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Tokushima University > Research Clusters > Research Clusters (Registered) > 1704050 歯髄由来細胞の細胞記憶の賦活とバイオマテリアルへの融合による新規再生医療材の創生 >
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Research Activity

Field of Study

Bone and Mineral Metabolism
Biomaterials
Prosthodontics

Subject of Study

Effect of anti- Dickkopf1 (DKK-1) antibodies on osteogenic differentiation of bone marrow cells and osteoporosis (anti DKK-1 antibody, osteogenic differentiation, osteoporosis)
Effect of bone formation using TNF-α treated carbonate apatite and hydroxyapatite (carbonate apatite, tumor necrosis factor-α, bone formation)
Evaluation of masticator and satisfaction of making new full denture patient (full denture, masticator, satisfaction)

Book / Paper

Academic Paper (Judged Full Paper):

1. Resmi Raju, Masamitsu Ohshima, Miho Inoue, Tsuyoshi Morita, Yan Huijiao, Arief Waskitho, Otto Baba, Masahisa Inoue and Yoshizo Matsuka :
Three-dimensional periodontal tissue regeneration using a bone-ligament complex cell sheet,
Scientific Reports, Vol.10, No.Article number: 1656, 2020.
(Tokushima University Institutional Repository: 114213,   DOI: 10.1038/s41598-020-58222-0)
2. Takuma Iwasa, S Afroz, Miho Inoue, Rieko Arakaki, Masamitsu Ohshima, R Raju, Arief Waskitho, Inoue Masahisa, Otto Baba and Yoshizo Matsuka :
IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain,
Neuroscience Letters, Vol.703, 132-138, 2019.
(Tokushima University Institutional Repository: 113686,   DOI: 10.1016/j.neulet.2019.03.031)
3. Mio Naritani, Miho Inoue, Resmi Raju, Mayu Miyagi, Masamitsu Ohshima and Yoshizo Matsuka :
Analysis of Bone Marrow-derived Mesenchymal Stem Cell Kinetics after Short-term Stimulation with Tumor Necrosis Factor-α (TNF-α),
Journal of Hard Tissue Biology, Vol.28, No.2, 99-108, 2019.
(Tokushima University Institutional Repository: 113372,   DOI: 10.2485/jhtb.28.99,   Elsevier: Scopus)
4. S Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Otto Baba, Yoshihiro Okayama and Yoshizo Matsuka :
CGRP induces differential regulation of cytokines from satellite glial cells in trigeminal ganglia and orofacial nociception,
International Journal of Molecular Sciences, Vol.20, No.3, 711-730, 2019.
(Tokushima University Institutional Repository: 113687,   DOI: 10.3390/ijms20030711,   PubMed: 30736422,   Elsevier: Scopus)
5. Miho Inoue, Mio Naritani, R Raju, Mayu Miyagi, Masamitsu Ohshima, Inoue Masahisa and Yoshizo Matsuka :
Effect of short-term Tumour Necrosis Factor-alpha (TNF-α) -stimulation on the growth and differentiation of MC3T3-E1 osteoblast-like cells,
Journal of Hard Tissue Biology, Vol.27, No.3, 213-218, 2018.
(DOI: 10.2485/jhtb.27.213,   Elsevier: Scopus)
6. Keisuke Nishigawa, Rika Hayama, Ktsushi Omoto, Kazuo Okura, Toyoko Tajima, Yoshitaka Suzuki, Maki Hosoki, Mayu Miyagi, Miho Inoue, Omar Maningo Rodis and Yoshizo Matsuka :
Validity of peer evaluation for team-based learning in a dental school in Japan,
Journal of Dental Education, Vol.81, No.12, 1451-1456, 2017.
(Tokushima University Institutional Repository: 112932,   DOI: 10.21815/JDE.017.106,   PubMed: 29196333,   Elsevier: Scopus)
7. Miho Inoue, Hiroh Kawahara, Kazuo Okura, Omar Maningo Rodis and Yoshizo Matsuka :
Frequency of congenitally missing permanent teeth at a primary dental care clinic in Tokushima, Japan,
The Journal of Japan Association of Oral Rehabilitation, Vol.30, No.1, 67-70, 2017.
(CiNii: 40021481734)

Proceeding of International Conference:

1. R Raju, Masamitsu Ohshima, Tsuyoshi Morita, Huijiao Yan, Miho Inoue, Otto Baba, Masahisa Inoue and Yoshizo Matsuka :
A composite cell sheet fabrication and its usage in periodontal tissue regeneration,
Asian international Association of Dental Traumatology, Cebu, Mar. 2020.
2. R Raju, Masamitsu Ohshima, Tsuyoshi Morita, Huijiao Yan, Miho Inoue, Otto Baba, Masahisa Inoue and Yoshizo Matsuka :
A double-layered complex cell sheet can regenerate the periodontal tissue in a mice model,
Dentisphere, Surabayai, Nov. 2019.
3. S Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Otto Baba, Okayama Yoshihiro and Yoshizo Matsuka :
Orofacial nociception due to glial expressed cytokines in trigeminal ganglia,
International Association for Dental Research, Vancouver, Jun. 2019.
4. Iwasa Takuma, Rieko Arakaki, Oshima Masamitsu, S Afroz, Miho Inoue, Goto Nami, Naozumi Ishimaru and Yoshizo Matsuka :
Up-regulation of inflammatory cytokines in trigeminal ganglia after infraorbital nerve constriction,
The Journal of Neuroscience, Washington DC, Nov. 2017.

Proceeding of Domestic Conference:

1. Masamitsu Ohshima, Raju Resmi, Miho Inoue, Mayu Miyagi and Yoshizo Matsuka :
骨‐歯根膜線維の複合組織形成による三次元組織再生技術の開発,
The Journal of the Japan Prosthodontic Society, Jun. 2020.
2. Takuma Iwasa, Miho Inoue, Raju Resmi, Masamitsu Ohshima and Yoshizo Matsuka :
IL-10は神経障害性疼痛を抑制する,
The Journal of the Japan Prosthodontic Society, Jun. 2020.
3. 葉山 莉香, Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Omar Marianito, Takuma Iwasa and Yoshizo Matsuka :
補綴学授業におけるアクティブラーニングによる学修効果-反転授業とTBLの長期比較-,
徳島県歯科医学大会, Feb. 2020.
4. Takuma Iwasa, Afroz Shaista, Miho Inoue, Rieko Arakaki, Masamitsu Ohshima, Raju Resmi, Arief Waskitho, 井上 正久, Otto Baba and Yoshizo Matsuka :
痛みに対するサイトカイン療法の開発に向けて,
徳島県歯科医学大会, Feb. 2020.
5. Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Takuma Iwasa and Yoshizo Matsuka :
歯科補綴学授業におけるアクティブラーニングの学修効果―反転授業とTBL,通常授業の比較―,
大学教育カンファレンスin徳島, Dec. 2019.
6. Raju Resmi, Masamitsu Ohshima, Miho Inoue, Tsuyoshi Morita, Yan Huijiao, Otto Baba, Inoue Masahisa and Yoshizo Matsuka :
Development of a multilayered complex cell sheet to regenerate periodontal tissue,
Tokushima University Bioscience Retreat, Sep. 2019.
7. Yuehui Zhang, Maki Hosoki, Masamitsu Ohshima, Mayu Miyagi, 成谷 美緒, Miho Inoue and Yoshizo Matsuka :
金属アレルギー患者群と健常者群における特異的マイクロRNAの同定,
日本補綴歯科学会 中国・四国支部学術大会, Sep. 2019.
8. 成谷 美緒, Maki Hosoki, Mayu Miyagi, Masamitsu Ohshima, Miho Inoue, 岩浅 匠真 and Yoshizo Matsuka :
金属アレルギー患者に対する血管内治療の術前評価,
日本補綴歯科学会 中国・四国支部学術大会, Sep. 2019.
9. Maki Hosoki, Yuehui Zhang, Masamitsu Ohshima, Miho Inoue, 成谷 美緒, Mayu Miyagi and Yoshizo Matsuka :
血中マイクロRNAを介した金属アレルギーの感作・発症機序の解明,
歯科医学を中心とした総合的な研究を推進する集い, Aug. 2019.
10. Raju Resmi, Masamitsu Ohshima, Miho Inoue, Tsuyoshi Morita, Yan Huijiao, Otto Baba, 井上 正久 and Yoshizo Matsuka :
骨芽細胞と歯根膜細胞との立体形成複合細胞シートによる歯周組織再生の確立,
硬組織再生生物学会, Aug. 2019.
11. Kazuo Okura, Miho Inoue, Maki Hosoki, Fumiaki Kawano and Yoshizo Matsuka :
卒前専門基礎教育におけるアクティブラーニングの導入とその学習効果―反転授業とTBLの比較―,
The Journal of Japanese Dental Education Association, Jul. 2019.
12. Miho Inoue, Raju Resmi, Takuma Iwasa, 秋山 謙太郎, Masamitsu Ohshima, 窪木 拓男 and Yoshizo Matsuka :
抗Dickkopf1 (DKK-1) 抗体による骨分化能メカニズムの解明,
The Journal of the Japan Prosthodontic Society, May 2019.
13. Maki Hosoki, Miho Inoue, Takuma Iwasa, Yasufumi Nishikawa, 秋月 皆人, 吉原 靖智, Kazuo Okura, Yuehui Zhang, Huijiao Yan, Arief Waskitho, Rodrigo Shigeru Ofuchi, Masamitsu Ohshima, Yoshitaka Suzuki, 成谷 美緒, Mayu Miyagi, Raju Resmi and Yoshizo Matsuka :
歯科補綴学(Ⅱ)実習における実習書改定後の検討in徳島,
大学教育カンファレンス, Dec. 2018.
14. Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, 岩浅 匠真, Junhel Dalanon and Yoshizo Matsuka :
歯科補綴学授業におけるアクティブラーニングの学修効果-反転授業とTBLの比較-,
大学教育カンファレンスin徳島, Dec. 2018.
15. Maki Hosoki, Mayu Miyagi, Miho Inoue, Kazuo Okura, Masamitsu Ohshima, Raju Resmi, 岩浅 匠真, 成谷 美緒, Zhang Yuehui, Yan Huijiao, Arief Waskitho, Junhel Dalanon, Yoshitaka Suzuki, 吉原 靖智 and Yoshizo Matsuka :
歯科補綴学実習における実習書の改訂とその効果の検討,
大学教育カンファレンスin徳島, Dec. 2018.
16. 川原 博雄, Miho Inoue, Masamitsu Ohshima, Kazuo Okura, Maki Hosoki, Toyoko Tajima and Yoshizo Matsuka :
一般歯科診療所での長期メインテナンス患者における歯の喪失原因の評価,
日本補綴歯科学会中国・四国支部学術大会, Sep. 2018.
17. Raju Resmi, Miho Inoue, 宮城 麻友, 秋山 謙太郎, Masamitsu Ohshima, 井上 正久 and Yoshizo Matsuka :
抗Dickkopf1 (DKK-1) 抗体による骨髄細胞の骨分化能への影響,
硬組織再生生物学会, Aug. 2018.
18. Miho Inoue, Raju Resmi, Masamitsu Ohshima, 梶本 昇, 都留 寛治, 石川 邦夫, 井上 正久 and Yoshizo Matsuka :
Tumor necrosis factor (TNF)-α処理炭酸アパタイトおよびハイドロキシアパタイトが骨形成におよぼす影響,
硬組織再生生物学会, Aug. 2018.
19. 岩浅 匠真, Afroz Shaista, Casinilo Junhel Dalanon, Masamitsu Ohshima, Kazuo Okura, Miho Inoue and Yoshizo Matsuka :
三叉神経痛モデルラットにおける炎症性サイトカインの変動解析,
日本顎関節学会・日本口腔顔面痛学会・日本歯科心身医学会, Jul. 2018.
20. Kouhei Kamoi, Yoshitaka Suzuki, Kazuo Okura, 宮城 麻友, Miho Inoue, Masamitsu Ohshima, Yuji Shimizu and Yoshizo Matsuka :
ナイトガードの咬耗面を3次元画像解析装置にて定量評価した症例,
Shikoku Dental Research, Mar. 2018.
21. Kazuo Okura, Keisuke Nishigawa, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, 宮城 麻友, Miho Inoue, Takuma Iwasa, Rika Hayama and Yoshizo Matsuka :
歯科補綴学授業におけるアクティブラーニングの効果 ―反転授業とTBLの比較―,
教育カンファレンスin徳島, Dec. 2017.
22. S Afroz, Iwasa Takuma, Masamitsu Ohshima, Rieko Arakaki, Miho Inoue, Naozumi Ishimaru and Yoshizo Matsuka :
Cytokine released by satellite glial cells and pain transmission in sensory ganglions,
Japan Association for Dental Research, Nov. 2017.
23. Hiroh Kawahara, Miho Inoue, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka :
長期的メインテナンス患者における歯の喪失に関する後ろ向き調査,
The Journal of Japan Association of Oral Rehabilitation, Nov. 2017.
24. Takuma Iwasa, S. Afroz, Mio Naritani, 宮城 麻友, Miho Inoue, Masamitsu Ohshima and Yoshizo Matsuka :
神経障害性痛モデルラットに対するボツリヌス毒素の効果,
日本ボツリヌス治療学会, Sep. 2017.
25. Raju Resmi, Miho Inoue, Mio Naritani, 宮城 麻友, 織田 英正, 友永 泰弘, Masamitsu Ohshima and Yoshizo Matsuka :
骨髄由来間葉系細胞におけるTNF-α短期刺激による細胞動態の解析,
日本補綴歯科学会 中国四国支部学術大会, Aug. 2017.
26. Miho Inoue, Mio Naritani, R. Raju, 宮城 麻友, Y. Zhang, Masamitsu Ohshima, 井上 正久 and Yoshizo Matsuka :
骨髄細胞,骨芽細胞様細胞におけるTNF-α短期間刺激による細胞挙動の解析,
日本硬組織再生生物学会, Aug. 2017.
27. Takuma Iwasa, Masamitsu Ohshima, Kazuo Okura, Miho Inoue, S. Afroz and Yoshizo Matsuka :
口腔顎顔面痛モデル三叉神経節におけるサイトカイン動態,
Japanese Journal of Orofacial Pain, Jul. 2017.
28. Daiki Teruya, Miho Inoue, Mio Naritani, R. Raju, 宮城 麻友, Masamitsu Ohshima and Yoshizo Matsuka :
骨髄細胞,骨芽細胞様細胞におけるTNF-α短期刺激による細胞学的・組織学的検討,
The Journal of the Japan Prosthodontic Society, Jul. 2017.
29. Daiki Teruya, Miho Inoue, Mio Naritani, R. Raju, 宮城 麻友, Masamitsu Ohshima and Yoshizo Matsuka :
TNF-α短期刺激による骨髄細胞の細胞学的検討,
Shikoku Dental Research, Jun. 2017.
30. Miho Inoue, Mio Naritani, R. Raju, Mayu Miyagi and Yoshizo Matsuka :
腫瘍壊死因子TNF-αによる歯髄細胞,骨髄細胞の幹細胞化,
徳島大学大学院医歯薬学研究部 発生・再生・遺伝クラスター・ミニリトリート, Mar. 2017.
31. Yoshizo Matsuka, Takuma Iwasa, S. Afroz, Katsuhiro Ohmoto, Miho Inoue, Mio Naritani, Mayu Miyagi and Kazuo Okura :
末梢知覚神経節における神経伝達物質による痛み情報伝達,
徳島大学医歯薬学研究部脳科学クラスター・ミニリトリート, Mar. 2017.
32. Kazuo Okura, Keisuke Nishigawa, Maki Hosoki, Toyoko Tajima, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, 大本 勝弘, 葉山 莉香 and Yoshizo Matsuka :
歯科補綴学授業におけるアクティブラーニングの効果 ―反転授業とTBLの比較―,
大学教育再生加速プログラムシンポジウム, Dec. 2016.
33. 藤枝 創, Maki Hosoki, Keisuke Nishigawa, Miho Inoue, 中川 敬司, Kouhei Kamoi, takayoshi oshio, 宮本 裕司 and Yoshizo Matsuka :
ジルコニア切削方法の違いが強度におよぼす影響について,
日本補綴歯科学会 九州,中国・四国支部学術大会, Sep. 2016.
34. Mayu Miyagi, Miho Inoue, 福本 美緒 and Yoshizo Matsuka :
炎症環境による歯髄細胞の幹細胞化―歯髄細胞分化に与える TNF-αの影響―,
The Journal of Japanese Society of Stomatognathic Function, Apr. 2016.
35. Yoshizo Matsuka, 大本 勝弘, 岩浅 匠真, Miho Inoue, 福本 美緒, Mayu Miyagi and Kazuo Okura :
知覚神経節における神経伝達物質による痛み情報伝達の可能性,
The Journal of Japanese Society of Stomatognathic Function, Apr. 2016.

Et cetera, Workshop:

1. Raju Resmi, Masamitsu Ohshima, Tsuyoshi Morita, Yan Huijiao, Miho Inoue, Otto Baba, Inoue Masahisa and Yoshizo Matsuka :
Three-dimensional periodontal tissue regeneration using a bone-ligament complex cell sheet,
発生・再生・遺伝クラスター ミニリトリート, Feb. 2020.
2. Resmi Raju, Miho Inoue, M. Naritani, Mayu Miyagi, Yuehui Zhang, Masamitsu Oshima, Masahisa Inoue and Yoshizo Matsuka :
Cellular kinetics of bone marrow derived mesenchymal cells by short-term TNF-alpha stimulation,
Tokushima University Bioscience Retreat, Sep. 2017.
3. S. Afroz, Iwasa Takuma, Oshima Masamitsu, Rieko Arakaki, Miho Inoue, Naozumi Ishimaru and Yoshizo Matsuka :
Cytokine release from satellite glial cells of trigeminal ganglia,
Tokushima University Bioscience Retreat, Sep. 2017.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Development of a bio-artificial tooth root based on the mechanism for periodontal tissue formation and maturation by using occlusal stress. (Project/Area Number: 19K10208 )
  • 骨形成作用を有する抗DKK-1抗体の効果メカニズムの解明 (Project/Area Number: 17K11753 )
  • 歯髄細胞の幹細胞化を応用した新規治療法の開発 (Project/Area Number: 16K11600 )
  • 金属アレルギー;感作と発症間に何があるのか?―特異的遺伝子の同定― (Project/Area Number: 16K11599 )
  • The development of new baiomaterial promoted regeneration of a dental pulp and odontoblast. (Project/Area Number: 15H06450 )
  • Molecular biological analysis of oral bacterial population dynamics (Project/Area Number: 10671699 )
  • Development of inhibitors for a angiogenesis factor CTGF and its application for angiogenetic diseases (Project/Area Number: 10557165 )
  • Molecular cloning of the receptors for chondrosarcoma-derived chondrocyte growth factor Ecogenin/CTGF (Project/Area Number: 09671893 )
  • Ecological analysis of Helicobacter pylori in oral cavities (Project/Area Number: 08672069 )
  • 若年性歯周病原性細菌が産生する白血球毒素蛋白質の機能領域の同定 (Project/Area Number: 07771611 )
  • Function and structure of glucosyltransferase of Streptococcus sobrinus (Project/Area Number: 06671811 )
  • Search by Researcher Number (20271059)