徳島大学 / 教育研究者総覧 --- 伊藤浩敬

専門分野

研究テーマ

著書・論文

著書:

1.	伊藤浩敬, 山田博胤 : Ⅴ心臓疾患心膜炎の分類と疫学, 2019年9月.
2.	伊藤浩敬, 山田博胤 : 心膜炎の分類と疫学, 2019年.

学術論文(審査論文):

1.	Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Y Tsuruo and Masataka Sata : Association of Microluminal Structures Assessed by Optical Coherence Tomography With Local Inflammation in Adjacent Epicardial Adipose Tissue and Coronary Plaque Characteristics in Fresh Cadavers, Circulation Journal, Vol.87, No.2, 329-335, 2023. (要約) Coronary intraplaque microluminal structures (MS) are associated with plaque vulnerability, and the inward progression of vascular inflammation from the adventitia towards the media and intima has also been demonstrated. Therefore, in the present study we investigated the relationships among MS, local inflammation in adjacent epicardial adipose tissue (EAT), and coronary plaque characteristics.Methods and Results: Optical coherence tomography (OCT) revealed MS in the left anterior descending coronary artery in 10 fresh cadaveric hearts. We sampled 30 lesions and subdivided them based on the presence of MS: MS (+) group (n=19) and MS (-) group (n=11). We measured inflammatory molecule levels in the adjacent EAT and percentage lipid volume assessed by integrated backscatter intravascular ultrasound in each lesion. The expression levels of vascular endothelial growth factor B and C-C motif chemokine ligand 2 were significantly higher in the MS (+) group than in the MS (-) group (0.9±0.7 vs. 0.2±0.2 arbitrary units (AU), P=0.04 and 1.5±0.5 vs. 0.6±0.7 AU, P=0.02, respectively). Percentage lipid volume was significantly higher in the MS (+) group than in the MS (-) group (38.7±16.5 vs. 23.7±10.9%, P=0.03). Intraplaque MS observed on OCT were associated with lipid-rich plaques and local inflammation in the adjacent EAT. Collectively, these results suggest that local inflammation in the EAT is associated with coronary plaque vulnerability via MS. (徳島大学機関リポジトリ) ● Metadata: 117602 (出版サイトへのリンク) ● Publication site (DOI): 10.1253/circj.CJ-22-0299 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244741 ● Search Scopus @ Elsevier (PMID): 36244741 ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-22-0299 (徳島大学機関リポジトリ: 117602, DOI: 10.1253/circj.CJ-22-0299, PubMed: 36244741)
2.	Yutaka Kawabata, Takeshi Soeki, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, M Kitani, K Kawano, Y Taketani and Masataka Sata : Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II-Renin Feedback in Hypertensive Patients, International Journal of Hypertension, 6653851, 2020. (徳島大学機関リポジトリ) ● Metadata: 115937 (出版サイトへのリンク) ● Publication site (DOI): 10.1155/2020/6653851 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33489354 ● Summary page in Scopus @ Elsevier: 2-s2.0-85098701678 (徳島大学機関リポジトリ: 115937, DOI: 10.1155/2020/6653851, PubMed: 33489354, Elsevier: Scopus)
3.	Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Yoshihiro Tsuruo and Masataka Sata : Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers, Circulation Journal, Vol.84, No.5, 769-775, 2020. (徳島大学機関リポジトリ) ● Metadata: 116640 (出版サイトへのリンク) ● Publication site (DOI): 10.1253/circj.CJ-19-0914 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32281556 ● Summary page in Scopus @ Elsevier: 2-s2.0-85083919450 (徳島大学機関リポジトリ: 116640, DOI: 10.1253/circj.CJ-19-0914, PubMed: 32281556, Elsevier: Scopus)
4.	Shusuke Yagi, Daisuke Kondo, Takayuki Ise, Daiju Fukuda, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, Yoshihito Saijo, Hiromitsu Seno, Kumiko Sutou, Rie Ueno, Takafumi Todoroki, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Ken-ichi Aihara, Masashi Akaike and Masataka Sata : Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome, Journal of Atherosclerosis and Thrombosis, Vol.26, No.3, 272-281, 2019. (要約) It is speculated that statin therapy modulates the synthesis of polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, the data available on the effects of statin therapy on the serum levels of PUFA and the subsequent impact on in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) are limited. A total of 120 ACS patients who received emergent coronary stent implantation, follow-up coronary angiography to evaluate ISR, and new statin therapy were enrolled. We measured the serum levels of the PUFA and lipids at the onset of ACS and at the follow-up coronary angiography. The follow-up coronary angiography revealed 38 ISR cases. New statin therapy significantly reduced the serum levels of DHA and low-density lipoprotein cholesterol (LDL-C), while it did not affect EPA level. Single regression analysis revealed that a decreased serum level of LDL-C was associated with decreased DHA level. The multiple logistic regression analysis revealed that the decreased DHA level after statin therapy and low serum level of EPA on admission were determinants of prevalence of ISR. Statin therapy decreased the serum level of DHA with a parallel reduction in LDL-C level in patients with ACS. Decreased DHA level after statin therapy and low EPA level on admission are risk factors for ISR, indicating that in patients with ACS, decreased serum levels of DHA may be a residual target for the prevention of ISR. (キーワード) Acute Coronary Syndrome / Aged / Coronary Restenosis / Docosahexaenoic Acids / Eicosapentaenoic Acid / 女性 (female) / Follow-Up Studies / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors / 男性 (male) / Prognosis / Retrospective Studies / Risk Factors / Stents (徳島大学機関リポジトリ) ● Metadata: 113220 (出版サイトへのリンク) ● Publication site (DOI): 10.5551/jat.44735 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30135329 ● Summary page in Scopus @ Elsevier: 2-s2.0-85062425735 (徳島大学機関リポジトリ: 113220, DOI: 10.5551/jat.44735, PubMed: 30135329, Elsevier: Scopus)
5.	高橋未奈, 飛梅威, 松本和久, 松浦朋美, 添木武, 藤本裕太, 原田貴文, Zheng Robert, 數藤久美子, 西條良仁, 上野理絵, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 轟貴史, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 : 大動脈弁人工弁(機械弁)置換術後遠隔期に生じたOMI-VT stormに対し経心房中隔的に施行したカテーテルアブレーションが著効した1例, 四国医学雑誌, Vol.74, No.56, 201-208, 2019年. (要約) A 68-year-old woman with VT storm and frequent appropriate ICD therapy was referred for catheter ablation. Her past history was notable for aortic valve replacement by mechanical valve due to infectious endocarditis 17 years prior to presentation and left ventricular apical old myocardial infarction with unknown onset. At 67 years old, She admitted to the prior hospital due to ventricular tachycardia with LBBB and superior axis at heart rate of 210 per minutes. Administration of amiodarone and magnesium sulfate was ineffective and cardioversion of 200J was successfully terminated the tachycardia. Intra-cardiac defibrillator was implanted and the administration of amiodarone and mexiletine was started. 5 months after, she admitted to the hospital due to the frequent appropriate shock against the same ventricular tachycardia. Administration of lidocaine, sotalol, pilsicainide, and magnesium sulfate could not control the tachycardia and she was referred to our hospital for catheter ablation. During the first session, ventricular tachycardia was easily induced and electroanatomical mapping was performed both during tachycardia and during sinus rhythm. Late diastolic potential preceding the onset of QRS wave by 45ms was detected at the infero-septal side of the apical aneurysm. 7 5s of the RF energy application at this site could terminate the tachycardia and thereafter no ventricular tachycardia was induced. But after dose-reduction or cessation of some anti-arrhythmic drugs, ventricular tachycardia was recurred and second session was performed. This time, no ventricular tachycardia was induced, then we performed isthmus transection and core isolation against the apical aneurysm. Thereafter no ventricular tachycardia was occurred in spite of dose-reduction or cessation of some anti-arrhythmic drugs. (キーワード) ventricular tachycardia / storm / old myocardial infarction / catheter ablation / aortic valve replacement (徳島大学機関リポジトリ) ● Metadata: 112988 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050001338015711104 (徳島大学機関リポジトリ: 112988, CiNii: 1050001338015711104)

国内講演発表:

1.	川端豊, 若槻哲三, 山口浩司, 福田大受, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 松浦朋美, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 : 光干渉断層法で観察される冠動脈壁微小管腔構造と局所冠動脈周囲脂肪内炎症および冠動脈プラークの関連 -未固定遺体における検討-, Beyond Angiography Japan XXV, 2021年3月.
2.	Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Hiroyuki Ito, Ueno Rie, Takayuki Ise, Todoroki Takashi, Takeshi Tobiume and Masataka Sata : Relationship between coronary intraplaque microluminal structures and local inflammation in adjacent epicardial adipose tissue - A fresh cadaveric study, 第28回日本心血管インターベンション治療学会, Sep. 2019.
3.	木田貴弘, 飛梅威, 松本和久, 坂東左知子, 松浦朋美, 添木武, 志村拓哉, 髙橋智子, 谷彰浩, 藤本裕太, 大櫛祐一郎, 數藤久美子, 髙橋智紀, 上野理絵, 門田宗之, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 : 房室ブロックの進行に伴い明らかになり，恒久的ペースメーカー植込み術後のファーフィールドR波センシングへの関与が疑われた束枝心室間副伝導路の1例, 第259回徳島医学会学術集会, 2019年8月.
4.	井口裕貴, 飛梅威, 松本和久, 坂東左知子, 松浦朋美, 添木武, 志村拓哉, 髙橋智子, 谷彰浩, 藤本裕太, 大櫛祐一郎, 數藤久美子, 髙橋智紀, 上野理絵, 門田宗之, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 : 房室ブロックの予防に順行性速伝導路と順行性遅伝導路のマッピングが有用であった順行性速伝導路の下方偏位を伴う遅速型房室結節リエントリー性頻拍の1例, 第259回徳島医学会学術集会, 2019年8月.
5.	志村拓哉, 伊勢孝之, 川端豊, 藤本裕太, 松本和久, 上野理絵, 山田なお, 伊藤浩敬, 松浦朋美, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 藤本鋭貴, 佐田政隆 : 先天性二尖弁に対するTAVIの2例, 第114回日本循環器学会中国・四国合同地方会, 2019年6月.
6.	中村昌史, 川端豊, 伊勢孝之, 藤本裕太, 原田貴文, 松本和久, 西條良仁, 上野理絵, 山田なお, 伊藤浩敬, 轟貴史, 楠瀬賢也, 飛梅威, 山口浩司, 福田大受, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 : 経食道心エコーガイド下の経皮的腫瘍生検により早期に診断し得た心臓原発血管肉腫の一例, 第114回日本循環器学会中国・四国合同地方会, 2019年6月.
7.	伊藤浩敬, 若槻哲三, 山口浩司, 福田大受, 川端豊, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 : Microluminal structures of coronary plaque and vasa vasorums affect coronary inflammation: A fresh cadaveric studys, 第83回日本循環器学会学術集会, 2019年3月.
8.	川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 福田大受, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 : Coronary intraplaque microluminal structure are associated with the quality and quantity of epicardial adipose tissue -A fresh cadaveric stury-, 第83回日本循環器学会学術集会, 2019年3月.
9.	藤本裕太, 楠瀬賢也, 西條良仁, Robert Zheng, 原田貴文, 松本和久, 上野理絵, 川端豊, 山田なお, 伊藤浩敬, 轟貴史, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 佐田政隆 : Staphylococcus による感染性内膜炎の一例, 第113回日本循環器学会四国合同地方会, 2018年12月.
10.	Robert Zheng, 伊勢孝之, 川端豊, 八木秀介, 西條良仁, 上野理絵, 坂東美佳, 伊藤浩敬, 轟貴史, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 福田大受, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 藤本鋭貴, 北川哲也, 佐田政隆 : Single coronary 合併重症ASに対してTAVIを施行し救命し得た1例, 第113回日本循環器学会四国合同地方会, 2018年12月.
11.	伊藤浩敬, 若槻哲三, 山口浩司, 福田大受, 川端豊, 伊勢孝之, 楠瀬賢也, 松浦朋美, 轟貴史, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 : 未固定遺体における冠動脈壁小管腔構造と局所心臓周囲脂肪内炎症との関連, 第66回日本心臓病学会学術集会, 2018年9月.
12.	山口浩司, 若槻哲三, 西條良仁, 上野理絵, 川端豊, 坂東美佳, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 : 第三世代薬剤溶出性ステント留置後における局所凝固反応塗装ステント長の関連性, 第66回日本心臓病学会学術集会, 2018年9月.
13.	伊藤浩敬, 添木武, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 : AVNRTアブレーション治療後に発生したJunctional Tachycardiaの1例, 第112回日本循環器学会中国・四国合同地方会, 2018年6月.
14.	轟貴史, 若槻哲三, 山口浩司, 瀬野弘光, 數藤久美子, 西條良仁, 川端豊, 上野理絵, 伊藤浩敬, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 福田大受, 山田博胤, 添木武, 佐田政隆 : EES留置3年後，術前に抗血小板剤中止しペパリン置換したにもかかわらず2枝同時ステント閉塞を起こした1例, 第112回日本循環器学会中国・四国合同地方会, 2018年6月.
15.	西尾進, 楠瀬賢也, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 伊藤浩敬, 伊勢孝之, 山口浩司, 若槻哲三, 山田博胤, 佐田政隆 : 左上肢の脱力で脳卒中センターへ搬送された急性冠症候群の1例, 超音波検査技術, Vol.43, No.3, 363, 2018年6月.
16.	Takayuki Ise, Shusuke Yagi, Yutaka Kawabata, Seno Hiromitsu, Kumiko Sutou, Yoshihito Saijoh, Rie Ueno, Hiroyuki Ito, Takafumi Todoroki, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Acute Hemodynamic Effect of Handgrip Stress in Patients with Chronic Heart Failure., 第82回日本循環器学会, Mar. 2018.
17.	Hiroyuki Ito, Kenya Kusunose, Hirotsugu Yamada, Hiromitsu Seno, Yoshihito Saijoh, Susumu Nishio, Yukina Hirata and Masataka Sata : Association of Left Ventricular Diastolic Function using American Society of Echocardiography Recommendation with Readmission in Patients with Heart Failure., 第82回日本循環器学会, Mar. 2018.
18.	Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Growth of Vasa Vasorum is Associated with Local Inflammation around Coronary Plaque in Fresh Cadavers(和訳中), 日本循環器学会学術集会抄録集, PJ007-3, Mar. 2018.
19.	Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Differential Response of Local Coagulation after Coronary Angioplasty with Paclitaxel(和訳中), 日本循環器学会学術集会抄録集, PJ022-1, Mar. 2018.
20.	八木秀介, 伊勢孝之, 川端豊, 伊藤浩敬, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 : 経カテーテル大動脈弁植込み術を施した超高齢大動脈弁狭窄症の1例, 日本老年医学会四国地方会, 2018年2月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

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特任助教 : 伊藤浩敬

研究活動

専門分野

研究テーマ

著書・論文

著書:

学術論文(審査論文):

国内講演発表:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

特任助教 : 伊藤 浩敬

研究活動

専門分野

研究テーマ

著書・論文

著書:

学術論文(審査論文):

国内講演発表:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

特任助教 : 伊藤浩敬