Tokushima University / Educator and Researcher Directory --- Irahara, Makoto

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Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 医学域 ⟩ 先端医学教育研究プロジェクト ⟩
Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 医学域 ⟩ Medical Science ⟩ Internal Medicine ⟩ Department of Pediatrics ⟩

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Research

Personal Web Page

https://researchmap.jp/irahara_makoto (researchmap)

https://orcid.org/0000-0001-7007-445X (ORCID)

Field of Study

○	Life sciences [Allergies and connective tissue disease]
○	Life sciences [Fetal medicine/Pediatrics]

Subject of Study

Book / Paper

(See https://researchmap.jp/irahara_makoto (researchmap) for Published Book / Papers / Presentations.)

Academic Paper (Judged Full Paper):

1.	Makoto Irahara, Wakako Shinahara, Mayumi Sugimoto, Yukiko Ogawa, Keiji Shitsukawa, Kenji Kubota, Limin Yang, Yukihiro Ohya, Hirohisa Saito, Shoji Kagami, Kokichi Arisawa and Hiroshi Kido : Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy, Immunity, Inflammation and Disease, 7, 2, 74-85, 2019. (Summary) Allergen-specific immunoglobulin isotype formation associated with immunoglobulin class-switching during the lactation period is the immunological background for food allergy in infants. We analyzed the serial changes in the production of feeding type-related egg- and milk-specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants. Allergen-specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen's egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray. Formula and mixed feeding were associated with a rapid increase in cow's milk allergen-specific immunoglobulins and feeding type-related significant differences in casein-specific immunoglobulin levels were detected. Breast and mixed feeding were associated with slow but significant increase in ovalbumin-specific IgG1 and IgE levels, but not other immunoglobulins. We found two different immunoglobulin isotype formation at 6 months of age with low- or high-affinity IgE against ovalbumin. One isotype formation pattern had relatively high ovalbumin-specific IgG1 levels, detectable IgG2, and low-affinity IgE, while the other had low ovalbumin-specific IgG1 levels, undetectable IgG2, and high levels of high-affinity IgE. The incidence of eczema was significantly higher in the latter pattern (84.6%), compared with the remaining infants (42.2%). Feeding practice-related allergen sensitization and immunoglobulin isotype formation were identified during the lactation period. The development of eczema during the lactation period could potentially modify the immunoglobulin isotype formation with high levels of high-affinity IgE. (Keyword) Age Factors / Allergens / Animals / Antibody Affinity / Antibody Formation / Antibody Specificity / Cattle / Chickens / Eczema / Egg Hypersensitivity / Eggs / female / Humans / Immunoglobulin Class Switching / Immunoglobulin E / Immunoglobulin Isotypes / infant / Infant, Newborn / male / Milk / Milk Hypersensitivity / Pregnancy (Tokushima University Institutional Repository) ● Metadata: 2007245 (Link to Publication Site) ● Publication site (DOI): 10.1002/iid3.245 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30859748 ● Summary page in Scopus @ Elsevier: 2-s2.0-85062790988 (Tokushima University Institutional Repository: 2007245, DOI: 10.1002/iid3.245, PubMed: 30859748, Elsevier: Scopus)
2.	Mayumi Sugimoto, Norio Kamemura, Mizuho Nagao, Makoto Irahara, Shoji Kagami, Takao Fujisawa and Hiroshi Kido : Differential response in allergen-specific IgE, IgGs and IgA levels for predicting outcome of oral immunotherapy., Pediatric Allergy and Immunology, 27, 3, 276-282, 2016. (Summary) The response to OIT was associated with significant increases in serum allergen-specific IgG1 levels after rush phase and high baseline IgA levels, compared with small changes in immunoglobulin response in low-responders. The characteristic IgG1 changes and IgA levels in the responders could be potentially useful biomarkers for the prediction of positive clinical response to OIT. This article is protected by copyright. All rights reserved. (Tokushima University Institutional Repository) ● Metadata: 2002927 (Link to Publication Site) ● Publication site (DOI): 10.1111/pai.12535 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26764899 ● Summary page in Scopus @ Elsevier: 2-s2.0-84959202502 (Tokushima University Institutional Repository: 2002927, DOI: 10.1111/pai.12535, PubMed: 26764899, Elsevier: Scopus)

Proceeding of Domestic Conference:

1.	Hiroshi Kido, Makoto Irahara, 品原和加子, Mayumi Sugimoto and Shoji Kagami : 生後6ヵ月までの母乳栄養児と人工乳栄養児の抗原摂取量の違いを背景とした湿疹誘発IgEクラススイッチパターンの違い, 第54回日本小児アレルギー学会学術大会, Nov. 2017.
2.	佐々木亜由美, Mayumi Sugimoto, 戸梶成美, Makoto Irahara, 寺田知正 and Shoji Kagami : 6種除去療法が有用であった好酸球性胃腸炎の1例, 第54回日本小児アレルギー学会学術大会, Nov. 2017.
3.	Makoto Irahara, 佐々木陽平, 品原和加子, Mayumi Sugimoto, Shoji Kagami and Hiroshi Kido : 乳児期におけるイムノグロブリンクラススイッチの進展と抗原親和性, 第66回日本アレルギー学会学術大会, Jun. 2017.
4.	Mayumi Sugimoto, Makoto Irahara and Shoji Kagami : 鶏卵少量負荷試験とその後の摂取状況に関する検討, 第66回日本アレルギー学会学術大会, Jun. 2017.
5.	戸梶成美, Makoto Irahara, Mayumi Sugimoto, 佐々木亜由美, 寺田知正 and Shoji Kagami : 大豆が原因と考えられた好酸球性胃腸炎の一例, 第147回日本小児科学会徳島地方会, Dec. 2016.
6.	Makoto Irahara, Mayumi Sugimoto and Shoji Kagami : 多抗原の食物除去が身体発育に与える影響, 第53回日本小児アレルギー学会, Oct. 2016.
7.	Makoto Irahara, Mayumi Sugimoto and Shoji Kagami : 多抗原の食物除去が身体発育に与える影響, 第146回日本小児科学会徳島地方会, Jun. 2016.
8.	Makoto Irahara, 佐々木陽平, 品原和加子, Mayumi Sugimoto, Shoji Kagami and Hiroshi Kido : 0-6ヵ月乳児のアレルゲン特異的抗体価イムノグロブリンクラススイッチの検討, 第65回日本アレルギー学会学術大会, Jun. 2016.
9.	Makoto Irahara, 佐々木陽平, 品原和加子, Mayumi Sugimoto, Shoji Kagami and Hiroshi Kido : 乳児期の卵白アレルゲン特異的IgE抗体の低から高親和性変化の検討, 第65回日本アレルギー学会学術大会, Jun. 2016.
10.	Makoto Irahara, Matsumoto Sonomi, Mayumi Sugimoto, Mori Kazuhiro and Shoji Kagami : 著明な体重減少，低蛋白血症，電解質異常を呈したアトピー性皮膚炎の乳児例, 第119回日本小児科学会学術集会, May 2016.
11.	Mayumi Sugimoto, Makoto Irahara and Shoji Kagami : 当院における鶏卵負荷試験症例に関する検討, 第145回日本小児科学会徳島地方会, Dec. 2015.
12.	Makoto Irahara, 本間友佳子, 松崎苑美, Mayumi Sugimoto and Shoji Kagami : 呼気性喘鳴を伴う急性呼吸不全に対してHigh flow nasal cannulaを使用した3例, 第52回日本小児アレルギー学会, Nov. 2015.
13.	Mayumi Sugimoto, 本間友佳子, 松崎苑美, Makoto Irahara and Shoji Kagami : 呼気性喘鳴を伴う急性呼吸不全に対するHigh flow nasal cannulaの使用経験, 第27回四国小児アレルギー研究会, Jun. 2015.
14.	Makoto Irahara, Mayumi Sugimoto, Shoji Kagami, 松本苑美 and Kazuhiro Mori : 著明な体重増加不良，低蛋白血症，電解質異常を呈したアトピー性皮膚炎の乳児例, 第144回日本小児科学会徳島地方会, Jun. 2015.
15.	Mayumi Sugimoto, shinniti yamada, 市岡隆男, 榎本新也, 田口義行, 田中宏実, 久原孝, 七條光市, Makoto Irahara, 田山正伸 and Shoji Kagami : 徳島県における食物アレルギー対応の現状と今後の取り組みについて, 第143回日本小児科学会徳島地方会, Dec. 2014.
16.	林大輔, 立元千帆, 今村直人, 北條菜穂, 今井孝成, 野村伊知郎, 堀向健太, 大矢幸弘, Makoto Irahara, Mayumi Sugimoto, 新垣洋平 and 松本健治 : 乳による誘発の既往が無いSolid FPIESの感作経路に関する検討, 第51回日本小児アレルギー学会, Nov. 2014.

Et cetera, Workshop:

1.	戸梶成美, Makoto Irahara, Mayumi Sugimoto, 佐々木亜由美, 寺田知正 and Shoji Kagami : 大豆が原因と考えられた好酸球性胃腸炎の一例, 第29回四国小児アレルギー研究会, Jun. 2017.
2.	Mayumi Sugimoto, Makoto Irahara, 森一博, 七條光市 and Shoji Kagami : 徳島県における小児の喘息発作入院の状況, 第28回四国小児アレルギー研究会, Jun. 2016.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Prevention of allergic disease based on allergen-specific IgG4 levels in cord blood (Project/Area Number: 20K17457 )
Search by Researcher Number (50767910)