Tokushima University / Educator and Researcher Directory --- Inoue, Miho

Field of Study

○	Bone and Mineral Metabolism
○	Biomaterials
○	Prosthodontics

Subject of Study

○	Effect of anti- Dickkopf1 (DKK-1) antibodies on osteogenic differentiation of bone marrow cells and osteoporosis (anti DKK-1 antibody, osteogenic differentiation, osteoporosis)
○	Effect of bone formation using TNF-α treated carbonate apatite and hydroxyapatite (carbonate apatite, tumor necrosis factor-α, bone formation)
○	Evaluation of masticator and satisfaction of making new full denture patient (full denture, masticator, satisfaction)

Book / Paper

Academic Paper (Judged Full Paper):

1.	Yoshitaka Suzuki, Kazuo Okura, Toyoko Tajima, Junhel Dalanon, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Mayu Miyagi, Daisuke Ikutame and Yoshizo Matsuka : Essence of diagnosis and management of sleep bruxism, Journal of Oral Health and Biosciences, Vol.36, No.2, 22-29, 2024.
2.	Huijiao Yan, Masamitsu Ohshima, Raju Raju, S Raman, Kazumitsu Sekine, Arief Waskitho, Miho Inoue, Masahisa Inoue, Otto Baba, Tsuyoshi Morita, Mayu Miyagi and Yoshizo Matsuka : Dentin-pulp complex tissue regeneration via three-dimensional cell sheet layering, Tissue Engineering. Part C, Methods, Vol.27, No.10, 559-570, 2021. (Summary) The dentin-pulp complex is a unique structure in teeth that contains both hard and soft tissues. Generally, deep caries and trauma cause damage to the dentin-pulp complex, and if left untreated, this damage will progress to irreversible pulpitis. The aim of this study was to fabricate a layered cell sheet composed of rat dental pulp (DP) cells and odontogenic differentiation of pulp (OD) cells and to investigate the ability to regenerate the dentin-pulp complex in a scaffold tooth. We fabricated two single cell sheets composed of DP cells (DP cell sheet) or OD cells (OD cell sheet) and a layered cell sheet made by layering both cells. The characteristics of the fabricated cell sheets were analyzed using light microscopy, scanning electron microscope (SEM), hematoxylin-eosin (HE) staining, and immunohistochemistry (IHC). Furthermore, the cell sheets were transplanted into the subrenal capsule of immunocompromised mice for 8 weeks. After this, the regenerative capacity to form dentin-like tissue was evaluated using micro-computed tomography (micro-CT), HE staining, and IHC. The findings of SEM and IHC confirmed that layered cell sheets fabricated by stacking OD cells and DP cells maintained their cytological characteristics. Micro-CT of layered cell sheet transplants revealed a mineralized capping of the access cavity in the crown area, similar to that of natural dentin. In contrast, the OD cell sheet group demonstrated the formation of irregular fragments of mineralized tissue in the pulp cavity, and the DP cell sheet did not develop any hard tissue. Moreover, bone volume/tissue volume (BV/TV) showed a significant increase in hard tissue formation in the layered cell sheet group compared with that in the single cell sheet group ( < 0.05). HE staining also showed a combination of soft and hard tissue formation in the layered cell sheet group. Furthermore, IHC confirmed that the dentin-like tissue generated from the layered cell sheet expressed characteristic markers of dentin but not bone equivalent to that of a natural tooth. In conclusion, this study demonstrates the feasibility of regenerating dentin-pulp complex using a bioengineered tissue designed to simulate the anatomical structure. Impact statement The dentin-pulp complex can be destroyed by deep caries and trauma, which may cause pulpitis and progress to irreversible pulpitis, apical periodontitis, and even tooth loss. Current treatments cannot maintain pulp health, and teeth can become brittle. We developed a three-dimensional (3D) layered cell sheet using dental pulp cells and odontogenic differentiation of pulp cells for dentin-pulp complex regeneration. Our layered cell sheet enables the regeneration of an organized 3D dentin-pulp-like structure comparable with that of natural teeth. This layered cell sheet technology may contribute to dentin-pulp complex regeneration and provide a novel method for complex tissue engineering. (Tokushima University Institutional Repository) ● Metadata: 117029 (Link to Publication Site) ● Publication site (DOI): 10.1089/ten.TEC.2021.0171 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34583551 ● Search Scopus @ Elsevier (PMID): 34583551 ● Search Scopus @ Elsevier (DOI): 10.1089/ten.TEC.2021.0171 (Tokushima University Institutional Repository: 117029, DOI: 10.1089/ten.TEC.2021.0171, PubMed: 34583551)
3.	Rika Hayama, Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Takuma Iwasa, Junhel Dalanon, Raju Resmi, Omar Maningo Rodis and Yoshizo Matsuka : Longitudinal comparison between flipped classroom and team-based learning in a prosthodontic class, Journal of Oral Health and Biosciences, Vol.34, No.1, 1-10, 2021. (Summary) Active learning is a concept that allows students to study and learn actively by themselves to get knowledge. There are several methods of active learning, including flipped classroom (FC) and team-based learning (TBL). In FC, students are required to study before classes. In TBL, students also study before class, take individual readiness assurance test (iRAT) and team readiness assurance test (tRAT), then discuss group assignment projects (GAPs) during class. The purpose of this study was to compare the effectiveness between FC and TBL.<br> The effectiveness of FC and TBL was assessed from the results of the term-end examinations, questionnaires and practice examinations. To check the difficulty of the term-end examinations, control dentists took the same examinations and we calculated the equating score with item response theory.<br> Statistical analysis showed that the correct answer rate in term-end examinations was significantly different in comparison with the time of the trial, and for the participants (students and dentists). The term-end examination score of FC and TBL did not show a statistical difference. The student questionnaire showed that TBL had higher scores than FC on various factors such as student positive attitude, preparation, ingenuity of teacher and achieving the class goals. The crown & bridge score from the practice examination of 6<sup>th</sup>-year students who had FC + TBL were constantly higher than the Japanese national average score. The identification index of FC and TBL did not show the statistical difference and there was no statistical difference on item response theory between FC and TBL. (Keyword) Flipped classroom / Team-based learning / Prosthodontics (Tokushima University Institutional Repository) ● Metadata: 116284 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.34.1_1 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390852259674142080 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.34.1_1 (Tokushima University Institutional Repository: 116284, DOI: 10.20738/johb.34.1_1, CiNii: 1390852259674142080)
4.	Hiroo Kawahara, Miho Inoue, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka : Risk factors for tooth loss in patients with 25 remaining teeth undergoing mid-long-term, International Journal of Environmental Research and Public Health, Vol.18, No.13, 7174, 2021. (Tokushima University Institutional Repository) ● Metadata: 116124 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijerph18137174 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85109198478 (Tokushima University Institutional Repository: 116124, DOI: 10.3390/ijerph18137174, Elsevier: Scopus)
5.	Yoshizo Matsuka, Masamitsu Ohshima, Kazuo Okura, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi and Miho Inoue : インドネシアの歯学部における学部教育, The Journal of Japan Association of Oral Rehabilitation, Vol.33, No.1, 53-57, 2020. (Keyword) Undergraduate student education / dental school / Indonesia (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520572359516377600 (CiNii: 1520572359516377600)
6.	H Kawahara, Miho Inoue, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka : Risk factors for tooth loss in patients undergoing mid long-term maintenance: A retrospective study, International Journal of Environmental Research and Public Health, Vol.17, No.17, E6258, 2020. (Summary) In this retrospective study, we identified risk factors for tooth loss in patients undergoing mid-long-term maintenance therapy. We surveyed 674 maintenance patients for ≥5 years after active treatment who visited a dental clinic between January 2015 and December 2016. Of these, 265 were men (mean age 54.6 ± 8.0 years old) and 409 were women (mean age 54.0 ± 7.9 years old). Study variables included patient compliance, sex, number of teeth lost, cause of tooth loss (dental caries, periodontal disease, root fracture, others, vital or non-vital teeth), age at start of maintenance, number of remaining teeth at start of maintenance, smoking, use of salivary secretion inhibitors, presence of diabetes mellitus, condition of periodontal bone loss, and use of a removable denture. Most lost teeth were non-vital teeth (91.7% of all cases) and the most common cause of tooth loss was tooth fracture (62.1% of all cases). A statistically significant risk factors for tooth loss was number of remaining teeth at the start of maintenance ( = 0.003). (Tokushima University Institutional Repository) ● Metadata: 115160 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijerph17176258 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32867387 ● Search Scopus @ Elsevier (PMID): 32867387 ● Search Scopus @ Elsevier (DOI): 10.3390/ijerph17176258 (Tokushima University Institutional Repository: 115160, DOI: 10.3390/ijerph17176258, PubMed: 32867387)
7.	Resmi Raju, Masamitsu Ohshima, Miho Inoue, Tsuyoshi Morita, Yan Huijiao, Arief Waskitho, Otto Baba, Masahisa Inoue and Yoshizo Matsuka : Three-dimensional periodontal tissue regeneration using a bone-ligament complex cell sheet, Scientific Reports, Vol.10, No.1, 1656, 2020. (Summary) Periodontal tissue is a distinctive tissue structure composed three-dimensionally of cementum, periodontal ligament (PDL) and alveolar bone. Severe periodontal diseases cause fundamental problems for oral function and general health, and conventional dental treatments are insufficient for healing to healthy periodontal tissue. Cell sheet technology has been used in many tissue regenerations, including periodontal tissue, to transplant appropriate stem/progenitor cells for tissue regeneration of a target site as a uniform tissue. However, it is still difficult to construct a three-dimensional structure of complex tissue composed of multiple types of cells, and the transplantation of a single cell sheet cannot sufficiently regenerate a large-scale tissue injury. Here, we fabricated a three-dimensional complex cell sheet composed of a bone-ligament structure by layering PDL cells and osteoblast-like cells on a temperature responsive culture dish. Following ectopic and orthotopic transplantation, only the complex cell sheet group was demonstrated to anatomically regenerate the bone-ligament structure along with the functional connection of PDL-like fibers to the tooth root and alveolar bone. This study represents successful three-dimensional tissue regeneration of a large-scale tissue injury using a bioengineered tissue designed to simulate the anatomical structure. (Tokushima University Institutional Repository) ● Metadata: 114213 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-020-58222-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32015383 ● Search Scopus @ Elsevier (PMID): 32015383 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-020-58222-0 (Tokushima University Institutional Repository: 114213, DOI: 10.1038/s41598-020-58222-0, PubMed: 32015383)
8.	Takuma Iwasa, S Afroz, Miho Inoue, Rieko Arakaki, Masamitsu Ohshima, R Raju, Arief Waskitho, Inoue Masahisa, Otto Baba and Yoshizo Matsuka : IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain, Neuroscience Letters, Vol.703, 132-138, 2019. (Tokushima University Institutional Repository) ● Metadata: 113686 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neulet.2019.03.031 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.neulet.2019.03.031 (Tokushima University Institutional Repository: 113686, DOI: 10.1016/j.neulet.2019.03.031)
9.	Mio Naritani, Miho Inoue, Resmi Raju, Mayu Miyagi, Masamitsu Ohshima and Yoshizo Matsuka : Analysis of Bone Marrow-derived Mesenchymal Stem Cell Kinetics after Short-term Stimulation with Tumor Necrosis Factor-α (TNF-α), Journal of Hard Tissue Biology, Vol.28, No.2, 99-108, 2019. (Tokushima University Institutional Repository) ● Metadata: 113372 (Link to Publication Site) ● Publication site (DOI): 10.2485/jhtb.28.99 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85065527448 (Tokushima University Institutional Repository: 113372, DOI: 10.2485/jhtb.28.99, Elsevier: Scopus)
10.	S Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Otto Baba, Yoshihiro Okayama and Yoshizo Matsuka : CGRP induces differential regulation of cytokines from satellite glial cells in trigeminal ganglia and orofacial nociception, International Journal of Molecular Sciences, Vol.20, No.3, 711, 2019. (Summary) Neuron-glia interactions contribute to pain initiation and sustainment. Intra-ganglionic (IG) secretion of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) modulates pain transmission through neuron-glia signaling, contributing to various orofacial pain conditions. The present study aimed to investigate the role of satellite glial cells (SGC) in TG in causing cytokine-related orofacial nociception in response to IG administration of CGRP. For that purpose, CGRP alone (10 μL of 10 M), Minocycline (5 μL containing 10 μg) followed by CGRP with one hour gap (Min + CGRP) were administered directly inside the TG in independent experiments. Rats were evaluated for thermal hyperalgesia at 6 and 24 h post-injection using an operant orofacial pain assessment device (OPAD) at three temperatures (37, 45 and 10 °C). Quantitative real-time PCR was performed to evaluate the mRNA expression of IL-1β, IL-6, TNF-α, IL-1 receptor antagonist (IL-1RA), sodium channel 1.7 (NaV 1.7, for assessment of neuronal activation) and glial fibrillary acidic protein (GFAP, a marker of glial activation). The cytokines released in culture media from purified glial cells were evaluated using antibody cytokine array. IG CGRP caused heat hyperalgesia between 6-24 h (paired- test, < 0.05). Between 1 to 6 h the mRNA and protein expressions of GFAP was increased in parallel with an increase in the mRNA expression of pro-inflammatory cytokines IL-1β and anti-inflammatory cytokine IL-1RA and NaV1.7 (one-way ANOVA followed by Dunnett's post hoc test, < 0.05). To investigate whether glial inhibition is useful to prevent nociception symptoms, Minocycline (glial inhibitor) was administered IG 1 h before CGRP injection. Minocycline reversed CGRP-induced thermal nociception, glial activity, and down-regulated IL-1β and IL-6 cytokines significantly at 6 h (-test, < 0.05). Purified glial cells in culture showed an increase in release of 20 cytokines after stimulation with CGRP. Our findings demonstrate that SGCs in the sensory ganglia contribute to the occurrence of pain via cytokine expression and that glial inhibition can effectively control the development of nociception. (Tokushima University Institutional Repository) ● Metadata: 113687 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijms20030711 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30736422 ● Summary page in Scopus @ Elsevier: 2-s2.0-85061270594 (Tokushima University Institutional Repository: 113687, DOI: 10.3390/ijms20030711, PubMed: 30736422, Elsevier: Scopus)
11.	Miho Inoue, Mio Naritani, R Raju, Mayu Miyagi, Masamitsu Ohshima, Inoue Masahisa and Yoshizo Matsuka : Effect of short-term Tumour Necrosis Factor-alpha (TNF-α) -stimulation on the growth and differentiation of MC3T3-E1 osteoblast-like cells, Journal of Hard Tissue Biology, Vol.27, No.3, 213-218, 2018. (Tokushima University Institutional Repository) ● Metadata: 113362 (Link to Publication Site) ● Publication site (DOI): 10.2485/jhtb.27.213 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85049948297 (Tokushima University Institutional Repository: 113362, DOI: 10.2485/jhtb.27.213, Elsevier: Scopus)
12.	Keisuke Nishigawa, Rika Hayama, Ktsushi Omoto, Kazuo Okura, Toyoko Tajima, Yoshitaka Suzuki, Maki Hosoki, Mayu Miyagi, Miho Inoue, Omar Maningo Rodis and Yoshizo Matsuka : Validity of peer evaluation for team-based learning in a dental school in Japan, Journal of Dental Education, Vol.81, No.12, 1451-1456, 2017. (Summary) The aim of this study was to determine the validity of peer evaluation for team-based learning (TBL) classes in dental education in comparison with the term-end examination records and TBL class scores. Examination and TBL class records of 256 third- and fourth-year dental students in six fixed prosthodontics courses from 2013 to 2015 in one dental school in Japan were investigated. Results of the term-end examination during those courses, individual readiness assurance test (IRAT), group readiness assurance test (GRAT), group assignment projects (GAP), and peer evaluation of group members in TBL classes were collected. Significant positive correlations were found between all combinations of peer evaluation, IRAT, and term-end examination. Individual scores also showed a positive correlation with group score (total of GRAT and GAP). From the investigation of the correlations in the six courses, significant positive correlations between peer evaluation and individual score were found in four of the six courses. In this study, peer evaluation seemed to be a valid index for learning performance in TBL classes. To verify the effectiveness of peer evaluation, all students have to realize the significance of scoring the team member's performance. Clear criteria and detailed instruction for appropriate evaluation are also required. (Keyword) Education, Dental / Educational Measurement / Group Processes / Humans / Japan / Learning / Peer Group / Reproducibility of Results / Schools, Dental / Teaching (Tokushima University Institutional Repository) ● Metadata: 112932 (Link to Publication Site) ● Publication site (DOI): 10.21815/JDE.017.106 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29196333 ● Summary page in Scopus @ Elsevier: 2-s2.0-85038129509 (Tokushima University Institutional Repository: 112932, DOI: 10.21815/JDE.017.106, PubMed: 29196333, Elsevier: Scopus)
13.	Miho Inoue, KAWAHARA Hiroo, Kazuo Okura, Mayu Miyagi, NARITANI Mio, Takuma Iwasa, OMOTO Katsuhiro, Omar Maningo Rodis and Yoshizo Matsuka : Frequency of congenitally missing permanent teeth at a primary dental care clinic in Tokushima, Japan, The Journal of Japan Association of Oral Rehabilitation, Vol.30, No.1, 67-70, 2017. (Keyword) Congenitally missing permanent teeth / hypodontia / primary dental care (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520290884130282880 (CiNii: 1520290884130282880)

Proceeding of International Conference:

1.	S Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Otto Baba, Yoshihiro Okayama and Yoshizo Matsuka : CGRP induced glial-cytokine expression, NFkB signaling and orofacial nociception, International Association for Dental Research, Washington, D.C., Mar. 2020.
2.	R Raju, Masamitsu Ohshima, Tsuyoshi Morita, Huijiao Yan, Miho Inoue, Otto Baba, Masahisa Inoue and Yoshizo Matsuka : A double-layered complex cell sheet can regenerate the periodontal tissue in a mice model, Dentisphere, Surabayai, Nov. 2019.
3.	S Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Otto Baba, Yoshihiro Okayama and Yoshizo Matsuka : Orofacial nociception due to glial expressed cytokines in trigeminal ganglia, International Association for Dental Research, Vancouver, Jun. 2019.
4.	Iwasa Takuma, Rieko Arakaki, Oshima Masamitsu, S Afroz, Miho Inoue, Goto Nami, Naozumi Ishimaru and Yoshizo Matsuka : Up-regulation of inflammatory cytokines in trigeminal ganglia after infraorbital nerve constriction, The Journal of Neuroscience, Washington DC, Nov. 2017.

Proceeding of Domestic Conference:

1.	横井美有希, 安部倉仁, 森田晃司, 土井一矢, Maki Hosoki, Mayu Miyagi, Miho Inoue, Daisuke Ikutame, 中川晋輔, 秋山謙太郎, 縄稚久美子, 黒崎陽子, Yoshizo Matsuka, 窪木拓男 and 津賀一弘 : 最後方大臼歯へのPEEKクラウンの臨床応用についての6ヶ月間の評価, The Journal of the Japan Prosthodontic Society, Jul. 2024.
2.	Maki Hosoki, Toyoko Tajima, 宮城麻衣, Miho Inoue, Mariko Niki, Yoshiaki Kubo and Yoshizo Matsuka : 金属アレルギー患者におけるピアスによる皮膚障害の臨床的検討, 日本アレルギー学会, Oct. 2023.
3.	Eri Aoki, Yoshitaka Suzuki, SHINKAI Mizuki, Aya Ozawa, SHIBAGAKI Akari, TANIWAKI Tatsuya, Yasutomo Yoshihara, Kazuo Okura, Miho Inoue, 池田隆志, Masamitsu Ohshima and Yoshizo Matsuka : 睡眠体位療法による睡眠時ブラキシズムへの効果の検討, 日本補綴学会中国四国支部学術大会, Sep. 2023.
4.	柴垣あかり, Yoshitaka Suzuki, FUKUTA Momo, 神野青空, 新開瑞希, OZAWA Aya, 青木映璃, 谷脇竜弥, Kazuo Okura, Miho Inoue, G. Lavigne and Yoshizo Matsuka : 睡眠体位療法の睡眠時ブラキシズムへの効果予測の検討, Shikoku Dental Research, Jul. 2023.
5.	Aya Ozawa, Yoshitaka Suzuki, Toyoko Tajima, Toshinori Okawa, Kouhei Kamoi, Kazuo Okura, 谷脇竜弥, Miho Inoue, 吉原靖智, Masamitsu Ohshima, Susumu Abe and Yoshizo Matsuka : 睡眠時ブラキシズム患者の適応したアプライアンスの変形を長期間観察した症例, The Journal of the Japan Prosthodontic Society, May 2023.
6.	Miho Inoue, Masamitsu Ohshima, Mayu Miyagi, Daisuke Ikutame and Yoshizo Matsuka : 口腔顔面痛はアロマテラピーで軽減する∼口腔顔面痛モデル動物での評価∼, The Journal of the Japan Prosthodontic Society, May 2023.
7.	Maki Hosoki, Daisuke Ikutame, Mayu Miyagi, Kazuo Okura, Miho Inoue, OZAWA Aya, SHIBAGAKI Akari, TANIWAKI Tatsuya, Kouhei Kamoi, 伸幸板東, Yasutomo Yoshihara, Masamitsu Ohshima, Yoshitaka Suzuki, SHINKAI Mizuki and Yoshizo Matsuka : デジタル化に対応したクラウンブリッジ補綴学実習の検討, The Journal of the Japan Prosthodontic Society, May 2023.
8.	蓮池真由子, Miho Inoue, RAMAN SWARNA LAKSHMI, Jaime M.Fabillar, Lutfi P.Perdana, Mayu Miyagi, Daisuke Ikutame, Masamitsu Ohshima and Yoshizo Matsuka : 口腔顔面痛モデル動物を用いた精油嗅覚刺激の疼痛抑制効果∼ベルガモット，ラベンダーの検討∼, Shikoku Dental Research, Mar. 2023.
9.	Miho Inoue, RAMAN SWARNA LAKSHMI, FABILLAR JR. JAIME MORENO, 蓮池真由子, PERDANA LUTFI PUTRA, 井上正久, Daisuke Ikutame, Mayu Miyagi, Masamitsu Ohshima and Yoshizo Matsuka : 精油成分による口腔顔面痛モデル動物の痛み軽減とメカニズム, 徳島大学脳科学クラスター・ミニリトリート, Feb. 2023.
10.	Maki Hosoki, Daisuke Ikutame, Mayu Miyagi, Kazuo Okura, Miho Inoue, OZAWA Aya, SHIBAGAKI Akari, TANIWAKI Tatsuya, Kouhei Kamoi, 伸幸板東, C. Riquelme, Yasutomo Yoshihara, Masamitsu Ohshima, Yoshitaka Suzuki, 新開みずき and Yoshizo Matsuka : デジタル化が進む歯科診療の現状紹介と歯科補綴学実習における学習内容の検討, 大学教育カンファレンスin徳島, Dec. 2022.
11.	Maki Hosoki, Toyoko Tajima, Mayu Miyagi, Miho Inoue, Yoshiaki Kubo and Yoshizo Matsuka : 装飾品に対するニッケル表示の標準化をめざした取り組みについて, 日本皮膚免疫アレルギー学会, Dec. 2022.
12.	Kazuo Okura, Miho Inoue, Yoshitaka Suzuki, Maki Hosoki, Daisuke Ikutame, Susumu Abe, Fumiaki Kawano and Yoshizo Matsuka : アクティブラーニングの学修効果 ―オンライン授業と通常授業，TBL授業の比較―, The Journal of Japanese Dental Education Association, Jul. 2022.
13.	Maki Hosoki, Kazuo Okura, Miho Inoue, Yoshitaka Suzuki, Daisuke Ikutame, Susumu Abe, Fumiaki Kawano and Yoshizo Matsuka : 2021年度歯科補綴学実習の評価, The Journal of Japanese Dental Education Association, Jul. 2022.
14.	Toyoko Tajima, Maki Hosoki, Miho Inoue, Aya Ozawa, Mizuki Shinkai, Mayu Miyagi, Mio Naritani, Masamitsu Ohshima, 杉尾隆夫, 山本伊一郎 and Yoshizo Matsuka : 徳島大学病院における歯科用金属アレルギー患者の臨床統計学的検討, The Journal of the Japan Prosthodontic Society, Jul. 2022.
15.	SHINKAI Mizuki, Maki Hosoki, Yoshitaka Suzuki, Toyoko Tajima, Miho Inoue, OZAWA Aya, Yasutomo Yoshihara, Masamitsu Ohshima, 織田英正, 本田常晴 and Yoshizo Matsuka : レジンアレルギーのリスクと歯科治療における対応, The Journal of the Japan Prosthodontic Society, Jul. 2022.
16.	Kazuo Okura, Rika Hayama, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Daisuke Ikutame, Toyoko Tajima, Yasutomo Yoshihara, Aya OZAWA, SHINKAI Mizuki and Yoshizo Matsuka : 歯科補綴学におけるアクティブラーニングの学修効果反転授業とTBL，通常授業の比較, The Journal of the Japan Prosthodontic Society, Jul. 2022.
17.	Kazuo Okura, Rika Hayama, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Miho Inoue, Daisuke Ikutame, Yasutomo Yoshihara, SHINKAI Mizuki, OZAWA Aya and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの学修効果―オンライン授業と通常授業，TBL授業の比較―, 大学教育カンファレンス in 徳島, Jan. 2022.
18.	Maki Hosoki, Yasufumi Nishikawa, Daisuke Ikutame, Masamitsu Ohshima, Miho Inoue, Aya OZAWA, SHINKAI Mizuki, RAMAN SWARNA LAKSHMI, CHAVAN PARIMAL RAVINDRA, Yasutomo Yoshihara, Kazuo Okura, Yoshitaka Suzuki and Yoshizo Matsuka : COVID-19対策が日常となった2021年度歯科補綴学実習の評価, 大学教育カンファレンス in 徳島, Jan. 2022.
19.	Kazuo Okura, Miho Inoue, Yoshitaka Suzuki, Maki Hosoki, Susumu Abe, Fumiaki Kawano and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの導入とその学習効果 ―オンライン授業とTBL授業の比較―, The Journal of Japanese Dental Education Association, Nov. 2021.
20.	Maki Hosoki, Kazuo Okura, Miho Inoue, Yoshitaka Suzuki, Susumu Abe, Fumiaki Kawano and Yoshizo Matsuka : コロナ禍におけるデジタル機器およびウェブを利用した歯科補綴学実習の評価, The Journal of Japanese Dental Education Association, Nov. 2021.
21.	Maki Hosoki, Yuehui Zhang, Toyoko Tajima, Miho Inoue, 井上正久, Masamitsu Ohshima, Mayu Miyagi and Yoshizo Matsuka : モデルマウスによるチタンアレルギーの検討, Journal of the Japanese Association for Dental Science, Sep. 2021.
22.	Yasutomo Yoshihara, Yoshitaka Suzuki, Kazuo Okura, Shuji Shigemoto, Susumu Abe, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Eiichi Bando and Yoshizo Matsuka : 顎運動を伴うRMMAの三次元顎運動解析を行った症例, The Journal of the Japan Prosthodontic Society, Jun. 2021.
23.	Yuehui Zhang, Maki Hosoki, Masamitsu Ohshima, Mayu Miyagi, 成谷美緒, Miho Inoue and Yoshizo Matsuka : 金属アレルギー患者群と健常者群における特異的マイクロRNAの同定, The Journal of the Japan Prosthodontic Society, Jun. 2021.
24.	Masamitsu Ohshima, Raju Resmi, Yan Huijiao, Miho Inoue and Yoshizo Matsuka : 骨‐歯根膜線維の複合組織立体形成による歯周組織再生技術の開発, 第20回日本再生医療学会総会, Mar. 2021.
25.	Rika Hayama, Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Omar Maningo Rodis, Junhel Dalanon, Raju Resmi and Yoshizo Matsuka : 補綴学授業における反転授業とTBLの学修効果に関する比較, Shikoku Dental Research, Feb. 2021.
26.	Masamitsu Ohshima, Raju Resmi, Yan Huijiao, Miho Inoue and Yoshizo Matsuka : 骨‐歯根膜線維の複合組織立体形成による歯周組織再生技術の開発, 日本再生医療学会, Feb. 2021.
27.	Maki Hosoki, Kazuo Okura, Masamitsu Ohshima, Yasufumi Nishikawa, Raju Resmi, OZAWA Aya, SHINKAI Mizuki, Arief Waskitho, RAMAN SWARNA LAKSHMI, CHAVAN PARIMAL RAVINDRA, Miho Inoue, Yoshitaka Suzuki, 吉原靖智 and Yoshizo Matsuka : 歯科補綴学実習における新型コロナウイルス感染症対策について, 大学教育カンファレンス in 徳島, Jan. 2021.
28.	Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Miho Inoue, Yasutomo Yoshihara and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの学修効果―オンライン授業とTBL授業の比較―, 大学教育カンファレンス in 徳島, Jan. 2021.
29.	Maki Hosoki, Yuehui Zhang, Miho Inoue, 井上正久 and Yoshizo Matsuka : チタンアレルギーモデルマウスの作製と免疫担当細胞の病理組織学的検討, 日本皮膚免疫アレルギー学会, Dec. 2020.
30.	Maki Hosoki, Kazuo Okura, Miho Inoue, Yoshitaka Suzuki, Susumu Abe, Fumiaki Kawano and Yoshizo Matsuka : 新型コロナウイルス感染症対策を踏まえた冠橋義歯学実習の検討, The Journal of Japanese Dental Education Association, Sep. 2020.
31.	Kazuo Okura, Miho Inoue, Yoshitaka Suzuki, Maki Hosoki, Fumiaki Kawano and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの導入とその学習効果 ―通常授業，TBL，反転授業の比較―, The Journal of Japanese Dental Education Association, Sep. 2020.
32.	Masamitsu Ohshima, Raju Resmi, Miho Inoue, Mayu Miyagi and Yoshizo Matsuka : 骨‐歯根膜線維の複合組織形成による三次元組織再生技術の開発, 公益社団法人日本補綴歯科学会第129回学術大会, Jun. 2020.
33.	Takuma Iwasa, Miho Inoue, Raju Resmi, Masamitsu Ohshima and Yoshizo Matsuka : IL-10は神経障害性疼痛を抑制する, The Journal of the Japan Prosthodontic Society, Jun. 2020.
34.	Maki Hosoki, Zhang Yuehui, Masamitsu Ohshima, Miho Inoue, Mio Naritani, Mayu Miyagi and Yoshizo Matsuka : 血中マイクロRNAを介した金属アレルギーの感作・発症機序の解明, Journal of the Japanese Association for Dental Science, Vol.39, 58, Mar. 2020.
35.	Rika Hayama, Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Omar Marianito, Takuma Iwasa and Yoshizo Matsuka : 補綴学授業におけるアクティブラーニングによる学修効果-反転授業とTBLの長期比較-, 徳島県歯科医学大会, Feb. 2020.
36.	Takuma Iwasa, Afroz Shaista, Miho Inoue, Rieko Arakaki, Masamitsu Ohshima, Raju Resmi, Arief Waskitho, 井上正久, Otto Baba and Yoshizo Matsuka : 痛みに対するサイトカイン療法の開発に向けて, 徳島県歯科医学大会, Feb. 2020.
37.	Maki Hosoki, Miho Inoue, Takuma Iwasa, Yasufumi Nishikawa, 秋月皆人, 吉原靖智, Kazuo Okura, Yuehui Zhang, Huijiao Yan, Waskitho Arief, Ofuchi R.S., Masamitsu Ohshima, Yoshitaka Suzuki, 成谷美緒, Mayu Miyagi, Raju Resmi and Yoshizo Matsuka : 歯科補綴学(Ⅱ)実習における実習書改定後の検討, 大学教育カンファレンスin徳島, Dec. 2019.
38.	Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Takuma Iwasa and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの学修効果―反転授業とTBL，通常授業の比較―, 大学教育カンファレンスin徳島, Dec. 2019.
39.	Raju Resmi, Masamitsu Ohshima, Miho Inoue, Tsuyoshi Morita, Yan Huijiao, Otto Baba, Inoue Masahisa and Yoshizo Matsuka : Development of a multilayered complex cell sheet to regenerate periodontal tissue, Tokushima University Bioscience Retreat, Sep. 2019.
40.	Yuehui Zhang, Maki Hosoki, Masamitsu Ohshima, Mayu Miyagi, 成谷美緒, Miho Inoue and Yoshizo Matsuka : 金属アレルギー患者群と健常者群における特異的マイクロRNAの同定, 日本補綴歯科学会中国・四国支部学術大会, Sep. 2019.
41.	成谷美緒, Maki Hosoki, Mayu Miyagi, Masamitsu Ohshima, Miho Inoue, 岩浅匠真 and Yoshizo Matsuka : 金属アレルギー患者に対する血管内治療の術前評価, 日本補綴歯科学会中国・四国支部学術大会, Sep. 2019.
42.	Maki Hosoki, Yuehui Zhang, Masamitsu Ohshima, Miho Inoue, 成谷美緒, Mayu Miyagi and Yoshizo Matsuka : 血中マイクロRNAを介した金属アレルギーの感作・発症機序の解明, 歯科医学を中心とした総合的な研究を推進する集い, Aug. 2019.
43.	Raju Resmi, Masamitsu Ohshima, Miho Inoue, Tsuyoshi Morita, Yan Huijiao, Otto Baba, 井上正久 and Yoshizo Matsuka : 骨芽細胞と歯根膜細胞との立体形成複合細胞シートによる歯周組織再生の確立, 硬組織再生生物学会, Aug. 2019.
44.	Kazuo Okura, Miho Inoue, Maki Hosoki, Fumiaki Kawano and Yoshizo Matsuka : 卒前専門基礎教育におけるアクティブラーニングの導入とその学習効果―反転授業とTBLの比較―, The Journal of Japanese Dental Education Association, Jul. 2019.
45.	Miho Inoue, Raju Resmi, Takuma Iwasa, 秋山謙太郎, Masamitsu Ohshima, 窪木拓男 and Yoshizo Matsuka : 抗Dickkopf1 (DKK-1) 抗体による骨分化能メカニズムの解明, The Journal of the Japan Prosthodontic Society, May 2019.
46.	Maki Hosoki, Miho Inoue, Takuma Iwasa, Yasufumi Nishikawa, 秋月皆人, Yasutomo Yoshihara, Kazuo Okura, Yuehui Zhang, Huijiao Yan, Arief Waskitho, Rodrigo Shigeru Ofuchi, Masamitsu Ohshima, Yoshitaka Suzuki, 成谷美緒, Mayu Miyagi, Raju Resmi and Yoshizo Matsuka : 歯科補綴学(Ⅱ)実習における実習書改定後の検討in徳島, 大学教育カンファレンス, Dec. 2018.
47.	Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, 岩浅匠真, Junhel Dalanon and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの学修効果-反転授業とTBLの比較-, 大学教育カンファレンスin徳島, Dec. 2018.
48.	Maki Hosoki, Mayu Miyagi, Miho Inoue, Kazuo Okura, Masamitsu Ohshima, Raju Resmi, 岩浅匠真, 成谷美緒, Zhang Yuehui, Yan Huijiao, Arief Waskitho, Junhel Dalanon, Yoshitaka Suzuki, 吉原靖智 and Yoshizo Matsuka : 歯科補綴学実習における実習書の改訂とその効果の検討, 大学教育カンファレンスin徳島, Dec. 2018.
49.	川原博雄, Miho Inoue, Masamitsu Ohshima, Kazuo Okura, Maki Hosoki, Toyoko Tajima and Yoshizo Matsuka : 一般歯科診療所での長期メインテナンス患者における歯の喪失原因の評価, 日本補綴歯科学会中国・四国支部学術大会, Sep. 2018.
50.	Raju Resmi, Miho Inoue, 宮城麻友, 秋山謙太郎, Masamitsu Ohshima, 井上正久 and Yoshizo Matsuka : 抗Dickkopf1 (DKK-1) 抗体による骨髄細胞の骨分化能への影響, 硬組織再生生物学会, Aug. 2018.
51.	Miho Inoue, Raju Resmi, Masamitsu Ohshima, 梶本昇, 都留寛治, 石川邦夫, 井上正久 and Yoshizo Matsuka : Tumor necrosis factor (TNF)-α処理炭酸アパタイトおよびハイドロキシアパタイトが骨形成におよぼす影響, 硬組織再生生物学会, Aug. 2018.
52.	岩浅匠真, Afroz Shaista, Casinilo Junhel Dalanon, Masamitsu Ohshima, Kazuo Okura, Miho Inoue and Yoshizo Matsuka : 三叉神経痛モデルラットにおける炎症性サイトカインの変動解析, 日本顎関節学会・日本口腔顔面痛学会・日本歯科心身医学会, Jul. 2018.
53.	Kouhei Kamoi, Yoshitaka Suzuki, Kazuo Okura, 宮城麻友, Miho Inoue, Masamitsu Ohshima, Yuji Shimizu and Yoshizo Matsuka : ナイトガードの咬耗面を3次元画像解析装置にて定量評価した症例, Shikoku Dental Research, Mar. 2018.
54.	Kazuo Okura, Keisuke Nishigawa, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, 宮城麻友, Miho Inoue, Takuma Iwasa, Rika Hayama and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの効果 ―反転授業とTBLの比較―, 教育カンファレンスin徳島, Dec. 2017.
55.	S Afroz, Iwasa Takuma, Masamitsu Ohshima, Rieko Arakaki, Miho Inoue, Naozumi Ishimaru and Yoshizo Matsuka : Cytokine released by satellite glial cells and pain transmission in sensory ganglions, Japan Association for Dental Research, Nov. 2017.
56.	Hiroh Kawahara, Miho Inoue, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka : 長期的メインテナンス患者における歯の喪失に関する後ろ向き調査, The Journal of Japan Association of Oral Rehabilitation, Nov. 2017.
57.	Takuma Iwasa, S. Afroz, Mio Naritani, 宮城麻友, Miho Inoue, Masamitsu Ohshima and Yoshizo Matsuka : 神経障害性痛モデルラットに対するボツリヌス毒素の効果, 日本ボツリヌス治療学会, Sep. 2017.
58.	Raju Resmi, Miho Inoue, Mio Naritani, 宮城麻友, 織田英正, 友永泰弘, Masamitsu Ohshima and Yoshizo Matsuka : 骨髄由来間葉系細胞におけるTNF-α短期刺激による細胞動態の解析, 日本補綴歯科学会中国四国支部学術大会, Aug. 2017.
59.	Miho Inoue, Mio Naritani, R. Raju, 宮城麻友, Y. Zhang, Masamitsu Ohshima, 井上正久 and Yoshizo Matsuka : 骨髄細胞，骨芽細胞様細胞におけるTNF-α短期間刺激による細胞挙動の解析, 日本硬組織再生生物学会, Aug. 2017.
60.	Takuma Iwasa, Masamitsu Ohshima, Kazuo Okura, Miho Inoue, S. Afroz and Yoshizo Matsuka : 口腔顎顔面痛モデル三叉神経節におけるサイトカイン動態, Japanese Journal of Orofacial Pain, Jul. 2017.
61.	Daiki Teruya, Miho Inoue, Mio Naritani, R. Raju, 宮城麻友, Masamitsu Ohshima and Yoshizo Matsuka : 骨髄細胞，骨芽細胞様細胞におけるTNF-α短期刺激による細胞学的・組織学的検討, The Journal of the Japan Prosthodontic Society, Jul. 2017.
62.	Daiki Teruya, Miho Inoue, Mio Naritani, R. Raju, 宮城麻友, Masamitsu Ohshima and Yoshizo Matsuka : TNF-α短期刺激による骨髄細胞の細胞学的検討, Shikoku Dental Research, Jun. 2017.
63.	Miho Inoue, Mio Naritani, R. Raju, Mayu Miyagi and Yoshizo Matsuka : 腫瘍壊死因子TNF-αによる歯髄細胞，骨髄細胞の幹細胞化, 徳島大学大学院医歯薬学研究部発生・再生・遺伝クラスター・ミニリトリート, Mar. 2017.
64.	Yoshizo Matsuka, Takuma Iwasa, S. Afroz, Katsuhiro Ohmoto, Miho Inoue, Mio Naritani, Mayu Miyagi and Kazuo Okura : 末梢知覚神経節における神経伝達物質による痛み情報伝達, 徳島大学医歯薬学研究部脳科学クラスター・ミニリトリート, Mar. 2017.
65.	Kazuo Okura, Keisuke Nishigawa, Maki Hosoki, Toyoko Tajima, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, 大本勝弘, 葉山莉香 and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの効果 ―反転授業とTBLの比較―, 大学教育再生加速プログラムシンポジウム, Dec. 2016.
66.	藤枝創, Maki Hosoki, Keisuke Nishigawa, Miho Inoue, 中川敬司, Kouhei Kamoi, takayoshi oshio, 宮本裕司 and Yoshizo Matsuka : ジルコニア切削方法の違いが強度におよぼす影響について, 日本補綴歯科学会九州,中国・四国支部学術大会, Sep. 2016.
67.	Mayu Miyagi, Miho Inoue, 福本美緒 and Yoshizo Matsuka : 炎症環境による歯髄細胞の幹細胞化―歯髄細胞分化に与える TNF-αの影響―, The Journal of Japanese Society of Stomatognathic Function, Apr. 2016.
68.	Yoshizo Matsuka, 大本勝弘, 岩浅匠真, Miho Inoue, 福本美緒, Mayu Miyagi and Kazuo Okura : 知覚神経節における神経伝達物質による痛み情報伝達の可能性, The Journal of Japanese Society of Stomatognathic Function, Apr. 2016.

Et cetera, Workshop:

1.	Raju Resmi, Masamitsu Ohshima, Tsuyoshi Morita, Yan Huijiao, Miho Inoue, Otto Baba, Inoue Masahisa and Yoshizo Matsuka : Three-dimensional periodontal tissue regeneration using a bone-ligament complex cell sheet, 発生・再生・遺伝クラスターミニリトリート, Feb. 2020.
2.	Resmi Raju, Miho Inoue, M. Naritani, Mayu Miyagi, Yuehui Zhang, Masamitsu Oshima, Masahisa Inoue and Yoshizo Matsuka : Cellular kinetics of bone marrow derived mesenchymal cells by short-term TNF-alpha stimulation, Tokushima University Bioscience Retreat, Sep. 2017.
3.	S. Afroz, Iwasa Takuma, Oshima Masamitsu, Rieko Arakaki, Miho Inoue, Naozumi Ishimaru and Yoshizo Matsuka : Cytokine release from satellite glial cells of trigeminal ganglia, Tokushima University Bioscience Retreat, Sep. 2017.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Elucidate of mechanism of orofacial pain through pain reduction using essential oils in neuropathic pain animal model (Project/Area Number: 22K10060 )
microRNAを用いた金属アレルギーによる口腔扁平苔癬の新規診断マーカーの確立 (Project/Area Number: 21K10022 )
Establishment of the new diagnosis biomarkers for metal allergy by analyzing peripheral blood miRNA expression (Project/Area Number: 20K10038 )
Development of a bio-artificial tooth root based on the mechanism for periodontal tissue formation and maturation by using occlusal stress. (Project/Area Number: 19K10208 )
Investigation of mechanism for anti DKK-1 antibody possessing bone formation (Project/Area Number: 17K11753 )
Development of a novel therapy based on stem cell conversion of dental pulp cells (Project/Area Number: 16K11600 )
Metal allergy; What is the difference between sensitization and onset? -Identification of specific genes- (Project/Area Number: 16K11599 )
The development of new baiomaterial promoted regeneration of a dental pulp and odontoblast. (Project/Area Number: 15H06450 )
Molecular biological analysis of oral bacterial population dynamics (Project/Area Number: 10671699 )
Development of inhibitors for a angiogenesis factor CTGF and its application for angiogenetic diseases (Project/Area Number: 10557165 )
Molecular cloning of the receptors for chondrosarcoma-derived chondrocyte growth factor Ecogenin/CTGF (Project/Area Number: 09671893 )
Ecological analysis of Helicobacter pylori in oral cavities (Project/Area Number: 08672069 )
若年性歯周病原性細菌が産生する白血球毒素蛋白質の機能領域の同定 (Project/Area Number: 07771611 )
Function and structure of glucosyltransferase of Streptococcus sobrinus (Project/Area Number: 06671811 )
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Assistant Professor : Inoue, Miho

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)