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Tokushima UniversityUniversity Hospital先端医科医療開発研究プロジェクト
Tokushima UniversityUniversity HospitalClinical DivisionDepartment of Internal MedicineGastroenterology
Tokushima UniversityResearch ClustersResearch Clusters (Registered)2203017 消化器がんと脂肪細胞のクロストーク機構解明による早期診断と標的治療法の開発
Tokushima UniversityFaculty of MedicineSchool of MedicineCourse of Preventive MedicineGastroenteroology and Oncology
Tokushima UniversityGraduate School of MedicineMedicineCourse of Preventive Medicine
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Research

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Academic Paper (Judged Full Paper):

1. Masahiro Sogabe, Toshiya Okahisa, Miwako Kagawa, Takanori Kashihara, Ryo Shinomiya, Takanori Miyake, Tomoyuki Kawaguchi, Reiko Yokoyama, Kaizo Kagemoto, Yoshifumi Kida, Yasuyuki Okada, Tetsu Tomonari, Yutaka Kawano, Yasushi Sato, Masahiko Nakasono and Tetsuji Takayama :
The association between alcohol consumption and cardiometabolic factors and liver fibrosis in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction and alcohol-associated liver disease.,
Alimentary Pharmacology & Therapeutics, Vol.Online ahead of print, 2024.
(DOI: 10.1111/apt.18280,   PubMed: 39310953)
2. Yuya Ueki, Hideki Otsuka, Tamaki Otani, Ryosuke Kasai, Youichi Otomi, Daiki Ikemitsu, Shota Azane, Yamato Kunikane, Takanori Bandoh, Noritake Matsuda, Yasuyuki Okada, Tetsuji Takayama and Masafumi Harada :
Combined visual and quantitative assessment of somatostatin receptor scintigraphy for staging and restaging of neuroendocrine tumors,
Japanese Journal of Radiology, Vol.42, No.5, 519-535, 2024.
(Tokushima University Institutional Repository: 118973,   DOI: 10.1007/s11604-024-01529-z,   PubMed: 38345724)
3. Yasuyuki Okada, Koichi Okamoto, 谷 直也, 和田 浩典, Tomoyuki Kawaguchi, 野田 和克, 宮本 佳彦, 春藤 譲治, Hisanori Uehara and Tetsuji Takayama :
A CASE OF GASTRIC NEUROENDOCRINE TUMOR IN A PATIENT WITH AUTOIMMUNE GASTRITIS COMPLICATED BY TYPE 3 AUTOIMMUNE POLYENDOCRINE SYNDROME TYPE 3,
Gastroenterological Endoscopy, Vol.66, No.3, 259-265, 2024.
(DOI: 10.11280/gee.66.259,   CiNii: 1390299539243025536)
4. Yasuyuki Okada, Peng Fuduan, Perea Jose, Corchete Luis, Bujanda Luis, Li Wei and Goel Ajay :
Genome-wide methylation profiling identifies a novel gene signature for patients with synchronous colorectal cancer,
British Journal of Cancer, Vol.128, No.1, 112-120, 2023.
(Tokushima University Institutional Repository: 118462,   DOI: 10.1038/s41416-022-02033-9,   PubMed: 36319845)
5. Yasushi Sato, Yasuyuki Okada, Yasuteru Fujino, Tomoyuki Kawaguchi, Yoshifumi Kida, Yasuhiro Mitsui, Hironori Tanaka, Tetsu Tomonari, Shinji Kitamura, Koichi Okamoto, Yutaka Kawano, Hiroshi Miyamoto, Masahiro Sogabe and Tetsuji Takayama :
Clinical Outcomes of Comprehensive Genomic Profiling Tests for Gastrointestinal Cancers: Experience from Tokushima University Hospital.,
The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 154-159, 2023.
(Tokushima University Institutional Repository: 118346,   DOI: 10.2152/jmi.70.154,   PubMed: 37164713)
6. hironori wada, Yasuteru Fujino, Kaizo Kagemoto, Yoshifumi Kida, Yasuyuki Okada, Yasuhiro Mitsui, Koichi Okamoto, Yasushi Sato, Yoshimi Bando, Hiroshi Miyamoto and Tetsuji Takayama :
Gastric cancer genome profiling reveals HER2 false-negative status and informs a successful trastuzumab treatment strategy,
The Japanese Journal of Gastro-enterology, Vol.119, No.10, 937-945, 2022.
(DOI: 10.11405/nisshoshi.119.937,   PubMed: 36216544,   CiNii: 1390293710918867840)
7. Beibei Ma, Hiroyuki Ueda, Koichi Okamoto, Masahiro Bando, Shota Fujimoto, Yasuyuki Okada, Tomoyuki Kawaguchi, Hironori Wada, Hiroshi Miyamoto, Mitsuo Shimada, Yasushi Sato and Tetsuji Takayama :
TIMP1 promotes cell proliferation and invasion capability of right-sided colon cancers via the FAK/Akt signaling pathway.,
Cancer Science, Vol.113, No.12, 4244-4257, 2022.
(Tokushima University Institutional Repository: 117615,   DOI: 10.1111/cas.15567,   PubMed: 36073574)
8. Jung Gerhard, Hernández-Illán Eva, Lozano J Juan, Sidorova Julia, Muñoz Jenifer, Yasuyuki Okada, Quintero Enrique, Hernandez Goretti, Jover Rodrigo, Carballal Sabela, Cuatrecasas Miriam, Moreno Lorena, Diaz Mireia, Ocaña Teresa, Sánchez Ariadna, Rivero Liseth, Ortiz Oswaldo, Llach Joan, Castells Antoni, Pellisé Maria, Goel Ajay, Batlle Eduard and Balaguer Francesc :
Epigenome-Wide DNA Methylation Profiling of Normal Mucosa Reveals HLA-F Hypermethylation as a Biomarker Candidate for Serrated Polyposis Syndrome,
The Journal of Molecular Diagnostics : JMD, Vol.24, No.6, 674-686, 2022.
(Tokushima University Institutional Repository: 118463,   DOI: 10.1016/j.jmoldx.2022.03.010,   PubMed: 35447336)
9. Yasuteru Fujino, Kumiko Tanaka, Fumika Nakamura, Yoshifumi Kida, Akihiro Hirao, Yasuyuki Okada, Masanori Takehara, Akira Fukuya, Yoshimi Bando and Tetsuji Takayama :
A CASE OF MULTIPLE COLONIC ULCERS CAUSED BY RHEUMATOID VASCULITIS,
Gastroenterological Endoscopy, Vol.63, No.7, 1358-1364, 2021.
(DOI: 10.11280/gee.63.1358,   CiNii: 1390007282525435264)
10. Yasuyuki Okada, Naoki Takahashi, Tetsuji Takayama and Ajay Goel :
LAMC2 promotes cancer progression and gemcitabine resistance through modulation of EMT and ATP-binding cassette transporters in pancreatic ductal adenocarcinoma.,
Carcinogenesis, Vol.42, No.4, 546-556, 2021.
(Tokushima University Institutional Repository: 118465,   DOI: 10.1093/carcin/bgab011,   PubMed: 33624791)
11. Yasuyuki Okada, Satoshi Nisiwada, Kensuke Yamamura, Masayuki Sho, Hideo Baba, Tetsuji Takayama and Ajay Goel :
Identification of laminin γ2 as a prognostic and predictive biomarker for determining response to gemcitabine-based therapy in pancreatic ductal adenocarcinoma.,
European Journal of Cancer, Vol.146, 125-134, 2021.
(Tokushima University Institutional Repository: 118464,   DOI: 10.1016/j.ejca.2020.12.031,   PubMed: 33607476)

Proceeding of International Conference:

1. Yasushi Sato, Kazuyoshi Noda, Yasuyuki Okada, Kensei Nishida, Yutaka Kawano, Toshihito Tanahashi, Masanori Takehara, Yasuteru Fujino, Koichi Okamoto, Hiroshi Miyamoto and Tetsuji Takayama :
Exosomal miR-199a-3p secreted from cancer-associated adipocytes promote pancreatic cancer progression.,
DDW2023, Chicago, May 2023.
2. Yasuyuki Okada, Fuduan Peng, Jose Perea, Luis Bujanda, Tetsuji Takayama, Wei Li and Ajay Goel :
Identification of a Novel Epigenetic Signature for the Identification of Patients with Synchronous Colorectal Cancers.,
Digestive Disease Week2021, May 2021.
3. Yasuyuki Okada, Ya Cui, Satoshi Nishiwada, Eunsung Jun, Fuminori Sonohara, SongCheol Kim, Yasuhiro Koreda, Masayuki Sho, Wei Li, Tetsuji Takayama and Ajay Goel :
Expression Profiling Identifies a Novel miRNA-based Signature for Predicting Local Recurrence in Patients with Pancreatic Ductal Adenocarcinoma.,
Digestive Disease Week2021, May 2021.
4. Yasuyuki Okada, Goel Ajay, Nishiwada Satoshi, Takahashi Naoki and Tetsuji Takayama :
LAMC2 promotes progression and gemcitabine resistance through modulation of EMT and ATP-binding transporters in pancreatic ductal adenocarcinoma,
AACR annual meeting 2021, Apr. 2021.

Proceeding of Domestic Conference:

1. Hiroshi Miyamoto, Ayuka Mineda, Sawaka Yukishige, Soichiroh Sasa, Kei Daizumoto, Tomoya Fukawa, Yasuyuki Okada, Yasuhiro Mitsui, Koichi Okamoto, Yasushi Sato, Hiroyuki Morino and Tetsuji Takayama :
Management of patients with presumed germline pathogenic variant from comprehensive genomic profiling tests.,
日本人類遺伝学会第69回大会, Oct. 2024.
2. Akira Fukuya, Yasushi Sato, Yasuyuki Okada, Koichi Okamoto, Yutaka Kawano, Hiroshi Miyamoto, Tetsuji Takayama, Kaizo Kagemoto and Yoshifumi Kida :
UBR4 は EGFR の内在化を制御することで,大腸癌患者における抗 EGFR 抗体の新規バイオマーカーとなる.,
第21回日本臨床腫瘍学会学術集会, Feb. 2024.
3. Yasuyuki Okada, Hiroshi Miyamoto and Tetsuji Takayama :
膵腫瘍に対するがん遺伝子パネル検査を念頭に置いたEUS-FNAの至適な方法についての検討.,
JDDW2023, Nov. 2023.
4. Yasuyuki Okada, Goel Ajay and Tetsuji Takayama :
膵癌の術後局所再発を予測するmicroRNAパネルの開発.,
JDDW2023, Nov. 2023.
5. 平田 圭市郎, Hiroyuki Ueda, takanori miyake, takanori kashihara, Yasuyuki Okada, Hironori Tanaka, hironori wada, Yasuteru Fujino, Tetsu Tomonari, Tatsuya Taniguchi, Koichi Okamoto, Hiroshi Miyamoto, Takashi Kawanaka, Hitoshi Ikushima, Yoshimi Bando, Yasushi Sato and Tetsuji Takayama :
切除不能・再発膵神経内分泌腫瘍(pancreatic neruoendocrine neoplasm:P-NEN)に対する集学的治療による治療成績の向上.,
第109回日本消化器病学会総会, Apr. 2023.
6. Hironori Wada, Yasuyuki Okada, Tatsuya Taniguchi, Hironori Tanaka, Koichi Okamoto and Tetsuji Takayama :
Wntシグナル伝達経路を標的とした大腸癌の化学予防.,
第81回日本癌学会学術総会, Oct. 2022.
7. Beibei Ma, Hiroyuki Ueda, Koichi Okamoto, Masahiro Bando, Yasuyuki Okada, Mitsuo Shimada, Yasushi Sato and Tetsuji Takayama :
TIMP1 Promotes Cell Proliferation and Invasion Capability of Right-sided Colon Cancers.,
第81回日本癌学会学術総会, Sep. 2022.
8. Yasuyuki Okada, Yasuhiro Mitsui, Shinji Kitamura, Koichi Okamoto, Hiroshi Miyamoto, Yasushi Sato, Naoki Muguruma and Tetsuji Takayama :
LAMC2 is a novel predictive biomarker for gemcitabine-based therapy in pancreatic ductal adenocarcinoma.,
第19回日本臨床腫瘍学会学術集会, Feb. 2022.
9. Hironori Tanaka, Tetsu Tomonari, kaizo kagemoto, Yasuyuki Okada, hironori wada, Fumika Nakamura, Shinji Kitamura, Koichi Okamoto, Hiroshi Miyamoto, Yasushi Sato, Naoki Muguruma and Tetsuji Takayama :
免疫チェックポイント阻害薬投与中の肝障害.,
第59回日本癌治療学会学術集会, Oct. 2021.
10. Beibei Ma, Hiroyuki Ueda, Naoki Muguruma, Koichi Okamoto, Tomoyuki Kawaguchi, Akira Fukuya, Yoshifumi Kida, Yasuyuki Okada, Tatsuya Taniguchi, Yasushi Sato and Tetsuji Takayama :
Activation of EGFR signaling pathway in the left-side colorectal cancerLeft-side vs. right-side cancer organoids.,
第80回日本癌学会学術総会, Sep. 2021.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 膵癌の診断マーカーとなるexosome内のmiRNAモデルの開発 (Project/Area Number: 24K18918 )
  • Exosomeエンジニアリングによる膵癌とその微小環境の改変を標的とする治療法の開発 (Project/Area Number: 23K27588 )
  • AIを用いた切除可能膵癌に対する化学療法最適化を予測するためのmiRNAモデルの開発 (Project/Area Number: 23K07396 )
  • 染色体不安定性に着目した大腸癌の抗癌剤耐性機序の解析 (Project/Area Number: 23K24321 )
  • AIを用いた膵癌の化学療法の治療効果を予測するmiRNAモデルの開発 (Project/Area Number: 22K16045 )
  • Search by Researcher Number (60815447)