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徳島大学病院先端医科医療開発研究プロジェクト
徳島大学病院診療科感覚·皮膚·運動機能科整形外科
徳島大学医学部医学科感覚運動系病態医学講座運動機能外科学分野
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研究活動

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研究テーマ

著書・論文

学術論文(審査論文):

1. Yoshihiro Ishihama, Masatoshi Morimoto, Fumitake Tezuka, Kazuta Yamashita, Hiroaki Manabe, Kosuke Sugiura, Makoto Takeuchi, Yoichiro Takata, Toshinori Sakai, Toru Maeda, Akihiro Nagamachi and Koichi Sairyo :
Full-Endoscopic Trans-Kambin Triangle Lumbar Interbody Fusion: Surgical Technique and Nomenclature.,
Journal of Neurological Surgery. Part A, Central European Neurosurgery, Vol.83, No.4, 308-313, 2022.
(DOI: 10.1055/s-0041-1730970,   PubMed: 34808676)
2. Koichi Sairyo, Kazuta Yamashita, Fumitake Tezuka, Masatoshi Morimoto, Kosuke Sugiura, Makoto Takeuchi, INOKUCHI Takashi and Junzo Fujitani :
Full-endoscopic intradiscal surgery: state of the art.,
Journal of Minimally Invasive Spine Surgery and Technique, Vol.7, No.1, 84-89, 2022.
3. Masatoshi Morimoto, Kosuke Sugiura, Kousaku Higashino, Hiroaki Manabe, Fumitake Tezuka, Keizo Wada, Kazuta Yamashita, Shoichiro Takao and Koichi Sairyo :
Association of spinal anomalies with spondylolysis and spina bifida occulta,
European Spine Journal, Vol.31, No.4, 858-864, 2022.
(DOI: 10.1007/s00586-022-07139-5,   PubMed: 35237865)
4. Kitahata Kanako, Takayuki Uchida, Taniguchi Runa, Kato Ayano, Kosuke Sugiura, Iori Sakakibara, Oarada Motoko, Tomoya Fukawa, Junsoo Park, Inho Choi and Takeshi Nikawa :
Additional effects of simultaneous treatment with C14-Cblin and celastrol on the clinorotation-induced rat L6 myotube atrophy,
The Journal of Medical Investigation : JMI, Vol.69, No.1,2, 127-134, 2022.
(徳島大学機関リポジトリ: 116937,   DOI: 10.2152/jmi.69.127,   PubMed: 35466134)
5. Oarada Motoko, Yuushi Okumura, Katsuya Hirasaka, Kosuke Sugiura, Tachibana Nobuhiko, Tsurusaki Yoshinori and Takeshi Nikawa :
Dietary Sodium Nitrite Causes Similar Modifications to Splenic Inflammatory Gene Expression as a High-Fat Diet,
Journal of Nutritional Science and Vitaminology, Vol.67, No.6, 404-416, 2021.
(DOI: 10.3177/jnsv.67.404,   PubMed: 34980719)
6. Daiki Nakajima, Kazuta Yamashita, Makoto Takeuchi, Kosuke Sugiura, Masatoshi Morimoto, Fumitake Tezuka, Kiyoshi Yagi, Kazuya Kishima and Koichi Sairyo :
Full-endoscopic Spine Surgery for Discogenic Low Back Pain with High-intensity Zones and Modic Type 1 Change in a Professional Baseball Player.,
NMC Case Report Journal, Vol.8, No.1, 587-593, 2021.
(DOI: 10.2176/nmccrj.cr.2021-0038,   PubMed: 35079521)
7. Hiroaki Manabe, Toshinori Sakai, Yasuyuki Ohmichi, Kosuke Sugiura, Masatoshi Morimoto, Fumitake Tezuka, Kazuta Yamashita, Yoichiro Takata, Toru Maeda and Koichi Sairyo :
Role of growth plate (apophyseal ring fracture) in causing modic type changes in pediatric low back pain patients.,
European Spine Journal, Vol.30, No.9, 2565-2569, 2021.
(DOI: 10.1007/s00586-021-06885-2,   PubMed: 34037865)
8. Kosuke Sugiura, Masatoshi Morimoto, Kousaku Higashino, Makoto Takeuchi, Hiroaki Manabe, Shoichiro Takao, Toru Maeda and Koichi Sairyo :
Transitional vertebrae and numerical variants of the spine : prevalence and relationship to low back pain or degenerative spondylolisthesis.,
The Bone & Joint Journal, Vol.103-B, No.7, 1301-1308, 2021.
(DOI: 10.1302/0301-620X.103B7.BJJ-2020-1760.R1,   PubMed: 34192932)
9. Ayaka Hashimoto, Fumitake Tezuka, Kazuta Yamashita, Masatoshi Morimoto, Kosuke Sugiura, Makoto Takeuchi, Yoichiro Takata, Toshinori Sakai, Toru Maeda and Koichi Sairyo :
Planned Four-stage Transforaminal Full-endoscopic Lumbar Decompression under Local Anesthesia in a Patient with Severe Comorbidity.,
NMC Case Report Journal, Vol.8, No.1, 221-227, 2021.
(DOI: 10.2176/nmccrj.cr.2020-0104,   PubMed: 35079467)
10. Nobutoshi Takamatsu, Kazuta Yamashita, Kosuke Sugiura, Hiroaki Manabe, Fumitake Tezuka, Yoichiro Takata, Toshinori Sakai, Toru Maeda and Koichi Sairyo :
Successful Full Endoscopic Surgery for L5 Radiculopathy Due to L4-5 Discal Cyst and Disc Herniation in a Professional Baseball Player.,
NMC Case Report Journal, Vol.8, No.1, 189-194, 2021.
(DOI: 10.2176/nmccrj.cr.2020-0144,   PubMed: 35079462)
11. Kosuke Sugiura, Katsuya Hirasaka, Tasuku Maeda, Takayuki Uchida, Koji Kishimoto, Motoko Oarada, Siegfried Labeit, Anayt Ulla, Iori Sakakibara, Reiko Nakao, Koichi Sairyo and Takeshi Nikawa :
MuRF1 deficiency prevents age-related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice,
Journal of Orthopaedic Research, Vol.40, No.5, 1026-1038, 2021.
(徳島大学機関リポジトリ: 116581,   DOI: 10.1002/jor.25131,   PubMed: 34185335,   Elsevier: Scopus)
12. Kosuke Sugiura, Kazuta Yamashita, Hiroaki Manabe, Yoshihiro Ishihama, Fumitake Tezuka, Yoichiro Takata, Toshinori Sakai, Toru Maeda and Koichi Sairyo :
Prompt Return to Work after Bilateral Transforaminal Full-endoscopic Lateral Recess Decompression under Local Anesthesia: A Case Report.,
Journal of Neurological Surgery. Part A, Central European Neurosurgery, Vol.82, No.3, 289-293, 2021.
(DOI: 10.1055/s-0040-1712463,   PubMed: 33352609)
13. Ulla Anayt, Takayuki Uchida, Miki Yukari, Kosuke Sugiura, Higashitani Atsushi, Kobayashi Takeshi, Ohno Ayako, Reiko Nakao, Katsuya Hirasaka, Iori Sakakibara and Takeshi Nikawa :
Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes,
Archives of Biochemistry and Biophysics, Vol.704, 108873, 2021.
(徳島大学機関リポジトリ: 116344,   DOI: 10.1016/j.abb.2021.108873,   PubMed: 33848514)
14. Koichi Sairyo, Masatoshi Morimoto, Kazuta Yamashita, Fumitake Tezuka, Kosuke Sugiura, Makoto Takeuchi, Kiyoshi Yagi, Kazuya Kishima, Junzo Fujitani, Yoichiro Takata, Toshinori Sakai and Toru Maeda :
Full-endoscopic trans-Kambins triangle lumbar interbody fusion: technique and review of literature.,
Journal of Minimally Invasive Spine Surgery and Technique, Vol.6, No.Suppl1, S123-S129, 2021.
(DOI: 10.21182/JMISST.2021.00108)
15. Seiji Yamaya, Fumitake Tezuka, Kosuke Sugiura, Makoto Takeuchi, Hiroaki Manabe, Masatoshi Morimoto, Kazuta Yamashita, Yoichiro Takata, Toshinori Sakai, Toru Maeda and Koichi Sairyo :
Risk Factor for Additional Intravenous Medication during Transforaminal Full-endoscopic Lumbar Discectomy under Local Anesthesia.,
Neurologia Medico-Chirurgica, Vol.61, No.3, 236-242, 2021.
(徳島大学機関リポジトリ: 116463,   DOI: 10.2176/nmc.oa.2020-0275,   PubMed: 33504730)
16. Hiroaki Manabe, Kazuta Yamashita, Kosaku Higashino, Masatoshi Morimoto, Kosuke Sugiura, Yoshihiro Ishihama, Fumitake Tezuka, Yoichiro Takata, Toshinori Sakai and Koichi Sairyo :
Bone Formation During Correction of Vertebral Rounding Deformity in a Rat Model of Pediatric Spondylolisthesis.,
Spine, Vol.46, No.5, E294-E302, 2021.
(徳島大学機関リポジトリ: 115553,   DOI: 10.1097/BRS.0000000000003779,   PubMed: 33156272)
17. Makoto Takeuchi, Kazuta Yamashita, Ayaka Hashimoto, Nobutoshi Takamatsu, Kosuke Sugiura, Hiroaki Manabe, Fumitake Tezuka, Yoichiro Takata, Toshinori Sakai, Toru Maeda and Koichi Sairyo :
Return to the Original Work Activity Following the Full-endoscopic Lumbar Surgery under the Local Anesthesia.,
Neurologia Medico-Chirurgica, Vol.61, No.2, 144-151, 2021.
(徳島大学機関リポジトリ: 116610,   DOI: 10.2176/nmc.oa.2020-0204,   PubMed: 33390418)
18. Toshinori Sakai, Hiroaki Manabe, Tsuyoshi Goto, Kosuke Sugiura, Fumitake Tezuka, Kazuta Yamashita, Yoichiro Takata and Koichi Sairyo :
Extraosseous Signal Changes on Magnetic Resonance Imaging in Pediatric Patients with Early-Stage Lumbar Spondylolysis.,
The Journal of Medical Investigation : JMI, Vol.68, No.1.2, 136-139, 2021.
(徳島大学機関リポジトリ: 116001,   DOI: 10.2152/jmi.68.136,   PubMed: 33994458)
19. Koichi Sairyo, Toru Maeda, Kazuta Yamashita, Fumitake Tezuka, Masatoshi Morimoto, Kiyoshi Yagi, Kazuya Kishima, Kosuke Sugiura, Makoto Takeuchi, Yuji Yamada, Yoichiro Takata and Toshinori Sakai :
A new surgical strategy for the intractable chronic low back pain due to type 1 Modic change using transforaminal full-endoscopic disc cleaning (FEDC) surgery under the local anesthesia : A case report and literature review.,
The Journal of Medical Investigation : JMI, Vol.68, No.1.2, 1-5, 2021.
(徳島大学機関リポジトリ: 115977,   DOI: 10.2152/jmi.68.1,   PubMed: 33994452)
20. Ohno Ayako, Nobuo Maita, Tabata Takanori, Nagano Hikaru, Arita Kyohei, Ariyoshi Mariko, Takayuki Uchida, Reiko Nakao, Ulla Anayt, Kosuke Sugiura, Koji Kishimoto, Teshima-Kondo Shigetada, Okumura Yuushi and Takeshi Nikawa :
Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza.,
Life Science Alliance, Vol.4, No.6, e202000849, 2021.
(徳島大学機関リポジトリ: 116821,   DOI: 10.26508/LSA.202000849,   PubMed: 33820827,   Elsevier: Scopus)
21. Hiroaki Manabe, Toshinori Sakai, Kosuke Sugiura, Yoshihiro Ishihama, Fumitake Tezuka, Kazuta Yamashita, Yoichiro Takata, Toru Maeda and Koichi Sairyo :
Spontaneous Laminar Fracture during Successful Conservative Treatment of Lumbar Spondylolysis at the Adjacent Spinal Level: A Case Report.,
NMC Case Report Journal, Vol.7, No.4, 179-182, 2020.
(DOI: 10.2176/nmccrj.cr.2019-0223,   PubMed: 33062565)
22. Shun-ichi Toki, Kousaku Higashino, Hiroaki Manabe, Masatoshi Morimoto, Kosuke Sugiura, Fumitake Tezuka, Kazuta Yamashita, Yoichiro Takata, Toru Maeda, Toshinori Sakai, Natsuo Yasui and Koichi Sairyo :
Morphometric Analysis of Subaxial Cervical Spine with Myelopathy: A Comparison with the Normal Population.,
Spine Surgery and Related Research, Vol.5, No.1, 34-40, 2020.
(徳島大学機関リポジトリ: 116669,   DOI: 10.22603/ssrr.2020-0061,   PubMed: 33575493)
23. Yusaku Nakayama, Kazuta Yamashita, Kosuke Sugiura, Makoto Takeuchi, Masatoshi Morimoto, Fumitake Tezuka, Yoichiro Takata, Toshinori Sakai, Toru Maeda and Koichi Sairyo :
Surgical management of stress fracture of the contralateral pedicle in a baseball player with unilateral lumbar spondylolysis : A case report.,
The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 382-385, 2020.
(徳島大学機関リポジトリ: 115462,   DOI: 10.2152/jmi.67.382,   PubMed: 33148923)
24. Daiki Nakajima, Kazuta Yamashita, Fumitake Tezuka, Kosuke Sugiura, Yoshihiro Ishihama, Hiroaki Manabe, Yoichiro Takata, Toshinori Sakai, Toru Maeda and Koichi Sairyo :
Successful full-endoscopic decompression surgery under local anesthesia for L5 radiculopathy caused by L5-Sforaminal stenosis and L4-5 lateral recess stenosis : A case report.,
The Journal of Medical Investigation : JMI, Vol.67, No.1.2, 192-196, 2020.
(徳島大学機関リポジトリ: 114826,   DOI: 10.2152/jmi.67.192,   PubMed: 32378606)
25. Fumitake Tezuka, Toshinori Sakai, Toshihiko Nishisho, Kosuke Sugiura, Yoshihiro Ishihama, Hiroaki Manabe, Kazuta Yamashita, Yoichiro Takata, Toru Maeda and Koichi Sairyo :
Distribution of the Spinal Arteries in Adult Patients with Lumbar Spondylolysis.,
The Journal of Medical Investigation : JMI, Vol.67, No.1.2, 62-66, 2020.
(徳島大学機関リポジトリ: 114753,   DOI: 10.2152/jmi.67.62,   PubMed: 32378619)
26. Yugen Fujii, Kazuta Yamashita, Kosuke Sugiura, Yoshihiro Ishihama, Hiroaki Manabe, Fumitake Tezuka, Yoichiro Takata, Toshinori Sakai, Toru Maeda and Koichi Sairyo :
Early return to activity after minimally invasive full endoscopic decompression surgery in medical doctors.,
Journal of Spine Surgery, Vol.6, No.Suppl 1, S294-S299, 2020.
(徳島大学機関リポジトリ: 116213,   DOI: 10.21037/jss.2019.08.05,   PubMed: 32195436)
27. Shota Shigekiyo, Toshihiko Nishisho, Yoichiro Takata, Shun-ichi Toki, Kosuke Sugiura, Yoshihiro Ishihama, Hiroaki Manabe, Fumitake Tezuka, Kazuta Yamashita, Toshinori Sakai, Toru Maeda and Koichi Sairyo :
Intracanalicular Osteochondroma in the Lumbar Spine.,
NMC Case Report Journal, Vol.7, No.1, 11-15, 2020.
(DOI: 10.2176/nmccrj.cr.2019-0031,   PubMed: 31938676)
28. Hiroaki Manabe, Kosuke Sugiura, Yoshihiro Ishihama, Fumitake Tezuka, Kazuta Yamashita, Yoichiro Takata, Toshinori Sakai, Toru Maeda and Koichi Sairyo :
Imaging Features of Non-Isthmic Spondylolysis: A Case Report.,
Spine Surgery and Related Research, Vol.4, No.2, 187-189, 2019.
(徳島大学機関リポジトリ: 116255,   DOI: 10.22603/ssrr.2019-0054,   PubMed: 32405568)
29. Haruhiko Yoshinari, Fumitake Tezuka, Kazuta Yamashita, Hiroaki Manabe, Fumio Hayashi, Yoshihiro Ishihama, Kosuke Sugiura, Yoichiro Takata, Toshinori Sakai, Toru Maeda and Koichi Sairyo :
Transforaminal full-endoscopic lumbar discectomy under local anesthesia in awake and aware conditions: the inside-out and outside-in techniques.,
Current Reviews in Musculoskeletal Medicine, Vol.12, No.3, 311-317, 2019.
(DOI: 10.1007/s12178-019-09565-3,   PubMed: 31236834)

国際会議:

1. Kosuke Sugiura, Masatoshi Morimoto, Fumitake Tezuka, Kazuta Yamashita, Toshinori Sakai and Koichi Sairyo :
Early return to work after minimally invasive full endoscopic decompression surgery in medical doctors: a case series.,
The 21st Annual Meeting of the Pacific and Asian Society of Minimally Invasive Spine Surgery (PASMISS), Jul. 2021.

国内講演発表:

1. 中野 亘, 杉浦 宏祐, 内田 貴之, 榊原 伊織, 西良 浩一, 二川 健 :
廃用性萎縮筋におけるアコニターゼ活性とその保護,
第 54 回 日本栄養•食糧学会 中国•四国支部大会 第7 回日本栄養改善学会四国支部学術総会合同大会, 2021年10月.
2. 杉浦 宏祐, 二川 健, 西良 浩一 :
骨格筋の廃用による活性酸素種(ROS)の発生がアコニターゼ 活性に与える影響と筋萎縮における役割の解明,
第136回中部整形外科災害外科学会・学術集会, 2021年4月.
3. Iori Sakakibara, Kosuke Sugiura, Takayuki Uchida, Higashitani Atsushi, Kobayashi Takeshi, Sokabe Masahiro and Takeshi Nikawa :
Mechano-signals regulate mitochondria-associated membrane,
第43回日本分子生物学会年会, Dec. 2020.
4. Iori Sakakibara, Kosuke Sugiura, Takayuki Uchida, Higashitani Atsushi, Kobayashi Takeshi, Sokabe Masahiro and Nikawa Takeshi :
Mechano-signals regulate mitochondria-associated membrane,
第43回日本分子生物学会年会, Dec. 2020.
5. Iori Sakakibara, Kosuke Sugiura, Takayuki Uchida, Higashitani Atsushi, Kobayashi Takeshi, Sokabe Masahiro and Nikawa Takeshi :
Mechano-signals regulate mitochondria-associated membrane,
第43回日本分子生物学会年会, Dec. 2020.
6. 中野 亘, 三木 裕可里, 杉浦 宏祐, 榊原 伊織, 内田 貴之, 二川 健 :
ミトコンドリア小胞体接触領域 (MAM) を介した筋量調節メカニズムの解明,
第53回日本栄養食糧学会 中国・四国支部大会, 2020年10月.
7. 杉浦 宏祐, 内田 貴之, 西良 浩一, 二川 健 :
(ROS)Mitochondrial Aconitase,
35, 2020年10月.
8. 西良 浩一, 杉浦 宏祐, 内田 貴之, 二川 健 :
ミトコンドリア-小胞体接触領域(MAM)は廃用性筋委縮を制御する(一般演題 基礎:筋・腱・滑膜 ),
第93回日本整形外科学会学術総会【WEB】, 2020年5月.
9. 内田 貴之, 三木 裕加里, 杉浦 宏祐, 真板 綾子, 中尾 玲子, 平坂 勝也, 東谷 篤志, 小林 剛, 曽我部 正博, 二川 健 :
筋肉におけるミトコンドリアタンパク質Mfn2の役割,
第74回日本栄養・食糧学会大会, 2020年5月.
10. 藤岡 大樹, 内田 貴之, 杉浦 宏祐, 小林 剛, 東谷 篤志, 曽我部 正博, 二川 健 :
Unloadingによる筋萎縮におけるCa2+-ROSシグナルの変化,
第74回日本栄養・食糧学会大会, 2020年5月.
11. 加藤 彩乃, 内田 貴之, 杉浦 宏祐, 池田 泰隆, 濱田 広一郎, 二川 健 :
細胞内エネルギー代謝経路が筋繊維タイプに与える影響,
第74回日本栄養・食糧学会大会, 2020年5月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

  • メタボリックシンドロームが運動器機能に及ぼす影響と運動療法による改善機序の解明 (研究課題/領域番号: 20K09435 )
  • 廃用性筋萎縮の発生に関わるミトコンドリア・小胞体膜接触領域の機能解明 (研究課題/領域番号: 19K18501 )
  • 研究者番号(60837243)による検索