロボット支援手術の工夫と成績, 第96回日本胃癌学会総会, 2024年2月.
3.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 : 食道胃接合部腺癌に対する経裂孔ロボット支援手術, 第96回日本胃癌学会総会, 2024年2月.
4.	Kouzou Yoshikawa, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto : The ingenuity of robotic surgery for advanced gastric cancer, 第96回日本胃癌学会総会, Feb. 2024.
5.	和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : エクソソームmiRNAを用いての胃癌腹膜播種の予測, 第56回制癌剤適応研究会, 2024年2月.
6.	良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 : 下部直腸癌に対するTaTME併用ロボット支援下直腸切除術の有用性, 第120回日本消化器病学会四国支部例会, 2023年12月.
7.	良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 : ロボット支援前立腺全摘後の鼠径ヘルニアに対する腹腔鏡下ヘルニア修復術についての検討, 第36回日本内視鏡外科学会総会, 2023年12月.
8.	和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : 腹腔鏡下胃癌手術におけるトレーニングプログラムの確立, 第36回日本内視鏡外科学会総会, 2023年12月.
9.	徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 直腸癌に対する経肛門的側方リンパ節郭清の手術手技と短期成績の検討, 第36回日本内視鏡外科学会総会, 2023年12月.
10.	髙須千絵, 西正暁, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 : 局所進行胃癌に対するロボット支援手術の工夫と成績, 第36回日本内視鏡外科学会総会, 2023年12月.
11.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 非アルコール性脂肪肝炎に対する減量・代謝改善手術の意義, 第36回日本内視鏡外科学会総会, 2023年12月.
12.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 : 食道胃接合部腺癌に対するロボット手術(経裂孔アプローチ)の有用性, 第36回日本内視鏡外科学会総会, 2023年12月.
13.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 他臓器浸潤を伴う直腸癌に対する経肛門アプローチの有用性, 第36回日本内視鏡外科学会総会, 2023年12月.
14.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 胃全摘OrVil法におけるピットフォールとトラブルシューティング, 第36回日本内視鏡外科学会総会, 2023年12月.
15.	良元俊昭, 徳永卓哉, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 : 再発直腸癌に対する経肛門アプローチにおけるホログラムの有用性, 第32回日本コンピュータ外科学会大会, 2023年12月.
16.	和田佑馬, 髙須千絵, 森根裕二, 池本哲也, 齋藤裕, 山田眞一郎, 脇悠平, 寺奥大貴, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 良元俊昭, 島田光生 : 肝細胞癌におけるエクソソームmiRNAを介したLenvatinib耐性機序の検討, 第34回日本消化器癌発生学会総会, 2023年11月.
17.	徳永卓哉, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 : 青色LEDはmetabolic couplingを抑制することで抗腫瘍効果をもたらす, 第34回日本消化器癌発生学会総会, 2023年11月.
18.	西正暁, 和田佑馬, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 : 胃癌腹膜播種診断マーカーの臨床的有用性, 第34回日本消化器癌発生学会総会, 2023年11月.
19.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 大腸癌におけるImmunoscoreとフレイルの予後に与える影響, 第34回日本消化器癌発生学会総会, 2023年11月.
20.	良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 : 青色LED光による大腸癌の光受容体をターゲットとした治療法の開発, 第85回日本臨床外科学会総会, 2023年11月.
21.	和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : 腹腔鏡下胃癌手術のトレーニングプログラム, 第85回日本臨床外科学会総会, 2023年11月.
22.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 : 食道胃接合部腺癌に対するロボット手術(経裂孔)の有用性, 第85回日本臨床外科学会総会, 2023年11月.
23.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 右側結腸癌に対するロボット支援下手術の可能性∼腹腔鏡手術との比較から∼, 第85回日本臨床外科学会総会, 2023年11月.
24.	徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 経肛門アプローチを併用したロボット支援下直腸切除術の有用性, 第85回日本臨床外科学会総会, 2023年11月.
25.	髙須千絵, 西正暁, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 : 上部胃癌に対するロボット支援手術の工夫と成績, 第85回日本臨床外科学会総会, 2023年11月.
26.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 直腸癌手術におけるMRIを用いた骨盤神経描出, 第85回日本臨床外科学会総会, 2023年11月.
27.	柏原秀也, 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 他臓器浸潤を伴う直腸癌に対する経肛門アプローチの有用性, 第61回日本癌治療学会学術集会, 2023年10月.
28.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 : 腹腔鏡下胃癌手術における術前栄養リハビリ介入の有用性, 第61回日本癌治療学会学術集会, 2023年10月.
29.	和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : 胃癌腹膜播種特異的なエクソソーム中miRNAの同定, 第82回日本癌学会学術総会, 2023年9月.
30.	西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 : 上部胃癌に対するロボット支援胃癌手術の定型化-Left-handed LCS and pincer approach-, 第98回中国四国外科学会総会第28回中国四国内視鏡外科研究会, 2023年9月.
31.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 腸内細菌叢の変化からみた減量・代謝改善手術の効果, 第98回中国四国外科学会総会第28回中国四国内視鏡外科研究会, 2023年9月.
32.	吉川幸造, 島田光生, 森根裕二, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 : 大建中湯の消化器疾患における役割, 第98回中国四国外科学会総会第28回中国四国内視鏡外科研究会, 2023年9月.
33.	良元俊昭, 西正暁, 吉川幸造, 中尾寿宏, 徳永卓哉, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 : 青色LEDによる大腸癌由来CAF制御および抗腫瘍効果, 第78回日本消化器外科学会総会, 2023年7月.
34.	和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : エクソソームmiRNAを用いた胃癌腹膜播種の予測, 第78回日本消化器外科学会総会, 2023年7月.
35.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 直腸癌手術におけるMRIを用いた骨盤神経描出, 第78回日本消化器外科学会総会, 2023年7月.
36.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 腹腔鏡下スリーブ状胃切除術後長期効果に影響を及ぼす因子に関する検討, 第78回日本消化器外科学会総会, 2023年7月.
37.	髙須千絵, 西正暁, 和田佑馬, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : 高齢者フレイル胃癌患者における術前栄養・運動介入の意義:短期成績を改善するが長期成績には寄与しない, 第78回日本消化器外科学会総会, 2023年7月.
38.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 : 胃全摘出術における術後パスの有用性―PSMによる解析―, 第78回日本消化器外科学会総会, 2023年7月.
39.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 : 進行胃癌に対するロボット支援手術の有用性, 第78回日本消化器外科学会総会, 2023年7月.
40.	徳永卓哉, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 : 経肛門アプローチを用いた拡大骨盤手術手技, 第78回日本消化器外科学会総会, 2023年7月.
41.	良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 : 大腸癌におけるFrailの意義と免疫栄養指標との関連, 日本外科代謝栄養学会第60回学術集会, 2023年7月.
42.	和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : 胃癌術前における栄養，リハビリ介入の検討, 日本外科代謝栄養学会第60回学術集会, 2023年7月.
43.	野間隆礼, 西正暁, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : 切除不能進行胃癌に対してSOX-NIVO後Conversion手術を施行した2症例, 第44回癌免疫外科研究会, 2023年6月.
44.	髙須千絵, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 : 女性消化器外科医の技術向上とキャリア育成を目指した取り組み, 日本消化器病学会四国支部第119回例会, 2023年6月.
45.	Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto : The Correlation of Immunoscore and Frailty in Colorectal Cancer, 第48回日本外科系連合学会学術集会, Jun. 2023.
46.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 腹腔鏡下スリーブ状胃切除における多職種介入周術期管理の有用性, 第48回日本外科系連合学会学術集会, 2023年6月.
47.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 : 食道胃接合部腺癌に対するロボット支援下手術(経裂孔)の有用性, 第32回日本癌病態治療研究会, 2023年6月.
48.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 : 上部胃癌・食道胃接合部癌に対するロボット支援胃癌手術の手術手技, 第77回手術手技研究会, 2023年5月.
49.	仲須千春, 西正暁, 森根裕二, 良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 和田佑馬, 島田光生 : 青色LEDを用いたCAFの糖代謝に着目した腫瘍免疫制御のメカニズムの解明, 第123回日本外科学会定期学術集会, 2023年4月.
50.	髙須千絵, 西正暁, 和田佑馬, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : 高齢者フレイル胃癌患者における術前栄養・運動リハビリの意義: 短期成績を改善するが長期成績には寄与しない, 第123回日本外科学会定期学術集会, 2023年4月.
51.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 腸脳相関からみたMetabolic surgeryの術後早期血糖抑制効果, 第123回日本外科学会定期学術集会, 2023年4月.
52.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Chie Takasu, Yuuma Wada, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara and Toshiaki Yoshimoto : Utility of robotic surgery for Siewert type II/III adenocarcinoma of esophagogastric junction: transhiatal robotic versus laparoscopic approach, 第123回日本外科学会定期学術集会, Apr. 2023.
53.	徳永卓哉, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 髙橋叡, 島田光生 : 下部直腸癌に対する経肛門アプローチにおける術中ホログラム手術支援の有用性, 第123回日本外科学会定期学術集会, 2023年4月.
54.	良元俊昭, 沖川昌平, 吉川幸造, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 : 青色LED光の腫瘍微小環境に対する効果, 第123回日本外科学会定期学術集会, 2023年4月.
55.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 直腸癌に対するMRIを用いた骨盤神経描出, 第123回日本外科学会定期学術集会, 2023年4月.
56.	吉川幸造, 島田光生, 髙須千絵 : 進行胃癌に対するロボット支援胃切除術の有用性, 第109回日本消化器病学会総会, 2023年4月.
57.	徳永卓哉, 齋藤裕, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介, 島田光生 : 経肛門アプローチを用いた腹腔鏡下側方郭清の手術手技と短期成績 ∼Hologramによるシミュレーションの有用性∼, 第122回日本外科学会定期学術集会, 2023年4月.
58.	和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 島田光生 : 胃癌手術における術前栄養リハビリ介入の有用性, 第95回日本胃癌学会総会, 2023年2月.
59.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 : 上部胃癌・食道胃接合部癌に対するロボット手術の有用性, 第95回日本胃癌学会総会, 2023年2月.
60.	髙須千絵, 西正暁, 和田佑馬, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : 高齢者フレイル胃癌患者における術前栄養・運動介入の意義:短期成績を改善するが長期成績には寄与しない, 第95回日本胃癌学会総会, 2023年2月.
61.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : MISによる胃全摘OrVil法におけるピットフォールとトラブルシューティング, 第95回日本胃癌学会総会, 2023年2月.
62.	徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 下部直腸癌に対するホログラムを駆使した新たな経肛門手術, 第266回徳島医学会学術集会, 2023年2月.
63.	良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 : ロボット支援前立腺全摘後に発症した鼠径ヘルニアに対する腹腔鏡手術症例の検討, 第35回日本内視鏡外科学会総会, 2022年12月.
64.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 直腸癌に対するTaTME併用ロボット支援下直腸切除術(Hybrid robotic surgery)の有用性, 第35回日本内視鏡外科学会総会, 2022年12月.
65.	徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 経肛門側方リンパ節郭清の手技と短期成績 ∼ホログラムシミュレーションの有用性∼, 第35回日本内視鏡外科学会総会, 2022年12月.
66.	髙須千絵, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 : 腹腔鏡下胃切除における6番リンパ節郭清困難性の術前予測, 第35回日本内視鏡外科学会総会, 2022年12月.
67.	西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 : 食道胃接合部癌に対するロボット支援下手術(経裂孔)の工夫, 第35回日本内視鏡外科学会総会, 2022年12月.
68.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 低侵襲胃全摘術後再建における肝臓脱転による視野確保とOrVil法の有用性, 第35回日本内視鏡外科学会総会, 2022年12月.
69.	良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 髙橋叡, 島田光生 : DST吻合における吻合部血流不全のリスク因子および追加切除例の検討, 第84回日本臨床外科学会総会, 2022年11月.
70.	和田佑馬, 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭 : 局所進行直腸癌に対する術前化学放射線療法におけるADC値の有用性, 第84回日本臨床外科学会総会, 2022年11月.
71.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 直腸癌に対するTaTME併用ロボット支援下直腸切除術(Hybrid robotic surgery)の有用性, 第84回日本臨床外科学会総会, 2022年11月.
72.	髙須千絵, 森根裕二, 池本哲也, 齋藤裕, 山田眞一郎, 寺奥大貴, 島田光生 : 大腸癌肝転移における発育形式と予後に関する検討, 第84回日本臨床外科学会総会, 2022年11月.
73.	中尾寿宏, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 腹腔鏡下結腸癌手術における体腔内吻合の短期成績, 第84回日本臨床外科学会総会, 2022年11月.
74.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 胃全摘出術における術後パスの有用性―PSMによる解析―, 第84回日本臨床外科学会総会, 2022年11月.
75.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 和田佑馬, 柏原秀也, 良元俊昭 : 上部胃癌に対するロボット支援胃癌手術の定型化- Left-handed LCS and pincer app roach –, 第84回日本臨床外科学会総会, 2022年11月.
76.	徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 髙橋叡 : 他臓器浸潤を伴う直腸癌に対する経肛門アプローチの有用性, 第84回日本臨床外科学会総会, 2022年11月.
77.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 直腸癌に対するTaTME併用ロボット支援下直腸切除術(Hybrid robotic surgery)の有用性, 第118回日本消化器病学会四国支部例会, 2022年11月.
78.	吉川幸造, 島田光生, 西正暁, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 : 腹腔鏡下胃癌手術における術前栄養リハビリ介入の有用性, 第52回胃外科・術後障害研究会, 2022年11月.
79.	髙須千絵, 仲須千春, 森根裕二, 池本哲也, 齋藤裕, 山田眞一郎, 寺奥大貴, 脇悠平, 島田光生 : Nrf2を基軸とした癌微小環境クロストークによる肝細胞癌Lenvatinib耐性機序解明に関する研究, 第33回日本消化器癌発生学会総会, 2022年11月.
80.	西正暁, 陳術海, 森根裕二, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 : CAFの糖代謝を標的とした治療法の開発 -フラボノイド(EGCGとSudachitin)の可能性-, 第33回日本消化器癌発生学会総会, 2022年11月.
81.	徳永卓哉, 良元俊昭, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 髙橋叡, 島田光生 : 腫瘍関連マクロファージおよび大腸癌に対する青色LEDの効果, 第33回日本消化器癌発生学会総会, 2022年11月.
82.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 大腸癌におけるImmunoscoreとFrailの相関についての検討, 第33回日本消化器癌発生学会総会, 2022年11月.
83.	西正暁, 髙須千絵, 森根裕二, 吉川幸造, 徳永卓哉, 和田佑馬, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 : 漢方とBacterial translocation-大建中湯の消化管疾患に対する多面的効果の検討-, 第35回日本外科感染症学会総会学術集会, 2022年11月.
84.	髙須千絵, 島田光生 : 癌治療におけるDiversity and inclusionを考える, 第60回日本癌治療学会学術集会, 2022年10月.
85.	良元俊昭, 吉川幸造, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 髙橋叡, 島田光生 : 大腸癌手術における予後因子としてのFrailの意義, 第60回日本癌治療学会学術集会, 2022年10月.
86.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 下部直腸癌に対するTaTME併用ロボット支援下直腸切除術の有用性, 第60回日本癌治療学会学術集会, 2022年10月.
87.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 和田佑馬, 良元俊昭 : 上部胃癌に対するロボット手術の工夫 Pincer approach to gastrosplenic ligament, 第60回日本癌治療学会学術集会, 2022年10月.
88.	徳永卓哉, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 髙橋叡, 島田光生 : ハイブリッド側方リンパ節郭清手技と短期成績∼ホログラムシミュレーションの有用性∼, 第60回日本癌治療学会学術集会, 2022年10月.
89.	和田佑馬, 島田光生, 西正暁, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭 : 局所進行直腸癌における術前化学放射線療法においてADC値の有用性, 第60回日本癌治療学会学術集会, 2022年10月.
90.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 髙橋叡 : 大腸癌におけるImmunosoreとFrailの相関, 第60回日本癌治療学会学術集会, 2022年10月.
91.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 胃全摘出術における術後パスの有用性―PSMによる解析―, 第60回日本癌治療学会学術集会, 2022年10月.
92.	柏原秀也, 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 髙須千絵, 和田佑馬, 良元俊昭 : 下部直腸癌に対するTaTME併用ロボット支援下直腸切除術(Hybrid robotic surgery)の有用性, 第77回日本大腸肛門病学会学術集会, 2022年10月.
93.	徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 髙橋叡 : 他臓器浸潤直腸癌に対するTpAPR手術手技, 第77回日本大腸肛門病学会学術集会, 2022年10月.
94.	和田佑馬, 西正暁, 森根裕二, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭, 島田光生 : 癌関連線維芽細胞における糖代謝に着目した治療法の可能性, 第81回日本癌学会学術総会, 2022年9月.
95.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 下部直腸癌に対するTaTME併用ロボット支援下直腸切除術(Hybrid robotic surgery)の有用性, 第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, 2022年9月.
96.	西正暁, 島田光生, 吉川幸造, 和田佑馬, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 : 上部胃癌におけるロボット支援胃癌手術の工夫, 第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, 2022年9月.
97.	髙須千絵, 吉川幸造, 中尾寿宏, 西正暁, 徳永卓哉, 柏原秀也, 和田佑馬, 良元俊昭, 髙橋叡, 島田光生 : 腹腔鏡下胃切除における幽門下リンパ郭清困難性の術前評価, 第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, 2022年9月.
98.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 腹腔鏡下結腸癌手術における体腔内吻合の短期成績, 第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, 2022年9月.
99.	西正暁, 陳術海, 森根裕二, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 : CAFの糖代謝を標的とした治療法の開発-フラボノイド(EGCGとSudachitin)の可能性-, 第265回徳島医学会学術集会, 2022年7月.
100.	髙須千絵, 仲須千春, 森根裕二, 池本哲也, 齋藤裕, 山田眞一郎, 寺奥大貴, 濵田康弘, 沖川昌平, 島田光生 : 肝細胞癌におけるmiRNA-132, 142-5pを介したLenvatinib耐性機序の検討, 第77回日本消化器外科学会総会, 2022年7月.
101.	岩川陽介, 西正暁, 和田佑馬, 島田光生, 吉川幸造, 中尾寿宏, 徳永卓哉, 髙須千絵, 柏原秀也, 良元俊昭 : 胃GISTに対するLECSの検討 -腫瘍径5㎝以上に対するLECS-, 第77回日本消化器外科学会総会, 2022年7月.
102.	徳永卓哉, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 : Hologramによるシミュレーションを用いた経肛門的側方リンパ節郭清, 第77回日本消化器外科学会総会, 2022年7月.
103.	良元俊昭, 吉川幸造, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 沖川昌平, 島田光生 : 大腸癌腫瘍関連マクロファージに対する青色LEDの効果, 第77回日本消化器外科学会総会, 2022年7月.
104.	和田佑馬, 島田光生, 西正暁, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭, 岩川陽介 : 腹腔鏡下胃癌手術における術前栄養リハビリ介入の有用性, 第77回日本消化器外科学会総会, 2022年7月.
105.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子 : 腹腔鏡下スリーブ状胃切除術後長期効果に影響を及ぼす因子に関する検討, 第77回日本消化器外科学会総会, 2022年7月.
106.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 和田佑馬, 山下祥子 : 上部胃癌に対するロボット支援胃癌手術の工夫, 第77回日本消化器外科学会総会, 2022年7月.
107.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子 : 胃癌播種診断におけるCTスコアリングシステムを用いた診断率改善の試み, 第77回日本消化器外科学会総会, 2022年7月.
108.	髙須千絵, 仲須千春, 森根裕二, 池本哲也, 齋藤裕, 山田眞一郎, 寺奥大貴, 沖川昌平, 島田光生 : 肝細胞癌におけるmiRNA-X,Yを介したLenvatinib耐性機序の検討, 第26回日本肝がん分子標的治療研究会, 2022年6月.
109.	徳永卓哉, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 : 直腸癌に対するTaTME併用ロボット支援下直腸切除術の有用性, 第31回日本癌病態治療研究会, 2022年6月.
110.	和田佑馬, 吉川幸造, 西正暁, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭, 島田光生 : 進行胃癌に対するロボット支援下胃切除術の有用性, 第117回例会日本消化器病学会四国支部, 2022年6月.
111.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子 : 進行胃癌に対するロボット支援胃切除術の有用性とピットフォール, 第47回日本外科系連合学会学術集会, 2022年6月.
112.	Toshiaki Yoshimoto, Takuya Tokunaga, Yu Saitou, Hideya Kashihara, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Yuuma Wada, 山下祥子, 岩川陽介 and Mitsuo Shimada : Intraoperative holographic image-guided lateral pelvic lymph node dissection in a transanal approach for rectal cancer, CARS 2022, Jun. 2022.
113.	徳永卓哉, 杉本真樹, 齋藤裕, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 : 経肛門アプローチ併用ハイブリッド側方リンパ節郭清に対するホログラムの有用性, 第31回日本コンピュータ外科学会大会, 2022年6月.
114.	Yuuma Wada, Masaaki Nishi, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto and Mitsuo Shimada : Apparent diffusion coefficient measurements predict survival outcomes after neoadjuvant chemoradiotherapy in locally advanced rectal cancer, 第67回国際外科学会日本部会総会, Jun. 2022.
115.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 : ロボット胃癌手術における工夫 -Left handed LCS techniqueとPincer approach for gastro-splenic ligament-, 第76回手術手技研究会, 2022年5月.
116.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 術前抗がん剤治療を行った進行胃癌に対する低侵襲手術の有用性, 第122回日本外科学会定期学術集会, 2022年4月.
117.	徳永卓哉, 齋藤裕, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介, 島田光生 : 経肛門アプローチを用いた腹腔鏡下側方郭清の手術手技と短期成績∼Hologramによるシミュレーションの有用性∼, 第122回日本外科学会定期学術集会, 2022年4月.
118.	松崎慶仁, 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 : ALS患者の胃癌2切除例, 第122回日本外科学会定期学術集会, 2022年4月.
119.	和田佑馬, 西正暁, 陳術海, 森根裕二, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 良元俊昭, 山下祥子, 岩川陽介, 島田光生 : 癌関連線維芽細胞の糖代謝を標的とした治療法の開発, 第122回日本外科学会定期学術集会, 2022年4月.
120.	髙須千絵, 森根裕二, 池本哲也, 齋藤裕, 山田眞一郎, 寺奥大貴, 沖川昌平, 島田光生 : 間葉系幹細胞から肝細胞様細胞の誘導におけるNrf2の働きに関する検討, 第122回日本外科学会定期学術集会, 2022年4月.
121.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 : 大腸癌におけるImmunoscoreとフレイルの検討, 第122回日本外科学会定期学術集会, 2022年4月.
122.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 直腸癌に対するTaTME併用ロボット支援下直腸切除術の有用性 - TaTME併用腹腔鏡下直腸切除術との比較から –, 第122回日本外科学会定期学術集会, 2022年4月.
123.	武原悠花子, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 : 腹腔鏡下スリーブ状胃切除における多職種介入術前減量プログラムの有用, 第122回日本外科学会定期学術集会, 2022年4月.
124.	山下祥子, 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 岩川陽介 : 直腸癌の放射線化学療法における肥満細胞の役割, 第122回日本外科学会定期学術集会, 2022年4月.
125.	沖川昌平, 柏原秀也, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 森根裕二 : Duodenal-jejunal bypassの術後早期血糖抑制効果に関する検討, 第122回日本外科学会定期学術集会, 2022年4月.
126.	良元俊昭, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 沖川昌平, 山下祥子, 岩川陽介, 島田光生 : 青色LEDの腫瘍関連マクロファージ(TAM)および大腸癌細胞に対する効果, 第122回日本外科学会定期学術集会, 2022年4月.
127.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 山下祥子 : ロボット支援胃癌手術の短期・長期成績-ロボットvs腹腔鏡:プロペンシティスコアマッチ解析-, 第122回日本外科学会定期学術集会, 2022年4月.
128.	髙須千絵, 吉川幸造, 中尾寿宏, 西正暁, 徳永卓哉, 柏原秀也, 和田佑馬, 良元俊昭, 山下祥子 : 腹腔鏡下胃切除における幽門下リンパ郭清困難性の術前評価, 第94回日本胃癌学会総会, 2022年3月.
129.	和田佑馬, 西正暁, 島田光生, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 山下祥子, 岩川陽介 : 高齢者におけるFrailtyの臨床的意義, 第94回日本胃癌学会総会, 2022年3月.
130.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Chie Takasu, Yuuma Wada, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Shoko Yamashita : Propensity score-matched analysis of the short-and long-term outcomes of RG vs. LG, 第94回日本胃癌学会総会, Mar. 2022.
131.	Kouzou Yoshikawa, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto and Shoko Yamashita : The usefulness of the minimal invasive surgery for advanced gastric cancer with preoperative chemotherapy, 第94回日本胃癌学会総会, Mar. 2022.
132.	髙須千絵, 森根裕二, 吉川幸造, 中尾寿宏, 西正暁, 徳永卓哉, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 : 腸管Microbiome解析からみた大建中湯の消化管疾患に対する多面的効果の検討, 第18回日本消化管学会総会学術集会(GI Week 2022), 2022年2月.
133.	良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 山下祥子, 岩川陽介, 島田光生 : ロボット支援下前立腺全摘術後に発症した鼠径ヘルニアの検討, 第34回日本内視鏡外科学会総会, 2021年12月.
134.	和田佑馬, 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭, 山下祥子, 岩川陽介 : 腹腔鏡・ロボット支援下胃癌手術のトレーニングプログラムの構築, 第34回日本内視鏡外科学会総会, 2021年12月.
135.	髙須千絵, 吉川幸造, 中尾寿宏, 徳永卓哉, 柏原秀也, 和田佑馬, 良元俊昭, 山下祥子, 島田光生 : 腹腔鏡下胃切除における幽門下リンパ郭清困難性の術前評価, 第34回日本内視鏡外科学会総会, 2021年12月.
136.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : NASHに対する新たな治療アプローチとしての腹腔鏡下スリーブ状胃切除術, 第34回日本内視鏡外科学会総会, 2021年12月.
137.	西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 : ロボット支援胃癌手術の有用性, 第34回日本内視鏡外科学会総会, 2021年12月.
138.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 : 横行結腸・脾弯曲部・下行結腸癌における血管走行と腹腔鏡下手術手技に関する検討, 第34回日本内視鏡外科学会総会, 2021年12月.
139.	徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 : 他臓器合併切除を要する直腸癌に対するTrasaperineal abdominoperineal resection, 第34回日本内視鏡外科学会総会, 2021年12月.
140.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 腹腔鏡下スリーブ状胃切除における多職種介入周術期管理の有用性(WS5-2), 第34回日本内視鏡外科学会総会, 2021年12月.
141.	吉川幸造, 島田光生, 中尾寿宏, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 : ロボット支援胃癌手術におけるLeft hand LCS techniqueを用いた定型化への取り組み(WS6-7), 第34回日本内視鏡外科学会総会, 2021年12月.
142.	良元俊昭, 沖川昌平, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 山下祥子, 岩川陽介, 島田光生 : 青色LEDの癌関連線維芽細胞および大腸癌に対する効果, 第32回日本消化器癌発生学会総会, 2021年11月.
143.	和田佑馬, 西正暁, 島田光生, 山下祥子, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 良元俊昭, 岩川陽介 : 直腸癌の放射線化学療法における肥満細胞の役割, 第32回日本消化器癌発生学会総会, 2021年11月.
144.	西正暁, 島田光生, 陳述海, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 : EGCGがCAFの糖代謝を標的とし，腫瘍悪性度を抑制する, 第32回日本消化器癌発生学会総会, 2021年11月.
145.	髙須千絵, 高露萍, 山田眞一郎, 森根裕二, 池本哲也, 齋藤裕, 沖川昌平, 宮崎克己, 島田光生 : Nrf2を介した微小環境クロストークによる肝細胞癌薬剤耐性機序解明に関する研究, 第32回日本消化器癌発生学会総会, 2021年11月.
146.	徳永卓哉, 杉本真樹, 齋藤裕, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介, 島田光生 : 直腸癌に対する経肛門的アプローチにおけるホログラムと尿道造影を併用した術中ナビゲーション, 第30回日本コンピュータ外科学会大会, 2021年11月.
147.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 山下祥子, 岩川陽介 : ロボット支援胃切除の有用性-Robotic Versus Laparoscopic Gastrectomy: Propensi ty-Matched Analysis.-, 第116回日本消化器病学会四国支部例会, 2021年11月.
148.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 : taTMEの手術手技と治療成績, 第116回日本消化器病学会四国支部例会, 2021年11月.
149.	岩川陽介, 西正暁, 島田光生, 吉川幸造, 中尾寿宏, 徳永卓哉, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭, 山下祥子 : 胃原発の未分化型多形肉腫の1例, 第83回日本臨床外科学会総会, 2021年11月.
150.	山下祥子, 西正暁, 良元俊昭, 和田佑馬, 柏原秀也, 髙須千絵, 中尾寿宏, 徳永卓哉, 吉川幸造, 常山幸一, 島田光生 : Osteoclast-like giant cellを伴うhamartomatous inverted polypから発生したリンパ球浸潤胃癌の一例, 第83回日本臨床外科学会総会, 2021年11月.
151.	沖川昌平, 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介, 森根裕二 : Duodenal-jejunal bypassの術後早期血糖抑制効果に関する検討, 第83回日本臨床外科学会総会, 2021年11月.
152.	良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 山下祥子, 岩川陽介, 島田光生 : 大腸癌予後因子としてのFrailの意義, 第83回日本臨床外科学会総会, 2021年11月.
153.	髙須千絵, 森根裕二, 池本哲也, 齋藤裕, 山田眞一郎, 寺奥大貴, 島田光生 : 大腸癌肝転移における免疫逃避機構の働き, 第83回日本臨床外科学会総会, 2021年11月.
154.	西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 : ロボット支援胃癌手術の標準化, 第83回日本臨床外科学会総会, 2021年11月.
155.	徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 : 直腸切断術に対するTransperineal approachの有用性, 第83回日本臨床外科学会総会, 2021年11月.
156.	和田佑馬, 島田光生, 柏原秀也, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 良元俊昭, 山下祥子, 岩川陽介 : 腹腔鏡下胃癌手術における術前減量プログラムの有用性, 第83回日本臨床外科学会総会, 2021年11月.
157.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 良元俊昭 : 経肛門的内視鏡下直腸間膜切除術TaTME併用による安全なロボット支援下直腸切除術の導入, 第83回日本臨床外科学会総会, 2021年11月.
158.	中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 山下祥子, 岩川陽介 : 横行結腸癌における中結腸動脈の分岐からみた腹腔鏡下手術手技，治療成績, 第83回日本臨床外科学会総会, 2021年11月.
159.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子 : 腹腔鏡下胃全摘OrVil法におけるピットフォールとトラブルシューティング, 第83回日本臨床外科学会総会, 2021年11月.
160.	髙須千絵, 島田光生, 徳永卓哉, 中尾寿宏, 柏原秀也, 和田佑馬, 良元俊昭, 山下祥子, 仲須千春 : 地方だからこそ発信できるインクルージョンを目指した働き方改革, 第83回日本臨床外科学会総会, 2021年11月.
161.	髙須千絵, 山下祥子, 島田光生 : オンライン時代は女性医師キャリア形成の追い風となる, JDDW 2021, 2021年11月.
162.	吉川幸造, 島田光生, 東島潤, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 江藤祥平, 良元俊昭 : ロボット時代の正確な腹膜播種診断に向けての胃癌Staging laparoscopyの有用性, JDDW 2021, 2021年11月.
163.	和田佑馬, 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭, 山下祥子 : 外科手術におけるFrailtyの重要性, 第51回胃外科・術後障害研究会, 2021年11月.
164.	良元俊昭, 吉川幸造, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 岩川陽介, 島田光生 : DST吻合における吻合部血流不全のリスク因子:追加切除例の検討, 第59回日本癌治療学会学術集会, 2021年10月.
165.	西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子 : 高齢者胃癌患者における外科手術の意義-Frailtyの重要性-, 第59回日本癌治療学会学術集会, 2021年10月.
166.	徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 : 当科におけるTaTME手術手技と治療成績, 第59回日本癌治療学会学術集会, 2021年10月.
167.	柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 : 腹腔鏡下胃・大腸癌手術における多職種介入術前減量プログラムの有用性, 第59回日本癌治療学会学術集会, 2021年10月.
168.	吉川幸造, 島田光生, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : 進行胃癌に対するロボット手術の有用性, 第59回日本癌治療学会学術集会, 2021年10月.
169.	和田佑馬, 島田光生, 柏原秀也, 吉川幸造, 中尾寿宏, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 山下祥子, 岩川陽介, 濵田康弘 : 肥満外科手術における術前NLRの有用性, 第27回外科侵襲とサイトカイン研究会, 2021年10月.
170.	Masaaki Nishi, Ryosuke Miyamoto, Kouzou Yoshikawa, Chie Takasu, Yuishin Izumi and Mitsuo Shimada : Robot-assisted total gastrectomy for gastric cancer in a patient with amyotrophic lateral sclerosis receiving long-term tracheostomy invasive ventilation, PACTALS 2021 NAGOYA, Sep. 2021.
171.	西正暁, 島田光生, 陳述海, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 : 癌関連線維芽細胞の糖代謝を標的とした治療法の開発, 第263回徳島医学会学術集会(令和3年度夏期), 2021年8月.
172.	沖川昌平, 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 森根裕二 : Duodenal-jejunal bypassの術後早期血糖抑制効果に関する検討, 第76回日本消化器外科学会総会, 2021年7月.
173.	良元俊昭, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 沖川昌平, 島田光生 : 青色LEDの癌関連線維芽細胞および大腸癌細胞に対する効果, 第76回日本消化器外科学会総会, 2021年7月.
174.	吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 : 進行胃癌に対するロボット支援胃切除術の有用性, 第76回日本消化器外科学会総会, 2021年7月.
175.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Shohei Eto and Toshiaki Yoshimoto : Feasibility of hybrid robotic rectal surgery with TaTME for lower rectal cancer, 第76回日本消化器外科学会総会, Jul. 2021.
176.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 江藤祥平 : 高齢者胃癌に対するFrailityの意義, 第76回日本消化器外科学会総会, 2021年7月.
177.	髙須千絵, 吉川幸造, 東島潤, 西正暁, 徳永卓哉, 柏原秀也, 江藤祥平, 良元俊昭, 島田光生 : 地方外科の実情と今後のリーダー育成に向けて, 第76回日本消化器外科学会総会, 2021年7月.
178.	徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 : 直腸癌に対するTaTMEの手術手技と治療成績, 第76回日本消化器外科学会総会, 2021年7月.
179.	良元俊昭, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 沖川昌平, 山下祥子, 岩川陽介, 仲須千春 : 青色LEDの癌関連線維芽細胞および大腸癌細胞に対する効果, 第115回日本消化器病学会四国支部例会, 2021年6月.
180.	吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : 腹腔鏡下胃・大腸癌手術における術前減量プログラムは短期成績改善に寄与する, 第12回日本臨床栄養代謝学会首都圏支部会学術集会, 2021年5月.
181.	吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 良元俊昭 : 進行胃癌に対するロボット支援下胃切除術の有用性と安全性, 第75回手術手技研究会, 2021年5月.
182.	良元俊昭, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 島田光生 : 大腸癌予後因子としてのFrailの意義とメカニズムの検討, 第107回日本消化器病学会総会, 2021年4月.
183.	髙須千絵, 柏原秀也, 島田光生 : Metabolic surgeryによる NASH治療, 第107回日本消化器病学会総会, 2021年4月.
184.	仲須千春, 西正暁, 島田光生, 吉川幸造, 髙須千絵, 徳永卓哉, 柏原秀也, 和泉唯信, 宮本亮介 : 胃癌を発症したロックドイン状態のALS患者に対してロボット支援下胃全摘, 第121回日本外科学会定期学術集会, 2021年4月.
185.	東島潤, 島田光生, 沖川昌平, 良元俊昭, 江藤祥平, 髙須千絵, 柏原秀也, 西正暁, 徳永卓哉, 吉川幸造 : 骨髄由来免疫抑制細胞を標的とした放射線治療抵抗性の制御メカニズムの解明, 第121回日本外科学会定期学術集会, 2021年4月.
186.	良元俊昭, 島田光生, 森根裕二, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 沖川昌平 : 大腸癌および腫瘍微小環境に対する青色LEDの効果, 第121回日本外科学会定期学術集会, 2021年4月.
187.	江藤祥平, 吉川幸造, 良元俊昭, 髙須千絵, 柏原秀也, 西正暁, 中尾寿宏, 徳永卓哉, 東島潤, 岩田貴, 島田光生 : ロボット支援腹腔鏡下前立腺切除術後の鼠径ヘルニア症例に対する治療戦略, 第121回日本外科学会定期学術集会, 2021年4月.
188.	髙須千絵, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 江藤祥平, 良元俊昭, 島田光生 : 転移性肝癌におけるstromal PD-L1発現の意義, 第121回日本外科学会定期学術集会, 2021年4月.
189.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 江藤祥平, 良元俊昭 : NASHに対する新たな治療アプローチとしてのmetabolic surgeryの可能性, 第121回日本外科学会定期学術集会, 2021年4月.
190.	徳永卓哉, 島田光生, 齋藤裕, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭, 杉本真樹 : ホログラムと術中尿道造影を駆使した経会陰的直腸切断術(TpAPR), 第121回日本外科学会定期学術集会, 2021年4月.
191.	Toshiaki Yoshimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yukako Takehara, K Yamaguchi, M Takahashi, Hiro-omi Kanayama and Mitsuo Shimada : Surgical approach for inguinal hernia following robot-assisted radical prostatectomy, 第33回日本内視鏡外科学会, Mar. 2021.
192.	Takuya Tokunaga, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto and Yukako Takehara : The Usefulness of Intraoperative Urethrography for Avoiding Urethral Injury in TpTME, 第33回日本内視鏡外科学会, Mar. 2021.
193.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto : Usefulness of a left handed LCS technique for robotic gastrectomy, 第33回日本内視鏡外科学会, Mar. 2021.
194.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto : The usefulness of the OrVil method in LATG, 第33回日本内視鏡外科学会, Mar. 2021.
195.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Toshiaki Yoshimoto : Usefulness of preoperative NLR as a predictive marker of DM remission in sleeve gastrectomy, 第33回日本内視鏡外科学会, Mar. 2021.
196.	吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 : 腹腔鏡下胃全摘出術の食道空腸吻合法におけるOrVil法の有用性, 第33回日本内視鏡外科学会, 2021年3月.
197.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Shohei Eto, Toshiaki Yoshimoto and Yuuma Wada : Robotic Versus Laparoscopic Gastrectomy: Propensity-Matched Analysis, 第93回日本胃癌学会総会, Mar. 2021.
198.	吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 : 地方におけるロボット手術の定型化への試み, 第93回日本胃癌学会総会, 2021年3月.
199.	柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭 : 肥満外科における術後体重減少・糖尿病寛解予測因子としてのNLRの有用性, 第57回日本外科代謝栄養学会学術集会, 2020年12月.
200.	良元俊昭, 徳永卓哉, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 武原悠花子, 島田光生 : TaTMEを安全に行うために∼術中尿道造影の有用性∼, 第45回日本外科系連合学会学術集会, 2020年12月.
201.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 髙須千絵, 柏原秀也, 良元俊昭 : 鏡視下胃癌手術のトレーニングプログラムの構築Stepwise training programの有用性, 第45回日本外科系連合学会学術集会, 2020年12月.
202.	武原悠花子, 徳永卓哉, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 島田光生 : DST吻合における吻合部血流不全域のリスク因子:追加切除例の検討から, 第75回日本消化器外科学会総会, 2020年12月.
203.	髙須千絵, 西正暁, 吉川幸造, 宮谷知彦, 徳永卓哉, 柏原秀也, 良元俊昭, 武原悠花子, 島田光生 : 直腸癌CRTにおける腫瘍のIDO発現の意義, 第75回日本消化器外科学会総会, 2020年12月.
204.	吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子 : 進行胃癌に対するロボット支援下胃切除術の有用性, 第75回日本消化器外科学会総会, 2020年12月.
205.	柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 髙須千絵, 良元俊昭, 武原悠花子 : 肥満外科における術後体重減少・糖尿病寛解予測因子としてのNLRの有用性, 第75回日本消化器外科学会総会, 2020年12月.
206.	西正暁, 島田光生, 吉川幸造, 宮谷知彦, 柏原秀也, 髙須千絵, 吉川雅登, 良元俊昭, 武原悠花子 : ロボット支援下胃癌手術におけるLeft handed LCS techniqueの有用性, 第75回日本消化器外科学会総会, 2020年12月.
207.	徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 吉川雅登, 良元俊昭, 武原悠花子 : TpTMEにおける前壁側剥離の工夫 ∼術中尿道造影の有用性∼, 第75回日本消化器外科学会総会, 2020年12月.
208.	良元俊昭, 島田光生, 森根裕二, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 沖川昌平 : 青色LEDによる大腸癌の光受容体をターゲットとする治療法の開発, 第31回日本消化器癌発生学会総会, 2020年11月.
209.	江藤祥平, 西正暁, 良元俊昭, 髙須千絵, 柏原秀也, 徳永卓哉, 中尾寿宏, 東島潤, 吉川幸造, 島田光生 : 下部進行直腸癌におけるCRT後のリンパ球CRP比(LCR)は予後不良因子となる, 第31回日本消化器癌発生学会総会, 2020年11月.
210.	Chie Takasu, Shoko Iwahashi and Mitsuo Shimada : 憧れの消化器外科専門医・スペシャリストを目指して, JDDW2020, Nov. 2020.
211.	Takuya Tokunaga, Mitsuo Shimada, Jun Higashijima, Kouzou Yoshikawa, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Shohei Eto and Toshiaki Yoshimoto : The Usefulness of Intraoperative Urethrography in Transperineal total Mesorectal Excision, JDDW2020, Nov. 2020.
212.	東島潤, 良元俊昭, 江藤祥平, 柏原秀也, 髙須千絵, 西正暁, 徳永卓哉, 吉川幸造, 島田光生 : ICG蛍光法を用いた大腸癌手術成績向上のための戦略, 第82回日本臨床外科学会総会, 2020年10月.
213.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 : ロボット支援胃癌手術の定型化-Left Handed LCS techniqueの有用性-, 第82回日本臨床外科学会総会, 2020年10月.
214.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 江藤祥平, 良元俊昭 : 肥満患者に対する術後合併症の回避を目指した術前減量プログラムの有用性, 第82回日本臨床外科学会総会, 2020年10月.
215.	徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 : 術中尿道造影を併用したTpAPR手術手技, 第82回日本臨床外科学会総会, 2020年10月.
216.	吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 : 腹腔鏡下胃全摘出術の食道空腸吻合法におけるOrVil法―Tension free methodの有用性―, 第82回日本臨床外科学会総会, 2020年10月.
217.	吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : Bevacizumab使用中の消化器外科手術に関する検討, 第56回日本腹部救急医学会総会, 2020年10月.
218.	吉川幸造, 島田光生, 徳永卓哉, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : ロボット支援下胃切除術の安全な導入と定型化, 第106回日本消化器病学会総会, 2020年8月.
219.	良元俊昭, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 島田光生 : 血液透析患者に対する胃癌手術症例における予後因子の検討, 第92回日本胃癌学会総会, 2020年7月.
220.	吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : 腹腔鏡下胃全摘OrVil法におけるピットフォールとトラブルシューティング, 第92回日本胃癌学会総会, 2020年7月.
221.	西正暁, 島田光生, 吉川幸造, 徳永卓哉, 柏原秀也, 髙須千絵 : Left handed approach によるロボット支援下胃癌手術の有用性, 第92回日本胃癌学会総会, 2020年7月.
222.	武原悠花子, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 島田光生 : 大腸癌におけるFrailの意義とメカニズムの検討, 第53回制癌剤適応研究会, 2020年2月.
223.	良元俊昭, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 武原悠花子, 島田光生 : Bevacizumab使用中の消化器外科手術に関する検討, 第53回制癌剤適応研究会, 2020年2月.
224.	柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵 : 大腸癌のsidednessからみた腫瘍免疫, 第53回制癌剤適応研究会, 2020年2月.
225.	徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子 : 局所進行直腸癌に対する分子標的薬を加えた術前化学放射線療法の効果と感受性予測, 第53回制癌剤適応研究会, 2020年2月.
226.	柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 武原悠花子 : 経肛門的内視鏡下直腸間膜切除術TaTME併用ロボット支援下直腸切除術の有用性, 第34回四国内視鏡外科研究会, 2020年2月.
227.	吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : ロボット支援下胃切除術の安全な導入と定型化, 第34回四国内視鏡外科研究会, 2020年2月.
228.	良元俊昭, 武原悠花子, 柏原秀也, 髙須千絵, 西正暁, 徳永卓哉, 宮谷知彦, 吉川幸造, 森根裕二, 島田光生 : LED光による新たな癌制御法の開発, 第260回徳島医学会学術集会, 2020年2月.
229.	柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 武原悠花子, 濵田康弘 : 非アルコール性脂肪肝炎(NASH)に対する新たな外科治療の開発, 第260回徳島医学会学術集会, 2020年2月.
230.	柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭 : Stepwise trainingとTaTME併用による安全なロボット支援下直腸切除術の導入, 第32回日本内視鏡外科学会総会, 2019年12月.
231.	西正暁, 島田光生, 吉川幸造, 徳永卓哉, 宮谷知彦, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子 : ロボット支援胃癌手術におけるLeft handed approach の有用性, 第32回日本内視鏡外科学会総会, 2019年12月.
232.	徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子 : TpTMEを安全に行うために ∼前壁剥離時の術中尿道造影の有用性∼, 第32回日本内視鏡外科学会総会, 2019年12月.
233.	吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : スリーブ状胃切除における多職種介入術前減量入院の効果, 第32回日本内視鏡外科学会総会, 2019年12月.
234.	Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Toshiaki Yoshimoto : The significance of metabolic surgery in the treatment for NASH, JDDW2019, Nov. 2019.
235.	武原悠花子, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : 大腸切除術における他職種介入SSI対策チームの有用性, 第81回日本臨床外科学会総会, 2019年11月.
236.	柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 武原悠花子 : 直腸癌手術におけるICG蛍光法・サーモグラフィによる血流評価を用いた縫合不全回避対策, 第81回日本臨床外科学会総会, 2019年11月.
237.	西正暁, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 髙須千絵, 良元俊昭, 武原悠花子 : ロボット支援下胃癌手術におけるLeft handed approach の有用性, 第81回日本臨床外科学会総会, 2019年11月.
238.	良元俊昭, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 武原悠花子, 森根裕二, 島田光生 : 光受容体Opsin3をターゲットとした青色LEDの大腸癌抑制効果, 第81回日本臨床外科学会総会, 2019年11月.
239.	吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : 地方から発信する腹腔鏡技術認定医取得への教育プログラム, 第81回日本臨床外科学会総会, 2019年11月.
240.	良元俊昭, 西正暁, 武原悠花子, 柏原秀也, 髙須千絵, 徳永卓哉, 宮谷知彦, 吉川幸造, 島田光生 : 大腸癌のsidednessからみた腫瘍免疫, 第30回日本消化器癌発生学会総会, 2019年11月.
241.	徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子, 宮崎克己 : 下部直腸癌に対する経肛門的アプローチ(TaTME)∼術中尿道造影の有用性∼, 第112回日本消化器病学会四国支部例会, 2019年11月.
242.	吉川幸造, 島田光生, 柏原秀也, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 濵田康弘, 吉田守美子 : スリーブ状胃切除における術前減量入院の効果とNLRによる術後減量効果予測, 第40回日本肥満学会第37回日本肥満症治療学会学術集会, 2019年11月.
243.	武原悠花子, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : 腹腔鏡下胃切除術における術前減量プログラムの有用性, 第40回日本肥満学会第37回日本肥満症治療学会学術集会, 2019年11月.
244.	柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭 : NASH治療におけるMetabolic surgeryの意義, 第40回日本肥満学会第37回日本肥満症治療学会学術集会, 2019年11月.
245.	吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : 胃癌に対するロボット手術の有用性, 第57回日本癌治療学会学術集会, 2019年10月.
246.	良元俊昭, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 武原悠花子, 森根裕二, 島田光生 : 光受容体Opn3を介した青色LEDの大腸癌抑制効果, 第57回日本癌治療学会学術集会, 2019年10月.
247.	良元俊昭, 島田光生, 西正暁, 柏原秀也, 髙須千絵, 徳永卓哉, 宮谷知彦, 吉川幸造 : 光受容体Opn3を介した青色LED光の大腸癌抑制効果, 第78回日本癌学会学術総会, 2019年9月.
248.	武原悠花子, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 良元俊昭 : GISTとの鑑別を要したデスモイド型線維腺腫症の一例, 第71回日本消化器画像診断研究会, 2019年9月.
249.	良元俊昭, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 武原悠花子 : 術前診断が困難であった成人小腸重複腸管の1例, 第71回日本消化器画像診断研究会, 2019年9月.
250.	良元俊昭, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 島田光生 : Bevacizumab使用中の消化器外科手術に関する検討, 第74回日本消化器外科学会総会, 2019年7月.
251.	西正暁, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 : Left handed approach によるロボット支援下胃癌手術, 第74回日本消化器外科学会総会, 2019年7月.
252.	岩田貴, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : VR+AR実習は学生の腹腔鏡模擬手術実習における局所解剖理解に有用である, 第74回日本消化器外科学会総会, 2019年7月.
253.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 濵田康弘 : スリーブ状胃切除における術前NLRと糖尿病改善についての検討, 第74回日本消化器外科学会総会, 2019年7月.
254.	髙須千絵, 島田光生, 岩田貴, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 良元俊昭 : 女性消化器外科医の技術向上とキャリア育成を目指した取り組み, 第74回日本消化器外科学会総会, 2019年7月.
255.	徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : Urethrography navigationを用いたTpTME手術手技, 第74回日本消化器外科学会総会, 2019年7月.
256.	吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : 腹腔鏡下胃全摘出術の食道空腸吻合法におけるOrVil法の有用性―合併症ゼロを目指した工夫―, 第74回日本消化器外科学会総会, 2019年7月.
257.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 濵田康弘 : スリーブ状胃切除における多職種介入術前減量入院の効果とNLRによる術後減量効果, 日本外科代謝栄養学会第56回学術集会, 2019年7月.
258.	西正暁, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 柏原秀也, 髙須千絵, 良元俊昭 : Left handed approachによるロボット支援下胃癌手術, 第111回日本消化器病学会四国支部例会, 2019年6月.
259.	髙須千絵, 島田光生, 吉川幸造 : 大健中湯は小腸パイエル版のPD-1発現を介してバクテリアルトランスロケーション発症を予防する可能性がある, 第70回日本東洋医学会学術総会, 2019年6月.
260.	吉川幸造, 島田光生, 髙須千絵 : 腹腔鏡下胃切除後ERAS(enhanced recovery after surgery)における大建中湯の有用性, 第70回日本東洋医学会学術総会, 2019年6月.
261.	吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 岩橋祥子 : 大腸癌手術における周術期VTE予防マネジメント, 第44回日本外科系連合学会学術集会, 2019年6月.
262.	岩田貴, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : 学生の腹腔鏡模擬手術実習における局所解剖理解に対するVR+ARの有用性について, 第44回日本外科系連合学会学術集会, 2019年6月.
263.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵 : ガーゼ剥離と膨潤TAPPを用いた腹腔鏡手術教育システムの有効性, 第17回日本ヘルニア学会学術集会, 2019年5月.
264.	徳永卓哉, 島田光生, 東島潤, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : TpTMEにおける前壁剥離時の術中尿道造影の有用性, 第73回手術手技研究会, 2019年5月.
265.	仲須千春, 西正暁, 島田光生, 岩橋祥子, 池本哲也, 東島潤, 宮谷知彦, 徳永卓哉, 柏原秀也, 髙須千絵, 良元俊昭 : 大腸癌手術における周術期VTE予防マネジメント, 第119回日本外科学会定期学術集会, 2019年4月.
266.	徳永卓哉, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : 直腸切断術におけるTaTMEの工夫 ∼尿道損傷回避のための術中尿道造影の有用性∼, 第119回日本外科学会定期学術集会, 2019年4月.
267.	東島潤, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : 側方転移を有する進行下部直腸癌に対する術前CRT+側方郭清の功罪, 第119回日本外科学会定期学術集会, 2019年4月.
268.	宮谷知彦, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 太田昇吾, 岩橋祥子 : 直腸癌手術におけるICG蛍光法による血流評価の有用性と定量化, 第119回日本外科学会定期学術集会, 2019年4月.
269.	吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : Step-wise trainingシステムによる安全なロボット支援胃切除導入の取り組み, 第119回日本外科学会定期学術集会, 2019年4月.
270.	髙須千絵, 森根裕二, 居村暁, 池本哲也, 岩橋衆一, 齋藤裕, 山田眞一郎, 和田佑馬, 良元俊昭, 太田昇吾, 島田光生 : 大腸癌肝転移における免疫逃避機構は原発巣と異なる可能性がある, 第119回日本外科学会定期学術集会, 2019年4月.
271.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 濵田康弘 : スリーブ状胃切除における多職種介入術前減量入院の効果とNLRによる術後減量効果予測, 第119回日本外科学会定期学術集会, 2019年4月.
272.	西正暁, 島田光生, 髙須千絵, 東島潤, 吉川幸造, 宮谷知彦, 徳永卓哉, 柏原秀也 : 大腸癌におけるsidednessからみた腫瘍免疫機構, 第119回日本外科学会定期学術集会, 2019年4月.
273.	岩田貴, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : 学生の腹腔鏡実習における局所解剖理解のためのVR実習の検討, 第119回日本外科学会定期学術集会, 2019年4月.
274.	良元俊昭, 森根裕二, 居村暁, 池本哲也, 岩橋衆一, 齋藤裕, 髙須千絵, 山田眞一郎, 和田佑馬, 太田昇吾, 岩橋祥子, 島田光生 : 青色LED光のOpn3を介した大腸癌抑制効果 (第2報), 第119回日本外科学会定期学術集会, 2019年4月.
275.	良元俊昭, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 森根裕二, 島田光生 : 大腸癌に対する青色LED光の光受容体を介した抗腫瘍効果, 第52回制癌剤適応研究会, 2019年3月.
276.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 濵田康弘 : 腹腔鏡下胃切除術における多職種介入術前減量プログラムの有用性, 第91回日本胃癌学会総会, 2019年2月.
277.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto : The usefulness of our step-wise training system for robotic assisted gastrectomy., 第91回日本胃癌学会総会, Feb. 2019.
278.	西正暁, 島田光生, 吉川幸造, 柏原秀也, 東島潤, 宮谷知彦, 徳永卓哉, 髙須千絵, 良元俊昭, 和田佑馬 : 腹腔鏡下胃癌手術のトレーニングプログラムの構築, 第91回日本胃癌学会総会, 2019年2月.
279.	徳永卓哉, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : TaTMEにおける尿道損傷回避のための工夫 ∼術中尿道造影の有用性∼, 第33回四国内視鏡外科研究会, 2019年2月.
280.	吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : Step-wise trainingシステムによる安全なロボット支援下胃切除導入の取り組み, 第33回四国内視鏡外科研究会, 2019年2月.
281.	西正暁, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 : 安全なロボット支援下胃癌手術の再導入, 第2回徳島外科医会, 2019年2月.
282.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵 : 腹腔鏡下胃切除術における肥満症例に対する取り組み∼術前減量プログラムの効果∼, 第31回日本内視鏡外科学会総会, 2018年12月.
283.	髙須千絵, 島田光生, 岩田貴, 吉川幸造, 東島潤, 西正暁, 徳永卓哉, 柏原秀也 : 内視鏡外科技術向上を目指した総合的トレーニング法の効果, 第31回日本内視鏡外科学会総会, 2018年12月.
284.	東島潤, 髙須千絵, 柏原秀也, 西正暁, 徳永卓哉, 宮谷知彦, 吉川幸造, 島田光生 : 腹腔鏡下前方切除術における縫合不全回避のためのICG蛍光法とサーモグラフィーによる血流評価の有用性, 第31回日本内視鏡外科学会総会, 2018年12月.
285.	岩田貴, 島田光生, 東島潤, 徳永卓哉, 西正暁, 髙須千絵 : 腹腔鏡下の局所解剖理解のためのVR実習と質的評価としてのルーブリック評価の検討, 第31回日本内視鏡外科学会総会, 2018年12月.
286.	西正暁, 島田光生, 吉川幸造, 柏原秀也, 東島潤, 徳永卓哉, 髙須千絵, 宮谷知彦 : 腹腔鏡下胃癌手術のトレーニングプログラムの構築, 第31回日本内視鏡外科学会総会, 2018年12月.
287.	吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : 腹腔鏡手術におけるノンテクニカルスキル評価法の開発, 第31回日本内視鏡外科学会総会, 2018年12月.
288.	徳永卓哉, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : TaTMEにおける尿道損傷回避のための術中尿道造影の有用性, 第31回日本内視鏡外科学会総会, 2018年12月.
289.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵 : ガーゼ剥離と膨潤TAPPを用いた腹腔鏡手術教育システムの有効性, 第80回日本臨床外科学会総会, 2018年11月.
290.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 宮谷知彦 : 腹腔鏡下胃癌手術のトレーニングプログラムの構築-Road to white surgery-, 第80回日本臨床外科学会総会, 2018年11月.
291.	吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : 胃癌に対するConversion surgeryの有用性, 第80回日本臨床外科学会総会, 2018年11月.
292.	岩田貴, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : 安全な中心静脈カテーテル(CVC)留置を目指したトレーニングシステムの構築・取組み・評価について, 第80回日本臨床外科学会総会, 2018年11月.
293.	東島潤, 良元俊昭, 髙須千絵, 柏原秀也, 西正暁, 徳永卓哉, 宮谷知彦, 吉川幸造, 島田光生 : Crohn's disease の外科治療成績について -Kono-S吻合の有用性-, 第110回日本消化器病学会四国支部例会, 2018年11月.
294.	東島潤, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : 大腸癌におけるmicroRNA-449a発現の意義, 第29回日本消化器癌発生学会総会, 2018年11月.
295.	柏原秀也, 良元俊昭, 髙須千絵, 西正暁, 徳永卓哉, 宮谷知彦, 東島潤, 吉川幸造, 森根裕二, 島田光生 : 大腸癌に対する青色LED光の効果と光受容体の関与についての研究, 第29回日本消化器癌発生学会総会, 2018年11月.
296.	岩橋祥子, 柏原秀也, 髙須千絵, 西正暁, 徳永卓哉, 宮谷知彦, 東島潤, 吉川幸造, 常山幸一, 島田光生 : Osteoclast-like giant cellを伴うhamartomatous inverted polypから発生したリンパ球浸潤胃癌の一例, 第29回日本消化器癌発生学会総会, 2018年11月.
297.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 石川大地 : CKLF like MARVEL transmembrane domain containing 6(CMTM6)を介した胃癌再発機構, JDDW2018, 2018年11月.
298.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 : 腹腔鏡下胃切除術における術前減量プログラムの効果, JDDW2018, 2018年11月.
299.	徳永卓哉, 島田光生, 東島潤, 吉川幸造, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 宮谷知彦 : 直腸縫合不全回避のためのICG蛍光法・サーモグラフィーを用いた血流評価の有用性, JDDW2018, 2018年11月.
300.	吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : StageIV胃癌に対するConversion surgeryにおける問題点と治療戦略, 第56回日本癌治療学会学術集会, 2018年10月.
301.	西正暁, 島田光生, 髙須千絵, 柏原秀也, 吉川幸造, 東島潤, 石川大地, 徳永卓哉, 和田佑馬, 宮谷知彦 : 胃癌におけるCMTM6発現の意義, 第56回日本癌治療学会学術集会, 2018年10月.
302.	徳永卓哉, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 : 腹腔鏡下前方切除術におけるICG蛍光法・サーモグラフィーによる血流評価の有用性, 第56回日本癌治療学会学術集会, 2018年10月.
303.	吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : Metabolic surgeryのNASH改善メカニズムに関する研究, 第27回消化器疾患病態治療研究会, 2018年9月.
304.	太田昇吾, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : NLRを用いた胃癌における再建術式別栄養・免疫機能評価, 第73回日本消化器外科学会総会, 2018年7月.
305.	石川大地, 髙須千絵, 柏原秀也, 西正暁, 徳永卓哉, 東島潤, 吉川幸造, 島田光生 : 再発及び前立腺摘出術後の鼠径ヘルニア症例に対するTAPP法の有用性, 第73回日本消化器外科学会総会, 2018年7月.
306.	髙須千絵, 岩田貴, 吉川幸造, 東島潤, 西正暁, 徳永卓哉, 柏原秀也, 石川大地, 島田光生 : 大健中湯は小腸パイエル版のPD-1発現を介してバクテリアルトランスロケーション発症を予防する可能性がある, 第73回日本消化器外科学会総会, 2018年7月.
307.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 : Metabolic surgeryのNASH改善メカニズムに関する研究, 第73回日本消化器外科学会総会, 2018年7月.
308.	西正暁, 島田光生, 髙須千絵, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 石川大地, 和田佑馬 : CMTM6による胃癌再発機構の解明, 第73回日本消化器外科学会総会, 2018年7月.
309.	徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 和田佑馬, 太田昇吾 : TaTMEにおける尿道損傷回避のための工夫, 第73回日本消化器外科学会総会, 2018年7月.
310.	東島潤, 島田光生, 石川大地, 髙須千絵, 柏原秀也, 西正暁, 徳永卓哉, 吉川幸造, 柏原秀也 : 局所進行下部直腸癌に対する術前化学放射線療法を用いた新たな治療戦略 ~Watch and wait導入へ向けて~, 第73回日本消化器外科学会総会, 2018年7月.
311.	吉川幸造, 島田光生, 沖津宏, 江藤祥平, 富林敦司, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : StageIV胃癌に対するConversion surgeryにおける問題点と治療戦略, 第73回日本消化器外科学会総会, 2018年7月.
312.	岩田貴, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : ルーブリック評価を用いた腹腔鏡トレーニングの質的評価と局所解剖理解のためのVR実習の検討, 第73回日本消化器外科学会総会, 2018年7月.
313.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵 : 胃癌におけるCMTM6発現の意義, 第25回外科侵襲とサイトカイン研究会, 2018年7月.
314.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 : 肥満患者に対する腹腔鏡下胃切除術における術前減量プログラムの効果, 第43回日本外科系連合学会学術集会, 2018年6月.
315.	徳永卓哉, 島田光生, 東島潤, 吉川幸造, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : TaTMEにおける尿道損傷回避のための工夫, 第43回日本外科系連合学会学術集会, 2018年6月.
316.	Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Hiroki Teraoku, Jun Higashijima, Chie Takasu and Mitsuo Shimada : Treatment guidance in resectable colorectal liver metastasis., 第30回日本肝胆膵外科学会学術集会, Jun. 2018.
317.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 : 大腸癌におけるmicroRNA-449a発現の意義, 第27回日本癌病態治療研究会, 2018年5月.
318.	東島潤, 島田光生, 森根裕二, 居村暁, 池本哲也, 吉川幸造, 森大樹, 徳永卓哉, 西正暁, 岩橋衆一, 齋藤裕, 柏原秀也, 髙須千絵, 矢田圭吾 : Academic surgeon 育成のための新たな研修への取り組み―大学病院と市中病院の新たな連携―, 第36回臨床研修研究会, 2018年4月.
319.	池本哲也, 島田光生, 髙須千絵, 和田佑馬 : IPMN悪性度診断に関する免疫学的パラメーターとIL-10発現に関する研究, 第104回日本消化器病学会総会, 2018年4月.
320.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地, 和田佑馬 : 肥満手術のインスリン抵抗性・NASH改善効果におけるマイクロバイオームの重要性, 第104回日本消化器病学会総会, 2018年4月.
321.	石川大地, 髙須千絵, 柏原秀也, 徳永卓哉, 東島潤, 吉川幸造, 髙須千絵, 島田光生 : 胃癌組織中に発現するmicroRNA-449aの意義解明についての研究, 第118回日本外科学会定期学術集会, 2018年4月.
322.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 : 肥満患者に対する腹腔鏡下胃・大腸切除術における術前減量プログラムの効果, 第118回日本外科学会定期学術集会, 2018年4月.
323.	吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : 腹腔鏡下胃全摘出術の食道空腸吻合法におけるOrVil法の有用性, 第118回日本外科学会定期学術集会, 2018年4月.
324.	岩田貴, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 赤池雅史 : 腹腔鏡トレーニングの質的評価としてのルーブリック評価の有用性の検討, 第118回日本外科学会定期学術集会, 2018年4月.
325.	髙須千絵, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 石川大地 : 大腸癌におけるPD-1/PDL-1発現の意義, 第118回日本外科学会定期学術集会, 2018年4月.
326.	岩橋祥子, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 石川大地, 三木浩和, 大浦雅博 : MDS・発作性夜間血色素尿症を合併する胃癌に対する手術が安全に施行可能であった1例, 第118回日本外科学会定期学術集会, 2018年4月.
327.	太田昇吾, 島田光生, 西正暁, 徳永卓哉, 東島潤, 石川大地, 吉川幸造, 髙須千絵, 柏原秀也, 森根裕二 : ICG蛍光システムを用いたTaTMEにおける尿道損傷回避に向けた取り組み, 第118回日本外科学会定期学術集会, 2018年4月.
328.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 髙須千絵, 柏原秀也, 石川大地, 和田佑馬 : 腫瘍免疫からみた大腸癌再発機構の解明, 第118回日本外科学会定期学術集会, 2018年4月.
329.	徳永卓哉, 島田光生, 東島潤, 吉川幸造, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 和田佑馬, 太田昇吾 : 腹腔鏡下前方切除術におけるICG蛍光法・サーモグラフィーによる血流評価の有用性, 第118回日本外科学会定期学術集会, 2018年4月.
330.	東島潤, 島田光生, 太田昇吾, 石川大地, 柏原秀也, 髙須千絵, 西正暁, 徳永卓哉, 吉川幸造 : 局所進行直腸癌に対する分子標的薬を加えた術前化学放射線療法の効果と感受性予測:基礎的検討と臨床成績, 第118回日本外科学会定期学術集会, 2018年4月.
331.	石川大地, 髙須千絵, 柏原秀也, 徳永卓哉, 西正暁, 東島潤, 吉川幸造, 島田光生 : 大腸癌の発癌・癌進展におけるmicroRNA-449aの役割解明, 第51回制癌剤適応研究会, 2018年3月.
332.	吉川幸造, 島田光生, 東島潤, 沖津宏, 江藤祥平, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : StageIV胃癌に対するConversion surgeryにおける問題点と治療戦略, 第51回制癌剤適応研究会, 2018年3月.
333.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 : 肥満患者に対する腹腔鏡下胃切除術における術前減量プログラム, 第90回日本胃癌学会総会, 2018年3月.
334.	西正暁, 島田光生, 吉川幸造, 柏原秀也, 東島潤, 徳永卓哉, 髙須千絵, 石川大地 : LECS for GIST -single center experience-, 第90回日本胃癌学会総会, 2018年3月.
335.	吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : The usefulness of the OrVil method and liver mobilization for optimal surgical field in LATG., 第90回日本胃癌学会総会, 2018年3月.
336.	徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : 鼠径ヘルニア再発症例に対するTAPP法の有用性, 第32回四国内視鏡研究会, 2018年2月.
337.	東島潤, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 和田佑馬, 太田昇吾 : 当科におけるTaTMEの導入について, 第32回四国内視鏡研究会, 2018年2月.
338.	吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : 肥満に対する腹腔鏡下Sleeve状胃切除の経験, 第32回四国内視鏡研究会, 2018年2月.
339.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 : ガーゼ剥離を用いた膨潤TAPP―再発症例より学至適剥離・メッシュ展開―, 第30回日本内視鏡外科学会総会, 2017年12月.
340.	徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : 腹腔鏡下腹壁瘢痕ヘルニア根治術に対するHybrid法の有用性, 第30回日本内視鏡外科学会総会, 2017年12月.
341.	東島潤, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 : 腹腔鏡下大腸手術における縫合不全回避のための血流評価の重要性, 第30回日本内視鏡外科学会総会, 2017年12月.
342.	徳永卓哉, 髙須千絵, 石川大地, 柏原秀也, 西正暁, 東島潤, 吉川幸造, 島田光生 : Hybrid法を用いた腹腔鏡下腹壁瘢痕ヘルニア根治術の安全性と有用性, 第79回日本臨床外科学会総会, 2017年11月.
343.	石川大地, 柏原秀也, 髙須千絵, 西正暁, 東島潤, 吉川幸造, 島田光生 : 鼠径ヘルニア再発症例に対するTAPP法の有用性, 第79回日本臨床外科学会総会, 2017年11月.
344.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 : ガーゼ剥離を用いた膨潤TAPP, 第79回日本臨床外科学会総会, 2017年11月.
345.	岩田貴, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : 腹腔鏡実習におけるルーブリック評価を用いた質的評価の検討, 第79回日本臨床外科学会総会, 2017年11月.
346.	森根裕二, 島田光生, 居村暁, 池本哲也, 岩橋衆一, 齋藤裕, 寺奥大貴, 髙須千絵, 東島潤 : 大腸癌切除不能両葉多発肝転移に対するFOLFOXIRI療法の有用性, 第79回日本臨床外科学会総会, 2017年11月.
347.	東島潤, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : 下部直腸癌に対するCRT効果予測因子としてのmiR223の意義, 第28回日本消化器癌発生学会総会, 2017年11月.
348.	西正暁, 島田光生, 石川大地, 髙須千絵, 徳永卓哉, 柏原秀也, 東島潤, 吉川幸造 : IDOによる免疫能と胃癌転移機構の解明, 第28回日本消化器癌発生学会総会, 2017年11月.
349.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 石川大地, 徳永卓哉 : 胃GISTに対する腹腔鏡・内視鏡合同手術(LECS)の検討, 第108回日本消化器病学会四国支部例会, 2017年11月.
350.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 石川大地 : The impact of Indoleaine 2,3-dioxygenase (IDO) expression in stagelll gastric cancer, 第55回日本癌治療学会学術集会, 2017年10月.
351.	和田佑馬, 森根裕二, 吉川幸造, 東島潤, 西正暁, 岩橋衆一, 柏原秀也, 髙須千絵, 齋藤裕, 石川大地, 寺奥大貴, 池本哲也, 居村暁, 島田光生 : 青色LED光は光受容体(opsin3)を介し癌細胞増殖を抑制する, 第55回日本癌治療学会学術集会, 2017年10月.
352.	石川大地, 良元俊昭, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵 : 青色LED光は光受容体(opsin)を介し癌細胞増殖を抑制する, 第76回日本癌学会学術総会, 2017年9月.
353.	徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : 地方におけるロボット手術の現状について, 第92回中国四国外科学会総会, 2017年9月.
354.	岩橋祥子, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 石川大地, 髙田厚史, 良元俊昭, 太田昇吾 : 術前診断が困難であった胃粘膜下異所性胃腺の1例, 第255回徳島医学会学術集会, 2017年8月.
355.	髙須千絵, 森根裕二, 居村暁, 池本哲也, 岩橋衆一, 齋藤裕, 石川大地, 吉川雅登, 市井啓仁, 島田光生 : 転写因子制御による肝虚血再灌流障害の新たな治療法の開発, 第255回徳島医学会学術集会, 2017年8月.
356.	岩田貴, 島田光生, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 長宗雅美, 赤池雅史 : 腹腔鏡下ペグタッチトレーニングの自学実習を目指したシミュレータの開発, 第49回日本医学教育学会大会, 2017年8月.
357.	石川大地, 良元俊昭, 髙須千絵, 柏原秀也, 東島潤, 吉川幸造, 島田光生 : 大腸癌の発癌・癌進展におけるmicroRNA-449aの役割解明, 第72回日本消化器外科学会総会, 2017年7月.
358.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵 : 肥満手術は町内最近叢変化を介して腸管炎症を抑制しインスリン抵抗性やNASH改善に寄与する, 第72回日本消化器外科学会総会, 2017年7月.
359.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 石川大地, 良元俊昭, 髙田厚史 : 下部直腸癌のCRT後NLRは予後不良因子になる, 第72回日本消化器外科学会総会, 2017年7月.
360.	東島潤, 石川大地, 柏原秀也, 髙須千絵, 西正暁, 吉川幸造, 島田光生 : 局所進行下部直腸癌に対する術前化学放射線療法の長期成績と新たな治療戦略, 第72回日本消化器外科学会総会, 2017年7月.
361.	東島潤, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : 下部直腸癌に対するCRT効果予測因子としてのmiR223の意義, 第87回大腸癌研究会, 2017年7月.
362.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵 : 腹腔鏡下胃切除術における肥満の影響と治療成績改善への取り組み, 日本外科代謝栄養学会第54回学術集会, 2017年7月.
363.	石川大地, 良元俊昭, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵 : 青色LED光の光受容体(opsin)を介した癌細胞増殖抑制効果の検討, 第42回日本外科系連合学会学術集会, 2017年6月.
364.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 : 外科診療における外来インフォームドコンセント導入の試み, 第42回日本外科系連合学会学術集会, 2017年6月.
365.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 石川大地 : 腹腔鏡下胃癌手術における吻合法の工夫, 第42回日本外科系連合学会学術集会, 2017年6月.
366.	髙須千絵, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 島田光生 : 女性外科医が働き続けるために, 第42回日本外科系連合学会学術集会, 2017年6月.
367.	東島潤, 島田光生, 吉川幸造, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : ICG蛍光システムを用いた腹腔鏡下前方切除術における縫合不全回避のための新たな戦略, 第42回日本外科系連合学会学術集会, 2017年6月.
368.	石川大地, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵 : 大腸癌の発癌・腫瘍進展におけるmicroRNA-449aの意義, 第107回日本消化器病学会四国支部例会, 2017年6月.
369.	石川大地, 東島潤, 島田光生, 吉川幸造, 西正暁, 柏原秀也, 髙須千絵 : 局所進行下部直腸癌に対するSOX+Bevレジメンによる術前化学放射線療法と効果予測因子としてのmiR-223の役割, 第26回日本癌病態治療研究会, 2017年6月.
370.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 西正暁, 徳永卓哉, 髙須千絵, 石川大地 : ガーゼ剥離を用いた膨潤TAPPの有用性, 第71回手術手技研究会, 2017年5月.
371.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 髙須千絵, 柏原秀也, 石川大地 : 腹腔鏡下胃癌手術における吻合術・視野展開の工夫, 第71回手術手技研究会, 2017年5月.
372.	森大樹, 石橋広樹, 矢田圭吾, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 島田光生 : 慢性炎症下の小児先天性胆道拡張症の胆道上皮における発癌関連遺伝子発現の検討, 第117回日本外科学会定期学術集会, 2017年4月.
373.	吉川幸造, 島田光生, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 吉川雅登, 良元俊昭 : 胃切除術における肥満の影響と治療成績改善への取り組み, 第117回日本外科学会定期学術集会, 2017年4月.
374.	東島潤, 島田光生, 吉川幸造, 西正暁, 柏原秀也, 髙須千絵, 石川大地 : 局所進行下部直腸癌に対するSOX+Bev regimenによる多剤併用術前化学放射線療法, 第117回日本外科学会定期学術集会, 2017年4月.
375.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 西正暁, 髙須千絵 : Metabolic surgery におけるmicrobiotaの変化は耐糖能異常・NAFLD/NASH改善に関与する, 第117回日本外科学会定期学術集会, 2017年4月.
376.	西正暁, 島田光生, 髙須千絵, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也 : IDOによる免疫能と胃癌転移機構, 第117回日本外科学会定期学術集会, 2017年4月.
377.	岩田貴, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 赤池雅史 : 腹腔鏡下eye hand coordinationトレーニングの自学実習を目指したシミュレータの開発, 第117回日本外科学会定期学術集会, 2017年4月.
378.	太田昇吾, 森根裕二, 吉川雅登, 居村暁, 池本哲也, 岩橋衆一, 齋藤裕, 石川大地, 髙田厚史, 良元俊昭, 髙須千絵, 東島潤, 島田光生 : 膵癌術後残膵再発に対する再切除導入効果の検証, 第117回日本外科学会定期学術集会, 2017年4月.
379.	良元俊昭, 吉川幸造, 森根裕二, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 岩橋衆一, 齋藤裕, 石川大地, 吉川雅登, 髙田厚史, 池本哲也, 居村暁, 島田光生 : 青色LED光は光受容体(opsin)を介し癌細胞増殖を抑制する, 第117回日本外科学会定期学術集会, 2017年4月.
380.	吉川雅登, Rui Feng, 森根裕二, 居村暁, 池本哲也, 岩橋衆一, 齋藤裕, 石川大地, 髙田厚史, 良元俊昭, 髙須千絵, 東島潤, 島田光生 : 肝細胞に対するROS/ ERK pathwayを介した赤色LED光の細胞増殖促進効果, 第117回日本外科学会定期学術集会, 2017年4月.
381.	石川大地, 良元俊昭, 髙田厚史, 吉川雅登, 髙須千絵, 齋藤裕, 岩橋衆一, 池本哲也, 居村暁, 森根裕二, 島田光生 : 大腸癌の発癌・腫瘍進展におけるmicroRNA-449aの意義, 第117回日本外科学会定期学術集会, 2017年4月.
382.	川下陽一郎, 森根裕二, 居村暁, 池本哲也, 岩橋衆一, 齋藤裕, 髙須千絵, 石川大地, 吉川雅登, 髙田厚史, 良元俊昭, 寺奥大貴, 島田光生 : 肝内胆管癌におけるHSF1発現の意義, 第117回日本外科学会定期学術集会, 2017年4月.
383.	池本哲也, 島田光生, 石川大地, 森根裕二, 居村暁, 東島潤, 岩橋衆一, 齋藤裕, 髙須千絵, 吉川雅登, 良元俊昭 : Tr1細胞とFoxp3調節性T細胞による腫瘍免疫状態を反映する免疫学的バイオマーカー探索, 第117回日本外科学会定期学術集会, 2017年4月.
384.	居村暁, 髙田厚史, 良元俊昭, 吉川雅登, 寺奥大貴, 石川大地, 齋藤裕, 髙須千絵, 岩橋衆一, 東島潤, 池本哲也, 森根裕二, 島田光生 : 肝切除シミュレーション・ナビゲーションを駆使した若手教育法の確立, 第117回日本外科学会定期学術集会, 2017年4月.
385.	森根裕二, 居村暁, 池本哲也, 岩橋衆一, 齋藤裕, 石川大地, 吉川雅登, 東島潤, 髙須千絵 : 大腸癌肝転移における治療指針 - 原発・転移巣の腫瘍悪性度は相関しない?, 第117回日本外科学会定期学術集会, 2017年4月.
386.	西正暁, 島田光生, 吉川幸造, 柏原秀也, 東島潤, 徳永卓哉, 髙須千絵, 石川大地 : 超高齢者に対する腹腔鏡下胃切除は安全に施行可能か?, 第103回日本消化器病学会総会, 2017年4月.
387.	石川大地, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵 : 腹腔鏡下前方切除術におけるICG蛍光システムを利用した予防的回腸ストーマ造設の適応, 第31回中国四国ストーマリハビリテーション研究会, 2017年3月.
388.	東島潤, 石川大地, 髙須千絵, 柏原秀也, 西正暁, 吉川幸造, 島田光生 : 肛門温存を可能とする早期下部直腸癌に対する術前化学放射線療法併用局所切除術の成績について, 第31回中国四国ストーマリハビリテーション研究会, 2017年3月.
389.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 西正暁, 髙須千絵 : 局所進行下部直腸癌に対するSOX+Bev regimenによる多剤併用術前化学放射療法, 第50回制癌剤適応研究会, 2017年3月.
390.	西正暁, 島田光生, 吉川幸造, 東島潤, 柏原秀也, 徳永卓哉, 髙須千絵, 石川大地, 髙田厚史, 良元俊昭 : Indoleamine 2,3-dioxygenase(IDO)による胃癌再発機構, 第50回制癌剤適応研究会, 2017年3月.
391.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 西正暁, 髙須千絵 : 耐糖能異常・NAFLD/NASHに対するRoux en Y再建の効果, 第89回日本胃癌学会総会, 2017年3月.
392.	吉川幸造, 島田光生, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 吉川雅登 : 肥満の胃切除術への影響と肥満患者における治療成績改善への取り組み, 第89回日本胃癌学会総会, 2017年3月.
393.	西正暁, 島田光生, 吉川幸造, 髙須千絵, 東島潤, 徳永卓哉, 柏原秀也, 石川大地 : IDOによる胃癌再発機構の解明, 第89回日本胃癌学会総会, 2017年3月.
394.	西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 髙須千絵, 柏原秀也, 石川大地, 髙田厚史, 良元俊昭 : 術前診断が困難であった胃粘膜下異所性胃腺の1例, 第66回日本消化器画像診断研究会, 2017年2月.
395.	西正暁, 東島潤, 石川大地, 柏原秀也, 髙須千絵, 徳永卓哉, 吉川幸造 : 下部直腸癌に対するCRT効果予測因子としてのmiR-223の意義, 第13回日本消化管学会総会学術集会, 2017年2月.
396.	石川大地, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵 : 腹腔鏡下前方切除術における縫合不全回避のためのICG蛍光システムの有用性, 第25回徳島外科術後管理研究会, 2017年2月.
397.	柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵 : 結腸切除術におけるDVTリスク評価とVTE予防, 第25回徳島外科術後管理研究会, 2017年2月.
398.	吉川幸造, 島田光生, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 吉川雅登 : 胃切除術における肥満の影響と治療成績改善への取り組み, 第25回徳島外科術後管理研究会, 2017年2月.
399.	吉川雅登, Rui Feng, 森根裕二, 居村暁, 池本哲也, 東島潤, 西正暁, 岩橋衆一, 齋藤裕, 髙須千絵, 石川大地, 髙田厚史, 良元俊昭, 島田光生 : 肝細胞に対するROS/ERK pathwayを介した赤色LED光の細胞増殖促進効果, 第46回日本創傷治癒学会, 2016年12月.
400.	吉川幸造, 島田光生, 東島潤, 西正暁, 柏原秀也, 髙須千絵 : 腹腔鏡下胃全摘におけるOrVil法の有用性, 第29回日本内視鏡外科学会総会, 2016年12月.
401.	良元俊昭, 吉川幸造, 松本規子, 馮睿, 髙田厚史, 髙須千絵, 柏原秀也, 西正暁, 東島潤, 島田光生 : LED光の癌細胞および正常細胞に対する効果, 第25回日本コンピュータ外科学会大会, 2016年11月.
402.	良元俊昭, 山田眞一郎, 島田光生, 森根裕二, 居村暁, 池本哲也, 齋藤裕, 吉川雅登, 髙田厚史, 髙須千絵 : EOB-MRIを用いた新たな肝切除限界予測の可能性, 第78回日本臨床外科学会総会, 2016年11月.
403.	森根裕二, 島田光生, 居村暁, 池本哲也, 岩橋衆一, 齋藤裕, 石川大地, 寺奥大貴, 吉川雅登, 髙須千絵, 荒川悠佑, 東島潤 : 大腸癌切除不能多発肝転移に対する治療戦略, 第78回日本臨床外科学会総会, 2016年11月.

講師 : 髙須千絵

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学術論文(紀要・その他):

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国際会議:

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講師 : 髙須 千絵

研究活動

専門分野

研究テーマ

著書・論文

学術論文(審査論文):

学術論文(紀要・その他):

総説・解説:

国際会議:

国内講演発表:

講師 : 髙須千絵