徳島大学 / 教育研究者総覧 --- 高麗雅章

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研究テーマ

著書・論文

学術論文(審査論文):

1.	Yasuhisa Kanematsu, Yuki Kanazawa, Kenji Shimada, Masaaki Korai, Takeshi Miyamoto, Shu Sogabe, Manabu Ishihara, Izumi Yamaguchi, Takeshi Oya, Nobuaki Yamamoto, Yuki Yamamoto, Miyoshi Mitsuharu, Masafumi Harada and Yasushi Takagi : Characterization of carotid plaques using chemical exchange saturation transfer imaging, Neuroradiology, Vol.66, No.9, 1617-1624, 2024. (要約) The preoperative assessment of carotid plaques is necessary to render revascularization safe and effective. The aim of this study is to evaluate the usefulness of chemical exchange saturation transfer (CEST)-MRI, particularly amide proton transfer (APT) imaging as a preoperative carotid plaque diagnostic tool. We recorded the APT signal intensity on concentration maps of 34 patients scheduled for carotid endarterectomy. Plaques were categorized into group A (APT signal intensity ≥ 1.90 E-04; n = 12) and group B (APT signal intensity < 1.90 E-04; n = 22). Excised plaques were subjected to histopathological assessment and, using the classification promulgated by the American Heart Association, they were classified as intraplaque hemorrhage-positive [type VI-positive (tVI)] and -negative [no intraplaque hemorrhage (tVI)]. Of the 34 patients, 22 (64.7%) harbored tVI- and 12 (35.3%) had tVI plaques. The median APT signals were significantly higher in tVI- than tIVI patients (2.43 E-04 (IQR = 0.98-4.00 E-04) vs 0.54 E-04 (IQR = 0.14-1.09 E-04), p < .001). Histopathologically, the number of patients with tVI plaques was significantly greater in group A (100%, n = 12) than group B (45%, n = 22) (p < .01). The number of symptomatic patients or asymptomatic patients with worsening stenosis was also significantly greater in group A than group B (75% vs 36%, p < .01). In unstable plaques with intraplaque hemorrhage and in patients with symptoms or progressive stenosis, the ATP signals were significantly elevated. CEST-MRI studies has the potential for the preoperative assessment of the plaques' characteristics. (キーワード) Humans / Male / Female / Aged / Carotid Stenosis / Magnetic Resonance Imaging / Middle Aged / Endarterectomy, Carotid / Plaque, Atherosclerotic / Sensitivity and Specificity / Image Interpretation, Computer-Assisted (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00234-024-03401-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38866959 ● Search Scopus @ Elsevier (PMID): 38866959 ● Search Scopus @ Elsevier (DOI): 10.1007/s00234-024-03401-3 (DOI: 10.1007/s00234-024-03401-3, PubMed: 38866959)
2.	Shu Sogabe, HABOSHI Tatsuya, Izumi Yamaguchi, Masaaki Korai, Nobuaki Yamamoto, Kenji Shimada, Yasuhisa Kanematsu and Yasushi Takagi : Experience of using coronary perfusion balloon catheter for acute middle cerebral artery occlusion, Surgical Neurology International, Vol.14, No.365, 365, 2023. (要約) We present the case of an individual with acute occlusion of the middle cerebral artery caused by atherosclerosis. The patient underwent angioplasty using a coronary perfusion balloon, which resulted in a favorable clinical outcome. A 66-year-old male patient presented with an acute onset of right hemiplegia and dysarthria. Magnetic resonance imaging revealed an occlusion of the left middle cerebral artery, and alteplase was administered, followed by a mechanical thrombectomy and intracranial balloon catheter angioplasty. Due to restenosis, a coronary perfusion balloon catheter was used for a 15-minute angioplasty procedure while maintaining the perfusion. This treatment approach led to the recanalization of the artery and favorable clinical outcomes. The coronary perfusion balloon may represent a viable therapeutic alternative for the management of refractory intracranial atherosclerotic large vessel occlusion. (徳島大学機関リポジトリ) ● Metadata: 119408 (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_608_2023 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37941628 ● CiNii @ 国立情報学研究所 (CRID): 1871146592942896128 ● Search Scopus @ Elsevier (PMID): 37941628 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_608_2023 (徳島大学機関リポジトリ: 119408, DOI: 10.25259/SNI_608_2023, PubMed: 37941628, CiNii: 1871146592942896128)
3.	Yuki Yamamoto, Nobuaki Yamamoto, Tomohiro Matsuda, Kazutaka Kuroda, Izumi Yamaguchi, Shu Sogabe, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi and Yuishin Izumi : Stent retrieval for free-floating thrombus attached to carotid artery stenosis: A report of two cases., Surgical Neurology International, Vol.14, 274, 2023. (要約) In cases of carotid artery stenosis with FFT, it is technically possible to retrieve a thrombus with a stent retriever. Although thrombus removal may help reduce the risk of ischemic complications in a series of urgent CAS procedures, there are concerns such as mechanical irritation to the carotid artery plaque, and its indications and alternative treatments should be carefully considered. (徳島大学機関リポジトリ) ● Metadata: 119409 (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_513_2023 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37680937 ● Search Scopus @ Elsevier (PMID): 37680937 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_513_2023 (徳島大学機関リポジトリ: 119409, DOI: 10.25259/SNI_513_2023, PubMed: 37680937)
4.	Natsumi Teshima, Kazuhito Matsuzaki, Noriya Enomoto, Masaaki Korai, Yoshitaka Kurashiki, Mami Hanaoka, Hitoshi Niki and Koichi Satoh : Case of Cerebrospinal Fluid Leakage Nine Years after Pituitary Gamma Knife Surgery for Poststroke Thalamic Pain Syndrome., NMC Case Report Journal, Vol.10, 209-213, 2023. (要約) Pituitary gamma knife surgery (GKS) is a treatment option for poststroke thalamic pain syndrome. Complications such as hypopituitarism, transient enuresis, and transient hyponatremia have been reported. However, cerebrospinal fluid (CSF) leakage has not yet been reported as a complication of pituitary GKS for poststroke thalamic pain syndrome. Herein, we report a case of delayed CSF rhinorrhea that developed 9 years after GKS for poststroke thalamic pain syndrome. A 64-year-old man presented to our hospital with bacterial meningitis and CSF rhinorrhea. Pituitary GKS for poststroke thalamic pain had been performed 9 years prior to his admission to our hospital. Computed tomography revealed pneumocephalus, fluid in the sphenoid and maxillary sinuses, and a partial bony defect of the sella turcica floor with communication between the paranasal and intracranial spaces. The CSF rhinorrhea resolved with bed rest and a lumbar CSF drain but recurred several days later. The patient underwent direct endoscopic surgical repair of the skull base. The sellar floor was covered with an autologous fascia graft harvested from the rectus sheath, and the sphenoid sinus was packed with abdominal fat grafts. The patient recovered, and the CSF rhinorrhea has not recurred for 2 years. Long-term follow-up is necessary after pituitary GKS, considering the complication of delayed CSF leakage. (徳島大学機関リポジトリ) ● Metadata: 119563 (出版サイトへのリンク) ● Publication site (DOI): 10.2176/jns-nmc.2022-0224 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37539363 ● Search Scopus @ Elsevier (PMID): 37539363 ● Search Scopus @ Elsevier (DOI): 10.2176/jns-nmc.2022-0224 (徳島大学機関リポジトリ: 119563, DOI: 10.2176/jns-nmc.2022-0224, PubMed: 37539363)
5.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 循環器病を防ぐために徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, 四国医学雑誌, Vol.78, No.5-6, 135-138, 2022年. (要約) Cerebrovascular and cardiovascular disease are the main causes of death in Japan. The leading causes of the need for long-term care in Japan are also cerebrovascular and cardiovascular disease, which together account for more than one-fourth of the total. The Cerebrovascular and Cardiovascular Disease Control Act, of Japanese national law, was promulgated by a legislative act in 2018. On the basis of the Cerebrovascular and Cardiovascular Disease Control Act, the Ministry of Health, Labour and Welfare, Japan, published the Japanese National Plan for Promotion of Measures Against Cerebrovascular and Cardiovascular Disease (Japanese National Plan) in 2020. By the example of the Japanese National Plan, Tokushima prefecture established a cerebrovascular and cardiovascular disease countermeasure promotion plan to progress cerebrovascular and cardiovascular disease measures according to their own circumstances. One of the important measures of the plan is improving emergency transportation systems. Patients with intracranial large vessel occlusion strokes should be served by direct transfer to endovascular capable centers avoiding delays by misguided transfer to primary stroke centers. Considering the limited availability of endovascular capable centers, accurate identification of patients with high probability of having large vessel occlusion strokes in the prehospital setting is importance. To address this problem, we introduced prehospital scale called Field Assessment Stroke Triage for Emergency Destination (FAST-ED) on emergency transportation systems in Tokushima city. (キーワード) Cerebrovascular and cardiovascular disease / emergency transportation systems / prehospital scale (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520858387633637376 (CiNii: 1520858387633637376)
6.	山本雄貴, 山本伸昭, 黒田一駿, 和泉唯信, 兼松康久, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志 : 徳島市におけるアプリケーションを用いた脳主幹動脈閉塞診断スケールの活用,, 四国医学雑誌, Vol.78, No.5,6, 248-249, 2022年.
7.	Kenji Shimada, Kazuhisa Miyake, Izumi Yamaguchi, Shu Sogabe, Masaaki Korai, Yasuhisa Kanematsu and Yasushi Takagi : Efficacy of Utilizing Both 3-Dimensional Multimodal Fusion Image and Intra-Arterial Indocyanine Green Videoangiography in Cerebral Arteriovenous Malformation Surgery, World Neurosurgery, Vol.169, e260-e269, 2022. (要約) An understanding of the complex morphology of an arteriovenous malformation (AVM) is important for successful resection. We have previously reported the utility of intra-arterial indocyanine green (ICG) videoangiography for this purpose, but that method cannot detect the angioarchitecture covered by brain tissue. 3-dimensional (3D) multimodal fusion imaging is reportedly useful for this same purpose, but cannot always visualize the exact angioarchitecture due to poor source images and processing techniques. This study examined the results of utilizing both techniques in patients with AVMs. Both techniques were applied in 12 patients with AVMs. Both images were compared with surgical views and evaluated by surgeons. Although evaluations for identifying superficial feeders by ICG videoangiography were high in all cases, the more complicated the AVM, the lower the evaluation by 3D multimodal fusion imaging. Conversely, evaluation of the estimated range of the nidus was high in all cases by 3D multimodal fusion imaging, but low in all but one case by ICG videoangiography. Nidus flow reduction was recognized by Flow 800 analysis obtained after ICG videoangiography. These results showed that utilizing both techniques together was more useful than each modality alone in AVM surgery. This was particularly effective in identifying superficial feeders and estimating the range of the nidus. This technique is expected to offer an optimal tool for AVM surgery. (徳島大学機関リポジトリ) ● Metadata: 118079 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.wneu.2022.10.121 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36332776 ● Search Scopus @ Elsevier (PMID): 36332776 ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2022.10.121 (徳島大学機関リポジトリ: 118079, DOI: 10.1016/j.wneu.2022.10.121, PubMed: 36332776)
8.	Masaaki Korai, Noriya Enomoto, Koichi Satoh, Shunji Matsubara, Yasuhisa Kanematsu, Tadashi Yamaguchi, Mami Hanaoka, Hitoshi Niki, Kazuhito Matsuzaki, Koji Bando, Hirotaka Hagino and Yasushi Takagi : Transarterial embolization for convexity dural arteriovenous fistula with or without pial arterial supply: A report of four patients, Surgical Neurology International, Vol.13, No.340, 1-6, 2022. (徳島大学機関リポジトリ) ● Metadata: 117905 (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_215_2022 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_215_2022 (徳島大学機関リポジトリ: 117905, DOI: 10.25259/SNI_215_2022)
9.	Tadashi Yamaguchi, Takeshi Miyamoto, Eiji Shikata, Izumi Yamaguchi, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Masaaki Korai, Keiko T. Kitazato, Yasuhisa Kanematsu and Yasushi Takagi : Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats, Journal of Neurosurgery, 1-8, 2022. (要約) Subarachnoid hemorrhage (SAH) due to intracranial aneurysm (IA) rupture is often a devastating event. Since the incidence of SAH increases especially in menopause, it is crucial to clarify the detailed pathogenesis of these events. The activation of vascular nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes has been studied in ischemic stroke and cardiovascular disease. However, the role of NLRP3 in IA rupture still needs to be explained. The authors sought to test their hypothesis that, under estrogen-deficient conditions, activation of NLRP3 inflammasomes via downregulation of the estrogen receptor (ER) facilitates IA rupture. Ten-week-old female Sprague Dawley rats with and without oophorectomy were subjected to hemodynamic changes and hypertension (OVX+/HT and OVX-/HT, respectively) and fed a high-salt diet. Separately, using human brain endothelial cells (HBECs) and human brain smooth muscle cells (HBSMCs), the authors tested the effect of NLRP3 under estrogen-free conditions and in the presence of estradiol or of ER agonists. In OVX+/HT rats, the frequency of IA rupture was significantly higher than in OVX-/HT rats (p = 0.03). In the left posterior cerebral artery prone to rupture in OVX+/HT rats, the levels of the mRNAs encoding ERα and Sirt1, but not of that encoding ERβ, were decreased, and the levels of the mRNAs encoding NLRP3, interleukin-1β (IL-1β), and matrix metalloproteinase 9 (MMP-9) were elevated. Immunohistochemical analysis demonstrated that the expression profiles of these proteins correlated with their mRNA levels. Treatment with an ER modulator, bazedoxifene, normalized the expression profiles of these proteins and improved SAH-free survival. In HBECs and HBSMCs under estrogen-free conditions, the depletion of ERα and Sirt1 and the accumulation of NLRP3 were counteracted by exposure to estradiol or to an ERα agonist but not to an ERβ agonist. To the authors' knowledge, this work represents the first demonstration that, in an aneurysm model under estrogen-deficient conditions, the depletion of ERα and Sirt1 may contribute to activation of the NLRP3/IL-1β/MMP-9 pathway, facilitating the rupture of IAs in the estrogen-deficient rat IA rupture model. (徳島大学機関リポジトリ) ● Metadata: 117700 (出版サイトへのリンク) ● Publication site (DOI): 10.3171/2022.4.JNS212945 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35594890 ● Search Scopus @ Elsevier (PMID): 35594890 ● Search Scopus @ Elsevier (DOI): 10.3171/2022.4.JNS212945 (徳島大学機関リポジトリ: 117700, DOI: 10.3171/2022.4.JNS212945, PubMed: 35594890)
10.	Eiji Shikata, Izumi Yamaguchi, Masaaki Korai, Takeshi Miyamoto, Tadashi Yamaguchi, Hiroshi Kagusa, Kenji Shimada, Yoshiteru Tada, Keiko Kitazato, Yasuhisa Kanematsu and Yasushi Takagi : Could clazosentan, first approved in Japan, improve neurological prognosis after subarachnoid hemorrhage in combination with modified water-electrolyte management?, Brain Hemorrhages, Vol.137, No.6, 1707-1717, 2022. (徳島大学機関リポジトリ) ● Metadata: 118951 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.hest.2023.10.005 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85175417356 (徳島大学機関リポジトリ: 118951, DOI: 10.1016/j.hest.2023.10.005, Elsevier: Scopus)
11.	Masaaki Korai, Yasuhisa Kanematsu, Izumi Yamaguchi, Tadashi Yamaguchi, Yuki Yamamoto, Nobuaki Yamamoto, Takeshi Miyamoto, Kenji Shimada, Junichiro Satomi, Mami Hanaoka, Kazuhito Matsuzaki, Koichi Satoh and Yasushi Takagi : Subarachnoid Hemorrhage Due to Rupture of Vertebral Artery Dissecting Aneurysms: Treatments, Outcomes, and Prognostic Factors, World Neurosurgery, Vol.152, e86-e93, 2021. (要約) Mortality rate after subarachnoid hemorrhage due to rupture of vertebral artery dissecting aneurysms (VADAs) is high; endovascular coil trapping is the first-line therapy to prevent rerupture. To select optimal treatments, the positional relationship between the VADA and posterior inferior cerebellar artery (PICA) and the morphology of the contralateral vertebral artery must be considered, and outcome predictors of different treatment methods and their possible complications must be identified. We retrospectively studied 44 patients with ruptured VADAs who had undergone endovascular or surgical treatment. VADA morphology was assessed on conventional preoperative angiograms, and VADAs were categorized based on their site in relation to the PICA. VADA site, treatment method, and complications were used to identify prognostic factors. The sites of the 44 VADAs were PICA-proximal (n = 3), PICA-distal (n = 22), PICA-absent (n = 7), and PICA-involved (n = 12). Treatments included internal coil trapping (n = 30), proximal coil occlusion (n = 5), and stent placement (n = 3); surgical flow alteration via an occipital artery-PICA bypass and ligation at the proximal vertebral artery and the PICA origin was performed in 6 patients. Periprocedural rebleeding was associated with a poor outcome. Internal coil trapping prevented the rerupture of PICA-proximal and PICA-absent VADAs, and flow alteration prevented rerupture of PICA-involved VADAs; there were no complications directly attributable to these procedures. Periprocedural rebleeding was a poor prognostic factor. Internal trapping of PICA-proximal and PICA-absent VADAs and flow alteration in PICA-involved VADAs prevented rerupture. (キーワード) Adult / Aged / Aged, 80 and over / Aneurysm, Ruptured / Follow-Up Studies / Humans / Male / Middle Aged / Prognosis / Retrospective Studies / Subarachnoid Hemorrhage / Treatment Outcome / Vertebral Artery Dissection (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.wneu.2021.05.018 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34051365 ● Search Scopus @ Elsevier (PMID): 34051365 ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2021.05.018 (DOI: 10.1016/j.wneu.2021.05.018, PubMed: 34051365)
12.	Yasuhisa Kanematsu, Kenji Shimada, Yoshiteru Tada, Masaaki Korai, Takeshi Miyamoto, Shu Sogabe, Izumi Yamaguchi, Yoko Ymamoto, Nobuaki Yamamoto, Yuki Yamamoto, Koichi Satoh and Yasushi Takagi : Coil embolization with overlapping horizontal low-profile stents to treat a giant thrombosed fetal posterior cerebral aneurysm using contralateral approach through anterior communicating artery: Case report., Surgical Neurology International, Vol.12, No.347, 2021. (要約) The treatment of internal carotid artery (ICA) - posterior communicating artery aneurysms (ICPC aneurysms) is challenging when a fetal posterior cerebral artery (PCA) arises from the saccular neck. This complex angioarchitecture renders endovascular approaches difficult. Giant thrombosed IC-PC aneurysms are also hard to treat by endovascular coiling because its flow-diversion effect is insufficient. We report the first case of a ruptured giant thrombosed IC-PC aneurysm associated with a fetal PCA that was successfully treated by coil embolization with retrograde overlap horizontal stenting using low-profile stents introduced through the contralateral ICA. The aneurysm was completely occluded and follow-up MRI scans demonstrated the reduction of the aneurysmal size. Our technique is advantageous because low-profile stents can be used to treat lesions not accessible with flow-diverter stents due their presence in complex angioarchitectures, and overlap stenting may have flow-diversion effects that can result in the complete occlusion of giant thrombosed aneurysms. (徳島大学機関リポジトリ) ● Metadata: 119411 (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_533_2021 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34345487 ● Search Scopus @ Elsevier (PMID): 34345487 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_533_2021 (徳島大学機関リポジトリ: 119411, DOI: 10.25259/SNI_533_2021, PubMed: 34345487)
13.	Masaaki Korai, Purcell James, Kamio Yoshinobu, Mitsui Kazuha, Furukawa Hajime, Yokosuka Kimihiko, Takeshi Miyamoto, Sato Hitomi, Eguchi Satoru, Ai Jingle, Lowton T. Micheal and Hashimoto Tomoki : Neutrophil Extacellular Traps Promote the Development of Intracranial Aneurysm Rupture., Hypertension, Vol.77, No.6, 2084-2093, 2021. (要約) [Figure: see text]. (キーワード) Aneurysm, Ruptured / Animals / Brain / Extracellular Traps / Humans / Intracranial Aneurysm / Mice (出版サイトへのリンク) ● Publication site (DOI): 10.1161/HYPERTENSIONAHA.120.16252 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33813846 ● Search Scopus @ Elsevier (PMID): 33813846 ● Search Scopus @ Elsevier (DOI): 10.1161/HYPERTENSIONAHA.120.16252 (DOI: 10.1161/HYPERTENSIONAHA.120.16252, PubMed: 33813846)
14.	Shotaroh Yoshioka, Takeshi Miyamoto, Junichiro Satomi, Yoshiteru Tada, Kenji Yagi, Kenji Shimada, Koji Naruishi, Eiji Shikata, Izumi Yamaguchi, Tadashi Yamaguchi, Masaaki Korai, Yoshihiro Okayama, Masafumi Harada, Keiko Kitazato, Yasuhisa Kanematsu, Shinji Nagahiro and Yasushi Takagi : Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage, Neurosurgery Open, Vol.1, No.3, 1-9, 2020. (徳島大学機関リポジトリ) ● Metadata: 115292 (出版サイトへのリンク) ● Publication site (DOI): 10.1093/neuopn/okaa007 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1093/neuopn/okaa007 (徳島大学機関リポジトリ: 115292, DOI: 10.1093/neuopn/okaa007)
15.	Koji Bando, Toshiyuki Okazaki, Hideo Mure, Masaaki Korai and Hiroshi Kagusa : A Juvenile Case of Bow Hunter's Syndrome Caused by Atlantoaxial Dislocation with Vertebral Artery Dissecting Aneurysm., World Neurosurgery, Vol.137, 393-397, 2020. (要約) Bow hunter's syndrome (BHS) is caused by posterior circulation insufficiency that results from the occlusion or compression of the vertebral artery (VA) during neck rotation. Owing to its rarity, there is no guideline to support the decision of selecting a conservative or a surgical approach. Management of BHS is dependent on each patient. A 13-year-old girl presented with transient visual disturbance, hypoesthesia, and paralysis of the left side of the body. Magnetic resonance imaging revealed an acute cerebral infarction in the right thalamus, and magnetic resonance angiography demonstrated occlusion of the right posterior cerebral artery and dilation of V3 of the left VA. Digital subtraction angiography revealed a left VA dissecting aneurysm at V3 and left VA occlusion at the level of C1-C2 during neck rotation to the right. A dynamic x-ray suggested atlantoaxial joint instability, and three-dimensional computed tomography revealed aplasia of C1 lamina and atlantoaxial rotatory dislocation. BHS with left VA dissecting aneurysm caused by atlantoaxial rotatory dislocation was diagnosed. We performed C1-C2 posterior fusion by the Goel-Harms technique. Stroke did not recur, and computed tomography angiography obtained 8 months postoperatively demonstrated a decrease in the dissecting aneurysm. To our knowledge, this is the first case of BHS with VA dissecting aneurysm and aplasia of C1 lamina. Based on this case, we suggest that C1-C2 posterior fusion is effective for BHS with VA dissecting aneurysm. (キーワード) Adolescent / Aneurysm, Dissecting / Atlanto-Axial Joint / Cervical Atlas / Computed Tomography Angiography / 女性 (female) / Humans / Imaging, Three-Dimensional / Infarction, Posterior Cerebral Artery / Joint Dislocations / Magnetic Resonance Angiography / Rotation / Spinal Fusion / Vertebral Artery Dissection / Vertebrobasilar Insufficiency (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.wneu.2020.02.041 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32068175 ● Search Scopus @ Elsevier (PMID): 32068175 ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2020.02.041 (DOI: 10.1016/j.wneu.2020.02.041, PubMed: 32068175)
16.	Nobuaki Yamamoto, Yuki Yamamoto, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yuishin Izumi and Yasushi Takagi : Cone beam-computed tomography angiography by intravenous contrast injection is reliable to evaluate patients with large vessel occlusion, Journal of Clinical Neuroscience, Vol.70, 67-71, 2019. (要約) Mechanical thrombectomy (MT) for acute ischemic stroke (AIS) patients due to emergent large vessel occlusion (ELVO) is standard treatment, the benefits, however, are highly time-sensitive. After patient eligibility for reperfusion therapy is determined by conventional radiological examinations, the time to be transferred from the department of radiological examination to angiography-suites is critical. We speculated that the time required for the diagnosis of AIS might be reduced if we could determine MT eligibility in patients with ELVO at angiography-suites. Modern angiography-suites with flat panel detectors can perform cone beam (CB)-CT. We performed CB-CTA using intravenous injection of contrast agent to evaluate occlusion sites, collateral score, and construction of vessels distal to occlusion sites and determined if CB-CTA could be useful to evaluate patients with ELVO. We included 15 patients with ELVO diagnosed by conventional MRI or CT/CTA, and investigated whether CB-CTA was reliable to diagnose occlusion sites. We also studied if collateral score on CB-CTA was associated with prognosis after successful reperfusion by MT by comparison between favorable (modified Rankin scale (mRS) 0-2), and unfavorable outcome group (mRS 3-6). There was strong agreement of occlusion sites between CB-CTA and conventional radiological examination (κ = 0.80). Collateral score determined by CB-CTA was significantly different between favorable outcome and unfavorable outcome group (median collateral score 2.3 v.s. 1.3, p = 0.040). Although prospective study of AIS patients at a radiography department is indispensable, CB-CTA performed in an angiography-suite might be useful to evaluate patients with ELVO. (キーワード) Aged / Aged, 80 and over / Brain Ischemia / Carotid Artery Thrombosis / Computed Tomography Angiography / Contrast Media / Female / Humans / Infarction, Middle Cerebral Artery / Injections, Intravenous / Male / Middle Aged / Prognosis / Reperfusion / Retrospective Studies / Thrombectomy / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jocn.2019.08.078 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31445814 ● Summary page in Scopus @ Elsevier: 2-s2.0-85070874852 (DOI: 10.1016/j.jocn.2019.08.078, PubMed: 31445814, Elsevier: Scopus)
17.	Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Masaaki Korai, Takeshi Miyamoto, Eiji Shikata, Tadashi Yamaguchi, Nobuaki Yamamoto, Yuki Yamamoto, Keiko Kitazato, Yoshihiro Okayama and Yasushi Takagi : Active Cancer and Elevated D-Dimer Are Risk Factors for In-Hospital Ischemic Stroke, Cerebrovascular Diseases Extra, Vol.9, No.3, 129-138, 2019. (要約) Little attention has been paid to the pathogenesis of in-hospital stroke, despite poor outcomes and a longer time from stroke onset to treatment. We studied the pathophysiology and biomarkers for detecting patients who progress to in-hospital ischemic stroke (IHS). Seventy-nine patients with IHS were sequentially recruited in the period 2011-2017. Their characteristics, care, and outcomes were compared with 933 patients who had an out-of-hospital ischemic stroke (OHS) using a prospectively collected database of the Tokushima University Stroke Registry. Active cancer and coronary artery disease were more prevalent in patients with IHS than in those with OHS (53.2 and 27.8% vs. 2.0 and 10.9%, respectively; p < 0.001), the median onset-to-evaluation time was longer (300 vs. 240 min; p = 0.015), and the undetermined etiology was significantly higher (36.7 vs. 2.4%; p < 0.001). Although there was no significant difference in stroke severity at onset between the groups, patients with IHS had higher modified Rankin Scale (mRS) scores (3-6) at discharge (67.1 vs. 50.3%; p = 0.004) and rates of death during hospitalization (16.5 vs. 2.9%; p < 0.001). D-dimer (5.8 vs. 0.8 µg/mL; p < 0.001) and fibrinogen (532 vs. 430 mg/dL; p = 0.014) plasma levels at the time of onset were significantly higher in patients with IHS after propensity score matching. Multivariate logistic regression analysis revealed that active cancer (odds ratio [OR] 2.30; 95% confidence interval [CI] 1.26-4.20), prestroke mRS scores 3-5 (OR 6.78; 95% CI 3.96-11.61), female sex (OR 1.57; 95% CI 1.19-2.08), and age ≥75 years (OR 2.36; 95% CI 1.80-3.08) were associated with poor outcomes. Patients with IHS had poorer outcomes than those with OHS because of a higher prevalence of active cancer and functional dependence before stroke onset. Elevated plasma levels of D-dimer and fibrinogen, especially with active cancer, can help identify patients who are at a higher risk of progression to IHS. (キーワード) Aged / Aged, 80 and over / Biomarkers / Brain Ischemia / Databases, Factual / 女性 (female) / Fibrin Fibrinogen Degradation Products / Hospital Mortality / Hospitalization / Humans / Inpatients / 日本 (Japan) / 男性 (male) / Middle Aged / Neoplasms / Prevalence / Prognosis / Registries / Retrospective Studies / Risk Assessment / Risk Factors / Stroke / Time Factors / Up-Regulation (徳島大学機関リポジトリ) ● Metadata: 115057 (出版サイトへのリンク) ● Publication site (DOI): 10.1159/000504163 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31760390 ● Summary page in Scopus @ Elsevier: 2-s2.0-85075786196 (徳島大学機関リポジトリ: 115057, DOI: 10.1159/000504163, PubMed: 31760390, Elsevier: Scopus)
18.	Tadashi Yamaguchi, Takeshi Miyamoto, keiko Kitazato, Eiji Shikata, Izumi Yamaguchi, Masaaki Korai, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Yoshihito Matsuzaki, Yasuhisa Kanematsu and Yasushi Takagi : Time-dependent and site-dependent morphological changes in rupture-prone arteries: ovariectomized rat intracranial aneurysm model, Journal of Neurosurgery, 2019. (要約) The pathogenesis of intracranial aneurysm rupture remains unclear. Because it is difficult to study the time course of human aneurysms and most unruptured aneurysms are stable, animal models are used to investigate the characteristics of intracranial aneurysms. The authors have newly established a rat intracranial aneurysm rupture model that features site-specific ruptured and unruptured aneurysms. In the present study the authors examined the time course of changes in the vascular morphology to clarify the mechanisms leading to rupture. Ten-week-old female Sprague-Dawley rats were subjected to hemodynamic changes, hypertension, and ovariectomy. Morphological changes in rupture-prone intracranial arteries were examined under a scanning electron microscope and the association with vascular degradation molecules was investigated. At 2-6 weeks after aneurysm induction, morphological changes and rupture were mainly observed at the posterior cerebral artery; at 7-12 weeks they were seen at the anterior Willis circle including the anterior communicating artery. No aneurysms at the anterior cerebral artery-olfactory artery bifurcation ruptured, suggesting that the inception of morphological changes is site dependent. On week 6, the messenger RNA level of matrix metalloproteinase-9, interleukin-1β, and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of metalloproteinase-2 was significantly higher at the posterior cerebral artery, but not at the anterior communicating artery, of rats with aneurysms than in sham-operated rats. These findings suggest that aneurysm rupture is attributable to significant morphological changes and an increase in degradation molecules. Time-dependent and site-dependent morphological changes and the level of degradation molecules may be indicative of the vulnerability of aneurysms to rupture. (徳島大学機関リポジトリ) ● Metadata: 113804 (出版サイトへのリンク) ● Publication site (DOI): 10.3171/2019.6.JNS19777 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31518986 ● Search Scopus @ Elsevier (PMID): 31518986 ● Search Scopus @ Elsevier (DOI): 10.3171/2019.6.JNS19777 (徳島大学機関リポジトリ: 113804, DOI: 10.3171/2019.6.JNS19777, PubMed: 31518986)
19.	Toshiyuki Okazaki, Yasuhisa Kanematsu, Kenji Shimada, Masaaki Korai, Junichiro Satomi, Masaaki Uno, Shinji Nagahiro and Yasushi Takagi : A Single-center Retrospective Study with 5- and 10-year Follow-up of Carotid Endarterectomy with Patch Graft., Neurologia Medico-Chirurgica, Vol.59, No.6, 231-237, 2019. (要約) Carotid endarterectomy (CEA) is widely used for cervical artery stenosis. In Japan, primary closure after endarterectomy has been a standard technique. Recently, the patch closure has been shown to be superior to the primary suture for the prevention of restenosis and ipsilateral stroke. This study evaluated the 5- and 10-year outcomes following CEA with patch graft closure in our institution. Between January 2000 and March 2013, 134 patients, who underwent CEA with patch graft closure were investigated in the current retrospective study. Among these patients, 102 CEAs in 97 patients were followed up for 5 years and 66 CEAs in 61 patients were for 10 years after the procedure. Restenosis was defined as >50% recurrent luminal narrowing at the endarterectomy site. In 5 years, symptomatic restenosis exhibited minor stroke in one patient at 58 months after CEA (restenosis rate 1.0%). The ipsilateral minor stroke occurred in three patients including the above case (2.9%). In 10 years, asymptomatic restenosis occurred in three patients in addition to the above symptomatic case (restenosis rate 6.1%), and the ipsilateral minor stroke occurred in four patients (6.1%). Carotid endarterectomy with patch graft exerted a high protective effect from restenosis up to 5 and 10 years in our institution. The number of carotid artery stenting is increasing all over the world but we speculated that the established surgical procedure of patched CEA prevented restenosis and ipsilateral stroke. (キーワード) Aged / Blood Vessel Prosthesis Implantation / Carotid Stenosis / Endarterectomy, Carotid / Female / Follow-Up Studies / Graft Occlusion, Vascular / Humans / Male / Middle Aged / Postoperative Complications / Retrospective Studies / Stents / Stroke / Time Factors (徳島大学機関リポジトリ) ● Metadata: 119185 (出版サイトへのリンク) ● Publication site (DOI): 10.2176/nmc.oa.2018-0309 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31061257 ● Search Scopus @ Elsevier (PMID): 31061257 ● Search Scopus @ Elsevier (DOI): 10.2176/nmc.oa.2018-0309 (徳島大学機関リポジトリ: 119185, DOI: 10.2176/nmc.oa.2018-0309, PubMed: 31061257)
20.	Yamamoto Yuki, Nobuaki Yamamoto, Yasuhisa Kanematsu, Masaaki Korai, Kenji Shimada, Yuishin Izumi and Yasushi Takagi : The Claw Sign: An angiographic Predictor of Recanalization After Mechanical Thrombectomy for Cerebral Large Vessel Occlusion., Journal of Stroke & Cerebrovascular Diseases, Vol.28, No.6, 1555-1560, 2019. (要約) Mechanical thrombectomy undoubtedly improves functional outcomes for patients with acute ischemic stroke. Although we have observed occlusion sites that protrude proximally into the vessel on angiography, termed the "claw sign," we have been unable to state its clinical significance. In this study, we aimed to determine whether the presence of a claw sign was related to recanalization success after mechanical thrombectomy. We retrospectively included 73 consecutive patients treated for acute cerebral large vessel occlusion by mechanical thrombectomy between January 2014 and December 2017. The angiographic claw sign was defined as a thrombus that protruded proximally by more than half the diameter of the parent artery. Claw sign positivity, clinical and etiological features, and outcomes were compared between groups with and without recanalization. The claw sign was observed in 29 of 73 (40%) patients and was positive significantly more frequently in those with recanalization (50.0%) than in those without recanalization (5.9%) (P < .01). By multivariate analysis, the claw sign was the only pretreatment parameter to predict successful recanalization (odds ratio, 12.50; 95% confidence interval, 1.50-103.00; P = .019). The presence of the claw sign might predict successful recanalization in patients undergoing mechanical thrombectomy for large vessel occlusion. (キーワード) Aged / Aged, 80 and over / Angiography, Digital Subtraction / Cerebral Angiography / Cerebral Arteries / Cerebrovascular Circulation / Constriction, Pathologic / Female / Humans / Intracranial Thrombosis / Male / Middle Aged / Predictive Value of Tests / Retrospective Studies / Thrombectomy / Thrombolytic Therapy / Treatment Outcome / Vascular Patency (徳島大学機関リポジトリ) ● Metadata: 114639 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2019.03.007 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30930237 ● Search Scopus @ Elsevier (PMID): 30930237 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jstrokecerebrovasdis.2019.03.007 (徳島大学機関リポジトリ: 114639, DOI: 10.1016/j.jstrokecerebrovasdis.2019.03.007, PubMed: 30930237)
21.	Akemi Hioka, Yoshiteru Tada, Keiko Kitazato, Yasuhisa Kanematsu, Yoshifumi Mizobuchi, Hideo Mure, Kenji Shimada, Toshiyuki Okazaki, Masaaki Korai, Noki Akazawa, Yuki Matsumoto, Yuki Matsumoto, Yasushi Takagi and Shinji Nagahiro : Activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons., Journal of Clinical Neuroscience, Vol.60, 79-83, 2019. (要約) The observation of walking improves gait ability in chronic stroke survivors. It has also been suggested that activation of the mirror neuron system contributes to this effect. However, activation of the mirror neuron system during gait observation has not yet been assessed in sub-acute stroke patients. The objective of this study was to clarify the activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons. In this study, we sequentially enrolled five sub-acute stroke patients who had undergone gait training and nine healthy persons. We used fMRI to detect neuronal activation during gait observation. During the observation period in the stroke group, neural activity in the left inferior parietal lobule, right and left inferior frontal gyrus was significantly higher than during the rest period. In the healthy group, neural activity in the left inferior parietal lobule, left inferior frontal gyrus, left middle frontal gyrus, left superior temporal lobule and right and left middle temporal gyrus was significantly higher than during the rest period. The results indicate that the mirror neuron system was activated during gait observation in sub-acute stroke patients who had undergone gait training and also in healthy persons. Our findings suggest that gait observation treatment may provide a promising therapeutic strategy in sub-acute stroke patients who have experienced gait training. (キーワード) Adult / Brain / Exercise Therapy / Female / Gait / Humans / Magnetic Resonance Imaging / Male / Middle Aged / Mirror Neurons / Stroke / Stroke Rehabilitation (徳島大学機関リポジトリ) ● Metadata: 113267 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jocn.2018.09.035 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30318398 ● Search Scopus @ Elsevier (PMID): 30318398 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jocn.2018.09.035 (徳島大学機関リポジトリ: 113267, DOI: 10.1016/j.jocn.2018.09.035, PubMed: 30318398)
22.	Nobuaki Yamamoto, Yuki Yamamoto, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yuishin Izumi, Junichiro Satomi, Yasushi Takagi and Ryuji Kaji : Simultaneous approach to tandem occlusion in acute ischemic stroke patients: Percutaneous Transluminal Angioplasty (PTA) using push wire of stent retriever, Journal of Neuroendovascular Therapy, Vol.13, No.6, 257-261, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.5797/jnet.cr.2018-0108 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001288147947776 ● Search Scopus @ Elsevier (DOI): 10.5797/jnet.cr.2018-0108 (DOI: 10.5797/jnet.cr.2018-0108, CiNii: 1390001288147947776)
23.	Shinji Nagahiro, Yoshiteru Tada, Junichiro Satomi, Tomoya Kinouchi, Kazuyuki Kuwayama, Kenji Yagi, Kohhei Nakajima, Nobuhisa Matsushita, Takeshi Miyamoto, Tadashi Yamaguchi, Kenji Shimada, Masaaki Korai, Hideo Mure, Y Okayama, Takashi Abe, Masafumi Harada, Keiko T. Kitazato and Yasuhisa Kanematsu : Treatment of Unruptured Cerebral Aneurysms with the Mineralocorticoid Receptor Blocker Eplerenone-Pilot Study., Journal of Stroke & Cerebrovascular Diseases, Vol.27, No.8, 2134-2140, 2018. (要約) Currently there are no pharmacological therapies for patients with unruptured cerebral aneurysms. Elsewhere we showed that the mineralocorticoid receptor antagonist eplerenone prevented the formation of cerebral aneurysms in our ovariectomized hypertensive aneurysm rat model. The current pilot study evaluated whether it can be used to prevent the growth and rupture of cerebral aneurysms in hypertensive patients. Between August 2011 and May 2014, we enrolled 82 patients with 90 aneurysms in an open-label uncontrolled clinical trial. All provided prior informed consent for inclusion in this study, and all were treated with eplerenone (25-100 mg/d). The primary end points of our study were the rupture and enlargement of the cerebral aneurysms. Of the 82 patients, 80 (88 unruptured aneurysms) were followed for a mean of 21.3 months (153.4 aneurysm-years); 12 patients (15.0%) permanently discontinued taking the drug. One month after the start of eplerenone administration and throughout the follow-up period, eplerenone kept the blood pressure within the normal range. Most notably, no aneurysms smaller than 9 mm ruptured or enlarged. However, of 2 large thrombosed aneurysms, 1 enlarged and the other ruptured. The overall annual rupture rate was .65%; it was 13.16% for aneurysms larger than 10 mm; the overall annual rate for reaching the primary end points was 1.30%. Our observations suggest that eplerenone may help to prevent the growth and rupture of unruptured cerebral aneurysms smaller than 9 mm. To assess its potential long-term clinical benefits, large clinical trials are needed. (キーワード) Aged / Aneurysm, Ruptured / 脳 (brain) / Disease Progression / 女性 (female) / Follow-Up Studies / Humans / Intracranial Aneurysm / 男性 (male) / Mineralocorticoid Receptor Antagonists / Neuroprotective Agents / Pilot Projects / Spironolactone / Treatment Outcome (徳島大学機関リポジトリ) ● Metadata: 115570 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2018.03.008 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29622372 ● Summary page in Scopus @ Elsevier: 2-s2.0-85049537109 (徳島大学機関リポジトリ: 115570, DOI: 10.1016/j.jstrokecerebrovasdis.2018.03.008, PubMed: 29622372, Elsevier: Scopus)
24.	高麗雅章, 溝渕佳史, 髙木康志, 永廣信治 : スポーツ頭部外傷の基礎知識, 作業療法ジャーナル, Vol.52, No.7, 646-650, 2018年. (出版サイトへのリンク) ● Publication site (DOI): 10.11477/mf.5001201344 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.11477/mf.5001201344 (DOI: 10.11477/mf.5001201344)
25.	高麗雅章, 里見淳一郎, 髙木康志 : 硬膜動静脈瘻に対する直達術, 脳神経外科速報, Vol.28, No.7, 678-683, 2018年.
26.	Yasuhisa Kanematsu, Junichiro Satomi, Masaaki Korai, Toshiyuki Okazaki, Idumi Yamaguchi, Yoshiteru Tada, Masaaki Uno, Shinji Nagahiro and Yasushi Takagi : Flow Alteration Therapy for Ruptured Vertebral Artery Dissecting Aneurysms Involving the Posterior Inferior Cerebellar Artery, Neurologia Medico-Chirurgica, Vol.58, 341-349, 2018. (要約) Surgery for- and endovascular treatment of vertebral artery (VA) dissecting aneurysms involving the origin of the posterior inferior cerebellar artery (PICA) remain challenging. Their ideal treatment is complete isolation of the aneurysm by surgical or endovascular trapping plus PICA reconstruction. However, postoperative lower cranial nerve palsy and medullary infarction are potential complications. We report four patients with VA dissecting aneurysms involving the PICA origin who were treated by occipital artery (OA)-PICA bypass followed by proximal occlusion of the VA and clip ligation of the PICA origin instead of trapping. There were no procedural or ischemic complications. In all patients, angiography performed 2-3 weeks later showed good patency of the bypass graft and complete obliteration of the aneurysm. During the follow-up period ranging from 1 to 14 years, none experienced bleeding. Although retrograde blood flow to the dissecting aneurysm persisted in the absence of trapping, iatrogenic lower cranial nerve injury could be avoided. The decrease in aneurysmal flow might elicit spontaneous thrombosis and prevent aneurysmal rerupture. Our technique might be less invasive than aneurysmal trapping and help to prevent rebleeding. (徳島大学機関リポジトリ) ● Metadata: 119189 (出版サイトへのリンク) ● Publication site (DOI): 10.2176/nmc.oa.2018-0076 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29998934 ● Summary page in Scopus @ Elsevier: 2-s2.0-85051865821 (徳島大学機関リポジトリ: 119189, DOI: 10.2176/nmc.oa.2018-0076, PubMed: 29998934, Elsevier: Scopus)
27.	Yuki Yamamoto, Nobuaki Yamamoto, Junichiro Satomi, Idumi Yamaguchi, Masaaki Korai, Yasuhisa Kanematsu, Yasushi Takagi and Ryuji Kaji : Dural arteriovenous fistula in the superior orbital fissure, Surgical Neurology International, Vol.9, No.1, 95, 2018. (要約) Dural arteriovenous fistulas (dAVFs) are extremely rare in the superior orbital fissure, and they exhibit ocular symptoms similar to the dAVF in the cavernous sinus because of the intraorbital venous congestion. Hence, the distinction of these conditions is imperative because of some inherent differences in endovascular treatment techniques. A 58-year-old woman presented with a gradually worsening left eyeball protrusion and conjunctival congestion. The digital subtraction angiography revealed a dAVF with a shunting point in the left superior orbital fissure. Moreover, the inferolateral trunk of the left internal carotid artery and the left middle meningeal artery were involved as feeding arteries. Shunting blood flow drained into the facial vein through the superior ophthalmic vein (SOV) but not into the cavernous sinus, which was located just posterior to the superior orbital fissure. We performed transvenous coil embolization in the SOV through the facial vein, and the symptoms disappeared completely. We experienced a case of a dAVF in the superior orbital fissure. This case presented a possibility of the presence of one subtype of the dAVF in the part of the cavernous sinus separated at the superior orbital fissure in front. Transvenous coil embolization in the SOV through the facial vein efficiently occluded the fistula. (出版サイトへのリンク) ● Publication site (DOI): 10.4103/sni.sni_46_18 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29888029 ● Search Scopus @ Elsevier (PMID): 29888029 ● Search Scopus @ Elsevier (DOI): 10.4103/sni.sni_46_18 (DOI: 10.4103/sni.sni_46_18, PubMed: 29888029)
28.	Hidetsugu Maekawa, Yoshiteru Tada, Kenji Yagi, Takeshi Miyamoto, Kitazato T. Keiko, Masaaki Korai, Junichiro Satomi, Tomoki Hashimoto and Shinji Nagahiro : Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats., Journal of Neuroinflammation, Vol.2, No.14, 197, 2017. (要約) Estrogen deficiency is thought to be responsible for the higher frequency of aneurysmal subarachnoid hemorrhage in post- than premenopausal women. Estrogen replacement therapy appears to reduce this risk but is associated with significant side effects. We tested our hypothesis that bazedoxifene, a clinically used selective estrogen receptor (ER) modulator with fewer estrogenic side effects, reduces cerebral aneurysm rupture in a new model of ovariectomized rats. Ten-week-old female Sprague-Dawley rats were subjected to ovariectomy, hemodynamic changes, and hypertension to induce aneurysms (ovariectomized aneurysm rats) and treated with vehicle or with 0.3 or 1.0 mg/kg/day bazedoxifene. They were compared with sham-ovariectomized rats subjected to hypertension and hemodynamic changes (HT rats). The vasoprotective effects of bazedoxifene and the mechanisms underlying its efficacy were analyzed. During 12 weeks of observation, the incidence of aneurysm rupture was 52% in ovariectomized rats. With no effect on the blood pressure, treatment with 0.3 or 1.0 mg/kg/day bazedoxifene lowered this rate to 11 and 17%, almost the same as in HT rats (17%). In ovariectomized rats, the mRNA level of ERα, ERβ, and the tissue inhibitor of metalloproteinase-2 was downregulated in the cerebral artery prone to rupture at 5 weeks after aneurysm induction; the mRNA level of interleukin-1β and the matrix metalloproteinase-9 was upregulated. In HT rats, bazedoxifene restored the mRNA level of ERα and ERβ and decreased the level of interleukin-1β and matrix metalloproteinase-9. These findings suggest that bazedoxifene was protective against aneurysmal rupture by alleviating the vascular inflammation and degradation exacerbated by the decrease in ERα and ERβ. Our observation that bazedoxifene decreased the incidence of aneurysmal rupture in ovariectomized rats warrants further studies to validate this response in humans. (キーワード) Animals / 血圧 (blood pressure) / Cerebral Arteries / Cytokines / Disease Models, Animal / Dose-Response Relationship, Drug / Estrogen Receptor alpha / Estrogen Receptor beta / Female / Gene Expression Regulation / 高血圧 (hypertension) / Indoles / Intracranial Aneurysm / Matrix Metalloproteinase 2 / Ovariectomy / RNA, Messenger / Rats / Rats, Sprague-Dawley / Salts / Selective Estrogen Receptor Modulators / Tissue Inhibitor of Metalloproteinase-2 (徳島大学機関リポジトリ) ● Metadata: 111431 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12974-017-0966-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28969701 ● Summary page in Scopus @ Elsevier: 2-s2.0-85030714321 (徳島大学機関リポジトリ: 111431, DOI: 10.1186/s12974-017-0966-7, PubMed: 28969701, Elsevier: Scopus)
29.	Masaaki Korai, 北里慶子, Yoshiteru Tada, Takeshi Miyamoto, Kenji Shimada, Nobuhisa Matsushita, Yasuhisa Kanematsu, Junichiro Satomi, 橋本友紀 and Shinji Nagahiro : Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats, Journal of Neuroinflammation, Vol.13, No.1, 165, 2016. (要約) Hyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall. However, the role of HHcy in the growth and rupture of cerebral aneurysms remains unclear. Thirteen-week-old female Sprague-Dawley rats were subject to bilateral ovariectomy and ligation of the right common carotid artery and fed an 8 % high-salt diet to induce cerebral aneurysms. Two weeks later, they underwent ligation of the bilateral posterior renal arteries. They were divided into two groups and methionine (MET) was or was not added to their drinking water. In another set of experiments, the role of folic acid (FA) against cerebral aneurysms was assessed. During a 12-week observation period, subarachnoid hemorrhage due to aneurysm rupture was observed at the anterior communicating artery (AcomA) or the posterior half of the circle of Willis. HHcy induced by excessive MET intake significantly increased the incidence of ruptured aneurysms at 6-8 weeks. At the AcomA of rats treated with MET, we observed the promotion of aneurysmal growth and infiltration by M1 macrophages. Furthermore, the mRNA level of MMP-9, the ratio of MMP-9 to the tissue inhibitor of metalloproteinase-2, and the level of interleukin-6 were higher in these rats. Treatment with FA abolished the effect of MET, suggesting that the inflammatory response and vascular degradation at the AcomA is attributable to HHcy due to excessive MET intake. We first demonstrate that in hypertensive ovariectomized rats, HHcy induced by excessive MET intake may be associated with the propensity of the aneurysm wall to rupture. (徳島大学機関リポジトリ) ● Metadata: 110031 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12974-016-0634-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27349749 ● Search Scopus @ Elsevier (PMID): 27349749 ● Search Scopus @ Elsevier (DOI): 10.1186/s12974-016-0634-3 (徳島大学機関リポジトリ: 110031, DOI: 10.1186/s12974-016-0634-3, PubMed: 27349749)
30.	Takeshi Miyamoto, DK Kung, KT Kitazato, Kenji Yagi, Kenji Shimada, Yoshiteru Tada, Masaaki Korai, Yoshitaka Kurashiki, Tomoya Kinouchi, Yasuhisa Kanematsu, Junichiro Satomi, T Hashimoto and Shinji Nagahiro : Site-specific elevation of interleukin-1β and matrix metalloproteinase-9 in the Willis circle by hemodynamic changes is associated with rupture in a novel rat cerebral aneurysm model, Journal of Cerebral Blood Flow and Metabolism, Vol.37, No.8, 2795-2805, 2016. (要約) The pathogenesis of subarachnoid hemorrhage remains unclear. No models of cerebral aneurysms elicited solely by surgical procedures and diet have been established. Elsewhere we reported that only few rats in our original rat aneurysm model manifested rupture at the anterior and posterior Willis circle and that many harbored unruptured aneurysms at the anterior cerebral artery-olfactory artery bifurcation. This suggests that rupture was site-specific. To test our hypothesis that a site-specific response to hemodynamic changes is associated with aneurysmal rupture, we modified our original aneurysm model by altering the hemodynamics. During 90-day observation, the incidence of ruptured aneurysms at the anterior and posterior Willis circle was significantly increased and the high incidence of unruptured aneurysms at the anterior cerebral artery-olfactory artery persisted. This phenomenon was associated with an increase in the blood flow volume. Notably, the level of matrix metalloproteinase-9 associated with interleukin-1β was augmented by the increase in the blood flow volume, suggesting that these molecules exacerbated the vulnerability of the aneurysmal wall. The current study first demonstrates that a site-specific increase in interleukin-1β and matrix metalloproteinase-9 elicited by hemodynamic changes is associated with rupture. Our novel rat model of rupture may help to develop pharmaceutical approaches to prevent rupture. (徳島大学機関リポジトリ) ● Metadata: 110032 (出版サイトへのリンク) ● Publication site (DOI): 10.1177/0271678X16675369 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27798272 ● Search Scopus @ Elsevier (PMID): 27798272 ● Search Scopus @ Elsevier (DOI): 10.1177/0271678X16675369 (徳島大学機関リポジトリ: 110032, DOI: 10.1177/0271678X16675369, PubMed: 27798272)
31.	Manabu Sumiyoshi, Junichiro Satomi, KT Kitazato, Kenji Yagi, Yoshitaka Kurashiki, Masaaki Korai, Takeshi Miyamoto, Kazuyuki Kuwayama and Shinji Nagahiro : PPAR-dependent- and -independent inhibition of the HMGB1/TLR9 Pathway by EPA attenuates ischemic brain damage in ovariectomized rats, Journal of Stroke & Cerebrovascular Diseases, Vol.24, No.6, 1187-1195, 2015. (要約) High mobility group box 1 (HMGB1) elevation after cerebral ischemia activates inflammatory pathways via receptors such as the receptor for advanced glycation end products (RAGE) and toll-like receptors (TLRs) and leads to brain damage. Eicosapentaenoic acid (EPA), a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, attenuates postischemic inflammation and brain damage in male animals. However, postischemic HMGB1 signaling and the effects of EPA on ovariectomized (OVX(+)) rats remain unclear. We hypothesized that EPA attenuates brain damage in OVX(+) rats via the inhibition of HMGB1 signaling in a PPARγ-dependent manner. Seven-week-old female Sprague-Dawley rats were divided into 3 groups; nonovariectomized (OVX(-)) rats and EPA-treated and EPA-untreated OVX(+) rats before cerebral ischemia induction. Another set of EPA-treated OVX(+) rats was injected with the PPARγ inhibitor GW9662. OVX(+) decreased the messenger RNA level of PPARγ and increased that of HMGB1, RAGE, TLR9, and tumor necrosis factor alpha (TNFα) in parallel with ischemic brain damage. EPA restored the PPARγ expression, downregulated the HMGB1 signal-related molecules, and attenuated the ischemic brain damage. Neither OVX(+) nor EPA affected the expression of TLR2 or TLR4. Interestingly, GW9662 partially abrogated the EPA-induced neuroprotection and the downregulation of RAGE and TLR9. In contrast, GW9662 did not affect HMGB1 or TNFα. These results suggest that EPA exerts PPARγ-dependent and PPARγ-independent effects on postischemic HMGB1/TLR9 pathway. The cortical infarct volume exacerbated by OVX(+) is associated with the upregulation of the HMGB1/TLR9 pathway. Suppression of this pathway may help to limit ischemic brain damage in postmenopausal women. (キーワード) Anilides / Animals / 脳 (brain) / Brain Ischemia / Eicosapentaenoic Acid / Female / HMGB1 Protein / Ovariectomy / PPAR gamma / Rats / Rats, Sprague-Dawley / 情報伝達 (signal transduction) / Toll-Like Receptor 9 / Up-Regulation (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2015.01.009 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25920754 ● Summary page in Scopus @ Elsevier: 2-s2.0-84930179213 (DOI: 10.1016/j.jstrokecerebrovasdis.2015.01.009, PubMed: 25920754, Elsevier: Scopus)
32.	高麗雅章, 瀧本理, 大林正明, 加島健司, 永廣信治 : 増大する器質化慢性硬膜下血腫の診断と治療:症例報告, 脳神経外科速報, Vol.20, No.6, 716-721, 2010年.

学術論文(紀要・その他):

1.	Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Nobuaki Yamamoto, Masaaki Korai, Kazuhisa Miyake, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, Yuki Yamamoto, Kazutaka KURODA and Yasushi Takagi : Evaluation of Serial Intra-Arterial Indocyanine Green Videoangiography in the Surgical Treatment of Cranial and Craniocervical Junction Arteriovenous Fistulae: A Case Series, Operative Neurosurgery, Vol.25, No.3, 292-300, 2023. (要約) Intravenous indocyanine green (IV-ICG) videoangiography is commonly performed to detect blood flow in the microscopic view. However, intra-arterial ICG (IA-ICG) videoangiography provides high-contrast imaging, repeatability within a short period of time, and clear-cut separation of the arterial and venous phases compared with IV-ICG. These features are useful for detecting retrograde venous drainage (RVD) and shunt occlusion in arteriovenous fistulae (AVF) surgery. This study aimed to investigate whether IA-ICG videoangiography can be repeatable within a short period of time and be useful for detecting RVD and shunt occlusion in cranial- and craniocervical junction (CCJ)-AVF surgery. Between January 2012 and December 2022, 50 patients were treated with endovascular or surgical intervention for cranial- and CCJ-AVF at Tokushima University Hospital. Of these, 5 patients (6 lesions) underwent open surgery with IA-ICG videoangiography in a hybrid operating room. We analyzed the data of these 5 patients (6 lesions). There were 4/patient (median, range 2-12) and 3.5/lesion (median, range 2-10) intraoperative IA-ICG runs. IA-ICG videoangiography detected RVD in all patients. Clearance of IA-ICG-induced fluorescence was achieved within 30 seconds in all patients at each region of interest. After the disconnection of the fistulae, IA-ICG videoangiography and intraoperative digital subtraction angiography (DSA) confirmed the disappearance of RVD in all patients. There were no complications associated with IA-ICG videoangiography. This study showed that IA-ICG videoangiography is repeatable within a short period of time before and after obliteration and can be useful for detecting RVD and shunt occlusion in cranial- and CCJ-AVF surgery. IA-ICG videoangiography also allows intraoperative DSA studies in a hybrid operating room. Considering the recent advancements in hybrid operating rooms, combining IA-ICG videoangiography with intraoperative DSA is a useful strategy for cranial- and CCJ-AVF surgery. (キーワード) Humans / Indocyanine Green / Coloring Agents / Neurosurgical Procedures / Vascular Surgical Procedures / Arteries (出版サイトへのリンク) ● Publication site (DOI): 10.1227/ons.0000000000000796 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37345942 ● Summary page in Scopus @ Elsevier: 2-s2.0-85168222953 (DOI: 10.1227/ons.0000000000000796, PubMed: 37345942, Elsevier: Scopus)

総説・解説:

1.	高麗雅章, 多田恵曜, 北里慶子, 橋本友紀, 髙木康志 : 脳動脈瘤の発生のメカニズム, Clinical Neuroscience, Vol.41, No.10, 1332-1335, 2023年10月. (キーワード) 脳動脈瘤 (brain aneurysm) / くも膜下出血
2.	高麗雅章, 里見淳一郎 : 脳梗塞超急性期診療で求められる対応体制, 日獨医報, Vol.62, No.2, 66-70, 2018年1月.
3.	高麗雅章, 里見淳一郎 : 【新人ナース応援号日本一カンタン・わかりやすい脳神経外科疾患ノート】未破裂脳動脈瘤, Brain Nursing, Vol.33, No.4, 316-317, 2017年4月.

国際会議:

1.	Tadashi Yamaguchi, Keiko T Kitazato, Eiji Shikata, Idumi Yamaguchi, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yoshiteru Tada, Yasuhisa Kanematsu and Yasushi Takagi : Pro-inflammatory response promoted by Porphyromonas gingivalis lipopolysaccharide enhances the rupture of experimental intracranial aneurysms., Brain and Brain PET2019, Yokohama, Jul. 2019.
2.	Yuki Yamamoto, Nobuaki Yamamoto, K Kuroda, Yasuhisa Kanematsu, Masaaki Korai, Kenji Shimada, Yuishin Izumi and Yasushi Takagi : High White Blood Cell Count is a Risk Factor for Contrast-Induced Nephropathy following Mechanical Thrombectomy, The 5th European Stroke Organization Conference, ESOC 2019, Milan, May 2019.
3.	Nobuaki Yamamoto, Yuki Yamamoto, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yuishin Izumi, Yasushi Takagi and Ryuji Kaji : Hyperintense Signals on Arterial Spin-Labeled Imaging as a predictor for favorable outcome after Late Time Window Thrombectomy, The 5th European Stroke Organization Conference, ESOC 2019, Milan, May 2019.
4.	山口泉, 四方英二, 高麗雅章, 兼松康久, 里見淳一郎, 北里慶子, 永廣信治, 髙木康志 : Retrospective study of patients with in-hospital stroke, 11th World Stroke Congress 2018, モントリオール, 2018年10月.
5.	Tadashi Yamaguchi, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yoshiteru Tada, Yasuhisa Kanematsu, Junichiro Satomi, Shinji Nagahiro and Yasushi Takagi : Estrogen deficiency activates inflammasome in a rat model of intracranial aneurysms, 11th World Stroke Congress 2018, Montreal, Oct. 2018.
6.	Masaaki Korai, Yasuhisa Kanematsu, Idumi Yamaguchi, Nobuaki Yamamoto, Yuki Yamamoto, Junichiro Satomi and Yasushi Takagi : Treatment strategy and outcom of ruptured vertebral artry dissecting aneurysms, World Live Neurovascular Conference 2018, 神戸市, Apr. 2018.
7.	Yuki Yamamoto, Nobuaki Yamamoto, Idumi Yamaguchi, Masaaki Korai, Yasuhisa Kanematsu, Junichiro Satomi, Shinji Nagahiro and Ryuji Kaji : Crab claw sign predicts successful recanalization in acute mechanical thrombectomy, 14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY, Budapest, Oct. 2017.
8.	Masaaki Korai, Yasuhisa Kanematsu, Yoshiteru Tada, Idumi Yamaguchi, Nobuaki Yamamoto, Yuki Yamamoto and Junichiro Satomi : Treatment strategy and outcome of ruptured vertebral artery dissecting aneurysms, 14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY, Budapest, Oct. 2017.
9.	Junichiro Satomi, Yasuhisa Kanematsu, Masaaki Korai, Yuki Yamamoto, Nobuaki Yamamoto, Yoshifumi Mizobuchi, Hideo Mure, Yoshiteru Tada, Kohhei Nakajima, Toshiyuki Okazaki and Toshitaka Fujihara : Acute stroke management using image sharing on smart phones and tablet devices, 14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY, Budapest, Oct. 2017.
10.	Masaaki Korai, H Furukawa, Y Kamio, K Mitsui, Shinji Nagahiro and T Hashimoto : Roles of Neutrophil Extracellular Trap in the Rupture of Intracranial Aneurysm, International Stroke Conference 2017, Houston, Feb. 2017.
11.	Takeshi Miyamoto, Yoshiteru Tada, Kenji Shimada, Kenji Yagi, Masaaki Korai, Hidetsugu Maekawa, Tadashi Yamaguchi, Syotaro Soshioka, Tomoya Kinouchi, Yasuhisa Kanematsu, Junichiro Satomi and Shinji Nagahiro : Pro-inflammatory Response Elicited by Porphyromonas Gingivalis Lipopolysaccharide Exacerbates the Rupture of Experimental Cerebral Aneurysms, International Stroke Conference 2017, Houston, Feb. 2017.
12.	Junichiro Satomi, Yoshiteru Tada, Yasuhisa Kanematsu, Kazuyuki Kuwayama, Kenji Yagi, Tomoya Kinouchi, Kohhei Nakajima, Nobuhisa Matsushita, Takeshi Miyamoto, Tadashi Yamaguchi, Masaaki Korai, Hideo Mure, Keiko Kitazato and Shinji Nagahiro : A Pilot Study of the Mineralocorticoid Receptor Blocker Eplerenone in Hypertensive Patients with Unruptured Cerebral Aneurysms, International Stroke Conference 2016, Los Angeles, Feb. 2016.
13.	Takeshi Miyamoto, Masaaki Korai, David K. Kung, Keiko K. Kitazato, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Yoshitaka Kurashiki, Kazuyuki Kuwayama, Junichiro Satomi and Shinji Nagahiro : Hemodynamic changes elicit the formation and rupture of experimental cerebral aneurysms, International stroke conference, Nashville, Feb. 2015.
14.	Masaaki Korai, Kenji Shimada and Tomoki Hashimoto : Roles of macrophage PPARγ on intracranial aneurysmal rupture, International stroke conference, Nashville, Feb. 2015.
15.	Masaaki Korai, Kenji Yagi, Keiko T. Kitazato, Yoshiteru Tada, Junichiro Satomi and Shinji Nagahiro : Hyperhomocysteinemia is associated with vulnerability of the cerebral aneurysmal wall to rupture in ovariectomized rats., International stroke conference, Nashville, Feb. 2015.
16.	Masaaki Korai, Kenji Shimada, Yoshiteru Tada and Shinji Nagahiro : INTERNATIONAL STROKE CONFERENCE 2015 Roles of Macrophage PPAR on Intracranial Aneurysmal Rupture, INTERNATIONAL STROKE CONFERENCE 2015, Feb. 2015.
17.	宮本健志, Masaaki Korai, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Yoshitaka Kurashiki, Kazuyuki Kuwayama, Junichiro Satomi and Shinji Nagahiro : Hemodynamic Changes May Be Partly Attributable To The Formation And Rupture Of Aneurysms In A Rat Model, INTERNATIONAL STROKE CONFERENCE 2015, Feb. 2015.
18.	Masaaki Korai, David K Kung, K.T Kitazato, Nobuhisa Matsushita, Yoshiteru Tada, Kenji Yagi, Kenji Shimada, Yasuhisa Kanematsu, Junichiro Satomi and Shinji Nagahiro : Role of hyperhomocysteinemia in the development of intracranial aneurysms, Congress Of Neurological Surgeons 2013 Annual Meeting, San Francisco, Oct. 2013.
19.	Masaaki Korai, DK Kung, KT Kitazato, Nobuhisa Matsushita, Yoshiteru Tada, Kenji Yagi, Yasuhisa Kanematsu, Junichiro Satomi and Shinji Nagahiro : Imbalance between activation of matrix metalloprotease and its inhibition may facilitate the growth of cerebral aneurysm in female rats, International Stroke Conference 2013, Honolulu, Feb. 2013.
20.	Yasuhisa Kanematsu, Masaaki Korai, N Yamamoto, Junichiro Satomi and Shinji Nagahiro : Vascular reconstruction for internal carotid artery stenosis with contralateral carotid occlusion or severe stenosis - single-center experience -, 10th Meeting of Asian Australasian Federation of Interventional and Therapeutic Neuroradiology, Nagoya, Jun. 2012.
21.	Masaaki Korai, Junichiro Satomi, N Yamamoto, Yasuhisa Kanematsu and Shinji Nagahiro : The significance of endovascular therapy in vertebral artery dissecting aneurysm, 10th Meeting of Asian Australasian Federation of International and Therapeutic Neuroradiology, Nagoya, Jun. 2012.
22.	Yasuhisa Kanematsu, Masaaki Korai, Nobuaki Yamamoto, Junichiro Satomi and Shinji Nagahiro : Vascular Reconstruction for Internal Carotid Artery Stenosis with Contralateral Carotid Occlusion or severe stenosis - Single-Center Experience -, 10th Meeting of Asian Australasian Federation of Interventional and Therapeutic Neuroradiology, Nagoya, Jun. 2012.
23.	Masaaki Korai, Keiko T. Kitazato, Tomoya Kinouchi, Kenji Shimada, Nobuhisa Matsushita, Manabu Sumiyoshi, Yasuhisa Kanematsu, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro : Activation of Nuclear Receptors on Neuroprotection after Experimental Cerebral Ischemia in Female Rats, American Association of Neurologial Surgeons Annual Scientific Meeting, Miami, Apr. 2012.

国内講演発表:

1.	高麗雅章, 宮本健志, 石原学, 島田健司, 髙木康志 : 破裂動脈瘤に対してコイル塞栓術を施行し再治療を要した症例の特徴, 日本脳神経外科学会第83回学術総会, 2024年10月.
2.	宮本健志, 石原学, 高麗雅章, 島田健司, 髙木康志 : もやもや病に対する血行再建術後におけるArterial spin-labelingの変化, 日本脳神経外科学会第83回学術総会, 2024年10月.
3.	多田恵曜, 藤原敏孝, 高麗雅章, 宮本健志, 島田健司, 髙木康志 : くも膜下出血急性期における非けいれん性てんかん重積状態の転帰, 日本脳神経外科学会第83回学術総会, 2024年10月.
4.	富永洋介, 高麗雅章, 宮本健志, 山本雄貴, 山本伸昭, 島田健司, 髙木康志 : 脳梗塞で発症した大型部分血栓化後大脳動脈瘤の一例, 第33回NPO法人日本脳神経血管内治療学会中国四国地方会, 2024年9月.
5.	高麗雅章 : 高齢者(80歳以上)くも膜下出血に対する脳動脈瘤コイル塞栓術の治療成績の検討, 第37回日本老年脳神経外科学会, 2024年4月.
6.	佐原和真, 島田健司, 羽星辰哉, 山口泉, 曽我部周, 高麗雅章, 山本伸昭, 兼松康久, 髙木康志 : 脳梗塞の塞栓源と考えられた頚部外頸動脈瘤の一例, 第97回日本脳神経外科学会中国四国支部会, 2024年4月.
7.	兼松康久, 金澤裕樹, 島田健司, 高麗雅章, 曽我部周, 石原学, 山口泉, 羽星辰哉, 山本伸昭, 黒田一駿, 原田雅史, 髙木康志 : CEST MRIを用いた頚動脈プラーク診断, STROKE 2024, 2024年3月.
8.	島田健司, 山口泉, 宮本健志, 曽我部周, 高麗雅章, 山本伸昭, 花岡真実, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 : 骨内シャントの有無による海綿静脈洞部硬膜動静脈瘻の臨床的特徴の違いについて, STROKE 2024, 2024年3月.
9.	高麗雅章, 榎本紀哉, 羽星辰哉, 山口泉, 曽我部周, 島田健司, 黒田一駿, 山本伸昭, 兼松康久, 松原俊二, 佐藤浩一, 髙木康志 : 円蓋部硬膜動静脈瘻の発生と流出静脈路の経時的な変化についての考察, STROKE 2024, 2024年3月.
10.	高麗雅章, 榎本紀哉, 山口泉, 曽我部周, 島田健司, 黒田一駿, 山本伸昭, 兼松康久, 松原俊二, 佐藤浩一, 髙木康志 : 円蓋部硬膜動静脈瘻の発生と流出静脈路の経時的な変化についての考察, 第39回日本脳神経血管内治療学会学術集会, 2023年11月.
11.	島田健司, 山口泉, 宮本健志, 曽我部周, 高麗雅章, 山本伸昭, 花岡真美, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 : 骨内シャントの有無による海綿静脈洞部硬膜動静脈瘻の臨床的特徴の違いについて, 第39回日本脳神経血管内治療学会学術集会, 2023年11月.
12.	兼松康久, 羽星辰哉, 山口泉, 石原学, 曽我部周, 高麗雅章, 島田健司, 黒田一駿, 山本伸昭, 髙木康志 : 地方におけるICTを活用した急性期脳卒中診療の取り組み, 第39回日本脳神経血管内治療学会学術集会, 2023年11月.
13.	兼松康久, 羽星辰哉, 山口泉, 石原学, 曽我部周, 高麗雅章, 島田健司, 髙木康志 : 循環器病推進計画の中での地方におけるICTを活用した急性期脳卒中診療の取り組み, 2023年10月.
14.	島田健司, 山口泉, 宮本健志, 曽我部周, 高麗雅章, 山本伸昭, 花岡真実, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 : 骨内シャントの有無による海綿静脈洞部硬膜動静脈瘻の臨床的特徴の違いについて, 日本脳神経外科学会第82回学術集会, 2023年10月.
15.	山本伸昭, 黒田一駿, 山本雄貴, 和泉唯信, 曽我部周, 高麗雅章, 島田健司, 兼松康久, 髙木康志 : First pass TICI2B患者の追加治療における意義, 第64回日本神経学会学術大会, 2023年5月.
16.	高麗雅章, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 石原学, 山口泉, 山本雄貴, 黒田一駿, 髙木康志 : 当院での急性期脳底動脈閉塞に対する血管内治療成績, 第48回日本脳卒中学会学術集会, 2023年3月.
17.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本伸昭, 山本雄貴, 和泉唯信, 髙木康志 : 徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, STROKE2023, 2023年3月.
18.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 髙木康志 : 当院での低ASPECTS症例の拡散強調画像に対するRAPIDを用いた後方視的定量評価, 第48回日本脳卒中学会学術集会, 2023年3月.
19.	黒田一駿, 山本雄貴, 山本伸昭, 松田知大, 板東康司, 山口泉, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 広範囲シャントを伴った横静脈洞部硬膜動静脈瘻に対して血管内治療を行った1例, 第112回日本神経学会中国・四国地方会, 2022年12月.
20.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 和泉唯信, 髙木康志 : 当院の主幹動脈閉塞低ASPECT症例の拡散強調画像に対するRAPIDでの後方視的定量評価, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
21.	山本雄貴, 兼松康久, 山本伸昭, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志, 和泉唯信 : 地方都市における救急医療連携アプリケーションを用いたLVO診断スケールの活用, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
22.	高麗雅章, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 石原学, 山口泉, 山本雄貴, 黒田一駿, 髙木康志 : 当院での急性期脳底動脈閉塞に対する血管内治療成績, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
23.	高麗雅章, 橋本友紀, 宮本健志, 北里慶子, 四方英二, 山口真司, 島田健司, 多田恵曜, 兼松康久, 髙木康志 : Neutrophil extracellular trapsは脳動脈瘤破裂を促進する, 日本脳神経外科学会第81回学術総会, 2022年9月.
24.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 髙木康志 : 当院での主幹動脈閉塞-低ASPECT症例の拡散強調画像に対するRAPIDを用いた後方視的定量評価, 日本脳神経外科学会第81回学術総会, 2022年9月.
25.	兼松康久, 山口泉, 石原学, 曽我部周, 高麗雅章, 多田恵曜, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 佐藤健太, 島谷佳光, 亘雄也, 田村哲也, 新野清人, 髙木康志 : 徳島県総合メディカルゾーンでの急性期脳卒中診療の取り組み, 日本脳神経外科学会第81回学術総会, 2022年9月.
26.	山本雄貴, 兼松康久, 山本伸昭, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志, 和泉唯信 : 徳島市におけるアプリケーションを用いたLVO診断スケールの活用(FAST-ED Tokushima), 第24回中国四国脳卒中研究会, 2022年9月.
27.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, 徳島医学会学術集会, 2022年7月.
28.	高麗雅章, 佐藤浩一, 山口真司, 花岡真実, 仁木均, 松﨑和仁 : 円蓋部硬膜動静脈瘻に対する経動脈的塞栓術, 第24回徳島脳血管障害カンファレンス, 2022年3月.
29.	山本陽子, 兼松康久, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 髙木康志 : Neckからfetal typeのPcomが起始する大型血栓化IC-PC動脈瘤に対しステント併用下コイル塞栓術を行った一例, 第88回(一社)日本脳神経外科学会中国四国支部学術集会, 2019年12月.
30.	山口真司, 宮本健志, 北里慶子, 四方英二, 山口泉, 高麗雅章, 島田健司, 多田恵曜, 兼松康久, 髙木康志 : エストロゲン欠乏脳動脈瘤ラットモデルにおけるERαの低下とNLRP3 inflammasome活性の関係, 第62回日本脳循環代謝学会学術集会, 2019年11月.
31.	山本雄貴, 山本伸昭, 兼松康久, 石原学, 宮本健志, 高麗雅章, 島田健司, 牟礼英生, 髙木康志, 和泉唯信 : 転倒後の脳脊髄液減少症に上矢状静脈洞血栓症を合併し, 血管内治療をおこなった一例, 第35回日本脳神経血管内治療学会学術総会, 2019年11月.
32.	島田健司, 佐藤浩一, 松田拓, 宮本健志, 高麗雅章, 兼松康久, 髙木康志 : Targeting‌embolizationを行わず，流出路をコイル塞栓することにより舌下神経障害なく治療し得た‌ACC‌dAVFの1例, 第35回日本脳神経血管内治療学会学術総会, 2019年11月.
33.	兼松康久, 島田健司, 高麗雅章, 宮本健志, 多田恵曜, 山本雄貴, 山本伸昭, 里見淳一郎, 髙木康志 : 当院での急性期脳底動脈閉塞に対する血管内治療成績, 第35回日本脳神経血管内治療学会学術総会, 2019年11月.
34.	松田拓, 島田健司, 宮本健志, 阿部考志, 高麗雅章, 兼松康久, 髙木康志 : T1-CUBEが有効であった頭蓋内動脈解離の2例, 日本脳神経外科学会第78回学術集会, 2019年10月.
35.	石原学, 兼松康久, 山本伸昭, 宮本健志, 高麗雅章, 島田健司, 山本雄貴, 大藤純, 髙木康志 : NIHSS 5点以下の軽症脳主幹動脈閉塞症例における予後因子, 日本脳神経外科学会第78回学術集会, 2019年10月.
36.	山口真司, 宮本健志, 北里慶子, 四方英二, 山口泉, 高麗雅章, 島田健司, 多田恵曜, 兼松康久, 髙木康志 : 脳動脈瘤破裂モデルにおける部位特異的な早期形態変化と血管崩壊関連分子の変動, 日本脳神経外科学会第78回学術集会, 2019年10月.
37.	兼松康久, 島田健司, 高麗雅章, 宮本健志, 山口泉, 山口真司, 多田恵曜, 里見淳一郎, 永廣信治, 髙木康志 : 当院における急性期脳底動脈閉塞に対する治療成績, 日本脳神経外科学会第78回学術集会, 2019年10月.
38.	宮本健志, 北里慶子, 多田恵曜, 島田健司, 高麗雅章, 山口真司, 兼松康久, 髙木康志 : Porphyromonas gingivalis LPSは脳動脈瘤モデルラットにおいて脳動脈瘤破裂を促進する, 日本脳神経外科学会第78回学術集会, 2019年10月.
39.	山口泉, 兼松康久, 島田健司, 高麗雅章, 宮本健志, 北里慶子, 山本伸昭, 山本雄貴, 髙木康志 : 院内発症脳梗塞の転帰不良に関連する因子の検討, Neurologia Medico-Chirurgica, 2019年10月.
40.	山本伸昭, 黒田一駿, 山本雄貴, 石原学, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : Tandem Occlusion患者に対する血管内治療(Simultaneous Approach), 第44回日本脳卒中学会学術集会, 2019年3月.
41.	山本雄貴, 山本伸昭, 黒田一駿, 高麗雅章, 岡﨑敏之, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 血栓回収療法後の造影剤腎症は白血球数高値と関連する, 第44回日本脳卒中学会学術集会, 2019年3月.
42.	西京子, 兼松康久, 高麗雅章, 岡﨑敏之, 島田健司, 山本伸昭, 高野栄之, 加藤真介, 髙木康志 : 徳島大学病院脳卒中センター (SCU)の多職種連携による医療人育成, 日本脳卒中学会2019, 2019年3月.
43.	山本雄貴, 山本伸昭, 黒田一駿, 福本竜也, 石原学, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 治療後に症状増悪した上矢状静脈洞血栓症の一例, 第8回脳血管内治療四国遍路塾, 2019年3月.
44.	山本雄貴, 黒田一駿, 山本伸昭, 鹿草宏, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 頭癌治療中に内頚動脈閉塞を認めた1例, 第21回徳島脳血管障害カンファレンス, 2019年3月.
45.	山本雄貴, 山本伸昭, 黒田一駿, 高麗雅章, 岡﨑敏之, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 塞栓回収療法後の造影剤腎症についての検討, 第21回徳島脳卒中研究会, 2019年2月.
46.	高麗雅章, 里見淳一郎, 山本雄貴, 山本伸昭, 岡﨑敏之, 島田健司, 兼松康久, 髙木康志 : Borden type 1横・S状静脈洞部硬膜動静脈瘻に対するバルーン支援下選択的経静脈塞栓術, 第34回日本脳神経血管内治療学会学術総会, 2018年11月.
47.	高麗雅章, 里見淳一郎, 山本雄貴, 山口泉, 山本伸昭 : Borden type 1 横・S状静脈胴部硬膜動静脈瘻に対するバルーン支援下選択的経静脈塞栓術, 第34回日本脳神経血管内治療学会学術総会, 2018年11月.
48.	高麗雅章, 里見淳一郎, 兼松康久, 牟礼英生, 島田健司, 岡﨑敏之, 髙木康志 : 硬膜動静脈瘻に対する直達術, 日本脳神経外科学会第77回学術総会, 2018年10月.
49.	兼松康久, 島田健司, 高麗雅章, 岡﨑敏之, 多田恵曜, 里見淳一郎, 永廣信治, 髙木康志 : 当院における高齢者(80歳以上)くも膜下出血の治療成績と予後の検討, 日本脳神経外科学会第77回学術総会, 2018年10月.
50.	岡﨑敏之, 兼松康久, 島田健司, 高麗雅章, 里見淳一郎, 宇野昌明, 髙木康志 : 当院におけるhemashield patchを使用した頸動脈内膜剥離術の長期成績の検討, 日本脳神経外科学会第77回学術総会, 2018年10月.
51.	高麗雅章, 羽星辰哉, 山本雄貴, 山本伸昭, 岡﨑敏之, 島田健司, 兼松康久, 髙木康志 : 脳腫瘍との鑑別を要した海綿静脈胴部硬膜動静脈瘻の一例, 脳血管内治療ブラッシュアップセミナー2018, 2018年9月.
52.	羽星辰哉, 高麗雅章, 牟礼英生, 兼松康久, 里見淳一郎, 髙木康志 : 頭蓋内出血で発症した蝶形骨小翼部硬膜動静脈瘻の1例, 第85回日本脳神経外科学会中国四国支部学術集会, 2018年4月.
53.	高麗雅章, 山口泉, 多田恵曜, 兼松康久, 里見淳一郎, 山本伸昭, 山本雄貴, 髙木康志 : 地方国立大学病院における院内発症脳卒中症例の特徴, 第43回日本脳卒中学会学術集会, 2018年3月.
54.	高麗雅章, 里見淳一郎, 山口泉, 兼松康久, 山本伸昭, 山本雄貴, 髙木康志 : 病型別にみた急性期脳主幹動脈閉塞に対する再開通療法, 第47回日本脳卒中の外科学会学術集会, 2018年3月.
55.	兼松康久, 高麗雅章, 宇野昌明, 永廣信治, 髙木康志 : PICA involved type の破裂椎骨動脈解離に対し，解離部の盲端化を行った4症例の検討, 第47回日本脳卒中の外科学会学術集会, 2018年3月.
56.	高麗雅章, 山本雄貴, 山口泉, 山本伸昭, 兼松康久, 髙木康志 : 当院の急性期主幹動脈閉塞に対する再開通療法の治療成績 -病型分類別にみた特徴-, 第33回NPO法人日本脳神経血管内治療学会学術総会, 2017年11月.
57.	高麗雅章, 里見淳一郎, 木内智也, 山本雄貴, 山口泉, 山本伸昭, 兼松康久, 髙木康志 : 病型別にみた急性期脳動脈閉塞に対する再開通療法の治療成績, 日本脳神経外科学会第76回学術総会, 2017年10月.
58.	高麗雅章, 木内智也, 多田恵曜, 兼松康久, 里見淳一郎, 永廣信治 : 当院における院内発症脳卒中症例の検討, 第4回日本心血管脳卒中学会学術集会, 2017年6月.
59.	高麗雅章, 橋本友紀, 北里慶子, 多田恵曜, 木内智也, 兼松康久, 里見淳一郎, 永廣信治 : 脳動脈瘤破裂におけるNeutrophil eztracellular tropの役割, 第42回日本脳卒中学会学術集会, 2017年3月.
60.	兼松康久, 里見淳一郎, 高麗雅章, 木内智也, 山口泉, 多田恵曜, 松原俊二, 佐藤浩一, 永廣信治 : くも膜下出血で発症した，解離性椎骨動脈瘤の治療方針と成績, 第46回日本脳卒中の外科学会学術集会, 2017年3月.
61.	宮本健志, 山口真司, K.Kung David, 北里慶子, 多田恵曜, 島田健司, 八木謙次, 高麗雅章, 兼松康久, 里見淳一郎, 永廣信治 : 新規脳動脈瘤破裂モデルにおける破裂動脈瘤の病態解明, 第59回日本脳循環代謝学会学術集会, 2016年11月.
62.	高麗雅章, 北里慶子, 多田恵曜, 宮本健志, 島田健司, 八木謙次, 松下展久, 兼松康久, 里見淳一郎, 永廣信治 : メチオニン過剰摂取による高ホモシステイン血症は崩壊しやすい特定脳動脈壁の炎症反応を増強し脳動脈瘤破裂を促進する, 第59回日本脳循環代謝学会学術集会, 2016年11月.
63.	多田恵曜, 兼松康久, 里見淳一郎, 桑山一行, 八木謙次, 木内智也, 中島公平, 高麗雅章, 牟礼英生, 宮本健志, 山口真司, 北里慶子, 永廣信治 : 高血圧症合併未破裂脳動脈瘤に対するミネラルコンチコイド受容体阻害薬の有効性に関するパイロット試験, 日本脳神経外科学会第75回学術総会, 2016年9月.
64.	宮本健志, 北里慶子, 高麗雅章, 八木謙次, 多田恵曜, 倉敷佳孝, 桑山一行, 里見淳一郎, 永廣信治 : ラットモデルにおける血行力学的変化と脳動脈瘤形成および破裂の関係, 第2回日本心血管脳卒中学会学術集会, 2015年6月.
65.	宮本健志, 高麗雅章, 北里慶子, 島田健司, 八木謙次, 多田恵曜, 倉敷佳孝, 里見淳一郎, 永廣信治, Kung K David : ラットモデルにおける血行力学的変化と脳動脈瘤形成および破裂の関係, 第26回日本脳循環代謝学会, 2014年11月.
66.	松下展久, 北里慶子, 多田恵曜, 住吉学, 高麗雅章, 兼松康久, 里見淳一郎, 永廣信治 : 体内水分貯留に対するナトリウム貯留の割合の増加は卵巣摘出ラットにおける脳動脈瘤形成と関係がある, 第38回日本脳卒中学会総会, 2013年3月.
67.	高麗雅章, 里見淳一郎, 山本伸昭, 松下展久, 多田恵曜, 兼松康久, 永廣信治 : 内頚動脈Carotid cave動脈瘤に対する血管内治療, 社団法人日本脳神経外科学会第71回学術総会, 2012年10月.
68.	萩野寛隆, 西山徹, 宮本健志, 高麗雅章, 兼松康久, 里見淳一郎, 永廣信治, 山本伸昭 : 妊娠中に発症した出血性脳卒中の二例, 第14回中国四国脳卒中研究会, 2012年9月.
69.	高麗雅章, 兼松康久, 永廣信治 : 脳死判定の実際と問題点, 第11回徳島臓器移植研究会, 2012年6月.
70.	兼松康久, 里見淳一郎, 高麗雅章, 山本伸昭, 溝渕佳史, 西京子, 永廣信治 : 反対側病変を伴う内頚動脈狭窄症に対する血行再建術, 第11回日本頸部脳血管治療学会, 2012年6月.
71.	兼松康久, 高麗雅章, 山本伸昭, 溝渕佳史, 里見淳一郎, 西京子, 永廣信治 : 対側閉塞または高度狭窄を伴う内頚動脈狭窄症に対する血行再建術, 第11回日本頸部脳血管治療学会, 2012年6月.
72.	高麗雅章, 里見淳一郎, 山本伸昭, 溝渕佳史, 兼松康久, 永廣信治 : 傍前床突起部内頸動脈瘤に対する血管内治療, 第37回日本脳卒中学会総会, 2012年4月.
73.	兼松康久, 高麗雅章, 溝渕佳史, 里見淳一郎, 永廣信治, 佐藤浩一, 松原俊二 : 再治療を要した脳動脈瘤コイル塞栓術症例の検討, 第37回日本脳卒中学会総会, 2012年4月.
74.	高麗雅章, 里見淳一郎, 山本伸昭, 牟礼英生, 兼松康久, 永廣信治 : VRDの先端がPcomに迷入した1例, 第43回近畿脳神経血管内手術法ワークショップ, 2012年1月.
75.	高麗雅章, 影治照喜, 溝渕佳史, 永廣信治, 古谷俊介, 喜多尚美, 西本利恵 : 重篤な意識障害を呈した膠芽腫の治療と看護, 徳島大学病院 Cancer Board, 2011年12月.
76.	高麗雅章, 山本伸昭, 兼松康久, 里見淳一郎, 溝渕佳史, 永廣信治, 佐藤浩一, 松原俊二 : 脳動脈瘤コイル塞栓術後，再治療を要した症例の検討, 第27回日本脳神経血管内治療学会学術総会, 2011年11月.
77.	高麗雅章, 平澤元浩, 永廣信治 : 脊髄硬膜動静脈瘻における術後ヘパリン化の必要性について, 第26回日本脊髄外科学会, 2011年6月.
78.	高麗雅章, 平澤元浩, 永廣信治 : 著名なspinal refluxを伴った頭蓋頚椎移行部硬膜動静脈瘻の1例, 第4回NeuroSpinalセミナー, 2011年2月.
79.	高麗雅章, 平澤元浩, 永廣信治 : 著名なspinal refluxを伴った頭蓋頚椎移行部硬膜動静脈瘻の1例, 第34回徳島脳神経外科談話会, 2010年12月.
80.	高麗雅章, 里見淳一郎, 兼松康久, 永廣信治, 佐藤浩一, 松原俊二 : 解離性椎骨動脈瘤における血管内治療の意義, 第26回日本脳神経血管内治療学会学術総会, 2010年11月.
81.	高麗雅章, 里見淳一郎, 兼松康久, 永廣信治, 佐藤浩一, 松原俊二 : 解離性椎骨動脈瘤の治療と長期成績, ㈳法人日本脳神経外科学会第69回学術総会, 2010年10月.
82.	谷口秀和, 高麗雅章, 西山徹, 里見淳一郎, 影治照喜, 永廣信治 : 頭蓋咽頭腫治療後22年目に発症した破裂前交通動脈瘤の1例, 第15回四国脳神経外科カンファレンス, 2010年8月.
83.	高麗雅章, 兼松康久, 里見淳一郎, 永廣信治 : 脳卒中急性期死亡例の検討, 第13回日本病院脳神経外科学会, 2010年7月.
84.	高麗雅章, 瀧本理, 大林正明 : 胃癌原発の硬膜転移による硬膜下水腫の1例, 第30回大分救急医学会・談話会, 2010年3月.
85.	高麗雅章, 瀧本理, 大林正明 : 開頭術を要した器質化慢性硬膜下血腫の1例, 第32回徳島脳神経外科談話会, 2009年12月.
86.	高麗雅章, 瀧本理, 大林正明, 加島健司 : 開頭術を要した器質化慢性硬膜下血腫の1例, 第103回日本脳神経外科学会九州支部会, 2009年10月.
87.	高麗雅章, 瀧本理, 大林正明 : 両側外傷性頭蓋内出血をきたし，両側開頭血栓除去術を行った1例, 釧徳SCカンファレンス'09, 2009年5月.
88.	高麗雅章, 瀧本理, 中田健, 法化図陽一, 岩永育貴 : 頭部MRIが有用であったWernicke脳症の1例, 第28回大分救急医学会・談話会, 2009年3月.
89.	高麗雅章, 瀧本理, 大林正明 : 大脳鎌硬膜動静脈瘻の1手術例, 第45回大分県脳卒中談話会, 2009年2月.
90.	Masaaki Korai, Osamu Takimoto and 大林正明 : 頭頂部硬膜動静脈瘻の一手術例, 第31回徳島脳神経外科懇談会, Dec. 2008.
91.	泉谷智彦, 高麗雅章, 鈴江淳彦, 河野威 : 下垂体腺腫に合併したtrue posterior communicating artery aneurysmの1例, 第30回NEUROSURGERYカンファレンスIN高知, 2008年9月.
92.	泉谷智彦, 高麗雅章, 鈴江淳彦, 河野威, 佐藤浩一 : 左鎖骨下動脈閉塞による鎖骨下動脈盗血現象により左三叉神経痛を生じ，左鎖骨下動脈のPTA(stenting)により三叉神経痛の寛解が得られた1例, 第8回高知県脳神経外科研究会, 2008年6月.
93.	高麗雅章, 鈴江淳彦, 泉谷智彦, 河野威 : 右片麻痺と失語症で発症した，左総頸動脈及び両側中大脳動脈の多発性閉塞を合併した1例, 第10回徳島脳血管障害カンファレンス, 2008年5月.
94.	泉谷智彦, 高麗雅章, 鈴江淳彦, 河野威 : モンロー孔部に発生したglioblastomaの1例, 第65回日本脳神経外科学会中国四国支部学術集会, 2008年3月.
95.	泉谷智彦, 高麗雅章, 鈴江淳彦, 河野威 : Cystic meningiomaの4例, 第28回NEUROSURGERYカンファレンスIN高知, 2008年2月.
96.	泉谷智彦, 高麗雅章, 鈴江淳彦, 河野威 : 脳室内腫瘍の1例, 第29回徳島脳神経外科談話会, 2007年12月.
97.	高麗雅章, 松原俊二, 花岡真実, 中嶌教夫, 永廣信治, 里見淳一郎, 佐藤浩一 : テント部硬膜動静脈瘻の臨床的検証, 第66回(社)日本脳神経外科学会総会, 2007年10月.
98.	高麗雅章, 松原俊二, 花岡真実, 中嶌教夫, 永廣信治, 里見淳一郎, 佐藤浩一 : 上錐体静脈洞部および頭蓋頚椎移行部に発生した多発性硬膜動静脈瘻の一例, 第16回中国四国脳神経血管内手術研究会, 2007年9月.

その他・研究会:

1.	鹿草 (名), 松田拓, 石原学, 高麗雅章, 岡﨑敏之, 島田健司, 兼松康久, 髙木康志 : くも膜下出血で発症した，前方循環系の動脈解離, 第44回徳島脳神経外科談話会, 2018年12月.
2.	高麗雅章 : 脳腫瘍との鑑別を要した海綿静脈洞部硬膜動静脈瘻の一例, 第56回近畿脳神経血管内手術法ワークショップ, 2018年7月.
3.	高麗雅章, 里見淳一郎, 山本雄貴, 山本伸昭, 兼松康久, 髙木康志 : 二期的に治療した海綿静脈胴部硬膜動静脈瘻の1例, 第7回脳血管内治療四国遍路塾, 2018年3月.
4.	高麗雅章, 里見淳一郎, 山本雄貴, 山口泉, 山本伸昭, 兼松康久, 髙木康志 : 頸動脈ステント留置術後10日目に過灌流による脳出血を来した1例, 第5回徳島脳疾患談話会, 2018年3月.
5.	鹿草宏, 兼松康久, 山本雄貴, 高麗雅章, 山本伸昭, 里見淳一郎, 髙木康志 : 急性期血行再建術後に腎不全をきたした1例, 第43回徳島脳神経外科談話会, 2017年12月.
6.	高麗雅章, 牟礼英生, 佐藤裕一, 兼松康久, 里見淳一郎, 髙木康志 : 蝶形頭頂静脈洞近傍にシャントを有し頭蓋内出血で発症した硬膜動静脈瘻の1例, 第43回徳島脳神経外科談話会, 2017年12月.
7.	山本雄貴, 山本伸昭, 和泉唯信, 山口泉, 高麗雅章, 木内智也, 兼松康久, 里見淳一郎, 永廣信治 : 頭蓋頚椎移行部 Perimedullary AVF の血管内治療例, 第19回徳島脳血管障害カンファレンス, 2017年5月.
8.	高麗雅章, 木内智也, 兼松康久, 山本雄貴, 山本伸昭, 里見淳一郎 : Blebの塞栓中に破裂した前交通動脈瘤の1例, 第53回近畿脳神経血管内治療法ワークショップ, 2017年1月.
9.	Masaaki Korai and Tomoki Hashimoto : Potential roles of neutrophil extracellular traps in stroke and trial for new SAH model., 3rd Conference on International Cooperative Research Network to Overcome Cerebrovascular Disease, Feb. 2015.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

脳血管障害に影響を及ぼす特定歯周病菌の同定とその制御法の検討 (研究課題/領域番号: 23K08500 )
脳動脈瘤破裂におけるinflammasome活性化とsirtuinの役割 (研究課題/領域番号: 20K09391 )
歯周病巣のexosomeによる脳動脈瘤破裂への影響 (研究課題/領域番号: 20K09326 )
Neutrophil extracellular trapsの脳血管障害への影響 (研究課題/領域番号: 18K16562 )
脳動脈瘤と歯周病に関する臨床および基礎的研究 (研究課題/領域番号: 17K10832 )
脳動脈瘤破裂予防を目指したinflammasomeに関する基礎的研究 (研究課題/領域番号: 17K10831 )
研究者番号（60794013）による検索

助教 : 高麗雅章

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

助教 : 高麗 雅章

研究活動

専門分野

研究テーマ

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

助教 : 高麗雅章