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徳島大学大学院医歯薬学研究部歯学域先端歯学教育研究プロジェクト
徳島大学大学院医歯薬学研究部歯学域口腔科学部門基礎歯学系組織再生制御学
徳島大学研究クラスター群研究クラスター群 (登録)1904003 間葉系幹細胞由来の再生因子を用いた,難治性変形性関節症に対する新規治療薬の開発
徳島大学歯学部歯学科基礎口腔科学講座組織再生制御学
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研究活動

個人のホームページ

専門分野

糖鎖生物学 (Glycobiology)

研究テーマ

可溶性Siglec-9の抗炎症・組織再生効果の解明 (再生医療, 免疫 (immunity), Siglec)

著書・論文

著書:

1. Furukawa Koichi, Ohmi Yuhsuke, Ohkawa Yuki, Noboru Hashimoto, Yamauchi Yoshio, Yajima Orie and Furukawa Keiko :
Gangliosides: Synthesis and function in nervous tissues,
Springer Japan, Jan. 2015.
2. 古川 鋼一, 大川 祐樹, 橋本 登, 大海 雄介, 古川 圭子 :
がん関連抗原としてのガングリオシド,
株式会社 羊土社, 2013年6月.

学術論文(審査論文):

1. Naoko Ogasawara, Fumiya Kano, Noboru Hashimoto, Hiroki Mori, YAO LIU, LINZE XIA, Takuma Sakamaki, Hideharu Hibi, Tsutomu Iwamoto, Eiji Tanaka and Akihito Yamamoto :
Factors Secreted from Dental Pulp Stem Cells Show Multifaceted Benefits for Treating Experimental Temporomandibular Joint Osteoarthritis,
Osteoarthritis and Cartilage, Vol.28, No.6, 831-841, 2020.
(徳島大学機関リポジトリ: 115291,   DOI: 10.1016/j.joca.2020.03.010,   PubMed: 32272195)
2. Koichi Furukawa, Yuhsuke Ohmi, Farhana Yesmin, Orie Tajima, Yuji Kondo, Pu Zhang, Noboru Hashimoto, Yuki Ohkawa, H Robiul Bhuiyan and Keiko Furukawa :
Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering.,
International Journal of Molecular Sciences, Vol.21, No.6, 2020.
(徳島大学機関リポジトリ: 115632,   DOI: 10.3390/ijms21061906,   PubMed: 32168753)
3. Keita Kawarabayashi, Fumiya Kano, Noboru Hashimoto, Hideharu Hibi, Tsutomu Iwamoto and Akihito Yamamoto :
Conditioned Media from Human Dental Pulp Stem Cells Prevent Radiation-induced Skin Injury.,
Journal of Oral Health and Biosciences, Vol.33, No.1, 1-7, 2020.
(徳島大学機関リポジトリ: 114712,   DOI: 10.20738/johb.33.1_1,   CiNii: 130007854090)
4. Noboru Hashimoto, Shizuka Ito, Akiko Tsuchida, H Robiul Bhuiyan, Tetsuya Okajima, Akihito Yamamoto, Keiko Furukawa, Yuhsuke Ohmi and Koichi Furukawa :
The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface.,
The Journal of Biological Chemistry, Vol.294, No.28, 10833-10845, 2019.
(DOI: 10.1074/jbc.RA118.007083,   PubMed: 31138648)
5. Robiul H. Bhuiyan, Yuhsuke Ohmi, Yuki Ohkawa, Pu Zhang, Maiko Takano, Noboru Hashimoto, Tetsuya Okajima, Keiko Furukawa and Koichi Furukawa :
Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice.,
Neuroscience, Vol.397, 94-106, 2018.
(DOI: 10.1016/j.neuroscience.2018.11.034,   PubMed: 30521973)
6. Koichi Furukawa, Yuhsuke Ohmi, Orie Tajima, Yuki Ohkawa, Yuji Kondo, Ji Shuting, Noboru Hashimoto and Keiko Furukawa :
Gangliosides in Inflammation and Neurodegeneration.,
Progress in Molecular Biology and Translational Science, Vol.156, 265-287, 2018.
(DOI: 10.1016/bs.pmbts.2018.01.009,   PubMed: 29747817)
7. Nobutoshi Esaki, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Tsuda, Yuhsuke Ohmi, Robiul H. Bhuiyan, Norihiro Kotani, Koichi Honke, Atsushi Enomoto, Masahide Takahashi, Keiko Furukawa and Koichi Furukawa :
ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer.,
Cancer Science, Vol.109, No.1, 141-153, 2018.
(DOI: 10.1111/cas.13448,   PubMed: 29151270)
8. Koichi Furukawa, Yuhsuke Ohmi, Shuting Ji, Pu Zhang, Robiul H. Bhuiyan, Yuki Ohkawa, Orie Tajima, Noboru Hashimoto and Keiko Furukawa :
Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis.,
Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1861, No.10, 2479-2484, 2017.
(DOI: 10.1016/j.bbagen.2017.06.007,   PubMed: 28602513)
9. Kei Kaneko, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Ohmi, Norihiro Kotani, Koichi Honke, Mitsutaka Ogawa, Tetsuya Okajima, Keiko Furukawa and Koichi Furukawa :
Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells.,
The Journal of Biological Chemistry, Vol.291, No.32, 16630-16643, 2016.
(DOI: 10.1074/jbc.M115.708834,   PubMed: 27288875)
10. Hasan Robiul Bhuiyan, Yuji Kondo, Tokiaki Yamaguchi, Noriyo Tokuda, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Ohmi, Yoshio Yamauchi, Keiko Furukawa, Tetsuya Okajima and Koichi Furukawa :
Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes.,
Glycobiology, Vol.26, No.9, 984-998, 2016.
(DOI: 10.1093/glycob/cww049,   PubMed: 27102283)
11. Reiko Ando, Noriyo Tokuda, Tokunori Yamamoto, Kazutaka Ikeda, Noboru Hashimoto, Ryo Taguchi, Xiaoen Fan, Keiko Furukawa, Yukio Niimura, Akemi Suzuki, Momokazu Goto and Koichi Furukawa :
Immunization of A4galt-deficient mice with glycosphingolipids from renal cell cancers resulted in the generation of anti-sulfoglycolipid monoclonal antibodies.,
Glycoconjugate Journal, Vol.33, No.2, 169-180, 2016.
(DOI: 10.1007/s10719-016-9654-6,   PubMed: 26883028)
12. Yuki Ohkawa, Hiroyuki Momota, Akira Kato, Noboru Hashimoto, Yusuke Tsuda, Norihiro Kotani, Koichi Honke, Akio Suzumura, Keiko Furukawa, Yuhsuke Ohmi, Atsushi Natsume, Toshihiko Wakabayashi and Koichi Furukawa :
Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase.,
The Journal of Biological Chemistry, Vol.290, No.26, 16043-16058, 2015.
(DOI: 10.1074/jbc.M114.635755,   PubMed: 25940087)
13. Kohki Matsubara, Yoshihiro Matsushita, Kiyoshi Sakai, Fumiya Kano, Megumi Kondo, Mariko Noda, Noboru Hashimoto, Shiro Imagama, Naoki Ishiguro, Akio Suzumura, Minoru Ueda, Koichi Furukawa and Akihito Yamamoto :
Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.,
The Journal of Neuroscience, Vol.35, No.6, 2452-2464, 2015.
(DOI: 10.1523/JNEUROSCI.4088-14.2015,   PubMed: 25673840,   Elsevier: Scopus)
14. Ilhamjan Sabit, Noboru Hashimoto, Yasuyuki Matsumoto, Toshiyuki Yamaji, Keiko Furukawa and Koichi Furukawa :
Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation.,
The Journal of Biological Chemistry, Vol.288, No.49, 35417-35427, 2013.
(DOI: 10.1074/jbc.M113.513192,   PubMed: 24145038)
15. Noriyo Tokuda, Shinichiro Numata, Xiaojin Li, Tomoko Nomura, Minoru Takizawa, Yuji Kondo, Yoriko Yamashita, Noboru Hashimoto, Tohru Kiyono, Takeshi Urano, Keiko Furukawa and Koichi Furukawa :
β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5.,
Glycobiology, Vol.23, No.10, 1175-1183, 2013.
(DOI: 10.1093/glycob/cwt054,   PubMed: 23882130)
16. Hiroshi Hotta, Kazunori Hamamura, Kyoko Yamashita, Hidenobu Shibuya, Noriyo Tokuda, Noboru Hashimoto, Keiko Furukawa, Noriyuki Yamamoto, Hisashi Hattori, Shinya Toyokuni, Minoru Ueda and Koichi Furukawa :
Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.,
Glycoconjugate Journal, Vol.30, No.6, 585-597, 2012.
(DOI: 10.1007/s10719-012-9458-2,   PubMed: 23242548)
17. Maiko Kurosawa, D Anand Jeyasekharan, Eva-Maria Surmann, Noboru Hashimoto, Vignesh Venkatraman, Gene Kurosawa, Koichi Furukawa, R Ashok Venkitaraman and Yoshikazu Kurosawa :
Expression of LY6D is induced at the surface of MCF10A cells by X-ray irradiation.,
The FEBS Journal, Vol.279, No.24, 4479-4491, 2012.
(DOI: 10.1111/febs.12034,   PubMed: 23075424)
18. Noboru Hashimoto, Kazunori Hamamura, Norihiro Kotani, Keiko Furukawa, Kei Kaneko, Koichi Honke and Koichi Furukawa :
Proteomic analysis of ganglioside-associated membrane molecules: substantial basis for molecular clustering.,
Proteomics, Vol.12, No.21, 3154-3163, 2012.
(DOI: 10.1002/pmic.201200279,   PubMed: 22936677)
19. Kazunori Hamamura, Momoko Tsuji, Hiroshi Hotta, Yuki Ohkawa, Masataka Takahashi, Hidenobu Shibuya, Hideyuki Nakashima, Yoshio Yamauchi, Noboru Hashimoto, Hisashi Hattori, Minoru Ueda, Keiko Furukawa and Koichi Furukawa :
Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.,
The Journal of Biological Chemistry, Vol.286, No.21, 18526-18537, 2011.
(DOI: 10.1074/jbc.M110.164798,   PubMed: 21454696)
20. Tomita Makoto, Noboru Hashimoto and Tanaka Yutaka :
Association study for the relationship between a haplotype or haplotype set and multiple quantitative responses,
Computational Statistics & Data Analysis, Vol.55, No.6, 2104-2113, 2011.
(DOI: 10.1016/j.csda.2011.01.002,   Elsevier: Scopus)

総説・解説:

1. Eiji Tanaka, YAO LIU, LINZE XIA, Naoko Ogasawara, Takuma Sakamaki, Fumiya Kano, Noboru Hashimoto, Xingmei Feng and Akihito Yamamoto :
Effectiveness of low-intensity pulsed ultrasound on osteoarthritis of the temporomandibular joint: A review.,
Annals of Biomedical Engineering, Vol.48, No.8, 2158-2170, Jun. 2020.
(DOI: 10.1007/s10439-020-02540-x,   PubMed: 32514932)
2. Koichi Furukawa, Yuhsuke Ohmi, Yuki Ohkawa, Robiul H. Bhuiyan, Pu Zhang, Orie Tajima, Noboru Hashimoto, Kazunori Hamamura and Keiko Furukawa :
New era of research on cancer-associated glycosphingolipids.,
Cancer Science, Vol.110, No.5, 1544-1551, Apr. 2019.
(徳島大学機関リポジトリ: 114571,   DOI: 10.1111/cas.14005,   PubMed: 30895683)

国際会議:

1. Noboru Hashimoto, Ito Shizuka, Ikeda Kazutaka, Tsuchida Akiko, Crocker R. Paul, Furukawa Keiko, Taguchi Ryo and Furukawa Koichi :
Structural specificity in molecular recognition of Siglec-7 to ganglioside GD3,
Gordon Reserch Conference Glycolipid &Sphingolipid Biology, Lucca (Barga), Italy, Mar. 2016.
2. Noboru Hashimoto, Kazunori Hamamura, Norihiro Kotani, Keiko Furukawa, Kei Kaneko, Koichi Honke and Koichi Furukawa :
Proteomic analysis of ganglioside-associated microdomain in malignant melanomas.,
2014 SFG & JSCR JOINT MEETING, Honolulu, Nov. 2014.
3. Noboru Hashimoto :
Proteomics of ganglioside GD3-containing microdomains in malignant melanomas,
Gordon Reserch Conference Glycolipid & Sphingolipid Biology, Ventura, CA, Jan. 2014.
4. Noboru Hashimoto, Hamamura Kazunori, Kotani Norihiro, Ohkawa Yuki, Furukawa Keiko, Honke Koichi and Furukawa Koichi :
Proteomic Profiling of Ganglioside-Associated Microdomain in Malignant Melanomas,
HUPO 12th Annual World Congress, Yokohama, Japan, Sep. 2013.

国内講演発表:

1. 橋本 登, 加納 史也, 河原林 啓太, LIU YAO, 夏 霖泽, 山本 朗仁 :
ヒト乳歯歯髄幹細胞由来培養液における皮膚炎モデルマウス治療効果因子のプロテオーム解析,
第41回日本炎症・再生医学会, 2020年7月.
2. 加納 史也, LIU YAO, 橋本 登, 松香 芳三, 田中 栄二, 山本 朗仁 :
歯髄幹細胞由来無血清培養上清は坐骨神経結紮モデルマウスの神経障害性疼痛を改善する,
日本炎症・再生医学会, 2020年7月.
3. 橋本 登, 加納 史也, 河原林 啓太, LIU YAO, 山本 朗仁 :
ヒト乳歯歯髄幹細胞由来培養液における皮膚炎モデルマウス治療効果因子のプロテオーム解析,
第19回日本再生医療学会総会, 2020年5月.
4. 加納 史也, 小笠原 直子, 橋本 登, 森 浩喜, 宮嵜 彩, 岩本 勉, 田中 栄二, 山本 朗仁 :
歯髄幹細胞由来無血清培養上清を用いた変形性顎関節症の治療法開発,
第19回日本再生医療学会, 20, 2020年3月.
5. 後野 秀一朗, 加納 史也, 有馬 秀貴, 橋本 登, 寺町 順平, 岩本 勉, 山本 朗仁 :
歯髄幹細胞由来無血清培養上清を用いた脊髄損傷の治療法開発,
徳島県歯科医学大会, 37, 2020年2月.
6. 有馬 秀貴, 加納 史也, 後野 秀一朗, 橋本 登, 寺町 順平, 岩本 勉, 山本 朗仁 :
間葉系幹細胞由来分泌因子がSchwann細胞の活性化に与える影響,
徳島県歯科医学大会, 36, 2020年2月.
7. 河原林 啓太, 加納 史也, 橋本 登, 寺町 順平, 青田 桂子, 東 雅之, 岩本 勉, 山本 朗仁 :
歯髄幹細胞由来無血清培養上清を用いた口腔乾燥症の治療法の開発,
徳島県歯科医学大会, 20, 2020年2月.
8. 小笠原 直子, 加納 史也, 橋本 登, LIU YAO, 森 浩喜, 寺町 順平, 岩本 勉, 田中 栄二, 山本 朗仁 :
歯髄幹細胞由来無血清培養上清を用いた変形性顎関節症の治療法開発,
徳島県歯科医学大会, 20, 2020年2月.
9. 小笠原 直子, 橋本 登, 山本 朗仁, 田中 栄二 :
変形性顎関節症に対するヒト脱落乳歯歯髄幹細胞由来無血清馴化培地の治療効果,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page183.(2019), 183, 2019年11月.
10. 橋本 登, 伊藤 静香, 土田 明子, H.Buiyan Robiul, 岡島 徹也, 山本 朗仁, 古川 圭子, 大海 雄介, 古川 鋼一 :
シアル酸結合レクチン Siglec7 のガングリオシド GD3 認識に対する セラミド構造の影響,
38, 2019年8月.
11. YAO RIU, 橋本 登, 寺町 順平, 松香 芳三, 田中 栄二, 山本 朗仁 :
乳歯歯髄幹細胞培養上清によるマウス坐骨神経結紮モデルにおける神経障害性疼痛の改善.,
第40回日本炎症・再生医学会, 2019年7月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

  • 乳歯歯髄幹細胞培養上清由来因子を用いた新規皮膚炎治療法の検討 (研究課題/領域番号: 20K08690 )
  • 分泌型Siglec-9とMCP-1による単球系細胞の炎症組織再生型移行機構の解明 (研究課題/領域番号: 17K15720 )
  • シグレックとシアル酸含有糖鎖が生成する自然免疫チェックポイントの機構解明 (研究課題/領域番号: 15K15080 )
  • Siglec-7と認識糖鎖の結合による癌の悪性形質増強と免疫監視逃避機構の解析 (研究課題/領域番号: 26860320 )
  • 研究者番号(90712365)による検索