徳島大学 / 教育研究者総覧 --- 山本伸昭

専門分野

○	臨床神経
○	神経科学 (Neuroscience)

研究テーマ

○	急性期虚血性脳卒中
○	脳卒中患者データベースを利用した臨床研究

著書・論文

著書:

1.	鹿草宏, 溝渕佳史, 中島公平, 藤田浩司, 阿部考志, 影治照喜, 里見淳一郎, 永廣信治, 山本伸昭 : 眼科内腫瘍性病変, 2015年7月.
2.	武内俊明, 宮本亮介, 大崎裕亮, 阿部考志, 山本伸昭, 藤田浩司, 梶龍兒 : 中脳黒質におけるT1強調画像高信号, 株式会社メディカ出版, 大阪市淀川区宮原3-4-30, 2015年6月.
3.	山本伸昭, 宮城愛, 藤田浩司, 阿部考志, 里見淳一郎, 梶龍兒 : 亜急性に経過した基底核・脳幹部病変, 2015年5月.
4.	宮城愛, 山本伸昭, 藤田浩司, 阿部考志, 寺澤由佳, 梶龍兒 : 大脳半球に多発するT2*強調画像の点状低信号, 2015年2月.
5.	山本伸昭, 宮城愛, 藤田浩司, 阿部考志, 梶龍兒 : T1強調画像における基底核高信号, 2014年6月.

学術論文(審査論文):

1.	Shu Sogabe, HABOSHI Tatsuya, Izumi Yamaguchi, Masaaki Korai, Nobuaki Yamamoto, Kenji Shimada, Yasuhisa Kanematsu and Yasushi Takagi : Experience of using coronary perfusion balloon catheter for acute middle cerebral artery occlusion, Surgical Neurology International, Vol.14, No.365, 365, 2023. (要約) We present the case of an individual with acute occlusion of the middle cerebral artery caused by atherosclerosis. The patient underwent angioplasty using a coronary perfusion balloon, which resulted in a favorable clinical outcome. A 66-year-old male patient presented with an acute onset of right hemiplegia and dysarthria. Magnetic resonance imaging revealed an occlusion of the left middle cerebral artery, and alteplase was administered, followed by a mechanical thrombectomy and intracranial balloon catheter angioplasty. Due to restenosis, a coronary perfusion balloon catheter was used for a 15-minute angioplasty procedure while maintaining the perfusion. This treatment approach led to the recanalization of the artery and favorable clinical outcomes. The coronary perfusion balloon may represent a viable therapeutic alternative for the management of refractory intracranial atherosclerotic large vessel occlusion. (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_608_2023 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37941628 ● Search Scopus @ Elsevier (PMID): 37941628 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_608_2023 (DOI: 10.25259/SNI_608_2023, PubMed: 37941628)
2.	Yuki Yamamoto, Nobuaki Yamamoto, Tomohiro Matsuda, Kazutaka Kuroda, Izumi Yamaguchi, Shu Sogabe, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi and Yuishin Izumi : Stent retrieval for free-floating thrombus attached to carotid artery stenosis: A report of two cases., Surgical Neurology International, Vol.14, 274, 2023. (要約) In cases of carotid artery stenosis with FFT, it is technically possible to retrieve a thrombus with a stent retriever. Although thrombus removal may help reduce the risk of ischemic complications in a series of urgent CAS procedures, there are concerns such as mechanical irritation to the carotid artery plaque, and its indications and alternative treatments should be carefully considered. (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_513_2023 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37680937 ● Search Scopus @ Elsevier (PMID): 37680937 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_513_2023 (DOI: 10.25259/SNI_513_2023, PubMed: 37680937)
3.	Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi : Cranial geometry in patients with dystonia and Parkinson's disease., Scientific Reports, Vol.13, No.1, 2023. (要約) Abnormal skull shape has been reported in brain disorders. However, no studies have investigated cranial geometry in neurodegenerative disorders. This study aimed to evaluate the cranial geometry of patients with dystonia or Parkinson's disease (PD). Cranial computed tomography images of 36 patients each with idiopathic dystonia (IDYS), PD, and chronic subdural hematoma (CSDH) were analyzed. Those with IDYS had a significantly higher occipital index (OI) than those with CSDH (p = 0.014). When cephalic index (CI) was divided into the normal and abnormal groups, there was a significant difference between those with IDYS and CSDH (p = 0.000, α = 0.017) and between PD and CSDH (p = 0.031, α = 0.033). The age of onset was significantly correlated with the CI of IDYS (τ = - 0.282, p = 0.016). The Burke-Fahn-Marsden Dystonia Rating Scale motor score (BFMDRS-M) showed a significant correlation with OI in IDYS (τ = 0.372, p = 0.002). The cranial geometry of patients with IDYS was significantly different from that of patients with CSDH. There was a significant correlation between age of onset and CI, as well as between BFMDRS-M and OI, suggesting that short heads in the growth phase and skull balance might be related to the genesis of dystonia and its effect on motor symptoms. (キーワード) Humans / Dystonia / Parkinson Disease / Treatment Outcome / Deep Brain Stimulation / Dystonic Disorders / Skull / Hematoma, Subdural, Chronic / Globus Pallidus (徳島大学機関リポジトリ) ● Metadata: 118394 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-023-37833-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37420081 ● Search Scopus @ Elsevier (PMID): 37420081 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-37833-3 (徳島大学機関リポジトリ: 118394, DOI: 10.1038/s41598-023-37833-3, PubMed: 37420081)
4.	Nobuaki Yamamoto, Kazutaka Kuroda, Yuki Yamamoto, Izumi Yamaguchi, Shu Sogabe, Kenji Shimada, Ryoma Morigaki, Yasuhisa Kanematsu, Yuishin Izumi and Yasushi Takagi : Long-sheath Introducer-assisted Revascularization (L-SHARE) Technique for Treating Large-vessel Occlusion by a Giant Clot, Internal Medicine, Vol.62, No.6, 909-913, 2023. (要約) Revascularization for common carotid artery (CCA) occlusion might be difficult. We reported our strategy for revascularizing CCA occlusion by giant clots. A 94-year-old woman was transferred to our hospital because of right hemiparesis and aphasia. CCA occlusion and giant clots were detected on ultrasonography. We performed mechanical thrombectomy using a 9-Fr balloon-guiding catheter, stent retriever, and aspiration catheter through a 9-Fr long-sheath introducer [long-sheath introducer-assisted revascularization (L-SHARE) technique]. We successfully recanalized CCA occlusion using this method. The L-SHARE technique might be useful for recanalization of CCA occlusion. (キーワード) mechanical thrombectomy / long-sheath introducer / giant clot / cerebral large-vessel occlusion (徳島大学機関リポジトリ) ● Metadata: 118794 (出版サイトへのリンク) ● Publication site (DOI): 10.2169/internalmedicine.0089-22 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35945008 ● CiNii @ 国立情報学研究所 (CRID): 1390576900004177024 ● Search Scopus @ Elsevier (PMID): 35945008 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.0089-22 (徳島大学機関リポジトリ: 118794, DOI: 10.2169/internalmedicine.0089-22, PubMed: 35945008, CiNii: 1390576900004177024)
5.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 循環器病を防ぐために徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, 四国医学雑誌, Vol.78, No.5-6, 135-138, 2022年. (要約) Cerebrovascular and cardiovascular disease are the main causes of death in Japan. The leading causes of the need for long-term care in Japan are also cerebrovascular and cardiovascular disease, which together account for more than one-fourth of the total. The Cerebrovascular and Cardiovascular Disease Control Act, of Japanese national law, was promulgated by a legislative act in 2018. On the basis of the Cerebrovascular and Cardiovascular Disease Control Act, the Ministry of Health, Labour and Welfare, Japan, published the Japanese National Plan for Promotion of Measures Against Cerebrovascular and Cardiovascular Disease (Japanese National Plan) in 2020. By the example of the Japanese National Plan, Tokushima prefecture established a cerebrovascular and cardiovascular disease countermeasure promotion plan to progress cerebrovascular and cardiovascular disease measures according to their own circumstances. One of the important measures of the plan is improving emergency transportation systems. Patients with intracranial large vessel occlusion strokes should be served by direct transfer to endovascular capable centers avoiding delays by misguided transfer to primary stroke centers. Considering the limited availability of endovascular capable centers, accurate identification of patients with high probability of having large vessel occlusion strokes in the prehospital setting is importance. To address this problem, we introduced prehospital scale called Field Assessment Stroke Triage for Emergency Destination (FAST-ED) on emergency transportation systems in Tokushima city. (キーワード) Cerebrovascular and cardiovascular disease / emergency transportation systems / prehospital scale (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050295181679880704 (CiNii: 1050295181679880704)
6.	黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 山口泉, 島田健司, 兼松康久, 宮本健志, 髙木康志 : 脳静脈洞血栓症に対して経皮的血栓回収術を行った3例, 四国医学雑誌, Vol.78, No.5-6, 221-226, 2022年.
7.	山本雄貴, 山本伸昭, 黒田一駿, 和泉唯信, 兼松康久, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志 : 徳島市におけるアプリケーションを用いた脳主幹動脈閉塞診断スケールの活用,, 四国医学雑誌, Vol.78, No.5,6, 248-249, 2022年.
8.	J Fujikawa, Ryoma Morigaki, Nobuaki Yamamoto, H Nakanishi, T Oda, Yuishin Izumi and Yasushi Takagi : Diagnosis and Treatment of Tremor in Parkinson's Disease Using Mechanical Devices, Life, Vol.13, No.1, 78, 2022. (要約) Parkinsonian tremors are sometimes confused with essential tremors or other conditions. Recently, researchers conducted several studies on tremor evaluation using wearable sensors and devices, which may support accurate diagnosis. Mechanical devices are also commonly used to treat tremors and have been actively researched and developed. Here, we aimed to review recent progress and the efficacy of the devices related to Parkinsonian tremors. The PubMed and Scopus databases were searched for articles. We searched for "Parkinson disease" and "tremor" and "device". Eighty-six articles were selected by our systematic approach. Many studies demonstrated that the diagnosis and evaluation of tremors in patients with PD can be done accurately by machine learning algorithms. Mechanical devices for tremor suppression include deep brain stimulation (DBS), electrical muscle stimulation, and orthosis. In recent years, adaptive DBS and optimization of stimulation parameters have been studied to further improve treatment efficacy. Due to developments using state-of-the-art techniques, effectiveness in diagnosing and evaluating tremor and suppressing it using these devices is satisfactorily high in many studies. However, other than DBS, no devices are in practical use. To acquire high-level evidence, large-scale studies and randomized controlled trials are needed for these devices. (徳島大学機関リポジトリ) ● Metadata: 118913 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/life13010078 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36676025 ● Search Scopus @ Elsevier (PMID): 36676025 ● Search Scopus @ Elsevier (DOI): 10.3390/life13010078 (徳島大学機関リポジトリ: 118913, DOI: 10.3390/life13010078, PubMed: 36676025)
9.	Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Nobuaki Yamamoto, Kazuhisa Miyake, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, 山本陽子, Kazutaka Kuroda and Yasushi Takagi : Single-session hematoma removal and transcortical venous approach for coil embolization of an isolated transverse-sigmoid sinus dural arteriovenous fistula in a hybrid operating room: illustrative case, Journal of Neurosurgery. Case Lessons, Vol.3, No.21, CASE2267, 2022. (要約) Dural arteriovenous fistula (DAVF) can present with massive hematoma, which sometimes requires emergent removal. Therefore, a surgical strategy for single-session hematoma removal and shunt occlusion in the same surgical field is important. A 73-year-old man was transferred to the authors' hospital with a headache. Brain computed tomography (CT) revealed an intracerebral hematoma in the right temporoparietal lobe (hematoma volume 12 ml). A cerebral angiogram revealed a right isolated transverse-sigmoid sinus (TSS)-DAVF fed by the occipital artery and middle meningeal artery. There was cortical venous reflux into the Labbé vein and posterior parietal vein. Percutaneous transarterial and transvenous embolization were unsuccessful. The following day, his consciousness level acutely declined with a headache, and brain CT showed hematoma expansion (hematoma volume 41 ml) with a midline shift. Therefore, the authors performed single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF in a hybrid operating room. His postoperative course was uneventful. No recurrence was observed 3 months postoperatively on cerebral angiography. Single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF is considered in cases with massive hematoma. This strategy is useful, considering recent developments in hybrid operating rooms. (出版サイトへのリンク) ● Publication site (DOI): 10.3171/CASE2267 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35734231 ● Summary page in Scopus @ Elsevier: 2-s2.0-85160834258 (DOI: 10.3171/CASE2267, PubMed: 35734231, Elsevier: Scopus)
10.	Joji Fujikawa, Ryoma Morigaki, Nobuaki Yamamoto, Teruo Oda, Hiroshi Nakanishi, Yuishin Izumi and Yasushi Takagi : Therapeutic Devices for Motor Symptoms in Parkinson's Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials., Frontiers in Aging Neuroscience, Vol.14, 2022. (要約) Invasive and non-invasive medical devices have unique characteristics, and several RCTs have been conducted for each device. Invasive devices are more effective, while non-invasive devices are less effective and have lower hurdles and risks. It is important to understand the characteristics of each device and capitalize on these. (徳島大学機関リポジトリ) ● Metadata: 117340 (出版サイトへのリンク) ● Publication site (DOI): 10.3389/fnagi.2022.807909 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35462692 ● Search Scopus @ Elsevier (PMID): 35462692 ● Search Scopus @ Elsevier (DOI): 10.3389/fnagi.2022.807909 (徳島大学機関リポジトリ: 117340, DOI: 10.3389/fnagi.2022.807909, PubMed: 35462692)
11.	Yoshiteru Tada, Toshitaka Fujihara, Kenji Shimada, Nobuaki Yamamoto, Hiroki Yamazaki, Yuishin Izumi, Masafumi Harada, Yasuhisa Kanematsu and Yasushi Takagi : Seizure types associated with negative arterial spin labeling and positive diffusion-weighted imaging on peri-ictal magnetic resonance imaging, Journal of the Neurological Sciences, Vol.436, 1-8, 2022. (要約) Arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) are useful for assessing hyperperfusion and cytotoxic edema, respectively, caused by acute seizures. This study investigated the clinical characteristics associated with normal ASL findings and DWI abnormalities in patients with acute seizures. Overall, 41 patients with ASL and DWI images that were obtained within 48 h of focal onset seizure diagnosis, due to epilepsy or acute symptomatic seizures, were divided into groups based on initial ASL findings (ASL-negative vs. ASL-positive), and DWI abnormalities (DWI-negative vs. DWI-positive). The diagnosis was made based on seizure semiology, electroencephalography, and conventional imaging modalities. ASL and DWI abnormalities were based on visual assessment. Of the 41 patients, eight (19.5%) displayed normal ASL findings. The proportion of patients with focal aware seizures (FAS) was significantly higher among ASL-negative patients (62.5%) than that in ASL-positive patients (15.2%); the proportion of patients with focal impaired awareness seizures (FIAS) was significantly lower among ASL-negative patients (12.5%) than that among ASL-positive patients (57.6%). Hyperintensity findings on DWI were observed in 12 patients (29.3%, DWI-positive). The proportion of patients with FIAS was significantly higher among DWI-positive patients (75.0%) than that among DWI-negative patients (37.9%). Multivariate analysis revealed that FAS and FIAS were associated with normal ASL findings (odds ratio [OR]: 21.37, P = 0.010) and DWI abnormalities (OR = 6.11, P = 0.028). A diagnosis of seizures should not be excluded based on normal ASL findings, especially in patients with FAS. FIAS may be a risk factor for neuronal damage caused by seizure activity. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jns.2022.120223 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35279594 ● Summary page in Scopus @ Elsevier: 2-s2.0-85126008460 (DOI: 10.1016/j.jns.2022.120223, PubMed: 35279594, Elsevier: Scopus)
12.	Yuki Yamamoto, Nobuaki Yamamoto, Yasuhisa Kanematsu, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Shu Sogabe, Kenji Shimada, Yasushi Takagi and Yuishin Izumi : The claw sign predicts first-pass effect in mechanical thrombectomy for cerebral large vessel occlusion in the anterior circulation, Surgical Neurology International, Vol.13, No.72, 1-7, 2022. (要約) Mechanical thrombectomy (MT) is an effective treatment for acute cerebral large vessel occlusion (LVO). Complete recanalization of vessels in a single procedure is defined as the first-pass effect (FPE) and is associated with good prognosis. In this study, angiographic clot protruding sign termed the "claw sign," was examined as candidate preoperative imaging factor for predicting the FPE. We retrospectively analyzed data from 91 consecutive patients treated for acute LVO in the anterior circulation by MT between January 2014 and December 2019. The claw sign was defined as a thrombus that protruded proximally by more than half of the diameter of the parent artery. Radiological findings such as claw sign, clinical and etiological features, and outcomes were compared between groups with and without successful FPE. Multivariate analysis was conducted to evaluate perioperative factors associated with FPE. FPE was achieved in 26 of 91 (28.6%) patients and the claw sign was observed in 34 of 91 (37.4%) patients. The claw sign was significantly more frequent in the successful FPE group than in the failed FPE group (53.8% vs. 30.8%; = 0.040). After the multivariate analysis, the claw sign was the only pretreatment parameter that could predict FPE (odds ratio, 2.67; 95% confidence interval, 1.01-7.06; = 0.047). The claw sign is an angiographic imaging factor that might predict FPE after MT for anterior circulation acute ischemic stroke. (徳島大学機関リポジトリ) ● Metadata: 117192 (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_1160_2021 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35242438 ● Search Scopus @ Elsevier (PMID): 35242438 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_1160_2021 (徳島大学機関リポジトリ: 117192, DOI: 10.25259/SNI_1160_2021, PubMed: 35242438)
13.	大崎裕亮, 島かさ音, 山本伸昭, 山﨑博輝, 佐藤健太, 和泉唯信 : 血管炎性ニューロパチー様の臨床像で発症した抗Hu抗体陽性脳脊髄炎の1例, Peripheral Nerve, Vol.33, No.1, 136-143, 2022年.
14.	Masaaki Korai, Yasuhisa Kanematsu, Izumi Yamaguchi, Tadashi Yamaguchi, Yuki Yamamoto, Nobuaki Yamamoto, Takeshi Miyamoto, Kenji Shimada, Junichiro Satomi, Mami Hanaoka, Kazuhito Matsuzaki, Koichi Satoh and Yasushi Takagi : Subarachnoid Hemorrhage Due to Rupture of Vertebral Artery Dissecting Aneurysms: Treatments, Outcomes, and Prognostic Factors, World Neurosurgery, Vol.152, e86-e93, 2021. (要約) Mortality rate after subarachnoid hemorrhage due to rupture of vertebral artery dissecting aneurysms (VADAs) is high; endovascular coil trapping is the first-line therapy to prevent rerupture. To select optimal treatments, the positional relationship between the VADA and posterior inferior cerebellar artery (PICA) and the morphology of the contralateral vertebral artery must be considered, and outcome predictors of different treatment methods and their possible complications must be identified. We retrospectively studied 44 patients with ruptured VADAs who had undergone endovascular or surgical treatment. VADA morphology was assessed on conventional preoperative angiograms, and VADAs were categorized based on their site in relation to the PICA. VADA site, treatment method, and complications were used to identify prognostic factors. The sites of the 44 VADAs were PICA-proximal (n = 3), PICA-distal (n = 22), PICA-absent (n = 7), and PICA-involved (n = 12). Treatments included internal coil trapping (n = 30), proximal coil occlusion (n = 5), and stent placement (n = 3); surgical flow alteration via an occipital artery-PICA bypass and ligation at the proximal vertebral artery and the PICA origin was performed in 6 patients. Periprocedural rebleeding was associated with a poor outcome. Internal coil trapping prevented the rerupture of PICA-proximal and PICA-absent VADAs, and flow alteration prevented rerupture of PICA-involved VADAs; there were no complications directly attributable to these procedures. Periprocedural rebleeding was a poor prognostic factor. Internal trapping of PICA-proximal and PICA-absent VADAs and flow alteration in PICA-involved VADAs prevented rerupture. (キーワード) Adult / Aged / Aged, 80 and over / Aneurysm, Ruptured / Follow-Up Studies / Humans / Male / Middle Aged / Prognosis / Retrospective Studies / Subarachnoid Hemorrhage / Treatment Outcome / Vertebral Artery Dissection (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.wneu.2021.05.018 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34051365 ● Search Scopus @ Elsevier (PMID): 34051365 ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2021.05.018 (DOI: 10.1016/j.wneu.2021.05.018, PubMed: 34051365)
15.	Ryoma Morigaki, Ryosuke Miyamoto, Taku Matsuda, Kazuhisa Miyake, Nobuaki Yamamoto and Yasushi Takagi : Dystonia and cerebellum: From bench to bedside, Life, Vol.11, No.8, 776, 2021. (徳島大学機関リポジトリ) ● Metadata: 116560 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/life11080776 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.3390/life11080776 (徳島大学機関リポジトリ: 116560, DOI: 10.3390/life11080776)
16.	Yasuhisa Kanematsu, Kenji Shimada, Yoshiteru Tada, Masaaki Korai, Takeshi Miyamoto, Shu Sogabe, Izumi Yamaguchi, Yoko Ymamoto, Nobuaki Yamamoto, Yuki Yamamoto, Koichi Satoh and Yasushi Takagi : Coil embolization with overlapping horizontal low-profile stents to treat a giant thrombosed fetal posterior cerebral aneurysm using contralateral approach through anterior communicating artery: Case report., Surgical Neurology International, Vol.12, No.347, 2021. (要約) The treatment of internal carotid artery (ICA) - posterior communicating artery aneurysms (ICPC aneurysms) is challenging when a fetal posterior cerebral artery (PCA) arises from the saccular neck. This complex angioarchitecture renders endovascular approaches difficult. Giant thrombosed IC-PC aneurysms are also hard to treat by endovascular coiling because its flow-diversion effect is insufficient. We report the first case of a ruptured giant thrombosed IC-PC aneurysm associated with a fetal PCA that was successfully treated by coil embolization with retrograde overlap horizontal stenting using low-profile stents introduced through the contralateral ICA. The aneurysm was completely occluded and follow-up MRI scans demonstrated the reduction of the aneurysmal size. Our technique is advantageous because low-profile stents can be used to treat lesions not accessible with flow-diverter stents due their presence in complex angioarchitectures, and overlap stenting may have flow-diversion effects that can result in the complete occlusion of giant thrombosed aneurysms. (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_533_2021 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34345487 ● Search Scopus @ Elsevier (PMID): 34345487 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_533_2021 (DOI: 10.25259/SNI_533_2021, PubMed: 34345487)
17.	Nobuaki Yamamoto, Yuki Yamamoto, Izumi Yamaguchi, Shu Sogabe, Takeshi Miyamoto, Kenji Shimada, Yasuhisa Kanematsu, Ryoma Morigaki, Yuishin Izumi and Yasushi Takagi : Percutaneous Transluminal Angioplasty and Stenting Using an Aspiration Catheter, Journal of Neuroendovascular Therapy, Vol.16, No.5, 277-282, 2021. (要約) <p><b>Objective</b>: During percutaneous transluminal angioplasty (PTA) for the vertebral artery, occlusion of the subclavian artery using a balloon guiding catheter may be useful to prevent embolism of clots and/or debris distal to an atherosclerotic lesion. However, when placing a balloon guiding catheter at the intended vessels is difficult, it may be useful to use an aspiration catheter (AC) for mechanical thrombectomy as an intermediate catheter to suction way clots and/or debris. We report two cases in which PTA was performed for an atherosclerotic lesion at the intracranial vertebral artery using an AC, which ended without complications.</p><p><b>Case Presentations</b>: Case 1: A 74-year-old man presented with dysarthria and was admitted to our hospital. MRI revealed severe left vertebral artery stenosis and diffuse cerebral infarct areas at the territory of the posterior circulation. The patient had an abdominal aortic aneurysm and abnormally shaped left tortuous subclavian artery. Therefore, we performed PTA and stenting via the left brachial artery. We guided a 6-Fr long sheath to the left subclavian artery, and a 6-Fr AC for thrombectomy was guided through the long sheath to the V4 portion of the left vertebral artery. Thereafter, PTA was carried out under manual aspiration from the AC. As restenosis at the atherosclerotic lesion occurred after PTA, we performed stenting using a coronary stent system for this lesion under manual aspiration from the AC. No new infarct areas were observed on post-procedural MRI. Case 2: A 74-year-old woman presented with dysarthria and was admitted to our hospital. MRI demonstrated basilar artery occlusion and diffuse cerebral infarct areas at the territory of the posterior circulation. As her symptom worsened after admission, we performed urgent mechanical thrombectomy. We first performed thrombectomy using a stent retriever and then performed PTA and stenting (PTAS) for residual basilar artery stenosis via the AC under manual aspiration.</p><p><b>Conclusion</b>: When it is difficult to place a guiding catheter at the intended vessels during PTA, an AC may be useful to prevent distal embolization.</p> (キーワード) percutaneous transluminal angioplasty / aspiration catheter (出版サイトへのリンク) ● Publication site (DOI): 10.5797/jnet.cr.2021-0030 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390573593425698304 ● Search Scopus @ Elsevier (DOI): 10.5797/jnet.cr.2021-0030 (DOI: 10.5797/jnet.cr.2021-0030, CiNii: 1390573593425698304)
18.	Manabu Ishihara, Nobuto Nakanishi, Rie Tsutsumi, Kanako Hara, Kyoka Machida, Nobuaki Yamamoto, Yasuhisa Kanematsu, Hiroshi Sakaue, Jun Oto and Yasushi Takagi : Elevated Urinary Titin and its Associated Clinical Outcomes after Acute Stroke., Journal of Stroke & Cerebrovascular Diseases, Vol.30, No.3, 2021. (要約) Forty-one patients were included (29 male; age, 68 ± 15 years), 29 had ischemic stroke, 8 had intracerebral hemorrhage, and 4 had subarachnoid hemorrhage. The levels of urinary titin on days 1, 3, 5, and 7 were 9.9 (4.7-21.1), 16.2 (8.6-22.0), 8.9 (4.8-15.2), and 8.7 (3.6-16.2) pmol/mg Cr, respectively. The peak urinary titin level was associated with the mRS score (r = 0.55, p < 0.01), the NIHSS score (r = 0.72, p < 0.01), and the BI (r = -0.59, p < 0.01) upon hospital discharge. In multivariate analysis, the peak urinary titin was associated with poor outcome (p = 0.03). (キーワード) Aged / Aged, 80 and over / Biomarkers / Connectin / Disability Evaluation / Female / Functional Status / Humans / Male / Middle Aged / Patient Discharge / Predictive Value of Tests / Prospective Studies / Recovery of Function / Stroke / Time Factors / Treatment Outcome / Up-Regulation / Urinalysis (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2020.105561 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33360523 ● Search Scopus @ Elsevier (PMID): 33360523 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jstrokecerebrovasdis.2020.105561 (DOI: 10.1016/j.jstrokecerebrovasdis.2020.105561, PubMed: 33360523)
19.	Daisy Ma Tabuena, Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Nobuaki Yamamoto, Kazuhisa Miyake, Taku Matsuda, Yuishin Izumi, Yasushi Takagi, P Rollin Tabuena and Toshitaka Kawarai : Ataxia with vitamin E deficiency in the Philippines: A case report of two siblings., The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 400-403, 2021. (要約) Here we report two siblings with ataxia and peripheral neuropathy. One patient showed head tremors. Genetic analysis revealed a mutation in the hepatic α-tocopherol transfer protein (α-TTP) gene (TTPA) on chromosome 8q13. They were diagnosed with ataxia with vitamin E deficiency which is firstly reported in the Philippines. As the symptoms of ataxia with vitamin E deficiency can be alleviated with lifelong vitamin E administration, differential diagnosis from similar syndromes is important. In addition, ataxia with vitamin E deficiency causes movement disorders. Therefore, a common hereditary disease in the Philippines, X-linked dystonia-parkinsonism, could be another differential diagnosis. The Philippines is an archipelago comprising 7,107 islands, and the prevalence of rare hereditary diseases among the populations of small islands is still unclear. For neurologists, establishing a system of genetic diagnosis and counseling in rural areas remains challenging. These unresolved problems should be addressed in the near future. J. Med. Invest. 68 : 400-403, August, 2021. (キーワード) Ataxia / Humans / Philippines / Siblings / Vitamin E Deficiency (徳島大学機関リポジトリ) ● Metadata: 116574 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.68.400 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759169 ● Search Scopus @ Elsevier (PMID): 34759169 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.400 (徳島大学機関リポジトリ: 116574, DOI: 10.2152/jmi.68.400, PubMed: 34759169)
20.	Nobuaki Yamamoto, Yuishin Izumi, Yuki Yamamoto, K Kuroda, Izumi Yamaguchi, Shu Sogabe, Takeshi Miyamoto, Kenji Shimada, Yasuhisa Kanematsu, Ryoma Morigaki and Yasushi Takagi : Factors associated with DWI-ASPECTS score in patients with acute ischemic stroke due to cerebral large vessel occlusion, Clinical Neurology and Neurosurgery, Vol.199, 106316, 2020. (要約) The Alberta Stroke Program Early CT score (ASPECTS) of patients with acute ischemic stroke at the time of admission varies. It is crucial to select appropriate methods of treatment, such as recombinant tissue-plasminogen activator, and/or endovascular thrombectomy. According to the recent guidelines, endovascular thrombectomy for patients with large vessel occlusion (LVO) and lesion of ischemic tissue that was not yet infarcted is effective. This result demonstrates the importance of patient selection based on neuroradiological imaging. However, there are many patients who are judged as ineligibility for recanalization therapy because of presence of large ischemic core, indicating unfavorable ASPECTS, at the time of admission. We investigated the factors associated with favorable diffusion-weighted image (DWI)-ASPECTS score at the time of admission. We studies patients with LVO within 24 h from onset who were admitted into our hospital. We divided them into two groups, with favorable DWI-ASPECTS (≥6), and unfavorable DWI-ASPECTS (<6) at the time of admission. We investigated factors associated with favorable DWI-ASPECTS by evaluation of our patients' severity of clinical symptom, etiology, and radiological findings. This study showed that mild white matter lesion (Fazekas scale ≤1), absence of internal carotid artery (ICA) occlusion and cardioembolic stroke were independent factor of favorable DWI-ASPECTS at the time of admission. (odds ratio 12.92, p < 0.001, odds ratio 0.31, p = 0.001, odds ratio 0.16, p = 0.001, respectively) CONCLUSIONS: Absence of severe white matter lesion, cardioembolic stroke, and ICA occlusion might be associated with favorable DWI-ASPECTS at the time of admission. (キーワード) Aged / Aged, 80 and over / Brain Ischemia / Cerebrovascular Disorders / Diffusion Magnetic Resonance Imaging / Female / Humans / Ischemic Stroke / Male / Middle Aged / Patient Admission / Prospective Studies / Retrospective Studies / Severity of Illness Index (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.clineuro.2020.106316 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33161217 ● Search Scopus @ Elsevier (PMID): 33161217 ● Search Scopus @ Elsevier (DOI): 10.1016/j.clineuro.2020.106316 (DOI: 10.1016/j.clineuro.2020.106316, PubMed: 33161217)
21.	Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Koji Fujita, Taku Matsuda, Yoko Yamamoto, Masahito Nakataki, Tetsuya Okahisa, Yuki Matsumoto, Kazuhisa Miyake, Nobuaki Yamamoto, Ryuji Kaji, Yasushi Takagi and Satoshi Goto : Can Pallidal Deep Brain Stimulation Rescue Borderline Dystonia? Possible Coexistence of Functional (Psychogenic) and Organic Components., Brain Sciences, Vol.10, No.9, 636, 2020. (要約) The diagnosis and treatment of functional movement disorders are challenging for clinicians who manage patients with movement disorders. The borderline between functional and organic dystonia is often ambiguous. Patients with functional dystonia are poor responders to pallidal deep brain stimulation (DBS) and are not good candidates for DBS surgery. Thus, if patients with medically refractory dystonia have functional features, they are usually left untreated with DBS surgery. In order to investigate the outcome of functional dystonia in response to pallidal DBS surgery, we retrospectively included five patients with this condition. Their dystonia was diagnosed as organic by dystonia specialists and also as functional according to the Fahn and Williams criteria or the Gupta and Lang Proposed Revisions. Microelectrode recordings in the globus pallidus internus of all patients showed a cell-firing pattern of bursting with interburst intervals, which is considered typical of organic dystonia. Although their clinical course after DBS surgery was incongruent to organic dystonia, the outcome was good. Our results question the possibility to clearly differentiate functional dystonia from organic dystonia. We hypothesized that functional dystonia can coexist with organic dystonia, and that medically intractable dystonia with combined functional and organic features can be successfully treated by DBS surgery. (徳島大学機関リポジトリ) ● Metadata: 116502 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/brainsci10090636 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32942724 ● Search Scopus @ Elsevier (PMID): 32942724 ● Search Scopus @ Elsevier (DOI): 10.3390/brainsci10090636 (徳島大学機関リポジトリ: 116502, DOI: 10.3390/brainsci10090636, PubMed: 32942724)
22.	Yamamoto Yuki, Nobuaki Yamamoto, Koji Fujita, Fukumoto Tatsuya, Murakami Nagahisa, Hideo Mure, Yasuhisa Kanematsu, Yasushi Takagi and Yuishin Izumi : Cerebral Venous Thrombosis: An Unexpected Complication with Cerebrospinal Fluid Leaks after a Fall in a Patient with Spinocerebellar Ataxia Type 6., Internal Medicine, Vol.59, No.14, 1749-1753, 2020. (徳島大学機関リポジトリ) ● Metadata: 115918 (出版サイトへのリンク) ● Publication site (DOI): 10.2169/internalmedicine.4388-20 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32238726 ● Search Scopus @ Elsevier (PMID): 32238726 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.4388-20 (徳島大学機関リポジトリ: 115918, DOI: 10.2169/internalmedicine.4388-20, PubMed: 32238726)
23.	Nobuaki Yamamoto, Yuki Yamamoto, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yuishin Izumi and Yasushi Takagi : Cone beam-computed tomography angiography by intravenous contrast injection is reliable to evaluate patients with large vessel occlusion, Journal of Clinical Neuroscience, Vol.70, 67-71, 2019. (要約) Mechanical thrombectomy (MT) for acute ischemic stroke (AIS) patients due to emergent large vessel occlusion (ELVO) is standard treatment, the benefits, however, are highly time-sensitive. After patient eligibility for reperfusion therapy is determined by conventional radiological examinations, the time to be transferred from the department of radiological examination to angiography-suites is critical. We speculated that the time required for the diagnosis of AIS might be reduced if we could determine MT eligibility in patients with ELVO at angiography-suites. Modern angiography-suites with flat panel detectors can perform cone beam (CB)-CT. We performed CB-CTA using intravenous injection of contrast agent to evaluate occlusion sites, collateral score, and construction of vessels distal to occlusion sites and determined if CB-CTA could be useful to evaluate patients with ELVO. We included 15 patients with ELVO diagnosed by conventional MRI or CT/CTA, and investigated whether CB-CTA was reliable to diagnose occlusion sites. We also studied if collateral score on CB-CTA was associated with prognosis after successful reperfusion by MT by comparison between favorable (modified Rankin scale (mRS) 0-2), and unfavorable outcome group (mRS 3-6). There was strong agreement of occlusion sites between CB-CTA and conventional radiological examination (κ = 0.80). Collateral score determined by CB-CTA was significantly different between favorable outcome and unfavorable outcome group (median collateral score 2.3 v.s. 1.3, p = 0.040). Although prospective study of AIS patients at a radiography department is indispensable, CB-CTA performed in an angiography-suite might be useful to evaluate patients with ELVO. (キーワード) Aged / Aged, 80 and over / Brain Ischemia / Carotid Artery Thrombosis / Computed Tomography Angiography / Contrast Media / Female / Humans / Infarction, Middle Cerebral Artery / Injections, Intravenous / Male / Middle Aged / Prognosis / Reperfusion / Retrospective Studies / Thrombectomy / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jocn.2019.08.078 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31445814 ● Summary page in Scopus @ Elsevier: 2-s2.0-85070874852 (DOI: 10.1016/j.jocn.2019.08.078, PubMed: 31445814, Elsevier: Scopus)
24.	Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Masaaki Korai, Takeshi Miyamoto, Eiji Shikata, Tadashi Yamaguchi, Nobuaki Yamamoto, Yuki Yamamoto, Keiko Kitazato, Yoshihiro Okayama and Yasushi Takagi : Active Cancer and Elevated D-Dimer Are Risk Factors for In-Hospital Ischemic Stroke, Cerebrovascular Diseases Extra, Vol.9, No.3, 129-138, 2019. (要約) Little attention has been paid to the pathogenesis of in-hospital stroke, despite poor outcomes and a longer time from stroke onset to treatment. We studied the pathophysiology and biomarkers for detecting patients who progress to in-hospital ischemic stroke (IHS). Seventy-nine patients with IHS were sequentially recruited in the period 2011-2017. Their characteristics, care, and outcomes were compared with 933 patients who had an out-of-hospital ischemic stroke (OHS) using a prospectively collected database of the Tokushima University Stroke Registry. Active cancer and coronary artery disease were more prevalent in patients with IHS than in those with OHS (53.2 and 27.8% vs. 2.0 and 10.9%, respectively; p < 0.001), the median onset-to-evaluation time was longer (300 vs. 240 min; p = 0.015), and the undetermined etiology was significantly higher (36.7 vs. 2.4%; p < 0.001). Although there was no significant difference in stroke severity at onset between the groups, patients with IHS had higher modified Rankin Scale (mRS) scores (3-6) at discharge (67.1 vs. 50.3%; p = 0.004) and rates of death during hospitalization (16.5 vs. 2.9%; p < 0.001). D-dimer (5.8 vs. 0.8 µg/mL; p < 0.001) and fibrinogen (532 vs. 430 mg/dL; p = 0.014) plasma levels at the time of onset were significantly higher in patients with IHS after propensity score matching. Multivariate logistic regression analysis revealed that active cancer (odds ratio [OR] 2.30; 95% confidence interval [CI] 1.26-4.20), prestroke mRS scores 3-5 (OR 6.78; 95% CI 3.96-11.61), female sex (OR 1.57; 95% CI 1.19-2.08), and age ≥75 years (OR 2.36; 95% CI 1.80-3.08) were associated with poor outcomes. Patients with IHS had poorer outcomes than those with OHS because of a higher prevalence of active cancer and functional dependence before stroke onset. Elevated plasma levels of D-dimer and fibrinogen, especially with active cancer, can help identify patients who are at a higher risk of progression to IHS. (キーワード) Aged / Aged, 80 and over / Biomarkers / Brain Ischemia / Databases, Factual / 女性 (female) / Fibrin Fibrinogen Degradation Products / Hospital Mortality / Hospitalization / Humans / Inpatients / 日本 (Japan) / 男性 (male) / Middle Aged / Neoplasms / Prevalence / Prognosis / Registries / Retrospective Studies / Risk Assessment / Risk Factors / Stroke / Time Factors / Up-Regulation (徳島大学機関リポジトリ) ● Metadata: 115057 (出版サイトへのリンク) ● Publication site (DOI): 10.1159/000504163 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31760390 ● Summary page in Scopus @ Elsevier: 2-s2.0-85075786196 (徳島大学機関リポジトリ: 115057, DOI: 10.1159/000504163, PubMed: 31760390, Elsevier: Scopus)
25.	Yamamoto Yuki, Nobuaki Yamamoto, Yasuhisa Kanematsu, Masaaki Korai, Kenji Shimada, Yuishin Izumi and Yasushi Takagi : The Claw Sign: An angiographic Predictor of Recanalization After Mechanical Thrombectomy for Cerebral Large Vessel Occlusion., Journal of Stroke & Cerebrovascular Diseases, Vol.28, No.6, 1555-1560, 2019. (要約) Mechanical thrombectomy undoubtedly improves functional outcomes for patients with acute ischemic stroke. Although we have observed occlusion sites that protrude proximally into the vessel on angiography, termed the "claw sign," we have been unable to state its clinical significance. In this study, we aimed to determine whether the presence of a claw sign was related to recanalization success after mechanical thrombectomy. We retrospectively included 73 consecutive patients treated for acute cerebral large vessel occlusion by mechanical thrombectomy between January 2014 and December 2017. The angiographic claw sign was defined as a thrombus that protruded proximally by more than half the diameter of the parent artery. Claw sign positivity, clinical and etiological features, and outcomes were compared between groups with and without recanalization. The claw sign was observed in 29 of 73 (40%) patients and was positive significantly more frequently in those with recanalization (50.0%) than in those without recanalization (5.9%) (P < .01). By multivariate analysis, the claw sign was the only pretreatment parameter to predict successful recanalization (odds ratio, 12.50; 95% confidence interval, 1.50-103.00; P = .019). The presence of the claw sign might predict successful recanalization in patients undergoing mechanical thrombectomy for large vessel occlusion. (キーワード) Aged / Aged, 80 and over / Angiography, Digital Subtraction / Cerebral Angiography / Cerebral Arteries / Cerebrovascular Circulation / Constriction, Pathologic / Female / Humans / Intracranial Thrombosis / Male / Middle Aged / Predictive Value of Tests / Retrospective Studies / Thrombectomy / Thrombolytic Therapy / Treatment Outcome / Vascular Patency (徳島大学機関リポジトリ) ● Metadata: 114639 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2019.03.007 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30930237 ● Search Scopus @ Elsevier (PMID): 30930237 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jstrokecerebrovasdis.2019.03.007 (徳島大学機関リポジトリ: 114639, DOI: 10.1016/j.jstrokecerebrovasdis.2019.03.007, PubMed: 30930237)
26.	Nobuaki Yamamoto, Yuki Yamamoto, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yuishin Izumi, Junichiro Satomi, Yasushi Takagi and Ryuji Kaji : Simultaneous approach to tandem occlusion in acute ischemic stroke patients: Percutaneous Transluminal Angioplasty (PTA) using push wire of stent retriever, Journal of Neuroendovascular Therapy, Vol.13, No.6, 257-261, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.5797/jnet.cr.2018-0108 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001288147947776 ● Search Scopus @ Elsevier (DOI): 10.5797/jnet.cr.2018-0108 (DOI: 10.5797/jnet.cr.2018-0108, CiNii: 1390001288147947776)
27.	Yuki Yamamoto, Nobuaki Yamamoto, Junichiro Satomi, Idumi Yamaguchi, Masaaki Korai, Yasuhisa Kanematsu, Yasushi Takagi and Ryuji Kaji : Dural arteriovenous fistula in the superior orbital fissure, Surgical Neurology International, Vol.9, No.1, 95, 2018. (要約) Dural arteriovenous fistulas (dAVFs) are extremely rare in the superior orbital fissure, and they exhibit ocular symptoms similar to the dAVF in the cavernous sinus because of the intraorbital venous congestion. Hence, the distinction of these conditions is imperative because of some inherent differences in endovascular treatment techniques. A 58-year-old woman presented with a gradually worsening left eyeball protrusion and conjunctival congestion. The digital subtraction angiography revealed a dAVF with a shunting point in the left superior orbital fissure. Moreover, the inferolateral trunk of the left internal carotid artery and the left middle meningeal artery were involved as feeding arteries. Shunting blood flow drained into the facial vein through the superior ophthalmic vein (SOV) but not into the cavernous sinus, which was located just posterior to the superior orbital fissure. We performed transvenous coil embolization in the SOV through the facial vein, and the symptoms disappeared completely. We experienced a case of a dAVF in the superior orbital fissure. This case presented a possibility of the presence of one subtype of the dAVF in the part of the cavernous sinus separated at the superior orbital fissure in front. Transvenous coil embolization in the SOV through the facial vein efficiently occluded the fistula. (出版サイトへのリンク) ● Publication site (DOI): 10.4103/sni.sni_46_18 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29888029 ● Search Scopus @ Elsevier (PMID): 29888029 ● Search Scopus @ Elsevier (DOI): 10.4103/sni.sni_46_18 (DOI: 10.4103/sni.sni_46_18, PubMed: 29888029)
28.	Nobuaki Yamamoto, Junichiro Satomi, Yuki Yamamoto, Kenji Shono, Yasuhisa Kanematsu, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji : Risk Factors of Neurological Deterioration in Patients with Cerebral Infarction due to Large Artery Atherosclerosis, Journal of Stroke & Cerebrovascular Diseases, Vol.26, No.8, 1801-1806, 2017. (要約) In some patients with acute ischemic stroke, neurological deterioration (ND) is observed, and it is difficult to predict at the time of admission. Especially in some patients with large-artery atherosclerosis (LAA), aggressive medical treatments and surgical interventions might be helpful to prevent ND. Therefore, we investigated factors associated with ND in patients with LAA. We studied patients with LAA who were admitted to our hospital. We divided them into 2 groups with (group 1) and without deterioration (group 2), and evaluated their medical records, risk factors, and radiological findings, such as number of diffusion-positive lesion and degree of stenosis. Our study population consisted of 171 patients; 71 (41.5%) did and 100 (58.5%) did not suffer deterioration. By univariate analysis, blood pressure (BP), heart rate, National Institutes of Health Stroke Scale (NIHSS) score, number of diffusion-positive lesion, count of red blood cell, high-density lipoprotein, and degree of stenosis differed significantly between the 2 groups. By multivariate analysis, systolic BP (170 mm Hg, odds ratio: 7.20, P <.001) was associated with ND. Furthermore, number of diffusion-weighted image (DWI)-positive lesion (8), degree of stenosis (>80.0%), and NIHSS score (4) were also independent factors associated with ND. High BP, severity of neurological deficit at the time of admission, and radiological findings, such as degree of stenosis and number of DWI-positive lesion, are independently associated with ND in patients with LAA. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2017.04.011 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28476508 ● Search Scopus @ Elsevier (PMID): 28476508 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jstrokecerebrovasdis.2017.04.011 (DOI: 10.1016/j.jstrokecerebrovasdis.2017.04.011, PubMed: 28476508)
29.	Yasuhisa Kanematsu, Junichiro Satomi, Kazuyuki Kuwayama, Izumi Yamaguchi, Shotaroh Yoshioka, Tomoya Kinouchi, Yoshiteru Tada, Nobuaki Yamamoto, Shunji Matsubara, Kenji Shono and Shinji Nagahiro : Treatment Outcome of Carotid Artery Stenting Underwent within 14 Days of Stroke Onset - Consideration of Safety and Efficacy of Urgent Carotid Artery Stenting for Neurologically Progressing Patients, Neurologia Medico-Chirurgica, Vol.57, No.6, 278-283, 2017. (要約) As the safety and effectiveness of urgent carotid artery stenting (CAS) for neurologically progressing patients remain controversial, we retrospectively analyzed the outcome of urgent CAS based on the patients' pathophysiological condition and neuroimaging findings. We divided 71 patients who underwent CAS within 14 days of stroke onset into two groups. Group 1 (n = 35) was comprised of patients with progressing neurologic signs and a reversible ischemic penumbra on magnetic resonance images (MRI). They were treated by urgent CAS. Group 2 (n = 36) was neurologically stable and underwent prophylactic CAS. In all patients we recorded the National Institutes of Health Stroke Scale (NIHSS) score and the modified Rankin scale (mRS). Urgent CAS resulted in significant improvement in the NIHSS score, when compared before and after CAS in group 1 (5.3 ± 4.3, P < 0.01). The rate of good outcomes (mRS 0-2 at 3 months post-CAS) was 48.6% in group 1, and 75% in group 2. The cumulative incidence of ipsilateral stroke between 31 days and 1 year was 5.9% in group 1, and 0% in group 2. The procedural complication rate was similar in both groups (group 1: 5.7%, n = 2; group 2: 5.6%, n = 2). No patient suffered a symptomatic intracerebral hemorrhage. When the pathophysiological status and neuroimaging findings are used to determine patient eligibility for urgent CAS, this treatment improve neurologic outcome and can be performed as safely as prophylactic CAS in our cohort of patients with acute ischemic stroke. (出版サイトへのリンク) ● Publication site (DOI): 10.2176/nmc.oa.2016-0236 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28381652 ● Search Scopus @ Elsevier (PMID): 28381652 ● Search Scopus @ Elsevier (DOI): 10.2176/nmc.oa.2016-0236 (DOI: 10.2176/nmc.oa.2016-0236, PubMed: 28381652)
30.	Shu Sogabe, Junichiro Satomi, Yoshiteru Tada, Yasuhisa Kanematsu, Kazuyuki Kuwayama, Kenji Yagi, Shotaroh Yoshioka, Yoshifumi Mizobuchi, Hideo Mure, Izumi Yamaguchi, Takashi Abe, Nobuaki Yamamoto, Keiko Kitazato, Ryuji Kaji, Masafumi Harada and Shinji Nagahiro : Intra-arterial high signals on arterial spin labeling perfusion images predict the occluded internal carotid artery segment, Neuroradiology, Vol.59, No.6, 587-595, 2017. (要約) Arterial spin labeling (ASL) involves perfusion imaging using the inverted magnetization of arterial water. If the arterial arrival times are longer than the post-labeling delay, labeled spins are visible on ASL images as bright, high intra-arterial signals (IASs); such signals were found within occluded vessels of patients with acute ischemic stroke. The identification of the occluded segment in the internal carotid artery (ICA) is crucial for endovascular treatment. We tested our hypothesis that high IASs on ASL images can predict the occluded segment. Our study included 13 patients with acute ICA occlusion who had undergone angiographic and ASL studies within 48 h of onset. We retrospectively identified the high IAS on ASL images and angiograms and recorded the occluded segment and the number of high IAS-positive slices on ASL images. The ICA segments were classified as cervical (C1), petrous (C2), cavernous (C3), and supraclinoid (C4). Of seven patients with intracranial ICA occlusion, five demonstrated high IASs at C1-C2, suggesting that high IASs could identify stagnant flow proximal to the occluded segment. Among six patients with extracranial ICA occlusion, five presented with high IASs at C3-C4, suggesting that signals could identify the collateral flow via the ophthalmic artery. None had high IASs at C1-C2. The mean number of high IAS-positive slices was significantly higher in patients with intra- than extracranial ICA occlusion. High IASs on ASL images can identify slow stagnant and collateral flow through the ophthalmic artery in patients with acute ICA occlusion and help to predict the occlusion site. (徳島大学機関リポジトリ) ● Metadata: 111444 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00234-017-1828-9 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28397019 ● Search Scopus @ Elsevier (PMID): 28397019 ● Search Scopus @ Elsevier (DOI): 10.1007/s00234-017-1828-9 (徳島大学機関リポジトリ: 111444, DOI: 10.1007/s00234-017-1828-9, PubMed: 28397019)
31.	Nobuaki Yamamoto, Junichiro Satomi, Yuki Yamamoto, Izumi Yamaguchi, Shinji Nagahiro and Ryuji Kaji : Usefulness of 3-Tesla magnetic resonance arterial spin-labeled imaging for diagnosis of cranial dural arteriovenous fistula, Journal of the Neurological Sciences, Vol.372, 428-432, 2017. (要約) Conventional digital subtraction angiography (DSA) has been a useful tool for the diagnosis of cranial dural arteriovenous fistula (cDAVF). In most patients with cDAVF, blood flow through the arteriovenous shunt was pooled at diseased veins and/or sinuses. Therefore, we speculated that pooled blood at diseased veins in patients with cDAVF could be detected on arterial spin-labeled imaging (ASL). The purpose of the present study was to investigate the usefulness of ASL to detect cDAVF. Consecutive 13 patients with cDAVF who were admitted to our hospital between April 2013 and September 2016 were included in our study. We performed magnetic resonance imaging (MRI), including ASL, before DSA and within 7days after treatment for all of our patients. The accuracy for diagnosis of cDAVF was compared between conventional MRI findings and ASL findings. We also investigated the difference in ASL findings before and after treatment. We could detect venous ASL signals in 12 patients, and this was more sensitive for diagnosis of cDAVF versus conventional MRI findings. ASL found the same location of cDAVF as conventional angiography. After successful treatment, venous ASL signals disappeared. ASL might be useful to detect cDAVF and predict the location of diseased sinuses. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jns.2016.11.011 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27842984 ● Search Scopus @ Elsevier (PMID): 27842984 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2016.11.011 (DOI: 10.1016/j.jns.2016.11.011, PubMed: 27842984)
32.	Kenji Shono, Junichiro Satomi, Yoshiteru Tada, Yasuhisa Kanematsu, Nobuaki Yamamoto, Yuishin Izumi, Ryuji Kaji, Masafumi Harada and Shinji Nagahiro : Optimal Timing of Diffusion-Weighted Imaging to Avoid False-Negative Findings in Patients With Transient Ischemic Attack, Stroke, Vol.48, No.7, 1990-1992, 2017. (要約) We aimed to investigate the optimal timing of diffusion-weighted imaging (DWI) in patients with transient ischemic attack (TIA). Seventy-three consecutive patients with TIA underwent DWI on admission (initial DWI) and at 24 hours after admission (second DWI). Patients were divided into 2 groups based on initial DWI findings in relation to the second examination: false negative (group 1) and other (group 2). The probability of initial false-negative findings was determined for each hour from TIA onset to initial DWI. Multivariate analysis was used to evaluate the independent risk factors associated with false-negative findings on initial DWI. Of the 73 patients examined (56 men; mean age, 68 years), 9 (12%) were categorized into group 1. The latency from TIA onset to initial DWI was 1.7±0.6 hours for group 1 (range, 1-2.8 hours) and 3.3±2.6 hours for group 2 (range, 35 minutes to 12 hours). The probability of false-negative findings on initial DWI decreased in a time-dependent manner (25%, 21%, and 7% for 1, 2, and 3 hours, respectively), and no false-negative findings were observed on initial DWI performed at >3 hours from symptom onset. Short latency (2 hours) from TIA onset to initial DWI was an independent risk factor related to false-negative findings (odds ratio, 13.11; 95% confidence interval, 1.07-161.38; P=0.045). If the duration between TIA symptom onset and initial DWI is <2 hours, a repeat examination should be performed to minimize the risk of false-positive findings. (キーワード) Aged / Aged, 80 and over / Diffusion Magnetic Resonance Imaging / False Negative Reactions / Female / Humans / Ischemic Attack, Transient / Male / Middle Aged / Retrospective Studies / Risk Factors / Sensitivity and Specificity / Time Factors (出版サイトへのリンク) ● Publication site (DOI): 10.1161/STROKEAHA.117.014576 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28536173 ● Summary page in Scopus @ Elsevier: 2-s2.0-85019546161 (DOI: 10.1161/STROKEAHA.117.014576, PubMed: 28536173, Elsevier: Scopus)
33.	Izumi Yamaguchi, Junichiro Satomi, Nobuaki Yamamoto, Shotaroh Yoshioka, Yoshiteru Tada, Kenji Yagi, Yasuhisa Kanematsu and Shinji Nagahiro : Coexistence of Quasi-moyamoya Disease and POEMS Syndrome in a Patient with Intracranial Hemorrhage: A Case Report and Literature Review, NMC Case Report Journal, Vol.4, 5-9, 2017. (要約) POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare paraneoplastic syndrome elicited by plasma cell dyscrasia. Its clinical manifestations are multiple and stroke is not a recognized feature. A 44-year-old woman with a 3-month history of bilateral lower extremity sensorimotor disturbance was admitted to our hospital. Examinations revealed polyneuropathy, organomegaly, hypothyroidism, monoclonal gammopathy, pelvic plasmacytoma, and elevated serum vascular endothelial growth factor (VEGF) levels. A diagnosis of POEMS was made. Her condition was improved by radiation therapy of her pelvic plasmacytoma and she continued to be seen on an outpatient basis. Five years after her first admission she was re-admitted with sudden-onset right hemiparesis. A brain computed tomography (CT) scan revealed a left intracranial hemorrhage and magnetic resonance (MR) angiography and cerebral angiography showed occlusion of the proximal portion of the bilateral middle cerebral artery and narrowing of the bilateral internal carotid artery at the terminal portion; moyamoya vessels were seen. This is the first report of a patient whose intracranial hemorrhage was attributable to quasi-moyamoya disease associated with POEMS syndrome. We suggest that the POEMS syndrome be ruled out in the differential diagnosis of patients presenting with atypical stroke, multivessel stenotic lesions (moyamoya vessels), and polyneuropathy. (出版サイトへのリンク) ● Publication site (DOI): 10.2176/nmccrj.cr.2016-0106 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28664017 ● Search Scopus @ Elsevier (PMID): 28664017 ● Search Scopus @ Elsevier (DOI): 10.2176/nmccrj.cr.2016-0106 (DOI: 10.2176/nmccrj.cr.2016-0106, PubMed: 28664017)
34.	蔭山彩人, 兼松康久, 山口泉, 山本伸昭, 木内智也, 多田恵曜, 西京子, 里見淳一郎, 永廣信治 : 徳島大学病院脳卒中センターにおける院内発症脳卒中の検討, 四国医学雑誌, Vol.72, No.5-6, 195-198, 2016年. (要約) We assessed the current status of patients with acute in-hospital stroke. 63 patients with acute in-hospital stroke were enrolled. The most prevalent subtype of stroke was embolism(n＝24). The main cause of hospitalization were malignant neoplasms in15. Only 5 patients were treated with rt-PA, 8 patients received endovascular interventions. In-hospital stroke is a sever complication of in-patients and is associated with an unfavorable prognosis, but endovascular interventions offer safe and feasible therapeutic treatment options. (キーワード) in-hospital ischemic stroke / rt-PA / stroke care services / endovascular interventions (徳島大学機関リポジトリ) ● Metadata: 110402 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050845762395251200 (徳島大学機関リポジトリ: 110402, CiNii: 1050845762395251200)
35.	布村俊幸, 兼松康久, 山上圭, 西京子, 山本雄貴, 山本伸昭, 安積麻衣, 西山徹, 鹿草宏, 山口泉, 吉岡正太郎, 里見淳一郎, 永廣信治 : 徳島大学病院脳卒中センターに搬送されたrt-PA静注療法の"Drip and Ship"症例における検討, 四国医学雑誌, Vol.72, No.3-4, 107-112, 2016年. (要約) Recently,"Drip and Ship"treatment conducted in collaboration of a hospital in remote area and an institution capable of emergency stroke treatment under guidance by a stroke specialist has been reported to be effective. "Drip and Ship" treatment refers to initiating intravenous recombinant tissue-type plasminogen activator(rt-PA)infusion at a remote hospital(Drip)and then transporting patients to an institution capable of multimodality management and endovascular treatment of stroke(Ship). We report here a case analysis and examinations on treatment methods, prognosis, and some other parameters in 16 patients who were transported to the Stroke Care Unit(SCU)of the Tokushima University Hospital while undergoing"Drip and Ship"treatment between June 2013 and November 2015. Occluded vessels were recanalized by rt-PA administration in 5/12patients (42%). For 6 cases in which recanalization was not achieved with rt-PA, endovascular treatment was performed, and recanalization was obtained in 3 patients(50%). There was a marked improvement(8 4points on average)in NIHSS at the time of discharge compared to that before rt-PA administration. A representative case showed a 26-point improvement in NIHSS at the time of discharge compared to the pretreatment value. The advantage of"Drip and Ship"treatment is two-fold : It allows for rt-PA treatment of acute ischemic stroke patients at remote-area institutions incapable of multimodality stroke management, and also makes it possible to add endovascular treatment for rt-PA-irresponsive cases in which recanalization of occluded vessels could not be achieved with rt-PA therapy. The results suggest that the"Drip and Ship"treatment is a safe and effective means to eliminate regional disparities in intravenous rt-PA therapy and can make more contributions to the collaborative stroke care in the Tokushima prefecture in the future. (キーワード) Drip and Ship / recombinant tissue-type plasminogen activator / endovascular therapy (徳島大学機関リポジトリ) ● Metadata: 110387 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050001338911988480 (徳島大学機関リポジトリ: 110387, CiNii: 1050001338911988480)
36.	Waka Sakai, Naoko Matsui, Mitsuyo Ishida, Takahiro Furukawa, Yoshimichi Miyazaki, Koji Fujita, Ryosuke Miyamoto, Nobuaki Yamamoto, Wataru Sako, Kenta Sato, Kazuya Kondo, Yoshihiko Nishida, Takao Mitsui, Yuishin Izumi and Ryuji Kaji : Late-onset myasthenia gravis is predisposed to become generalized in the elderly, eNeurologicalSci, Vol.2, 17-20, 2016. (徳島大学機関リポジトリ) ● Metadata: 110923 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ensci.2016.02.004 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ensci.2016.02.004 (徳島大学機関リポジトリ: 110923, DOI: 10.1016/j.ensci.2016.02.004)
37.	山本伸昭, 和泉唯信, 山本雄貴, 垂髪祐樹, 梶龍兒, 里見淳一郎, 永廣信治 : ASL1, 臨床神経学, Vol.56, No.3, 225, 2016年.
38.	Nobuaki Yamamoto, Junichiro Satomi, Yamamoto Yuki, Takahiro Furukawa, Yoshiteru Tada, Masafumi Harada, Shinji Nagahiro and Ryuji Kaji : The susceptibility vessel sign containing two compositions on 3-tesla T2-weighted image and single corticosubcortical infarct on diffusion-weighted image are associated with cardioembolic stroke, Journal of the Neurological Sciences, Vol.359, No.1-2, 141-145, 2015. (要約) Although accurate diagnosis of the ischemic stroke subtype is one of the most important factors for selection of therapeutic approach, it is sometimes difficult at the time of admission. We previously reported that susceptibility vessel sign (SVS) with two layers (termed two-layered SVS) on 3-tesla-T2-weighted image (T2-WI) might be useful to predict cardioembolic stroke in patients with cerebral major vessel occlusion. We studied about biomarkers on magnetic resonance imaging (MRI), including two-layered SVS for diagnosing cardioembolic stroke. We included 132 ischemic stroke patients within 24h from onset who suffered internal carotid artery or middle cerebral artery occlusion due to cardioembolic stroke (group CE) or large artery atherosclerosis (group LAA). We studied about biomarkers on MRI such as two-layered SVS and abnormal finding patterns of diffusion-weighted image (DWI) for diagnosis of cardioembolic stroke in addition to laboratory data, physiological examination, and clinical findings. In this study, 132 patients (72 men and 60 women, age 74.5 ± 12.1 years) were included. Of these, 63 (47.7%) were cardioembolic stroke. In univariate analysis, frequency of comorbid atrial fibrillation, presence of two-layered SVS on T2-WI and that of single corticosubcortical infarct on DWI, intima-media thickness were significantly higher in group CE. In multivariate analysis, the presence of two-layered SVS and single corticosubcortical infarct were associated with cardioembolic stroke (odds ratio, two-layered SVS, 30.08, p<0.001; single corticosubcortical infarct, 15.78, p<0.001). Biomarkers associated with cardioembolic stroke may be two-layered SVS on T2-WI and single corticosubcortical infarct on DWI. (キーワード) 3-T MRI / T2-weighted image / SVS / Two-layered SVS / Diffusion-weighted image / Stroke subtype (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jns.2015.10.033 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26671103 ● Summary page in Scopus @ Elsevier: 2-s2.0-84949635529 (DOI: 10.1016/j.jns.2015.10.033, PubMed: 26671103, Elsevier: Scopus)
39.	Nobuaki Yamamoto, Junichiro Satomi, Yuishin Izumi, Yamamoto Yuki, Shinji Nagahiro and Ryuji Kaji : Predictors of a favorable outcome after recanalization in patients with cerebral major vessel occlusion, Journal of Stroke & Cerebrovascular Diseases, Vol.24, No.12, 2793-2799, 2015. (要約) Although tissue plasminogen activator and endovascular treatment were reported to be useful for recanalization in patients with major vessel occlusion (MVO), the outcome in some patients with recanalization was unfavorable. We could detect prolongation of the ipsilateral posterior cerebral artery (PCA) to the ischemic side on magnetic resonance angiography in some patients (ipsilateral-PCA sign). We investigated the predictors including radiological findings for a favorable outcome after successful recanalization. We included 76 patients with MVO of the anterior circulation and documented recanalization by treatment. We divided our patients into 2 groups: group F (modified Rankin scale [mRS] score = 0-2) and group UF (mRS score = 3-6). We compared biomarkers between the groups. National Institutes of Health Stroke Scale (NIHSS) score before treatment in group F (8.5) was lower than that in group UF (16.0; P <.001). Sensitivity of the ipsilateral-PCA sign was commonly associated with group F (67.5% versus 19.4%, P <.001), and specificity of the sign was 80.6%. Absence of infarcts in the anterior cerebral artery (ACA) territory and ACA occlusion were also associated with a favorable outcome. In multivariate analysis, the ipsilateral-PCA sign and NIHSS score (≤ 10) were independent predictors of favorable outcome (odds ratio = 9.92, 95% confidence interval [CI] 2.71-36.23, P = .001; and odds ratio = 9.15, 95% CI 2.44-34.36, P = .001, respectively) The ipsilateral-PCA sign and low NIHSS score (≤ 10) were predictors of a favorable outcome in patients with MVO and documented recanalization by treatments. (キーワード) magnetic resonance angiography / recanalization / endovascular recanalization / tissue-type plasminogen activator (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2015.08.012 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26387040 ● Summary page in Scopus @ Elsevier: 2-s2.0-84949727124 (DOI: 10.1016/j.jstrokecerebrovasdis.2015.08.012, PubMed: 26387040, Elsevier: Scopus)
40.	Nobuaki Yamamoto, Junichiro Satomi, Masafumi Harada, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji : Is the Susceptibility Vessel Sign on 3-Tesla Magnetic Resonance T2-Weighted Imaging a Useful Tool to Predict Recanalization in Intravenous Tissue Plasminogen Activator?, Clinical Neuroradiology, 2014. (要約) The aim of this study was to investigate the independent factors associated with the absence of recanalization approximately 24 h after intravenous administration of tissue-type plasminogen activator (IV TPA). The previous studies have been conducted using 1.5-Tesla (T) magnetic resonance imaging (MRI). We studied whether the characteristics of 3-T MRI findings were useful to predict outcome and recanalization after IV tPA. Patients with internal carotid artery (ICA) or middle cerebral artery (MCA) (horizontal portion, M1; Sylvian portion, M2) occlusion and treated by IV tPA were enrolled. We studied whether the presence of susceptibility vessel sign (SVS) at M1 and low clot burden score on T2-weighted imaging (T2-CBS) on 3-T MRI were associated with the absence of recanalization. A total of 49 patients were enrolled (27 men; mean age, 73.9 years). MR angiography obtained approximately 24 h after IV tPA revealed recanalization in 21 (42.9 %) patients. Independent factors associated with the absence of recanalization included ICA or proximal M1 occlusion (odds ratio, 69.6; 95 % confidence interval, 5.05-958.8, p = 0.002). In this study, an independent factor associated with the absence of recanalization may be proximal occlusion of the cerebral arteries rather than SVS in the MCA or low T2-CBS on 3-T MRI. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00062-014-0363-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25516146 ● Search Scopus @ Elsevier (PMID): 25516146 ● Search Scopus @ Elsevier (DOI): 10.1007/s00062-014-0363-x (DOI: 10.1007/s00062-014-0363-x, PubMed: 25516146)
41.	Nobuaki Yamamoto, Junichiro Satomi, Yoshiteru Tada, Masafumi Harada, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji : The two-1 layered susceptibility vessel sign on 3-tesla T2-weighted imaging is a predictive biomarker of stroke subtype, Stroke, Vol.46, No.1, 269-271, 2014. (要約) A susceptibility vessel sign (SVS) on 1.5-tesla (T)-T2-weighted images may predict cardioembolism. It has also been detected in patients with large artery atherosclerosis. In patients with major vessel occlusion, the SVS was comprised 2 layers on 3T-T2-weighted images. We assessed the efficacy of 2-layered SVS on 3T-T2-weighted imaging scans for predicting cardioembolism. Our study included 132 patients who had ischemic stroke within the preceding 24 hours and presented with internal carotid artery or middle cerebral artery occlusion because of cardioembolism or large artery atherosclerosis. We compared 2-layered SVS and SVS on 3T-T2-weighted imaging scans for their sensitivity, specificity, and diagnostic odds ratio for predicting cardioembolism. We enrolled 132 patients (72 men; mean age, 74.5 years); of these, 63 (47.7%) were presented with cardioembolism. Although the sensitivity of SVS and 2-layered SVS for cardioembolism and large artery atherosclerosis was not statistically different (74.6% and 58.0%, respectively), the sensitivity of 2-layered SVS was significantly higher in patients with cardioembolism (42.9%) than those with large artery atherosclerosis (2.9%; P<0.001). The specificity and diagnostic odds ratio for 2-layered SVS for cardioembolism were 97.1% and 25.1; for SVS they were 42.0% and 2.1, respectively. The specificity of 2-layered SVS for cardioembolism was high. It may be useful for predicting cardioembolism and for the management of patients with acute ischemic stroke. (キーワード) imaging biomarker / 3-tesla magnetic resonance imaging / T2-weighted imaging / susceptibility vessel sign / two-layered susceptibility vessel sign (出版サイトへのリンク) ● Publication site (DOI): 10.1161/STROKEAHA.114.007227 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25477219 ● Summary page in Scopus @ Elsevier: 2-s2.0-84920283485 (DOI: 10.1161/STROKEAHA.114.007227, PubMed: 25477219, Elsevier: Scopus)
42.	山本伸昭, 里見淳一郎, 寺澤由佳, 曽我部周, 中島公平, 佐藤泰仁, 板東一彦, 阿川昌仁, 浅野登, 本藤秀樹, 和泉唯信, 梶龍兒, 永廣信治 : 脳梗塞発症後早期からの抗血小板薬使用が予後に及ぼす影響の検討, 脳卒中, Vol.36, No.6, 419-424, 2014年. (出版サイトへのリンク) ● Publication site (DOI): 10.3995/jstroke.36.419 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282679616796928 ● Search Scopus @ Elsevier (DOI): 10.3995/jstroke.36.419 (DOI: 10.3995/jstroke.36.419, CiNii: 1390282679616796928)
43.	多田恵曜, 平澤元浩, 牟礼英生, 里見淳一郎, 山本伸昭, 阿部考志, 永廣信治 : T2強調画像で脊髄内に高信号を呈する病変圧迫骨折を伴い，両下肢の筋力低下で発症した80歳女性, 脳神経外科速報, Vol.24, No.11, 1208-1211, 2014年.
44.	Nobuaki Yamamoto, Yuka Terasawa, Junichiro Satomi, Sakai Waka, Masafumi Harada, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji : Predictors of neurologic deterioration in patients with small-vessel occlusion and infarcts in the territory of perforating arteries, Journal of Stroke & Cerebrovascular Diseases, Vol.23, No.8, 2151-2155, 2014. (要約) It is difficult to predict neurologic deterioration in patients with small-vessel occlusion (SVO), that is, small infarcts in the territory of cerebral perforating arteries. We reviewed 110 patients with SVO who were admitted to our hospital. We divided them into groups with (n = 32, group 1) and without deterioration (n = 78, group 2) and evaluated their medical records, risk factors, magnetic resonance imaging findings, grade of periventricular hyperintensity (PVH), maximum diameter of the infarct area, and the number of slices showing infarcts on diffusion-weighted images (DWI). Our study population consisted of 110 patients (71 males and 39 females; mean age 69.2 years): 32 (29%) did and 78 (71%) did not suffer deterioration. By univariate analysis, the age, current smoking, history of stroke, maximum diameter of the infarcted area, number of DWI slices with infarcts, frequency of PVH, and PVH grade based on Fazekas classification differed significantly between the 2 groups. By multivariate analysis, conventional risk factors other than PVH and history of stroke were not associated with neurologic deterioration (PVH grade ≥ 2 versus PVH grade ≤ 1, odds ratio 6.72, P = .006; with stroke versus without stroke, odds ratio .21, P = .049). We also found that higher the PVH grade, the worse the National Institutes of Health Stroke Scale score at the time of discharge. PVH and without history of stroke are independently associated with neurologic deterioration in patients with SVO. (キーワード) Aged / Aged, 80 and over / Brain Infarction / Cerebral Arteries / Cerebral Ventricles / Diffusion Magnetic Resonance Imaging / Female / Humans / Intracranial Thrombosis / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Middle Aged / Odds Ratio / Predictive Value of Tests / Risk Factors / 喫煙 (smoking) / PVH grade / neurologic deterioration / predictors / small vessel occlusion (徳島大学機関リポジトリ) ● Metadata: 106332 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2014.04.011 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25088163 ● Summary page in Scopus @ Elsevier: 2-s2.0-84908209055 (徳島大学機関リポジトリ: 106332, DOI: 10.1016/j.jstrokecerebrovasdis.2014.04.011, PubMed: 25088163, Elsevier: Scopus)
45.	Yoshiteru Tada, Junichiro Satomi, Takashi Abe, Kazuyuki Kuwayama, Shu Sogabe, Koji Fujita, Nobuaki Yamamoto, Ryuji Kaji, Masafumi Harada and Shinji Nagahiro : Intra-arterial signal on arterial spin labeling perfusion MRI to identify the presence of acute middle cerebral artery occlusion, Cerebrovascular Diseases, Vol.38, No.3, 191-196, 2014. (要約) The susceptibility vessel sign on gradient echo-type-T2-weighted imaging is a well-known marker of arterial occlusion. Stagnant flow in front of the middle cerebral artery (MCA) occlusion sites may contribute to the intra-arterial, high-intensity signal on arterial spin labeling magnetic resonance imaging (MRI), making it another potential marker of MCA occlusion. We compared the intra-arterial, high-intensity signal and susceptibility vessel sign in patients with symptomatic MCA occlusion and patients without major vessel occlusion. We identified transient ischemic attack or ischemic stroke patients with (1) 3-T MRI performed within 24 h after clinical onset including arterial spin labeling, T2-weighted imaging, and magnetic resonance angiography (MRA) and (2) either having MCA occlusion (n = 34 patients) or without major vessel occlusion (n = 24 patients). The intra-arterial, high-intensity signal was defined as an enlarged circular or linear bright hyperintensity within the artery. The susceptibility vessel sign was defined as an enlarged spot of hypointensity within the MCA, in which the diameter of the hypointense signal within the vessel exceeded the contralateral vessel diameter. The presence or absence of the intra-arterial, high-intensity signal and susceptibility vessel sign were assessed, along with their inter-rater agreement and consistency with the presence of MCA occlusion on MRA. The intra-arterial, high-intensity signal was detectable in 30 patients (52%), and susceptibility vessel sign was observed in 17 patients (29%). The sensitivity of the intra-arterial high-intensity signal was significantly higher than that of the susceptibility vessel sign (88% vs. 50%; p < 0.05). The accuracy of the intra-arterial high-intensity signal was also higher than that of the susceptibility vessel sign (93% vs. 71%; p < 0.05). The intra-arterial high-intensity signal was situated in the proximal regions of the susceptibility vessel sign on T2*WI within the MCA. Neither the intra-arterial high-intensity signal nor the susceptibility vessel sign was observed in patients without major vessel occlusion. Inter-rater agreement was good for intra-arterial high-intensity signal detection (κ = 0.73) and moderate for susceptibility vessel sign detection (κ = 0.47). The presence or absence of the intra-arterial high-intensity signal was highly consistent with that of MCA occlusion on MRA (κ = 0.74). The intra-arterial high-intensity signal on arterial spin labeling appears to be useful to identify the presence of acute MCA occlusion and may be associated with stagnant flow in front of occlusion sites. The intra-arterial high-intensity signal may also be used to identify the occlusion site. (キーワード) Aged / Aged, 80 and over / Cerebral Angiography / Female / Humans / Infarction, Middle Cerebral Artery / Ischemic Attack, Transient / Magnetic Resonance Angiography / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Middle Aged / Middle Cerebral Artery / Sensitivity and Specificity / Stroke (出版サイトへのリンク) ● Publication site (DOI): 10.1159/000365653 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25300901 ● Summary page in Scopus @ Elsevier: 2-s2.0-84912121647 (DOI: 10.1159/000365653, PubMed: 25300901, Elsevier: Scopus)
46.	Nobuaki Yamamoto, Yuka Terasawa, Junichiro Satomi, Ryoma Morigaki, Koji Fujita, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji : Reversibility of ischemic findings on 3-tesla magnetic resonance T2()-weighted image after recanalization, The Journal of Medical Investigation : JMI, Vol.61, No.1,2, 190-196, 2014. (要約) Ischemic vessel signs (IVS) can be detected on 3-tesla T2()-weighted magnetic resonance images as a vessel enlargement at the territory of acute ischemia caused by major vessel occlusion or stenosis. Here, we studied changes in IVS before and after recanalization by the administration of intravenous recombinant tissue plasminogen activator (IV rtPA), carotid artery stenting or percutaneous transluminal angioplasty in patients with major vessel occlusion or stenosis. We performed magnetic resonance imaging for all patients treated by IV rtPA at the time of admission, shortly after and 24-72 hours after treatment with IV rtPA. We reviewed the IVS to assess its natural course of IVS by assessing patients who did not recanalize. IVS tended to disappear after recanalization. Conversely, in patients without recanalization, IVS did not disappear shortly after IV rtPA; rather, it disappeared 24-72 hours after IV rtPA, especially in the presence of complete infarction. Recanalization by IV rtPA or endovascular treatment contributed to improved clinical deficits or the prevention from further progression. IVS can be a parameter of misery perfusion and an important factor to detect the patients who have an indication of treatment for recanalization. (キーワード) Administration, Intravenous / Aged / Aged, 80 and over / Angioplasty / Carotid Arteries / Carotid Stenosis / Diffusion Magnetic Resonance Imaging / Disease Progression / Female / Humans / 虚血 (ischemia) / Male / Middle Aged / Retrospective Studies / Stents / Time Factors / Tissue Plasminogen Activator / Treatment Outcome (徳島大学機関リポジトリ) ● Metadata: 109553 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.61.190 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24705765 ● Summary page in Scopus @ Elsevier: 2-s2.0-84897951917 (徳島大学機関リポジトリ: 109553, DOI: 10.2152/jmi.61.190, PubMed: 24705765, Elsevier: Scopus)
47.	里見淳一郎, 多田恵曜, 八木謙次, 松下展久, 山本伸昭, 兼松康久, 永廣信治 : 80歳以上の破裂脳動脈瘤の治療成績, 脳卒中の外科, Vol.42, No.1, 42-46, 2014年. (要約) While the number of elderly patients who presented with aneurysmal subarachnoid hemorrhage (SAH) has been increasing, its optimal management in that population remains controversial. Therefore, we retrospectively reviewed the treatment outcomes in 49 consecutive patients aged between 80 and 94 years who presented with SAH. The neurological World Federation of Neurological Surgeons (WFNS) grade at the time of admission was Grade I in 7, Grade II in 11, Grade III in 8, Grade IV in 13, and Grade V in 10 patients. Of the 49 patients, 28 underwent coil embolization, and 7 (25%) had a favorable outcome (mRS: 0-2) at discharge, while in 21 (75%) the outcome was poor (mRS: 3-6). Six patients underwent clipping; the outcome was favorable in one patient (17%) and poor in 5 (83%). Of 15 patients under conservative therapy none had a favorable outcome. A low WFNS grade (I-II) was significantly associated with a favorable outcome (p<0.05). Although the treatment outcome in elderly patients with SAH was poor, radical treatment of ruptured aneurysms should be considered if their WFNS grade is low. (キーワード) ruptured aneurysm / elderly patients / outcome (出版サイトへのリンク) ● Publication site (DOI): 10.2335/scs.42.42 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204673719808 ● Search Scopus @ Elsevier (DOI): 10.2335/scs.42.42 (DOI: 10.2335/scs.42.42, CiNii: 1390001204673719808)
48.	Yuka Terasawa, Nobuaki Yamamoto, Ryoma Morigaki, Koji Fujita, Yuishin Izumi, Junichiro Satomi, Masafumi Harada, Shinji Nagahiro and Ryuji Kaji : Brush sign on 3-T t2-weighted MRI as a potential predictor of hemorrhagic transformation after tissue plasminogen activator therapy, Stroke, Vol.45, No.1, 274-276, 2014. (要約) The brush sign (BS) is the enlargement of medullary veins on 3-T T2-weighted MRI seen in patients with ischemic stroke because of major cerebral artery occlusion. However, the clinical relevance of BS in patients with acute stroke remains unclear. We assessed the correlation between detecting BS with the development of hemorrhagic transformation after intravenous thrombolysis. We enrolled consecutive patients with M1 or M2 occlusion treated with intravenous tissue plasminogen activator. We classified the patients into 2 groups: the group positive for BS (P-BS) and the group negative for BS (N-BS). We investigated the differences in MRI findings and the clinical outcome between the 2 groups. The subjects consisted of 36 patients (19 men; mean age, 74.7 years). Twenty-one patients (58%) had M1 occlusion, and 15 (42%) had M2 occlusion. Twenty-five patients (69%) were classified into the P-BS group and 11 (31%) into the N-BS group. Recanalization was observed in 15 (60%) and 10 (90%) patients in the P-BS and N-BS groups, respectively (P=0.116). Hemorrhagic transformation on MRI was observed more frequently in the P-BS group than in the N-BS group (64% versus 18%; P=0.027). A good outcome (mRS, 0-1) at discharge was found in 24% of patients in the P-BS group and in 45% of patients in the N-BS group (P=0.152). A multivariate logistic regression analysis revealed that the presence of BS (odds ratio, 9.08; 95% confidence interval, 1.4-59.8; P=0.022) was independently associated with hemorrhagic transformation. BS may predict the development of hemorrhagic transformation in patients with acute stroke treated with intravenous tissue plasminogen activator. (キーワード) Aged / Aged, 80 and over / Cerebral Hemorrhage / Disease Progression / Female / Fibrinolytic Agents / Humans / Image Processing, Computer-Assisted / Intracranial Embolism / Magnetic Resonance Imaging / Male / Middle Aged / Prognosis / Prospective Studies / Stroke / Thrombolytic Therapy / Tissue Plasminogen Activator / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1161/STROKEAHA.113.002640 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24172577 ● Summary page in Scopus @ Elsevier: 2-s2.0-85027928664 (DOI: 10.1161/STROKEAHA.113.002640, PubMed: 24172577, Elsevier: Scopus)

学術論文(紀要・その他):

1.	Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Nobuaki Yamamoto, Masaaki Korai, Kazuhisa Miyake, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, Yuki Yamamoto, Kazutaka KURODA and Yasushi Takagi : Evaluation of Serial Intra-Arterial Indocyanine Green Videoangiography in the Surgical Treatment of Cranial and Craniocervical Junction Arteriovenous Fistulae: A Case Series, Operative Neurosurgery, Vol.25, No.3, 292-300, 2023. (要約) Intravenous indocyanine green (IV-ICG) videoangiography is commonly performed to detect blood flow in the microscopic view. However, intra-arterial ICG (IA-ICG) videoangiography provides high-contrast imaging, repeatability within a short period of time, and clear-cut separation of the arterial and venous phases compared with IV-ICG. These features are useful for detecting retrograde venous drainage (RVD) and shunt occlusion in arteriovenous fistulae (AVF) surgery. This study aimed to investigate whether IA-ICG videoangiography can be repeatable within a short period of time and be useful for detecting RVD and shunt occlusion in cranial- and craniocervical junction (CCJ)-AVF surgery. Between January 2012 and December 2022, 50 patients were treated with endovascular or surgical intervention for cranial- and CCJ-AVF at Tokushima University Hospital. Of these, 5 patients (6 lesions) underwent open surgery with IA-ICG videoangiography in a hybrid operating room. We analyzed the data of these 5 patients (6 lesions). There were 4/patient (median, range 2-12) and 3.5/lesion (median, range 2-10) intraoperative IA-ICG runs. IA-ICG videoangiography detected RVD in all patients. Clearance of IA-ICG-induced fluorescence was achieved within 30 seconds in all patients at each region of interest. After the disconnection of the fistulae, IA-ICG videoangiography and intraoperative digital subtraction angiography (DSA) confirmed the disappearance of RVD in all patients. There were no complications associated with IA-ICG videoangiography. This study showed that IA-ICG videoangiography is repeatable within a short period of time before and after obliteration and can be useful for detecting RVD and shunt occlusion in cranial- and CCJ-AVF surgery. IA-ICG videoangiography also allows intraoperative DSA studies in a hybrid operating room. Considering the recent advancements in hybrid operating rooms, combining IA-ICG videoangiography with intraoperative DSA is a useful strategy for cranial- and CCJ-AVF surgery. (キーワード) Humans / Indocyanine Green / Coloring Agents / Neurosurgical Procedures / Vascular Surgical Procedures / Arteries (出版サイトへのリンク) ● Publication site (DOI): 10.1227/ons.0000000000000796 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37345942 ● Summary page in Scopus @ Elsevier: 2-s2.0-85168222953 (DOI: 10.1227/ons.0000000000000796, PubMed: 37345942, Elsevier: Scopus)
2.	桑山一行, 西京子, 里見淳一郎, 山本伸昭, 永廣信治 : 徳島大学病院脳卒中センターでの内頚動脈急性閉塞に対する治療戦略, 四国医学雑誌, Vol.70, No.5,6, 167-172, 2014年. (要約) Objective : Strokes related to acute internal carotid artery (ICA) occlusion are associated with extremely poor prognosis. Recently, some studies have reported that the prognosis has been getting better by treating with intra-arterial endovascular therapy. We sought to evaluate clinical outcomes in patients with acute ischemic stroke attributable to ICA occlusion treated with intraarterial endovascular therapy or otherwise. Methods : We reviewed 44 patients who underwent treatment with intra-arterial endovascular therapy or otherwise in our stroke care unit (SCU) from January, 2011 to May, 2014. We compared the prognosis of patients in the 2 treatment groups (endovascular group, n＝23 vs nonendovascular group, n＝21). Results : The rate of good prognosis (modified Rankin Score of ≦2) was significantly higher in the endovascular group than non-endovascular group (17．4% vs0%，p＝0．045). The rate of patients who had extreme improvements of National Institutes of Health Stroke Scale (NIHSS) ≧8 was higher in the endovascular group than non-endovascular group (30．4% vs14．3%). Concerning the improvement of NIHSS ≧8, recombinant tissue-type plasminogen activator (rt-PA) or the left side ICA occlusion were associated significantly (p＝0．019, p＝0．042, respectively). Although the hypothesis that endovascular therapy could contribute to extreme improvements of NIHSS wasn't proved (p＝0．202), there was one case that NIHSS was dramatically improved from 22 to 0 by endovascular therapy. Conclusions : Intra-arterial endovascular therapy of ICA occlusion might result in improved clinical outcomes for indicated cases. (キーワード) ICA occlusion / intra-arterial endovascular therapy / recombinant tissue-type plasminogen activator (rt-PA) (徳島大学機関リポジトリ) ● Metadata: 109899 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050564287418449536 (徳島大学機関リポジトリ: 109899, CiNii: 1050564287418449536)
3.	桑山一行, 西京子, 里見淳一郎, 山本伸昭, 永廣信治 : 徳島大学病院脳卒中センターでの内頚動脈急性閉塞に対する治療戦略, 第249回徳島医学会学術集会, 2014年.

総説・解説:

1.	藤田浩司, 山本雄貴, 山本伸昭 : 放射線科医が知っておくべき脳血管障害診療 update】特殊な脳血管障害の診断 CADASIL,CARASIL, 悪性腫瘍に伴う脳梗塞,血管炎,脳アミロイド血管症, 臨床画像, Vol.36, 92-103, 2020年4月. (出版サイトへのリンク) ● Publication site (DOI): 10.18885/ci.0000000269 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390572174450972800 ● Search Scopus @ Elsevier (DOI): 10.18885/ci.0000000269 (DOI: 10.18885/ci.0000000269, CiNii: 1390572174450972800)
2.	和泉唯信, 山本伸昭 : 【健康長寿を目指して】脳卒中，認知症にならないために, 四国医学雑誌, Vol.75, No.1-2, 17-22, 2019年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050845763430357504 (CiNii: 1050845763430357504)

国際会議:

1.	Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi : Cranial geometry in patients with dystonia, The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023.
2.	NAKANISHI Hiroshi, Ryoma Morigaki, Nobuaki Yamamoto, Joji Fujikawa, Teruo Oda, OMAE Hiroshi, Yuishin Izumi and Yasushi Takagi : The effect of Rikaba, a hybrid physical exercise salon for Parkinson's disease patients, The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023.
3.	Harumi Kadota, Shoma Fujisawa, Masaki Oono, Ryoma Morigaki, Nobuaki Yamamoto, Yasuhisa Kanematsu, Manabu Ishihara and Masami Shishibori : Development of a 3D visualization system for the cerebral aneurysm coil embolization, Proceedings Volume 11794, Fifteenth International Conference on Quality Control by Artificial Vision; 117940C (2021), Tokushima, Jul. 2021. (出版サイトへのリンク) ● Publication site (DOI): 10.1117/12.2589084 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1117/12.2589084 (DOI: 10.1117/12.2589084)
4.	Yoshiteru Tada, Toshitaka Fujihara, Kenji Shimada, Nobuaki Yamamoto, Hiroki Yamazaki, Yuishin Izumi, Masafumi Harada, Yasuhisa Kanematsu and Yasushi Takagi : Peri-ictal normal arterial spin labeling imaging in patients with seizures, 13 回アジア・オセアニアてんかん学会(13th AOEC), Jun. 2021.
5.	Yuki Yamamoto, Nobuaki Yamamoto, K Kuroda, Yasuhisa Kanematsu, Masaaki Korai, Kenji Shimada, Yuishin Izumi and Yasushi Takagi : High White Blood Cell Count is a Risk Factor for Contrast-Induced Nephropathy following Mechanical Thrombectomy, The 5th European Stroke Organization Conference, ESOC 2019, Milan, May 2019.
6.	Nobuaki Yamamoto, Yuki Yamamoto, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yuishin Izumi, Yasushi Takagi and Ryuji Kaji : Hyperintense Signals on Arterial Spin-Labeled Imaging as a predictor for favorable outcome after Late Time Window Thrombectomy, The 5th European Stroke Organization Conference, ESOC 2019, Milan, May 2019.
7.	Masaaki Korai, Yasuhisa Kanematsu, Idumi Yamaguchi, Nobuaki Yamamoto, Yuki Yamamoto, Junichiro Satomi and Yasushi Takagi : Treatment strategy and outcom of ruptured vertebral artry dissecting aneurysms, World Live Neurovascular Conference 2018, 神戸市, Apr. 2018.
8.	Yuki Yamamoto, Nobuaki Yamamoto, Idumi Yamaguchi, Masaaki Korai, Yasuhisa Kanematsu, Junichiro Satomi, Shinji Nagahiro and Ryuji Kaji : Crab claw sign predicts successful recanalization in acute mechanical thrombectomy, 14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY, Budapest, Oct. 2017.
9.	Masaaki Korai, Yasuhisa Kanematsu, Yoshiteru Tada, Idumi Yamaguchi, Nobuaki Yamamoto, Yuki Yamamoto and Junichiro Satomi : Treatment strategy and outcome of ruptured vertebral artery dissecting aneurysms, 14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY, Budapest, Oct. 2017.
10.	Junichiro Satomi, Yasuhisa Kanematsu, Masaaki Korai, Yuki Yamamoto, Nobuaki Yamamoto, Yoshifumi Mizobuchi, Hideo Mure, Yoshiteru Tada, Kohhei Nakajima, Toshiyuki Okazaki and Toshitaka Fujihara : Acute stroke management using image sharing on smart phones and tablet devices, 14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY, Budapest, Oct. 2017.
11.	Nobuaki Yamamoto, Junichiro Satomi, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji : Usefulness of 3-tesla magnetic resonance arterial spin-labeled imaging for diagnosis of cranial dural arteriovenous fistula, European Stroke Organization Conference, May 2017.
12.	Nobuaki Yamamoto, Junichiro Satomi, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji : Predictors of a favorable outcome after recanalization In patients with cerebral major vessel occlusion, International Symposium on Thrombectomy and Acute Stroke Therapy, Oct. 2016.
13.	Nobuaki Yamamoto, Junichiro Satomi, Shinji Nagahiro and Ryuji Kaji : Predictors of a good outcome after successful recanalization using tPA and endovascular treatment in patients with cerebral major vessel occlusion, 25th European Stroke Conference, Venice, Apr. 2016.
14.	Nobuaki Yamamoto, Junichiro Satomi, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji : Is the susceptibility vessel sign on 3-tesla magnetic resonance T2*-weighted imaging a useful tool to predict recanalization?, European Stroke Conference 2015, Vienna, Austria, May 2015.
15.	Junichiro Satomi, Yoshiteru Tada, Takashi Abe, Kazuyuki Kuwayama, Ryuji Kaji, Nobuaki Yamamoto, Masafumi Harada and Shinji Nagahiro : Intra-arterial signal on arterial spin labeling perfusion MRI can identify stagnant flow in patients with acute middle cerebral rtery occlusion, INTERNATIONAL STROKE CONFERENCE 2015, Nashville, USA, Feb. 2015.
16.	永廣信治, 桑山一行, 里見淳一郎, 山本伸昭, 曽我部周 : くも膜下出血で発症した多発脳動脈瘤の1例, 第23回NPO法人日本脳神経血管内治療学会中国四国地方会, Hiroshima, Japan, 2014年9月.
17.	Nobuaki Yamamoto, Yuka Terasawa, Junichiro Satomi, Ryoma Morigaki, Koji Fujita, Masafumi Harada, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji : Reversibility of ischemic findings on 3-tesla magnetic resonance T2*-weighted image after recanalization, European Stroke Conference 2014, Nice, France, May 2014.

国内講演発表:

1.	島田健司, 山口泉, 宮本健志, 曽我部周, 高麗雅章, 山本伸昭, 花岡真美, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 : 骨内シャントの有無による海綿静脈洞部硬膜動静脈瘻の臨床的特徴の違いについて, 2023年11月.
2.	兼松康久, 羽星辰哉, 山口泉, 石原学, 曽我部周, 高麗雅章, 島田健司, 黒田一駿, 山本伸昭, 髙木康志 : ICT, 2023年11月.
3.	島田健司, 山口泉, 宮本健志, 曽我部周, 高麗雅章, 山本伸昭, 花岡真実, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 : 骨内シャントの有無による海綿静脈洞部硬膜動静脈瘻の臨床的特徴の違いについて, 日本脳神経外科学会第82回学術集会, 2023年10月.
4.	曽我部周, 兼松康久, 山口泉, 山本伸昭, 島田健司, 髙木康志 : もやもや病に合併した頭蓋内内頚動脈閉塞に対して再開通療法をおこなった1例, 脳血管内治療ブラッシュアップセミナー2023, 2023年7月.
5.	山本伸昭, 黒田一駿, 山本雄貴, 和泉唯信, 曽我部周, 高麗雅章, 島田健司, 兼松康久, 髙木康志 : First pass TICI2B患者の追加治療における意義, 第64回日本神経学会学術大会, 2023年5月.
6.	山本雄貴, 山本伸昭, 黒田一駿, 松田知大, 島田健司, 兼松康久, 髙木康志, 和泉唯信 : 頸動脈浮遊血栓に対する，ステントトリーバーによる血栓回収とCASの併用, 第64回日本神経学会学術大会, 2023年5月.
7.	高麗雅章, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 石原学, 山口泉, 山本雄貴, 黒田一駿, 髙木康志 : 当院での急性期脳底動脈閉塞に対する血管内治療成績, 第48回日本脳卒中学会学術集会, 2023年3月.
8.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本伸昭, 山本雄貴, 和泉唯信, 髙木康志 : 徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, STROKE2023, 2023年3月.
9.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 髙木康志 : 当院での低ASPECTS症例の拡散強調画像に対するRAPIDを用いた後方視的定量評価, 第48回日本脳卒中学会学術集会, 2023年3月.
10.	黒田一駿, 山本雄貴, 山本伸昭, 松田知大, 板東康司, 山口泉, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 広範囲シャントを伴った横静脈洞部硬膜動静脈瘻に対して血管内治療を行った1例, 第112回日本神経学会中国・四国地方会, 2022年12月.
11.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 和泉唯信, 髙木康志 : 当院の主幹動脈閉塞低ASPECT症例の拡散強調画像に対するRAPIDでの後方視的定量評価, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
12.	山本雄貴, 兼松康久, 山本伸昭, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志, 和泉唯信 : 地方都市における救急医療連携アプリケーションを用いたLVO診断スケールの活用, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
13.	山本伸昭, 黒田一駿, 山本雄貴, 山口泉, 曽我部周, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 病院前スケール，iSchemaView RAPID導入前後の比較検討, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
14.	山本伸昭, 山本雄貴, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 兼松康久, 髙木康志, 和泉唯信 : 9Fr long sheathを用いた巨大血栓によるLVO治療例, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
15.	高麗雅章, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 石原学, 山口泉, 山本雄貴, 黒田一駿, 髙木康志 : 当院での急性期脳底動脈閉塞に対する血管内治療成績, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
16.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 髙木康志 : 当院での主幹動脈閉塞-低ASPECT症例の拡散強調画像に対するRAPIDを用いた後方視的定量評価, 日本脳神経外科学会第81回学術総会, 2022年9月.
17.	兼松康久, 山口泉, 石原学, 曽我部周, 高麗雅章, 多田恵曜, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 佐藤健太, 島谷佳光, 亘雄也, 田村哲也, 新野清人, 髙木康志 : 徳島県総合メディカルゾーンでの急性期脳卒中診療の取り組み, 日本脳神経外科学会第81回学術総会, 2022年9月.
18.	山本雄貴, 兼松康久, 山本伸昭, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志, 和泉唯信 : 徳島市におけるアプリケーションを用いたLVO診断スケールの活用(FAST-ED Tokushima), 第24回中国四国脳卒中研究会, 2022年9月.
19.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, 徳島医学会学術集会, 2022年7月.
20.	山本雄貴, 山本伸昭, 兼松康久, 黒田一駿, 藤田浩司, 髙木康志, 和泉唯信 : 徳島市におけるアプリケーションを用いた病院前脳主幹動脈閉塞診断スケールの活用, 第63回日本神経学会学術大会, 2022年5月.
21.	山本伸昭, 黒田一駿, 山本雄貴, 兼松康久, 森垣龍馬, 和泉唯信, 髙木康志 : 脳主幹動脈閉塞に対する血行再建術において有効再開通が得られた患者の予後関連因子, 第63回日本神経学会学術大会, 2022年5月.
22.	曽我部周, 兼松康久, 山口泉, 四方英二, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 : open-cell stentにclosed-cell stentをオーバーラップさせたCASの治療成績, STROKE2022, 2022年3月.
23.	森垣龍馬, 藤川丈自, 松田拓, 三宅一央, 牟礼英生, 小田輝王, 宮本亮介, 藤田浩司, 山本伸昭, 和泉唯心, 髙木康志 : 特発性ジストニア患者の頭蓋骨の歪み, 日本定位・機能神経外科学会機関紙, 2022年1月.
24.	山口泉, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 宮本健志, 石原学, 山本雄貴, 髙木康志 : 開頭下にLabbe静脈を直線穿刺することで治療し得たTSS d-AVFの1例, 近畿脳神経血管内手術法ワークショップ, 2022年1月.
25.	山口泉, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 宮本健志, 石原学, 山本雄貴, 髙木康志 : 開頭下にLabbe静脈の直線穿刺によるTVEを行ったTSS d-AVFの1例, 第92回日本脳神経外科学会中国四国支部会, 2021年12月.
26.	曽我部周, 兼松康久, 山口泉, 四方英二, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 : 一期的にopen-cell stentにclosed-cell stentを重ねたCASの初期治療成績, 日本脳神経血管内治療学会, 2021年11月.
27.	宮本健志, 曽我部周, 兼松康久, 四方英二, 山口泉, 石原学, 島田健司, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 脳主幹動脈閉塞に対して急性期再開通療法後MRIのRibbon signの特徴, 日本脳神経血管内治療学会, 2021年11月.
28.	石原学, 兼松康久, 中西信人, 森垣龍馬, 山本伸昭, 大藤純, 獅々堀正幹, 髙木康志 : 日本ICU患者データベース(JIPAD)による急性期脳卒中症例の検討機械学習(データマイニング)を用いた解析, 日本脳神経外科学会学術総会, 2021年10月.
29.	森垣龍馬, 藤川丈自, 小田輝王, 中西浩, 山本伸昭, 三宅一央, 松田拓, 髙木康志 : 機械学習を用いた脳線条体免疫染色画像の解析, 日本脳神経外科学会学術総会, 2021年10月.
30.	兼松康久, 金澤裕樹, 島田健司, 曽我部周, 宮本健志, 石原学, 四方英二, 山口泉, 多田恵曜, 山本雄貴, 山本伸昭, 原田雅史, 髙木康志 : CEST MRIを用いた頚動脈プラーク診断 Chemical exchange saturation transfer MRI for carotid plaque imaging, NMC Case Report Journal, 2021年10月.
31.	曽我部周, 兼松康久, 山口泉, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 : 当院でのopen-cell stentとclosed-cell stentの2枚重ねでのCASの治療成績, NMC Case Report Journal, 2021年10月.
32.	山口泉, 兼松康久, 島田健司, 山本伸昭, 宮本健志, 曽我部周, 石原学, 山本雄貴, 髙木康志 : 硬膜動静脈瘻の診断におけるArterial spin-labelingの有用性の検討 Usefulness of Arterial Spin-Labeling for diagnosis of dural arteriovenous fistulae, 日本脳神経外科学会第80回学術総会, 2021年10月.
33.	山本伸昭, 山本雄貴, 黒田一駿, 山口泉, 曽我部周, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 脳主幹動脈閉塞における有効再開通が得られた患者における予後関連因子, 第23回中国四国脳卒中研究会, 2021年9月.
34.	大崎裕亮, 島かさ音, 山本伸昭, 山﨑博輝, 佐藤健太, 和泉唯信 : 非対称性ニューロパチー様の臨床像で発症した抗Hu抗体陽性脳脊髄炎の一例, 第32回日本末梢神経学会学術集会, 2021年9月.
35.	山本雄貴, 山本伸昭, 黒田一駿, 山口泉, 宮本健志, 島田健司, 髙木康志, 和泉唯信 : 血栓回収療法におけるFirst Pass Effect達成を予測する画像因子の探索, 第62回日本神経学会学術大会, 2021年5月.
36.	山本雄貴, 山本伸昭, 和泉唯信 : 血栓回収療法における血栓突出サインはFirst Pass Effect達成と関連する, 第46回日本脳卒中学会学術集会, 2021年3月.
37.	兼松康久, 島田健司, 曽我部周, 宮本健志, 石原学, 山口泉, 山本雄貴, 山本伸昭, 髙木康志 : 当施設における巨大血栓化脳動脈瘤に対する治療成績, 第46回日本脳卒中学会学術集会, 2021年3月.
38.	宮本健志, 曽我部周, 兼松康久, 島田健司, 山口泉, 山本伸昭, 山本雄貴, 和泉唯信, 髙木康志 : 脳梗塞急性期再開通療法後MRIの急性期ribbon signの特徴, 第46回日本脳卒中学会学術集会, 2021年3月.
39.	石原学, 中西信人, 兼松康久, 森垣龍馬, 山本伸昭, 髙木康志, 大藤純 : 日本ICU患者データベース(JIPAD)による急性期脳卒中症例の検討, 日本集中治療医学会雑誌, 2021年2月.
40.	高原実香, 山本伸昭, 宮本亮介, 藤田浩司, 和泉唯信, 住谷龍平, 中村信元, 安倍正博, 島津秀紀, 西田善彦 : 意識障害，高アンモニア血症を呈した78歳男性, 四国医学雑誌, Vol.76, No.5-6, 346, 2020年12月. (キーワード) Dexamethasone(治療的利用) / 意識障害(病因) / 腫瘍多剤併用療法 / 骨髄腫-多発性(合併症,病理学,薬物療法) / 高アンモニア血症(病因,診断) / Bortezomib(治療的利用) / BD Protocol (Bortezomib-Dexamethasone) / ヒト / 高齢者(65~79) / 男
41.	石原学, 竹村星哉, 兼松康久, 森垣龍馬, 山本伸昭, 大藤純, 大野将樹, 獅々堀正幹, 髙木康志 : 機械的学習を用いた医療データの解析脳出血症例の検討, 第79回日本脳神経外科学会学術総会, 2020年10月.
42.	高原実香, 福本竜也, 垂髪祐樹, 山本伸昭, 宮本亮介, 藤田浩司, 和泉唯信 : 長い精神病期と，広範な大脳白質病変を呈した抗NMDA受容体脳炎の35歳男性, 第61回日本神経学会学術大会, 2020年8月.
43.	島かさ音, 種井善一, 高原実香, 村上永尚, 山本伸昭, 坂東良美, 松原知康, 村山繁雄, 和泉唯信 : 腎移植から27年後に発症した延髄原発リンパ増殖性疾患の一例, 第61回日本神経学会学術大会, 2020年8月.
44.	柿原紋太, 野崎夏江, 兼本ひろみ, 津田恵, 山本恭代, 山本雄貴, 山本伸昭, 石原学, 島田健司, 兼松康久, 西京子, 加藤真介, 髙木康志 : 徳島大学病院脳卒中センター(SCU)における排尿ケアチーム介入後の下部尿路機能障害の現状, 第45回日本脳卒中学会総会(web開催), 2020年8月.
45.	石原学, 兼松康久, 山本伸昭, 曽我部周, 宮本健志, 島田健司, 山本雄貴, 大藤純, 髙木康志 : NIHSS5点以下軽症脳主幹動脈閉塞症例における転帰, 第25回日本脳神経外科救急学会, 2020年2月.
46.	山本雄貴, 山本伸昭, 兼松康久, 石原学, 宮本健志, 高麗雅章, 島田健司, 牟礼英生, 髙木康志, 和泉唯信 : 転倒後の脳脊髄液減少症に上矢状静脈洞血栓症を合併し, 血管内治療をおこなった一例, 第35回日本脳神経血管内治療学会学術総会, 2019年11月.
47.	兼松康久, 島田健司, 高麗雅章, 宮本健志, 多田恵曜, 山本雄貴, 山本伸昭, 里見淳一郎, 髙木康志 : 当院での急性期脳底動脈閉塞に対する血管内治療成績, 第35回日本脳神経血管内治療学会学術総会, 2019年11月.
48.	山本雄貴, 山本伸昭, 福本竜也, 村上永久, 宮本亮介, 藤田浩司, 牟礼英生, 兼松康久, 髙木康志, 和泉唯信 : 転倒を契機に脳脊髄液減少症と静脈洞血栓症を合併し，ブラッドパッチにて治療した脊髄小脳変性症6型の1例, 第37回日本神経治療学会学術集会, 2019年11月.
49.	石原学, 兼松康久, 山本伸昭, 宮本健志, 高麗雅章, 島田健司, 山本雄貴, 大藤純, 髙木康志 : NIHSS 5点以下の軽症脳主幹動脈閉塞症例における予後因子, 日本脳神経外科学会第78回学術集会, 2019年10月.
50.	山口泉, 兼松康久, 島田健司, 高麗雅章, 宮本健志, 北里慶子, 山本伸昭, 山本雄貴, 髙木康志 : 院内発症脳梗塞の転帰不良に関連する因子の検討, Neurologia Medico-Chirurgica, 2019年10月.
51.	山本伸昭, 山本雄貴, 石原学, 宮本健志, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 血行再建術前における経静脈的造影剤投与によるFlat panel CTAの有用性, 中四国脳卒中研究会, 2019年9月.
52.	山本伸昭, 黒田一駿, 山本雄貴, 石原学, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : Tandem Occlusion患者に対する血管内治療(Simultaneous Approach), 第44回日本脳卒中学会学術集会, 2019年3月.
53.	山本雄貴, 山本伸昭, 黒田一駿, 高麗雅章, 岡﨑敏之, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 血栓回収療法後の造影剤腎症は白血球数高値と関連する, 第44回日本脳卒中学会学術集会, 2019年3月.
54.	筑後桃子, 西麻希, 菊井聡子, 松村晃子, 兼本ひろみ, 岩野朝香, 高野栄之, 佐藤紀, 加藤真介, 西京子, 山本伸昭, 兼松康久, 髙木康志, 濵田康弘 : 当院脳卒中センター(SCU)入院患者における栄養管理―栄養サポートチーム(NST)の取り組み―, 日本脳卒中学会2019, 2019年3月.
55.	西京子, 兼松康久, 高麗雅章, 岡﨑敏之, 島田健司, 山本伸昭, 高野栄之, 加藤真介, 髙木康志 : 徳島大学病院脳卒中センター (SCU)の多職種連携による医療人育成, 日本脳卒中学会2019, 2019年3月.
56.	山本雄貴, 山本伸昭, 黒田一駿, 福本竜也, 石原学, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 治療後に症状増悪した上矢状静脈洞血栓症の一例, 第8回脳血管内治療四国遍路塾, 2019年3月.
57.	山本雄貴, 黒田一駿, 山本伸昭, 鹿草宏, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 頭癌治療中に内頚動脈閉塞を認めた1例, 第21回徳島脳血管障害カンファレンス, 2019年3月.
58.	山本雄貴, 山本伸昭, 黒田一駿, 高麗雅章, 岡﨑敏之, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 塞栓回収療法後の造影剤腎症についての検討, 第21回徳島脳卒中研究会, 2019年2月.
59.	高麗雅章, 里見淳一郎, 山本雄貴, 山本伸昭, 岡﨑敏之, 島田健司, 兼松康久, 髙木康志 : Borden type 1横・S状静脈洞部硬膜動静脈瘻に対するバルーン支援下選択的経静脈塞栓術, 第34回日本脳神経血管内治療学会学術総会, 2018年11月.
60.	高麗雅章, 里見淳一郎, 山本雄貴, 山口泉, 山本伸昭 : Borden type 1 横・S状静脈胴部硬膜動静脈瘻に対するバルーン支援下選択的経静脈塞栓術, 第34回日本脳神経血管内治療学会学術総会, 2018年11月.
61.	高麗雅章, 羽星辰哉, 山本雄貴, 山本伸昭, 岡﨑敏之, 島田健司, 兼松康久, 髙木康志 : 脳腫瘍との鑑別を要した海綿静脈胴部硬膜動静脈瘻の一例, 脳血管内治療ブラッシュアップセミナー2018, 2018年9月.
62.	高麗雅章, 山口泉, 多田恵曜, 兼松康久, 里見淳一郎, 山本伸昭, 山本雄貴, 髙木康志 : 地方国立大学病院における院内発症脳卒中症例の特徴, 第43回日本脳卒中学会学術集会, 2018年3月.
63.	高麗雅章, 里見淳一郎, 山口泉, 兼松康久, 山本伸昭, 山本雄貴, 髙木康志 : 病型別にみた急性期脳主幹動脈閉塞に対する再開通療法, 第47回日本脳卒中の外科学会学術集会, 2018年3月.
64.	庄野健児, 里見淳一郎, 多田恵曜, 兼松康久, 山本伸昭, 和泉唯信, 梶龍兒, 原田雅史, 永廣信治, 髙木康志 : Optimal timing of DWI to avoid false-negative findings in patients with TIA, 第41回日本脳神経CI学会総会, 2018年3月.
65.	青井駿, 梅原英裕, 黒田一駿, 山本伸昭, 大森哲郎 : 幻覚妄想状態の治療後に前頭葉機能低下が残存したパーキンソン病の一例, 第58回中国・四国精神神経学会, 2017年11月.
66.	高麗雅章, 山本雄貴, 山口泉, 山本伸昭, 兼松康久, 髙木康志 : 当院の急性期主幹動脈閉塞に対する再開通療法の治療成績 -病型分類別にみた特徴-, 第33回NPO法人日本脳神経血管内治療学会学術総会, 2017年11月.
67.	高麗雅章, 里見淳一郎, 木内智也, 山本雄貴, 山口泉, 山本伸昭, 兼松康久, 髙木康志 : 病型別にみた急性期脳動脈閉塞に対する再開通療法の治療成績, 日本脳神経外科学会第76回学術総会, 2017年10月.
68.	山本伸昭, 和泉唯信, 梶龍兒, 里見淳一郎, 永廣信治 : 硬膜動静脈瘻ASLの有用性, 日本脳卒中学会学術集会, 2017年3月.
69.	里見淳一郎, 多田恵曜, 山本伸昭, 梶龍兒, 原田雅史, 永廣信治 : 超急性期脳梗塞に必要な画像診断:Stroke MRI用, 第42回日本脳卒中学会学術集会, 2017年3月.
70.	多田恵曜, 山本伸昭, 梶龍兒, 原田雅史, 永廣信治 : 超急性期脳梗塞に必要な画像診断:Stroke MRI, 第42回日本脳卒中学会学術集会, 2017年2月.
71.	兼松康久, 里見淳一郎, 山口泉, 木内智也, 多田恵曜, 山本伸昭, 山本伸昭, 松原俊二, 佐藤浩一, 永廣信治 : 神経症状の改善および安定化を目的として行ったUrgent CASの有効性および安全性の検討, 第32回NPO法人日本脳神経血管内治療学会学術総会, 2016年11月.
72.	山口泉, 里見淳一郎, 山本雄貴, 山本伸昭, 吉岡正太郎, 木内智也, 兼松康久, 永廣信治 : Tandem occlusion症例に対する血管内血行再建術の当院での治療成績, 第32回NPO法人日本脳神経血管内治療学会学術総会, 2016年11月.
73.	木内智也, 山本雄貴, 山口泉, 山本伸昭, 吉岡正太郎, 兼松康久, 里見淳一郎, 原田雅史, 永廣信治 : 発症から6時間を超えた急性期脳梗塞に対する血管内治療の成績, 第32回NPO法人日本脳神経血管内治療学会学術総会, 2016年11月.
74.	山本雄貴, 山本伸昭, 和泉唯信, 梶龍兒, 山口泉, 吉岡正太郎, 木内智也, 兼松康久, 里見淳一郎, 永廣信治 : 超高齢者に対する急性血行再建治療, 第32回NPO法人日本脳神経血管内治療学会学術総会, 2016年11月.
75.	山本伸昭, 山本雄輝, 和泉唯信, 梶龍兒, 山口泉, 木内智也, 兼松康久, 里見淳一郎, 永廣信治 : ASLのCranial Dural Arteriovenous Fistula 診断における有用性, 第32回NPO法人日本脳神経血管内治療学会学術総会, 2016年11月.
76.	多田恵曜, 山本伸昭, 藤原敏孝, 中島公平, 香川幸太, 片桐匡弥, 飯田幸治, 梶龍兒, 永廣信治 : 自己免疫性介在性脳炎後の難治性てんかんの1例, 第50回日本てんかん学会学術集会, 2016年10月.
77.	山口泉, 山本雄貴, 山本伸昭, 吉岡正太郎, 木内智也, 兼松康久, 里見淳一郎, 永廣信治 : Tandem occlusion症例に対する急性期血行再建術の当院での治療成績, 日本脳神経外科学会第75回学術総会, 2016年9月.
78.	木内智也, 兼松康久, 山本雄貴, 山本伸昭, 里見淳一郎, 原田雅史, 永廣信治 : 当院における急性期脳梗塞に対する血管内治療の現状, 日本脳神経外科学会第75回学術総会, 2016年9月.
79.	高橋拓, 垂髪祐樹, 山崎博輝, 古川貴大, 山本伸昭, 松井尚子, 和泉唯信, 梶龍兒 : 発作性心房細動，心筋症を合併した抗ミトコンドリア抗体陽性筋炎の一例, 第100回日本神経学会中国四国地方会, 73, 2016年6月.
80.	古川貴大, 松井尚子, 宮本亮介, 佐光亘, 山本伸昭, 和泉唯信, 高橋幸利, 梶龍兒 : 成人発症の片側大脳萎縮症の臨床像の検討, 第57日本神経学会学術大会, 639, 2016年5月.
81.	牟礼英生, 大北真哉, 山本伸昭 : 変形性脊椎症と特発性正常圧水頭症の合併例の検討, 第17回日本正常圧水頭症学会, 2016年3月.
82.	山口泉, 吉岡正太郎, 山本雄貴, 山本伸昭, 兼松康久, 永廣信治 : ONYXを用いTAEを行った横-S状静脈洞部硬膜動静脈瘻の1例, 第5回脳血管内治療四国遍路塾, 2016年3月.
83.	布村俊幸, 西京子, 兼松康久, 山本伸昭, 里見淳一郎, 永廣信治 : 徳島大学病院脳卒中センターに搬送されたrt-PA静注療法の"Drip and Ship"症例における検討, 第252回徳島医学学術集会, 2016年2月.
84.	松田拓, 住吉学, 山口泉, 吉岡正太郎, 多田恵曜, 八木謙次, 曽我部周, 山本伸昭, 桑山一行, 里見淳一郎, 永廣信治 : MRI CUBE T1が診断の一助となった前大脳動脈解離による脳梗塞の一例, 第80回(一社)日本脳神経外科学会中国四国支部学術集会, 2015年12月.
85.	山口泉, 曽我部周, 吉岡正太郎, 多田恵曜, 桑山一行, 里見淳一郎, 山本伸昭, 永廣信治 : 椎骨脳底動脈閉塞に対するarterial spin labelingの動脈内高信号の有用性, 第31回NPO法人日本脳神経血管内治療学会学術総会,, 2015年11月.
86.	山本伸昭, 和泉唯信, 梶龍兒, 曽我部周, 吉岡正太郎, 桑山一行, 里見淳一郎, 永廣信治 : 主幹動脈閉塞患者における急性血行再建成功例における予後規定因子, 第31回NPO法人日本脳神経血管内治療学会学術総会, 2015年11月.
87.	桑山一行, 山口泉, 曽我部周, 吉岡正太郎, 多田恵曜, 里見淳一郎, 山本伸昭, 永廣信治 : 内頚動脈急性閉塞に対する血管内治療の有効性, 第31回NPO法人日本脳神経血管内治療学会学術総会, 2015年11月.
88.	曽我部周, 里見淳一郎, 多田恵曜, 吉岡正太郎, 山口泉, 山本伸昭, 永廣信治 : Stent retriever導入後の当院での急性期血行再建術, 第31回NPO法人日本脳神経血管内治療学会学術総会, 2015年11月.
89.	吉岡正太郎, 桑山一行, 山本伸昭, 山口泉, 里見淳一郎, 永廣信治 : 急性硬膜外血腫で発症した頭蓋骨内硬膜動静脈瘻に対しNBCAを用いた頸動脈的塞栓術が奏功した1例, 第31回NPO法人日本脳神経血管内治療学会学術総会, 2015年11月.
90.	宮﨑由道, 宮本亮介, 山本伸昭, 和泉唯信, 梶龍兒 : パーキンソン病患者における運動/非運動合併症の誘発危険因子の検討, パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 100, 2015年10月. (キーワード) 危険因子幻覚(病因) 振戦(病因) *Parkinson病(合併症) 妄想(病因) ヒト
91.	山本伸昭, 里見淳一郎, 原田雅史, 多田恵曜, 永廣信治, 梶龍兒 : Is the susceptibility vessel sign on 3-tesla magnetic resonance T2*-weighted imaging a useful tool to predict recanalization?, 第2回日本心血管脳卒中学術総会 2015, 2015年6月.
92.	和泉唯信, 塚本愛, 澤村正典, 山本伸昭, 織田雅也, 小川博久, 瓦井俊孝, 佐田政隆, 宇高不可思, 梶龍兒 : たこつぼ型心筋症を合併した筋萎縮性側索硬化症の2例, 第2回日本心血管脳卒中学会学術集会, 2015年6月.
93.	山本伸昭, 多田恵曜, 里見淳一郎, 和泉唯信, 原田雅史, 永廣信治, 梶龍兒 : The two-layered susceptibility vessel sign on 3-tesla T2*-weighted imaging is a predictive biomarker of stroke subtype, 2015年心血管脳卒中学術総会, 2015年6月.
94.	多田恵曜, 里見淳一郎, 曽我部周, 桑山一行, 永廣信治, 阿部考志, 原田雅史, 原田雅史, 山本伸昭 : Arterial spin labelingの動脈内高信号は急性期中大脳動脈閉塞におけるstagnant flowを反映する, 第2回日本心血管脳卒中学会学術集会, 2015年6月.
95.	曽我部周, 多田恵曜, 里見淳一郎, 桑山一行, 吉岡正太郎, 山口泉, 永廣信治, 山本伸昭, 山田博胤, 若槻哲三, 佐田政隆 : 当院における院内発症脳卒中症例の検討, 第2回日本心血管脳卒中学会学術集会, 2015年6月.
96.	Oki Ryosuke, Kaji Seiji, Osaki Ryosuke, Ryosuke Miyamoto, Nobuaki Yamamoto, Fujita Koji, Toshitaka Kawarai, Yuishin Izumi and Ryuji Kaji : Clinical feature of hereditary diffuse leukoencephalopathy with spheroids (HDLS) in Japan., The 40th Annual Meeting of the Japan Stroke Society., Mar. 2015.
97.	里見淳一郎, 多田恵曜, 桑山一行, 永廣信治, 山本伸昭, 八木謙次, 曽我部周, 吉岡正太郎 : 内頸動脈- 前脈絡叢動脈分岐部動脈瘤に対する治療成績, 第44回日本脳卒中の外科学会, 2015年3月.
98.	山本伸昭, 寺澤由佳, 酒井和香, 和泉唯信, 梶龍兒, 里見淳一郎, 永廣信治, 原田雅史 : Small vessel occlusion患者の神経症状増悪の予測因子, 第40回日本脳卒中学会総会, 2015年3月.
99.	桑山一行, 曽我部周, 多田恵曜, 里見淳一郎, 永廣信治, 山本伸昭 : 病態別にみた急性期頸動脈ステント留置術(CAS)の成績, 第40回日本脳卒中学会総会, 2015年3月.
100.	西京子, 山口真司, 曽我部周, 桑山一行, 里見淳一郎, 永廣信治, 山本伸昭 : 徳島大学病院の初期研修における新たな脳卒中研修の取り組み, 第40回日本脳卒中学会総会, 2015年3月.
101.	曽我部周, 多田恵曜, 桑山一行, 里見淳一郎, 永廣信治, 山本伸昭 : 当院でのstent retrieverの初期使用経験, 第40回日本脳卒中学会総会, 2015年3月.
102.	武藤浩平, 酒井和香, 松井尚子, 沖良祐, 梶誠兒, 武内俊明, 丸山恵子, 大崎裕亮, 山本伸昭, 宮城愛, 野寺裕之, 樋口理, 和泉唯信, 梶龍兒 : 当初ALSを疑われた高齢発症抗MuSK抗体陽性MGの一例, 第97回日本神経学会中国・四国地方会, 2014年12月.
103.	山本伸昭, 和泉唯信, 梶龍兒, 里見淳一郎, 多田恵曜, 永廣信治 : 頸動脈ステント留置後のIn stent plaqueの予測因子, 第30回日本脳神経血管内治療学術総会, 2014年12月.
104.	桑山一行, 曽我部周, 里見淳一郎, 永廣信治, 山本伸昭 : 脳梗塞発症後24時間以内に血管内治療を行った症例の検討, 第30回日本脳神経血管内治療学術総会, 2014年12月.
105.	曽我部周, 多田恵曜, 桑山一行, 里見淳一郎, 永廣信治, 山本伸昭, 和泉唯信 : 小脳萎縮をきたした横静脈洞―S状静脈洞部硬膜動静脈瘻の一例, 第30回日本脳神経血管内治療学術総会, 2014年12月.
106.	山本伸昭, 和泉唯信, 梶龍兒, 曽我部周, 多田恵曜, 桑山一行, 里見淳一郎, 永廣信治 : The high-intense signal on maximum intensity projection images (MIP) of time-of-flight (TOF) magnetic resonance angiography (MRA) can be a predictor of plaque-in-stent after carotid artery stenting, 2014年脳血管内治療学会総会, 2014年12月.
107.	竹内俊明, 宮本亮介, 大崎裕亮, 山本伸昭, 藤田浩司, 松井尚子, 和泉唯信, 梶龍兒 : 弛緩性麻痺と不随意運動を呈した日本脳炎の一例, 第111回日本内科学会四国地方会, 2014年11月.
108.	山口真司, 多田恵曜, 里見淳一郎, 桑山一行, 曽我部周, 永廣信治, 山本伸昭 : 3テスラT2*強調画像のischemic vessel sign はCEA，CAS術後過灌流の予測に有用か, 第26回日本脳循環代謝学会, 2014年11月.
109.	多田恵曜, 里見淳一郎, 桑山一行, 曽我部周, 永廣信治, 山本伸昭 : CEA，CAS術後過灌流の予測における3テスラT2*強調画像の虚血所見の検討, 第73回日本脳神経外科学会学術総会, 2014年10月.
110.	永廣信治, 里見淳一郎, 桑山一行, 曽我部周, 山本伸昭, 和泉唯信, 梶龍兒 : Floating thrombus を認め，進行性の経過を呈した頸動脈高度狭窄の1例, 第16回中国四国脳卒中研究会, 2014年9月.
111.	多田恵曜, 里見淳一郎, 曽我部周, 桑山一行, 永廣信治, 阿部考志, 原田雅史, 山本伸昭 : 中大脳動脈閉塞例におけるarterial spin labelingの動脈内高信号の検討, 第1回日本心血管脳卒中学会学術集会, 2014年6月.
112.	山本伸昭, 寺澤由佳, 藤田浩司, 和泉唯信, 梶龍兒, 森垣龍馬, 多田恵曜, 里見淳一郎, 永廣信治 : 急性期虚血性脳卒中患者のT2*強調画像所見とその変化, 2014年脳卒中学会総会, 2014年3月.
113.	山本伸昭, 里見淳一郎, 寺澤由佳, 曽我部周, 中島公平, 佐藤泰仁, 坂東一彦, 阿川昌仁, 浅野登, 本藤秀樹, 和泉唯信, 梶龍兒, 永廣信治 : 脳梗塞発症後早期からの抗血小板薬使用が予後に及ぼす影響の検討, 2014年脳卒中学会総会, 2014年3月.
114.	宮﨑由道, 宮城愛, 山本伸昭, 佐藤健太, 寺澤由佳, 松井尚子, 浅沼光太郎, 和泉唯信, 梶龍兒 : t-PA治療が奏功した超高齢発症脳梗塞の2例, 日本老年医学会雑誌, Vol.48, No.4, 418, 2011年. (キーワード) 脳梗塞(薬物療法) Tissue Plasminogen Activator(治療的利用) ヒト高齢者(80~) 女
115.	宮﨑由道, 山本伸昭, 藤田浩司, 中村和己, 和泉唯信, 梶龍兒 : 脳小血管病変(SVD)はパーキンソン症状を悪化させる, 臨床神経学, Vol.50, No.12, 1248, 2010年. (キーワード) 血管疾患病勢悪化パーキンソニズム(合併症) 脳小血管病(合併症) ヒト

その他・研究会:

1.	高麗雅章, 里見淳一郎, 山本雄貴, 山本伸昭, 兼松康久, 髙木康志 : 二期的に治療した海綿静脈胴部硬膜動静脈瘻の1例, 第7回脳血管内治療四国遍路塾, 2018年3月.
2.	高麗雅章, 里見淳一郎, 山本雄貴, 山口泉, 山本伸昭, 兼松康久, 髙木康志 : 頸動脈ステント留置術後10日目に過灌流による脳出血を来した1例, 第5回徳島脳疾患談話会, 2018年3月.
3.	鹿草宏, 兼松康久, 山本雄貴, 高麗雅章, 山本伸昭, 里見淳一郎, 髙木康志 : 急性期血行再建術後に腎不全をきたした1例, 第43回徳島脳神経外科談話会, 2017年12月.
4.	山本雄貴, 山本伸昭, 和泉唯信, 山口泉, 高麗雅章, 木内智也, 兼松康久, 里見淳一郎, 永廣信治 : 頭蓋頚椎移行部 Perimedullary AVF の血管内治療例, 第19回徳島脳血管障害カンファレンス, 2017年5月.
5.	高麗雅章, 木内智也, 兼松康久, 山本雄貴, 山本伸昭, 里見淳一郎 : Blebの塞栓中に破裂した前交通動脈瘤の1例, 第53回近畿脳神経血管内治療法ワークショップ, 2017年1月.
6.	山口泉, 里見淳一郎, 曽我部周, 吉岡正太郎, 中島公平, 木内智也, 兼松康久, 山本雄輝, 山本伸昭, 若槻哲三, 永廣信治 : OCTを用いて塞栓源を同定しえた一例, 第8回徳島Vascular Imaging研究会, 2016年7月.
7.	曽我部周, 里見淳一郎, 中島公平, 山口泉, 桑山一行, 吉岡正太郎, 永廣信治, 山本伸昭, 若槻哲三 : 光干渉断層法を用いて塞栓源を同定しえた脳梗塞の一例, 第24回NPO法人日本脳神経血管内治療学会中国四国地方会, 2015年9月.
8.	山本伸昭, 梶龍兒, 里見淳一郎, 曽我部周, 桑山一行, 永廣信治 : The 2-layered SVS can predict stroke subtypes, 第34回The Mt. Fuji Workshop on CVD, 2015年8月.
9.	山本伸昭, 梶龍兒, 里見淳一郎, 曽我部周, 桑山一行, 永廣信治 : The 2-layered SVS can predict stroke subtypes, 第34回The Mt. Fuji Workshop on CVD, 2015年8月.
10.	曽我部周, 里見淳一郎, 中島公平, 山口泉, 桑山一行, 吉岡正太郎, 永廣信治, 山本伸昭, 若槻哲三 : OCTを用いて塞栓源を同定しえた脳梗塞の1例, 第17回徳島脳血管障害カンファレンス, 2015年5月.
11.	山本伸昭, 和泉唯信, 梶龍兒, 曽我部周, 吉岡正太郎, 多田恵曜, 桑山一行, 里見淳一郎, 永廣信治 : 急性期再灌流療法施行患者の予後予測因子, 第17回徳島脳血管障害カンファレンス, 2015年5月.
12.	羽星辰哉, 曽我部周, 山口泉, 吉岡正太郎, 山本伸昭, 桑山一行, 里見淳一郎, 永廣信治 : 当院脳卒中センターにおけるDrip,Ship & Retrieve症例の検討, 第17回徳島脳卒中研究会, 2015年2月.
13.	山本伸昭, 藤田浩司, 和泉唯信, 梶龍兒, 山口泉, 里見淳一郎, 永廣信治, 山田博胤, 木下肇, 北川哲也 : 心内巨大血栓に伴う急性期脳梗塞の1例, 第16回徳島脳血管障害カンファレンス, 2014年4月.
14.	里見淳一郎, 桑山一行, 曽我部周, 永廣信治, 山本伸昭 : くも膜下出血で発症した両側IC-PC分岐部動脈瘤の1例, 第3回脳血管内治療四国遍路塾, 2014年3月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

研究者番号（40815578）による検索

特任講師 : 山本伸昭

研究活動

専門分野

研究テーマ

著書・論文

著書:

学術論文(審査論文):

学術論文(紀要・その他):

総説・解説:

国際会議:

国内講演発表:

その他・研究会:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

特任講師 : 山本 伸昭

研究活動

専門分野

研究テーマ

著書・論文

著書:

学術論文(審査論文):

学術論文(紀要・その他):

総説・解説:

国際会議:

国内講演発表:

その他・研究会:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

特任講師 : 山本伸昭