Tokushima University / Educator and Researcher Directory --- Kurio, Naito

Personal Web Page

https://researchmap.jp/Tokushima-kurio (researchmap)

Field of Study

○	Oral and Maxillofacial Surgery

Subject of Study

○

Book / Paper

Book:

1.	Naito Kurio and Youji Miyamoto : 第5章口腔インプラント学のための基礎医学，Ⅲ外科手術，1「インプラント手術の準備と感染対策」, Ishiyaku Publishers,Inc., Feb. 2023.

Academic Paper (Judged Full Paper):

1.	Kumiko Kamada, Naito Kurio, Yasuhiro Mouri and Yasusei Kudo : Combination treatment with hyaluronic acid synthesis and Bcl-2 inhibitors induces senolytic elimination of oral squamous cell carcinoma cells in vitro., Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2024.
2.	Naito Kurio, Kumiko Kamada, Atsushi Uesugi, Takaaki Tsunematsu and Yasusei Kudo : 頬粘膜に発生した基底細胞腺腫の1例, 四国歯学会誌, Vol.37, No.1, 18-23, 2024.
3.	Akira Takahashi, Kumiko Kamada, Naoyuki Fukuda, Keiko Kudoh, Natsumi Takamaru, Naito Kurio, Chieko Sugawara and Youji Miyamoto : Analysis of the sublingual artery using contrast-enhanced computed tomography, Clinical Implant Dentistry and Related Research, Vol.25, No.3, 532-539, 2023. (Summary) This in vivo study aimed to clarify the position of the sublingual artery (SLA) relative to the mandibular bone and to infer the potential risk for injury during dental implant surgery. Contrast-enhanced computed tomography images of the mouth of 50 edentulous patients (100 sides) treated at Tokushima University Hospital were reviewed. Curved planar reconstructed images perpendicular to the alveolar ridge were processed and classified into molar, premolar, canine, and incisor regions. The SLA and its branches were identified, and the distance from the mandible to the SLA was measured. The SLA was located close to the mandible (<2 mm) in the molar, premolar, canine, and incisor segments in 12.0% (95% confidence interval 5.6%-18.4%), 20.6% (12.6%-28.7%), 30.5% (21.3%-39.8%), and 41.8% (28.8%-54.9%) cases, respectively. The SLA was located within ±3 mm craniocaudally to the upper wall of the mandibular canal in the molar and premolar regions in 50% of cases and within ±5 mm craniocaudally to the mylohyoid ridge in the canine and incisor regions in the other cases, with no sex or age-related differences. The vertical distance from the alveolar ridge to the SLA was influenced by sex and age owing to alveolar resorption, indicating that the alveolar ridge is not a reliable reference for predicting SLA position. As the risk of SLA injury always exist during dental implant placement and there is no way to confirm the SLA pathways in a patient, clinicians must avoid injuring the sublingual soft tissue. (Keyword) Dental Implants / Mandible / Alveolar Process / Tomography, X-Ray Computed / Cone-Beam Computed Tomography / Arteries (Link to Publication Site) ● Publication site (DOI): 10.1111/cid.13197 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36896477 ● Search Scopus @ Elsevier (PMID): 36896477 ● Search Scopus @ Elsevier (DOI): 10.1111/cid.13197 (DOI: 10.1111/cid.13197, PubMed: 36896477)
4.	Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Natsumi Takamaru, Naito Kurio, 石川邦夫 and Youji Miyamoto : Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure., Journal of Materials Science. Materials in Medicine, Vol.34, No.1, 2022. (Summary) Carbonate apatite (COAp) granules are useful as a bone substitute because they can be remodeled to new natural bone in a manner that conforms to the bone remodeling process. However, reconstructing large bone defects using COAp granules is difficult because of their granular shape. Therefore, we fabricated COAp honeycomb blocks (HCBs) with continuous unidirectional pores. We aimed to elucidate the tissue response and availability of COAp HCBs in the reconstruction of rabbit mandibular bone defects after marginal mandibulectomy. The percentages of the remaining COAp area and calcified bone area (newly formed bone) were estimated from the histological images. COAp area was 49.1 ± 4.9%, 30.3 ± 3.5%, and 25.5 ± 8.8%, whereas newly formed bone area was 3.0 ± 0.6%, 24.3 ± 3.3%, and 34.7 ± 4.8% at 4, 8, and 12 weeks, respectively, after implantation. Thus, COAp HCBs were gradually resorbed and replaced by new bone. The newly formed bone penetrated most of the pores in the COAp HCBs at 12 weeks after implantation. By contrast, the granulation tissue scarcely invaded the COAp HCBs. Some osteoclasts invaded the wall of COAp HCBs, making resorption pits. Furthermore, many osteoblasts were found on the newly formed bone, indicating ongoing bone remodeling. Blood vessels were also formed inside most of the pores in the COAp HCBs. These findings suggest that COAp HCBs have good osteoconductivity and can be used for the reconstruction of large mandibular bone defects. The COAp HCB were gradually resorbed and replaced by newly formed bone. (Keyword) Animals / Rabbits / Porosity / Apatites / Bone Substitutes / Bone and Bones / Porifera (Tokushima University Institutional Repository) ● Metadata: 118064 (Link to Publication Site) ● Publication site (DOI): 10.1007/s10856-022-06710-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36586041 ● Summary page in Scopus @ Elsevier: 2-s2.0-85145354870 (Tokushima University Institutional Repository: 118064, DOI: 10.1007/s10856-022-06710-2, PubMed: 36586041, Elsevier: Scopus)
5.	Yoshiko Yamamura, 鴨居耕平, Keiko Kudoh, Naito Kurio, Kumiko Kamada, 横田美保, Atsushi Uesugi and Youji Miyamoto : A Case of Ameloblastoma Removed Using a Three-dimensional Transparent Plastic Jaw Model Which Can Visualize Internal Jawbone Structures, Journal of Oral Health and Biosciences, Vol.35, No.1, 9-13, 2022. (Keyword) ameloblastoma / three-dimensional jaw model / three-dimensional printer / visualization (Tokushima University Institutional Repository) ● Metadata: 117597 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.35.1_9 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390293412207632768 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.35.1_9 (Tokushima University Institutional Repository: 117597, DOI: 10.20738/johb.35.1_9, CiNii: 1390293412207632768)
6.	Yoshiko Yamamura, Makoto Fukui, Takaharu Kudoh, 横田美保, Kumiko Kamada, Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : ピロカルピン塩酸塩を用いた口腔リンス法の有用性と安全性の検討, Oral Care, Vol.16, No.2, 52-56, 2022. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520579212289190912 (CiNii: 1520579212289190912)
7.	Go Ohe, Yasusei Kudo, Kumiko Kamada, Yasuhiro Mouri, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : Soluble Factor from Oral Cancer Cell Lines Inhibits Interferon-γ Production by OK-432 via CD40/CD40Ligand Pathway, Cancers, Vol.13, No.13, 2021. (Tokushima University Institutional Repository) ● Metadata: 116508 (Link to Publication Site) ● Publication site (DOI): 10.3390/cancers13133301 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85108890231 (Tokushima University Institutional Repository: 116508, DOI: 10.3390/cancers13133301, Elsevier: Scopus)
8.	Akira Takahashi, Kumiko Kamada, Keiko Kudoh, Takaharu Kudoh, Natsumi Takamaru, Naito Kurio, Chieko Sugawara and Youji Miyamoto : Evaluation of anatomical references for locating the course of the posterior superior alveolar artery for dental implant surgery, International Journal of Oral and Maxillofacial Surgery, Vol.51, No.2, 257-262, 2021. (Summary) This retrospective cohort study aimed to identify the best anatomical reference for predicting the posterior superior alveolar artery (PSAA) location. Computed tomographic images of 90 maxillary sinuses were evaluated. We studied five references, including the alveolar crest, maxillary sinus floor, zygomatoalveolar crest, hard palate and soft palate, and measured the distances between them and the PSAA. Variations in the distance were evaluated by the standard deviation and coefficient of variation (CV). The zygomatoalveolar crest was an unstable reference, owing to its high standard deviation and CV. The smallest CV was for the distance between the alveolar crest and PSAA, although the distance was smaller in edentulous jaws than dentulous jaws. The distance between the sinus floor and PSAA was larger in male and edentulous patients. The PSAA was detected in 40.0%, 44.4%, 54.4% and 56.7% of the sinus walls at the first and second premolar and the first and second molar positions, respectively. At these tooth positions, the respective heights above the hard palate were 11.2 ± 4.9, 8.2 ± 4.9, 6.2 ± 2.8 and 8.1 ± 2.9 mm. The hard palate was the most stable reference for predicting the location of the PSAA, irrespective of sex, age and dentition. (Keyword) Arteries / Cone-Beam Computed Tomography / Dental Implants / Humans / Male / Maxillary Sinus / Retrospective Studies / Sinus Floor Augmentation (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ijom.2021.05.013 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34083086 ● Summary page in Scopus @ Elsevier: 2-s2.0-85107155071 (DOI: 10.1016/j.ijom.2021.05.013, PubMed: 34083086, Elsevier: Scopus)
9.	Yoshiko Yamamura, Takamitsu Mano, Kumiko Kamada, 横田美保, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : A clinical study on malignant lymphomas arising in the oral region, Journal of Japan Society for Oral Tumors, Vol.33, No.2, 35-60, 2021. (Summary) We examined the clinical characteristics of 18 cases of malignant lymphomas arising in the oral region which were diagnosed at our department during the 11 years from 2008 to 2018. The patients consisted of 10 males and 8 females whose mean age was 70.2 years. The primary site was the upper gingiva in 10 cases (55.6%), and the initial symptoms were tumor mass and swelling in 15 cases (83.3%). Only 7 cases (38.9%) were clinically diagnosed as malignant lymphoma at first visit, but the other 11 cases were difficult to diagnose correctly. The various clinical symptoms such as mass formation and ulcer made differential diagnosis difficult, and a definitive diagnosis could not be obtained by only a single biopsy. Therefore, we examined whether blood test results might be used as an indicator of the diagnosis or not. Our results showed that LDH in 8 of 17 cases (47.1%) and sIL-2R in 11 of 16 cases (68.8%) were high values. Furthermore, we examined whether lymphocyte-monocyte ratio (LMR) helped the diagnosis or not. Thirteen of 17 cases (76.5%) showed a low value of LMR. There was a significant difference in LMR compared to non-malignant lymphoma patients. LMR in the blood tests was also considered to be a useful marker for the diagnosis. (Keyword) malignant lymphoma / clinical study / oral region / lymphocyte-monocyte ratio (Tokushima University Institutional Repository) ● Metadata: 116069 (Link to Publication Site) ● Publication site (DOI): 10.5843/jsot.33.35 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390851398293094784 ● Search Scopus @ Elsevier (DOI): 10.5843/jsot.33.35 (Tokushima University Institutional Repository: 116069, DOI: 10.5843/jsot.33.35, CiNii: 1390851398293094784)
10.	Takamitsu Mano, Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Naito Kurio, Kunio Ishikawa and Youji Miyamoto : Histological comparison of three apatitic bone substitutes with different carbonate contents in alveolar bone defects in a beagle mandible with simultaneous implant installation., Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.108, No.4, 1450-1459, 2020. (Summary) Since bone apatite is a carbonate apatite containing carbonate in an apatitic structure, carbonate content may be one of the factors governing the osteoconductivity of apatitic bone substitutes. The aim of this study was to evaluate the effects of carbonate content on the osteoconductivity of apatitic bone substitutes using three commercially available bone substitutes for the reconstruction of alveolar bone defects of a beagle mandible with simultaneous dental implant installation. NEOBONE, Bio-Oss, and Cytrans that contain 0.1, 5.5, and 12.0 mass% of carbonate, respectively, were used in this study. The amount of newly formed bone in the upper portion of the alveolar bone defect of the beagle's mandible was 0.7, 6.6, and 39.4% at 4 weeks after surgery and 4.7, 39.5, and 75.2% at 12 weeks after surgery for NEOBONE, Bio-Oss, and Cytrans, respectively. The results indicate that bone-to-implant contact ratio was the largest for Cytrans. Additionally, the continuity of the alveolar ridge was restored in the case of Cytrans, whereas the continuity of the alveolar ridge was not sufficient when using NEOBONE and Bio-Oss. Both Cytrans and Bio-Oss that have a relatively larger carbonate content in their apatitic structure was resorbed with time. We concluded that carbonate content is one of important factors governing the osteoconductivity of apatitic bone substitutes. (Tokushima University Institutional Repository) ● Metadata: 113813 (Link to Publication Site) ● Publication site (DOI): 10.1002/jbm.b.34492 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31622016 ● Search Scopus @ Elsevier (PMID): 31622016 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.34492 (Tokushima University Institutional Repository: 113813, DOI: 10.1002/jbm.b.34492, PubMed: 31622016)
11.	Naito Kurio, Kumiko Kamada, Takumi Kitagawa, Yasusei Kudo, Naozumi Ishimaru and Youji Miyamoto : A case of microcystic adnexal carcinoma arising in the upper gingiva, Japanese Journal of Oral & Maxillofacial Surgery, Vol.66, No.9, 455-459, 2020. (Summary) <p>Microcystic adnexal carcinoma (MAC) is a rare malignant tumor of skin appendages. MAC grows slowly, but is locally aggressive. The metastatic potential is low, but the recurrence rates are very high owing to insufficient dissection. The most common location of MAC is the skin of the midface of middle-aged adults. There has been no report about MAC arising in the gingiva. We report here an extremely rare case of MAC of the upper gingiva in a 53-year-old woman. She presented to our hospital with a 6-year history of a gradually increasing gingival mass. Intraoral examination revealed a smooth, poorly circumscribed mass with white granules resembling Fordyce spots on her upper gingiva. There was no bone destruction or regional lymph node swelling. The histopathological diagnosis was a tumor of skin appendages. Tumor resection was performed. Postoperative pathological examination revealed that the tumor differentiated into hair follicles and the sweat-gland-like structures and deeply infiltrated into muscle, perineural spaces, and bone. Since the surgical margins were positive, additional resection was performed after preoperative mapping biopsy. Finally, the tumor was completely excised. No tumor recurrence or metastasis have been observed over 1 year.</p> (Link to Publication Site) ● Publication site (DOI): 10.5794/jjoms.66.455 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1391975276372989696 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.66.455 (DOI: 10.5794/jjoms.66.455, CiNii: 1391975276372989696)
12.	Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Naito Kurio, Keiko Kudoh, Tsuru Kanji, Ishikawa Kunio and Youji Miyamoto : Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects, Journal of Biomedical Materials Research. Part A, Vol.108, No.3, 709-721, 2020. (Summary) Carbonate apatite (CO Ap) granules are known to show good osteoconductivity and replaced to new bone. On the other hand, it is well known that a porous structure allows bone tissue to penetrate its pores, and the optimal pore size for bone ingrowth is dependent on the composition and structure of the scaffold material. Therefore, the aim of this study was to fabricate various porous CO Ap granules through a two-step dissolution-precipitation reaction using CaSO as a precursor and 30-, 50-, 120-, and 205-μm diameter microfibers as porogen and to find the optimal pore size of CO Ap. Porous CO Ap granules were successfully fabricated with pore size 8.2-18.7% smaller than the size of the original fiber porogen. Two weeks after the reconstruction of rabbit calvarial bone defects using porous CO Ap granules, the largest amount of mature bone was seen to be formed inside the pores of CO Ap (120) [porous CO Ap granules made using 120-μm microfiber] followed by CO Ap (50) and CO Ap (30). At 4 and 8 weeks, no statistically significant difference was observed based on the pore size, even though largest amount of mature bone was formed in case of CO Ap (120). It is concluded, therefore, that the optimal pore size of the CO Ap is that of CO Ap (120), which is 85 μm. (Tokushima University Institutional Repository) ● Metadata: 114682 (Link to Publication Site) ● Publication site (DOI): 10.1002/jbm.a.36850 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31756282 ● Summary page in Scopus @ Elsevier: 2-s2.0-85076129237 (Tokushima University Institutional Repository: 114682, DOI: 10.1002/jbm.a.36850, PubMed: 31756282, Elsevier: Scopus)
13.	Naoyuki Fukuda, Kunio Ishikawa, Kazuya Akita, Kumiko Kamada, Naito Kurio, Yoshihide Mori and Youji Miyamoto : Effects of acidic calcium phosphate concentration on setting reaction and tissue response to β-tricalcium phosphate granular cement., Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 2019. (Summary) Beta-tricalcium phosphate granular cement (β-TCP GC), consisting of β-TCP granules and an acidic calcium phosphate (Ca-P) solution, shows promise in the reconstruction of bone defects as it sets to form interconnected porous structures, that is, β-TCP granules are bridged with dicalcium phosphate dihydrate (DCPD) crystals. In this study, the effects of acidic Ca-P solution concentration (0-600 mmol/L) on the setting reaction and tissue response to β-TCP GC were investigated. The β-TCP GC set upon mixing with its liquid phase, based on the formation of DCPD crystals, which bridged β-TCP granules to one another. Diametral tensile strength of the set β-TCP GC was relatively the same, at ∼0.6 MPa, when the Ca-P concentration was 20-600 mmol/L. Due to the setting ability, reconstruction of the rat's calvarial bone defect using β-TCP GC with 20, 200, and 600 mmol/L Ca-P solution was much easier compared to that with β-TCP granules without setting ability. Four weeks after the reconstruction, the amount of new bone was the same, ∼17% in both β-TCP GC and β-TCP granules groups. Cellular response to β-TCP granules and β-TCP GC using the 20 mmol/L acidic Ca-P solution was almost the same. However, β-TCP GC using the 200 and 600 mmol/L acidic Ca-P solution showed a more severe inflammatory reaction. It is concluded, therefore, that β-TCP GC, using the 20 mmol/L acidic Ca-P solution, is recommended as this concentration allows surgical techniques to be performed easily and provides good mechanical strength, and the similar cellular response to β-TCP granules. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B, 2019. (Tokushima University Institutional Repository) ● Metadata: 116068 (Link to Publication Site) ● Publication site (DOI): 10.1002/jbm.b.34361 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30884116 ● Search Scopus @ Elsevier (PMID): 30884116 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.34361 (Tokushima University Institutional Repository: 116068, DOI: 10.1002/jbm.b.34361, PubMed: 30884116)
14.	Youji Miyamoto, Kazuya Akita, 福田直之, Kumiko Kamada and Naito Kurio : 新規骨補填材としての炭酸アパタイトの開発と骨再生医療に向けて, Journal of the Japanese Academy of Maxillofacial Prosthetics, Vol.41, No.2, 15-19, 2018.

Review, Commentary:

1.	Youji Miyamoto, Naoyuki Fukuda, Kazuya Akita, Keiko Kudoh and Naito Kurio : 骨補填材としての炭酸アパタイトの現状と今後の展開, Japanese Journal of MaxilloFacial Implants, Vol.20, No.2, 88-95, Aug. 2021. (Summary) A main inorganic component of human bone is not hydroxyapatite but carbonate apatite (CQ3Ap). Hydroxyapatite is not resorbed in the body but C03Ap can be resorbed and replaced with bone. We have succeeded in fabricating low crystalline CQ3Ap without sintering by dissolution-precipitation reaction using calcium hydroxide as a precursor. C03Ap showed excellent biocompatibility and faster bone formation compared to other bone substitutes (anorganic bovine bone and hydroxyapatite) in rabbit femur and dog mandible. Clinical study on effectiveness and safety of C03Ap granules in sinus floor augmentation was successfully concluded in 2016. CQ3Ap granules were approved by Japanese government in 2017, and marketed in 2018 as Cytrans® Granules. This comprehensive review explains the clinical cases of sinus lift and alveolar ridge augmentation of Cytrans® and its recommended clinical usage. Furthermore, we have succeeded in developing porous C03Ap and showed it was useful for reconstruction of mandibular bone defect in rabbit model and also aim to use it as a scaffold for bone regenerative medicine. (Keyword) apatite / bone substitute / bone regenerative medicine / carbonate apatite / アパタイト / 骨補填材 / 骨再生医療 / 炭酸アパタイト (Tokushima University Institutional Repository) ● Metadata: 116329 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1010576118550922112 (Tokushima University Institutional Repository: 116329, CiNii: 1010576118550922112)
2.	Youji Miyamoto, Naito Kurio, Keiko Kudoh and Natsumi Takamaru : -, Journal of Japanese Society of Oral Implantology, Vol.34, No.1, 26-32, Mar. 2021. (Keyword) 歯科インプラント / 医療事故 / 手術手技 / dental implant / medical accident / operative procedure (Link to Publication Site) ● Publication site (DOI): 10.11237/jsoi.34.26 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390287827491626624 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.34.26 (DOI: 10.11237/jsoi.34.26, CiNii: 1390287827491626624)

Proceeding of International Conference:

1.	Takamitsu Mano, Naoyuki Fukuda, Kazuya Akita, Kumiko Kamada, Naito Kurio and Youji Miyamoto : Comparative Study On Tissue Response To Low Crystalline Carbonate Apatite, NEOBONE® And Bio-Oss® In A Dog Model, 24th Congress of the European Association for Cranio Maxillo Facial Surgery, Sep. 2018.

Proceeding of Domestic Conference:

1.	Naoyuki Fukuda, Natsumi Takamaru, Kazuya Akita, Keiko Kudoh and Naito Kurio : 顎骨嚢胞摘出後の骨欠損再建に使用した炭酸アパタイト骨補填材の評価, 第69回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2024.
2.	Naito Kurio, Kumiko Kamada, Naoyuki Fukuda and Natsumi Takamaru : 顎変形症の術後管理中に解離性てんかん発作を発症した一例, 第34回日本顎変形症学会総会・学術大会, Jun. 2024.
3.	赤井享輔, Kumiko Kamada, Atsushi Uesugi and Naito Kurio : 咀嚼困難を契機に診断された重症筋無力症の一例, 第53回口腔外科学会中国四国支部学術集会, Jun. 2024.
4.	Akira Takahashi, Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Naito Kurio, Chieko Sugawara and Youji Miyamoto : Analysis of the sublingual artery using contrast-enhanced computed tomography, 日本歯科放射線学会第64回学術大会, Vol.64, 40, May 2024. (Keyword) computed tomography / dental implants / floor of the mouth / lingual perimandibular vessels / oral hemorrhage / postoperative bleeding / sublingual artery
5.	Takaharu Kudoh, Keiko Kudoh, Natsumi Takamaru, Akira Takahashi, Naito Kurio, Chisato Tonoiso, Akiko Kubo, Takashi Kawanaka, Youji Miyamoto and Hitoshi Ikushima : Unilateral Neck Volumetric-Modulated Arc Therapy, 日本歯科放射線学会第64回学術大会, May 2024.
6.	Susumu Abe, Naito Kurio, Yoritoki Tomotake, Kumiko Kamada, Toshinori Okawa, Eiji Yamauchi, Youji Miyamoto and Tetsuo Ichikawa : A case of implant-supported overdenture for severe bone defect of the mandible and vascularized fibular graft by carcinoma of the lower gingiva, 日本口腔インプラント学会誌第43回関東・甲信越支部学術大会, 105, Feb. 2024.
7.	Naito Kurio, Kumiko Kamada, Atsushi Uesugi, 横田美保, 赤井亨輔, Yoshiko Yamamura, Akira Takahashi and Youji Miyamoto : ヒアルロン酸阻害薬による口腔扁平上皮癌細胞の老化誘導とsenolytic therapy, 第68回日本口腔外科学会総会・学術大会, Nov. 2023.
8.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, Takaharu Kudoh, Naito Kurio and Youji Miyamoto : 炭酸アパタイト製骨補填材の炭酸基量を変えることによる吸収性と骨新生のコントロール, 第68回日本口腔外科学会総会・学術大会, Nov. 2023.
9.	Atsushi Uesugi, Naito Kurio, 赤井亨輔, 横田美保, Kumiko Kamada and 宮本洋二 : A case of recurrent ameloblastoma in the mandibular ramus resected using a high perimandibular approach, 第52回日本口腔外科学会中国四国支部学術集会, Jul. 2023.
10.	Natsumi Takamaru, Naoyuki Fukuda, Naito Kurio and Youji Miyamoto : 顎矯正手術患者の術後悪心嘔吐に対するオンダンセトロンの有用性の検討, 第33回特定非営利活動法人日本顎変形症学会総会・学術大会, Jun. 2023.
11.	Keiichiro Watanabe, Emiko Nakaue, Kumiko Kamada, Natsumi Takamaru, Naito Kurio and Eiji Tanaka : 3DシミュレーションとCAD/CAMスプリントを用いて上下顎移動術を施行した顎偏位を伴う骨格性下顎前突の1例, The Japanese Journal of Jaw Deformities, Vol.33, No.2, 174, May 2023. (Keyword) 顎前突症(合併症, 外科的療法, 診断) / スプリント, 不正咬合-アングルIII級(合併症, 外科的療法, 診断) / コンピュータ支援設計, コンピュータシミュレーション / 三次元イメージング, 顎矯正手術 / ヒト; 成人(19∼44); 女; 歯学
12.	Yoshiko Yamamura, Yasuhiro Mouri, Kumiko Kamada, Naito Kurio, Keiko Kudoh, Yasusei Kudo and Youji Miyamoto : 唾液腺の発達・再生におけるNrepの役割, 第77回NPO法人日本口腔科学会学術集会, May 2023.
13.	Naoyuki Fukuda, Kazuya Akita, Kumiko Kamada, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : 炭酸アパタイト製骨補填材を用いた上顎洞底挙上術後の長期予後について, 公益社団法人日本口腔インプラント学会第42回中国・四国支部学術大会, Nov. 2022.
14.	Atsushi Uesugi, Naito Kurio, Kumiko Kamada, 横田美保, Keiko Kudoh and Youji Miyamoto : 機能的スクリーニングによる新規の口腔癌関連癌抑制microRNAの検索, 第67回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2022.
15.	Yoshiko Yamamura, Naito Kurio, Kumiko Kamada, Takaharu Kudoh, Akira Takahashi, Keiko Kudoh and Youji Miyamoto : チタン製インプラント体のオッセオインテグレーション獲得に関与するmiRNAの検索, 第67回日本口腔外科学会総会・学術大会, Nov. 2022.
16.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Takaharu Kudoh, Keiko Kudoh, Naito Kurio and Youji Miyamoto : 炭酸基量の異なる多孔質炭酸アパタイト顆粒の開発と骨再建, 第67回日本口腔外科学会総会・学術集会, Nov. 2022.
17.	Kumiko Kamada, Naito Kurio, Atsushi Uesugi, Yoshiko Yamamura and Youji Miyamoto : 口腔扁平上皮癌細胞株に対するヒアルロン酸合成阻害の抗腫瘍効果, 第67回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2022.
18.	Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Takaharu Kudoh, Natsumi Takamaru, Naito Kurio and Youji Miyamoto : ハニカム構造を有する炭酸アパタイト多孔体によるウサギ下顎骨再建への応用, 第67回日本口腔外科学会総会・学術大会, Nov. 2022.
19.	横田美保, Naito Kurio, Kumiko Kamada, Atsushi Uesugi and Youji Miyamoto : 翼突鉤切除を行ったPterygoid hamulus bursitisの1例, 第69回(公社)日本口腔科学会中国四国支部学術集会, Oct. 2022.
20.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Takaharu Kudoh, Keiko Kudoh, Naito Kurio, Akira Takahashi and Youji Miyamoto : 炭酸アパタイト顆粒(サイトランスグラニュール)の歯槽骨造成術およびソケットプリザベーションへの応用, 第50回(公社)日本口腔外科学会中国四国支部学術集会, Jan. 2022.
21.	Kumiko Kamada, Naito Kurio, Atsushi Uesugi, 横田美保, Kazuya Akita, Naoyuki Fukuda, Yoshiko Yamamura, Takaharu Kudoh, Natsumi Takamaru, Keiko Kudoh, Akira Takahashi and Youji Miyamoto : 歯性感染症により発症した側頭部ガス壊疽の1例, 第50回(公社)日本口腔外科学会中国四国支部学術集会, Jan. 2022.
22.	Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Atsushi Uesugi, Yoshiko Yamamura, Takaharu Kudoh, Natsumi Takamaru, Keiko Kudoh, Naito Kurio, Akira Takahashi and Youji Miyamoto : 炭酸アパタイト顆粒(サイトランスグラニュール)を用いて歯槽骨造成を行った2例, 第68 回NPO 法人日本口腔科学会中国・四国地方部会, Nov. 2021.
23.	Yoshiko Yamamura, Yasusei Kudo, Kumiko Kamada, Naito Kurio, 横田美保, Atsushi Uesugi and Youji Miyamoto : 唾液腺の発達・再生におけるΔNp63-Nrep axisの役割, 第66回日本口腔外科学会総会・学術大会, Nov. 2021.
24.	Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Takaharu Kudoh, 椋本修平, Natsumi Takamaru, Naito Kurio, Kumiko Kamada and Youji Miyamoto : 炭酸アパタイト顆粒と魚うろこコラーゲンの複合化による新規骨補填材の開発, 第66回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2021.
25.	Kumiko Kamada, Naito Kurio, Naoyuki Fukuda, 横田美保, Kazuya Akita, Atsushi Uesugi, Yoshiko Yamamura, Takaharu Kudoh, Akira Takahashi and 宮本洋二 : 口腔癌術後に多発肺結節を認めた敗血症性肺塞栓症の一例, 第49回(公社)日本口腔外科学会中国四国支部学術集会, Feb. 2021.
26.	Natsumi Takamaru, Naoyuki Fukuda, Kumiko Kamada, Kazuya Akita, Go Ohe, Naito Kurio and Youji Miyamoto : 早期口腔扁平上皮癌におけるPD-L1とZEB-1の発現と予後との関連について, 第65回日本口腔外科学会総会・学術大会, Nov. 2020.
27.	Naoyuki Fukuda, Keiko Kudoh, Kazuya Akita, Takaharu Kudoh, Natsumi Takamaru, Go Ohe, Naito Kurio and Youji Miyamoto : 一方向連通気孔を有する炭酸アパタイトハニカムブロックの開発と顎骨再建への応用, 第65回日本口腔外科学会総会・学術大会, Nov. 2020.
28.	Yoshiko Yamamura, Takamitsu Mano, Naito Kurio, Takaharu Kudoh, Keiko Kudoh, Naoyuki Fukuda and Youji Miyamoto : ピロカルピン塩酸塩を用いた口腔リンス法の有用性と安全性の検討, 第17回日本口腔ケア学会総会・学術大会, Sep. 2020.
29.	Keiko Kudoh, 秋田和也, Naoyuki Fukuda, Takaharu Kudoh, Naito Kurio, Go Ohe, Takamitsu Mano and Youji Miyamoto : 新規骨補填材としての炭酸アパタイトの開発と骨再生医療への応用, 徳島県歯科医学大会, Feb. 2020.
30.	Naito Kurio, Kumiko Kamada, 横田美保, Yoshiko Yamamura, Aya Ushio, Yasusei Kudo, Naozumi Ishimaru and Youji Miyamoto : 上顎歯肉に発生した微小嚢胞性付属器癌の1例, 第38回日本口腔腫瘍学会総会・学術大会, Jan. 2020.
31.	Yoshiko Yamamura, Go Ohe, Yasusei Kudo, Naito Kurio, 鎌田久美子, Naoyuki Fukuda, Keiko Kudoh, Takamitsu Mano, Naozumi Ishimaru and Youji Miyamoto : 口腔扁平苔癬からの癌化が疑われた口腔扁平上皮癌の4例, 第38回日本口腔腫瘍学会総会・学術大会, Jan. 2020.
32.	Kumiko Kamada, Naito Kurio, Go Ohe, Keiko Kudoh, Yasusei Kudo, Takamitsu Mano, Naozumi Ishimaru and Youji Miyamoto : 口底に発生した類基底扁平上皮癌の1例, 第38回日本口腔腫瘍学会総会・学術大会, Jan. 2020.
33.	Kazuya Akita, Naoyuki Fukuda, 鎌田久美子, Yoshiko Yamamura, Keiko Kudoh, Takaharu Kudoh, Naito Kurio, Go Ohe, Takamitsu Mano and Youji Miyamoto : ナイロンファイバーをポロゲンとして用いた炭酸アパタイト多孔体の開発と骨再建, 第64回日本口腔外科学会総会・学術大会, Oct. 2019.
34.	Kumiko Kamada, Naito Kurio, Go Ohe, Keiko Kudoh, Yoshiko Yamamura, Naoyuki Fukuda, Takamitsu Mano, Yasusei Kudo, Naozumi Ishimaru and Youji Miyamoto : 上顎歯肉に発生したMicorocystic adnexal carcinoma(MAC)の1例, 第64回日本口腔外科学会総会・学術大会, Oct. 2019.
35.	Yoshiko Yamamura, Tetsuya Tamatani, Keiko Kudoh, Naito Kurio, 鎌田久美子, Go Ohe, Takamitsu Mano and Youji Miyamoto : チタン上で培養したマウス骨芽細胞様細胞のmirVana miRNA-155-5p発現解析, 第64回日本口腔外科学会総会・学術大会, Oct. 2019.
36.	Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Takaharu Kudoh, Go Ohe, Naito Kurio, Yoshiko Yamamura, 鎌田久美子, Takamitsu Mano and Youji Miyamoto : ハニカム構造を有する炭酸アパタイト多孔体の開発と下顎骨再建への応用, 第64回日本口腔外科学会総会・学術大会, Oct. 2019.
37.	Naito Kurio, 鎌田久美子, Go Ohe, 横田美保, Yoshiko Yamamura, Keiko Kudoh, Yasusei Kudo, Takamitsu Mano, Naozumi Ishimaru and Youji Miyamoto : 歯肉腫瘤により白血病化が明らかとなった骨髄異形成症候群の1例, 第67回日本口腔科学会中国・四国地方部会, Oct. 2019.
38.	Takaharu Kudoh, Keiko Kudoh, 鎌田久美子, Naoyuki Fukuda, Yoshiko Yamamura, Naito Kurio, Takamitsu Mano and Youji Miyamoto : Radiomicsを用いた舌癌の頸部リンパ節転移の予測, 第67回日本口腔科学会中国・四国地方部会, Oct. 2019.
39.	鎌田久美子, Naito Kurio, Go Ohe, Yoshiko Yamamura, Keiko Kudoh, Yasusei Kudo, Naozumi Ishimaru and Youji Miyamoto : 口底に発生した類基底扁平上皮癌の1例, 第18回中四国口腔癌研究会, Oct. 2019.
40.	Kumiko Kamada, Naito Kurio, Keiko Kudoh, Yoshiko Yamamura, Naoyuki Fukuda, Takayuki Nakagawa, Go Ohe, Takamitsu Mano and Youji Miyamoto : 開口障害を主訴に来院した破傷風の1症例, 第48回(公社)日本口腔外科学会中国四国支部学術集会, May 2019.
41.	Keiko Kudoh, 鎌田久美子, Yoshiko Yamamura, Go Ohe, Naito Kurio, Kazuya Akita, Takaharu Kudoh, Akira Takahashi, Takamitsu Mano and Youji Miyamoto : 上顎洞内異物迷入8症例の臨床的検討, 第48回(公社)日本口腔外科学会中国四国支部学術集会, May 2019.
42.	Naito Kurio, Kumiko Kamada, Yoshiko Yamamura, Keiko Kudoh and Youji Miyamoto : 潰瘍性大腸炎の合併症と考えれらた難治性口腔潰瘍の一例, 第73回日本口腔科学会学術集会, Apr. 2019.
43.	榊原健人, Takayuki Nakagawa, Naoyuki Fukuda, Naito Kurio, Tetsuya Tamatani, Takamitsu Mano, 大塚邦紘, Yasusei Kudo, Naozumi Ishimaru and Youji Miyamoto : 下顎骨に発生した腺性歯原性嚢胞の1例, 第66回日本口腔科学会中国・四国地方部会, Nov. 2018.
44.	Natsumi Takamaru, Tetsuya Tamatani, 鎌田久美子, 秋田和也, Naito Kurio, Takayuki Nakagawa, Go Ohe and Youji Miyamoto : 舌扁平上皮癌におけるPD-L1とZEB-1の発現と予後との関連について, Nov. 2018.
45.	Yoshiko Yamamura, Tetsuya Tamatani, Keiko Kudoh, Kumiko Kamada, Takaharu Kudoh, Naito Kurio, Go Ohe, Natsumi Takamaru and Youji Miyamoto : 唾液腺の委縮により誘導される遺伝子およびマイクロRNA 発現の変化, 第63回日本口腔外科学会総会・学術大会, Nov. 2018.
46.	横田美保, Go Ohe, Tetsuya Tamatani, 秋田和也, 鎌田久美子, Natsumi Takamaru, Naito Kurio, 大塚邦紘, Yasusei Kudo and Youji Miyamoto : 当科におけるエナメル上皮腫の臨床統計学的検討, 第47回(公社)日本口腔外科学会中国四国支部学術集会, Jun. 2018.
47.	鎌田久美子, Naito Kurio, Keiko Kudoh, Takayuki Nakagawa, Go Ohe, 秋田和也, Naoyuki Fukuda, Natsumi Takamaru, Tetsuya Tamatani, Takamitsu Mano and Youji Miyamoto : 炭酸アパタイト顆粒(サイトランス○REAグラニュール)の上顎洞底挙上術への応用 -インプラント体同時埋入症例-, 第47回(公社)日本口腔外科学会中国四国支部学術集会, Jun. 2018.
48.	Yoshiko Yamamura, Tetsuya Tamatani, Takaharu Kudoh, 鎌田久美子, Keiko Kudoh, Natsumi Takamaru, Go Ohe, Kenji Fujisawa, Takayuki Nakagawa, Naito Kurio, Takamitsu Mano and Youji Miyamoto : 放射線治療患者におけるピロカルピン塩酸塩を用いた口腔リンス法の有用性, 第16回中国四国口腔癌研究会, Nov. 2017.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

がん抑制型microRNAの経皮投与による新規治療法の開発 (Project/Area Number: 24K13158 )
頸部リンパ節転移の超早期診断の挑戦-転移可視化モデルの樹立と超音波診断法の構築 (Project/Area Number: 24K13133 )
ヒアルロン酸合成阻害剤による口腔癌のBcl2発現増強を標的とした老化細胞除去療法 (Project/Area Number: 24K13090 )
骨補填材兼GBR用スペーサー機能をもつ炭酸アパタイト／魚コラーゲンシートの開発 (Project/Area Number: 23K09372 )
機能的スクリーニングから独自に選出した新規microRNAによる口腔癌治療の開発 (Project/Area Number: 21K10140 )
Lubricinによる変形性顎関節症に対する新規治療法の開発 (Project/Area Number: 21K10096 )
カーボネイトアパタイトの高い骨伝導能・骨再生能を細胞の分子メカニズムから解明する (Project/Area Number: 21H03139 )
Strategic bone reproduction using scaffold of porous carbonate apatite granules/fish-derived collagen composite (Project/Area Number: 20K10180 )
Establishment of visualizing oral cancer model and development of clinical ultrasonographic examination which detects initial cervical metastatic lymph node by oral cancer (Project/Area Number: 20K10140 )
Application in jaw bone reconstruction and bone regenerative medicine by uniaxially porous carbonate apatite (Project/Area Number: 19K10333 )
We elucidate the excellent osteoconductivity of hydroxyapatite (Project/Area Number: 19K10290 )
Fabrication of a new spongiform elasticity bone substitue using carbonate apatite (Project/Area Number: 18K09815 )
3種類のサンプリングによるアレイ解析を用いた口腔癌のセツキシマブ耐性化機構の解明 (Project/Area Number: 18K09792 )
Elucidation of the expression and regulation mechanisms of Lubricin aiming at the development of a new treatment for osteoarthritis of the jaw (Project/Area Number: 18K09769 )
Development of prevention and treatment of medication-related osteonecrosis of the jaw by angiogenic and osteogenic effects of statins (Project/Area Number: 18K09746 )
Identification of Metastasis-specific miRNAs and Establishment of Diagnostic Methods Focusing on Cancer Stem Cells and Blood of Patients with Oral Cancer Metastasis (Project/Area Number: 18K09745 )
Fabrication of the bone and soft tissue regenerative medicine using porous carbonate apatite with replacement to new bone and blood vessels (Project/Area Number: 18H03002 )
2型糖尿病治療薬メトホルミン塩酸塩の口腔癌における骨浸潤・骨破壊に与える影響 (Project/Area Number: 26861721 )
Development of new therapies targeting SHH in oral cancer jaw bone destruction and its application to personalized medicine (Project/Area Number: 26293428 )
The Role of Insulin-Iike Growth Factor-I Receptor in Oral Cancer Induced Bone Destruction (Project/Area Number: 24792216 )
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Associate Professor : Kurio, Naito

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)