徳島大学 / 教育研究者総覧 --- 福田直志

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https://researchmap.jp/naoyukifukuda (researchmap)

専門分野

○	ライフサイエンス (Life sciences) [外科系歯学 (Surgical dentistry)]

研究テーマ

著書・論文

学術論文(審査論文):

1.	Akira Takahashi, Kumiko Kamada, Naoyuki Fukuda, Keiko Kudoh, Natsumi Takamaru, Naito Kurio, Chieko Sugawara and Youji Miyamoto : Analysis of the sublingual artery using contrast-enhanced computed tomography, Clinical Implant Dentistry and Related Research, Vol.25, No.3, 532-539, 2023. (要約) This in vivo study aimed to clarify the position of the sublingual artery (SLA) relative to the mandibular bone and to infer the potential risk for injury during dental implant surgery. Contrast-enhanced computed tomography images of the mouth of 50 edentulous patients (100 sides) treated at Tokushima University Hospital were reviewed. Curved planar reconstructed images perpendicular to the alveolar ridge were processed and classified into molar, premolar, canine, and incisor regions. The SLA and its branches were identified, and the distance from the mandible to the SLA was measured. The SLA was located close to the mandible (<2 mm) in the molar, premolar, canine, and incisor segments in 12.0% (95% confidence interval 5.6%-18.4%), 20.6% (12.6%-28.7%), 30.5% (21.3%-39.8%), and 41.8% (28.8%-54.9%) cases, respectively. The SLA was located within ±3 mm craniocaudally to the upper wall of the mandibular canal in the molar and premolar regions in 50% of cases and within ±5 mm craniocaudally to the mylohyoid ridge in the canine and incisor regions in the other cases, with no sex or age-related differences. The vertical distance from the alveolar ridge to the SLA was influenced by sex and age owing to alveolar resorption, indicating that the alveolar ridge is not a reliable reference for predicting SLA position. As the risk of SLA injury always exist during dental implant placement and there is no way to confirm the SLA pathways in a patient, clinicians must avoid injuring the sublingual soft tissue. (キーワード) Dental Implants / Mandible / Alveolar Process / Tomography, X-Ray Computed / Cone-Beam Computed Tomography / Arteries (出版サイトへのリンク) ● Publication site (DOI): 10.1111/cid.13197 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36896477 ● Search Scopus @ Elsevier (PMID): 36896477 ● Search Scopus @ Elsevier (DOI): 10.1111/cid.13197 (DOI: 10.1111/cid.13197, PubMed: 36896477)
2.	福田直志, 髙丸菜都美, 秋田和也, 浦田豊彰, 永井和弘, 宮本洋二 : 舌骨近傍に移動した舌内迷入魚骨の1例, 日本口腔外科学会雑誌, Vol.68, No.2, 58-62, 2023年. (キーワード) 魚骨 / 異物 / 舌 / 舌骨 / 術中超音波検査 / fishbone / foreign body / tongue / hyoid bone / intraoperative ultrasonography (出版サイトへのリンク) ● Publication site (DOI): 10.5794/jjoms.69.58 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390295823371025920 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.69.58 (DOI: 10.5794/jjoms.69.58, CiNii: 1390295823371025920)
3.	Naoyuki Fukuda, Keiko Kudoh, Kazuya Akita, Natsumi Takamaru, 石川邦夫 and Youji Miyamoto : Comparison of bioresorbable bone substitutes, carbonate apatite and β-tricalcium phosphate, for alveolar bone augmentation with simultaneous implant placement., Oral Science International, Vol.20, No.2, 1-8, 2023. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/osi2.1170 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1002/osi2.1170 (DOI: 10.1002/osi2.1170)
4.	Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Natsumi Takamaru, Naito Kurio, 石川邦夫 and Youji Miyamoto : Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure., Journal of Materials Science. Materials in Medicine, Vol.34, No.1, 2022. (要約) Carbonate apatite (COAp) granules are useful as a bone substitute because they can be remodeled to new natural bone in a manner that conforms to the bone remodeling process. However, reconstructing large bone defects using COAp granules is difficult because of their granular shape. Therefore, we fabricated COAp honeycomb blocks (HCBs) with continuous unidirectional pores. We aimed to elucidate the tissue response and availability of COAp HCBs in the reconstruction of rabbit mandibular bone defects after marginal mandibulectomy. The percentages of the remaining COAp area and calcified bone area (newly formed bone) were estimated from the histological images. COAp area was 49.1 ± 4.9%, 30.3 ± 3.5%, and 25.5 ± 8.8%, whereas newly formed bone area was 3.0 ± 0.6%, 24.3 ± 3.3%, and 34.7 ± 4.8% at 4, 8, and 12 weeks, respectively, after implantation. Thus, COAp HCBs were gradually resorbed and replaced by new bone. The newly formed bone penetrated most of the pores in the COAp HCBs at 12 weeks after implantation. By contrast, the granulation tissue scarcely invaded the COAp HCBs. Some osteoclasts invaded the wall of COAp HCBs, making resorption pits. Furthermore, many osteoblasts were found on the newly formed bone, indicating ongoing bone remodeling. Blood vessels were also formed inside most of the pores in the COAp HCBs. These findings suggest that COAp HCBs have good osteoconductivity and can be used for the reconstruction of large mandibular bone defects. The COAp HCB were gradually resorbed and replaced by newly formed bone. (キーワード) Animals / Rabbits / Porosity / Apatites / Bone Substitutes / Bone and Bones / Porifera (徳島大学機関リポジトリ) ● Metadata: 118064 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10856-022-06710-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36586041 ● Summary page in Scopus @ Elsevier: 2-s2.0-85145354870 (徳島大学機関リポジトリ: 118064, DOI: 10.1007/s10856-022-06710-2, PubMed: 36586041, Elsevier: Scopus)
5.	山村佳子, 福井誠, 工藤隆治, 横田美保, 鎌田久美子, 秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 栗尾奈愛, 宮本洋二 : ピロカルピン塩酸塩を用いた口腔リンス法の有用性と安全性の検討, 日本口腔ケア学会誌, Vol.16, No.2, 52-56, 2022年.
6.	Naoyuki Fukuda, Kunio Ishikawa and Youji Miyamoto : Alveolar ridge preservation in beagle dogs using carbonate apatite bone substitute, Ceramics International, Vol.48, No.2, 1796-1804, 2022. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ceramint.2021.09.260 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85116543247 (DOI: 10.1016/j.ceramint.2021.09.260, Elsevier: Scopus)
7.	Natsumi Takamaru, Naoyuki Fukuda, Kazuya Akita, Keiko Kudoh and Youji Miyamoto : Association of PD L1 and ZEB 1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma, Oncology Letters, Vol.23, No.3, 2022. (要約) Programmed cell death-1 (PD-1) and its ligand programmed cell death 1 ligand 1 (PD-L1) are immune checkpoint inhibitors that play an important role in the host immune avoidance mechanism of tumors. The relationship between PD-L1 expression and malignancy has been reported in various types of cancer, such as lung and gastric cancer. In addition, epithelial-mesenchymal transition (EMT) of cancer cells is deeply involved in the invasion and metastasis of cancer. It has been reported that zinc finger E-box binding homeobox 1 (ZEB-1), an EMT inducer, contributes to metastasis in pancreatic and colon cancer. The present study aimed to investigate the relationship between the expression patterns of two markers, PD-L1 and ZEB-1, and clinicopathological characteristics and prognosis of oral squamous cell carcinoma (OSCC). Biopsy or surgical excision specimens from 169 patients with OSCC were used in the present study. Immunohistochemical staining with monoclonal anti-PD-L1 antibody and anti-ZEB-1 antibody was conducted. Cases with >1% tumor cells positive for PD-L1 and those with >10% tumor cells positive for ZEB-1 were considered positive, respectively. The findings revealed that individual expression of PD-L1 and ZEB-1 in OSCC was not associated with tumor size, degree of differentiation or Yamamoto-Kohama invasion pattern classification. However, co-expression of PD-L1 and ZEB-1 was associated with higher cervical lymph node metastasis and a lower survival rate. In conclusion, the results of the present study indicated that co-expression of PD-L1 and ZEB-1 could serve as a potential marker for the prognosis of patients with OSCC. (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ol.2022.13195 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35111244 ● Summary page in Scopus @ Elsevier: 2-s2.0-85123294766 (DOI: 10.3892/ol.2022.13195, PubMed: 35111244, Elsevier: Scopus)
8.	Y Ogino, Y Ayukawa, N Tachikawa, M Shimogishi, Youji Miyamoto, Keiko Kudoh, Naoyuki Fukuda, K Ishikawa and K Koyano : Staged Sinus Floor Elevation Using Novel Low-Crystalline Carbonate Apatite Granules: Prospective Results after 3-Year Functional Loading., Materials, Vol.14, No.19, 5760, 2021. (徳島大学機関リポジトリ) ● Metadata: 116822 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ma14195760 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85116466459 (徳島大学機関リポジトリ: 116822, DOI: 10.3390/ma14195760, Elsevier: Scopus)
9.	山村佳子, 眞野隆充, 鎌田久美子, 横田美保, 福田直志, 髙丸菜都美, 工藤景子, 栗尾奈愛, 宮本洋二 : 口腔領域に発症した悪性リンパ腫の臨床的検討, 日本口腔腫瘍学会誌, Vol.33, No.2, 35-60, 2021年. (要約) 2008年から2018年までの11年間に当科で口腔領域に発症した悪性リンパ腫の18例について臨床的特徴を調べた．患者は，平均年齢が70.2歳の男性10例，女性8例であった．原発部位の10例(55.6%)は上顎歯肉で，初期症状は15例(83.3%)で腫瘤と腫脹であった．7例(38.9%)が初診時に臨床的に悪性リンパ腫と診断されたが，その他の11例は正しく診断することが困難であった．腫瘤形成や潰瘍のような様々な臨床症状が診断を困難にしており，1回の生検では確定診断が得られなかった．そこで，血液検査値が診断の指標であるかどうかを検討した．われわれの結果は，17例中8例のLDH(47.1%)と16例中11例のsIL-2R(68.8%)が高い値を示していた．さらに，われわれはリンパ球/単球数比(LMR)が診断に役立つかどうかを調べた．LMRの値は，17例中13例(76.5%)が有意に低く，非ML患者と比較しても有意差を認めた．以上のことより，LMRの血液検査も診断の補助的なマーカーであると考えられた． (キーワード) 悪性リンパ腫 / 臨床試験 / 口腔領域 / リンパ球/単球数比 (徳島大学機関リポジトリ) ● Metadata: 116069 (出版サイトへのリンク) ● Publication site (DOI): 10.5843/jsot.33.35 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390851398293094784 ● Search Scopus @ Elsevier (DOI): 10.5843/jsot.33.35 (徳島大学機関リポジトリ: 116069, DOI: 10.5843/jsot.33.35, CiNii: 1390851398293094784)
10.	Takamitsu Mano, Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Naito Kurio, Kunio Ishikawa and Youji Miyamoto : Histological comparison of three apatitic bone substitutes with different carbonate contents in alveolar bone defects in a beagle mandible with simultaneous implant installation., Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.108, No.4, 1450-1459, 2020. (要約) Since bone apatite is a carbonate apatite containing carbonate in an apatitic structure, carbonate content may be one of the factors governing the osteoconductivity of apatitic bone substitutes. The aim of this study was to evaluate the effects of carbonate content on the osteoconductivity of apatitic bone substitutes using three commercially available bone substitutes for the reconstruction of alveolar bone defects of a beagle mandible with simultaneous dental implant installation. NEOBONE, Bio-Oss, and Cytrans that contain 0.1, 5.5, and 12.0 mass% of carbonate, respectively, were used in this study. The amount of newly formed bone in the upper portion of the alveolar bone defect of the beagle's mandible was 0.7, 6.6, and 39.4% at 4 weeks after surgery and 4.7, 39.5, and 75.2% at 12 weeks after surgery for NEOBONE, Bio-Oss, and Cytrans, respectively. The results indicate that bone-to-implant contact ratio was the largest for Cytrans. Additionally, the continuity of the alveolar ridge was restored in the case of Cytrans, whereas the continuity of the alveolar ridge was not sufficient when using NEOBONE and Bio-Oss. Both Cytrans and Bio-Oss that have a relatively larger carbonate content in their apatitic structure was resorbed with time. We concluded that carbonate content is one of important factors governing the osteoconductivity of apatitic bone substitutes. (徳島大学機関リポジトリ) ● Metadata: 113813 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.b.34492 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31622016 ● Search Scopus @ Elsevier (PMID): 31622016 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.34492 (徳島大学機関リポジトリ: 113813, DOI: 10.1002/jbm.b.34492, PubMed: 31622016)
11.	Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Naito Kurio, Keiko Kudoh, Tsuru Kanji, Ishikawa Kunio and Youji Miyamoto : Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects, Journal of Biomedical Materials Research. Part A, Vol.108, No.3, 709-721, 2020. (要約) Carbonate apatite (CO Ap) granules are known to show good osteoconductivity and replaced to new bone. On the other hand, it is well known that a porous structure allows bone tissue to penetrate its pores, and the optimal pore size for bone ingrowth is dependent on the composition and structure of the scaffold material. Therefore, the aim of this study was to fabricate various porous CO Ap granules through a two-step dissolution-precipitation reaction using CaSO as a precursor and 30-, 50-, 120-, and 205-μm diameter microfibers as porogen and to find the optimal pore size of CO Ap. Porous CO Ap granules were successfully fabricated with pore size 8.2-18.7% smaller than the size of the original fiber porogen. Two weeks after the reconstruction of rabbit calvarial bone defects using porous CO Ap granules, the largest amount of mature bone was seen to be formed inside the pores of CO Ap (120) [porous CO Ap granules made using 120-μm microfiber] followed by CO Ap (50) and CO Ap (30). At 4 and 8 weeks, no statistically significant difference was observed based on the pore size, even though largest amount of mature bone was formed in case of CO Ap (120). It is concluded, therefore, that the optimal pore size of the CO Ap is that of CO Ap (120), which is 85 μm. (徳島大学機関リポジトリ) ● Metadata: 114682 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.a.36850 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31756282 ● Summary page in Scopus @ Elsevier: 2-s2.0-85076129237 (徳島大学機関リポジトリ: 114682, DOI: 10.1002/jbm.a.36850, PubMed: 31756282, Elsevier: Scopus)
12.	Takayuki Nakagawa, Keiko Kudoh, Naoyuki Fukuda, Noriko Tachikawa, Kiyoshi Koyano, Yasuyuki Matsushita, Kunio Ishikawa and Youji Miyamoto : Application of low-crystalline carbonate apatite granules in 2-stage sinus floor augmentation: a prospective clinical trial and histomorphometric evaluation., Journal of Periodontal & Implant Science, Vol.49, No.6, 382-396, 2019. (要約) The purpose of this study was to elucidate the efficacy and safety of carbonate apatite (COAp) granules in 2-stage sinus floor augmentation through the radiographic and histomorphometric assessment of bone biopsy specimens. Two-stage sinus floor augmentation was performed on 13 patients with a total of 17 implants. Radiographic assessment using panoramic radiographs was performed immediately after augmentation and was also performed 2 additional times, at 7±2 months and 18±2 months post-augmentation, respectively. Bone biopsy specimens taken from planned implant placement sites underwent micro-computed tomography, after which histological sections were prepared. Postoperative healing of the sinus floor augmentation was uneventful in all cases. The mean preoperative residual bone height was 3.5±1.3 mm, and this was increased to 13.3±1.7 mm by augmentation with the COAp granules. The mean height of the augmented site had decreased to 10.7±1.9 mm by 7±2 months after augmentation; however, implants with lengths in the range of 6.5 to 11.5 mm could still be placed. The mean height of the augmented site had decreased to 9.6±1.4 mm by 18±2 months post-augmentation. No implant failure or complications were observed. Few inflammatory cells or foreign body giant cells were observed in the bone biopsy specimens. Although there were individual differences in the amount of new bone detected, new bone was observed to be in direct contact with the COAp granules in all cases, without an intermediate layer of fibrous tissue. The amounts of bone and residual COAp were 33.8%±15.1% and 15.3%±11.9%, respectively. In this first demonstration, low-crystalline COAp granules showed excellent biocompatibility, and bone biopsy showed them to be replaced with bone in humans. COAp granules are a useful and safe bone substitute for two-stage sinus floor augmentation. ICTRP Identifier: JPRN-UMIN000019281. (徳島大学機関リポジトリ) ● Metadata: 114105 (出版サイトへのリンク) ● Publication site (DOI): 10.5051/jpis.2019.49.6.382 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31886030 ● Search Scopus @ Elsevier (PMID): 31886030 ● Search Scopus @ Elsevier (DOI): 10.5051/jpis.2019.49.6.382 (徳島大学機関リポジトリ: 114105, DOI: 10.5051/jpis.2019.49.6.382, PubMed: 31886030)
13.	Naoyuki Fukuda, Kunio Ishikawa, Kazuya Akita, Kumiko Kamada, Naito Kurio, Yoshihide Mori and Youji Miyamoto : Effects of acidic calcium phosphate concentration on setting reaction and tissue response to β-tricalcium phosphate granular cement., Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 2019. (要約) Beta-tricalcium phosphate granular cement (β-TCP GC), consisting of β-TCP granules and an acidic calcium phosphate (Ca-P) solution, shows promise in the reconstruction of bone defects as it sets to form interconnected porous structures, that is, β-TCP granules are bridged with dicalcium phosphate dihydrate (DCPD) crystals. In this study, the effects of acidic Ca-P solution concentration (0-600 mmol/L) on the setting reaction and tissue response to β-TCP GC were investigated. The β-TCP GC set upon mixing with its liquid phase, based on the formation of DCPD crystals, which bridged β-TCP granules to one another. Diametral tensile strength of the set β-TCP GC was relatively the same, at ∼0.6 MPa, when the Ca-P concentration was 20-600 mmol/L. Due to the setting ability, reconstruction of the rat's calvarial bone defect using β-TCP GC with 20, 200, and 600 mmol/L Ca-P solution was much easier compared to that with β-TCP granules without setting ability. Four weeks after the reconstruction, the amount of new bone was the same, ∼17% in both β-TCP GC and β-TCP granules groups. Cellular response to β-TCP granules and β-TCP GC using the 20 mmol/L acidic Ca-P solution was almost the same. However, β-TCP GC using the 200 and 600 mmol/L acidic Ca-P solution showed a more severe inflammatory reaction. It is concluded, therefore, that β-TCP GC, using the 20 mmol/L acidic Ca-P solution, is recommended as this concentration allows surgical techniques to be performed easily and provides good mechanical strength, and the similar cellular response to β-TCP granules. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B, 2019. (徳島大学機関リポジトリ) ● Metadata: 116068 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.b.34361 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30884116 ● Search Scopus @ Elsevier (PMID): 30884116 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.34361 (徳島大学機関リポジトリ: 116068, DOI: 10.1002/jbm.b.34361, PubMed: 30884116)
14.	Keiko Kudoh, Naoyuki Fukuda, Shohei Kasugai, Noriko Tachikawa, Kiyoshi Koyano, Yasuyuki Matsushita, Yoichiro Ogino, Kunio Ishikawa and Youji Miyamoto : Maxillary Sinus Floor Augmentation Using Low-Crystalline Carbonate Apatite Granules With Simultaneous Implant Installation: First-in-Human Clinical Trial., Journal of Oral and Maxillofacial Surgery, Vol.77, No.5, 985.e1-985.e11, 2018. (要約) Carbonate apatite (COAp), an inorganic component of human bone, can be fabricated in chemically pure form from calcium carbonate block via a dissolution-precipitation reaction. A first-in-human clinical trial was conducted in which low-crystalline COAp granules were evaluated for safety and efficacy in sinus floor augmentation and simultaneous implant installation. Procedures were performed in 8 patients (9 implants) with 2 granule sizes: small (300 to 600 μm) and medium (600 to 1,000 μm). Panoramic radiographic assessment was performed immediately after augmentation, 7 ± 2 months after augmentation, 6 ± 2 months after prosthetic loading, and 12 ± 2 months after prosthetic loading. Postoperative healing was uniformly uneventful, with no abnormal bleeding, pain, or swelling, and all implants achieved successful osseointegration. The mean residual maxillary molar bone height was 5.2 ± 0.8 mm preoperatively and increased to 14.0 ± 1.9 mm after augmentation. Implants 9.0 to 11.5 mm in length were placed. The post-augmentation height decreased to 12.4 ± 1.3 mm at 7 ± 2 months; after prosthetic loading, it decreased to 11.9 ± 0.8 mm at 6 ± 2 months and 11.7 ± 0.6 mm at 12 ± 2 months. No abnormal bone resorption of the augmented areas was observed, and bone height supporting the implants was maintained. The overall implant survival rate was 100%, with no implant failures or complications during the first year. Low-crystalline COAp granules were useful and safe for sinus floor augmentation and simultaneous implant installation, providing a promising bone substitute for dental implant surgery. (キーワード) Apatites / Dental Implantation, Endosseous / Dental Implants / Dental Restoration Failure / Follow-Up Studies / Humans / Maxillary Sinus / Sinus Floor Augmentation / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.joms.2018.11.026 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30597134 ● Summary page in Scopus @ Elsevier: 2-s2.0-85061215753 (DOI: 10.1016/j.joms.2018.11.026, PubMed: 30597134, Elsevier: Scopus)
15.	Naoyuki Fukuda, Masayuki Kanazawa, Kanji Tsuru, Akira Tsuchiya, (名) Sunarso, Riki Toita, Yoshihide Mori, Yasuharu Nakashima and Kunio Ishikawa : Synergistic effect of surface phosphorylation and micro-roughness on enhanced osseointegration ability of poly(ether ether ketone) in the rabbit tibia., Scientific Reports, Vol.8, No.1, 16887, 2018. (要約) This study was aimed to investigate the osseointegration ability of poly(ether ether ketone) (PEEK) implants with modified surface roughness and/or surface chemistry. The roughened surface was prepared by a sandblast method, and the phosphate groups on the substrates were modified by a two-step chemical reaction. The in vitro osteogenic activity of rat mesenchymal stem cells (MSCs) on the developed substrates was assessed by measuring cell proliferation, alkaline phosphatase activity, osteocalcin expression, and bone-like nodule formation. Surface roughening alone did not improve MSC responses. However, phosphorylation of smooth substrates increased cell responses, which were further elevated in combination with surface roughening. Moreover, in a rabbit tibia implantation model, this combined surface modification significantly enhanced the bone-to-implant contact ratio and corresponding bone-to-implant bonding strength at 4 and 8 weeks post-implantation, whereas modification of surface roughness or surface chemistry alone did not. This study demonstrates that combination of surface roughness and chemical modification on PEEK significantly promotes cell responses and osseointegration ability in a synergistic manner both in vitro and in vivo. Therefore, this is a simple and promising technique for improving the poor osseointegration ability of PEEK-based orthopedic/dental implants. (徳島大学機関リポジトリ) ● Metadata: 114066 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-018-35313-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30442906 ● Search Scopus @ Elsevier (PMID): 30442906 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-018-35313-7 (徳島大学機関リポジトリ: 114066, DOI: 10.1038/s41598-018-35313-7, PubMed: 30442906)
16.	Naoyuki Fukuda, Akira Tsuchiya, (名) Sunarso, Riki Toita, Kanji Tsuru, Yoshihide Mori and Kunio Ishikawa : Surface plasma treatment and phosphorylation enhance the biological performance of poly(ether ether ketone)., Colloids and Surfaces B:Biointerfaces, Vol.173, 36-42, 2018. (要約) Poly(ether ether ketone) (PEEK) has emerged as an alternative endosseous material to metal implants mainly because of its lack of allergic sensitivity and radiolucency, while maintaining similar mechanical properties with bone. However, a disadvantage of PEEK is its weak osseointegration ability compared with metal implants. To overcome this, we prepared a phosphate group-modified PEEK by plasma treatment and subsequent phosphorylation reaction. Plasma treatment and phosphate modification of PEEK changed its hydrophobic surface to a hydrophilic surface while maintaining the original surface topography and roughness. Phosphate modification increased the bioactivity of rat bone marrow stromal cells (BMSCs), including proliferation, alkaline phosphatase activity, and bone-like nodule formation; however, this effect was negligible in plasma-treated PEEK. In addition, phosphate modification attenuated the phenotypic polarization of lipopolysaccharide-primed RAW264.7 macrophages to an inflammatory phenotype, based on the finding that macrophages on phosphate-modified PEEK produced decreased levels of the inflammatory cytokine and increased levels of the anti-inflammatory cytokine. Finally, in an animal study, phosphate-modified PEEK exhibited a doubled pullout force from the femur bone cavity compared with bare PEEK. Thus, we conclude that phosphate modification can significantly improves the implant-bone bonding strength of PEEK by enhancing BMSCs activity and reducing excessive inflammation. (キーワード) Alkaline Phosphatase / Animals / Benzophenones / Biocompatible Materials / Bone Marrow Cells / Bone-Implant Interface / Calcification, Physiologic / Cell Differentiation / Cell Proliferation / Femur / Hydrophobic and Hydrophilic Interactions / Lipopolysaccharides / Macrophage Activation / Male / Mice / Osteoblasts / Osteogenesis / Phosphorylation / Plasma Gases / Polymers / Primary Cell Culture / RAW 264.7 Cells / Rats / Rats, Wistar / Stromal Cells / Surface Properties (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.colsurfb.2018.09.032 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30266018 ● Search Scopus @ Elsevier (PMID): 30266018 ● Search Scopus @ Elsevier (DOI): 10.1016/j.colsurfb.2018.09.032 (DOI: 10.1016/j.colsurfb.2018.09.032, PubMed: 30266018)
17.	Kenji Fujisawa, Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Takaharu Kudoh, Go Ohe, Takamitsu Mano, Kanji Tsuru, Kunio Ishikawa and Youji Miyamoto : Compositional and histological comparison of carbonate apatite fabricated by dissolutionprecipitation reaction and Bio-Oss®., Journal of Materials Science. Materials in Medicine, Vol.29, No.8, 121, 2018. (要約) Carbonate apatite (COAp) is an inorganic component of bone. This study aimed to compare the composition and tissue response to of COAp (COAp-DP) fabricated by the dissolution-precipitation reaction using calcite as a precursor and Bio-Oss®, which is widely used in orthopedic and dental fields as a synthetic bone substitute. X-ray diffraction and Fourier transform infrared results showed that COAp-DP and Bio-Oss® were both B-type carbonate apatite with low crystallinity. The average sizes of COAp-DP and Bio-Oss® granules were 450 ± 58 and 667 ± 168μ m, respectively, and their carbonate contents were 12.1 ± 0.6 and 5.6 ± 0.1 wt%, respectively. COAp-DP had a larger amount of CO than Bio-Oss® but higher crystallinity than Bio-Oss®. When a bone defect made at the femur of rabbits was reconstructed with COAp-DP and Bio-Oss®, COAp-DP granules were partially replaced with bone, whereas Bio-Oss® remained at 8 weeks after implantation. COAp-DP granules elicited a significantly larger amount of new bone formation at the cortical bone portion than Bio-Oss® at 4 weeks after the implantation. The results obtained in the present study demonstrated that COAp-DP and Bio-Oss® showed different behavior even though they were both classified as COAp. The CO content in COAp played a more important role than the crystallinity of COAp for replacement to bone and high osteoconductivity. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10856-018-6129-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30032409 ● Summary page in Scopus @ Elsevier: 2-s2.0-85050411033 (DOI: 10.1007/s10856-018-6129-2, PubMed: 30032409, Elsevier: Scopus)
18.	(名) Sunarso, Akira Tsuchiya, Naoyuki Fukuda, Riki Toita, Kanji Tsuru and Kunio Ishikawa : Effect of micro-roughening of poly(ether ether ketone) on bone marrow derived stem cell and macrophage responses, and osseointegration., Journal of Biomaterials Science. Polymer Edition, Vol.29, No.12, 1375-1388, 2018. (要約) Poly(ether ether ketone) (PEEK) has emerged as a candidate to replace metal implants because of its satisfactory mechanical properties, radiolucency, and lack of metal allergy. However, PEEK lacks osseointegration ability limiting its clinical applications. To overcome this problem, we prepared PEEK with a micro-rough surface using the sandblast method to modulate its osseointegration property; the sandblast method is simple, cost-effective, and is already applied to clinical metal implants. The surface roughness of the sandblasted PEEK was about 2.3 μm, whereas that of mirror-polished PEEK was 0.06 μm. Rat bone marrow-derived mesenchymal stem cells (RMSCs) showed higher proliferation, osteocalcin (OC) expression and bone-like nodule formation on micro-roughened PEEK compared with those cultured on mirror-polished PEEK, suggesting that micro-roughening facilitated RMSCs proliferation and differentiation. The micro-roughened surface slightly mitigated secretion of inflammatory C-C motif chemokine 2 (CCL-2) from lipopolysaccharide (LPS)-stimulated macrophages, but not of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6). Finally, to compare osseointegration, specimens were implanted in rat femur bone marrow cavities, and then the pull-out force was measured. The pull-out force of micro-roughened PEEK was about four times higher than that of the mirror-polished PEEK. These results showed that micro-roughening of PEEK using the sandblast method was able to improve osseointegration, partly through elevating proliferation and differentiation of RMSCs. (出版サイトへのリンク) ● Publication site (DOI): 10.1080/09205063.2018.1461448 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29661104 ● Search Scopus @ Elsevier (PMID): 29661104 ● Search Scopus @ Elsevier (DOI): 10.1080/09205063.2018.1461448 (DOI: 10.1080/09205063.2018.1461448, PubMed: 29661104)
19.	Masayuki Kanazawa, Kanji Tsuru, Naoyuki Fukuda, Yuta Sakemi, Yasuharu Nakashima and Kunio Ishikawa : Evaluation of carbonate apatite blocks fabricated from dicalcium phosphate dihydrate blocks for reconstruction of rabbit femoral and tibial defects., Journal of Materials Science. Materials in Medicine, Vol.28, No.6, 85, 2017. (要約) This study aimed to evaluate in vivo behavior of a carbonate apatite (COAp) block fabricated by compositional transformation via a dissolution-precipitation reaction using a calcium hydrogen phosphate dihydrate [DCPD: CaHPO·2HO] block as a precursor. These blocks were used to reconstruct defects in the femur and tibia of rabbits, using sintered dense hydroxyapatite (HAp) blocks as the control. Both the COAp and HAp blocks showed excellent tissue response and good osteoconductivity. HAp block maintained its structure even after 24 weeks of implantation, so no bone replacement of the implant was observed throughout the post-implantation period in either femoral or tibial bone defects. In contrast, COAp was resorbed with increasing time after implantation and replaced with new bone. The COAp block was resorbed approximately twice as fast at the metaphysis of the proximal tibia than at the epiphysis of the distal femur. The COAp block was resorbed at an approximately linear change over time, with complete resorption was estimated by extrapolation of data at approximately 1-1.5 years. Hence, the COAp block fabricated in this study has potential value as an ideal artificial bone substitute because of its resorption and subsequent replacement by bone. (キーワード) Animals / Apatites / Bone Substitutes / Calcium Phosphates / Durapatite / Epiphyses / Femur / Prostheses and Implants / Rabbits / Tibia (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10856-017-5896-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28456893 ● Search Scopus @ Elsevier (PMID): 28456893 ● Search Scopus @ Elsevier (DOI): 10.1007/s10856-017-5896-5 (DOI: 10.1007/s10856-017-5896-5, PubMed: 28456893)
20.	Naoyuki Fukuda, Kanji Tsuru, Yoshihide Mori and Kunio Ishikawa : Fabrication of self-setting β-tricalcium phosphate granular cement., Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.106, No.2, 800-807, 2017. (要約) Bone defect reconstruction would be greatly improved if β-tricalcium phosphate (β-TCP) granules had the ability to self-set without sacrificing their osteoconductivity potential. This study aimed to identify a method to permit β-TCP self-setting whilst maintaining good osteoconductivity. When mixed with acidic calcium phosphate solution, β-TCP granules were found to readily set, forming a fully interconnected porous structure. On mixing, dicalcium phosphate dihydrate crystals formed on the surface of β-TCP granules, bridging the granules and resulting in the setting reaction. The setting time of the β-TCP granular cement (β-TCP GC) was approximately 1 min and its mechanical strength, in terms of diametral tensile strength, was approximately 0.8 MPa. The β-TCP GC and β-TCP granules both showed the same level of osteoconductivity within rat calvaria bone defects. At 2 and 4 weeks post-implantation, new bone formation was comparable between the two β-TCP based bone substitutes. We conclude that β-TCP GC has excellent potential for use as a cement in bone defect reconstruction. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 800-807, 2018. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.b.33891 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28370963 ● Search Scopus @ Elsevier (PMID): 28370963 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.33891 (DOI: 10.1002/jbm.b.33891, PubMed: 28370963)
21.	Naoyuki Fukuda, Kanji Tsuru, Yoshihide Mori and Kunio Ishikawa : Effect of citric acid on setting reaction and tissue response to β-TCP granular cement., Biomedical Materials, Vol.12, No.1, 015027, 2017. (要約) We recently reported that when an acidic calcium phosphate solution is mixed with β-tricalcium phosphate (β-TCP) granules, the resulting dicalcium phosphate dihydrate (DCPD) crystals form bridges between the β-TCP granules, creating a set interconnected porous structure in approximately 1 min. Although this self-setting β-TCP granular cement (β-TCPGC) is useful for clinical applications, the short setting time is a key drawback for handling. In this study, the setting time of β-TCPGC was adjusted with the addition of citric acid, which is a known inhibiter of DCPD crystal growth. As the concentration of citric acid in the acidic calcium phosphate solution increased, the amount of DCPD formation in the set β-TCPGC decreased, and the crystal morphology of DCPD became elongated. β-TCPGC prepared with various citric acid concentrations were used as grafting material in rat calvarial bone defects to evaluate bone regeneration in vivo. Four weeks after implantation, no inflammatory reaction and approximately 20% new bone formation were observed, regardless of the presence or absence of citric acid in the liquid phase of β-TCPGC. We concluded, therefore, that citric acid might be a useful retarder of β-TCPGC setting times. (キーワード) Animals / Biocompatible Materials / Biomechanical Phenomena / Bone Cements / Bone Regeneration / Calcium Phosphates / Citric Acid / 結晶化 (crystallization) / Hydrogen-Ion Concentration / Male / Materials Testing / Porosity / Rats / Rats, Wistar / Skull / X-Ray Microtomography (出版サイトへのリンク) ● Publication site (DOI): 10.1088/1748-605X/aa5aea (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28233758 ● Summary page in Scopus @ Elsevier: 2-s2.0-85015987932 (DOI: 10.1088/1748-605X/aa5aea, PubMed: 28233758, Elsevier: Scopus)
22.	西山祐生, 福田直志, 助臺美帆, 村木祐孝 : 頰部蜂窩織炎の治療中に脳梗塞を発症した1例, 日本口腔診断学会雑誌, Vol.28, No.2, 134-140, 2015年. (要約) We report the case of a patient who underwent treatment for phlegmon of the cheek and developed a cerebral infarction. We also review some relevant literature. An 88-year-old woman noticed swelling and experienced pain in her left mandible. The patient visited the cardiology department of a nearby general hospital. After examination, she was diagnosed with exacerbated heart failure and was admitted to the hospital. Although anti-inflammatory treatment was administered, no improvement was observed in her symptoms, so she was referred to our hospital for a more detailed examination and further treatment. The patient was diagnosed with phlegmon of the left cheek and was admitted to our hospital. She was administered antibacterial drugs via an intravenous drip. On day 3 of hospitalization, she underwent extra-oral incision and drainage under general anesthesia. Her postoperative course was satisfactory, however, on day 13, severe right hemiplegia and aphasia were observed, and her consciousness level declined. She was diagnosed with cardiogenic cerebral embolism and was transferred to the neurosurgery department. She received antithrombotic therapy with warfarin. Poor control of perioperative anticoagulation ability was considered to be one cause of the cerebral infarction. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680712885248 (CiNii: 1390282680712885248)
23.	K Inoue, H Nakano, T Sumida, T Yamada, N Otawa, Naoyuki Fukuda, Y Nakajima, W Kumamaru, K Mishima, M Kouchi, I Takahashi and Y Mori : A novel measurement method for the morphology of the mandibular ramus using homologous modelling., Dento Maxillo Facial Radiology, Vol.44, No.8, 2015. (要約) In conclusion, we successfully created a homologous model of the mandibular ramus and demonstrated the effectiveness of this model in the 3D comparison of the ramus morphology between the contralateral and deviated sides in asymmetric mandibles. (キーワード) Adolescent / Adult / Anatomic Landmarks / Cephalometry / Computer-Aided Design / Facial Asymmetry / Female / Humans / Image Processing, Computer-Assisted / Imaging, Three-Dimensional / Mandible / Mandibular Condyle / Models, Anatomic / Principal Component Analysis / Prognathism / Retrospective Studies / Tomography, X-Ray Computed / Young Adult (出版サイトへのリンク) ● Publication site (DOI): 10.1259/dmfr.20150062 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26143939 ● Search Scopus @ Elsevier (PMID): 26143939 ● Search Scopus @ Elsevier (DOI): 10.1259/dmfr.20150062 (DOI: 10.1259/dmfr.20150062, PubMed: 26143939)

学術論文(紀要・その他):

1.	宮本洋二, 福田直志, 工藤景子 : 口腔領域における骨補填材としての炭酸アパタイトの現状と今後の展開, 日本口腔インプラント学会誌, Vol.35, No.4, 268-275, 2022年. (徳島大学機関リポジトリ) ● Metadata: 117953 (徳島大学機関リポジトリ: 117953)

総説・解説:

1.	宮本洋二, 福田直志, 秋田和也, 工藤景子, 栗尾奈愛 : 骨補填材としての炭酸アパタイトの現状と今後の展開, 日本顎顔面インプラント学会誌, Vol.20, No.2, 88-95, 2021年8月. (要約) A main inorganic component of human bone is not hydroxyapatite but carbonate apatite (CQ3Ap). Hydroxyapatite is not resorbed in the body but C03Ap can be resorbed and replaced with bone. We have succeeded in fabricating low crystalline CQ3Ap without sintering by dissolution-precipitation reaction using calcium hydroxide as a precursor. C03Ap showed excellent biocompatibility and faster bone formation compared to other bone substitutes (anorganic bovine bone and hydroxyapatite) in rabbit femur and dog mandible. Clinical study on effectiveness and safety of C03Ap granules in sinus floor augmentation was successfully concluded in 2016. CQ3Ap granules were approved by Japanese government in 2017, and marketed in 2018 as Cytrans® Granules. This comprehensive review explains the clinical cases of sinus lift and alveolar ridge augmentation of Cytrans® and its recommended clinical usage. Furthermore, we have succeeded in developing porous C03Ap and showed it was useful for reconstruction of mandibular bone defect in rabbit model and also aim to use it as a scaffold for bone regenerative medicine. (キーワード) apatite / bone substitute / bone regenerative medicine / carbonate apatite / アパタイト / 骨補填材 / 骨再生医療 / 炭酸アパタイト (徳島大学機関リポジトリ) ● Metadata: 116329 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050010776440040320 (徳島大学機関リポジトリ: 116329, CiNii: 1050010776440040320)
2.	宮本洋二, 山中克之, 福田直志, 秋田和也 : 再生療法の最前線 Ⅳ．サイトランスグラニュールを活用するためのポイント(Q&A), 日本歯科評論, Vol.79, No.9, 58-63, 2019年8月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1521417755960165504 (CiNii: 1521417755960165504)
3.	宮本洋二, 山中克之, 福田直志, 秋田和也 : 再生療法の最前線 Ⅲ．サイトランスグラニュールを効果的に使用するために知っておきたい知識(概説), 日本歯科評論, Vol.79, No.9, 54-57, 2019年8月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1522262179862336768 (CiNii: 1522262179862336768)

国際会議:

1.	Naoyuki Fukuda, Takamitsu Mano, Kazuya Akita, 鎌田久美子, Takayuki Nakagawa and Youji Miyamoto : Effects Of Acidic Calcium Phosphate Concentration On Setting Reaction To ß-Tricalcium Phosphate Granular Cement, 24th Congress of the European Association for Cranio Maxillo Facial Surgery, Sep. 2018.
2.	Takamitsu Mano, Naoyuki Fukuda, Kazuya Akita, Kumiko Kamada, Naito Kurio and Youji Miyamoto : Comparative Study On Tissue Response To Low Crystalline Carbonate Apatite, NEOBONE® And Bio-Oss® In A Dog Model, 24th Congress of the European Association for Cranio Maxillo Facial Surgery, Sep. 2018.

国内講演発表:

1.	福田直志, 秋田和也, 髙丸菜都美, 工藤景子, 宮本洋二 : 顎骨嚢胞摘出後に炭酸アパタイト骨補填材を充填した2例, 第27回日本顎顔面インプラント学会総会・学術大会, 2023年12月.
2.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : 操作・保持性を向上した炭酸アパタイト・コラーゲンスポンジの開発と骨再建への応用, 第27回日本顎顔面インプラント学会総会・学術大会, 2023年12月.
3.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 工藤隆治, 栗尾奈愛, 宮本洋二 : 炭酸アパタイト製骨補填材の炭酸基量を変えることによる吸収性と骨新生のコントロール, 第68回日本口腔外科学会総会・学術大会, 2023年11月.
4.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : インプラント治療を前提とした炭酸アパタイト骨補填材を用いた骨増生法の提案, 第43回日本口腔インプラント学会中国・四国支部学術大会, 2023年10月.
5.	福田直志, 秋田和也, 髙丸菜都美, 工藤景子, 宮本洋二 : 顎骨嚢胞摘出後の骨欠損に使用した炭酸アパタイト骨補填材の長期経過, 第43回日本口腔インプラント学会近畿・北陸支部学術大会, 2023年10月.
6.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイト骨補填材の歯槽骨造成術への応用, 第43回日本口腔インプラント学会近畿・北陸支部学術大会, 2023年10月.
7.	野上幸裕, 福田直志, 秋田和也, 浦田豊彰, 髙丸菜都美, 工藤隆治, 高橋章, 宮本洋二 : 下顎のエナメル上皮腫と歯原性角化嚢胞のCTによる画像診断学的検討, 第70回NPO法人日本口腔科学会中国・四国地方部会, 2023年10月.
8.	福田直志, 秋田和也, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイトハニカムブロックによる新規骨再建・骨造成法の開発, 第53回公益社団法人日本口腔インプラント学会学術大会, 2023年9月.
9.	髙丸菜都美, 福田直志, 栗尾奈愛, 宮本洋二 : 顎矯正手術患者の術後悪心嘔吐に対するオンダンセトロンの有用性の検討, 第33回特定非営利活動法人日本顎変形症学会総会・学術大会, 2023年6月.
10.	秋田和也, 髙丸菜都美, 福田直志, 浦田豊彰, 宮本洋二 : 術後再発をきたしたセメント芽細胞腫の1例, 第77回NPO法人日本口腔科学会学術集会, 2023年5月.
11.	浦田豊彰, 髙丸菜都美, 福田直志, 秋田和也, 宮本洋二 : 当科におけるメトトレキサート関連リンパ増殖性疾患(MTX-LPD)の臨床的検討, 第51回口腔外科学会中国四国支部学術集会(WEB開催), 2022年12月.
12.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸含有量が多孔質炭酸アパタイト顆粒の骨置換性に及ぼす影響, 第26回日本顎顔面インプラント学会総会, 2022年11月.
13.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 石川邦夫, 宮本洋二 : 炭酸含有量を調整した多孔質炭酸アパタイト顆粒による骨形成と吸収能の制御, 第44回日本バイオマテリアル学会大会, 2022年11月.
14.	福田直志, 秋田和也, 鎌田久美子, 髙丸菜都美, 工藤景子, 栗尾奈愛, 宮本洋二 : 炭酸アパタイト製骨補填材を用いた上顎洞底挙上術後の長期予後について, 公益社団法人日本口腔インプラント学会第42回中国・四国支部学術大会, 2022年11月.
15.	秋田和也, 福田直志, 髙丸菜都美, 工藤隆治, 工藤景子, 栗尾奈愛, 宮本洋二 : 炭酸基量の異なる多孔質炭酸アパタイト顆粒の開発と骨再建, 第67回日本口腔外科学会総会・学術集会, 2022年11月.
16.	福田直志, 髙丸菜都美, 秋田和也, 工藤景子, 常松貴明, 石丸直澄, 宮本洋二 : 超選択的動脈塞栓術を併用して治療した上顎中心性巨細胞肉芽腫の1例, 第67回日本口腔外科学会総会・学術大会, 2022年11月.
17.	髙丸菜都美, 福田直志, 秋田和也, 工藤景子, 宮本洋二 : 3次元網状連通気孔を有する炭酸アパタイトブロックの開発, 第67回日本口腔外科学会総会・学術大会, 2022年11月.
18.	工藤景子, 福田直志, 秋田和也, 工藤隆治, 髙丸菜都美, 栗尾奈愛, 宮本洋二 : ハニカム構造を有する炭酸アパタイト多孔体によるウサギ下顎骨再建への応用, 第67回日本口腔外科学会総会・学術大会, 2022年11月.
19.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイト顆粒と豚コラーゲンの複合化による新規骨補填材の開発と骨再生, 第52回公益社団法人日本口腔インプラント学会学術大会, 2022年9月.
20.	福田直志, 秋田和也, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイトハニカムブロックによる新規骨造成法の開発, 第52回公益社団法人日本口腔インプラント学会学術大会, 2022年9月.
21.	福田直志, 髙丸菜都美, 秋田和也, 工藤景子, 宮本洋二 : 炭酸アパタイトハニカムブロックの開発と外側性骨造成への応用, 第76回NPO法人日本口腔科学会学術集会, 2022年4月.
22.	秋田和也, 福田直志, 髙丸菜都美, 工藤隆治, 工藤景子, 栗尾奈愛, 高橋章, 宮本洋二 : 炭酸アパタイト顆粒(サイトランスグラニュール)の歯槽骨造成術およびソケットプリザベーションへの応用, 第50回(公社)日本口腔外科学会中国四国支部学術集会, 2022年1月.
23.	鎌田久美子, 栗尾奈愛, 上杉篤史, 横田美保, 秋田和也, 福田直志, 山村佳子, 工藤隆治, 髙丸菜都美, 工藤景子, 高橋章, 宮本洋二 : 歯性感染症により発症した側頭部ガス壊疽の1例, 第50回(公社)日本口腔外科学会中国四国支部学術集会, 2022年1月.
24.	秋田和也, 福田直志, 椋本修平, 髙丸菜都美, 工藤景子, 都留寛治, 石川邦夫, 宮本洋二 : 炭酸基含有量の異なる多孔質炭酸アパタイト顆粒の開発, 第51回公益財団法人日本口腔インプラント学会学術大会, 2021年12月.
25.	福田直志, 秋田和也, 椋本修平, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイト製骨補填材による広範囲骨欠損の即時再建, 第51回公益財団法人日本口腔インプラント学会学術大会, 2021年12月.
26.	福田直志, 秋田和也, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイトハニカムブロックを用いたベニアグラフトの実験的検討, 第25回公益社団法人日本顎顔面インプラント学会総会・学術大会, 2021年12月.
27.	秋田和也, 福田直志, 鎌田久美子, 上杉篤史, 山村佳子, 工藤隆治, 髙丸菜都美, 工藤景子, 栗尾奈愛, 高橋章, 宮本洋二 : 炭酸アパタイト顆粒(サイトランスグラニュール)を用いて歯槽骨造成を行った2例, 第68 回NPO 法人日本口腔科学会中国・四国地方部会, 2021年11月.
28.	福田直志, 髙丸菜都美, 秋田和也, 椋本修平, 工藤景子, 宮本洋二 : 嚢胞摘出後の骨欠損を炭酸アパタイト製骨補填材で即時再建した1例, 第66回日本口腔外科学会総会・学術大会, 2021年11月.
29.	福田直志, 髙丸菜都美, 秋田和也, 椋本修平, 工藤景子, 宮本洋二 : 嚢胞摘出後の骨欠損を炭酸アパタイト製骨補填材で即時再建した1例, 第43回日本バイオマテリアル学会, 2021年11月.
30.	工藤景子, 福田直志, 秋田和也, 工藤隆治, 椋本修平, 髙丸菜都美, 栗尾奈愛, 鎌田久美子, 宮本洋二 : 炭酸アパタイト顆粒と魚うろこコラーゲンの複合化による新規骨補填材の開発, 第66回公益社団法人日本口腔外科学会総会・学術大会, 2021年11月.
31.	秋田和也, 福田直志, 鎌田久美子, 大江剛, 眞野隆充, 石川邦夫, 都留寛治, 宮本洋二 : マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の開発とウサギ頭蓋骨における組織学的評価, 第75回日本口腔科学会学術集会, 2021年5月.
32.	椋本修平, 秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイト顆粒(サイトランスグラニュール)の嚢胞摘出術への応用, 第49回(公社)日本口腔外科学会中国四国支部学術大会, 2021年2月.
33.	鎌田久美子, 栗尾奈愛, 福田直志, 横田美保, 秋田和也, 上杉篤史, 山村佳子, 工藤隆治, 高橋章, 宮本洋二 : 口腔癌術後に多発肺結節を認めた敗血症性肺塞栓症の一例, 第49回(公社)日本口腔外科学会中国四国支部学術集会, 2021年2月.
34.	秋田和也, 眞野隆充, 福田直志, 宮本洋二 : 炭酸アパタイトと豚コラーゲンの複合化による新規骨補填材の開発と骨再建への応用, 第24回日本顎顔面インプラント学会学術大会, 2020年12月.
35.	髙丸菜都美, 福田直志, 鎌田久美子, 秋田和也, 大江剛, 栗尾奈愛, 宮本洋二 : 早期口腔扁平上皮癌におけるPD-L1とZEB-1の発現と予後との関連について, 第65回日本口腔外科学会総会・学術大会, 2020年11月.
36.	福田直志, 工藤景子, 秋田和也, 工藤隆治, 髙丸菜都美, 大江剛, 栗尾奈愛, 宮本洋二 : 一方向連通気孔を有する炭酸アパタイトハニカムブロックの開発と顎骨再建への応用, 第65回日本口腔外科学会総会・学術大会, 2020年11月.
37.	福田直志, 秋田和也, 椋本修平, 髙丸菜都美, 工藤景子, 宮本洋二 : 新規骨補填材としてのβ型リン酸三カルシウム顆粒セメントの開発と垂直的骨造成への応用, 第50回公益社団法人日本口腔インプラント学会記念学術大会, 2020年9月.
38.	山村佳子, 眞野隆充, 栗尾奈愛, 工藤隆治, 工藤景子, 福田直志, 宮本洋二 : ピロカルピン塩酸塩を用いた口腔リンス法の有用性と安全性の検討, 第17回日本口腔ケア学会総会・学術大会, 2020年9月.
39.	秋田和也, 福田直志, 工藤景子, 眞野隆充, 宮本洋二 : マイクロファイバーをポロジェンとして用いた炭酸アパタイト多孔体の開発と骨再生医療への応用, 徳島県歯科医学大会, 2020年2月.
40.	工藤景子, 秋田和也, 福田直志, 工藤隆治, 栗尾奈愛, 大江剛, 眞野隆充, 宮本洋二 : 新規骨補填材としての炭酸アパタイトの開発と骨再生医療への応用, 徳島県歯科医学大会, 2020年2月.
41.	山村佳子, 大江剛, 工藤保誠, 栗尾奈愛, 鎌田久美子, 福田直志, 工藤景子, 眞野隆充, 石丸直澄, 宮本洋二 : 口腔扁平苔癬からの癌化が疑われた口腔扁平上皮癌の4例, 第38回日本口腔腫瘍学会総会・学術大会, 2020年1月.
42.	福田直志, 工藤景子, 秋田和也, 工藤隆治, 大江剛, 眞野隆充, 宮本洋二 : 一方向連通気孔を有する炭酸アパタイトハニカムブロックの創製と新規GBR法の開発, 第23回日本顎顔面インプラント学会総会・学術大会, 2019年11月.
43.	工藤景子, 秋田和也, 工藤隆治, 福田直志, 眞野隆充, 大江剛, 林幸壱朗, 石川邦夫, 宮本洋二 : 炭酸アパタイト顆粒と魚うろこコラーゲンの複合化による新規骨補填材の創製, 第41回日本バイオマテリアル学会大会, 2019年11月.
44.	福田直志, 工藤景子, 秋田和也, 工藤隆治, 大江剛, 眞野隆充, 林幸壱朗, 石川邦夫, 宮本洋二 : 一方向連通気孔を有する炭酸アパタイトハニカムブロックの創製と下顎骨再建への応用, 第41回日本バイオマテリアル学会大会, 2019年11月.
45.	福田直志, 眞野隆充, 秋田和也, 鎌田久美子, 中島世市郎, 工藤景子, 工藤隆治, 大江剛, 宮本洋二 : 炭酸アパタイト顆粒を用いた上顎洞底拳上術症例の検討, 日本口腔インプラント学会第39回中国・四国支部学術大会, 2019年11月.
46.	秋田和也, 福田直志, 鎌田久美子, 山村佳子, 工藤景子, 工藤隆治, 栗尾奈愛, 大江剛, 眞野隆充, 宮本洋二 : ナイロンファイバーをポロゲンとして用いた炭酸アパタイト多孔体の開発と骨再建, 第64回日本口腔外科学会総会・学術大会, 2019年10月.
47.	鎌田久美子, 栗尾奈愛, 大江剛, 工藤景子, 山村佳子, 福田直志, 眞野隆充, 工藤保誠, 石丸直澄, 宮本洋二 : 上顎歯肉に発生したMicorocystic adnexal carcinoma(MAC)の1例, 第64回日本口腔外科学会総会・学術大会, 2019年10月.
48.	工藤景子, 福田直志, 秋田和也, 工藤隆治, 大江剛, 栗尾奈愛, 山村佳子, 鎌田久美子, 眞野隆充, 宮本洋二 : ハニカム構造を有する炭酸アパタイト多孔体の開発と下顎骨再建への応用, 第64回日本口腔外科学会総会・学術大会, 2019年10月.
49.	工藤隆治, 工藤景子, 鎌田久美子, 福田直志, 山村佳子, 栗尾奈愛, 眞野隆充, 宮本洋二 : Radiomicsを用いた舌癌の頸部リンパ節転移の予測, 第67回日本口腔科学会中国・四国地方部会, 2019年10月.
50.	鎌田久美子, 栗尾奈愛, 工藤景子, 山村佳子, 福田直志, 中川貴之, 大江剛, 眞野隆充, 宮本洋二 : 開口障害を主訴に来院した破傷風の1症例, 第48回(公社)日本口腔外科学会中国四国支部学術集会, 2019年5月.
51.	秋田和也, 福田直志, 鎌田久美子, 工藤隆治, 眞野隆充, 宮本洋二 : マイクロファイバーを用いた多孔質炭酸アパタオトの創製と骨再建, 第73回日本口腔科学会学術集会, 2019年4月.
52.	福田直志, 宮本洋二 : 生体不活性プラスチックに骨伝導性を付与できるか?, 第22回日本顎顔面インプラント学会総会・学術大会, 2018年12月.
53.	工藤景子, 工藤隆治, 福田直志, 秋田和也, 眞野隆充, 大江剛, 中川貴之, 鎌田久美子, 宮本洋二 : 魚うろこコラーゲンと炭酸アパタイト顆粒の複合化による新規骨再建材料の開発, 第22回日本顎顔面インプラント学会総会・学術大会, 2018年12月.
54.	榊原健人, 中川貴之, 福田直志, 栗尾奈愛, 玉谷哲也, 眞野隆充, 大塚邦紘, 工藤保誠, 石丸直澄, 宮本洋二 : 下顎骨に発生した腺性歯原性嚢胞の1例, 第66回日本口腔科学会中国・四国地方部会, 2018年11月.
55.	工藤隆治, 工藤景子, 福田直志, 秋田和也, 眞野隆充, 大江剛, 中川貴之, 宮本洋二 : 炭酸アパタイト顆粒と魚うろこコラーゲンの複合化による新規骨再建材料の開発, 日本口腔インプラント学会第38回中国・四国支部学術大会, 2018年11月.
56.	福田直志, 秋田和也, 眞野隆充, 宮本洋二 : リン酸カルシウム溶液濃度が自己硬化型β-TCP顆粒セメントに及ぼす影響, 第63回日本口腔外科学会総会・学術大会, 2018年11月.
57.	秋田和也, 福田直志, 鎌田久美子, 大江剛, 眞野隆充, 都留寛治, 石川邦夫, 宮本洋二 : マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の開発と骨再建への応用, 第48回日本口腔インプラント学会学術大会, 2018年9月.
58.	鎌田久美子, 栗尾奈愛, 工藤景子, 中川貴之, 大江剛, 秋田和也, 福田直志, 髙丸菜都美, 玉谷哲也, 眞野隆充, 宮本洋二 : 炭酸アパタイト顆粒(サイトランス○REAグラニュール)の上顎洞底挙上術への応用 -インプラント体同時埋入症例-, 第47回(公社)日本口腔外科学会中国四国支部学術集会, 2018年6月.
59.	秋田和也, 福田直志, 大江剛, 藤澤健司, 眞野隆充, 宮本洋二 : ナイロンファイバーを用いた多孔質炭酸アパタイトの開発, 第72回日本口腔科学会学術集会, 2018年5月.
60.	鎌田久美子, 藤澤健司, 工藤景子, 中川貴之, 大江剛, 秋田和也, 福田直志, 髙丸菜都美, 玉谷哲也, 眞野隆充, 宮本洋二 : 低結晶性炭酸アパタイト顆粒の上顎洞底挙上術への応用徳島大学病院におけるインプラント体同時埋入法の治験症例について, 日本顎顔面インプラント学会総会・学術大会, 2017年12月.
61.	秋田和也, 藤澤健司, 福田直志, 大江剛, 髙丸菜都美, 都留寛治, 石川邦夫, 宮本洋二 : 低結晶性炭酸アパタイト顆粒の顎骨再建への応用 –イヌ顎骨に埋植したインプラント体周囲における組織学的検討-, 日本口腔インプラント学会第37回中国・四国支部学術大会, 2017年11月.
62.	福田直志, 秋田和也, 鎌田久美子, 髙丸菜都美, 中川貴之, 大江剛, 藤澤健司, 宮本洋二 : 硬化遅延材としてのクエン酸が自己硬化型β-TCP顆粒セメントに及ぼす影響, 日本口腔インプラント学会第37回中国・四国支部学術大会, 2017年11月.
63.	秋田和也, 福田直志, 大江剛, 藤澤健司, 宮本洋二 : 炭酸アパタイト・コラーゲン複合体を用いた骨再建に関する基礎的研究, 第62回日本口腔外科学会学術大会, 2017年10月.
64.	山村佳子, 玉谷哲也, 工藤景子, 福田直志, 中川貴之, 髙丸菜都美, 大江剛, 藤澤健司, 宮本洋二 : チタン上で培養したマウス骨芽細胞様細胞の硬組織分化にグルコース濃度が及ぼす影響, 第62回日本口腔外科学会学術大会, 2017年10月.
65.	福田直志, 秋田和也, 森悦秀, 宮本洋二 : 新規骨補填再建材としての自己硬化型β-TCP顆粒セメントの開発, 第62回日本口腔外科学会学術大会, 2017年10月.
66.	秋田和也, 福田直志, 大江剛, 藤澤健司, 宮本洋二, 都留寛治, 石川邦夫 : 新規骨再生材料としての炭酸アパタイト・コラーゲン複合体の開発, 第47回日本口腔インプラント学会学術大会, 2017年9月.
67.	藤澤健司, 秋田和也, 福田直志, 大江剛, 髙丸菜都美, 都留寛治, 石川邦夫, 宮本洋二 : 低結晶性炭酸アパタイト顆粒の骨再生への応用 –ウサギ大腿骨内における組織学的検討‐, 第47回日本口腔インプラント学会学術大会, 2017年9月.
68.	横田美保, 工藤景子, 玉谷哲也, 鎌田久美子, 福田直志, 髙丸菜都美, 山村佳子, 中川貴之, 大江剛, 工藤隆治, 高橋章, 藤澤健司, 鯨岡聡子, 工藤保誠, 石丸直澄, 宮本洋二 : 当科における歯原性角化嚢胞の臨床的検討, 第46回日本口腔外科学会中国四国学術集会, 2017年5月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

慢性炎症を組織修復環境に反転するナノ医薬による老化骨の治癒促進 (研究課題/領域番号: 23K18442 )
骨補填材兼GBR用スペーサー機能をもつ炭酸アパタイト／魚コラーゲンシートの開発 (研究課題/領域番号: 23K09372 )
マクロファージ局所制御機構を有する炭酸アパタイトの開発と骨再生機能低下の克服 (研究課題/領域番号: 23K09313 )
連通気孔の制御による自己硬化型β-TCP顆粒セメントの骨再生促進と骨造成への応用 (研究課題/領域番号: 21K17091 )
感染制御と骨再生を同時に可能とするハイブリッド型骨補填材による顎骨骨髄炎治療戦略 (研究課題/領域番号: 21K10095 )
カーボネイトアパタイトの高い骨伝導能・骨再生能を細胞の分子メカニズムから解明する (研究課題/領域番号: 21H03139 )
多孔質炭酸アパタイト・魚コラーゲン複合体をスキャフォールドとした戦略的骨再生治療 (研究課題/領域番号: 20K10180 )
頸部リンパ節転移の超早期検出への挑戦－転移可視化モデルの樹立と超音波診断法の構築 (研究課題/領域番号: 20K10140 )
自己硬化型β-TCP顆粒セメントによる垂直的骨造成への挑戦と骨再生医療への応用 (研究課題/領域番号: 19K19163 )
一方向連通気孔を持つ炭酸アパタイトによる顎骨再建と骨再生医療への応用 (研究課題/領域番号: 19K10333 )
ハイドロキシアパタイトの優れた骨伝導能とバイオインテグレーションの本質を解明する (研究課題/領域番号: 19K10290 )
放射線性顎骨壊死モデルの確立とスタチンの血管新生・骨形成作用による予防・治療戦略 (研究課題/領域番号: 19K10268 )
スポンジ状の弾性を有する新規炭酸アパタイト骨補填材の開発 (研究課題/領域番号: 18K09815 )
変形性顎関節症の新規治療法の開発を目指したLubricinの発現調節機構の解明 (研究課題/領域番号: 18K09769 )
スタチンの血管新生作用と骨形成作用による薬剤関連顎骨壊死の予防・治療法の開発 (研究課題/領域番号: 18K09746 )
骨置換性炭酸アパタイト多孔体と栄養血管を利用した皮膚と骨の複合的再生療法の開発 (研究課題/領域番号: 18H03002 )
出血部位でも硬化する新規骨補填再建材料としてのβ-TCP顆粒セメントの開発 (研究課題/領域番号: 17H06910 )
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助教 : 福田 直志

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

助教 : 福田直志