徳島大学 / 教育研究者総覧 --- 上杉篤史

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徳島大学 ⟩ 大学院医歯薬学研究部 ⟩ 歯学域 ⟩ 口腔科学部門 ⟩ 臨床歯学系 ⟩ 口腔外科学 ⟩
徳島大学 ⟩ 病院 ⟩ 診療科 ⟩ 歯科口腔外科 ⟩ 口腔外科 ⟩
徳島大学 ⟩ 歯学部 ⟩ 歯学科 ⟩ 口腔疾患系臨床歯学講座 ⟩ 口腔外科学 ⟩

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研究活動

個人のホームページ

https://researchmap.jp/7000028986 (researchmap)

専門分野

○	分子細胞生物学 (Molecular and Cellular Biology)

研究テーマ

○	機能的スクリーニングから独自に選出した新規microRNAによる口腔癌治療の開発 (癌 (cancer), 遺伝子 (gene), 細胞 (cell), ゲノム (genome))

著書・論文

学術論文(審査論文):

1.	Atsushi Uesugi, Fumihiko Tsushima, Youji Miyamoto and Hiroyuki Harada : Pollen food allergy syndrome caused by Japanese radish: A case report, Indian Journal of Dermatology, Vol.68, No.1, 123, 2023. (要約) Pollen food allergy syndrome (PFAS) is a food allergy that manifests as hypersensitivity symptoms of the oropharyngeal mucosa on ingesting specific foods, and findings resemble herpetic gingivostomatitis. Few reports of PFAS caused by consuming radishes are found in the literature. A 31-year-old man presented to our department with stomatitis and pharyngeal pain. He had no history of allergies. Herpetic gingivostomatitis was suspected. He was admitted to the emergency room a few days later complaining of oral and epigastric pain. Symptoms were similar to those reported previously. He reported frequently consuming raw Japanese radish ( L.) which gave rise to his symptoms. Japanese radish was suspected as the allergen. The skin-prick test confirmed the diagnosis of PFAS. PFAS can be diagnosed easily once the food-causing symptoms are identified. Upon encountering widespread erosion in the oral cavity, it is essential to consider PFAS as the possible cause. (キーワード) herpetic gingivostomatitis / Japanese radish / pollen food allergy syndrome / Raphans sativus L. / skin prick test (出版サイトへのリンク) ● Publication site (DOI): 10.4103/ijd.ijd_405_22 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37151264 ● Search Scopus @ Elsevier (PMID): 37151264 ● Search Scopus @ Elsevier (DOI): 10.4103/ijd.ijd_405_22 (DOI: 10.4103/ijd.ijd_405_22, PubMed: 37151264)
2.	山村佳子, 鴨居耕平, 工藤景子, 栗尾奈愛, 鎌田久美子, 横田美保, 上杉篤史, 宮本洋二 : A Case of Ameloblastoma Removed Using a Three-dimensional Transparent Plastic Jaw Model Which Can Visualize Internal Jawbone Structures, Journal of Oral Health and Biosciences, Vol.35, No.1, 9-13, 2022年. (キーワード) ameloblastoma / three-dimensional jaw model / three-dimensional printer / visualization (徳島大学機関リポジトリ) ● Metadata: 117597 (出版サイトへのリンク) ● Publication site (DOI): 10.20738/johb.35.1_9 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390293412207632768 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.35.1_9 (徳島大学機関リポジトリ: 117597, DOI: 10.20738/johb.35.1_9, CiNii: 1390293412207632768)
3.	Fumihiko Tsushima, Jinkyo Sakurai, Atsushi Uesugi, Yu Oikawa, Toshimitu Ohsako, Yumi Mochizuki, Hideaki Hirai, Kou Kayamori and Hiroyuki Harada : Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients, BMC Oral Health, Vol.21, No.1, 298, 2021. (要約) Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear. We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions, oral lichenoid drug reactions and oral lichenoid lesions of graft-versus-host disease were excluded. The study population included 123 men and 442 women aged 21-93 years (mean ± standard deviation, 60.5 ± 11.8). The 565 patients were followed up for a duration of 55.9 ± 45.3 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type. Our results suggested that OLP was associated with a low risk of malignant transformation. We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia and OLLs to enable early detection of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary. (キーワード) 癌 (cancer) / 口腔粘膜疾患 (徳島大学機関リポジトリ) ● Metadata: 117417 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12903-021-01652-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34112142 ● Search Scopus @ Elsevier (PMID): 34112142 ● Search Scopus @ Elsevier (DOI): 10.1186/s12903-021-01652-7 (徳島大学機関リポジトリ: 117417, DOI: 10.1186/s12903-021-01652-7, PubMed: 34112142)

学術論文(紀要・その他):

1.	Atsushi Uesugi, Fumihiko Tsushima, Makoto Kodama, Takeshi Kuroshima, Jinkyo Sakurai and Hiroyuki Harada : Oral granuloma in a pediatric patient with chronic graft-versus-host disease: a case report, World Journal of Clinical Cases, Vol.8, No.22, 5663-5669, 2020. (要約) Oral mucositis is often observed with graft-versus-host disease (GVHD); however, the occurrence of oral granuloma is rare. The rapid increase in granulomatous lesions should be distinguished from malignant tumors in patients with GVHD because malignant diseases can develop in those patients. This case is the youngest pediatric patient with granuloma associated with GVHD. The patient was a 1-year and 5-mo-old girl who presented to our department for the management of oral nodules. At the age of 5 mo, she was diagnosed with primary immunodeficiency disease, cord blood transplant was performed at 11 mo and bone marrow transplant at 1 year of age. After transplantation, GVHD and oral mucositis developed, and tacrolimus was administered. Interestingly, nodules appeared on the lower lip and buccal mucosa, which spontaneously disappeared. Then, a new nodule appeared on the left lateral border of the tongue. Resection was performed and the histopathological diagnosis was granuloma. The origin of these nodules were considered to be the fibroblasts activated under inflammation caused by GVHD because the calcineurin inhibitor tacrolimus acted on their proliferation. It is very important to distinguish oral granulomatous lesions from malignancies if GVHD is present at the base and if immunosuppressive agents and steroids are being administered. (徳島大学機関リポジトリ) ● Metadata: 116161 (出版サイトへのリンク) ● Publication site (DOI): 10.12998/wjcc.v8.i22.5663 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33344558 ● Search Scopus @ Elsevier (PMID): 33344558 ● Search Scopus @ Elsevier (DOI): 10.12998/wjcc.v8.i22.5663 (徳島大学機関リポジトリ: 116161, DOI: 10.12998/wjcc.v8.i22.5663, PubMed: 33344558)

国内講演発表:

1.	栗尾奈愛, 鎌田久美子, 上杉篤史, 横田美保, 赤井亨輔, 山村佳子, 高橋章, 宮本洋二 : ヒアルロン酸阻害薬による口腔扁平上皮癌細胞の老化誘導とsenolytic therapy, 第68回日本口腔外科学会総会・学術大会, 2023年11月.
2.	上杉篤史, 栗尾奈愛, 鎌田久美子, 横田美保, 工藤景子, 宮本洋二 : 機能的スクリーニングによる新規の口腔癌関連癌抑制microRNAの検索, 第67回公益社団法人日本口腔外科学会総会・学術大会, 2022年11月.
3.	鎌田久美子, 栗尾奈愛, 上杉篤史, 山村佳子, 宮本洋二 : 口腔扁平上皮癌細胞株に対するヒアルロン酸合成阻害の抗腫瘍効果, 第67回公益社団法人日本口腔外科学会総会・学術大会, 2022年11月.
4.	横田美保, 栗尾奈愛, 鎌田久美子, 上杉篤史, 宮本洋二 : 翼突鉤切除を行ったPterygoid hamulus bursitisの1例, 第69回(公社)日本口腔科学会中国四国支部学術集会, 2022年10月.
5.	鎌田久美子, 栗尾奈愛, 上杉篤史, 横田美保, 秋田和也, 福田直志, 山村佳子, 工藤隆治, 髙丸菜都美, 工藤景子, 高橋章, 宮本洋二 : 歯性感染症により発症した側頭部ガス壊疽の1例, 第50回(公社)日本口腔外科学会中国四国支部学術集会, 2022年1月.
6.	秋田和也, 福田直志, 鎌田久美子, 上杉篤史, 山村佳子, 工藤隆治, 髙丸菜都美, 工藤景子, 栗尾奈愛, 高橋章, 宮本洋二 : 炭酸アパタイト顆粒(サイトランスグラニュール)を用いて歯槽骨造成を行った2例, 第68 回NPO 法人日本口腔科学会中国・四国地方部会, 2021年11月.
7.	山村佳子, 工藤保誠, 鎌田久美子, 栗尾奈愛, 横田美保, 上杉篤史, 宮本洋二 : 唾液腺の発達・再生におけるΔNp63-Nrep axisの役割, 第66回日本口腔外科学会総会・学術大会, 2021年11月.
8.	鎌田久美子, 栗尾奈愛, 福田直志, 横田美保, 秋田和也, 上杉篤史, 山村佳子, 工藤隆治, 高橋章, 宮本洋二 : 口腔癌術後に多発肺結節を認めた敗血症性肺塞栓症の一例, 第49回(公社)日本口腔外科学会中国四国支部学術集会, 2021年2月.
9.	上杉篤史, 津島文彦, 宮本洋二, 原田浩之 : 大根おろしによる口腔アレルギー症候群の一例, 第33回日本口腔診断学会，第30回日本口腔内科学会, 2020年10月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

機能的スクリーニングから独自に選出した新規microRNAによる口腔癌治療の開発 (研究課題/領域番号: 21K10140 )
癌抑制遺伝子型microRNAの機能的スクリーニングと核酸医薬への応用 (研究課題/領域番号: 25861918 )
研究者番号（20637061）による検索