Tokushima University / Educator and Researcher Directory --- Kamada, Kumiko

Personal Web Page

https://researchmap.jp/kamakama (researchmap)

Field of Study

○	Life sciences [Surgical dentistry]

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Kumiko Kamada, Naito Kurio, Yasuhiro Mouri and Yasusei Kudo : Combination treatment with hyaluronic acid synthesis and Bcl-2 inhibitors induces senolytic elimination of oral squamous cell carcinoma cells in vitro., Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2024.
2.	Naito Kurio, Kumiko Kamada, Atsushi Uesugi, Takaaki Tsunematsu and Yasusei Kudo : 頬粘膜に発生した基底細胞腺腫の1例, 四国歯学会誌, Vol.37, No.1, 18-23, 2024.
3.	Akira Takahashi, Kumiko Kamada, Naoyuki Fukuda, Keiko Kudoh, Natsumi Takamaru, Naito Kurio, Chieko Sugawara and Youji Miyamoto : Analysis of the sublingual artery using contrast-enhanced computed tomography, Clinical Implant Dentistry and Related Research, Vol.25, No.3, 532-539, 2023. (Summary) This in vivo study aimed to clarify the position of the sublingual artery (SLA) relative to the mandibular bone and to infer the potential risk for injury during dental implant surgery. Contrast-enhanced computed tomography images of the mouth of 50 edentulous patients (100 sides) treated at Tokushima University Hospital were reviewed. Curved planar reconstructed images perpendicular to the alveolar ridge were processed and classified into molar, premolar, canine, and incisor regions. The SLA and its branches were identified, and the distance from the mandible to the SLA was measured. The SLA was located close to the mandible (<2 mm) in the molar, premolar, canine, and incisor segments in 12.0% (95% confidence interval 5.6%-18.4%), 20.6% (12.6%-28.7%), 30.5% (21.3%-39.8%), and 41.8% (28.8%-54.9%) cases, respectively. The SLA was located within ±3 mm craniocaudally to the upper wall of the mandibular canal in the molar and premolar regions in 50% of cases and within ±5 mm craniocaudally to the mylohyoid ridge in the canine and incisor regions in the other cases, with no sex or age-related differences. The vertical distance from the alveolar ridge to the SLA was influenced by sex and age owing to alveolar resorption, indicating that the alveolar ridge is not a reliable reference for predicting SLA position. As the risk of SLA injury always exist during dental implant placement and there is no way to confirm the SLA pathways in a patient, clinicians must avoid injuring the sublingual soft tissue. (Keyword) Dental Implants / Mandible / Alveolar Process / Tomography, X-Ray Computed / Cone-Beam Computed Tomography / Arteries (Link to Publication Site) ● Publication site (DOI): 10.1111/cid.13197 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36896477 ● Search Scopus @ Elsevier (PMID): 36896477 ● Search Scopus @ Elsevier (DOI): 10.1111/cid.13197 (DOI: 10.1111/cid.13197, PubMed: 36896477)
4.	Yoshiko Yamamura, 鴨居耕平, Keiko Kudoh, Naito Kurio, Kumiko Kamada, 横田美保, Atsushi Uesugi and Youji Miyamoto : A Case of Ameloblastoma Removed Using a Three-dimensional Transparent Plastic Jaw Model Which Can Visualize Internal Jawbone Structures, Journal of Oral Health and Biosciences, Vol.35, No.1, 9-13, 2022. (Keyword) ameloblastoma / three-dimensional jaw model / three-dimensional printer / visualization (Tokushima University Institutional Repository) ● Metadata: 117597 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.35.1_9 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390293412207632768 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.35.1_9 (Tokushima University Institutional Repository: 117597, DOI: 10.20738/johb.35.1_9, CiNii: 1390293412207632768)
5.	Yoshiko Yamamura, Makoto Fukui, Takaharu Kudoh, 横田美保, Kumiko Kamada, Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : ピロカルピン塩酸塩を用いた口腔リンス法の有用性と安全性の検討, Oral Care, Vol.16, No.2, 52-56, 2022. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520579212289190912 (CiNii: 1520579212289190912)
6.	Go Ohe, Yasusei Kudo, Kumiko Kamada, Yasuhiro Mouri, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : Soluble Factor from Oral Cancer Cell Lines Inhibits Interferon-γ Production by OK-432 via CD40/CD40Ligand Pathway, Cancers, Vol.13, No.13, 2021. (Tokushima University Institutional Repository) ● Metadata: 116508 (Link to Publication Site) ● Publication site (DOI): 10.3390/cancers13133301 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85108890231 (Tokushima University Institutional Repository: 116508, DOI: 10.3390/cancers13133301, Elsevier: Scopus)
7.	Akira Takahashi, Kumiko Kamada, Keiko Kudoh, Takaharu Kudoh, Natsumi Takamaru, Naito Kurio, Chieko Sugawara and Youji Miyamoto : Evaluation of anatomical references for locating the course of the posterior superior alveolar artery for dental implant surgery, International Journal of Oral and Maxillofacial Surgery, Vol.51, No.2, 257-262, 2021. (Summary) This retrospective cohort study aimed to identify the best anatomical reference for predicting the posterior superior alveolar artery (PSAA) location. Computed tomographic images of 90 maxillary sinuses were evaluated. We studied five references, including the alveolar crest, maxillary sinus floor, zygomatoalveolar crest, hard palate and soft palate, and measured the distances between them and the PSAA. Variations in the distance were evaluated by the standard deviation and coefficient of variation (CV). The zygomatoalveolar crest was an unstable reference, owing to its high standard deviation and CV. The smallest CV was for the distance between the alveolar crest and PSAA, although the distance was smaller in edentulous jaws than dentulous jaws. The distance between the sinus floor and PSAA was larger in male and edentulous patients. The PSAA was detected in 40.0%, 44.4%, 54.4% and 56.7% of the sinus walls at the first and second premolar and the first and second molar positions, respectively. At these tooth positions, the respective heights above the hard palate were 11.2 ± 4.9, 8.2 ± 4.9, 6.2 ± 2.8 and 8.1 ± 2.9 mm. The hard palate was the most stable reference for predicting the location of the PSAA, irrespective of sex, age and dentition. (Keyword) Arteries / Cone-Beam Computed Tomography / Dental Implants / Humans / Male / Maxillary Sinus / Retrospective Studies / Sinus Floor Augmentation (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ijom.2021.05.013 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34083086 ● Summary page in Scopus @ Elsevier: 2-s2.0-85107155071 (DOI: 10.1016/j.ijom.2021.05.013, PubMed: 34083086, Elsevier: Scopus)
8.	Yoshiko Yamamura, Takamitsu Mano, Kumiko Kamada, 横田美保, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : A clinical study on malignant lymphomas arising in the oral region, Journal of Japan Society for Oral Tumors, Vol.33, No.2, 35-60, 2021. (Summary) We examined the clinical characteristics of 18 cases of malignant lymphomas arising in the oral region which were diagnosed at our department during the 11 years from 2008 to 2018. The patients consisted of 10 males and 8 females whose mean age was 70.2 years. The primary site was the upper gingiva in 10 cases (55.6%), and the initial symptoms were tumor mass and swelling in 15 cases (83.3%). Only 7 cases (38.9%) were clinically diagnosed as malignant lymphoma at first visit, but the other 11 cases were difficult to diagnose correctly. The various clinical symptoms such as mass formation and ulcer made differential diagnosis difficult, and a definitive diagnosis could not be obtained by only a single biopsy. Therefore, we examined whether blood test results might be used as an indicator of the diagnosis or not. Our results showed that LDH in 8 of 17 cases (47.1%) and sIL-2R in 11 of 16 cases (68.8%) were high values. Furthermore, we examined whether lymphocyte-monocyte ratio (LMR) helped the diagnosis or not. Thirteen of 17 cases (76.5%) showed a low value of LMR. There was a significant difference in LMR compared to non-malignant lymphoma patients. LMR in the blood tests was also considered to be a useful marker for the diagnosis. (Keyword) malignant lymphoma / clinical study / oral region / lymphocyte-monocyte ratio (Tokushima University Institutional Repository) ● Metadata: 116069 (Link to Publication Site) ● Publication site (DOI): 10.5843/jsot.33.35 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390851398293094784 ● Search Scopus @ Elsevier (DOI): 10.5843/jsot.33.35 (Tokushima University Institutional Repository: 116069, DOI: 10.5843/jsot.33.35, CiNii: 1390851398293094784)
9.	Keiko Kudoh, Kazumi Takaishi, Takaharu Kudoh, Natsumi Takamaru, Kumiko Kamada and Youji Miyamoto : Inferior alveolar nerve paresthesia caused by the extrusion of calcium hydroxide-based paste into themandibular canal: A case report., Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Vol.32, No.5, 366-369, 2020. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ajoms.2020.05.005 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajoms.2020.05.005 (DOI: 10.1016/j.ajoms.2020.05.005)
10.	Naito Kurio, Kumiko Kamada, Takumi Kitagawa, Yasusei Kudo, Naozumi Ishimaru and Youji Miyamoto : A case of microcystic adnexal carcinoma arising in the upper gingiva, Japanese Journal of Oral & Maxillofacial Surgery, Vol.66, No.9, 455-459, 2020. (Summary) <p>Microcystic adnexal carcinoma (MAC) is a rare malignant tumor of skin appendages. MAC grows slowly, but is locally aggressive. The metastatic potential is low, but the recurrence rates are very high owing to insufficient dissection. The most common location of MAC is the skin of the midface of middle-aged adults. There has been no report about MAC arising in the gingiva. We report here an extremely rare case of MAC of the upper gingiva in a 53-year-old woman. She presented to our hospital with a 6-year history of a gradually increasing gingival mass. Intraoral examination revealed a smooth, poorly circumscribed mass with white granules resembling Fordyce spots on her upper gingiva. There was no bone destruction or regional lymph node swelling. The histopathological diagnosis was a tumor of skin appendages. Tumor resection was performed. Postoperative pathological examination revealed that the tumor differentiated into hair follicles and the sweat-gland-like structures and deeply infiltrated into muscle, perineural spaces, and bone. Since the surgical margins were positive, additional resection was performed after preoperative mapping biopsy. Finally, the tumor was completely excised. No tumor recurrence or metastasis have been observed over 1 year.</p> (Link to Publication Site) ● Publication site (DOI): 10.5794/jjoms.66.455 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1391975276372989696 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.66.455 (DOI: 10.5794/jjoms.66.455, CiNii: 1391975276372989696)
11.	Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Naito Kurio, Keiko Kudoh, Tsuru Kanji, Ishikawa Kunio and Youji Miyamoto : Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects, Journal of Biomedical Materials Research. Part A, Vol.108, No.3, 709-721, 2020. (Summary) Carbonate apatite (CO Ap) granules are known to show good osteoconductivity and replaced to new bone. On the other hand, it is well known that a porous structure allows bone tissue to penetrate its pores, and the optimal pore size for bone ingrowth is dependent on the composition and structure of the scaffold material. Therefore, the aim of this study was to fabricate various porous CO Ap granules through a two-step dissolution-precipitation reaction using CaSO as a precursor and 30-, 50-, 120-, and 205-μm diameter microfibers as porogen and to find the optimal pore size of CO Ap. Porous CO Ap granules were successfully fabricated with pore size 8.2-18.7% smaller than the size of the original fiber porogen. Two weeks after the reconstruction of rabbit calvarial bone defects using porous CO Ap granules, the largest amount of mature bone was seen to be formed inside the pores of CO Ap (120) [porous CO Ap granules made using 120-μm microfiber] followed by CO Ap (50) and CO Ap (30). At 4 and 8 weeks, no statistically significant difference was observed based on the pore size, even though largest amount of mature bone was formed in case of CO Ap (120). It is concluded, therefore, that the optimal pore size of the CO Ap is that of CO Ap (120), which is 85 μm. (Tokushima University Institutional Repository) ● Metadata: 114682 (Link to Publication Site) ● Publication site (DOI): 10.1002/jbm.a.36850 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31756282 ● Summary page in Scopus @ Elsevier: 2-s2.0-85076129237 (Tokushima University Institutional Repository: 114682, DOI: 10.1002/jbm.a.36850, PubMed: 31756282, Elsevier: Scopus)
12.	Keiko Kudoh, Kumiko Kamada, Natsumi Takamaru, Yoshiko Yamamura, Go Ohe, Takaharu Kudoh, Akira Takahashi, Tetsuya Tamatani, Kenji Fujisawa and Youji Miyamoto : 徳島県における口腔がん検診の現状, 日本歯科人間ドック学会誌, Vol.12, No.1, 21-25, 2017.

Proceeding of International Conference:

1.	Takamitsu Mano, Naoyuki Fukuda, Kazuya Akita, Kumiko Kamada, Naito Kurio and Youji Miyamoto : Comparative Study On Tissue Response To Low Crystalline Carbonate Apatite, NEOBONE® And Bio-Oss® In A Dog Model, 24th Congress of the European Association for Cranio Maxillo Facial Surgery, Sep. 2018.

Proceeding of Domestic Conference:

1.	Naito Kurio, Kumiko Kamada, Naoyuki Fukuda and Natsumi Takamaru : 顎変形症の術後管理中に解離性てんかん発作を発症した一例, 第34回日本顎変形症学会総会・学術大会, Jun. 2024.
2.	赤井享輔, Kumiko Kamada, Atsushi Uesugi and Naito Kurio : 咀嚼困難を契機に診断された重症筋無力症の一例, 第53回口腔外科学会中国四国支部学術集会, Jun. 2024.
3.	Susumu Abe, Naito Kurio, Yoritoki Tomotake, Kumiko Kamada, Toshinori Okawa, Eiji Yamauchi, Youji Miyamoto and Tetsuo Ichikawa : A case of implant-supported overdenture for severe bone defect of the mandible and vascularized fibular graft by carcinoma of the lower gingiva, 日本口腔インプラント学会誌第43回関東・甲信越支部学術大会, 105, Feb. 2024.
4.	Naito Kurio, Kumiko Kamada, Atsushi Uesugi, 横田美保, 赤井亨輔, Yoshiko Yamamura, Akira Takahashi and Youji Miyamoto : ヒアルロン酸阻害薬による口腔扁平上皮癌細胞の老化誘導とsenolytic therapy, 第68回日本口腔外科学会総会・学術大会, Nov. 2023.
5.	Atsushi Uesugi, Naito Kurio, 赤井亨輔, 横田美保, Kumiko Kamada and 宮本洋二 : A case of recurrent ameloblastoma in the mandibular ramus resected using a high perimandibular approach, 第52回日本口腔外科学会中国四国支部学術集会, Jul. 2023.
6.	Keiichiro Watanabe, Emiko Nakaue, Kumiko Kamada, Natsumi Takamaru, Naito Kurio and Eiji Tanaka : 3DシミュレーションとCAD/CAMスプリントを用いて上下顎移動術を施行した顎偏位を伴う骨格性下顎前突の1例, The Japanese Journal of Jaw Deformities, Vol.33, No.2, 174, May 2023. (Keyword) 顎前突症(合併症, 外科的療法, 診断) / スプリント, 不正咬合-アングルIII級(合併症, 外科的療法, 診断) / コンピュータ支援設計, コンピュータシミュレーション / 三次元イメージング, 顎矯正手術 / ヒト; 成人(19∼44); 女; 歯学
7.	Yoshiko Yamamura, Yasuhiro Mouri, Kumiko Kamada, Naito Kurio, Keiko Kudoh, Yasusei Kudo and Youji Miyamoto : 唾液腺の発達・再生におけるNrepの役割, 第77回NPO法人日本口腔科学会学術集会, May 2023.
8.	Naoyuki Fukuda, Kazuya Akita, Kumiko Kamada, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : 炭酸アパタイト製骨補填材を用いた上顎洞底挙上術後の長期予後について, 公益社団法人日本口腔インプラント学会第42回中国・四国支部学術大会, Nov. 2022.
9.	Atsushi Uesugi, Naito Kurio, Kumiko Kamada, 横田美保, Keiko Kudoh and Youji Miyamoto : 機能的スクリーニングによる新規の口腔癌関連癌抑制microRNAの検索, 第67回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2022.
10.	Yoshiko Yamamura, Naito Kurio, Kumiko Kamada, Takaharu Kudoh, Akira Takahashi, Keiko Kudoh and Youji Miyamoto : チタン製インプラント体のオッセオインテグレーション獲得に関与するmiRNAの検索, 第67回日本口腔外科学会総会・学術大会, Nov. 2022.
11.	Kumiko Kamada, Naito Kurio, Atsushi Uesugi, Yoshiko Yamamura and Youji Miyamoto : 口腔扁平上皮癌細胞株に対するヒアルロン酸合成阻害の抗腫瘍効果, 第67回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2022.
12.	横田美保, Naito Kurio, Kumiko Kamada, Atsushi Uesugi and Youji Miyamoto : 翼突鉤切除を行ったPterygoid hamulus bursitisの1例, 第69回(公社)日本口腔科学会中国四国支部学術集会, Oct. 2022.
13.	Kumiko Kamada, Naito Kurio, Atsushi Uesugi, 横田美保, Kazuya Akita, Naoyuki Fukuda, Yoshiko Yamamura, Takaharu Kudoh, Natsumi Takamaru, Keiko Kudoh, Akira Takahashi and Youji Miyamoto : 歯性感染症により発症した側頭部ガス壊疽の1例, 第50回(公社)日本口腔外科学会中国四国支部学術集会, Jan. 2022.
14.	Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Atsushi Uesugi, Yoshiko Yamamura, Takaharu Kudoh, Natsumi Takamaru, Keiko Kudoh, Naito Kurio, Akira Takahashi and Youji Miyamoto : 炭酸アパタイト顆粒(サイトランスグラニュール)を用いて歯槽骨造成を行った2例, 第68 回NPO 法人日本口腔科学会中国・四国地方部会, Nov. 2021.
15.	Yoshiko Yamamura, Yasusei Kudo, Kumiko Kamada, Naito Kurio, 横田美保, Atsushi Uesugi and Youji Miyamoto : 唾液腺の発達・再生におけるΔNp63-Nrep axisの役割, 第66回日本口腔外科学会総会・学術大会, Nov. 2021.
16.	Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Takaharu Kudoh, 椋本修平, Natsumi Takamaru, Naito Kurio, Kumiko Kamada and Youji Miyamoto : 炭酸アパタイト顆粒と魚うろこコラーゲンの複合化による新規骨補填材の開発, 第66回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2021.
17.	Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Go Ohe, Takamitsu Mano, 石川邦夫, 都留寛治 and Youji Miyamoto : マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の開発とウサギ頭蓋骨における組織学的評価, 第75回日本口腔科学会学術集会, May 2021.
18.	Kumiko Kamada, Naito Kurio, Naoyuki Fukuda, 横田美保, Kazuya Akita, Atsushi Uesugi, Yoshiko Yamamura, Takaharu Kudoh, Akira Takahashi and 宮本洋二 : 口腔癌術後に多発肺結節を認めた敗血症性肺塞栓症の一例, 第49回(公社)日本口腔外科学会中国四国支部学術集会, Feb. 2021.
19.	Natsumi Takamaru, Naoyuki Fukuda, Kumiko Kamada, Kazuya Akita, Go Ohe, Naito Kurio and Youji Miyamoto : 早期口腔扁平上皮癌におけるPD-L1とZEB-1の発現と予後との関連について, 第65回日本口腔外科学会総会・学術大会, Nov. 2020.
20.	Naito Kurio, Kumiko Kamada, Yoshiko Yamamura, Keiko Kudoh and Youji Miyamoto : 潰瘍性大腸炎の合併症と考えれらた難治性口腔潰瘍の一例, 第73回日本口腔科学会学術集会, Apr. 2019.
21.	Kumiko Kamada, Keiko Kudoh, Tetsuya Tamatani, Natsumi Takamaru, Yoshiko Yamamura, Go Ohe, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 舌に発生したメトトレキサート関連リンパ増殖性疾患の1例, 第45回(公社)日本口腔外科学会中国四国支部学術大会, May 2016.
22.	Go Ohe, Kumiko Kamada, Natsumi Takamaru, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 頬粘膜に発生した基底細胞腺腫の1例, 第45回(公社)日本口腔外科学会中国四国支部学術大会, May 2016.
23.	Keiko Kudoh, Tetsuya Tamatani, Natsumi Takamaru, 木内誠, Kumiko Kamada, Hirokazu Nagai, Kazumi Takaishi and Youji Miyamoto : 水酸化カルシウム系根管充填材料の根尖外溢出により下歯槽神経麻痺が生じた1例, 第62回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2014.
24.	Masako Fujioka-Kobayashi, Hirokazu Nagai, 原香苗, Kumiko Kamada, Takaharu Kudoh, Kenji Fujisawa and Youji Miyamoto : 炭酸アパタイト被膜炭酸カルシウムを用いた新規骨置換材料による骨再生の試み, 第59回(公社)日本口腔外科学会総会・学術大会, Oct. 2014.
25.	Kumiko Kamada, Go Ohe, Takaharu Kudoh, Hirokazu Nagai and Youji Miyamoto : 舌根部に発生した骨性分離腫の1例, 第68回NPO法人日本口腔科学会学術集会, May 2014.
26.	Kumiko Kamada, Go Ohe, Kenji Fujisawa, Daisuke Uchida and Youji Miyamoto : 吸収性メッシュと骨髄海綿骨細片骨移植で再建した上顎前歯部にインプラント治療を行った1例, 第17回日本顎顔面インプラント学会学術大会, Nov. 2013.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Development of Combined Bone and Cartilage Regenerative Medicine Using Adipose-Derived Pluripotent Cells and Porous Carbonate Apatite (Project/Area Number: 19K19199 )
Search by Researcher Number (60836469)

Assistant Professor : Kamada, Kumiko

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)