徳島大学 / 教育研究者総覧 --- 武川大輔

個人のホームページ

https://researchmap.jp/d-takegawa (researchmap)

専門分野

○	ライフサイエンス (Life sciences) [保存治療系歯学 (Conservative dentistry and endodontics)]

研究テーマ

著書・論文

学術論文(審査論文):

1.	Yoko Asahi, Katsuaki Naito, Hikaru Kanda, Kazuaki Niwano, Daisuke Takegawa, Hiromichi Yumoto, Yoichiro Noiri and Mikako Hayashi : Clinical investigation of the inhibitory effects of tooth-coating materials on initial active root caries: a pilot randomized controlled trial, Medicina, Vol.60, No.1, 150, 2024. (要約) : Caredyne ZIF-C is a novel, capsule-mixed zinc-containing prototype glass ionomer cement (GIC). Zinc ions are reported to inhibit root dentin demineralization, dentin collagen degradation, bacterial growth, acid production, and in vitro bacterial biofilm formation. However, the effectiveness of GICs against initial root caries lesions is unclear. Therefore, this study aimed to evaluate the efficacy of GICs, especially the new zinc-containing Caredyne ZIF-C GIC, as tooth-coating materials in patients with initial active root caries. : A total of 58 lesions in 47 older adults (age > 65 years) were randomly allocated to one of the following three groups: Caredyne ZIF-C, Fuji VII (a conventional GIC), and sodium fluoride (NaF). All the lesions were treated with the assigned materials without removing the infected dentin, and the rates of dental plaque attachment and coating material fall-out were evaluated after 3, 6, and 12 months. The failure rate was defined as the number of teeth that needed restoration due to caries progression. : The plaque attachment rates tended to be lower in the material-coated root surfaces than in the healthy exposed root surfaces after 3, 6, and 12 months, although the differences among the three groups were not significant. Moreover, the coating material fall-out rate tended to be lower in the Caredyne ZIF-C group than in the Fuji VII group. There was no significant difference in the failure rate among the three groups at the 12 months mark. : Though this pilot study offers a new direction for suppressing the progression of initial active root caries by controlling plaque attachment using GICs including Caredyne ZIF-C, clinical studies with a larger sample size are needed. (キーワード) Humans / Aged / Root Caries / Pilot Projects / Dental Caries / Health Status / Zinc (出版サイトへのリンク) ● Publication site (DOI): 10.3390/medicina60010150 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38256410 ● Search Scopus @ Elsevier (PMID): 38256410 ● Search Scopus @ Elsevier (DOI): 10.3390/medicina60010150 (DOI: 10.3390/medicina60010150, PubMed: 38256410)
2.	Hitomi Kuramoto, Tadashi Nakanishi, Daisuke Takegawa, MIEDA Katsuhiro and Keiichi Hosaka : Caffeic Acid Phenethyl Ester Induces Vascular Endothelial Growth Factor Production and Inhibits CXCL10 Production in Human Dental Pulp Cells, Current Issues in Molecular Biology, Vol.44, No.11, 5691-5699, 2022. (要約) The survival rate of root non-vital teeth is lower than that of vital teeth. Therefore, to preserve the dental pulp is very important. The vascular endothelial growth factor (VEGF) is the most potent angiogenic factor involved in the vitality of dental pulp including reparative dentin formation. Caffeic acid phenethyl ester (CAPE) is a physiologically active substance of propolis and has some bioactivities such as anti-inflammatory effects. However, there are no reports on the effects of CAPE on dental pulp inflammation. In this study, we investigated the effects of CAPE on VEGF and inflammatory cytokine production in human dental pulp cells (HDPCs) to apply CAPE to an ideal dental pulp protective agent. We found that CAPE induced VEGF production from HDPCs. Moreover, CAPE induced the phosphorylation of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases (ERK), and stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) in HDPCs. Furthermore, CAPE inhibited C-X-C motif chemokine ligand 10 (CXCL10) production in Pam3CSK4- and tumor necrosis factor-alpha (TNF-α)-stimulated HDPCs. In conclusion, these results suggest that CAPE might be useful as a novel biological material for vital pulp therapy by exerting the effects of VEGF production and anti-inflammatory activities. (キーワード) anti-inflammatory effect / caffeic acid phenethyl ester / dental pulp cells / 歯髄炎 (pulpitis) / 血管内皮増殖因子 (vascular endothelial growth factor) / vital pulp therapy (徳島大学機関リポジトリ) ● Metadata: 117775 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/cimb44110385 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36421669 ● Search Scopus @ Elsevier (PMID): 36421669 ● Search Scopus @ Elsevier (DOI): 10.3390/cimb44110385 (徳島大学機関リポジトリ: 117775, DOI: 10.3390/cimb44110385, PubMed: 36421669)
3.	Hitomi Kuramoto, Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa, Tadashi Nakanishi, Daisuke Takegawa, Ayako Washio, Chiaki Kitamura and Takashi Matsuo : Caffeic acid phenethyl ester (CAPE) induces VEGF expression and production in rat odontoblastic cells, BioMed Research International, Vol.Article ID 5390720, 2019. (要約) Caffeic acid phenethyl ester (CAPE), the main component of propolis, has various biological activities including anti-inflammatory effect and wound healing promotion. Odontoblasts located in the outermost layer of dental pulp play crucial roles such as production of growth factors and formation of hard tissue termed reparative dentin in host defense against dental caries. In this study, we investigated the effects of CAPE on the upregulation of vascular endothelial growth factor (VEGF) and calcification activities of odontoblasts, leading to development of novel therapy for dental pulp inflammation caused by dental caries. CAPE significantly induced mRNA expression and production of VEGF in rat clonal odontoblast-like KN-3 cells cultured in normal medium or osteogenic induction medium. CAPE treatment enhanced nuclear factor-kappa B (NF-B) transcription factor activation, and furthermore, the specific inhibitor of NF-B significantly reduced VEGF production. The expression of VEGF receptor- (VEGFR-) 2, not VEGFR-1, was up regulated in KN-3 cells treated with CAPE. In addition, VEGF significantly increased mineralization activity in KN-3 cells. These findings suggest that CAPE might be useful as a novel biological material for the dental pulp conservative therapy. (徳島大学機関リポジトリ) ● Metadata: 114566 (出版サイトへのリンク) ● Publication site (DOI): 10.1155/2019/5390720 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31930126 ● Summary page in Scopus @ Elsevier: 2-s2.0-85077441042 (徳島大学機関リポジトリ: 114566, DOI: 10.1155/2019/5390720, PubMed: 31930126, Elsevier: Scopus)
4.	平尾功治, 湯本浩通, 細川由樹, 蔵本瞳, 鷲尾絢子, 中西正, 武川大輔, 北村知昭, 松尾敬志 : ラット象牙芽細胞様細胞 (KN-3) におけるカテキンの抗炎症作用, 日本歯科保存学雑誌, Vol.60, No.5, 235-244, 2017年. (出版サイトへのリンク) ● Publication site (DOI): 10.11471/shikahozon.60.235 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680498132224 ● Search Scopus @ Elsevier (DOI): 10.11471/shikahozon.60.235 (DOI: 10.11471/shikahozon.60.235, CiNii: 1390282680498132224)
5.	Yuki Hosokawa, Kouji Hirao, Hiromichi Yumoto, Ayako Washio, Tadashi Nakanishi, Daisuke Takegawa, Chiaki Kitamura and Takashi Matsuo : Functional roles of NOD1 in odontoblasts on dental pulp innate immunity, BioMed Research International, Vol.2016, 9325436, 2016. (要約) Caries-related pathogens are first recognized by odontoblasts and induce inflammatory events that develop to pulpitis. Generally, initial sensing of microbial pathogens is mediated by pattern recognition receptors, such as Toll-like receptor and nucleotide-binding oligomerization domain (NOD); however, little is known about NODs in odontoblasts. In this study, the levels of NODs expressed in rat odontoblastic cell line, KN-3, were assessed by flow cytometry and the levels of chemokines in NOD-specific ligand-stimulated KN-3 cells were analyzed by real-time PCR and ELISA. The signal transduction pathway activated with NOD-specific ligand was assessed by blocking assay with specific inhibitors and reporter assay. In KN-3 cells, the expression level of NOD1 was stronger than that of NOD2 and the production of chemokines, such as CINC-1, CINC-2, CCL20, and MCP-1, was upregulated by stimulation with NOD1-specific ligand, but not with NOD2-specific ligand. CINC-2 and CCL20 production by stimulation with NOD1-specific ligand was reduced by p38 MAPK and AP-1 signaling inhibitors. Furthermore, the reporter assay demonstrated AP-1 activation in NOD1-specific ligand-stimulated KN-3 cells. These findings indicated that NOD1 expressed in odontoblasts functions to upregulate the chemokines expression via p38-AP-1 signaling pathway and suggested that NOD1 may play important roles in the initiation and progression of pulpitis. (キーワード) Animals / Cell Line / 細胞質分裂 (cytokinesis) / Dental Pulp / 自然免疫 (innate immunity) / Inflammation Mediators / Nod1 Signaling Adaptor Protein / Odontoblasts / Rats (徳島大学機関リポジトリ) ● Metadata: 112386 (出版サイトへのリンク) ● Publication site (DOI): 10.1155/2016/9325436 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27747243 ● Summary page in Scopus @ Elsevier: 2-s2.0-84991669747 (徳島大学機関リポジトリ: 112386, DOI: 10.1155/2016/9325436, PubMed: 27747243, Elsevier: Scopus)
6.	山村佳子, 滝沢宏光, 松本文博, 桃田幸弘, 青田桂子, 武川大輔, 近藤智香, 山ノ井朋子, 高野栄之, 可児耕一, 十川悠香, 河野文昭, 松尾敬志, 先山正二, 東雅之 : 胸腔鏡下肺葉切除術における周術期口腔機能管理の効果に関する検討―後ろ向き研究―, 日本口腔ケア学会雑誌, Vol.10, No.1, 106-110, 2016年. (キーワード) 胸腔鏡下肺葉切除術 / 周術期口腔機能管理 / 術後合併症 / thoracoscopic lung lobectomy / Perioperative oral management / postoperative complications (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1522262181026542720 (CiNii: 1522262181026542720)
7.	Tadashi Nakanishi, Kayo Mukai, Yoshitaka Hosokawa, Daisuke Takegawa and Takashi Matsuo : Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells, International Endodontic Journal, Vol.48, No.3, 277-282, 2015. (要約) To investigate the effect of catechins on vascular endothelial growth factor (VEGF) production and cyclooxygenase-2 (COX-2) expression in human dental pulp cells (HDPC) stimulated with bacteria-derived factors or pro-inflammatory cytokines. Morphologically fibroblastic cells established from explant cultures of healthy human dental pulp tissues were used as HDPC. HDPC pre-treated with catechins, epigallocatechin-3-gallate (EGCG) or epicatechin gallate (ECG), were exposed to lipopolysaccharide (LPS), peptidoglycan (PG), interlukin-1β (IL-1β) or tumour necrosis factor-α (TNF-α). VEGF production was examined by enzyme-linked immunosorbent assay, and COX-2 expression was assessed by immunoblot. EGCG and ECG significantly reduced LPS- or PG-mediated VEGF production in the HDPC in a dose-dependent manner. EGCG also prevented IL-1β-mediated VEGF production. Although TNF-α did not enhance VEGF production in the dental pulp cells, treatment of 20 μg mL(-1) of EGCG decreased the level of VEGF. In addition, the catechins attenuated COX-2 expression induced by LPS and IL-1β. The up-regulated VEGF and COX-2 expressions in the HDPC stimulated with these bacteria-derived factors or IL-1β were diminished by the treatment of EGCG and ECG. These findings suggest that the catechins may be beneficial as an anti-inflammatory tool of the treatment for pulpal inflammation. (キーワード) catechin / cyclooxygenase-2 / dental pulp / vascular endothelial growth factor (出版サイトへのリンク) ● Publication site (DOI): 10.1111/iej.12312 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24847951 ● Search Scopus @ Elsevier (PMID): 24847951 ● Search Scopus @ Elsevier (DOI): 10.1111/iej.12312 (DOI: 10.1111/iej.12312, PubMed: 24847951)
8.	青田桂子, 山村佳子, 山ノ井朋子, 武川大輔, 可児耕一, 高野栄之, 桃田幸弘, 松本文博, 菅原千恵子, 吉岡昌美, 河野文昭, 松尾敬志, 東雅之 : 徳島大学病院における周術期口腔機能管理の現状と課題, Journal of Oral Health and Biosciences, Vol.28, No.1, 29-36, 2015年. (要約) It has been shown that oral hygiene affects the onset of perioperative complications. The usefulness of perioperative oral function management aiming at the outbreak decrease in treatment complications and an early discharge was recognized. As a result, perioperative oral function management fee was founded at revision of medical service fees in Fiscal year 2012. In this clinical study, we evaluated the implementation of perioperative oral function management in Tokushima University Hospital. We examined 781 patients, including 563 patients for surgery and 218 patients for chemotherapy and radiotherapy. The mean age of patients was 58.8 ± 12.4 years old. The implementation rate of perioperative oral function management was 9.7% in the patients of surgery, and 17.4% in those of chemotherapy and radiotherapy. The highly required medical department was neurosurgery in the patients of surgery, and hematology in those of chemotherapy and radiotherapy. The mean number of tooth present was 21.3 ± 7.1 in the patients of surgery, and 19.8 ± 7.2 in those chemotherapy and radiotherapy. The rate of dental treatment was required in 40.5% of total patients who received surgery, and in 51.4% of patients who received chemotherapy and radiotherapy.The rate of patients who received denture treatment attained to 11.9% of the whole patients receiving surgery, and 13.3% of patients receiving chemotherapy and radiotherapy. It was revealed that there were many patients required potential demands in perioperative oral function management, and that there were many patients who need dental or denture treatment. We would like to develop perioperative oral function management by the interprofessional collaboration in health and social care.7月発行だが，6月号である． (キーワード) 徳島大学病院 / 周術期口腔機能管理 / チーム医療 (徳島大学機関リポジトリ) ● Metadata: 109866 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050020697877562496 (徳島大学機関リポジトリ: 109866, CiNii: 1050020697877562496)
9.	山村佳子, 青田桂子, 武川大輔, 十川悠香, 近藤智香, 山ノ井朋子, 高野栄之, 可児耕一, 松本文博, 桃田幸弘, 里見淳一郎, 河野文昭, 松尾敬志, 永廣信治, 東雅之 : 徳島大学病院脳卒中センターにおける口腔管理の意義について, Journal of Oral Health and Biosciences, Vol.9, No.1, 37-41, 2015年.
10.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Daisuke Takegawa, Yamanoi Tomoko, Kondo Chika, Shigemasa Tomioka and Masayuki Azuma : High-Wattage Pulsed Irradiation of Linearly Polarized Near-Infrared Light to Stellate Ganglion Area for Burning Mouth Syndrome, Case Reports in Dentistry, 2014. (要約) The purpose of this study was to apply high-wattage pulsed irradiation of linearly polarized near-infrared light to the stellate ganglion area for burning mouth syndrome (BMS) and to assess the efficacy of the stellate ganglion area irradiation (SGR) on BMS using differential time-/frequency-domain parameters (D parameters). Three patients with BMS received high-wattage pulsed SGR; the response to SGR was evaluated by visual analogue scale (VAS) representing the intensity of glossalgia and D parameters used in heart rate variability analysis. High-wattage pulsed SGR significantly decreased the mean value of VAS in all cases without any adverse event such as thermal injury. D parameters mostly correlated with clinical condition of BMS. High-wattage pulsed SGR was safe and effective for the treatment of BMS; D parameters are useful for assessing efficacy of SGR on BMS. (出版サイトへのリンク) ● Publication site (DOI): 10.1155/2014/171657 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25386367 ● Search Scopus @ Elsevier (PMID): 25386367 ● Search Scopus @ Elsevier (DOI): 10.1155/2014/171657 (DOI: 10.1155/2014/171657, PubMed: 25386367)
11.	Daisuke Takegawa, Tadashi Nakanishi, Kouji Hirao, Hiromichi Yumoto, Kanako Takahashi and Takashi Matsuo : Modulatory roles of interferon-γ through indoleamine 2, 3-dioxygenase induction in innate immune response of dental pulp cells., Journal of Endodontics, Vol.40, No.9, 1382-1387, 2014. (要約) Marked infiltration of inflammatory cells such as activated T cells producing interferon-γ (IFN-γ) is observed in severe pulpitis. However, the roles of IFN-γ in the innate immune response of dental pulp have not been reported. Indoleamine 2, 3-dioxygenase (IDO) is a regulator of immune responses, and the IDO expression is induced by IFN-γ in many cells whose expression in dental pulp is unknown. The purpose of this study was to determine the role of IFN-γ in the immune response through microbial pattern recognition receptors (PRRs) such as Toll-like receptors or nucleotide-binding oligomerization domain-like receptors on the production of proinflammatory cytokines such as CXCL10 and interleukin (IL)-6 and the expression of IDO in cultured human dental pulp cells (HDPCs). HDPCs were established from explant cultures of healthy pulp tissues. CXCL10 and IL-6 production was determined using enzyme-linked immunosorbent assay. Confirmation of IDO localization in dental pulp tissues was examined using immunohistochemistry. IDO expression in HDPCs was analyzed by immunoblot. IFN-γ significantly up-regulated CXCL10 and IL-6 production in the HDPCs stimulated with ligands for PRRs in a concentration-dependent manner. The expression of IDO was detected in inflamed pulp tissue. In addition, IFN-γ in combination with the PRR ligands enhanced IDO expression in HDPCs compared with IFN-γ alone. Moreover, CXCL10 production in IFN-γ-stimulated HDPCs was inhibited by an IDO inhibitor. This study showed the synergistic effects by IFN-γ on cytokine production and IDO expression in HDPCs, suggesting that IFN-γ may modulate the innate immune response of dental pulp. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.joen.2014.03.018 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25146019 ● Summary page in Scopus @ Elsevier: 2-s2.0-85027943562 (DOI: 10.1016/j.joen.2014.03.018, PubMed: 25146019, Elsevier: Scopus)
12.	桃田幸弘, 可児耕一, 高野栄之, 松本文博, 青田桂子, 武川大輔, 山ノ井朋子, 近藤智香, 東雅之 : 一次性舌痛症における手掌部発汗の発現-皮膚水分量測定の有用性について-, 日本歯科人間ドック学会誌, Vol.9, 18-23, 2014年.

総説・解説:

1.	武川大輔, 米倉和秀, 蔵本瞳, 伊田百美香, 細川由樹, 細川育子, 細川義隆, 菅俊行, 中西正, 保坂啓一 : 2級コンポジットレジン修復のキーポイント, Journal of Oral Health and Biosciences, Vol.36, No.1, 8-12, 2023年9月. (キーワード) 歯科医療 (dental care) (徳島大学機関リポジトリ) ● Metadata: 118637 (出版サイトへのリンク) ● Publication site (DOI): 10.20738/johb.36.1_8 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390016062665364224 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.36.1_8 (徳島大学機関リポジトリ: 118637, DOI: 10.20738/johb.36.1_8, CiNii: 1390016062665364224)
2.	武川大輔, 鴨居浩平, 保坂啓一 : デジタル技術を融合した次世代CR修復 : クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(11)バイレイヤー(2層)クリアインデックスを用いた下顎正中離開の修復, 日本歯科評論, Vol.82, No.11, 10-13, 2022年11月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520575444014801664 (CiNii: 1520575444014801664)
3.	Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Hitomi Kuramoto, Daisuke Takegawa, Tadashi Nakanishi and Takashi Matsuo : The Roles of Odontoblasts in Dental Pulp Innate Immunity, Japanese Dental Science Review, Vol.54, No.3, 105-117, Aug. 2018. (要約) Odontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external irritations. Therefore, odontoblasts possess a specialized innate immune system to fight oral pathogens invading into dentin. Generally, the rapid initial sensing of microbial pathogens, especially pathogen-associated molecular patterns (PAMPs) shared by microorganisms, are mediated by pattern recognition receptors (PRRs), such as Toll-like receptor and the nucleotide-binding oligomerization domain (NOD). The innate immune responses in odontoblasts initiated by sensing oral pathogens provide host protective events, such as inflammatory reactions, to produce a variety of pro-inflammatory mediators, including chemokines and cytokines. These attract various inflammatory cells and cause antibacterial reactions, such as the production of defensins, to kill microorganisms in the proximal region of the odontoblast layer. This review focuses on innate immunity, especially cellular and molecular mechanisms regarding the sensing of PAMPs from oral pathogens by PRRs, in odontoblasts and provides information for future studies for the development of novel therapeutic strategies, including diagnosis and treatment, to prevent exceeding dental pulp inflammation and preserve the dental pulp tissues. (徳島大学機関リポジトリ) ● Metadata: 112960 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jdsr.2018.03.001 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30128058 ● Summary page in Scopus @ Elsevier: 2-s2.0-85044379499 (徳島大学機関リポジトリ: 112960, DOI: 10.1016/j.jdsr.2018.03.001, PubMed: 30128058, Elsevier: Scopus)
4.	松尾敬志, 尾崎和美, 中西正, 湯本浩通, 高橋加奈子, 平尾功治, 武川大輔 : 歯髄疾患の病態と診断, 日本歯内療法学会雑誌, Vol.34, No.2, 67-76, 2013年5月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680166022016 (CiNii: 1390282680166022016)

国際会議:

1.	Yuki Hosokawa, Hiromichi Yumoto, Kouji Hirao, Hitomi Kuramoto, Tadashi Nakanishi, Daisuke Takegawa and Takashi Matsuo : Anti-inflammatory effects of polyphenols on rat odontoblastic cells, 95th General Session & Exhibition of the International Association for Dental Research (San Francisco), Mar. 2017.
2.	Daisuke Takegawa, Tadashi Nakanishi, Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa and Takashi Matsuo : Interferon-gamma modulates the innate immune response in odontoblast-like cells, 95th General session and exhibition of the IADR, Mar. 2017.
3.	Tadashi Nakanishi, Daisuke Takegawa, Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa and Takashi Matsuo : Effect of interleukin-17A on CCL20 production from odontoblast-like cells, 95th General session and exhibition of the IADR, Mar. 2017.
4.	Tadashi Nakanishi, Daisuke Takegawa, Hiromichi Yumoto, Kouji Hirao and Takashi Matsuo : Interleukin-17 Regulates Inflammatory Mediator Expression in IL-1beta-stimulated Dental Pulp Cells, 93th General Session & Exhibition of the International Association for Dental Research, Boston (USA), Mar. 2015.
5.	Tadashi Nakanishi, Daisuke Takegawa, Kouji Hirao, Hiromichi Yumoto, Kanako Takahashi and Takashi Matsuo : Prostaglandin F2a Regulates Cytokine Expression in Dental Pulp Cells, 91th General Session & Exhibition of the IADR, Seattle, USA, Mar. 2013.
6.	Daisuke Takegawa, Tadashi Nakanishi, Kouji Hirao, Hiromichi Yumoto, Kanako Takahashi and Takashi Matsuo : Interferon-g modulates the innate immune response of dental pulp cells, 91th General Session & Exhibition of the IADR, Seattle, USA, Mar. 2013.

国内講演発表:

1.	朝日陽子, 内藤克昭, 神田ひかる, 庭野和明, 武川大輔, 湯本浩通, 野杁由一郎, 林美加子 : 初期活動性根面う蝕患者におけるケアダインZIF-Cのバイオフィルム抑制効果に関する臨床評価, 日本歯科保存学会 2023年度秋季学術大会(第159回), 2023年11月.
2.	湯本華帆, 武川大輔, 鈴木善貴, 鴨居浩平, 大倉一夫, 小澤彩, 柴垣あかり, 富永賢, 保坂啓一, 松香芳三 : デジタル技術を用いて製作したミュージックスプリントの内面適合性に関する検討(第一報), 日本演奏芸術医学研究会, 2023年7月.
3.	湯本華帆, 鈴木善貴, 武川大輔, 大川敏永, 鴨居浩平, 小澤彩, 柴垣あかり, 新開瑞希, 谷脇竜弥, 富永賢, 保坂啓一, 松香芳三 : デジタル技術を利用したミュージックスプリントの内面適合性に関する評価法の検討, 四国歯学会雑誌, 2023年7月.
4.	三枝克啓, 中西正, 蔵本瞳, 細川義隆, 細川育子, 武川大輔, 保坂啓一 : Sudachitinがヒト歯髄細胞の炎症メディエーター発現に与える影響, 日本歯科保存学会 2023年度春季学術大会(第158回), 2023年6月.
5.	蔵本瞳, 中西正, 武川大輔, 三枝克啓, 保坂啓一 : Caffeic acid phenethyl ester (CAPE) がマウス骨芽細胞様細胞の組織修復関連因子発現に与える影響, 日本歯科保存学会 2023年度春季学術大会(第158回), 2023年6月.
6.	湯本華帆, 鈴木善貴, 鴨居浩平, 大倉一夫, 小澤彩, 新開瑞希, 谷脇竜弥, 大川敏永, 武川大輔, 大島正充, 松香芳三 : デジタルワークフローを用いたミュージックスプリント内面のデザインに関する予備検討, 日本補綴歯科学会雑誌, 2023年5月.
7.	三枝克啓, 中西正, 蔵本瞳, 武川大輔, 保坂啓一 : Interleukin-22 がヒト歯髄細胞の炎症性メディエーター発現に及ぼす影響, 第4回象牙質歯髄治療学会学術大会, 2023年5月.
8.	蔵本瞳, 中西正, 武川大輔, 細川由樹, 三枝克啓, 保坂啓一 : Caffeic acid phenethyl ester (CAPE)が歯髄細胞のVEGF産生に与える影響, 日本歯科保存学会2021年度秋季学術大会(第155回), 2021年10月.
9.	蔵本瞳, 平尾功治, 細川由樹, 武川大輔, 湯本浩通, 中西正 : ラット象牙芽細胞(KN-3)におけるVEGFの石灰化誘導作用, 日本歯科保存学会 2019年度秋季学術大会(第151回) (福岡), 2019年11月.
10.	武川大輔, 中西正, 平尾功治, 湯本浩通, 細川由樹, 蔵本瞳, 松尾敬志 : NODリガンド刺激したヒト象牙芽細胞様細胞におけるインターフェロンγの影響, 第150回日本歯科保存学会 2019年度春季学術大会, 2019年6月.
11.	蔵本瞳, 湯本浩通, 平尾功治, 細川由樹, 中西正, 武川大輔, 松尾敬志 : Caffeic Acid Phenetyl Ester (CAPE)の象牙芽細胞と骨芽細胞におけるVEGF産生誘導機序の解析, 第148回日本歯科保存学会春季学術大会, 2018年6月.
12.	蔵本瞳, 湯本浩通, 平尾功治, 細川由樹, 中西正, 武川大輔, 松尾敬志 : Caffeic Acid Phenethyl Ester (CAPE)のラット象牙芽細胞(KN-3)におけるVEGF産生に与える影響, 日本歯科保存学会2017年度春季学術大会(第146回), 2017年6月.
13.	中西正, 武川大輔, 平尾功治, 湯本浩通, 細川由樹, 松尾敬志 : Interleukin-17がラット象牙芽細胞様細胞(KN-3)のCCL20産生に及ぼす影響, 日本歯科保存学会 2015年度秋季学術大会(第143回), 2015年11月.
14.	細川由樹, 湯本浩通, 平尾功治, 中西正, 武川大輔, 松尾敬志 : 象牙芽細胞が有するMincleを介した視細胞認識機構とその歯髄炎症反応における役割, 日本歯科保存学会 2015年度秋季学術大会(第143回), 2015年11月.
15.	青田桂子, 山ノ井朋子, 近藤智香, 高野栄之, 武川大輔, 山村佳子, 可児耕一, 桃田幸弘, 松本文博, 東雅之 : 進行期肺がん患者の口腔管理∼ゾレドロン酸，デノスマブ投与前の歯科治療を考える∼, 第12回口腔ケア学会総会, 2015年6月.
16.	平尾功治, 湯本浩通, 細川由樹, 中西正, 武川大輔, 松尾敬志 : ラット象牙芽細胞(KN-3)の自然免疫反応におけるシグナル伝達経路の解析, 日本歯科保存学会2015年度春季学術大会(第142回), 2015年6月.
17.	細川由樹, 湯本浩通, 平尾功治, 中西正, 武川大輔, 松尾敬志 : ラット象牙芽細胞(KN-3)に対するカテキンとカフェイン酸の抗炎症作用, 日本歯科保存学会2015年度春季学術大会(第142回), 2015年6月.
18.	桃田幸弘, 可児耕一, 高野栄之, 松本文博, 青田桂子, 武川大輔, 山ノ井朋子, 近藤智香, 東雅之 : 新規口腔ケア製品「ペプチサルシリーズ」の使用感に関する調査, 第12回日本口腔ケア学会, 2015年6月.
19.	青田桂子, 山村佳子, 山ノ井朋子, 近藤智香, 武川大輔, 可児耕一, 高野栄之, 桃田幸弘, 松本文博, 東雅之 : Sjögren 症候群唾液腺における IP-10 の役割, 第51回日本口腔組織培養学会学術大会, 2014年11月.
20.	中西正, 武川大輔, 平尾功治, 湯本浩通, 松尾敬志 : Interleukin-17がヒト歯髄線維芽細胞の炎症メディエーター発現に及ぼす影響, 日本歯科保存学会2014年度秋季学術大会(第141回), 2014年10月.
21.	山村佳子, 滝沢宏光, 松本文博, 桃田幸弘, 青田桂子, 武川大輔, 可児耕一, 高野栄之, 山ノ井朋子, 近藤智香, 金川裕子, 高瀬奈緒, 十川悠香, 東雅之 : 肺癌患者における周術期口腔機能管理の有用性について-術後合併症の観点より-, 第62回NPO法人日本口腔科学会中国・四国地方部会, 2014年10月.
22.	可児耕一, 桃田幸弘, 高野栄之, 松本文博, 青田桂子, 山村佳子, 武川大輔, 山ノ井朋子, 近藤智香, 金川裕子, 東雅之 : 徳島大学病院口腔内科組織改編前後の患者動向について, 第24回日本口腔内科学会, 2014年9月.
23.	可児耕一, 桃田幸弘, 高野栄之, 松本文博, 青田桂子, 山村佳子, 武川大輔, 山ノ井朋子, 近藤智香, 金川裕子, 東雅之 : 徳島大学病院口腔内科発足前後の患者動向について, 第45回四国歯学会例会・第33回四国歯学会総会, 2014年6月.
24.	平尾功治, 湯本浩通, 中西正, 篠原千尋, 高橋加奈子, 武川大輔, 細川由樹, 松尾敬志 : ラット象牙芽細胞様細胞(KN3)における細菌関連病原因子刺激に対する自然免疫反応の解析, 日本歯科保存学会2014年度春季学術大会(第140回), 2014年6月.
25.	中西正, 武川大輔, 平尾功治, 湯本浩通, 高橋加奈子, 松尾敬志 : prostaglandin F2aは歯髄細胞における炎症性メディエーター発現を調節する, 第136回日本歯科保存学会春季学術大会, 2012年6月.

その他・研究会:

1.	里見淳一郎, 山村佳子, 青田桂子, 武川大輔, 松本文博, 十川悠香, 東雅之 : 徳島大学病院脳卒中センターにおける口腔管理の意義について, 第17回徳島脳卒中研究会, 2015年2月.
2.	可児耕一, 桃田幸弘, 高野栄之, 青田桂子, 松本文博, 山村佳子, 武川大輔, 山ノ井朋子, 近藤智香, 金川裕子, 東雅之 : がん治療における周術期口腔機能管理の現状と課題, 徳島大学病院Cancer Board, 2014年9月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

デジタル技術を活用したミュージックスプリントの革新：木管楽器奏者の口腔問題対策 (研究課題/領域番号: 24K03557 )
初期の歯髄炎における象牙芽細胞の石灰化と生体防御機構の解明 (研究課題/領域番号: 17K11709 )
歯髄炎の病態形成における象牙芽細胞の細菌由来因子に対する自然免疫機構の解明 (研究課題/領域番号: 15K20406 )
歯髄炎の病態形成における歯髄細胞の細菌由来因子に対する自然免疫機構の解明 (研究課題/領域番号: 25861802 )
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助教 : 武川大輔

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

助教 : 武川大輔