Tokushima University / Educator and Researcher Directory --- Uesugi, Atsushi

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Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 歯学域 ⟩ Oral Science ⟩ Clinical Dentistry ⟩ Department of Oral Surgery ⟩
Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Oral and Maxillofacial Surgery ⟩ Oral and Maxilofacial Surgery ⟩
Tokushima University ⟩ Faculty of Dentistry ⟩ Course in Dentistry ⟩ Clinical Dentistry for Oral Health and Surgery ⟩ Oral Surgery ⟩

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Research

Personal Web Page

https://researchmap.jp/7000028986 (researchmap)

Field of Study

○	Molecular and Cellular Biology
○	Molecular Cell Biology

Subject of Study

○	Development of oral cancer treatment with novel microRNAs independently selected from functional screening (cancer, gene, cell, genome)
○	がん抑制型microRNAの経皮投与による新規治療法の開発 (gene, cancer)

Book / Paper

Academic Paper (Judged Full Paper):

1.	Atsushi Uesugi, Fumihiko Tsushima, Youji Miyamoto and Hiroyuki Harada : Pollen food allergy syndrome caused by Japanese radish: A case report, Indian Journal of Dermatology, Vol.68, No.1, 123, 2023. (Summary) Pollen food allergy syndrome (PFAS) is a food allergy that manifests as hypersensitivity symptoms of the oropharyngeal mucosa on ingesting specific foods, and findings resemble herpetic gingivostomatitis. Few reports of PFAS caused by consuming radishes are found in the literature. A 31-year-old man presented to our department with stomatitis and pharyngeal pain. He had no history of allergies. Herpetic gingivostomatitis was suspected. He was admitted to the emergency room a few days later complaining of oral and epigastric pain. Symptoms were similar to those reported previously. He reported frequently consuming raw Japanese radish ( L.) which gave rise to his symptoms. Japanese radish was suspected as the allergen. The skin-prick test confirmed the diagnosis of PFAS. PFAS can be diagnosed easily once the food-causing symptoms are identified. Upon encountering widespread erosion in the oral cavity, it is essential to consider PFAS as the possible cause. (Keyword) herpetic gingivostomatitis / Japanese radish / pollen food allergy syndrome / Raphans sativus L. / skin prick test (Link to Publication Site) ● Publication site (DOI): 10.4103/ijd.ijd_405_22 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37151264 ● Search Scopus @ Elsevier (PMID): 37151264 ● Search Scopus @ Elsevier (DOI): 10.4103/ijd.ijd_405_22 (DOI: 10.4103/ijd.ijd_405_22, PubMed: 37151264)
2.	Yoshiko Yamamura, 鴨居耕平, Keiko Kudoh, Naito Kurio, Kumiko Kamada, 横田美保, Atsushi Uesugi and Youji Miyamoto : A Case of Ameloblastoma Removed Using a Three-dimensional Transparent Plastic Jaw Model Which Can Visualize Internal Jawbone Structures, Journal of Oral Health and Biosciences, Vol.35, No.1, 9-13, 2022. (Keyword) ameloblastoma / three-dimensional jaw model / three-dimensional printer / visualization (Tokushima University Institutional Repository) ● Metadata: 117597 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.35.1_9 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390293412207632768 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.35.1_9 (Tokushima University Institutional Repository: 117597, DOI: 10.20738/johb.35.1_9, CiNii: 1390293412207632768)
3.	Fumihiko Tsushima, Jinkyo Sakurai, Atsushi Uesugi, Yu Oikawa, Toshimitu Ohsako, Yumi Mochizuki, Hideaki Hirai, Kou Kayamori and Hiroyuki Harada : Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients, BMC Oral Health, Vol.21, No.1, 298, 2021. (Summary) Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear. We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions, oral lichenoid drug reactions and oral lichenoid lesions of graft-versus-host disease were excluded. The study population included 123 men and 442 women aged 21-93 years (mean ± standard deviation, 60.5 ± 11.8). The 565 patients were followed up for a duration of 55.9 ± 45.3 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type. Our results suggested that OLP was associated with a low risk of malignant transformation. We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia and OLLs to enable early detection of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary. (Keyword) cancer / Oral mucosal disease (Tokushima University Institutional Repository) ● Metadata: 117417 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12903-021-01652-7 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34112142 ● Search Scopus @ Elsevier (PMID): 34112142 ● Search Scopus @ Elsevier (DOI): 10.1186/s12903-021-01652-7 (Tokushima University Institutional Repository: 117417, DOI: 10.1186/s12903-021-01652-7, PubMed: 34112142)

Academic Paper (Unrefereed Paper):

1.	Atsushi Uesugi, Fumihiko Tsushima, Makoto Kodama, Takeshi Kuroshima, Jinkyo Sakurai and Hiroyuki Harada : Oral granuloma in a pediatric patient with chronic graft-versus-host disease: a case report, World Journal of Clinical Cases, Vol.8, No.22, 5663-5669, 2020. (Summary) Oral mucositis is often observed with graft-versus-host disease (GVHD); however, the occurrence of oral granuloma is rare. The rapid increase in granulomatous lesions should be distinguished from malignant tumors in patients with GVHD because malignant diseases can develop in those patients. This case is the youngest pediatric patient with granuloma associated with GVHD. The patient was a 1-year and 5-mo-old girl who presented to our department for the management of oral nodules. At the age of 5 mo, she was diagnosed with primary immunodeficiency disease, cord blood transplant was performed at 11 mo and bone marrow transplant at 1 year of age. After transplantation, GVHD and oral mucositis developed, and tacrolimus was administered. Interestingly, nodules appeared on the lower lip and buccal mucosa, which spontaneously disappeared. Then, a new nodule appeared on the left lateral border of the tongue. Resection was performed and the histopathological diagnosis was granuloma. The origin of these nodules were considered to be the fibroblasts activated under inflammation caused by GVHD because the calcineurin inhibitor tacrolimus acted on their proliferation. It is very important to distinguish oral granulomatous lesions from malignancies if GVHD is present at the base and if immunosuppressive agents and steroids are being administered. (Tokushima University Institutional Repository) ● Metadata: 116161 (Link to Publication Site) ● Publication site (DOI): 10.12998/wjcc.v8.i22.5663 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33344558 ● Search Scopus @ Elsevier (PMID): 33344558 ● Search Scopus @ Elsevier (DOI): 10.12998/wjcc.v8.i22.5663 (Tokushima University Institutional Repository: 116161, DOI: 10.12998/wjcc.v8.i22.5663, PubMed: 33344558)

Proceeding of Domestic Conference:

1.	赤井享輔, Kumiko Kamada, Atsushi Uesugi and Naito Kurio : 咀嚼困難を契機に診断された重症筋無力症の一例, 第53回口腔外科学会中国四国支部学術集会, Jun. 2024.
2.	Naito Kurio, Kumiko Kamada, Atsushi Uesugi, 横田美保, 赤井亨輔, Yoshiko Yamamura, Akira Takahashi and Youji Miyamoto : ヒアルロン酸阻害薬による口腔扁平上皮癌細胞の老化誘導とsenolytic therapy, 第68回日本口腔外科学会総会・学術大会, Nov. 2023.
3.	Atsushi Uesugi, Naito Kurio, 赤井亨輔, 横田美保, Kumiko Kamada and 宮本洋二 : A case of recurrent ameloblastoma in the mandibular ramus resected using a high perimandibular approach, 第52回日本口腔外科学会中国四国支部学術集会, Jul. 2023.
4.	Atsushi Uesugi, Naito Kurio, Kumiko Kamada, 横田美保, Keiko Kudoh and Youji Miyamoto : 機能的スクリーニングによる新規の口腔癌関連癌抑制microRNAの検索, 第67回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2022.
5.	Kumiko Kamada, Naito Kurio, Atsushi Uesugi, Yoshiko Yamamura and Youji Miyamoto : 口腔扁平上皮癌細胞株に対するヒアルロン酸合成阻害の抗腫瘍効果, 第67回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2022.
6.	横田美保, Naito Kurio, Kumiko Kamada, Atsushi Uesugi and Youji Miyamoto : 翼突鉤切除を行ったPterygoid hamulus bursitisの1例, 第69回(公社)日本口腔科学会中国四国支部学術集会, Oct. 2022.
7.	Kumiko Kamada, Naito Kurio, Atsushi Uesugi, 横田美保, Kazuya Akita, Naoyuki Fukuda, Yoshiko Yamamura, Takaharu Kudoh, Natsumi Takamaru, Keiko Kudoh, Akira Takahashi and Youji Miyamoto : 歯性感染症により発症した側頭部ガス壊疽の1例, 第50回(公社)日本口腔外科学会中国四国支部学術集会, Jan. 2022.
8.	Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Atsushi Uesugi, Yoshiko Yamamura, Takaharu Kudoh, Natsumi Takamaru, Keiko Kudoh, Naito Kurio, Akira Takahashi and Youji Miyamoto : 炭酸アパタイト顆粒(サイトランスグラニュール)を用いて歯槽骨造成を行った2例, 第68 回NPO 法人日本口腔科学会中国・四国地方部会, Nov. 2021.
9.	Yoshiko Yamamura, Yasusei Kudo, Kumiko Kamada, Naito Kurio, 横田美保, Atsushi Uesugi and Youji Miyamoto : 唾液腺の発達・再生におけるΔNp63-Nrep axisの役割, 第66回日本口腔外科学会総会・学術大会, Nov. 2021.
10.	Kumiko Kamada, Naito Kurio, Naoyuki Fukuda, 横田美保, Kazuya Akita, Atsushi Uesugi, Yoshiko Yamamura, Takaharu Kudoh, Akira Takahashi and 宮本洋二 : 口腔癌術後に多発肺結節を認めた敗血症性肺塞栓症の一例, 第49回(公社)日本口腔外科学会中国四国支部学術集会, Feb. 2021.
11.	Atsushi Uesugi, 津島文彦, Youji Miyamoto and 原田浩之 : 大根おろしによる口腔アレルギー症候群の一例, 第33回日本口腔診断学会，第30回日本口腔内科学会, Oct. 2020.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

がん抑制型microRNAの経皮投与による新規治療法の開発 (Project/Area Number: 24K13158 )
頸部リンパ節転移の超早期診断の挑戦-転移可視化モデルの樹立と超音波診断法の構築 (Project/Area Number: 24K13133 )
ヒアルロン酸合成阻害剤による口腔癌のBcl2発現増強を標的とした老化細胞除去療法 (Project/Area Number: 24K13090 )
機能的スクリーニングから独自に選出した新規microRNAによる口腔癌治療の開発 (Project/Area Number: 21K10140 )
Functional screening of tumor suppressive microRNA and application to nucleic acid medicine (Project/Area Number: 25861918 )
Search by Researcher Number (20637061)