Tokushima University / Educator and Researcher Directory --- Okamura, Kazumi

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Academic Paper (Judged Full Paper):

1.	Kazumi Okamura, Lifang Wang, Satoshi Nagayama, Makiko Yamashita, Tomohiro Tate, Saki Matsumoto, Manabu Takamatsu, Shigehisa Kitano, Kazuma Kiyotani and Yusuke Nakamura : Characterization of double-negative T cells in colorectal cancers and their corresponding lymph nodes., Oncoimmunology, Vol.13, No.1, 2024. (Summary) TCRαβ+ CD4- CD8- double-negative T (DNT) cells are minor populations in peripheral blood, and their roles have mostly been discussed in inflammation and autoimmunity. However, the functions of DNT cells in tumor microenvironment remain to be elucidated. We investigated their characteristics, possible origins and functions in colorectal cancer tissues as well as their corresponding tumor-draining lymph nodes. We found a significant enrichment of DNT cells in tumor tissues compared with their corresponding lymph nodes, especially in tumors with lower T cell infiltration. T cell receptor (TCR) sequence analysis of CD4+ T, CD8+ T and DNT cells indicated that TCR sequences detected in DNT cells were found in CD8+ T cells, but rarely in CD4+ T cells, suggesting that a part of DNT cells was likely to be originated from CD8+ T cells. Through a single-cell transcriptomic analysis of DNT cells, we found that a DNT cell cluster, which showed similar phenotypes to central memory CD8+ T cells with low expression of effector and exhaustion markers, revealed some specific gene expression patterns, including higher GZMK expression. Moreover, in flow cytometry analysis, we found that DNT cells lost production of cytotoxic mediators. These findings imply that DNT cells might function as negative regulators of anti-tumor immune responses in tumor microenvironment. (Keyword) Humans / Colorectal Neoplasms / Lymph Nodes / Tumor Microenvironment / CD8-Positive T-Lymphocytes / Lymphocytes, Tumor-Infiltrating / Male / Female / CD4-Positive T-Lymphocytes / Aged / Receptors, Antigen, T-Cell / T-Lymphocyte Subsets / Middle Aged (Link to Publication Site) ● Publication site (DOI): 10.1080/2162402X.2024.2373530 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38979545 ● Search Scopus @ Elsevier (PMID): 38979545 ● Search Scopus @ Elsevier (DOI): 10.1080/2162402X.2024.2373530 (DOI: 10.1080/2162402X.2024.2373530, PubMed: 38979545)
2.	Kazumi Okamura, Satoshi Nagayama, Tomohiro Tate, Ting Hiu Chan, Kazuma Kiyotani and Yusuke Nakamura : Lymphocytes in tumor-draining lymph nodes co-cultured with autologous tumor cells for adoptive cell therapy., Journal of translational medicine, Vol.20, No.1, 2022. (Summary) Our results imply that tumor-reactive effector T cells were present even in pathologically non-metastatic lymph nodes and could be expanded in vitro in the presence of autologous tumor cells and possibly be applied for ACT. (Keyword) CD8-Positive T-Lymphocytes / Cell- and Tissue-Based Therapy / Coculture Techniques / Humans / Immunotherapy, Adoptive / Lymph Nodes / Lymphocytes / Lymphocytes, Tumor-Infiltrating / Neoplasms / Receptors, Antigen, T-Cell (Link to Publication Site) ● Publication site (DOI): 10.1186/s12967-022-03444-1 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35606862 ● Search Scopus @ Elsevier (PMID): 35606862 ● Search Scopus @ Elsevier (DOI): 10.1186/s12967-022-03444-1 (DOI: 10.1186/s12967-022-03444-1, PubMed: 35606862)
3.	森輝実, Tatsuro Miyamoto, Mariko Egawa, Yoshinori Mitamura, Yuko Ichihara, Kazumi Okamura and Hiroyoshi Watanabe : 両眼性の漿液性網膜剥離をきたした急性リンパ性白血病の1例, Japanese Journal of Clinical Ophthalmology, Vol.71, No.6, 905-912, 2017. (Link to Publication Site) ● Publication site (DOI): 10.11477/mf.1410212302 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390002209944414976 ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1410212302 (DOI: 10.11477/mf.1410212302, CiNii: 1390002209944414976)
4.	Kazumi Okamura, Akiko Kitamura, Yoshiteru Sasaki, Hyun Doo Chung, Shoji Kagami, Kazuhiro Iwai and Koji Yasutomo : Survival of mature T cells depends on signaling through HOIP., Scientific Reports, Vol.6, 36135, 2016. (Summary) T cell development in the thymus is controlled by a multistep process. The NF-B pathway regulates T cell development as well as T cell activation at multiple differentiation stages. The linear ubiquitin chain assembly complex (LUBAC) is composed of Sharpin, HOIL-1L and HOIP, and it is crucial for regulating the NF-B and cell death pathways. However, little is known about the roles of LUBAC in T-cell development and activation. Here, we show that in T-HOIP(linear) mice lacking the ubiquitin ligase activity of LUBAC, thymic CD4(+) or CD8(+) T cell numbers were markedly reduced with severe defects in NKT cell development. HOIP(linear) CD4(+) T cells failed to phosphorylate IB and JNK through T cell receptor-mediated stimulation. Mature CD4(+) and CD8(+) T cells in T-HOIP(linear) mice underwent apoptosis more rapidly than control T cells, and it was accompanied by lower CD127 expression on CD4(+)CD24(low) and CD8(+)CD24(low) T cells in the thymus. The enforced expression of CD127 in T-HOIP(linear) thymocytes rescued the development of mature CD8(+) T cells. Collectively, our results showed that LUBAC ligase activity is key for the survival of mature T cells, and suggest multiple roles of the NF-B and cell death pathways in activating or maintaining T cell-mediated adaptive immune responses. (Tokushima University Institutional Repository) ● Metadata: 112366 (Link to Publication Site) ● Publication site (DOI): 10.1038/srep36135 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27786304 ● Search Scopus @ Elsevier (PMID): 27786304 ● Search Scopus @ Elsevier (DOI): 10.1038/srep36135 (Tokushima University Institutional Repository: 112366, DOI: 10.1038/srep36135, PubMed: 27786304)
5.	Nami Inoue, Hiroyoshi Watanabe, Kazumi Okamura, Shuji Kondo and Shoji Kagami : Are the equations for the creatinine-based estimated glomerular filtration rate applicable to the evaluation of renal function in Japanese children and adult patients receiving chemotherapy?, Clinical and Experimental Nephrology, Vol.19, No.2, 298-308, 2015. (Summary) Equations for the creatinine-based estimated glomerular filtration rate (eGFR) were recently established for Japanese adults (>18 years old) and children (2-11 years old), respectively, but it is unclear whether eGFR can be as useful as 24-h creatinine clearance (CCr) for assessing renal function in patients receiving chemotherapy. This study examined the degree of concordance between eGFR and CCr and the risk factors leading to the overestimation of renal function by eGFR. A total of 53 data points of 19 children and 56 data points of 16 adults who received chemotherapy were analyzed retrospectively. Body mass index, serum creatinine concentration, 24-h urinary creatinine excretion (UCr), and nephrectomy were considered as risk factors for overestimation by eGFR. In the pediatric part of the study, 7 data points from 3 patients who underwent nephrectomy were included. The eGFR in patients with bilateral kidneys overestimated renal function to a greater degree than in patients with a unilateral kidney. In 45.7 % of pediatric patients with bilateral kidneys and in 19.6 % of adult patients, eGFR overestimated renal function. The risk factor for overestimation was lower UCr in pediatric patients with bilateral kidneys and adult patients. Concordance between eGFR and CCr in pediatric patients with a unilateral kidney should be assessed separately from that in patients with bilateral kidneys. In restricting calculation of eGFR to pediatric patients with bilateral kidneys and adult patients without little muscle mass, eGFR may be useful regardless of whether patients are receiving chemotherapy. (Keyword) Adult / Antineoplastic Agents / Area Under Curve / Body Mass Index / Child / Child, Preschool / Creatinine / Female / Glomerular Filtration Rate / Humans / Japan / Lactones / Male / Mathematical Concepts / Neoplasms / Nephrectomy / ROC Curve / Retrospective Studies / Risk Factors / Young Adult (Link to Publication Site) ● Publication site (DOI): 10.1007/s10157-014-0976-z (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24792810 ● Summary page in Scopus @ Elsevier: 2-s2.0-84939885484 (DOI: 10.1007/s10157-014-0976-z, PubMed: 24792810, Elsevier: Scopus)
6.	Tatsuo Mori, 関口隆憲 and Kazumi Okamura : A case of disseminated neonatal herpes simplex virus infection, Japanese Journal of Pediatrics, Vol.62, No.10, 2233-2238, 2009. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1523669554611294208 (CiNii: 1523669554611294208)

Academic Paper (Unrefereed Paper):

1.	N Nakamura, Hiroyoshi Watanabe, Kazumi Okamura and Shoji Kagami : Assessment of renal function in Japanese children with malignancies using serum cystatin C., The Journal of Medical Investigation : JMI, Vol.65, No.3,4, 231-235, 2018. (Summary) Several factors besides renal function influence serum cystatin C (CysC) levels. The present study evaluates the value of serum CysC and the equation for CysC based estimated glomerular filtration rate (CysC-eGFR) for Japanese children with malignancies. We collected information at 36 time points from 13 patients aged ≤ 17 years with malignancies. We assessed tumor activity, cell recovery phase after chemotherapy, neutropenia phase, inflammation response and medication with granulocyte-colony stimulating factor, steroid, and levothyroxine as risk factors associated with serum CysC levels. Although no 24-h creatinine clearance (CCr) data collected at 36 time points indicated renal dysfunction, serum CysC levels were above and below the reference values at four and five time points, respectively. The frequency of elevated serum CysC levels was higher in patients without therapy or with stable or progressive disease than among those with a complete or partial response (p = 0.0046). The correlation coefficient between CCr and CysC-eGFR was 0.355 (p = 0.054), but this improved to 0.663 (p = 0.0010) when restricted to patients with a complete or partial response. Levels of serum CysC might become elevated regardless of renal function, and CysC-eGFR might become unpredictable during the active phase of tumors. J. Med. Invest. 65:231-235, August, 2018. (Keyword) Adolescent / Antineoplastic Agents / Biomarkers / Child / Child, Preschool / Creatinine / Cystatin C / Female / Glomerular Filtration Rate / Humans / Infant / Kidney / Kidney Function Tests / Male / Neoplasms (Tokushima University Institutional Repository) ● Metadata: 112244 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.65.231 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30282866 ● Search Scopus @ Elsevier (PMID): 30282866 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.65.231 (Tokushima University Institutional Repository: 112244, DOI: 10.2152/jmi.65.231, PubMed: 30282866)
2.	Nami Inoue, Hiroyoshi Watanabe, Kazumi Okamura, Mika Sakaki, Teruyoshi Kageji, Shinji Nagahiro and Shoji Kagami : Atypical teratoid rhabdoid tumor in the cavernous sinus of a toddler presenting with oculomotor nerve palsy., Child's Nervous System, Vol.30, No.8, 1463-1466, 2014. (Summary) Atypical teratoid rhabdoid tumor (ATRT) is a rare, highly malignant, and aggressive tumor of infancy. Although the prognosis of ATRT has been extremely poor, recently, the first prospective study for ATRT demonstrated improvement of prognosis. On the other hands, oculomotor nerve palsy is rare in children and the most frequent etiology is congenital. To our knowledge, only a few ATRT cases presenting with oculomotor nerve palsy have been reported, but ATRT originating from the cavernous sinus (CS) has not yet been reported. An 18-month-old girl with right oculomotor nerve palsy was admitted, and a small mass in the right CS was detected with brain MRI. Although she received steroid pulse therapy and antimicrobial therapy, the mass continued to enlarge. One month after admission, the mass was partially resected and diagnosed as ATRT. Multimodal therapy including anthracycline-based chemotherapy, intrathecal therapy, and cranial irradiation was performed. Twenty-nine months after resection, she was alive without tumor relapse, but the oculomotor nerve palsy persisted. This is the first reported case of ATRT located in the CS presenting with oculomotor nerve palsy. This case was successfully treated with partial removal of the tumor, a new chemotherapy regimen for ATRT and cranial X-ray irradiation. (Keyword) Cavernous Sinus / Female / Humans / infant / magnetic resonance imaging / Neoplasms, Vascular Tissue / Oculomotor Nerve Diseases / Rhabdoid Tumor (Link to Publication Site) ● Publication site (DOI): 10.1007/s00381-014-2407-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24682530 ● Summary page in Scopus @ Elsevier: 2-s2.0-84906938246 (DOI: 10.1007/s00381-014-2407-6, PubMed: 24682530, Elsevier: Scopus)

Proceeding of International Conference:

1.	Teruyoshi Kageji, Yoshifumi Mizobuchi, Kohhei Nakajima, Hiroyoshi Watanabe, Kazumi Okamura, Shoji Kagami and Shinji Nagahiro : Intensive chemotherapy followed by reduced radiation dose for intracranial non-germinomatous germ cell tumors, 20th Annual Socientific Meeting and Education Day of the Society for Neuro-Oncology, Nov. 2015.
2.	Kazumi Okamura and Koji Yasutomo : CHD-mediated T cell regulation, Symposium of Genetic and epigenetic control of cell fate, Nov. 2012.

Proceeding of Domestic Conference:

1.	Hiroyoshi Watanabe, Kazumi Okamura, 戸梶成美, 村松秀城 and Shoji Kagami : PTPN11遺伝子変異を認めた3症例, 第70回中国四国小児科学会, Nov. 2018.
2.	Kazumi Okamura, Hiroyoshi Watanabe, 古本哲朗, 岡田朝美 and Shoji Kagami : 二次がんとして横紋筋肉腫を発症した2例, 第60回日本小児血液・がん学会, Nov. 2018.
3.	Hiroyoshi Watanabe, Kazumi Okamura, 大隅敬太, 市原裕子, 森本友樹, Koichi Tsuneyama and Shoji Kagami : 治療抵抗性の悪性骨軟部腫瘍に対するPazopanibの使用経験~免疫組織化学染色による検討~, 第60回日本小児血液・がん学会, Nov. 2018.
4.	武井美貴子, Hiroyoshi Watanabe, Kazumi Okamura, Mika Takahashi and Shoji Kagami : 顔面神経麻痺で発症し化学療法が奏効した側頭骨原発Infantile Myofibromaの乳児例, 第69回中国四国小児科学会, Nov. 2017.
5.	Hiroyoshi Watanabe, Kazumi Okamura, 大隅敬太, 市原裕子 and Shoji Kagami : 治療抵抗性悪性軟部腫瘍3例に対するPazopanibの使用経験, 第59回日本小児血液・がん学会, Nov. 2017.
6.	Kazumi Okamura, Hiroyoshi Watanabe, 大隅敬太 and Shoji Kagami : 同種造血幹細胞移植後にEBV再活性化による髄膜脳炎を呈したALLの1例, 第59回日本小児血液・がん学会, Nov. 2017.
7.	武井美貴子, Hiroyoshi Watanabe, Kazumi Okamura, Shoji Kagami and 小林正夫 : 高用量免疫グロブリンを併用した免疫寛容導入療法がインヒビターの早期根絶に有効であった先天性血友病Aの一例, 第147回日本小児科学会徳島地方会, Dec. 2016.
8.	Hiroyoshi Watanabe, Kazumi Okamura, Keisuke Fujioka and Shoji Kagami : 水痘帯状疱疹ウイルス再活性化によるHLHを合併したT-ALL ~サイトカイン測定による病態の検討~, 第58回日本小児血液・がん学会, Dec. 2016.
9.	Kazumi Okamura, Hiroyoshi Watanabe, 阿部容子, Shoji Kagami, Atsuro Saijo, Satoshi Sakaguchi and Yasuhiko Nishioka : アレクチニブが奏効したALK陽性肺腺癌の12歳男児例, 第58回日本小児血液・がん学会, Dec. 2016.
10.	森輝実, Tatsuro Miyamoto, Mariko Egawa, Yoshinori Mitamura, 市原裕子, Kazumi Okamura and Hiroyoshi Watanabe : 原田病に類似した両眼性漿液性網膜剥離を呈した急性リンパ性白血病の1例, 第70回日本臨床眼科学会, Nov. 2016.
11.	Kazumi Okamura, Hiroyoshi Watanabe, 市原裕子, Shoji Kagami and Nami Inoue : 腸腰筋膿瘍，深部静脈血栓症を合併した急性骨髄性白血病(AML M2)の女児例, 第119回日本小児科学会学術総会, May 2016.
12.	阿部容子, Kazumi Okamura, Hiroyoshi Watanabe, Shoji Kagami, 佐々木亜由美, Satoshi Sakaguchi and Yasuhiko Nishioka : アレクチニブが奏効したALK陽性肺腺癌の1男児例, 第145回日本小児科学会徳島地方会, Dec. 2015.
13.	栗原健士, Kazumi Okamura, 市原裕子, Hiroyoshi Watanabe and Shoji Kagami : 急性リンパ性白血病の再発時MRD検索は治療方針決定に有用か?, 第145回日本小児科学会徳島地方会, Dec. 2015.
14.	Hiroyoshi Watanabe, Kazumi Okamura, Nami Inoue and Shoji Kagami : 小児患者における同種造血幹細胞移植後の生着症候群と生着前症候群について, 第57回日本小児血液・がん学会, Nov. 2015.
15.	Nami Inoue, Hiroyoshi Watanabe, Kazumi Okamura and Shoji Kagami : 小児がん患者の腎機能評価における血清シスタチン C の有用性, 第57回日本小児血液・がん学会, Nov. 2015.
16.	Hiroyoshi Watanabe, Kazumi Okamura, Nami Inoue, Teruyoshi Kageji and Shoji Kagami : 頭蓋内悪性胚細胞腫瘍に対する化学療法の強化による放射線療法の減量の試み, 第67回中国四国小児科学会(, Nov. 2015.
17.	Kohhei Nakajima, Yoshifumi Mizobuchi, Teruyoshi Kageji, Kazumi Okamura, Hiroyoshi Watanabe and Shinji Nagahiro : 悪性胚細胞性腫瘍に対する化学療法を強化した集学的治療, 一般社団法人日本脳神経外科学会第74回学術総会, Oct. 2015.
18.	Kazumi Okamura, Hiroyoshi Watanabe, 本間友佳子, Nami Inoue, Shoji Kagami, Keigo Yada and Hiroki Ishibashi : 多剤併用化学療法後も全摘出困難であった神経芽細胞腫(中間リスク限局例), 第144回日本小児科学会徳島地方会, Jun. 2015.
19.	Miho Sakata, Yasunobu Hayabuchi, 近藤朝美, 永井隆, Kazumi Okamura, Mayumi Sugimoto, Hiromichi Ito, Maki Urushihara, Shuji Kondo, Hiroyoshi Watanabe, Shoji Kagami, Hajime Kinoshita, Takashi Kitaichi and Tetsuya Kitagawa : 急激な循環不全を呈し，慢性期に拡張型心筋症へ移行した急性壊死性好酸球性心筋炎の一例, 第29回日本小児循環器学会近畿中四国地方会, Mar. 2015.
20.	Miho Sakata, Yasunobu Hayabuchi, 近藤朝美, 永井隆, Kazumi Okamura, Mayumi Sugimoto, Hiromichi Ito, Maki Urushihara, Shuji Kondo, Hiroyoshi Watanabe, Shoji Kagami, Hajime Kinoshita, Takashi Kitaichi and Tetsuya Kitagawa : 急激な循環不全を呈し，慢性期に拡張型心筋症へ移行した急性壊死性好酸球性心筋炎の一例, 第29回日本小児循環器学会近畿中四国地方会, Mar. 2015.
21.	古本哲朗, Hiroyoshi Watanabe, Kazumi Okamura, Nami Inoue, Ken-ichi Suga and Shoji Kagami : HHV-6の関与が疑われる後天性赤芽球癆の一例, 第143回日本小児科学会徳島地方会, Dec. 2014.
22.	松崎苑美, Kazumi Okamura, Nami Inoue, Hiroyoshi Watanabe, 小野朱美, Yoshimi Bando and Shoji Kagami : 呼吸不全で発症し免疫不全が疑われた多臓器型ランゲルハンス細胞組織球症の乳児例, 第143回日本小児科学会徳島地方会, Dec. 2014.
23.	Hiroyoshi Watanabe, Nami Inoue, Kazumi Okamura, Teruyoshi Kageji and Shoji Kagami : 頭蓋内悪性胚細胞性腫瘍に対する化学療法の強化による放射線療法の減量の試み, 第56回日本小児血液・がん学会, Nov. 2014.
24.	Kazumi Okamura, Hiroyoshi Watanabe, 松崎苑美, 藤岡啓介, Nami Inoue and Shoji Kagami : VZV(水痘帯状疱疹ウイルス)再活性化によりPRES(Posterior Reversible Encephalopathy Syndrome)，ARDS(Acute Respiratory Distress Syndrome)，HLH(Hemophagocytic Lymphohistiocytosis)を合併したT-ALLの一例, 第56回日本小児血液・がん学会, Nov. 2014.
25.	古本哲朗, Hiroyoshi Watanabe, Kazumi Okamura, Nami Inoue, Ken-ichi Suga and Shoji Kagami : HHV-6の関与が疑われる後天性赤芽球癆の一例, 第66回中国四国小児科学会, Nov. 2014.
26.	Miho Sakata, Yasunobu Hayabuchi, 近藤朝美, 永井隆, Kazumi Okamura, Mayumi Sugimoto, Hiromichi Ito, Shuji Kondo, Hiroyoshi Watanabe and Shoji Kagami : 拡張型心筋症へ移行した急性壊死性好酸球性心筋炎の一例, 第23回日本小児心筋疾患学会, Oct. 2014.
27.	近藤朝美, 永井隆, Kazumi Okamura, Miho Sakata, Mayumi Sugimoto, Hiromichi Ito, Maki Urushihara, Hiroyoshi Watanabe, Yasunobu Hayabuchi and Shoji Kagami : 激症型心筋炎を来した特発性好酸球増多症の一例, 第142回日本小児科学会徳島地方会, Jun. 2014.
28.	Miho Sakata, Yasunobu Hayabuchi, 近藤朝美, 永井隆, Kazumi Okamura, Mayumi Sugimoto, Maki Urushihara, Shuji Kondo, Hiroyoshi Watanabe and Shoji Kagami : 経皮的心肺補助が必要であった急性壊死性好酸球性心筋炎の一例, 第63回徳島心エコー図研究会, May 2014.
29.	Kazumi Okamura, Hiroyoshi Watanabe, 近藤朝美, Nami Inoue, Toshihiko Nishisho and Shoji Kagami : 再生不良性貧血に対する同種造血幹細胞移植後に横紋筋肉腫を発症した1例, 第55回日本小児血液・がん学会, Nov. 2013.
30.	Nami Inoue, Hiroyoshi Watanabe, Kazumi Okamura and Shoji Kagami : 小児がん患者における腎機能評価として，血清クレアチニンによる糸球体濾過率推算式は有用か, 第55回日本小児血液・がん学会, Nov. 2013.
31.	万野朱美, Hiroyoshi Watanabe, 庄野実希, Kazumi Okamura, Nami Inoue, Ken-ichi Suga and Shoji Kagami : 脳梗塞後に多発脳転移と髄膜播種をきたした進行性横紋筋肉腫の1例, 第65回中国四国小児科学会, Nov. 2013.
32.	Nami Inoue, Hiroyoshi Watanabe, 市原裕子, 富本亜由美, Kazumi Okamura and Shoji Kagami : 3回目の同種造血幹細胞移植を施行した再発急性リンパ性白血病の1例, 第139回日本小児科学会徳島地方会, Dec. 2012.
33.	藤岡啓介, 富田理絵, 福留啓祐, 阿部容子, Yukiko Kinoshita, 市原朋子, 藤井笑子, 坂口善市, 幸山洋子, 関口隆憲, 大原克明, Kazumi Okamura, Hiroyoshi Watanabe and Shoji Kagami : 後天性サイトメガロウイルス感染症を契機に発症した治療抵抗性特発性血小板減少性紫斑病の1例, 第139回日本小児科学会徳島地方会, Dec. 2012.
34.	Hiroyoshi Watanabe, Nami Inoue, Kazumi Okamura and Shoji Kagami : 小児悪性腫瘍患者における発熱性好中球減少症(FN:febrile neutropenia)の病因や予後に関する検討, 第54回日本小児血液・がん学会, Dec. 2012.
35.	Nami Inoue, Hiroyoshi Watanabe, Kazumi Okamura, Tatsuya Ohnishi, Shoji Kagami and Teruyoshi Kageji : 尿崩症を合併した鞍上部未熟奇形腫の化学療法中に中枢性塩分喪失症候群を呈した症例, 第54回日本小児血液・がん学会, Dec. 2012.
36.	Kazumi Okamura, Hiroyoshi Watanabe, Nami Inoue, Teruyoshi Kageji and Shoji Kagami : 放射線治療を回避しえた退形成性上衣腫の乳児例, 第64回日本小児科学会中国四国地方会, Nov. 2012.
37.	富本亜由美, Nami Inoue, Hiroyoshi Watanabe, Kazumi Okamura, Ryuji Nakagawa and Shoji Kagami : サイトメガロウイルスに関連したITPの一例, 第138回日本小児科学会徳島地方会, Jun. 2012.
38.	Kazumi Okamura and Koji Yasutomo : CHD1T, )第11回四国免疫フォーラム, Jun. 2012.
39.	庄野実希, Nami Inoue, Kazumi Okamura, Hiroyoshi Watanabe, Shoji Kagami and 田山正伸 : ループスアンチコアグラント陽性，APTT 延長を一過性に認めた ITP の1例, 第137回日本小児科学会徳島地方会, Dec. 2011.
40.	Kazumi Okamura, Hiroyoshi Watanabe, 永井隆, 鈴江真史, Nami Inoue, Kazunori Sekine, Koichi Tamura and Shoji Kagami : 化学療法が奏功したMPNSTの一例, 第53回日本小児血液・がん学会, Nov. 2011.
41.	Nami Inoue, Hiroyoshi Watanabe, Kazumi Okamura, Toshihiro Ohnishi, Shoji Kagami and Teruyoshi Kageji : 鞍上部悪性胚細胞性腫瘍の治療中に，副腎皮質機能低下症に伴う高Ca血症を呈した2症例, 第53回日本小児血液・がん学会, Nov. 2011.
42.	苛原誠, Nami Inoue, Kazumi Okamura, Hiroyoshi Watanabe and Shoji Kagami : 右動眼神経麻痺で発症した atypical teratoid/rhabdoid tumorの一例, 第63回中国四国小児科学会, Nov. 2011.
43.	Hiroyoshi Watanabe, Kazumi Okamura, Nami Inoue, Shoji Kagami and 山田正 : 乳児期より頭蓋内出血を繰り返した血友病Aの男児例, 第3回四国血友病研究会, Sep. 2011.
44.	Nami Inoue, Hiroyoshi Watanabe, 阿部容子, 寺田知正, Kazumi Okamura and Shoji Kagami : 発症時に関節痛,骨量減少,骨形成低下を認めた急性リンパ性白血病の1例, 第136回日本小児科学会徳島地方会, Jun. 2011.
45.	Kazumi Okamura, Hiroyoshi Watanabe, Nami Inoue, Shoji Kagami, Ichiro Yokota and 金兼弘和 : 遺伝子解析にて診断が確定した Shwachman-Diamond 症候群の男児例, 第136回日本小児科学会徳島地方会, Jun. 2011.
46.	Hiroyoshi Watanabe, 苛原誠, Kazumi Okamura, Nami Inoue, 久山寿子, Hiroo Takehara, Shoji Kagami and 岡田要 : 劇症型肝障害とSOSを合併したWilms腫瘍の男児例, 平成22年度日本ウイルムス腫瘍スタディ研究会, Jan. 2011.
47.	Kazumi Okamura, Hiroyoshi Watanabe, 鈴江真史, Nami Inoue, Miho Sakata, Yukiko Kinoshita, Shuji Kondo, Yasunobu Hayabuchi, 清水真樹, Katsuyoshi Tamaki and Shoji Kagami : Fontan術後の肝過形成の2例, 第52回日本小児血液学会・第26回日本小児がん学会, Dec. 2010.

Et cetera, Workshop:

1.	森文香, Kazumi Okamura, Hiroyoshi Watanabe, Shoji Kagami, 畠田昇一, 中島公平, 溝渕佳史 and 高木康志 : 頭蓋内原発Ewing肉腫/pPNETの一例, 第151会日本小児科学会徳島地方会, Dec. 2018.
2.	Hiroyoshi Watanabe, Kazumi Okamura, 大隅敬太, 市原裕子 and Shoji Kagami : AYA 世代発症の治療抵抗性骨軟部腫瘍に対するPazopanib の使用経験, 第149回日本小児科学会徳島地方会, Dec. 2017.
3.	大隅敬太, Kazumi Okamura, Hiroyoshi Watanabe and Shoji Kagami : 同種造血幹細胞移植後にEBV再活性化による髄膜脳炎を呈した急性リンパ性白血病の一例, 第148回日本小児科学会徳島地方会, Jun. 2017.
4.	森輝実, 大豆本恵里名奈, Tatsuro Miyamoto, Mariko Egawa, Yoshinori Mitamura, 市原裕子, Kazumi Okamura and Hiroyoshi Watanabe : 再々発時に両眼性の漿液性網膜剥離を合併した急性リンパ性白血病の1例, 第77回徳島眼科集談会/2015.12.13/徳島, Dec. 2015.
5.	藤岡啓介, Hiroyoshi Watanabe, 市原裕子, Kazumi Okamura, Nami Inoue, Shoji Kagami and 郷司彩 : 腫瘍崩壊症候群の高リスクと考えられたT-ALLの2例, 第140回日本小児科学会徳島地方会, Jun. 2014.
6.	Nami Inoue, Hiroyoshi Watanabe, Kazumi Okamura, Shuji Kondo and Shoji Kagami : 小児がん患者における血清クレアチニンによる糸球体濾過率推算式の有用性に関する検討, 第141回日本小児科学会徳島地方会, Dec. 2013.
7.	万野朱美, Kazumi Okamura, 庄野実希, Nami Inoue, Hiroyoshi Watanabe, Shoji Kagami and Ken-ichi Suga : 脳梗塞を合併した進行性横紋筋肉腫の1例, 第140回日本小児科学会徳島地方会, Jun. 2013.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Utility of tumor-draining lymph nodes as new source of cell therapy for colorectal cancer patients (Project/Area Number: 20K16458 )
Search by Researcher Number (80768630)

Associate Professor : Okamura, Kazumi

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)