徳島大学 / 教育研究者総覧 --- 保坂啓一

個人のホームページ

https://researchmap.jp/keiichihosaka (researchmap)

https://orcid.org/0000-0002-8471-358X (ORCID)

専門分野

○	Regenerative dental medicine
○	Biomaterials
○	Bioengineering

研究テーマ

○	Pulp regeneration, Adhesively-bonded biological restoration
○	Dental adhesives, Composite resins, Dental Ceramics
○	THz imaging, Super-high-speed imaging

著書・論文

著書:

1.	吉山昌宏, 宮崎真至, 須崎明, 向井義晴, 保坂啓一, 米倉和秀, 伊田百美香, 高木仲人, 大原直子 : 超速でわかる象牙質知覚過敏 Dr.とDHのための最新知識と製品情報, 2024年3月.
2.	吉山昌宏, 宮崎真至, 保坂啓一 : 超速でわかる象牙質知覚過敏 : Dr.とDHのための最新知識と製品情報, クインテッセンス出版株式会社, 2024年3月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1130580904128571038 (CiNii: 1130580904128571038)
3.	Vilaboa R. Debora, Vilaboa R. Beatriz, Reuss Manuel Jose, Reuss Debora, 田上順次, 保坂啓一, 宮崎真至, 島田康史, 高橋真広, 上津原悟郎, 今村俊博, 塩田真, 宮城和彦, 西村耕三 : TOOTH WEAR: 保存・修復の真髄を求めて, クインテッセンス出版株式会社, 2023年10月.
4.	保坂啓一 : ハイエンドなSkill&knowledgeを活かしたワンランク上のコンポジットレジン修復, 株式会社ヒョーロン・パブリッシャーズ, 2023年10月.
5.	保坂啓一 : ワンランク上のコンポジットレジン修復 : ハイエンドなSkill&Knowledgeを活かした, ヒョーロン・パブリッシャーズ, 2023年10月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1130579200986124206 (CiNii: 1130579200986124206)
6.	保坂啓一, 米倉和秀 : 保存修復学専門用語集(第3版), 医歯薬出版株式会社, 2023年3月.
7.	細川育子, 鴨居浩平, 保坂啓一 : エキスパートから学ぶ!CR修復の超レベルアップ30 ---23 デジタルワークフローを活用したインジェクションテクニック---, 2022年4月.
8.	保坂啓一, 田代浩史, 菅原佳広 : エキスパートから学ぶ!CR修復超レベルアップ30, 株式会社デンタルダイヤモンド社, 2022年3月.
9.	岩田隆紀, 水谷幸嗣, 岩野義弘, 松浦孝典, 保坂啓一, 畑山貴志 : 歯科衛生士・歯科助手おしごとハンドブック, クインテッセンス出版株式会社, 2022年3月.
10.	保坂啓一, 畑山貴志, 米倉和秀 : 手に取るようにわかるコンポジットレジン修復のメソッド, 医歯薬出版株式会社, 2022年3月.
11.	田上順次, 奈良陽一郎, 山本一世, 斎藤隆史, 保坂啓一 : 保存修復学21第6版, 永末書店, 2022年2月.
12.	宮崎真至, 田代浩史, 保坂啓一, 秋本尚武 : ユニバーサルシェードを使いこなす, 医歯薬出版株式会社, 東京, 2021年11月.
13.	宮崎真至, 高橋真広, 保坂啓一 : 接着システムの取り扱い―確実な接着を獲得するために, ヒョーロン・パブリッシャーズ, 2021年10月.
14.	石原洋樹, 保坂啓一, 中島正俊 : 誌上デンタルショー使ってみたい歯科のベストアイテム2021, --- 歯科用マトリックスバンドバイオクリアーブラックトライアングルキット ---, 株式会社デンタルダイヤモンド社, 東京, 2021年3月.
15.	宮崎真至, 秋本尚武, 保坂啓一 : コンポジットレジン修復の効率UP 短い時間で・無駄なく・ミスなく審美性を獲得!, 医歯薬出版株式会社, 東京, 2020年4月.
16.	保坂啓一 : ダイレクトクラウンとダイレクトブリッジ ∼The power of Direct Composite Restoration∼ [DVD], Doctorbook, 東京, 2020年3月.
17.	保坂啓一 : 患者満足度を高める審美歯科のQ&A32 美しさと機能性の共存を目指して, --- Q14正中離開の直接修復に用いる隔壁法と審美的な形態付与の方法について教えて下さい ---, 株式会社デンタルダイヤモンド社, 東京, 2019年10月.
18.	田上順次, 保坂啓一, 他 : コンポジットレジンによる最新MI修復東京医科歯科大学田上教室の研究と臨床, 医歯薬出版株式会社, 東京, 2019年6月.
19.	保坂啓一 : もう悩まない!時代が求める接着臨床, --- (第2章)保存関連の接着ダイレクト修復がうまくなりたい成功のための臨床ステップ ---, 株式会社デンタルダイヤモンド社, 東京, 2018年7月.
20.	保坂啓一 : 象牙質知覚過敏症第3版目からウロコのパーフェクト治療ガイド / 冨士谷盛興・千田彰編著, --- 第4章 3.ウルトライーズ ---, 医歯薬出版株式会社, 東京, 2017年10月.
21.	田上順次, 奈良陽一郎, 山本一世, 斎藤隆史, 保坂啓一, 他 : 第五版保存修復学21, 永末書店, 京都, 2017年3月.
22.	保坂啓一 : 日本歯科評論増刊2016 接着の論点 / 松村英雄・二階堂徹編著, --- CQ15 ダイレクトコンポジットレジンブリッジの接着のコツは? ---, 株式会社ヒョーロン・パブリッシャーズ, 東京, 2016年10月.
23.	保坂啓一 : 接着歯学第2版 / 日本接着歯学会編, --- 接着ブリッジ(コンポジットレジンの応用) ---, 医歯薬出版株式会社, 東京, 2015年12月.
24.	保坂啓一 : 接着治療失敗回避のためのポイント45 -なぜ付かないのか，なぜ治らないのか- / 安田登・二階堂徹・秋本尚武・遠山佳之編著, --- Direct Filling Edition4 接着システムからみたボンディング材の種類∼セルフエッチングシステムの上手な取り扱い∼， Direct Filling Edition7 ワンステップボンディングシステム(1液性ボンディング材)の特徴と正しい使用方法 ---, クインテッセンス出版株式会社, 東京, 2010年5月.

学術論文(審査論文):

1.	Takaaki Sato, Keiichi Hosaka, Junji Tagami, Hirofumi Tashiro, Hitoshi Miki, Kazunori Otani, Miho Nishimura, Masahiro Takahashi, Yasushi Shimada and Masaomi Ikeda : Clinical evaluation of direct composite versus zirconia resin-bonded fixed dental prostheses for a single missing anterior tooth: A short-term multicenter retrospective study., Journal of Dentistry, Vol.151, 2024. (要約) Despite differences in material strength, CR-RBFDPs without fiber reinforcement showed reliable short-term clinical results. This direct composite restoration has the advantage of being less invasive and can be restored in a single visit. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jdent.2024.105401 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39384059 ● Search Scopus @ Elsevier (PMID): 39384059 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jdent.2024.105401 (DOI: 10.1016/j.jdent.2024.105401, PubMed: 39384059)
2.	Risa Okamoto, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Keiichi Hosaka : Cardamonin inhibits the expression of inflammatory mediators in TNF-α-stimulated human periodontal ligament cells., Immunopharmacology and Immunotoxicology, 1-8, 2024. (要約) We show that cardamonin reduces inflammatory mediator production by inhibiting the activation of several signaling pathways in this manuscript. (出版サイトへのリンク) ● Publication site (DOI): 10.1080/08923973.2024.2373217 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38918176 ● Search Scopus @ Elsevier (PMID): 38918176 ● Search Scopus @ Elsevier (DOI): 10.1080/08923973.2024.2373217 (DOI: 10.1080/08923973.2024.2373217, PubMed: 38918176)
3.	Keiichiro Watanabe, Eiji Tanaka, Kohei Kamoi, Antonin Tichy, Takahiko Shiba, Kazuhide Yonerakura, Masatoshi Nakajima, Ruonan Han and Keiichi Hosaka : A dual composite resin injection molding technique with 3D-printed flexible indices for biomimetic replacement of a missing mandibular lateral incisor., Journal of Prosthodontic Research, 2024. (要約) The bilayered direct composite RBFPD using 3D printed flexible indices prepared with a full digital workflow has several advantages over other dental prosthetic solutions, including noninvasiveness, cost-effectiveness, biomimetic esthetics, repairability, and shortened treatment times. Although the initial results are promising, further longitudinal studies with larger patient cohorts are required to confirm the long-term efficacy of this approach. (出版サイトへのリンク) ● Publication site (DOI): 10.2186/jpr.JPR_D_23_00239 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38479888 ● Search Scopus @ Elsevier (PMID): 38479888 ● Search Scopus @ Elsevier (DOI): 10.2186/jpr.JPR_D_23_00239 (DOI: 10.2186/jpr.JPR_D_23_00239, PubMed: 38479888)
4.	Hiroki Ishihara, Kazuhide Yonekura, Masaomi Ikeda, Go Inoue, Masatoshi Nakajima, Yasushi Shimada and Keiichi Hosaka : Comparative bonding performance of coronal dentin disks and CAD/CAM resin composite disks for biological restoration: The impact of resin-coating technique., Dental Materials Journal, Vol.43, No.2, 303-311, 2024. (要約) This study evaluated the bonding performance of coronal dentin disks, designed for biological restoration, and CAD/CAM resin composite disks when bonded to flat dentin surfaces using dual-cure resin cements, with and without a resin-coating (RC) technique. Three distinct groups were established within the non-RC group, each using one of the two types of resin cements in a self-adhesive mode: one-step self-etch adhesive (1-SEA) without light-cure, 1-SEA with light-cure, and a separate group using an alternate cement. Within the RC group, a subgroup was established for each cement. The microtensile bond strength (μTBS) of the disk-dentin beam was tested after 0 and 10,000 thermocycles in a 5°C/55°C. No significant μTBS difference was observed among the non-RC groups. However, when using RC, the μTBSs of coronal dentin disks significantly exceeded those of CAD/CAM resin composite disks. Thermocycle aging did not affect μTBS in any of the bonding methods, except in self-adhesive mode. (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2023-229 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38447979 ● Search Scopus @ Elsevier (PMID): 38447979 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2023-229 (DOI: 10.4012/dmj.2023-229, PubMed: 38447979)
5.	Risa Okamoto, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Keiichi Hosaka : Cardamonin decreases inflammatory mediator expression in IL-1β-stimulated human periodontal ligament cells., Molecular Biology Reports, Vol.51, No.1, 2024. (要約) In this study, we found that cardamonin could suppress the production of inflammatory mediators in HPDLCs as well as the activation of several signaling pathways induced by IL-1β treatment. (キーワード) Chalcones / Interleukin-1beta / Periodontal Ligament / NF-kappa B / Cytokines / Cyclooxygenase 2 / Chemokines / Inflammation Mediators (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s11033-023-09204-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38281189 ● Summary page in Scopus @ Elsevier: 2-s2.0-85183370663 (DOI: 10.1007/s11033-023-09204-8, PubMed: 38281189, Elsevier: Scopus)
6.	冨士谷盛興, 森尾郁子, 關奈央子, 保坂啓一, 吉川一志, 峯篤史, 友田篤臣, 川口陽子 : 歯学領域における国際的人材育成に関する調査, 日本歯科医学会連合雑誌, Vol.advpub, No.0, 36-43, 2023年. (要約) <b>目的:</b>歯学領域の国際的人材育成に関する情報収集を目的に本調査を実施した．<br> <b>方法:</b>日本歯科医学教育学会発行の『歯科医学教育白書』(計5冊)の国際交流に関するデータ，および2022年に日本歯科医学会連合が実施した調査をもとに，わが国の歯学領域における国際的人材育成のあり方について検討した．<br> <b>結果:</b>わが国の29歯科大学で学ぶ外国人留学生数は，287名(2009年)，325名(2012年)，514名(2014年)，766名(2017年)，988名(2021年)と経時的に増加し，学士あるいは博士の課程を修めるアジア諸国出身者がいずれの年も90%以上を占めていた．一方，日本人教員等は概ね2年以内の期間，客員研究員，教員として海外留学しており，その留学先の90%以上が欧米諸国であった．<br> <b>結論:</b>この国際交流の相違点を踏まえ，各国の歯科保健医療状況の相互理解を進めていくことが，わが国の歯学領域における国際的人材の育成，延いては国際化推進に寄与すると考えられた． (キーワード) 国際的人材育成 / 海外留学 / 海外研修 / 留学生 / 歯学教育 / 国際化推進 (出版サイトへのリンク) ● Publication site (DOI): 10.57468/jjdsf.23-003 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390579996560712576 ● Search Scopus @ Elsevier (DOI): 10.57468/jjdsf.23-003 (DOI: 10.57468/jjdsf.23-003, CiNii: 1390579996560712576)
7.	Suriyakul Wongsue, Ornnicha Thanatvarakorn, Taweesak Prasansuttiporn, Piyarat Nimmanpipug, Thanapat Sastraruji, Keiichi Hosaka, M Richard Foxton and Masatoshi Nakajima : Effect of surface topography and wettability on shear bond strength of Y-TZP ceramic., Scientific Reports, Vol.13, No.1, 2023. (要約) on the μSBS were analyzed by multiple linear regression analysis (p < 0.05). Multiple regression analysis revealed that the nSI% was the most predominant factor for the μSBS (p < 0.001). A surface with larger nSI%, higher Ra and relatively lower θ (徳島大学機関リポジトリ) ● Metadata: 119456 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-023-45510-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37880480 ● CiNii @ 国立情報学研究所 (CRID): 1871991017928252672 ● Summary page in Scopus @ Elsevier: 2-s2.0-85174703596 (徳島大学機関リポジトリ: 119456, DOI: 10.1038/s41598-023-45510-8, PubMed: 37880480, CiNii: 1871991017928252672, Elsevier: Scopus)
8.	Yoshitaka Hosokawa, Ikuko Hosokawa, Masahiro Shimoyama, Risa Okamoto, Kazumi Ozaki and Keiichi Hosaka : The effects of berteroin on inflammatory mediators and antioxidant enzymes expression in human periodontal ligament cells., Naunyn-Schmiedeberg's Archives of Pharmacology, 2023. (要約) Berteroin is a bioactive substance classified as an isothiocyanate found in cruciferous vegetables such as cabbage, arugula, and salad leaves. In this study, we aimed to determine whether berteroin exerts anti-inflammatory effects on human periodontal ligament cells (HPDLCs), a resident cells of periodontal tissue. Berteroin suppressed interleukin (IL)-1β or tumor necrosis factor (TNF)-α-induced chemokines (C-C motif chemokine ligand (CCL)2, CCL20, C-X-C motif chemokine ligand (CXCL)10, IL-8, and IL-6) production and intercellular adhesion molecule (ICAM)-1 expression in HPDLCs. In addition, berteroin inhibited phosphorylation of IκB kinase (IKK)- α/ β, nuclear factor (NF)- κB p65, and IκB- α and degradation of IκB- α in the NF-κB pathway induced by IL-1 β or TNF- α stimulation. Moreover, berteroin could inhibit signal transducer and activator of transcription (STAT)3 phosphorylation in TNF- α -stimulated HPDLC. Furthermore, berteroin increased the expression of the antioxidant enzymes, heme oxygenase (HO)-1 and NAD(P)H quinone dehydrogenase (NQO)1, in IL-1 β or TNF- α -stimulated HPDLCs. These results suggest that berteroin may decrease the production of inflammatory mediators in HPDLCs by suppressing the NF-κB pathway, and may also decrease the local reactive oxygen species (ROS) production in periodontal lesions by increasing the production of antioxidant enzymes. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00210-023-02761-6 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37804343 ● Search Scopus @ Elsevier (PMID): 37804343 ● Search Scopus @ Elsevier (DOI): 10.1007/s00210-023-02761-6 (DOI: 10.1007/s00210-023-02761-6, PubMed: 37804343)
9.	Masahiro Shimoyama, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Keiichi Hosaka : Effects of erucin on inflammatory mediators and antioxidant enzymes' expression in TNF-α-stimulated human oral epithelial cells., Immunopharmacology and Immunotoxicology, Vol.46, No.1, 49-54, 2023. (要約) These results suggest that erucin may provide a new anti-inflammatory agent that can be used in the treatment of periodontitis. (キーワード) Humans / Tumor Necrosis Factor-alpha / Antioxidants / Inflammation Mediators / Epithelial Cells / NF-kappa B / Chemokines / Periodontitis / Sulfides / Thiocyanates (徳島大学機関リポジトリ) ● Metadata: 119317 (出版サイトへのリンク) ● Publication site (DOI): 10.1080/08923973.2023.2250551 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37624680 ● Search Scopus @ Elsevier (PMID): 37624680 ● Search Scopus @ Elsevier (DOI): 10.1080/08923973.2023.2250551 (徳島大学機関リポジトリ: 119317, DOI: 10.1080/08923973.2023.2250551, PubMed: 37624680)
10.	Antonín Tichý, Yi Yang, Mahmoud Sayed, Yasushi Shimada and Keiichi Hosaka : The Effect of Bonding Strategy and Aging on Adhesion to Primary Enamel: An In-Vitro Study., The Journal of Adhesive Dentistry, Vol.25, No.1, 187-194, 2023. (要約) The 3-ER strategy is optimal for bonding to primary enamel. The etching effect of SE strategies is weaker, resulting in lower µSBS. Thermocycling revealed that the bonding durability of the 1-SE strategy is inferior to that of to multi-step strategies. (出版サイトへのリンク) ● Publication site (DOI): 10.3290/j.jad.b4515497 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37843501 ● Search Scopus @ Elsevier (PMID): 37843501 ● Search Scopus @ Elsevier (DOI): 10.3290/j.jad.b4515497 (DOI: 10.3290/j.jad.b4515497, PubMed: 37843501)
11.	Keiichi Hosaka, Antonin Tichy, Monica Yamauti, Keiichiro Watanabe, Kohei Kamoi, Kazuhide Yonekura, Richard Foxton and Masatoshi Nakajima : Digitally Guided Direct Composite Injection Technique with a Bi-layer Clear Mini-Index for the Management of Extensive Occlusal Caries in a Pediatric Patient: A Case Report., The Journal of Adhesive Dentistry, Vol.25, No.1, 211-218, 2023. (要約) The injection technique with a bi-layer clear mini-index accurately translated the digital wax-ups into large, final restorations. Precise morphology and shortened chair time enhanced patient satisfaction, but at the expense of multiple visits. (徳島大学機関リポジトリ) ● Metadata: 118656 (出版サイトへのリンク) ● Publication site (DOI): 10.3290/j.jad.b4515527 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37843503 ● Search Scopus @ Elsevier (PMID): 37843503 ● Search Scopus @ Elsevier (DOI): 10.3290/j.jad.b4515527 (徳島大学機関リポジトリ: 118656, DOI: 10.3290/j.jad.b4515527, PubMed: 37843503)
12.	Keiichiro Watanabe, A Tichy, Kouhei Kamoi, Masahiro Hiasa, Kazuhide Yonekura, Eiji Tanaka, M Nakajima and Keiichi Hosaka : Restoration of a Microdont Using the Resin Composite Injection Technique With a Fully Digital Workflow: A Flexible 3D-printed Index With a Holding Clip., Operative Dentistry, 2023. (要約) Direct composite restorations are accepted as a treatment option for microdontia, which is a relatively prevalent condition that poses esthetic concerns. While free-hand composite placement is technique-sensitive and time-consuming, the resin composite injection technique is more straightforward and predictable. A fully digital workflow has been recently introduced, but the 3D-printed resin index is rigid and challenged by undercuts, as opposed to the silicone index. This case report presents a flexible 3D-printed resin index, which can accurately transfer the digitally simulated functional and esthetic form to the final restoration. In addition, a rigid holding clip was designed to stabilize the flexible index. (出版サイトへのリンク) ● Publication site (DOI): 10.2341/23-007 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37503684 ● Search Scopus @ Elsevier (PMID): 37503684 ● Search Scopus @ Elsevier (DOI): 10.2341/23-007 (DOI: 10.2341/23-007, PubMed: 37503684)
13.	Dhaifallah Alqarni, Masatoshi Nakajima, Junji Tagami, S Mohammed Alzahrani, Clara Ana Sá-Pinto, Ali Alghamdi, Keiichi Hosaka, Fouad Alzahrani, A Omar Alsadon, A Raed Alharbi, S Shaia Almalki and H Abdullah Ali Alzahrani : Study of Streptococcus mutans in Early Biofilms at the Surfaces of Various Dental Composite Resins., Curēus, Vol.15, No.4, e38090, 2023. (要約) Biofilm deposit on the composite restoration is a common phenomenon and bacterial growth follows the deposition. The study aims to evaluate () early biofilm formation on the surfaces of various dental composite resins by using the real-time quantitative polymerase chain reaction (qPCR) technique. Thirty-two discs, where eight discs were in each group of Filtek Supreme Ultra (FSU; 3M, St. Paul, MN), Clearfil AP-X (APX; Kuraray Noritake Dental Inc., Tokyo, Japan), Beautifil II (BE2; Shofu, Inc., Kyoto, Japan), and Estelite Sigma Quick (ESQ; Tokuyama Dental, Tokyo, Japan), were fabricated and subjected to biofilm formation in an oral biofilm reactor for 12 hours. Contact angles (CA) were measured on the freshly fabricated specimen. The attached biofilms underwent fluorescent microscopy (FM). from biofilms were analyzed using a qPCR technique. Surface roughness (Sa) measurements were taken before and after biofilm formation. Scanning electron microscopy (SEM), including energy dispersive X-ray spectrometer (EDS) analysis, was also performed for detecting relative elements on biofilms. The study showed that FSU demonstrated the lowest CA while APX presented the highest values. FM revealed that condensed biofilm clusters were most on FSU. The qPCR results indicated the highest DNA copies in the biofilm were on FSU while BE2 was the lowest (p < 0.05). Sa test signified that APX was significantly the lowest among all materials while FSU was the highest (p < 0.05). SEM displayed areas with apparently glucan-free more on BE2 compared to APX and ESQ, while FSU had the least. Small white particles detected predominantly on the biofilms of BE2 appeared to be Si, Al, and F extruded from the resin. Differences in early biofilm formation onto various composite resins are dependent on the differences in material compositions and their surface properties. BE2 showed the lowest quantity of biofilm accumulation compared to other resin composites (APX, ESQ, and FSU). This could be attributed to BE2 proprieties as a giomer and fluoride content. (出版サイトへのリンク) ● Publication site (DOI): 10.7759/cureus.38090 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37252523 ● Search Scopus @ Elsevier (PMID): 37252523 ● Search Scopus @ Elsevier (DOI): 10.7759/cureus.38090 (DOI: 10.7759/cureus.38090, PubMed: 37252523)
14.	Satoshi Akiya, Kento Sato, Kouta Kibe, Antonin Tichy, Noriko Hiraishi, Taweesak Prasansuttiporn, Keiichi Hosaka, M Richard Foxton, Yasushi Shimada and Masatoshi Nakajima : Polymerization shrinkage of light-cured conventional and bulk-fill composites -The effect of cavity depth and post-curing., Dental Materials Journal, 2023. (要約) decreased significantly between 2 mm and 3 mm (p<0.05), but %VH exceeded 90% even in 5 mm deep cavities. These results indicated that post-curing contributed to lower shrinkage in deeper layers, and that conventional RBCs were not adequately polymerized at the depth of over 3 mm. (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2022-210 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37032103 ● Search Scopus @ Elsevier (PMID): 37032103 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2022-210 (DOI: 10.4012/dmj.2022-210, PubMed: 37032103)
15.	Kiyoka Furusawa, Shun Kobayashi, Ako Yamashita, Antonin Tichy, Keiichi Hosaka, Yasushi Shimada and Masatoshi Nakajima : Effect of filler load on structural coloration and color adjustment potential of resin composites., Dental Materials Journal, Vol.42, No.3, 343-350, 2023. (要約) The color-matching ability of single-shade composites Omnichroma (OMN) and Omnichroma Flow (OCF) is ensured by structural color, which arises from monodisperse 260 nm spherical fillers. This study evaluated how filler load influences the color adjustment potential of composite restorations to human teeth of various shades. The performance of composites containing the 260 nm spherical fillers -OMN (79 wt%), OCF (71 wt%), and experimental composites R1 (65 wt%), and R2 (60 wt%)- was compared to two conventional A2-shade composites and a transparent composite. Additionally, the translucency parameter, spectral reflectance, and light transmission properties were assessed. Composites with a lower load of the 260 nm spherical fillers exhibited lower light diffusion and lower reflectance in the yellow-to-red range (580-650 nm), which is characteristic for the structural color of OMN and OCF. The best color adjustment was achieved with OCF, presumably due to its high translucency and uniform spectral reflectance. (キーワード) Humans / Color / Materials Testing / Composite Resins (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2022-199 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36709985 ● Summary page in Scopus @ Elsevier: 2-s2.0-85151500630 (DOI: 10.4012/dmj.2022-199, PubMed: 36709985, Elsevier: Scopus)
16.	Ako Yamashita, Shun Kobayashi, Kiyoka Furusawa, Antonin Tichy, Rena Oguro, Keiichi Hosaka, Yasushi Shimada and Masatoshi Nakajima : Does the thickness of universal-shade composites affect the ability to reflect the color of background dentin?, Dental Materials Journal, 2023. (要約) The recently introduced resin composites with a universal shade are claimed to match any tooth color. In this study, it was examined how composite thickness affects the color adjustment of conventional and universal-shade composites to background dentin. Thirty sound human central incisors of various shade were used, and color differences between their intact labial surfaces, exposed dentin surfaces and composite restorations (thickness 1-3 mm) were evaluated. In addition, the translucency, light transmission characteristics, and spectral reflectance of the composites were measured. The results showed that universal-shade composites outperformed conventional composites of A2 shade in the adjustment of hue and chroma (p<0.05) but not in lightness (p>0.05). The color adjustment potential of all composites significantly decreased as their thickness increased (p<0.05). The effect of thickness on Omnichroma and Omnichroma Flow was less marked, presumably because of their higher translucency (p<0.05) and structural coloration which induces light reflectance in the yellow-to-red range. (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2022-197 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36624077 ● Search Scopus @ Elsevier (PMID): 36624077 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2022-197 (DOI: 10.4012/dmj.2022-197, PubMed: 36624077)
17.	Yuna Kanamori, Naoko Seki, Richard Foxton, Janelle Moross, Yuriko Komagamine, Koji Mizutani, Keiichi Hosaka, Manabu Kanazawa, Takashi Hatayama, Wataru Komada, Ikuo Yonemitsu, Masako Akiyama, Chiewpattanakul Paramaporn Kaewmanee, Nathawut Kaewsutha, Hiroshi Nitta, Noriyuki Wakabayashi and Ikuko Morio : Fostering globally competent dental students through virtual team-working, problem-solving and person-centred multi-disciplinary care planning., Journal of Dental Sciences, Vol.18, No.1, 95-104, 2023. (要約) Fostering globally competent dental students is important and the acquisition of necessary skill sets could be enhanced through international virtual team-working, problem-solving and person-centred multi-disciplinary care planning activities. These are beneficial for undergraduate dental student training so that they graduate with a broader global perspective and an appreciation of the importance of delivering person-centred culturally sensitive dental care. (徳島大学機関リポジトリ) ● Metadata: 118026 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jds.2022.07.004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36643270 ● Search Scopus @ Elsevier (PMID): 36643270 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jds.2022.07.004 (徳島大学機関リポジトリ: 118026, DOI: 10.1016/j.jds.2022.07.004, PubMed: 36643270)
18.	Yoshitaka Hosokawa, Ikuko Hosokawa, Masahiro Shimoyama, Ayumi Fujii, Juri Sato, Kimitake Kadena, Kazumi Ozaki and Keiichi Hosaka : The Anti-Inflammatory Effects of Iberin on TNF-α-Stimulated Human Oral Epithelial Cells: In Vitro Research., Biomedicines, Vol.10, No.12, 2022. (要約) Iberin is a bioactive chemical found in cruciferous plants that has been demonstrated to have anticancer properties. However, there have been no reports on its effects on periodontal resident cells, and many questions remain unanswered. The aim of this study was to examine whether iberin had anti-inflammatory effects on human oral epithelial cells, including influences on signal transduction pathway activation in TNF-α-στιμυλατεd χελλσ. Iberin inhibited the production of interleukin (IL)-6 and C-X-C motif chemokine ligand 10 (CXCL10), as well as the expression of vascular cell adhesion molecule (VCAM)-1, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2 in tumor necrosis factor (TNF)-α-stimulated TR146 cells, a human oral epithelial cell line. Moreover, iberin administration increased the expression of antioxidant signaling pathways, such as Heme Oxygenase (HO)-1 and NAD(P)H quinone dehydrogenase 1 (NQO1). Furthermore, we found that iberin could inhibit the activation of the nuclear factor (NF)-κB, signal transducer and activator of transcription (STAT)3, and p70S6 kinase (p70S6K)-S6 ribosomal protein (S6) pathways in TNF-α-stimulated TR146 cells. In conclusion, iberin reduced inflammatory mediator expression in human oral epithelial cells by preventing the activation of particular signal transduction pathways. (徳島大学機関リポジトリ) ● Metadata: 118001 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/biomedicines10123155 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36551911 ● Search Scopus @ Elsevier (PMID): 36551911 ● Search Scopus @ Elsevier (DOI): 10.3390/biomedicines10123155 (徳島大学機関リポジトリ: 118001, DOI: 10.3390/biomedicines10123155, PubMed: 36551911)
19.	Yutaro Motoyama, Monica Yamauti, Masatoshi Nakajima, Masaomi Ikeda, Junji Tagami, Yasushi Shimada and Keiichi Hosaka : Hydroxyapatite Affects the Physicochemical Properties of Contemporary One-Step Self-Etch Adhesives., Materials, Vol.15, No.22, 8255, 2022. (要約) -test with Bonferroni corrections (α = 0.05). When adhesives were manipulated on the HA plate, there was a significant increase in the adhesives' pH. WS and SL of all 1-SEAs decreased when the HA was used. Only SBU showed higher flexural strength when manipulated on the HA compared to the manipulation on TD under dry and wet conditions. For each 1-SEA, the use of HA resulted in significantly higher E in dry and wet conditions. ΔE of all adhesives was smaller with the manipulation on HA than on TD. It was concluded that the manipulation of 1-SEA on a hydroxyapatite plate considerably affected the adhesives' properties. (徳島大学機関リポジトリ) ● Metadata: 118066 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ma15228255 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36431740 ● Search Scopus @ Elsevier (PMID): 36431740 ● Search Scopus @ Elsevier (DOI): 10.3390/ma15228255 (徳島大学機関リポジトリ: 118066, DOI: 10.3390/ma15228255, PubMed: 36431740)
20.	Hitomi Kuramoto, Tadashi Nakanishi, Daisuke Takegawa, MIEDA Katsuhiro and Keiichi Hosaka : Caffeic Acid Phenethyl Ester Induces Vascular Endothelial Growth Factor Production and Inhibits CXCL10 Production in Human Dental Pulp Cells, Current Issues in Molecular Biology, Vol.44, No.11, 5691-5699, 2022. (要約) The survival rate of root non-vital teeth is lower than that of vital teeth. Therefore, to preserve the dental pulp is very important. The vascular endothelial growth factor (VEGF) is the most potent angiogenic factor involved in the vitality of dental pulp including reparative dentin formation. Caffeic acid phenethyl ester (CAPE) is a physiologically active substance of propolis and has some bioactivities such as anti-inflammatory effects. However, there are no reports on the effects of CAPE on dental pulp inflammation. In this study, we investigated the effects of CAPE on VEGF and inflammatory cytokine production in human dental pulp cells (HDPCs) to apply CAPE to an ideal dental pulp protective agent. We found that CAPE induced VEGF production from HDPCs. Moreover, CAPE induced the phosphorylation of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases (ERK), and stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) in HDPCs. Furthermore, CAPE inhibited C-X-C motif chemokine ligand 10 (CXCL10) production in Pam3CSK4- and tumor necrosis factor-alpha (TNF-α)-stimulated HDPCs. In conclusion, these results suggest that CAPE might be useful as a novel biological material for vital pulp therapy by exerting the effects of VEGF production and anti-inflammatory activities. (キーワード) anti-inflammatory effect / caffeic acid phenethyl ester / dental pulp cells / 歯髄炎 (pulpitis) / 血管内皮増殖因子 (vascular endothelial growth factor) / vital pulp therapy (徳島大学機関リポジトリ) ● Metadata: 117775 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/cimb44110385 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36421669 ● Search Scopus @ Elsevier (PMID): 36421669 ● Search Scopus @ Elsevier (DOI): 10.3390/cimb44110385 (徳島大学機関リポジトリ: 117775, DOI: 10.3390/cimb44110385, PubMed: 36421669)
21.	Kittisak Sanon, Antonin Tichy, Takashi Hatayama, Ornnicha Thanatvarakorn, Taweesak Prasansuttiporn, Takahiro Wada, Yasushi Shimada, Keiichi Hosaka and Masatoshi Nakajima : Addition of metal chlorides to a HOCl conditioner can enhance bond strength to smear layer deproteinized dentin., Dental Materials, Vol.38, No.8, 1235-1247, 2022. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.dental.2022.06.006 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35715250 ● Search Scopus @ Elsevier (PMID): 35715250 ● Search Scopus @ Elsevier (DOI): 10.1016/j.dental.2022.06.006 (DOI: 10.1016/j.dental.2022.06.006, PubMed: 35715250)
22.	Masahiro Shimoyama, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Keiichi Hosaka : 6-(Methylsulfinyl) Hexyl Isothiocyanate Inhibits IL-6 and CXCL10 Production in TNF-α-Stimulated Human Oral Epithelial Cells., Current Issues in Molecular Biology, Vol.44, No.7, 2915-2922, 2022. (要約) 6-(Methylsulfinyl) hexyl isothiocyanate (6-MSITC) is a bioactive substance found in wasabi (Wasabia japonica) and has been reported to have some bioactive effects including anticancer and antioxidant effects. However, there are no reports on its effects on periodontal resident cells, and many points remain unclear. In this study, we aimed to investigate whether 6-MSITC exerts anti-inflammatory effects on human oral epithelial cells, including effects on signal transduction pathway activation. 6-MSITC inhibited interleukin (IL)-6 and C-X-C motif chemokine ligand 10 (CXCL10) production in TNF-α-stimulated TR146 cells, which are a human oral epithelial cell line. Moreover, we found that 6-MSITC could suppress signal transducer and activator of transcription (STAT)3, nuclear factor (NF)-κB, and p70S6 kinase (p70S6K)-S6 ribosomal protein (S6) pathways activation in TNF-α-stimulated TR146 cells. Furthermore, STAT3 and NF-κB inhibitors could suppress IL-6 and CXCL10 production in TNF-α-treated TR146 cells. In summary, 6-MSITC could decrease IL-6 and CXCL10 production in human oral epithelial cell by inhibiting STAT3 and NF-κB activation. (徳島大学機関リポジトリ) ● Metadata: 117734 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/cimb44070201 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35877425 ● Search Scopus @ Elsevier (PMID): 35877425 ● Search Scopus @ Elsevier (DOI): 10.3390/cimb44070201 (徳島大学機関リポジトリ: 117734, DOI: 10.3390/cimb44070201, PubMed: 35877425)
23.	S Wahyuni Dwiandhany, Ahmed Abdou, Antonin Tichy, Kazuhide Yonekura, Masaomi Ikeda, Keiichi Hosaka, Junji Tagami and Masatoshi Nakajima : Additive effects of touch-activated polymerization and extended irradiation time on bonding of light-activated adhesives to root canal dentin., The Journal of Prosthetic Dentistry, 2022. (要約) The purpose of this in vitro study was to investigate the effect of touch-polymerization activators and extended light-irradiation time on the microtensile bond strength (μTBS) of light-activated adhesives. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.prosdent.2020.11.021 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33431177 ● Search Scopus @ Elsevier (PMID): 33431177 ● Search Scopus @ Elsevier (DOI): 10.1016/j.prosdent.2020.11.021 (DOI: 10.1016/j.prosdent.2020.11.021, PubMed: 33431177)
24.	Kittisak Sanon, Antonin Tichy, Ornnicha Thanatvarakorn, Taweesak Prasansuttiporn, Kazuhide Yonekura, Keiichi Hosaka, Masayuki Otsuki and Masatoshi Nakajima : Application of Sulfinate Agent in Conjunction with HOCl Smear -Layer Deproteinization Improves Dentin Bonding Durability of One-step Self-etch Adhesives., The Journal of Adhesive Dentistry, Vol.24, No.1, 223-232, 2022. (要約) To evaluate the effect of a sulfinate agent on the bonding durability of one-step self-etch adhesives (1-SEAs) to smear-layer-covered dentin deproteinized with hypochlorous acid (HOCl). Human coronal dentin disks with a standardized smear layer were deproteinized with 100 ppm HOCl solution for 0 s (control), 15 s or 30 s. After rinsing with water for 30 s and air drying, half of the specimens were treated with a sulfinate agent (Scotchbond Universal Dual Cure Activator; SDA) prior to the application of a 1-SEA (Bond Force II [Tokuyama Dental] or Clearfil Universal Bond Quick [Kuraray Noritake]). Microtensile bond strength (µTBS) was measured after 24 h or 10,000 thermal cycles (TC). The data were analyzed by three-way ANOVA with Tukey's post-hoc tests and t-tests at the 0.05 significance level. The 24-h µTBS of both adhesives increased statistically significantly with the HOCl pretreatment for 15 s or 30 s (p < 0.05), but it was not statistically significantly affected by the application of SDA (p > 0.05). However, after TC, the groups treated with the combination of HOCl and SDA maintained their µTBS (p > 0.05), as opposed to untreated dentin and dentin treated with either HOCl or SDA , whose µTBS decreased significantly (p < 0.05). The application of the sulfinate agent did not statistically significantly affect the immediate bond strength of 1-SEAs, and it could not prevent a significant decrease in the bond strength to untreated dentin after thermocycling. However, the sulfinate agent significantly improved the bonding durability of 1-SEAs to HOCl smear -layer deproteinized dentin. (キーワード) Adhesives / Dental Bonding / Dental Cements / Dentin / Dentin-Bonding Agents / Humans / Hypochlorous Acid / Materials Testing / Resin Cements / Smear Layer / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.3290/j.jad.b2920099 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35418011 ● Search Scopus @ Elsevier (PMID): 35418011 ● Search Scopus @ Elsevier (DOI): 10.3290/j.jad.b2920099 (DOI: 10.3290/j.jad.b2920099, PubMed: 35418011)
25.	保坂啓一, 米倉和秀, 中島正俊, 田上順次, 島田康史, 吉山昌宏 : Advanced MIデンティストリー時代に向かって~新しい接着再生歯科治療~, 象牙質歯髄治療学会雑誌, Vol.2, No.1, 1-7, 2022年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1010294643595988736 (CiNii: 1010294643595988736)
26.	Kittisak Sanon, Takashi Hatayama, Antonin Tichy, Ornnicha Thanatvarakorn, Taweesak Prasansuttiporn, Takahiro Wada, Masaomi Ikeda, Keiichi Hosaka and Masatoshi Nakajima : Smear layer deproteinization with NaOCl and HOCl: Do application/wash-out times affect dentin bonding of one-step self-etch adhesives?, Dental Materials Journal, 2022. (要約) This study investigated the influence of application/wash-out times of sodium hypochlorite (NaOCl) and hypochlorous acid (HOCl) on dentin bond strength of one-step self-etch adhesives (1-SEAs). Human coronal dentin discs with a standardized smear layer were pretreated with 6% NaOCl or 100 ppm HOCl for 5 s, 15 s, or 30 s, and washed out with water for 5 s, 15 s or 30 s with or without the application of Clearfil DC Activator (CDA). No pretreatment was used as a control. The discs were bonded with a 1-SEA (Bond Force II or Clearfil Universal Bond Quick) and microtensile bond strength (µTBS) was measured after 24 h. Pretreatment with NaOCl for 15 s and 30 s significantly decreased µTBS (p<0.05), irrespective of wash-out time. The application of CDA recovered µTBS but did not outperform the control group. Conversely, pretreatment with HOCl for 15 s and 30 s followed by 30 s wash-out time significantly increased µTBS of 1-SEAs (p<0.05), regardless of CDA application. (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2021-208 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35082181 ● Search Scopus @ Elsevier (PMID): 35082181 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2021-208 (DOI: 10.4012/dmj.2021-208, PubMed: 35082181)
27.	Natsumi Saito, Risako Mikami, Koji Mizutani, Kohei Takeda, Hiromi Kominato, Daisuke Kido, Yuichi Ikeda, Prima Buranasin, Keita Nakagawa, Shu Takemura, Takeshi Ueno, Keiichi Hosaka, Takao Hanawa, Tamayuki Shinomura and Takanori Iwata : Impaired dental implant osseointegration in rat with streptozotocin-induced diabetes., Journal of Periodontal Research, 2022. (要約) Acid-treated titanium implants were bilaterally placed in the maxillary alveolar ridge of streptozotocin-induced diabetic (DM group) and control rats after extraction of first molars. Histological analysis and micro-push-out test were performed 4 weeks after surgery. Oxidative stress and osteogenic markers in the surrounding bone were quantified by real-time polymerase chain reaction. In the in vitro study, rat bone marrow-derived mesenchymal stem cells (BMMSCs) were cultured on acid-treated titanium discs in a high-glucose (HG) or normal environment. Intracellular reactive oxygen species (ROS), cell proliferation, alkaline phosphatase (ALP) activity, and extracellular calcification were evaluated following antioxidant treatment with N-acetyl-L-cysteine (NAC). (出版サイトへのリンク) ● Publication site (DOI): 10.1111/jre.12972 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35037248 ● Search Scopus @ Elsevier (PMID): 35037248 ● Search Scopus @ Elsevier (DOI): 10.1111/jre.12972 (DOI: 10.1111/jre.12972, PubMed: 35037248)
28.	Antonin Tichy, Keiichi Hosaka, Yi Yang, Yutaro Motoyama, Yasunori Sumi, Masatoshi Nakajima and Junji Tagami : Can a New HEMA-free Two-step Self-etch Adhesive Improve Dentin Bonding Durability and Marginal Adaptation?, The Journal of Adhesive Dentistry, Vol.23, No.6, 505-512, 2021. (要約) The new 2-SEA exhibited stable dentin bonding and increased hydrophobicity resulting from the absence of hydrophilic monomers. (出版サイトへのリンク) ● Publication site (DOI): 10.3290/j.jad.b2288233 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34817966 ● Search Scopus @ Elsevier (PMID): 34817966 ● Search Scopus @ Elsevier (DOI): 10.3290/j.jad.b2288233 (DOI: 10.3290/j.jad.b2288233, PubMed: 34817966)
29.	Dhaifallah Alqarni, Ali Alghamdi, Amr Saad, Abdullah H. Ali Alzahrani and Keiichi Hosaka : Effect of Surface Polishing on Nano-Hardness and Elastic Modulus of Different Resin Composites after Immersion in Alcoholic Medium, Journal of Composites Science, 2021. (徳島大学機関リポジトリ) ● Metadata: 117230 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/jcs5120327 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85121388147 (徳島大学機関リポジトリ: 117230, DOI: 10.3390/jcs5120327, Elsevier: Scopus)
30.	Yorichika Shioya, Antonin Tichy, Kazuhide Yonekura, Mayu Hasegawa, Takashi Hatayama, Masaomi Ikeda, Junji Tagami, Masatoshi Nakajima and Keiichi Hosaka : Sodium p-Toluenesulfinate Enhances the Bonding Durability of Universal Adhesives on Deproteinized Eroded Dentin, Polymers, Vol.13, No.22, 3901, 2021. (徳島大学機関リポジトリ) ● Metadata: 116704 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/polym13223901 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.3390/polym13223901 (徳島大学機関リポジトリ: 116704, DOI: 10.3390/polym13223901)
31.	R Zimmer, L M Leite, A Souza Costa C de, J Hebling, G Anovazzi, A C Klein-Junior, Keiichi Hosaka and D E Reston : Effect of Time and Temperature of Air Jet on the Mechanical and Biological Behavior of a Universal Adhesive System., Operative Dentistry, 2021. (要約) Applying an air blast at 50°C for 20 seconds increases the DC and microtensile bond strength of the 3M Single Bond Universal Adhesive System to dentin, as well as reduces the transdentinal cytotoxicity of the material to pulp cells. (出版サイトへのリンク) ● Publication site (DOI): 10.2341/20-038-L (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34624102 ● Search Scopus @ Elsevier (PMID): 34624102 ● Search Scopus @ Elsevier (DOI): 10.2341/20-038-L (DOI: 10.2341/20-038-L, PubMed: 34624102)
32.	Keiichi Hosaka, Antonin Tichy, Daisuke Araoka, Wurihan Wurihan, Yo Shibata, Masaomi Ikeda, Afonso Celso Klein, Junji Tagami and Masatoshi Nakajima : Eight-year Microtensile Bond Strength to Dentin and Interfacial Nanomechanical Properties of a One-step Adhesive., The Journal of Adhesive Dentistry, Vol.23, No.5, 461-467, 2021. (要約) Although 8 years of water storage did not decrease the µTBS of CS3+ significantly, the observed failure mode patterns and significantly decreased nanomechanical properties indicated resin degradation of the adhesive and the resin composite. (キーワード) Composite Resins / Dental Bonding / Dental Cements / Dental Stress Analysis / Dentin / Dentin-Bonding Agents / Humans / Materials Testing / Resin Cements / Stress, Mechanical / Surface Properties / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.3290/j.jad.b1999815 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34549929 ● Search Scopus @ Elsevier (PMID): 34549929 ● Search Scopus @ Elsevier (DOI): 10.3290/j.jad.b1999815 (DOI: 10.3290/j.jad.b1999815, PubMed: 34549929)
33.	Ali Nooruldeen Saeed, Antonin Tichy, Yusuke Kuno, Keiichi Hosaka, Junji Tagami and Masatoshi Nakajima : Effect of Surface Moisture on Bur-cut Dentin on Bonding of HEMA-free and HEMA-containing Universal Adhesives with or without Methacrylamide Monomer., The Journal of Adhesive Dentistry, Vol.23, No.4, 327-334, 2021. (要約) Dry surfaces enabled obtaining optimal bonding for HEMA-containing adhesives to bur-cut dentin, while wet surfaces enabled optimal bonding for HEMA-free adhesives. Methacrylamide monomers could contribute to the improvement of the initial and long-term bonding performance of universal adhesives to bur-cut dentin. (キーワード) Acrylamides / Adhesives / Composite Resins / Dental Bonding / Dental Cements / Dentin / Dentin-Bonding Agents / Humans / Materials Testing / Methacrylates / Resin Cements / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.3290/j.jad.b1650121 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34269543 ● Search Scopus @ Elsevier (PMID): 34269543 ● Search Scopus @ Elsevier (DOI): 10.3290/j.jad.b1650121 (DOI: 10.3290/j.jad.b1650121, PubMed: 34269543)
34.	Ghassan Rummani, Kurumi Ide, Keiichi Hosaka, Antonin Tichy, Ahmed Abdou, Masayuki Otsuki and Masatoshi Nakajima : Regional ultimate tensile strength and water sorption/solubility of bulk-fill and conventional resin composites: The effect of long-term water storage., Dental Materials Journal, 2021. (要約) increased with depth and storage time, markedly at 3-5 mm after 1 month for conventional composites and after 6 months for bulk-fill composites. The signs of degradation at depths beyond 3 mm suggested that even bulk-fill composites have suboptimal properties in layers more than 3 mm in thickness. (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2021-101 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34305051 ● Search Scopus @ Elsevier (PMID): 34305051 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2021-101 (DOI: 10.4012/dmj.2021-101, PubMed: 34305051)
35.	Ishikawa Kyoko, Yamauti Monica, Ikeda Masaomi, Tichy Antonin, Ueno Takeshi, Wakabayashi Noriyuki, Thanatvarakorn Ornnicha, Prasansuttiporn Taweesak, Klein-Junior Afonso Celso, Takahashi Akifumi, Takagaki Tomohiro, Nakajima Masatoshi, Tagami Junji and Keiichi Hosaka : UV-mediated photofunctionalization of indirect restorative materials enhances bonding to a resin-based luting agent., BioMed Research International, 2021. (徳島大学機関リポジトリ) ● Metadata: 116274 (出版サイトへのリンク) ● Publication site (DOI): 10.1155/2021/9987860 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1155/2021/9987860 (徳島大学機関リポジトリ: 116274, DOI: 10.1155/2021/9987860)
36.	Keiichi Hosaka, Shisei Kubo, Antonin Tichy, Masaomi Ikeda, Koichi Shinkai, Toshio Maseki, Akitomo Rikuta, Hiromi Sasazaki, Kaori Satoh, Morioki Fujitani, Masao Hanabusa, Takatsugu Yamamoto, Kazushi Yoshikawa, Makoto Morigami, Shigeru Uno, Junpei Sugizaki, Hirofumi Yatani and Toru Nikaido : Clinical effectiveness of direct resin composite restorations bonded using one-step or two-step self-etch adhesive systems: A three-year multicenter study., Dental Materials Journal, 2021. (要約) The purpose of this multicenter clinical study was to compare the mid-term clinical effectiveness of direct resin composite restorations using one-step or two-step self-etch adhesives (1-SEAs or 2-SEAs). In total, 352 restorations of class I-V cavities and non-carious cervical lesions in vital teeth (1-SEAs; 52 cases, 2-SEAs; 300 cases) were placed at nine university hospitals and evaluated according to the modified USPHS criteria at baseline, and after 1, 2, and 3 years. The recall rates were 86.6% (1 year), 80.1% (2 years), and 62.2% (3 years). Two restorations failed due to fracture during the follow-up, and there was no significant difference in survival rates between 1-SEAs (97.6%) and 2-SEAs (99.4%). However, 2-SEAs exhibited significantly lower occurrences of discoloration, marginal discoloration, fracture, and plaque retention. Moreover, the subjects reported a significantly lower postoperative hypersensitivity and higher overall satisfaction at all evaluation periods if 2-SEAs were used. (徳島大学機関リポジトリ) ● Metadata: 116711 (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2020-428 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34024886 ● Search Scopus @ Elsevier (PMID): 34024886 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2020-428 (徳島大学機関リポジトリ: 116711, DOI: 10.4012/dmj.2020-428, PubMed: 34024886)
37.	佐藤健人, Teerapong Mamanee, 千葉彩香, 小林駿, 塩谷頼誓, 秋谷聡, 元山裕太郎, 池田正臣, 高橋真広, 保坂啓一, 中島正俊, 田上順次 : 間接法修復物のシェードがタッチキュアシステムを有するデュアルキュア型レジンセメントの象牙質接着強さに及ぼす影響, 日本歯科保存学雑誌, Vol.64, No.2, 116-124, 2021年. (出版サイトへのリンク) ● Publication site (DOI): 10.11471/shikahozon.64.116 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390569335610074496 ● Search Scopus @ Elsevier (DOI): 10.11471/shikahozon.64.116 (DOI: 10.11471/shikahozon.64.116, CiNii: 1390569335610074496)
38.	Shun Kobayashi, Masatoshi Nakajima, Kiyoka Furusawa, Antonin Tichy, Keiichi Hosaka and Junji Tagami : Color adjustment potential of single-shade resin composite to various-shade human teeth: Effect of structural color phenomenon., Dental Materials Journal, 2021. (要約) than other tested RCs (p<0.05) and its reflection spectrum ranged from blue to red, while a blue peak was observed with R1 and R2, indicating a higher color adjustment potential of OMN. (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2020-364 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33883353 ● Search Scopus @ Elsevier (PMID): 33883353 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2020-364 (DOI: 10.4012/dmj.2020-364, PubMed: 33883353)
39.	Mayu Hasegawa, Antonin Tichy, Keiichi Hosaka, Yusuke Kuno, Masaomi Ikeda, Kosuke Nozaki, Ayaka Chiba, Masatoshi Nakajima and Junji Tagami : Degree of conversion and dentin bond strength of light-cured multi-mode adhesives pretreated or mixed with sulfinate agents., Dental Materials Journal, 2021. (要約) The influence of sulfinate agents applied as a dentin pretreatment or a mixture with multi-mode one-step self-etch adhesives (1-SEAs) on the degree of conversion (DC) and micro-tensile bond strength (μTBS) of light-cured 1-SEAs was investigated. 1-SEAs Clearfil Universal Bond Quick (UBQ) or Scotchbond Universal Adhesive (SBU) were applied to dentin in etch&rinse or self-etch mode using various application strategies: 1) no pretreatment, 2) pretreatment with 90 wt% ethanol, 3) pretreatment with a sulfinate agent Clearfil DC Activator (UDC) or Scotchbond Universal DCA (SDC), or 4) a mixture of UBQ+UDC or SBU+SDC. μTBS was measured after 24 h. Additionally, DC was measured using attenuated total reflectance Fourier-transform infrared spectroscopy. Pretreatment with sulfinate agents resulted in the highest μTBS and DC, significantly improving them especially in etch&rinse mode. The mixture of sulfinate agents with 1-SEAs was less effective. Pretreatment with ethanol significantly improved μTBS in etch&rinse mode but compromised μTBS in self-etch mode. (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2020-346 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33678732 ● Search Scopus @ Elsevier (PMID): 33678732 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2020-346 (DOI: 10.4012/dmj.2020-346, PubMed: 33678732)
40.	Pa Kay Pa Khine, Antonin Tichy, Ahmed Abdou, Keiichi Hosaka, Yasunori Sumi, Junji Tagami and Masatoshi Nakajima : Influence of Silane Pretreatment and Warm Air-Drying on Long-Term Composite Adaptation to Lithium Disilicate Ceramic, Crystals, Vol.11, No.2, 86, 2021. (出版サイトへのリンク) ● Publication site (DOI): 10.3390/cryst11020086 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85099943657 (DOI: 10.3390/cryst11020086, Elsevier: Scopus)
41.	Antonin Tichy, Marek Brabec, Pavel Bradna, Keiichi Hosaka, Ayaka Chiba and Junji Tagami : Influence of central and peripheral dentin on micro-tensile bond strength estimated using a competing risk model., Journal of the Mechanical Behavior of Biomedical Materials, Vol.115, 2020. (要約) The bonding performance of dental adhesives is most frequently evaluated using the micro-tensile bond strength (μTBS) test. Despite lacking evidence, peripheral specimens are often discarded to avoid regional variability. This study, therefore, examined whether μTBS to central and peripheral dentin differed. Dentin surfaces of extracted human molars were bonded with various self-etch adhesives, built up with a resin composite, cut into beams, and stressed in tension. Failure mode was classified as adhesive, cohesive in dentin, or other using scanning electron microscopy. Since cohesive failures in dentin were frequent and could confound μTBS results, the data from central/peripheral dentin were analyzed using a Weibull competing risk (CR) model distinguishing failure modes, and its outcomes were compared to a conventional failure mode non-distinguishing Weibull model. Based on the strength data of cohesively failed specimens, the CR model also estimated the strength of dentin. For comparison, the ultimate tensile strength (UTS) of dentin was measured in both regions. The conventional model suggested that peripheral μTBS was higher than central μTBS. Conversely, the CR model disclosed no significant difference in μTBS between the regions but indicated a higher strength of peripheral dentin. This finding was confirmed by UTS measurements, and further supported by the significantly higher incidence of cohesive failures in central dentin. Therefore, peripheral specimens can be used in the μTBS test as well as central ones, but a CR model should be used for statistical analysis if cohesive failures in dentin are frequent, as the strength of peripheral dentin is higher. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jmbbm.2020.104295 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33412405 ● Search Scopus @ Elsevier (PMID): 33412405 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jmbbm.2020.104295 (DOI: 10.1016/j.jmbbm.2020.104295, PubMed: 33412405)
42.	Waleed Almasabi, Antonin Tichy, Ahmed Abdou, Keiichi Hosaka, Masatoshi Nakajima and Junji Tagami : Effect of water storage and thermocycling on light transmission properties, translucency and refractive index of nanofilled flowable composites., Dental Materials Journal, 2020. (要約) The effect of 1-week water storage and subsequent 10,000 thermal cycles on light transmission properties (straight-line transmission (G0), diffusion (DF), the amount of transmitted light (AV)), translucency parameter (TP) and refractive index (RI) of four nanofilled flowable composites was examined. The composites included Filtek Supreme Ultra Flowable Restorative (FSU), Estelite Flow Quick (EFQ), Estelite Universal Flow, (EUF), and Clearfil Majesty ES Flow (ESF), all of A3 shade. For composites with lower filler load (FSU, EFQ), water storage increased G0, AV and TP, but subsequent thermocycling decreased them. An opposite tendency was found for DF. Materials with higher filler load (EUF, ESF) were not significantly affected by aging conditions. RI of EFQ and EUF containing bisphenol A polyethoxy methacrylate (Bis-MPEPP) increased significantly after thermocycling. Additionally, morphological changes were observed using scanning electron microscopy which revealed cracks within nanocluster fillers and dislocation of particles in FSU and EFQ after thermocycling. (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2020-154 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33361663 ● Search Scopus @ Elsevier (PMID): 33361663 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2020-154 (DOI: 10.4012/dmj.2020-154, PubMed: 33361663)
43.	Vasavat Soontornvatin, Taweesak Prasansuttiporn, Ornnicha Thanatvarakorn, Sumana Jittidecharaks, Keiichi Hosaka, M Richard Foxton and Masatoshi Nakajima : Bond strengths of three-step etch-and-rinse adhesives to silane contaminated dentin., Dental Materials Journal, Vol.40, No.2, 385-392, 2020. (要約) This study aimed to evaluate the effect of silane coupling agent contamination on the microtensile bond strength (µTBS) of 3-step etch-and-rinse adhesives on dentin. Flat occlusal dentin surfaces were prepared and randomly divided into 8 groups (n=20) based on the tested adhesives; Scotchbond Multi-purpose or Optibond FL, with contamination of an experimental silane (2 vol% of 3-m ethacryloxypropyltrimethoxysilane at pH 4.5) before acid-etching, after-etching or after-priming; while the groups without silane contamination served as controls. µTBS data were analyzed by two-way ANOVA and Tukey's HSD tests at a significance level of 0.05. Additional specimens of contaminated dentin were used to analyze changes in the organic molecules by Fourier transform infrared spectroscopy (FTIR). Silane contamination before acid-etching did not significantly change µTBS (p>0.05), but contamination after-etching and after-priming significantly decreased µTBS of both adhesives (p<0.05). Silane contamination had an adverse effect on the dentin bond strength of 3-step etch-and-rinse adhesives especially after-priming. (キーワード) Adhesives / Composite Resins / Dental Bonding / Dental Cements / Dentin / Dentin-Bonding Agents / Materials Testing / Resin Cements / Silanes / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2020-025 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33208575 ● Search Scopus @ Elsevier (PMID): 33208575 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2020-025 (DOI: 10.4012/dmj.2020-025, PubMed: 33208575)
44.	Luz Erick Madrigal, Antonin Tichy, Keiichi Hosaka, Masaomi Ikeda, Masatoshi Nakajima and Junji Tagami : The effect of curing mode of dual-cure resin cements on bonding performance of universal adhesives to enamel, dentin and various restorative materials., Dental Materials Journal, Vol.40, No.2, 446-454, 2020. (要約) The effect of curing mode of dual-cure resin cements on the tensile bond strength (TBS) of universal adhesives to enamel, dentin, zirconia, lithium disilicate ceramics (LDS), feldspathic porcelain (FP), and a Pd-Au alloy was evaluated. The substrates were bonded using Tokuyama Universal Bond (TUB) or Scotchbond Universal Adhesive (SBU), followed by luting with Estecem II (ECII) or Rely-X Ultimate (RXU), respectively, which were used either in light-curing or self-curing mode. The TBS test was performed after 24 h or 5,000 thermal cycles. Light-curing significantly improved the 24-h TBS of TUB/ECII to enamel, dentin and FP, as well as the TBS of SBU/RXU to all substrates except LDS. After thermal cycling, light-curing significantly increased the TBS of both adhesives/cements to dentin, but significant differences between curing modes were seldom observed for other substrates. This suggested that light-curing is essential for the hydrophilic dentin, but self-curing might be sufficient for other substrates. (キーワード) Dental Bonding / Dental Cements / Dental Enamel / Dentin / Dentin-Bonding Agents / Materials Testing / Resin Cements / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2020-077 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33162459 ● Search Scopus @ Elsevier (PMID): 33162459 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2020-077 (DOI: 10.4012/dmj.2020-077, PubMed: 33162459)
45.	Rima Zakzuk Alshahni, Kento Sato, Keiichi Hosaka, Takashi Hatayama, Ayaka Chiba, Richard M. Foxton, Junji Tagami, Yasunori Sumi, Yashushi Shimada and Masatoshi Nakajima : Effect of smear layer deproteinization with enzyme solutions on bonding efficacy of one-step self-etch adhesives, International Journal of Adhesion & Adhesives, Vol.102, No.102672 102672, 2020. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ijadhadh.2020.102672 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85088312054 (DOI: 10.1016/j.ijadhadh.2020.102672, Elsevier: Scopus)
46.	PaPa Kaykhine, Antonin Tichy, Ahmed Abdou, Keiichi Hosaka, M Richard Foxton, Yasunori Sumi, Masatoshi Nakajima and Junji Tagami : Long-term evaluation of warm-air treatment effect on adaptation of silane-containing universal adhesives to lithium disilicate ceramic., Dental Materials Journal, Vol.40, No.2, 379-384, 2020. (要約) The effect of warm air-blowing on the sealing ability of two one-bottle and one two-bottle silane-containing universal adhesives (UAs) applied to lithium disilicate ceramics (LDS) was evaluated. Tapered cavities prefabricated in LDS blocks (IPS e.max CAD) were treated by the adhesives, air-blown either with normal air (23±1°C) or warm air (60±5°C), and filled with a flowable resin composite. Interfacial gap formation was observed using swept-source optical coherence tomography immediately after filling, after 24 h, 5,000 and 10,000 thermal cycles, and an additional 1-year water storage. Specimens bonded using normal air-blown one-bottle UAs exhibited a significantly higher gap formation than the two-bottle UA (p<0.001), and detached within 24 h. Warm air-blowing significantly decreased the gap formation of one-bottle UAs (p<0.001), but the specimens dislocated within 24 h or during thermocycling. The two-bottle UA withstood all aging procedures and warm air-blowing significantly decreased its 1-year gap formation compared to normal air-blowing (p=0.002). (キーワード) Ceramics / Dental Bonding / Dental Cements / Dental Porcelain / Materials Testing / Resin Cements / Silanes / Surface Properties (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2020-057 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33100300 ● Summary page in Scopus @ Elsevier: 2-s2.0-85103682349 (DOI: 10.4012/dmj.2020-057, PubMed: 33100300, Elsevier: Scopus)
47.	Yasushi Shimada, F Michael Burrow, Kazuyuki Araki, Yuan Zhou, Keiichi Hosaka, Alireza Sadr, Masahiro Yoshiyama, Takashi Miyazaki, Yasunori Sumi and Junji Tagami : 3D imaging of proximal caries in posterior teeth using optical coherence tomography., Scientific Reports, Vol.10, No.1, 2020. (要約) Optical coherence tomography (OCT) can create cross-sectional images of tooth without X-ray exposure. This study aimed to investigate the diagnostic accuracy of 3D imaging of OCT for proximal caries in posterior teeth. Thirty-six human molar teeth with 51 proximal surfaces visibly 6 intact, 16 slightly demineralized, and 29 distinct carious changes were mounted to take digital radiographs and 3D OCT images. The sensitivity, specificity and area under the receiver operating characteristic curve (AUC) for the diagnosis of enamel caries and dentin caries were calculated to quantify the diagnostic ability of 3D OCT in comparison with digital radiography. Diagnostic accuracy was evaluated by the agreement with histology using weighted Kappa. OCT showed significantly higher sensitivity, AUC and Kappa values than radiography. OCT can be a safer option for the diagnosis of proximal caries in posterior teeth that can be applied to the patients without X-ray exposure. (キーワード) Dental Caries / Humans / Imaging, Three-Dimensional / Molar / Sensitivity and Specificity / Tomography, Optical Coherence (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-020-72838-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32978464 ● Search Scopus @ Elsevier (PMID): 32978464 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-020-72838-2 (DOI: 10.1038/s41598-020-72838-2, PubMed: 32978464)
48.	Antonin Tichy, Marek Brabec, Pavel Bradna, Keiichi Hosaka and Junji Tagami : A competing risk model for bond strength data analysis., Dental Materials, Vol.36, No.12, 1508-1515, 2020. (要約) Merging all bond-strength data into one dataset irrespective of the failure mode may result in a severe underestimation of bond strength, especially in groups with low incidence of adhesive failures. Bond-strength data analysis using a CR model could provide more accurate estimates of bond strength, and strength estimates for cohesive failures which were apparently independent of bond strength could serve as an internal validity indicator of the CR model. (キーワード) Composite Resins / Data Analysis / Dental Bonding / Dental Cements / Dentin / Dentin-Bonding Agents / Humans / Materials Testing / Resin Cements / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.dental.2020.09.004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32948331 ● Search Scopus @ Elsevier (PMID): 32948331 ● Search Scopus @ Elsevier (DOI): 10.1016/j.dental.2020.09.004 (DOI: 10.1016/j.dental.2020.09.004, PubMed: 32948331)
49.	Lb Diana Borghetti, Roberto Zimmer, F Fernando Portella, G Eduardo Reston, A Celso Klein-Junior, R Daniel Marinowic and Keiichi Hosaka : Effect of preheating on cytotoxicity and physicochemical properties of light-cured calcium-based cements., Acta Odontológica Latinoamericana, Vol.33, No.2, 82-89, 2020. (要約) The aim of this study was to evaluate the degree of conversion, cytotoxicity, solubility and pH of photopolymerizable calciumbased cements submitted to preheating. The degree of conversion was analyzed by Fourier transform infrared, cytotoxicity by the MTT test and solubility through loss of mass. The data were subjected to statistical tests (ANOVA / Tukey's, p<0.05). The photopolymerizable materials showed a low degree of conversion, regardless of preheating. All materials caused a reduction in cell viability at 24 hours and 7 days, with the Dycal (control) being more cytotoxic. Heat had a positive effect on Biocal at 7 days. Dycal is the most soluble material. Heat had no effect on the solubility or pH of the polymerizable materials. It is concluded that photopolymerizable calcium-based cements have a low degree of conversion and are soluble, which results in mild to moderate cytotoxicity. (キーワード) Calcium / Calcium Hydroxide / Cell Survival / Dental Cements / Dental Pulp Capping / Humans / Hydrogen-Ion Concentration / Light-Curing of Dental Adhesives / Photochemical Processes / Polymerization / Pulp Capping and Pulpectomy Agents (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32920609 ● CiNii @ 国立情報学研究所 (CRID): 1010009142333671692 ● Search Scopus @ Elsevier (PMID): 32920609 (PubMed: 32920609, CiNii: 1010009142333671692)
50.	Keiichi Hosaka, Antonin Tichy, Yuichi Hasegawa, Yasuji Motoyama, Manabu Kanazawa, Junji Tagami and Masatoshi Nakajima : Replacing mandibular central incisors with a direct resin-bonded fixed dental prosthesis by using a bilayering composite resin injection technique with a digital workflow: A dental technique., The Journal of Prosthetic Dentistry, Vol.126, No.2, 150-154, 2020. (要約) A straightforward technique is presented for an interim or short-term definitive esthetic replacement of missing anterior teeth requiring no tooth preparation. Composite resins are injected into transparent silicone indices fabricated from 3-dimensional-printed casts of a digital waxing. The dentin core is formed of a durable short fiber-reinforced injectable composite resin and veneered with an enamel-shade composite resin for enhanced esthetics. Besides being noninvasive, this technique is more straightforward than traditional options, reducing chair time while providing an accurate outcome. (キーワード) Composite Resins / Dental Prosthesis / Esthetics, Dental / Humans / Incisor / Workflow (徳島大学機関リポジトリ) ● Metadata: 116703 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.prosdent.2020.05.007 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32800576 ● Search Scopus @ Elsevier (PMID): 32800576 ● Search Scopus @ Elsevier (DOI): 10.1016/j.prosdent.2020.05.007 (徳島大学機関リポジトリ: 116703, DOI: 10.1016/j.prosdent.2020.05.007, PubMed: 32800576)
51.	田代浩史, 保坂啓一, 田上順次 : Tooth Wearによる機能的・審美的障害に対して直接法コンポジットレジン修復を行った1症例, 日本歯科保存学雑誌, Vol.63, No.4, 327-331, 2020年. (要約) <p> 目的 : 近年, 歯科診療における直接法コンポジットレジン修復は, 適用範囲が顕著に拡大しており, さまざまな原因で起こる歯の硬組織の部分的な欠損に対して, 窩洞形成による保持形態付与を必要とせず, 健全歯質を最大限に保存できる修復法である. このように, 現状の歯冠形態に接着操作や充塡操作を経て, 歯質に材料を接着させることで修復が成立するという特徴は, コンポジットレジン直接修復でのみ対応可能な治療計画を提案し, 従来の歯科治療の概念に新たな選択肢を与えている. 酸蝕などの「Tooth Wear」により歯冠形態や咬合が崩壊した症例においても, その程度に応じた接着修復の適用により治療の難易度を低下させることも可能となる. 長期間の生活習慣 (酸性飲料の習慣的摂取・ブラキシズム) の影響により, 臼歯部咬合面の形態変化と咬合高径の低下による機能障害, 前歯部の変色と歯冠長減少による審美障害とを併発した口腔内状況に対し, 健全歯質への切削を最小限にした直接法コンポジットレジン修復により対応し, これまでのところ良好な結果を得ているので報告する.</p><p> 症例 : 48歳男性. 全顎的Tooth Wearによる臼歯部咬合高径の低下がみられ, これによる前歯部の歯冠長減少とエナメル質の不均一な変色による審美障害が認められた. 全顎的な歯周炎はなく, すべての歯に病的な動揺は認められない. 2016年8月より, 上下顎の臼歯部咬合面にそれぞれ1.0mmの厚さで順次フロアブルレジン充塡を行い, 臼歯部で計2.0mmの咬合挙上を行った. 臼歯部咬合面の修復完了後, 2017年3月より, 前歯部へのコンポジットレジンによるダイレクトベニア修復を行った. 形態修正と研磨を行い, メインテナンスと経過観察に移行し, 3カ月に1回程度の間隔で予後の確認を継続している.</p><p> 結果 : 修復完了より1年11カ月経過時点で, 下顎左側第二大臼歯でのコンポジットレジンの部分破折が一度認められたが, 業者指示の接着ステップに従い補修修復にて対応した. 修復完了後3年1カ月経過後の時点において, 良好な予後が確認されている.</p><p> 結論 : 重度Tooth Wearにより臼歯部咬合高径が低下した機能・審美障害に対し, コンポジットレジン修復を活用した臼歯部の咬合再構成とダイレクトベニア修復で対応し, 3年経過後時点で良好な予後を得ることができた.</p> (キーワード) Tooth Wear / 直接法コンポジットレジン修復 / 咬合再構成 / ダイレクトベニア修復 / 補修修復 (出版サイトへのリンク) ● Publication site (DOI): 10.11471/shikahozon.63.327 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390003825209523968 ● Search Scopus @ Elsevier (DOI): 10.11471/shikahozon.63.327 (DOI: 10.11471/shikahozon.63.327, CiNii: 1390003825209523968)
52.	Afonso Celso Klein-Junior, Kathleen Sobieray, Roberto Zimmer, Freitas Fernando Portella, Galia Eduardo Reston, Daniel Marinowic and Keiichi Hosaka : Effect of heat treatment on cytotoxicity and polymerization of universal adhesives., Dental Materials Journal, Vol.39, No.6, 970-975, 2020. (要約) To assess, in vitro, the influence of heat air treatment on cytotoxicity and degree of conversion (DC) of universal self-etch adhesives (Ambar Universal APS, Scotchbond Universal Adhesive, and Tetric N-Bond Universal) in an NIH/3T3 fibroblast cell culture. Samples were divided into three groups: 1) no heat treatment (control), 2) 37°C and 3) 60°C heat treatment before photopolymerization. Cytotoxicity was analyzed by MTT assay and the DC by FTIR. All adhesives heated at 60°C showed reduced cytotoxicity levels when compared with those heated at 37°C. In general, DC of Ambar Universal APS presented the highest DC than Scotchbond Universal Adhesive and Tetric N-Bond Universal, and the hot air treatment do not influence the conversion. Heat treatment at 60°C was able to reduce the cytotoxicity of universal self-etch adhesives, even, the heat treatment does not enhances the DC. (キーワード) Adhesives / Dental Bonding / Dental Cements / Dentin / Dentin-Bonding Agents / Hot Temperature / Materials Testing / Polymerization / Resin Cements (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2019-103 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32611987 ● Search Scopus @ Elsevier (PMID): 32611987 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2019-103 (DOI: 10.4012/dmj.2019-103, PubMed: 32611987)
53.	Keiichi Hosaka, Antonin Tichy, Yasuji Motoyama, Koji Mizutani, Wei-Jen Lai, Zuisei Kanno, Junji Tagami and Masatoshi Nakajima : Post-orthodontic recontouring of anterior teeth using composite injection technique with a digital workflow., Journal of Esthetic And Restorative Dentistry, Vol.32, No.7, 638-644, 2020. (要約) Post-orthodontic recontouring using direct composite restorations is well accepted by patients due to low cost and non-invasiveness. However, in complicated cases, the free-hand technique is time-consuming and technique-sensitive. The presented composite injection technique with a digital workflow significantly simplifies and expedites the composite placement while predictably enhancing the treatment outcome. (キーワード) Composite Resins / Dental Restoration, Permanent / Esthetics, Dental / Humans / Incisor / Workflow (出版サイトへのリンク) ● Publication site (DOI): 10.1111/jerd.12619 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32603555 ● Search Scopus @ Elsevier (PMID): 32603555 ● Search Scopus @ Elsevier (DOI): 10.1111/jerd.12619 (DOI: 10.1111/jerd.12619, PubMed: 32603555)
54.	Kazuhide Yonekura, Keiichi Hosaka, Antonin Tichy, Keita Taguchi, Masaomi Ikeda, Ornnicha Thanatvarakorn, Taweesak Prasansuttiporn, Masatoshi Nakajima and Junji Tagami : Air-blowing strategies for improving the microtensile bond strength of one-step self-etch adhesives to root canal dentin., Dental Materials Journal, Vol.39, No.5, 892-899, 2020. (要約) The effect of different air-blowing strategies using a prototype of a newly developed clinically applicable warm air-blowing device on the microtensile bond strength (μTBS) of one-step self-etch adhesives (1-SEAs) to human root-canal dentin was evaluated. Post cavities (8 mm depth, 1.5 mm diameter) were prepared and bonded with four 1-SEAs. Air-blowing was performed using normal air (23±1°C) for 10 or 20 s; warm air (60±1°C) for 10 or 20 s; or their combination for 10 s (5 s normal, 5 s warm) or 20 s (10 s normal, 10 s warm). After filling with corresponding core materials and 24-h water storage, μTBS test was performed. For three of the 1-SEAs, combined air-blowing for 20 s significantly increased μTBS compared to other air-blowing strategies (p<0.05). This suggests that the combination of normal and warm air-blowing for 20 s can enhance solvent evaporation from 1-SEAs, thus resulting in their improved bonding performance to root-canal dentin. (キーワード) Adhesives / Dental Bonding / Dental Cements / Dental Pulp Cavity / Dentin / Dentin-Bonding Agents / Humans / Materials Testing / Resin Cements / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2019-299 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32448851 ● Search Scopus @ Elsevier (PMID): 32448851 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2019-299 (DOI: 10.4012/dmj.2019-299, PubMed: 32448851)
55.	Taweesak Prasansuttiporn, Ornnicha Thanatvarakorn, Teerapong Mamanee, Keiichi Hosaka, Junji Tagami, Richard M. Foxton and Masatoshi Nakajima : Effect of antioxidant/reducing agents on the initial and long-term bonding performance of a self-etch adhesive to caries-affected dentin with and without smear layer-deproteinizing, International Journal of Adhesion & Adhesives, Vol.102, No.102648 102648, 2020. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ijadhadh.2020.102648 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85084948630 (DOI: 10.1016/j.ijadhadh.2020.102648, Elsevier: Scopus)
56.	Yu Soe Paing, Antonin Tichy, Keiichi Hosaka, Daiki Nagano, Masatoshi Nakajima and Junji Tagami : Effect of smear layer deproteinization with HOCl solution on the dentin bonding of conventional and resin-modified glass-ionomer cements., European Journal of Oral Sciences, Vol.128, No.3, 255-262, 2020. (要約) The effect of smear layer-deproteinizing pretreatment using hypochlorous acid (HOCl) on the micro-shear bond strengths (μSBS) of conventional and resin-modified glass-ionomer cements (GIC) to dentin was investigated and compared with demineralizing pretreatment with polyacrylic acid (PAA). Three GICs: Fuji IX GP Extra (restorative conventional GIC), GC Fuji II LC EM (restorative resin-modified GIC), and GC Fuji Luting EX (luting resin-modified GIC), were used. One hundred fifty human molars were divided into groups (n = 10) according to the cements and dentin pretreatments; no pretreatment (control), 10 s PAA pretreatment, and HOCl pretreatment for 5, 15, or 30 s. After 24 h, μSBS was tested and the data were statistically analyzed using a two-way ANOVA, followed by Tukey's post-hoc test. HOCl pretreatment significantly increased μSBS of conventional GIC compared to the control group. For resin-modified restorative GIC, 5 s HOCl deproteinization significantly increased μSBS, while longer application times did not. There was no significant difference between HOCl-pretreated and control groups of resin-modified luting GIC. PAA pretreatment increased the μSBS of all cements significantly. In conclusion, smear layer deproteinization with HOCl can enhance the dentin bonding of conventional GIC. However, the residual radicals may adversely affect the polymerization of resin-modified GICs. (キーワード) Composite Resins / Dental Bonding / Dentin / Glass Ionomer Cements / Humans / Hypochlorous Acid / Materials Testing / Resin Cements / Smear Layer (出版サイトへのリンク) ● Publication site (DOI): 10.1111/eos.12694 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32311176 ● Search Scopus @ Elsevier (PMID): 32311176 ● Search Scopus @ Elsevier (DOI): 10.1111/eos.12694 (DOI: 10.1111/eos.12694, PubMed: 32311176)
57.	Antonin Tichy, Keiichi Hosaka, Ahmed Abdou, Masatoshi Nakajima and Junji Tagamimi : Degree of Conversion Contributes to Dentin Bonding Durability of Contemporary Universal Adhesives., Operative Dentistry, Vol.45, No.5, 556-566, 2020. (要約) The degree of conversion of contemporary universal adhesives positively correlates with the bond strength to dentin. The correlation is more marked after thermocycling, suggesting that a high degree of conversion is required for long-term dentin bonding durability. Purpose: The objectives of this study were to evaluate the micro-tensile bond strength (μTBS) of five contemporary universal adhesives to dentin after 24 hours and thermocycling (TC), to measure their degrees of conversion (DC) and to test the correlation between μTBS and DC.Methods and Materials: Four commercially available universal adhesives, Prime&Bond universal (PBU), Ecosite Bond (EB), G-Premio Bond (GPB), and Clearfil Universal Bond Quick (UBQ), and one experimental adhesive, UBQ without an amide monomer (UBQ-A), were used in this study. For the μTBS test, midcoronal dentin of 50 human molars was exposed, ground using 600-grit SiC paper, and the adhesives were applied according to the manufacturers' instructions. After resin-composite buildup and 24-hour water storage, one-half of the specimens were subjected to 15,000 thermal cycles. The specimens were sectioned into beams and stressed in tension at a crosshead speed of 1 mm/min until failure. The DC of adhesives applied to dentin was evaluated using attenuated total reflectance Fourier-transform infrared spectroscopy immediately after light-curing. All data were statistically analyzed at a significance level of 0.05.Results: The highest μTBSs were obtained with UBQ, UBQ-A, and PBU, which were not significantly different from each other both after 24 hours and TC. The μTBS of GPB was lower compared with the aforementioned adhesives, but significantly only after TC, and the lowest μTBSs were obtained with EB. TC did not affect the μTBSs of UBQ, UBQ-A, and PBU significantly, but a significant decrease was observed with GPB and EB. The highest DC was obtained with PBU and UBQ, followed by 2-hydroxyethyl methacrylate-rich adhesives UBQ-A and EB, which exhibited significantly lower DCs. The DC of GPB could not be determined because the reference peak at 1608 cm-1 was not detected in its spectra. A significant positive correlation was shown between μTBS and DC after 24 hours (r=0.716) and TC (r=0.856).Conclusion: μTBS and DC were positively correlated, more markedly after TC, which suggests that DC may be an important factor for bond durability. (キーワード) Adhesives / Composite Resins / Dental Bonding / Dental Cements / Dentin / Dentin-Bonding Agents / Humans / Materials Testing / Resin Cements / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.2341/19-165-L (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32243250 ● Summary page in Scopus @ Elsevier: 2-s2.0-85094964106 (DOI: 10.2341/19-165-L, PubMed: 32243250, Elsevier: Scopus)
58.	Celso-Afonso Klein-Junior, Roberto Zimmer, Diana-Lina-Bronca Borghetti, Fernando-Freitas Portella, Flávia-Carolina Abich, Daniel-Rodrigo Marinowic, Keiichi Hosaka and Eduardo-Galia Reston : Hot air stream reduces cytotoxicity of light-cured calcium hydroxide based cements., Journal of Clinical and Experimental Dentistry, Vol.12, No.3, e215-e219, 2020. (要約) Dental pulp capping, dental cements, calcium hydroxide, cell survival. (出版サイトへのリンク) ● Publication site (DOI): 10.4317/jced.56590 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32190190 ● Search Scopus @ Elsevier (PMID): 32190190 ● Search Scopus @ Elsevier (DOI): 10.4317/jced.56590 (DOI: 10.4317/jced.56590, PubMed: 32190190)
59.	關奈央子, 水谷幸嗣, 保坂啓一, 駒田亘, 金澤学, 駒ヶ嶺友梨子, ジャネルモロス, 須永昌代, 川口陽子, 森尾郁子, 木下淳博 : 医歯学総合研究科歯学系大学院生対象の国際歯科臨床教育コース(Essential Expertise for Clinical Dentistry)に対する評価, 口腔病学会雑誌, Vol.87, No.1, 16-17, 2020年.
60.	Citra Kusumasari, Ahmed Abdou, Antonin Tichy, Takashi Hatayama, Keiichi Hosaka, M Richard Foxton, Takahiro Wada, Yasunori Sumi, Masatoshi Nakajima and Junji Tagami : Effect of smear layer deproteinization with chemo-mechanical caries removal agents on sealing performances of self-etch adhesives., Journal of Dentistry, Vol.94, 2020. (要約) Papacarie significantly reduced gap formation with both self-etch adhesives at all locations, compared to the control group (p < 0.05). In contrast, increased gap formation was observed with Carisolv and NaOCl. In most groups, CSE exhibited significantly lower gap formation than GBP (p < 0.05). ATR-FTIR revealed a significant decrease in the amide:phosphate ratio for all the deproteinizing agents (p < 0.05). (キーワード) Adhesives / Animals / Cattle / Composite Resins / Dental Bonding / Dental Cements / Dental Enamel / Dentin / Dentin-Bonding Agents / Materials Testing / Resin Cements / Smear Layer (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jdent.2020.103300 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32070754 ● Search Scopus @ Elsevier (PMID): 32070754 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jdent.2020.103300 (DOI: 10.1016/j.jdent.2020.103300, PubMed: 32070754)
61.	Antonin Tichy, Keiichi Hosaka and Junji Tagami : Universal adhesives - a new direction in the development of adhesive systems, Czech Dental Journal, Vol.120, No.1, 4-12, 2020. (出版サイトへのリンク) ● Publication site (DOI): 10.51479/cspzl.2020.004 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.51479/cspzl.2020.004 (DOI: 10.51479/cspzl.2020.004)
62.	Takashi Hatayama, Yukinori Kano, Asami Aida, Ayaka Chiba, Kento Sato, Naoko Seki, Keiichi Hosaka, M Richard Foxton, Junji Tagami and Masatoshi Nakajima : The combined effect of light-illuminating direction and enamel rod orientation on color adjustment at the enamel borders of composite restorations., Clinical Oral Investigations, Vol.24, No.7, 2305-2313, 2019. (要約) The line-of-vision angle would affect the perception of color adaptation at the enamel borders in the composite restorations. (キーワード) Animals / Cattle / Color / Composite Resins / Dental Enamel / Dental Restoration, Permanent / Light / Resin Cements (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00784-019-03085-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31650317 ● Search Scopus @ Elsevier (PMID): 31650317 ● Search Scopus @ Elsevier (DOI): 10.1007/s00784-019-03085-7 (DOI: 10.1007/s00784-019-03085-7, PubMed: 31650317)
63.	Antonin Tichy, Keiichi Hosaka, Pavel Bradna, Masaomi Ikeda, Ahmed Abdou, Masatoshi Nakajima and Junji Tagami : Subsequent application of bonding agents to a one-step self-etch adhesive - Its effect with/without previous light-curing., Dental Materials, Vol.35, No.12, e299-e309, 2019. (要約) BZF-21 and CSP improved the μTBS of GPB to dentin both immediately and after TC. Higher μTBSs were obtained when GPB remained uncured prior to BA application. (キーワード) Composite Resins / Curing Lights, Dental / Dental Bonding / Dental Cements / Dentin / Dentin-Bonding Agents / Humans / Materials Testing / Resin Cements / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.dental.2019.08.108 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31542248 ● Search Scopus @ Elsevier (PMID): 31542248 ● Search Scopus @ Elsevier (DOI): 10.1016/j.dental.2019.08.108 (DOI: 10.1016/j.dental.2019.08.108, PubMed: 31542248)
64.	Yusuke Kuno, Keiichi Hosaka, Masatoshi Nakajima, Masaomi Ikeda, Afonso Junior Celso Klein, M Richard Foxton and Junji Tagami : Incorporation of a hydrophilic amide monomer into a one-step self-etch adhesive to increase dentin bond strength: Effect of application time., Dental Materials Journal, Vol.38, No.6, 892-899, 2019. (要約) UBQ showed the highest μTBS at 0 s application time among all the adhesives. When the application time was prolonged from 0 s to 10 s, only UBQ showed no significant difference. The hydrophilic amide monomer increased μTBS with reduction in Wsp and increase in the UTS and may allow a shortened application time. (キーワード) Amides / Composite Resins / Dental Bonding / Dental Cements / Dentin / Dentin-Bonding Agents / Materials Testing / Resin Cements / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2018-286 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31366768 ● Search Scopus @ Elsevier (PMID): 31366768 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2018-286 (DOI: 10.4012/dmj.2018-286, PubMed: 31366768)
65.	Nao Kominami, Yasushi Shimada, Keiichi Hosaka, Nguyet Minh Luong, Masahiro Yoshiyama, Alireza Sadr, Yasunori Sumi and Junji Tagami : The effect of flowable composite lining and dentin location on microtensile bond strength and internal fracture formation., Dental Materials Journal, Vol.38, No.5, 798-805, 2019. (要約) The objective of this study was to determine the effect of flowable composite lining and dentin location on internal dentin fracture formation in the microtensile bond strength (MTBS) test using swept-source optical coherence tomography (SS-OCT). MTBS test beams (1.0×1.0 mm) were prepared from human superficial and deep dentin, which was bonded with a self-etch adhesive (Clearfil SE Bond) and hybrid composite resin (Clearfil AP-X), with or without flowable lining (Clearfil Majesty ES-Flow). We tested 4 groups according to placement technique (with vs. without flowable liner) and dentin (superficial vs. deep) locations. Cross-sectional 2D images of the bonded interface were obtained before and after the MTBS test. Internal dentin fracture after MTBT was observed as a bright zone in SS-OCT. Flowable lining significantly reduced internal fracture formation in dentin (p<0.05). Dentin location significantly influenced MTBS (p<0.05), and this was reduced by flowable lining usage. (キーワード) Composite Resins / Cross-Sectional Studies / Dental Bonding / Dental Stress Analysis / Dentin / Dentin-Bonding Agents / Humans / Materials Testing / Resin Cements / Surface Properties / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2018-232 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31341147 ● Search Scopus @ Elsevier (PMID): 31341147 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2018-232 (DOI: 10.4012/dmj.2018-232, PubMed: 31341147)
66.	Kurumi Ide, Masatoshi Nakajima, Juri Hayashi, Keiichi Hosaka, Masaomi Ikeda, Yasushi Shimada, M Richard Foxton, Yasunori Sumi and Junji Tagami : Effect of light-curing time on light-cure/post-cure volumetric polymerization shrinkage and regional ultimate tensile strength at different depths of bulk-fill resin composites., Dental Materials Journal, Vol.38, No.4, 621-629, 2019. (要約) The aim of this study was to investigate volumetric polymerization shrinkage (VS), using swept-source optical coherence tomography (SS-OCT), of bulk-fill composites with different light-curing strategies; immediately after light-irradiation and after 24 h, and to evaluate their regional ultimate tensile strength (UTS) at different curing depths. The immediate VS after photo-polymerization decreased when the curing light-curing time was reduced from 20 to 10 to 5 s. On the other hand, their VS values after 24 h significantly increased due to the post-cure polymerization, resulting in similar VS values at all the light-curing times. Five seconds light-curing decreased the regional UTS of resin composites after the 24 h period compared with the 10 and 20 s light-curing regimes; therefore, the remarkable progress of post-cure polymerization after light-curing for a short time would not lead to an improvement in the mechanical properties of resin composites. The influence of the light-curing time on the curing depth was dependent upon the bulk-fill composite material. (キーワード) Composite Resins / Curing Lights, Dental / Materials Testing / Polymerization / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2018-279 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31178547 ● Search Scopus @ Elsevier (PMID): 31178547 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2018-279 (DOI: 10.4012/dmj.2018-279, PubMed: 31178547)
67.	Keiichi Hosaka, Antonin Tichy, Masaomi Ikeda, Keiichi Nakagawa, Alireza Sadr, Junji Tagami, Masahiro Takahashi, Kento Sato, Yoshihiro Nishitani, Afonso Celso Klein-Junior, H David Pashley and Masatoshi Nakajima : Ultra-high-speed videography of resin-dentin interface failure dynamics under tensile load., Dental Materials, Vol.35, No.7, e153-e161, 2019. (要約) UHS videography enabled visualization of the fracture dynamics at the resin- dentin interfaces under tensile load. However, the resolution at such high frame rate was insufficient to classify the failure mode as precisely as that of SEM. Nevertheless, UHS videography can provide more detailed information about the fracture origin and propagation. (キーワード) Composite Resins / Dental Bonding / Dentin / Dentin-Bonding Agents / Humans / Materials Testing / Microscopy, Electron, Scanning / Resin Cements / Stress, Mechanical / Surface Properties / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.dental.2019.04.006 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31078308 ● Search Scopus @ Elsevier (PMID): 31078308 ● Search Scopus @ Elsevier (DOI): 10.1016/j.dental.2019.04.006 (DOI: 10.1016/j.dental.2019.04.006, PubMed: 31078308)
68.	保坂啓一, 田代浩史, 高橋真広, 岸川隆蔵, 中島正俊, 大槻昌幸, 田上順次 : 大臼歯部1歯欠損症例にフロアブルコンポジットレジンのみを用いた単純化した術式によりダイレクトブリッジ修復を行った1症例, 日本歯科保存学雑誌, Vol.62, No.1, 47-53, 2019年. (要約) <p> 目的 : 接着歯学の発展に伴い, Minimal Intervention Dentistryのコンセプトに基づく歯質接着システムとコンポジットレジンを用いた直接法接着修復治療は, 臨床的有効性と経済的効率性の観点から, 典型的な窩洞のみならず, 空隙歯列の空隙閉鎖, 歯冠形態の改善, 前歯部少数歯欠損補綴までさまざまな症例に多く用いられている. 少数歯欠損補綴に関しては, コンポジットレジンのみで修復する方法は強度が不足することから, より高い強度と破折抵抗性を求めて, ファイバー繊維がしばしば併用されてきた. しかし術式は単純ではなく, 高度な技術が必要である. 近年, 接着性レジンの接着性能やフロアブルコンポジットレジンの物性が向上したことから, 術式がシンプルなコンポジットレジンのみの修復が改めて見直されている. しかし, その報告はあまり多くない. 今回, 大臼歯部1歯欠損補綴に対して最新の接着システムとフロアブルコンポジットレジンのみを用いたダイレクトブリッジ修復を行い, これまでのところ良好な結果を得ているので報告する.</p><p> 症例 : 29歳女性. 下顎左側第一大臼歯は歯根破折の診断により抜歯された. 欠損隣接歯には全周に2, 3mm程度のポケットが観察されたのみで, 全顎的な歯周炎はなく, すべての歯に病的な動揺は認められなかった. また, 矯正歯科治療後の患者で咬合に問題は認められなかった. あらかじめ, 作業用模型上欠損部にポンティックのワックスアップを行い, ポンティック部の咬合面・基底面のシリコンコアを作成した. 2018年2月, 欠損側エナメル質には, リン酸ジェルを用いて酸処理を行った後, ツーステップセルフエッチングシステムを用いてメーカー指示どおり歯面処理を行い, フロアブルコンポジットレジンのみを用いて積層充塡を行いながらダイレクトブリッジ構造を構築した. 咬合調整および形態修正研磨を行い, 1週間後に予後を確認した.</p><p> 結果 : 9カ月経過後の時点においても, 良好な予後が確認されている.</p><p> 結論 : 本症例では, フロアブルコンポジットレジンのみを用いた直接法修復によって大臼歯部1歯欠損補綴治療を完了し良好な予後を得た. ファイバー繊維による補強構造を必要とせず, フロアブルコンポジットレジンのみの修復により良好な予後が得られたことから, 単純化された術式によるダイレクトブリッジ修復の臨床応用が今後期待される.</p> (キーワード) シンプリファイドダイレクトブリッジ修復 / フロアブルコンポジットレジン / セルフエッチングシステム (出版サイトへのリンク) ● Publication site (DOI): 10.11471/shikahozon.62.47 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282763101338112 ● Search Scopus @ Elsevier (DOI): 10.11471/shikahozon.62.47 (DOI: 10.11471/shikahozon.62.47, CiNii: 1390282763101338112)
69.	保坂啓一, 高橋真広, 西谷佳浩, 池田正臣, 中島正俊, 田上順次, 米倉和秀, 田口啓太, アントニーンティヒー, 久野裕介, 永野大樹, 荒岡大輔, 畑山貴志, 佐藤健人 : タッチキュアがセルフエッチシステムの深部根管壁象牙質接着性能に及ぼす効果, 日本歯科保存学雑誌, Vol.62, No.1, 39-46, 2019年. (要約) <p> 目的 : 近年, 生活歯のみならず根管処置歯に対しても接着性コンポジットレジンを用いた直接法支台築造法が行われる機会が増加している. ポスト窩洞における根管壁象牙質への接着では, 窩底部は照射光エネルギーが十分に到達しにくいことから, これまでデュアルキュア型接着システムおよびデュアルキュア型コンポジットレジンが多く用いられてきた. 現在では, デュアルキュア型コンポジットレジンとの間のタッチキュア (接触重合) によって, ボンドへの光照射が困難な部位に関しても重合性の向上を目指すシステムが紹介されている. 本研究では, タッチキュアがセルフエッチシステムの根管壁象牙質への接着性能に及ぼす効果を検討した.</p><p> 材料と方法 : ヒト抜去下顎小臼歯12本に径1.5mm, 深さ8mmのポスト窩洞を形成した後, 1ステップセルフエッチシステム, クリアフィルユニバーサルボンドQuickER (UBQ, クラレノリタケデンタル) および2ステップセルフエッチシステム, クリアフィルメガボンド2 (SE2, クラレノリタケデンタル) を用いて業者指示どおり接着処理を行った. SE2のボンドについては, デュアルキュア型コンポジットレジンとの間でタッチキュアを促進するクリアフィルDCアクティベーター (DCA, クラレノリタケデンタル) との等量混和の有無によって2群を設定した. ボンドへの光照射は, LED光照射器を用いて業者指示どおりそれぞれ10秒間行った. その後, クリアフィルDCコアオートミックスONEを充塡し, LED光照射器を使用して20秒間光照射を行った. 各接着システムについて, 根管接着試料は37°C水中に24時間保管後, 歯根軸に対し直角方向に棒状試片 (断面0.6×0.6mm) を32本作製し, 1窩洞の棒状試片を均等に分け, 合計16本の歯冠側群と根尖側群を設定した. その後, クロスヘッドスピード1mm/minにて微小引張り接着試験を行った. 得られた結果は歯冠側および根尖側, 4試料ずつ分類し, 2-way ANOVAおよびBonferroni補正を用いた<i>t</i>検定を用いて有意水準5%にて統計処理を行った.</p><p> 結果 : すべての群において, 根尖側の接着強さは歯冠側の接着強さより有意に低い値を示した. 歯冠側では, SE2+DCA群はUBQ群より有意に高い値を示したものの, SE2+DCA群とSE2群間, SE2群とUBQ群間の間には有意差は認められなかった. 一方, 根尖側ではすべての材料間に有意差は認められなかった. 根尖側における破断面の観察から, UBQ群, SE2+DCA群におけるBlister Formationが認められた.</p><p> 結論 : 1ステップセルフエッチシステム, 2ステップセルフエッチシステムともに深部根管壁象牙質では接着強さが減少し, タッチキュアの付与による接着性能向上効果は認められなかった. 溶媒が残存しやすく, 照射光の到達しにくいポスト窩洞深部の重合性の改善に関する課題が示唆された.</p> (キーワード) 根管象牙質 / セルフエッチシステム / タッチキュア / 微小引張り接着強さ試験 (出版サイトへのリンク) ● Publication site (DOI): 10.11471/shikahozon.62.39 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282763101655552 ● Search Scopus @ Elsevier (DOI): 10.11471/shikahozon.62.39 (DOI: 10.11471/shikahozon.62.39, CiNii: 1390282763101655552)
70.	Shigeki Uchinuma, Yasushi Shimada, Khairul Matin, Keiichi Hosaka, Masahiro Yoshiyama, Yasunori Sumi and Junji Tagami : Effects of UVB and UVC irradiation on cariogenic bacteria in vitro., Lasers in Medical Science, Vol.34, No.5, 981-989, 2018. (要約) ) were also taken after irradiation. In addition, the bactericidal effects of irradiation against S. mutans under 0.5 mm-thick dentin were compared using culture tests and OD (キーワード) Colony Count, Microbial / Dental Caries / Dentin / Humans / Microbial Viability / Streptococcus mutans / Streptococcus sobrinus / Ultraviolet Rays (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10103-018-2685-4 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30448940 ● Summary page in Scopus @ Elsevier: 2-s2.0-85056856668 (DOI: 10.1007/s10103-018-2685-4, PubMed: 30448940, Elsevier: Scopus)
71.	Dhaifallah Alqarni, Masatoshi Nakajima, Keiichi Hosaka, Kurumi Ide, Daiki Nagano, Takehiro Wada, Masaomi Ikeda, Teerapong Mamanee, Ornnicha Thanatvarakorn, Taweesak Prasansuttiporn, Richard Foxton and Junji Tagami : The repair bond strength to resin matrix in cured resin composites after water aging., Dental Materials Journal, Vol.38, No.2, 233-240, 2018. (要約) The repair microshear bond strengths (µSBSs) to resin matrices in 4 different cured-composites after water storage (0, 60 s, 1 week, 1 month) were evaluated. Three different adhesive application methods to the cured-composites were performed; (1) none, (2) onestep self-etch adhesive application, and (3) one-step self-etch adhesive application with a silane coupling agent. Degree of conversion (DC) of the composite discs was determined using ATR/FT-IR with a time-based spectrum analysis. Initially, the amount of un-reacted resin monomers in the repaired cured-composite contributed to the bonding performance of newly-filled uncured-composite to resin matrix of the cured-composite. Adhesive application could not improve their repair µSBS. After 1-month of water-storage, the repair µSBS was dependent on material, which either reduced or did not and was not influenced by their amount of un-reacted resin monomers. When repairing aged composite resin, the appropriate adhesive application procedures were different among resin composites. (キーワード) Composite Resins / Dental Bonding / Materials Testing / Resin Cements / Spectroscopy, Fourier Transform Infrared / Surface Properties / Tensile Strength / Water (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2018-044 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30449829 ● Search Scopus @ Elsevier (PMID): 30449829 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2018-044 (DOI: 10.4012/dmj.2018-044, PubMed: 30449829)
72.	Seki Naoko, Kanazawa Manabu, Komagamine Yuriko, Mizutani Koji, Keiichi Hosaka, Komoda Wataru, Moross Janelle, Kuroda Shinji, Sunaga Masayo, Kawaguchi Yoko, Morio Ikuko and Kinoshita Atsuhiro : International Dental Education Course for Clinical Expertise at Tokyo Medical and Dental University Graduate School, Journal of Medical and Dental Sciences, Vol.65, No.3, 123-130, 2018. (出版サイトへのリンク) ● Publication site (DOI): 10.11480/jmds.650302 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85061102683 (DOI: 10.11480/jmds.650302, Elsevier: Scopus)
73.	Keiichi Hosaka, Prasansuttiporn Taweesak, Thanatvarakorn Ornnicha, Kunawarote Sitthikorn, Takahashi Masahiro, Foxton M Richard, Tagami Junji and Nakajima Masatoshi : Smear layer-deproteinization: Improving the adhesion of self-etch adhesive systems to caries-affected dentin, Current Oral Health Reports, Vol.5, No.3, 169-177, 2018. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s40496-018-0185-z (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85079859715 (DOI: 10.1007/s40496-018-0185-z, Elsevier: Scopus)
74.	Makwitz Kerber Vieira Francine, Junior Afonso Klein Celso, Reston Galia Eduardo, Santos Beraldo dos Rubem, Portella Freitas Fernando and Keiichi Hosaka : Storage Temperature Influences the Carbamide Peroxide Concentration of at Home Bleaching Agents, Biomedical Journal of Scientific & Technical Research, Vol.9, No.1, 2018. (出版サイトへのリンク) ● Publication site (DOI): 10.26717/BJSTR.2018.09.001750 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.26717/BJSTR.2018.09.001750 (DOI: 10.26717/BJSTR.2018.09.001750)
75.	Daisuke Araoka, Keiichi Hosaka, Masatoshi Nakajima, Richard Foxton, Ornnicha Thanatvarakorn, Taweesak Prasansuttiporn, Ayaka Chiba, Kento Sato, Masahiro Takahashi, Masayuki Otsuki and Junji Tagami : The strategies used for curing universal adhesives affect the micro-bond strength of resin cement used to lute indirect resin composites to human dentin., Dental Materials Journal, Vol.37, No.3, 506-514, 2018. (要約) We evaluated the effect of different curing strategies for universal adhesives on micro-tensile bond strength (μTBS) between resin cement and dentin and/or between resin cement and indirect resin composite. Flat coronal dentin surfaces and composite resin disks were pretreated with silane-containing universal adhesives, with or without light-curing on the dentin-side and/or composite resin disk-side. Resin disks were luted onto the pretreated dentin surfaces with the corresponding dual-cure adhesive resin cements and light-cured, and cut into beams after 24-h water storage. After 0 or 10,000 thermocycles (5ºC/55ºC) in a water bath, the μTBS of the composite resin disk-dentin beam was tested. The μTBS was highest when universal adhesives were applied to both the dentin- and the indirect composite resin disk-side, followed by light-curing. Thermocycling decreased μTBS in all but the Scotchbond Universaltreated group, with light-curing on both sides. The effect of curing strategies is dependent upon the materials. (キーワード) Acrylic Resins / Composite Resins / Dental Bonding / Dental Restoration, Permanent / Dental Stress Analysis / Dentin-Bonding Agents / Humans / In Vitro Techniques / Light-Curing of Dental Adhesives / Materials Testing / Polyurethanes / Resin Cements / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2017-240 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29491200 ● Search Scopus @ Elsevier (PMID): 29491200 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2017-240 (DOI: 10.4012/dmj.2017-240, PubMed: 29491200)
76.	Takashi Hatayama, Ayaka Chiba, Kimisuke Kainose, Masatoshi Nakajima, Keiichi Hosaka, Noriyuki Wakabayashi, M Richard Foxton and Junji Tagami : Stress distribution in tooth resin core build-ups with different post-end positions in alveolar bone level under two kinds of load directions., Dental Materials Journal, Vol.37, No.3, 474-483, 2018. (要約) This study aimed to evaluate influence of different post-end positions in alveolar bone level on stress distributions in resin-core build-up tooth under different load directions. Three-dimensional mathematical models of a root-filled mandibular premolar tooth were constructed. Resin post and core were built-up with six post lengths: 0, 1, 2, 3, 4, and 6 mm. Finite element analysis calculated stress distributions with oblique load of 400 N to buccal cusp 45 degree from buccal side or from lingual side. The 3 mm-post length (post-end position equal to cancellous bone level) caused highest equivalent stress of post-end compared with the shorter or longer post length. When change of load direction, the direction of maximum shear stress became completely opposite at mesiodistal cervical edge of core-part without a change of the magnitude. Changing shear stress direction would increase risk of debonding at mesiodistal cervical edge. (キーワード) Alveolar Process / Bicuspid / Composite Resins / Dental Pulp Cavity / Dental Stress Analysis / Finite Element Analysis / Mandible / Models, Statistical / Post and Core Technique / Root Canal Filling Materials / Stress, Mechanical / Tooth, Nonvital (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2017-160 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29415970 ● Search Scopus @ Elsevier (PMID): 29415970 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2017-160 (DOI: 10.4012/dmj.2017-160, PubMed: 29415970)
77.	Keita Taguchi, Keiichi Hosaka, Masaomi Ikeda, Ryuzo Kishikawa, Richard Foxton, Masatoshi Nakajima and Junji Tagami : The effect of warm air-blowing on the microtensile bond strength of one-step self-etch adhesives to root canal dentin., Journal of Prosthodontic Research, Vol.62, No.3, 330-336, 2018. (要約) The μTBS of 1-SEAs to root canal dentin was improved by using warm air-blowing. (キーワード) Air / Air Movements / Dental Bonding / Dental Cements / Dental Etching / Dental Pulp Cavity / Dentin / Humans / Solvents / Temperature / Tensile Strength / Volatilization (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jpor.2017.12.006 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29397352 ● Search Scopus @ Elsevier (PMID): 29397352 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jpor.2017.12.006 (DOI: 10.1016/j.jpor.2017.12.006, PubMed: 29397352)
78.	Daiki Nagano, Masatoshi Nakajima, Masahiro Takahashi, Masaomi Ikeda, Keiichi Hosaka, Kento Sato, Taweesak Prasansuttiporn, M Richard Foxton and Junji Tagami : Effect of Water Aging of Adherend Composite on Repair Bond Strength of Nanofilled Composites., The Journal of Adhesive Dentistry, Vol.20, No.5, 425-433, 2018. (要約) Microhybrid composite was a more suitable material for composite repair than nanofilled composite, due to adhesion to exposed, larger silica fillers. S-PRG filler and nanocluster filler in the nanofilled composites played a slight role in improving their repair bonding performances with the bonding agents tested. (キーワード) Bisphenol A-Glycidyl Methacrylate / Composite Resins / Dental Bonding / Dental Materials / Dental Polishing / Light-Curing of Dental Adhesives / Materials Testing / Resin Cements / Shear Strength / Surface Properties / Time Factors / Water (出版サイトへのリンク) ● Publication site (DOI): 10.3290/j.jad.a41331 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30375582 ● Search Scopus @ Elsevier (PMID): 30375582 ● Search Scopus @ Elsevier (DOI): 10.3290/j.jad.a41331 (DOI: 10.3290/j.jad.a41331, PubMed: 30375582)
79.	N Rutthanu Wongsorachai, Ornnicha Thanatvarakorn, Taweesak Prasansuttiporn, Sumana Jittidecharaks, Keiichi Hosaka, M Richard Foxton and Masatoshi Nakajima : Effect of Polymerization Accelerator on Bond Strength to Eugenol-Contaminated Dentin., The Journal of Adhesive Dentistry, Vol.20, No.6, 541-547, 2018. (要約) The application of a polymerization accelerator on eugenol-contaminated dentin prior to adhesive resin application increased the μTBS of both the three-step etch-and-rinse and two-step self-etch adhesive. (キーワード) Acid Etching, Dental / Curing Lights, Dental / Dental Bonding / Dental Cements / Dentin / Eugenol / Humans / Polymerization / Tensile Strength / Toluene (出版サイトへのリンク) ● Publication site (DOI): 10.3290/j.jad.a41631 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30564801 ● Search Scopus @ Elsevier (PMID): 30564801 ● Search Scopus @ Elsevier (DOI): 10.3290/j.jad.a41631 (DOI: 10.3290/j.jad.a41631, PubMed: 30564801)
80.	Ornnicha Thanatvarakorn, Taweesak Prasansuttiporn, Suppason Thittaweerat, M Richard Foxton, Shizuko Ichinose, Junji Tagami, Keiichi Hosaka and Masatoshi Nakajima : Smear layer-deproteinizing improves bonding of one-step self-etch adhesives to dentin., Dental Materials, Vol.34, No.3, 434-441, 2017. (要約) application could enhance the quality of dentin for bonding to one-step self-etch adhesives, resulting in the improving μTBS, eliminating hybridized smear layer and preventing reticular nanoleakage formation in resin-dentin bonding interface. (キーワード) Composite Resins / Dental Bonding / Dental Leakage / Dentin / Dentin-Bonding Agents / Humans / Hypochlorous Acid / In Vitro Techniques / Materials Testing / Microscopy, Electron, Transmission / Resin Cements / Smear Layer / Surface Properties / Tensile Strength / Toluene (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.dental.2017.11.023 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29233540 ● Search Scopus @ Elsevier (PMID): 29233540 ● Search Scopus @ Elsevier (DOI): 10.1016/j.dental.2017.11.023 (DOI: 10.1016/j.dental.2017.11.023, PubMed: 29233540)
81.	Yukari Noda, Masatoshi Nakajima, Masahiro Takahashi, Teerapong Mamanee, Keiichi Hosaka, Tomohiro Takagaki, Masaomi Ikeda, M Richard Foxton and Junji Tagami : The effect of five kinds of surface treatment agents on the bond strength to various ceramics with thermocycle aging., Dental Materials Journal, Vol.36, No.6, 755-761, 2017. (要約) This study evaluated the effects of ceramic surface treatment agents on shear bond strengths to ceramic materials with and without thermocycling. Ceramic plates were prepared from feldspathic ceramic; AAA, lithium disilicate ceramic material; IPS e.max Press, zirconia ceramic; Lava. Ceramic surfaces were pretreated with one of five surface treatment agents (Clearfil PhotoBond mixed with Porcelainbond activator (PB), Clearfil SE One mixed with Porcelainbond activator (SO), Ceramic Primer (CP), Universal Primer (UP), Scotchbond Universal (SU)), and then a resin cement (Clapearl DC) was filled. After 0, 5,000, and 10,000 thermocycles, micro-shear bond strengths between ceramic-cement interfaces were determined. SU exhibited significantly lower initial bond strength to AAA and e.max than PB, SO, CP, and UP. For Lava, PB, SO, CP and SU exhibited higher initial bond strengths than UP. Thermocycles reduced bond strengths to all the ceramic materials with any surface treatment. (キーワード) Ceramics / Cold Temperature / Dental Bonding / Dental Cements / Dental Porcelain / Dental Restoration Failure / Dentin-Bonding Agents / Hot Temperature / Materials Testing / Resin Cements / Shear Strength / Surface Properties / Time Factors (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2016-383 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28701640 ● Summary page in Scopus @ Elsevier: 2-s2.0-85037548772 (DOI: 10.4012/dmj.2016-383, PubMed: 28701640, Elsevier: Scopus)
82.	Kento Sato, Keiichi Hosaka, Masahiro Takahashi, Masaomi Ikeda, Fucong Tian, Wataru Komada, Masatoshi Nakajima, Richard Foxton, Yoshihiro Nishitani, H David Pashley and Junji Tagami : Dentin Bonding Durability of Two-step Self-etch Adhesives with Improved of Degree of Conversion of Adhesive Resins., The Journal of Adhesive Dentistry, Vol.19, No.1, 31-37, 2017. (要約) CSE2 showed significantly higher DC than CSE. The µTBS of CSE2 was significantly higher than that of CSE in all water storage periods. One-year water storage decreased the µTBS of CSE; however, it did not decrease that of CSE2. Regarding the polymerized adhesive resins, the elastic modulus of CSE2 was significantly higher than that of CSE before and after water immersion (p < 0.001), and the water sorption of CSE was higher than that of CSE2. (キーワード) Adhesiveness / Dental Bonding / Dental Etching / Dentin-Bonding Agents / Materials Testing / Resin Cements (出版サイトへのリンク) ● Publication site (DOI): 10.3290/j.jad.a37726 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28195277 ● Summary page in Scopus @ Elsevier: 2-s2.0-85014508514 (DOI: 10.3290/j.jad.a37726, PubMed: 28195277, Elsevier: Scopus)
83.	Wataru Komada, Tasuku Inagaki, Yoji Ueda, Satoshi Omori, Keiichi Hosaka, Junji Tagami and Hiroyuki Miura : Influence of water immersion on the mechanical properties of fiber posts., Journal of Prosthodontic Research, Vol.61, No.1, 73-80, 2016. (要約) The prefabricated glass fiber posts and structures using resin composites with glass fiber posts were affected by water immersion. (キーワード) Composite Resins / Dental Materials / Glass / Immersion / Materials Testing / Stress, Mechanical / Tensile Strength / Time Factors / Water (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jpor.2016.05.005 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27324293 ● Summary page in Scopus @ Elsevier: 2-s2.0-85008412657 (DOI: 10.1016/j.jpor.2016.05.005, PubMed: 27324293, Elsevier: Scopus)
84.	保坂啓一, 高橋真広, 中島正俊, 大槻昌幸, 田上順次 : 矯正歯科治療後のコンポジットレジン再修復の長期予後報告, 歯科審美, Vol.28, No.2, 57-63, 2016年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1010000782306381443 (CiNii: 1010000782306381443)
85.	保坂啓一, 高橋真広, 中島正俊, 田上順次 : 【歯質に対する接着耐久性を考える】ボンディング材の劣化が接着耐久性に及ぼす影響, 日本歯科理工学会誌, Vol.32, No.4, 269-272, 2013年.
86.	Yoshihiro Nishitani, Keiichi Hosaka, Tomohiro Hoshika, Masahiro Yoshiyama and H David Pashley : Effects of chlorhexidine in self-etching adhesive: 24 hours results., Dental Materials Journal, Vol.32, No.3, 420-424, 2013. (要約) It is known that chlorhexidine (CHX) does not inhibit micro-tensile bond strengths (MTBS) when it is used in etch-and-rinse adhesives. In that technique, CHX is applied to dentin as a primer after phosphoric acid-etching before bonding with Single Bond. It would be more convenient if it is possible to incorporate CHX into the adhesive. The purpose of this study was to compare the MTBS and the FT-IR percent conversion of an all-in-one self-etching adhesives contained varying concentration of CHX. Extracted human third molars were bonded with a control all-in-one adhesive or experimental versions containing 0.5, 1, 2 or 5% CHX. The MTBS and the percent conversion of experimental adhesives containing up to 1% CHX were not significantly CHX-free control adhesives. However, addition of 2 or especially 5% CHX experimental adhesives produced significant reductions in both the MTBS and the percent conversion. (キーワード) Analysis of Variance / Anti-Infective Agents, Local / Chlorhexidine / Dental Bonding / Dental Etching / Dental Restoration Failure / Dental Stress Analysis / Dentin / Dentin-Bonding Agents / Humans / Materials Testing / Polymerization / Resin Cements / Spectroscopy, Fourier Transform Infrared / Statistics, Nonparametric / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2012-199 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23719003 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878445707 (DOI: 10.4012/dmj.2012-199, PubMed: 23719003, Elsevier: Scopus)
87.	Mako Tsubone, Masatoshi Nakajima, Keiichi Hosaka, M Richard Foxton and Junji Tagami : Color shifting at the border of resin composite restorations in human tooth cavity., Dental Materials, Vol.28, No.8, 811-817, 2012. (要約) All resin composite restorations in the tooth cavities produced the color shifting of resin composite and tooth at the border. For deep cavity, resin composites with higher diffused light transmission property showed higher color shifting at the border, while for shallow cavity, the straight-line as well as diffused light transmission of resin composite affected the color shifting at the border. Clinically, diffused light transmission property of resin composites may contribute to the color shifting at the border of resin composite restoration regardless of cavity depth, resulting in better color matching. (キーワード) Analysis of Variance / Bicuspid / Color / Colorimetry / Composite Resins / Dental Cavity Preparation / Dental Restoration, Permanent / Humans / Photochemical Processes / Spectrophotometry (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.dental.2012.04.032 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22607763 ● Summary page in Scopus @ Elsevier: 2-s2.0-84863775434 (DOI: 10.1016/j.dental.2012.04.032, PubMed: 22607763, Elsevier: Scopus)
88.	Tomoyuki Takai, Keiichi Hosaka, Keisuke Kambara, Suppason Thitthaweerat, Naoko Matsui, Masahiro Takahashi, Ryuzo Kishikawa, Masatoshi Nakajima, Masayuki Otsuki, M Richard Foxton and Junji Tagami : Effect of air-drying dentin surfaces on dentin bond strength of a solvent-free one-step adhesive., Dental Materials Journal, Vol.31, No.4, 558-563, 2012. (要約) The purpose was to evaluate the effect of air-drying dentin surfaces on the microtensile bond strength (μTBS) of a solvent-free onestep adhesive (Bond 1 SF). Twelve human molars were ground with 600-grit SiC paper. Before applying bonding agent, the dentin surface was rinsed with distilled water and blot-dried with tissue paper, followed by air-drying for 0, 3, 30, and 60 s using with a dental air syringe. After applying and curing Bond 1 SF, resin composite was incrementally built up. Specimens were then stored in distilled water for 24 h and then μTBSs were measured at a cross-head speed of 1 mm/min. Higher μTBS were observed when the dentin surface was air-dried for 3 s (33.2±6.8MPa)>0 s (26.7±4.5MPa)>30 s (22.6±5.5MPa)=60 s (20.4±5.0MPa). The results suggested that prolonged air-drying of the dentin surface removed water and decreased the bond strengths of Bond 1 SF. (キーワード) Air / Analysis of Variance / Dental Bonding / Dental Etching / Dental Stress Analysis / Dentin / Dentin-Bonding Agents / Desiccation / Humans / Methacrylates / Molar / Resin Cements / Surface Properties / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2012-034 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22864208 ● Summary page in Scopus @ Elsevier: 2-s2.0-84864716807 (DOI: 10.4012/dmj.2012-034, PubMed: 22864208, Elsevier: Scopus)
89.	Keisuke Kambara, Masatoshi Nakajima, Keiichi Hosaka, Masahiro Takahashi, Ornnicha Thanatvarakorn, Shizuko Ichinose, M Richard Foxton and Junji Tagami : Effect of smear layer treatment on dentin bond of self-adhesive cements., Dental Materials Journal, Vol.31, No.6, 980-987, 2012. (要約) The purpose of this study was to compare the dentin bond strength of three self-adhesive cements with smear layer pretreatments using a calcium-chelating agent (EDTA) and deproteinizing solution (NaOCl) and to evaluate their interfacial characteristics. Smear layer-covered dentin surfaces were pretreated with EDTA for 60 s, NaOCl for 5 and 15 s, or none. Three self-adhesive cements; Clearfil SA luting (Kuraray Medical), Rely X Unicem clicker (3M ESPE) and Breeze (Pentron) were applied to the dentin surfaces. After 24-h water storage, shear bond strengths to dentin were determined. In addition, nanoleakage evaluation at the interface was performed using FE-SEM and EDS. EDTA-pretreatment significantly improved the bond strength of BR (p<0.05) and NaOCl-pretreatment for 15 s significantly improved the bond strength of RX (p<0.05). On the other hand, for SA, both pretreatments significantly decreased bond strength to dentin (p<0.05). Nanoleakage formation was observed in various amounts at the cement-dentin interfaces. (キーワード) Dental Bonding / Dental Cavity Preparation / Dental Leakage / Dental Stress Analysis / Dentin-Bonding Agents / Edetic Acid / Humans / Resin Cements / Shear Strength / Smear Layer / Sodium Hypochlorite (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2012-031 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23207204 ● Summary page in Scopus @ Elsevier: 2-s2.0-84871109798 (DOI: 10.4012/dmj.2012-031, PubMed: 23207204, Elsevier: Scopus)
90.	Kanako Horie, Masatoshi Nakajima, Keiichi Hosaka, Kimisuke Kainose, Azusa Tanaka, M Richard Foxton and Junji Tagami : Influences of composite-composite join on light transmission characteristics of layered resin composites., Dental Materials, Vol.28, No.2, 204-211, 2011. (要約) Resin composite placed in layers exhibited reduced straight-line light transmission and increased diffusion transmission compared with bulk-filled resin composite. The layering technique affected the translucency and color rendition of resin composite. (キーワード) Barium Compounds / Bisphenol A-Glycidyl Methacrylate / Chemical Phenomena / Color / Composite Resins / Dental Bonding / Dental Materials / Humans / Light / Materials Testing / Microscopy, Electron, Scanning / Optical Phenomena / Photometry / Polyethylene Glycols / Polymethacrylic Acids / Silicon Dioxide / Spectrophotometry (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.dental.2011.10.006 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22056733 ● Summary page in Scopus @ Elsevier: 2-s2.0-84855781988 (DOI: 10.1016/j.dental.2011.10.006, PubMed: 22056733, Elsevier: Scopus)
91.	Yuko Shinoda, Masatoshi Nakajima, Keiichi Hosaka, Masayuki Otsuki, M Richard Foxton and Junji Tagami : Effect of smear layer characteristics on dentin bonding durability of HEMA-free and HEMA-containing one-step self-etch adhesives., Dental Materials Journal, Vol.30, No.4, 501-510, 2011. (要約) The purpose of this study was to evaluate the effect of smear layer characteristics on the dentin bonding durability of HEMA-free and HEMA-containing one-step self-etch adhesives. Xeno V (XV; HEMA-free), G BOND PLUS (GB; HEMA-free) and Clearfil S(3 )Bond (S(3); HEMA-containing), were applied to dentin surfaces prepared with either #180- or #600-grit SiC paper according to manufacturers' instructions. Bond strengths to dentin were determined using µTBS test after 24-hour, 6-month, and 1-year water storage. In addition, nanoleakage evaluation was performed using an SEM. The smear layer characteristics affected water-tree nanoleakage formation in the adhesive layers of XV and GB, which contributed to a reduction in µTBS after 6-month water storage, while the characteristics did not affect the µTBS of S(3). However, regardless of the smear layer characteristics, 1-year water storage significantly reduced the µTBS of all the adhesives and was associated with an increase in failures at the adhesive-composite interface. (キーワード) Adhesiveness / Carbon Compounds, Inorganic / Dental Bonding / Dental Leakage / Dentin / Dentin-Bonding Agents / Humans / Materials Testing / Methacrylates / Microscopy, Electron, Scanning / Resin Cements / Silicon Compounds / Smear Layer / Stress, Mechanical / Tensile Strength / Time Factors / Water (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2011-001 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21778604 ● Summary page in Scopus @ Elsevier: 2-s2.0-80051568542 (DOI: 10.4012/dmj.2011-001, PubMed: 21778604, Elsevier: Scopus)
92.	Naoko Seki, Masatoshi Nakajima, Ryuzo Kishikawa, Keiichi Hosaka, M Richard Foxton and Junji Tagami : The influence of light intensities irradiated directly and indirectly through resin composite to self-etch adhesives on dentin bonding., Dental Materials Journal, Vol.30, No.3, 315-322, 2011. (要約) This study was designed to evaluate effects of light-irradiated intensities directly and indirectly through resin composites to one- and two-step self-etch adhesives on dentin bonding. One-step (Clearfil S(3) Bond; TS, Bond Force; BF) or two-step (Clearfil SE Bond; SE) self-etch adhesives was applied to dentin surface. The adhesive agent was light-cured with light-intensity of 350 or 600 mW/cm(2), and then resin composite with different colors (translucent or opaque shade) was filled and light-cured with the same light-intensity as the bonding procedure. After 24 h water storage, bond strengths to dentin were determined using µTBS test. For the 600 and 350 mW/cm(2) groups, translucent shade resin obtained higher µTBS than opaque shade resin. Using SE and BF, the 350 mW/cm(2) group in translucent shade resin was higher µTBS than the 600 mW/cm(2) group in opaque shade resin, while TS showed no different µTBS between them. (キーワード) Bisphenol A-Glycidyl Methacrylate / Color / Composite Resins / Dental Leakage / Dental Materials / Dental Stress Analysis / Dentin / Dentin-Bonding Agents / Humans / Light / Light-Curing of Dental Adhesives / Materials Testing / Methacrylates / Microscopy, Electron, Scanning / Polyethylene Glycols / Polymethacrylic Acids / Radiation Dosage / Resin Cements / Stress, Mechanical / Surface Properties / Tensile Strength / Time Factors / Water (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2010-156 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21597217 ● Summary page in Scopus @ Elsevier: 2-s2.0-79958020573 (DOI: 10.4012/dmj.2010-156, PubMed: 21597217, Elsevier: Scopus)
93.	Masahiro Takahashi, Masatoshi Nakajima, Keiichi Hosaka, Masaomi Ikeda, M Richard Foxton and Junji Tagami : Long-term evaluation of water sorption and ultimate tensile strength of HEMA-containing/-free one-step self-etch adhesives., Journal of Dentistry, Vol.39, No.7, 506-512, 2011. (要約) For the HEMA-containing adhesives, Wsp increased and UTS decreased over time. On the other hand, for the HEMA-free adhesive, Wsp and UTS did not significantly change even after 360-day water-storage. (キーワード) Absorption / Analysis of Variance / Dental Bonding / Dental Stress Analysis / Dentin-Bonding Agents / Hydrophobic and Hydrophilic Interactions / Materials Testing / Methacrylates / Resin Cements / Statistics, Nonparametric / Tensile Strength / Water (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jdent.2011.04.008 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21575671 ● Summary page in Scopus @ Elsevier: 2-s2.0-80955177117 (DOI: 10.1016/j.jdent.2011.04.008, PubMed: 21575671, Elsevier: Scopus)
94.	Masako Okuma, Masatoshi Nakajima, Keiichi Hosaka, Shima Itoh, Masaomi Ikeda, M Richard Foxton and Junji Tagami : Effect of composite post placement on bonding to root canal dentin using 1-step self-etch dual-cure adhesive with chemical activation mode., Dental Materials Journal, Vol.29, No.6, 642-648, 2010. (要約) This study evaluated the effect of composite post placement and/or light-irradiation of dual-cure resin composite on adhesion to root canal dentin using the chemical activation mode of a 1-step self-etch dual-cure adhesive. Post spaces were prepared in extracted premolars. Root canal spaces were applied with Unifil Core EM Self-Etching Bond, which was chemically-polymerized, and then filled with Unifil Core EM with or without the placement of composite post. Half the specimens of each group were light-cured for 10 seconds and the other half were chemically-cured in darkness for 30 minutes. After 24 h storage, microtensile bond strengths (µTBS) at the coronal and apical regions were measured. When light-curing, placement of the composite post significantly reduced the µTBS to root canal dentin. On the other hand, when chemical-curing, there was no significant difference in µTBS between with and without placement of the composite post. (キーワード) Adolescent / Composite Resins / Dental Materials / Dental Pulp Cavity / Dental Stress Analysis / Dentin / Dentin-Bonding Agents / Humans / Light-Curing of Dental Adhesives / Materials Testing / Microscopy, Electron, Scanning / Polymerization / Post and Core Technique / Self-Curing of Dental Resins / Silanes / Stress, Mechanical / Surface Properties / Tensile Strength / Time Factors (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2010-006 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21099152 ● Summary page in Scopus @ Elsevier: 2-s2.0-78650043995 (DOI: 10.4012/dmj.2010-006, PubMed: 21099152, Elsevier: Scopus)
95.	Shima Itoh, Masatoshi Nakajima, Keiichi Hosaka, Masako Okuma, Masahiro Takahashi, Yuko Shinoda, Naoko Seki, Masaomi Ikeda, Ryuzo Kishikawa, M Richard Foxton and Junji Tagami : Dentin bond durability and water sorption/solubility of one-step self-etch adhesives., Dental Materials Journal, Vol.29, No.5, 623-630, 2010. (要約) The purpose of this study was to evaluate the dentin bonding durability of three HEMA-containing one-step self-etch adhesives after one-year water storage and to measure the amounts of their water sorption/solubility. OptiBond All-In-One (OP), Bond Force (BF) and Clearfil S³Bond (S³) were applied to the dentin surfaces according to manufacturers' instructions. Bond strengths to dentin were determined using µTBS test after water storage for 24 hours, six months, and one year. In addition, water sorption and solubility of the polymerized adhesives were measured. The µTBS of S³ and OP significantly decreased after one year. On the other hand, for BF there were no significant differences in µTBS between all storage periods. There were significant differences in water sorption and solubility among the adhesives (BF>S³>OP). The initial amounts of water sorption and solubility of the three adhesives did not affect their bonding durability to dentin. (キーワード) Absorption / Adsorption / Bisphenol A-Glycidyl Methacrylate / Composite Resins / Dental Bonding / Dentin / Dentin-Bonding Agents / Humans / Materials Testing / Methacrylates / Microscopy, Electron, Scanning / Polyethylene Glycols / Polymerization / Polymethacrylic Acids / Resin Cements / Solubility / Stress, Mechanical / Surface Properties / Tensile Strength / Time Factors / Water (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2010-028 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20823619 ● Summary page in Scopus @ Elsevier: 2-s2.0-78149375474 (DOI: 10.4012/dmj.2010-028, PubMed: 20823619, Elsevier: Scopus)
96.	Ayako Arimoto, Masatoshi Nakajima, Keiichi Hosaka, Kozo Nishimura, Masaomi Ikeda, M Richard Foxton and Junji Tagami : Translucency, opalescence and light transmission characteristics of light-cured resin composites., Dental Materials, Vol.26, No.11, 1090-1097, 2010. (要約) At the 0.5mm thickness, the translucency (TP) and opalescence (OP) of resin composites had a significant correlation with a diffuse transmission property (DF). When more than 1.0mm thickness of resin composites, translucency and opalescence were influenced by the thickness, in which translucency significantly decreased and opalescence significantly increased. (キーワード) Bisphenol A-Glycidyl Methacrylate / Color / Colorimetry / Composite Resins / Dental Materials / Humans / Light / Optical Phenomena / Photometry / Spectrophotometry / Surface Properties (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.dental.2010.07.009 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20692691 ● Summary page in Scopus @ Elsevier: 2-s2.0-77957285179 (DOI: 10.1016/j.dental.2010.07.009, PubMed: 20692691, Elsevier: Scopus)
97.	Keiichi Hosaka, Masatoshi Nakajima, Masahiro Takahashi, Shima Itoh, Masaomi Ikeda, Junji Tagami and H David Pashley : Relationship between mechanical properties of one-step self-etch adhesives and water sorption., Dental Materials, Vol.26, No.4, 360-367, 2010. (要約) The moduli of elasticity and ultimate tensile strengths of the adhesives fell significantly after water-storage. Water sorption depended on the constituents of the adhesive systems. The percent decreases in the ultimate tensile strengths of the adhesives were related to water sorption, while the percent reductions in the moduli of elasticity of the adhesives were not related to water sorption. (キーワード) Absorption / Acid Etching, Dental / Adhesives / Analysis of Variance / Dental Stress Analysis / Dentin-Bonding Agents / Elastic Modulus / Materials Testing / Polymers / Regression Analysis / Resin Cements / Statistics, Nonparametric / Tensile Strength / Water (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.dental.2009.12.007 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20053432 ● Summary page in Scopus @ Elsevier: 2-s2.0-76849108949 (DOI: 10.1016/j.dental.2009.12.007, PubMed: 20053432, Elsevier: Scopus)
98.	Takanashi Hiroyuki, Keiichi Hosaka, Kishikawa Ryuzo, Otsuki Masayuki and Tagami Junji : The effect of dentin preparation with an ultrasonic abrasion on the microtensile bond strength of self-etch adhesive systems, International Chinese Journal of Dentistry, Vol.10, No.1, 7-15, 2010.
99.	岸川隆蔵, 田代浩史, 趙永哲, 保坂啓一, 稲井紀通, 田上順次 : 光照射の有無がデュアルキュア型レジンセメントの象牙質接着強さに与える影響, 接着歯学, Vol.27, No.3, 101-105, 2009年. (キーワード) レジンセメント / 光照射 / 引張り接着強さ (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1572543025859653120 (CiNii: 1572543025859653120)
100.	Gen Taniguchi, Masatoshi Nakajima, Keiichi Hosaka, Nanako Iwamoto, Masaomi Ikeda, M Richard Foxton and Junji Tagami : Improving the effect of NaOCl pretreatment on bonding to caries-affected dentin using self-etch adhesives., Journal of Dentistry, Vol.37, No.10, 769-775, 2009. (要約) The effects of NaOCl pretreatment on bonding of both self-etch adhesives were dependent upon type of dentin (normal and caries-affected dentin) and the treatment time. (キーワード) Composite Resins / Dental Bonding / Dental Caries / Dental Etching / Dental Restoration, Permanent / Dental Stress Analysis / Dentin / Dentin Permeability / Dentin-Bonding Agents / Humans / Molar / Oxidants / Reducing Agents / Smear Layer / Sodium Hypochlorite / Tensile Strength / Time Factors (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jdent.2009.06.005 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19589634 ● Search Scopus @ Elsevier (PMID): 19589634 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jdent.2009.06.005 (DOI: 10.1016/j.jdent.2009.06.005, PubMed: 19589634)
101.	Keiichi Hosaka, Y Nishitani, J Tagami, M Yoshiyama, W W Brackett, A K Agee, R F Tay and H D Pashley : Durability of resin-dentin bonds to water- vs. ethanol-saturated dentin., Journal of Dental Research, Vol.88, No.2, 146-151, 2009. (要約) Higher 24-hour resin-dentin bond strengths are created when ethanol is used to replace water during wet bonding. This in vitro study examined if ethanol-wet-bonding can increase the durability of resin-dentin bonds over longer times. Five increasingly hydrophilic experimental resin blends were bonded to acid-etched dentin saturated with water or ethanol. Following composite build-ups, the teeth were reduced into beams for 24-hour microtensile bond strength evaluation, and for water-aging at 37 degrees C for 3, 6, or 12 months before additional bond strength measurements. Although most bonds made to water-saturated dentin did not change over time, those made to ethanol-saturated dentin exhibited higher bond strengths, and none of them fell over time. Decreased collagen fibrillar diameter and increased interfibrillar spacing were seen in hybrid layers created with ethanol-wet-bonding. Increases in bond strength and durability in ethanol-wet-bonding may be due to higher resin uptake and better resin sealing of the collagen matrix, thereby minimizing endogenous collagenolytic activities. (キーワード) Acid Etching, Dental / Composite Resins / Dental Bonding / Dental Stress Analysis / Dentin / Dentin Permeability / Dentin-Bonding Agents / Ethanol / Fibrillar Collagens / Humans / Hydrophobic and Hydrophilic Interactions / Resin Cements / Silicon Dioxide / Solubility / Tensile Strength / Time Factors / Water / Wettability / Zirconium (出版サイトへのリンク) ● Publication site (DOI): 10.1177/0022034508328910 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19278986 ● Search Scopus @ Elsevier (PMID): 19278986 ● Search Scopus @ Elsevier (DOI): 10.1177/0022034508328910 (DOI: 10.1177/0022034508328910, PubMed: 19278986)
102.	R Marcela Carrilho, R Franklin Tay, M Adam Donnelly, A Kelli Agee, M Ricardo Carvalho, Keiichi Hosaka, Alessandra Reis, D Alessandro Loguercio and H David Pashley : Membrane permeability properties of dental adhesive films., Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.88, No.2, 312-320, 2009. (要約) This study evaluated the permeability properties of five experimental resin membranes that ranged from relatively hydrophobic to relatively hydrophilic to seal acid-etched dentin saturated with water or ethanol. The experimental resins (R1, R2, R3, R4, and R5) were evaluated as neat bonding agents or as solutions solvated with ethanol (70% resin/30% ethanol). The quality of dentin sealing by these experimental resins was expressed in terms of reflection coefficients calculated as the ratio of the effective osmotic pressure to the theoretical osmotic pressure of test solutions. The effective osmotic pressure produced across resin-bonded dentin was induced in hypertonic solutions (CaCl(2) or albumin) at zero hydrostatic pressure. The outward fluid flow induced by these solutions was brought to zero by applying an opposing negative hydrostatic pressure. The least hydrophilic resins blends, R1 and R2, exhibited significantly (p < 0.05) higher reflection coefficients than the most hydrophilic resins (R4 and R5) in both conditions of dentin saturation (water and ethanol). The reflection coefficients of neat resins were, in general, significantly higher when compared with their corresponding solvated versions in both conditions of dentin saturation. In dentin saturated with ethanol, bonding with neat or solvated resins, resulted in reflection coefficients that were significantly higher when compared with the results obtained in dentin saturated with water. Reflection coefficients of CaCl(2) (ca. 1 x 10(-4)) were significantly lower (p < 0.05) than for albumin (ca. 3 x 10(-2)). Application of hydrophobic resins may provide better sealing of acid-etched dentin if the substrate is saturated with ethanol, instead of water. (キーワード) Albumins / Dental Cements / Humans / Osmotic Pressure / Solubility (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.b.30968 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18161803 ● Search Scopus @ Elsevier (PMID): 18161803 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.30968 (DOI: 10.1002/jbm.b.30968, PubMed: 18161803)
103.	中島正俊, 谷口玄, Kunawarote SITTHIKORN, 保坂啓一, 高橋真広, 岩本奈々子, 岸川隆蔵, 田上順次 : う蝕象牙質に対する2ステップ・セルフエッチ接着システムの接着性能の改良, 日本歯科保存学雑誌, Vol.51, No.4, 396-402, 2008年. (要約) う蝕象牙質へのレジンの接着性能は,健全象牙質に比べ低いことが知られている.その原因として,う蝕象牙質の形態学的構造,生化学的性状および機械的性状が,健全象牙質とは著しく異なっていることなどが挙げられている.また,被着象牙質表面を覆っているスミヤー層の性状も接着性能に影響を及ぼす可能性がある.象牙質切削時に表面に形成されるスミヤー層は,被切削体と構成成分は同じであると考えられている.したがって,う蝕象牙質削面に形成されるスミヤー層は,健全象牙質のスミヤー層と比べて有機成分の割合が多いと思われる.本研究では,う蝕象牙質内層(う蝕罹患(影響)象牙質:caries-affected dentin)へのレジンの接着性能の改良を目指して,スミヤー層の構造がう蝕象牙質と健全象牙質とで異なることに着目し,スミヤー層表面の有機成分を溶解・除去することができる次亜塩素酸ナトリウム水溶液による前処理が,う蝕罹患象牙質への2ステップ・セルフエッチ接着システム(クリアフィルメガボンドFA®,クラレメディカル)の接着強さに及ぼす影響について検討した.その結果,次亜塩素酸ナトリウム水溶液30秒処理後,還元効果のある芳香族スルフィン酸塩を主成分としたアクセル®(サンメディカル)にて30秒間処理することにより,う蝕罹患象牙質に対するクリアフィルメガボンドFA®の接着強さを,無処理-健全象牙質に対する接着強さと同程度に改善させることができた.また,健全象牙質を次亜塩素酸ナトリウム水溶液30秒処理後,アクセル®にて30秒間処理した場合と無処理-健全象牙質に対する接着強さの間に有意差は認められなかった.健全象牙質とう蝕罹患象牙質におけるスミヤー層の性状の違いが,2ステップ・セルフエッチ接着システムのう蝕罹患象牙質に対する接着強さの低下の大きな要因である可能性が示唆された. (キーワード) 接着強さ / う蝕象牙質 / 次亜塩素酸ナトリウム (出版サイトへのリンク) ● Publication site (DOI): 10.11471/shikahozon.51.396 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205522452736 ● Search Scopus @ Elsevier (DOI): 10.11471/shikahozon.51.396 (DOI: 10.11471/shikahozon.51.396, CiNii: 1390001205522452736)
104.	Keiichi Hosaka, Masatoshi Nakajima, Francesca Monticelli, Marcela Carrilho, Monica Yamauti, Juthatip Aksornmuang, Yoshihiro Nishitani, R Franklin Tay, H David Pashley and Junji Tagami : Influence of hydrostatic pulpal pressure on the microtensile bond strength of all-in-one self-etching adhesives., The Journal of Adhesive Dentistry, Vol.9, No.5, 437-442, 2007. (要約) The microTBS of the two all-in-one adhesive systems decreased when PP was applied. However, the microTBS of both self-etching primer adhesives did not decrease under PP. (キーワード) Acid Etching, Dental / Analysis of Variance / Dental Bonding / Dental Pulp / Dental Stress Analysis / Dentin / Dentin-Bonding Agents / Humans / Hydrostatic Pressure / Statistics, Nonparametric / Tensile Strength (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18297824 ● Search Scopus @ Elsevier (PMID): 18297824 (PubMed: 18297824)
105.	Keiichi Hosaka, Junji Tagami, Yoshihiro Nishitani, Masahiro Yoshiyama, Marcela Carrilho, R Franklin Tay, A Kelli Agee and H David Pashley : Effect of wet vs. dry testing on the mechanical properties of hydrophilic self-etching primer polymers., European Journal of Oral Sciences, Vol.115, No.3, 239-245, 2007. (要約) Self-etching primers and adhesives contain very hydrophilic methacrylate monomers that result in high water sorptions by their polymers. Water sorption plasticizes the polymers and lowers their mechanical properties. The purpose of this work was to rank the hydrophilicity of a series of acidic primers by their Hoy's solubility parameters (delta) to determine if there was a significant relationship between the delta of polymers and their mechanical properties. A series of six acidic primer blends containing a fixed concentration of phenyl-P but variable amounts of 2-hydroxyethyl methacrylate (HEMA), 2,2 bi[4-(2-hydroxy-3-methacryloyloxy)propane (BisGMA), and triethylene-glycol dimethacrylate (TEGDMA) was formulated and their Hoy's solubility parameters calculated. The polymers were cast into small 'I' beams and light-cured. The modulus of elasticity (E) and ultimate tensile strength (UTS) were measured in dry polymers and after immersion in water for 24 h. The results showed significant correlations between E and UTS under dry or wet conditions. Both E and UTS fell significantly when the specimens were immersed in water. After water immersion, the E and UTS showed significant correlations with Hoy's delta(p) values. Both E and UTS correlated significantly with the BisGMA concentration of the polymers, either wet or dry. The percentage changes in E or UTS were significantly correlated with the water sorption of the polymers. (キーワード) Absorption / Acid Etching, Dental / Bisphenol A-Glycidyl Methacrylate / Dental Bonding / Dental Stress Analysis / Dentin-Bonding Agents / Desiccation / Elasticity / Materials Testing / Methacrylates / Organophosphorus Compounds / Pliability / Polyethylene Glycols / Polymethacrylic Acids / Resin Cements / Solubility / Statistics, Nonparametric / Tensile Strength / Water (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1600-0722.2007.00452.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17587300 ● Search Scopus @ Elsevier (PMID): 17587300 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1600-0722.2007.00452.x (DOI: 10.1111/j.1600-0722.2007.00452.x, PubMed: 17587300)
106.	Yoshihiro Nishitani, Masahiro Yoshiyama, Keiichi Hosaka, Junji Tagami, Adam Donnelly, Marcela Carrilho, R Franklin Tay and H David Pashley : Use of Hoy's solubility parameters to predict water sorption/solubility of experimental primers and adhesives., European Journal of Oral Sciences, Vol.115, No.1, 81-86, 2007. (要約) Self-etching primers and adhesives contain very hydrophilic acidic monomers that result in high water sorption/solubilities of their polymers. However, the chemical composition of these products varies widely. The purpose of this work was to vary the chemical composition of experimental self-etching primers and adhesives to determine if the water sorption/solubility of the polymers were affected in a predictable manner. The Hoy's solubility parameters of these mixtures were calculated to permit ranking of the degree of hydrophilicity of the polymers. Water sorption/solubility was measured according to ISO 4049. The results showed highly significant (R(2) = 0.86, P < 0.001) correlations between water sorption and Hoy's solubility parameter for polar forces (delta(p)) of the polymers. Similar correlations were obtained between polymer solubility and delta(p). When these results were compared with previously published results obtained with more hydrophobic resins, excellent correlations were obtained, indicating that Hoy's delta(p) values may be used to predict the water sorption behavior of methylmethacrylate polymers. (キーワード) Absorption / Adhesives / Analysis of Variance / Dental Etching / Dental Stress Analysis / Methacrylates / Methylmethacrylates / Polymers / Regression Analysis / Resin Cements / Solubility / Water / Wettability (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1600-0722.2007.00430.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17305721 ● Search Scopus @ Elsevier (PMID): 17305721 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1600-0722.2007.00430.x (DOI: 10.1111/j.1600-0722.2007.00430.x, PubMed: 17305721)
107.	Keiichi Hosaka, Masatoshi Nakajima, Monica Yamauti, Juthatip Aksornmuang, Masaomi Ikeda, M Richard Foxton, H David Pashley and Junji Tagami : Effect of simulated pulpal pressure on all-in-one adhesive bond strengths to dentine., Journal of Dentistry, Vol.35, No.3, 207-213, 2006. (要約) The muTBS of OBF bonded specimens was lowered more by simulated PP than by storage time; specimens bonded with FBS were not sensitive to storage time in the absence of PP, but showed lower bond strengths at 1 and 3 months in the presence of PP. (キーワード) Composite Resins / Dental Bonding / Dental Pulp / Dentin / Dentin-Bonding Agents / Humans / Hydrostatic Pressure / Materials Testing / Methacrylates / Microscopy, Electron, Scanning / Stress, Mechanical / Surface Properties / Temperature / Tensile Strength / Time Factors / Water (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jdent.2006.08.001 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16989931 ● Search Scopus @ Elsevier (PMID): 16989931 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jdent.2006.08.001 (DOI: 10.1016/j.jdent.2006.08.001, PubMed: 16989931)
108.	Masatoshi Nakajima, Keiichi Hosaka, Monica Yamauti, M Richard Foxton and Junji Tagami : Bonding durability of a self-etching primer system to normal and caries-affected dentin under hydrostatic pulpal pressure in vitro., American Journal of Dentistry, Vol.19, No.3, 147-150, 2006. (要約) Hydrostatic pulpal pressure significantly reduced the bond strength to normal dentin after 1-month storage (P< 0.05), but did not affect the bond strength to caries-affected dentin. (キーワード) Analysis of Variance / Composite Resins / Dental Bonding / Dental Caries / Dental Pulp / Dental Stress Analysis / Dentin / Dentin Permeability / Dentin-Bonding Agents / Dentinal Fluid / Humans / Hydrostatic Pressure / Materials Testing / Resin Cements / Statistics, Nonparametric / Tensile Strength (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16838477 ● Search Scopus @ Elsevier (PMID): 16838477 (PubMed: 16838477)
109.	保坂啓一, 池田正臣, ヤマウチモニカ, 緒方美和子, 中島正俊, 田上順次 : 新規ワンステップボンディング材"One-Up Bond F Plus"の象牙質接着性能, 接着歯学, Vol.22, No.3, 177-185, 2004年. (キーワード) ワンステップボンド / 象牙質接着 / 微小引張り接着強さ / アクティブ処理 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282679324111744 (CiNii: 1390282679324111744)

総説・解説:

1.	細川育子, 保坂啓一 : 海外ジャーナルWatching 酸蝕症予防としてのレスベラトールの効果, デンタルダイヤモンド, Vol.49, No.5, 97, 2024年4月.
2.	保坂啓一, 渡邉佳一郎, 田中栄二, 中島正俊, 岩﨑智憲 : 【小児のCR(コンポジットレジン)充填アップデート】接着システムのアップデート, 小児歯科臨床, Vol.28, No.12, 15-26, 2023年12月.
3.	髙木仲人, 髙木香, 保坂啓一 : 歯のホワイトニングを活用したテーラーメイドの審美歯科治療, 日本歯科評論, Vol.83, No.12, 43-52, 2023年12月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520579830868256000 (CiNii: 1520579830868256000)
4.	内海雄太, 川野沙織, 松木優承, 大毛健一郎, 保坂啓一 : CR修復におけるコンテンポラリーアート : 審美性に配慮した臨床的アプローチの実際(11)デジタルワークフローを活用したコンポジットレジンインジェクションテクニック, 日本歯科評論, Vol.83, No.11, 10-13, 2023年11月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520016515849383296 (CiNii: 1520016515849383296)
5.	細川育子, 保坂啓一 : 海外ジャーナルWatching 審美的改善のための低粘性レジン浸潤法の有用性, デンタルダイヤモンド, Vol.48, No.13, 107, 2023年10月.
6.	武川大輔, 米倉和秀, 蔵本瞳, 伊田百美香, 細川由樹, 細川育子, 細川義隆, 菅俊行, 中西正, 保坂啓一 : 2級コンポジットレジン修復のキーポイント, Journal of Oral Health and Biosciences, Vol.36, No.1, 8-12, 2023年9月. (キーワード) 歯科医療 (dental care) (徳島大学機関リポジトリ) ● Metadata: 118637 (出版サイトへのリンク) ● Publication site (DOI): 10.20738/johb.36.1_8 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390016062665364224 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.36.1_8 (徳島大学機関リポジトリ: 118637, DOI: 10.20738/johb.36.1_8, CiNii: 1390016062665364224)
7.	Keiichi Hosaka : Advancing Minimal Intervention Dentistry: Emphasizing Digital Enhancement of Direct Composite Restorations with Refined Bonding Strategies and Innovative Non-destructive Terahertz Internal Observation, Journal of Oral Health and Biosciences, Vol.36, No.1, 1-7, Sep. 2023. (徳島大学機関リポジトリ) ● Metadata: 118636 (出版サイトへのリンク) ● Publication site (DOI): 10.20738/johb.36.1_1 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.20738/johb.36.1_1 (徳島大学機関リポジトリ: 118636, DOI: 10.20738/johb.36.1_1)
8.	椋由理子, 保坂啓一 : 正中離開に対する矯正治療とコンポジットレジン修復治療とのコンビネーション治療 : 7年経過長期症例, 日本歯科評論, Vol.83, No.6, 77-84, 2023年6月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520859616033565952 (CiNii: 1520859616033565952)
9.	髙木仲人, 保坂啓一 : ホワイトスポット病変(WSL)への対応について, 日本歯科評論, Vol.83, No.5, 45-55, 2023年5月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520296343321258880 (CiNii: 1520296343321258880)
10.	細川育子, 保坂啓一 : 海外ジャーナルWatching 漂白効果を予測するための新規方法の開発, デンタルダイヤモンド, Vol.Vol.48, No.5, 99, 2023年4月.
11.	保坂啓一 : 良好な歯質接着に基づき，デジタルとアナログを融合する新しいコンポジットレジン修復治療, 接着歯学, Vol.40, No.4, 126-129, 2022年12月. (出版サイトへのリンク) ● Publication site (DOI): 10.11297/adhesdent.40.4_126 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390577917543714944 ● Search Scopus @ Elsevier (DOI): 10.11297/adhesdent.40.4_126 (DOI: 10.11297/adhesdent.40.4_126, CiNii: 1390577917543714944)
12.	保坂啓一, 渡邉佳一郎, 鴨居浩平 : デジタル技術を融合した次世代CR修復 : クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(12・完)"フル"デジタルガイドCR修復へ : 疑問に答え,現在の到達点から未来を見据える, 日本歯科評論, Vol.82, No.12, 10-13, 2022年12月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520013021075705088 (CiNii: 1520013021075705088)
13.	武川大輔, 鴨居浩平, 保坂啓一 : デジタル技術を融合した次世代CR修復 : クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(11)バイレイヤー(2層)クリアインデックスを用いた下顎正中離開の修復, 日本歯科評論, Vol.82, No.11, 10-13, 2022年11月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520575444014801664 (CiNii: 1520575444014801664)
14.	保坂啓一, 大山正弘 : デジタル技術を融合した次世代CR修復 : クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(10)デジタルガイドダイレクトブリッジ修復(2)前歯部1歯欠損への対応, 日本歯科評論, Vol.82, No.10, 10-13, 2022年10月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520575263312419328 (CiNii: 1520575263312419328)
15.	米倉和秀, 鴨居浩平, 三枝克啓, 保坂啓一 : デジタル技術を融合した次世代CR修復 : クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(9)非う蝕性歯頸部欠損のCR修復, 日本歯科評論, Vol.82, No.9, 10-13, 2022年9月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520856893060832256 (CiNii: 1520856893060832256)
16.	細川育子, 大山正弘, 保坂啓一 : デジタル技術を融合した次世代CR修復 : クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(8)トゥースウェアに対するダイレクトCRベニア修復, 日本歯科評論, Vol.Vol.82, No.8, 10-13, 2022年8月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520856052608438912 (CiNii: 1520856052608438912)
17.	井内智貴, 米倉和秀, 鴨居浩平, 保坂啓一 : デジタル技術を融合した次世代CR修復 : クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(7)臼歯部隣接面の修復, 日本歯科評論, Vol.82, No.7, 10-13, 2022年7月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520292706226344832 (CiNii: 1520292706226344832)
18.	保坂啓一, 鴨居浩平, 田中栄二 : デジタル技術を融合した次世代CR修復 : クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(6)矯正治療とのコンビネーション治療, 日本歯科評論, Vol.82, No.6, 10-13, 2022年6月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520010997612859648 (CiNii: 1520010997612859648)
19.	保坂啓一, 佐藤大輔, 長谷川勇一 : デジタル技術を融合した次世代CR修復⑤:クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(5)失活歯に対するモノブロックレストレーション(ダイレクトクラウンCR), 日本歯科評論, Vol.82, No.5, 10-13, 2022年5月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520292251371336704 (CiNii: 1520292251371336704)
20.	保坂啓一, 田代浩史, 三木仁志, 本山靖治, 長谷川勇一, 鴨居浩平 : デジタル技術を融合した次世代CR修復④:クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(4)デジタルガイドコンポジットレジン修復:テクニックセンシティブな修復のシステム化, 日本歯科評論, Vol.82, No.4, 10-13, 2022年4月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1524232505996784896 (CiNii: 1524232505996784896)
21.	保坂啓一, 鴨居浩平 : デジタル技術を融合した次世代CR修復③:クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(3)デジタルガイドコンポジットレジン修復(臼歯部咬合面編), 日本歯科評論, Vol.82, No.3, 10-13, 2022年3月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1521417756226991488 (CiNii: 1521417756226991488)
22.	鴨居浩平, 長谷川勇一, 本山靖治, 石原洋樹, 渡邉佳一郎, 細川育子, 保坂啓一 : デジタル技術を融合した次世代CR修復②:クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(2)デジタルワークフローを活用したコンポジットインジェクションテクニック(後編), 日本歯科評論, Vol.82, No.2, 10-13, 2022年2月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1521417756223847680 (CiNii: 1521417756223847680)
23.	保坂啓一 : デジタル技術を融合した次世代CR修復 : クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(1)デジタルワークフローを活用したコンポジットインジェクションテクニック(前編), 日本歯科評論, Vol.82, No.1, 10-13, 2022年1月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523951031010124672 (CiNii: 1523951031010124672)
24.	保坂啓一, 本山靖治, 長谷川勇一 : クリアインデックスを使った次世代CR修復ーデジタル技術を活用したインジェクションテクニック, 日本歯科評論, Vol.81, No.10, 70-85, 2021年10月.
25.	保坂啓一, 高橋真広 : 接着様式の変遷と1ステップボンディングシステムおよび2ステップボンディングシステムへの期待, ザ·クインテッセンス, Vol.40, No.10, 63-71, 2021年10月.
26.	保坂啓一 : 保存修復学における機能審美再生へのCreativity Advanced MIデンティストリー, デンタルダイヤモンド, Vol.46, No.5, 38-49, 2021年4月.
27.	保坂啓一 : 接着性レジンの象牙質接着耐久性改良法の探求と接着破壊ダイナミクスの解明, 日本歯科保存学雑誌, Vol.63, No.6, 479-482, 2020年12月. (出版サイトへのリンク) ● Publication site (DOI): 10.11471/shikahozon.63.479 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1391975831225089920 ● Search Scopus @ Elsevier (DOI): 10.11471/shikahozon.63.479 (DOI: 10.11471/shikahozon.63.479, CiNii: 1391975831225089920)
28.	保坂啓一, 大槻昌幸 : エビデンスに基づいたホワイトニングの説明-患者さんからの質問に自信をもって答えるために治療後編 (Q5.)詰め物や被せた物が白くなりませんでした, 日本歯科評論, Vol.80, No.10, 110-111, 2020年10月.
29.	保坂啓一, 中島正俊, 田代浩史, 高橋真広, 田上順次 : The Power of Direct Composite Restoration ─今，最高の接着と歯の保存の提案─, ザ·クインテッセンス, Vol.38, No.10, 40-61, 2019年10月.
30.	高橋真広, 保坂啓一 : 接着システムの取り扱い : 確実な接着を獲得するために (新春特集歯科接着のエッセンスをわが手に : 接着を制する者が臨床を制する), 日本歯科評論, Vol.79, No.1, 60-63, 2019年1月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523388080233976192 (CiNii: 1523388080233976192)
31.	岸川隆蔵, 久野裕介, 保坂啓一, 中島正俊 : oral study & therapy 高接着性能&短時間処理が可能な1ステップシステム「クリアフィルユニバーサルボンド Quick ER」を活用した効率的なCR修復, 日本歯科評論, Vol.78, No.10, 143-148, 2018年10月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520291855005824512 (CiNii: 1520291855005824512)
32.	小林賢一, 保坂啓一 : う蝕，歯周病に次ぐ第三の疾患 Tooth Wearの基礎と臨床, --- 重篤なTooth Wear症例に対する合理的なフルマウスリコンストラクションその理論的背景と修復法 ---, ザ·クインテッセンス, Vol.37, No.1, 0070-0102, 2018年1月.
33.	保坂啓一 : 2級ダイレクトボンディングが上手くなりたい -マトリックスシステムの応用-, デンタルマガジン, No.163, 14-17, 2017年12月.
34.	保坂啓一, 他 : ユニバーサルボンドQuick活用症例ガイド01, モリタクリニカルケース, 2017年11月.
35.	保坂啓一, 佐藤健人, 中島正俊, 田上順次 : 新しい2ステップセルフエッチングシステムにおける，ボンドの重合性能の向上が象牙室接着性能およびその耐久性に及ぼす効果ークリアフィルメガボンド2-, 口腔病学会誌, Vol.83, No.3, 109-110, 2016年11月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1010000782306381324 (CiNii: 1010000782306381324)
36.	保坂啓一 : 特別寄稿バイオクリアーダイヤモンドウェッジの臨床例, Mリポ新聞, 2016年10月.
37.	保坂啓一 : 「クリアフィル®メガボンド2」が実現するコンポジットレジン修復の未来, デンタルマガジン, No.158, 20-23, 2016年9月.
38.	保坂啓一 : 前歯部コンポジットレジン審美修復で押さえるべきキーポイントーテクニックと器具・材料の使いこなしー, 歯科医療, Vol.30, No.2, 2016年4月.
39.	保坂啓一, 小林賢一, 猪越正直 : 重篤な酸蝕症例に対する接着技法によるフルマウスリハビリテーション3 ステップテクニック:パート1(訳), ザ·クインテッセンス, Vol.35, No.1, 197-209, 2016年3月.
40.	小林賢一, 猪越正直, 保坂啓一 : 重篤な酸蝕症例に対する接着技法によるフルマウスリハビリテーション3 ステップテクニック:パート3(訳), ザ·クインテッセンス, Vol.35, No.3, 675-690, 2016年3月.
41.	保坂啓一, 小林賢一, 猪越正直 : 重篤な酸蝕症例に対する接着技法によるフルマウスリハビリテーション3 ステップテクニック:パート2(訳), ザ·クインテッセンス, Vol.35, No.2, 429-443, 2016年2月.
42.	保坂啓一 : 歯冠破折歯へのコンポジットレジンMI審美修復, デンタルマガジン, No.148, 18-19, 2014年3月.

国際会議:

1.	Keiichi Hosaka : Advancing direct composite restoration: present and future with adhesive and digital technologies, Symposium Infuse 2024, Amsterdam, Netherlands, Nov. 2024.
2.	Keiichi Hosaka : Advancing Direct Composite Restoration with Adhesive and Digital Technologies, 2023 Kuraray Noritake Symposium: Celebrating Milestones in Dentistry, Dec. 2023.
3.	Keiichi Hosaka : Mastering MI Direct Composite Restoration: Exploring Advanced Materials and Techniques through the Shu-Ha-Ri Stages, The 7th International Conference on Sustainable Innovation (ICOSI 2023), Yogyakarta, Indonesia, Aug. 2023.
4.	Keiichi Hosaka : Improved composite injection molding technique (Hands-on workshop), 19th Scientific Meeting and Refresher Course in Dentistry, Jakarta, Feb. 2023.
5.	Keiichi Hosaka : Digitally-guided direct composite restoration reshaping the minimally invasive concept, 19th Scientific Meeting and Refresher Course in Dentistry, Jakarta, Feb. 2023.
6.	Iuchi Tomoki, Kazuhide Yonekura, Yumika Ida, Motoyama Yutaro, Ikeda Masaomi, Kenichi Hamada, Nakajima Masatoshi and Keiichi Hosaka : Are HEMA and 10-MDP necessary in the bonding agent of a 2-SEA?, The 7th International Congress on Adhesive Dentistry, Jun. 2022.
7.	Kazuhide Yonekura, Yumika Ida, Yu Tokizane, Taka-aki Yano, Iuchi Tomoki, Takeshi Yasui and Keiichi Hosaka : Nondestructive observation of adhesively cemented interface between dentin and indirect composite resin disks using a novel terahertz pulsed imaging technique, The 7th International Congress on Adhesive Dentistry, Jun. 2022.
8.	Tashiro Hirofumi, Miki Hitoshi, Tagami Junji, Takagaki Tomohiro, Keiichi Hosaka, Sato Takaaki, Hatayama Takashi and Shimada Yasushi : Clinical performance of mono-block direct composite crown restorations, The 7th International Congress on Adhesive Dentistry, Jun. 2022.
9.	Miki Hitoshi, Tashiro Hirofumi, Tagami Junji, Takagaki Tomohiro, Keiichi Hosaka, Sato Takaaki, Hatayama Takashi and Shimada Yasushi : Survival of the anterior mono-block direct composite crown, The 7th International Congress on Adhesive Dentistry, Jun. 2022.
10.	Sato Takaaki, Tashiro Hirofumi, Miki Hitoshi, Otani Kazunori, Nishimura Miho, Takahashi Masahiro, Keiichi Hosaka, Tagami Junji and Shimada Yasushi : Clinical Effectiveness of direct composite vs. zirconia resin-bonded fixed dental prostheses, The 7th International Congress on Adhesive Dentistry, Jun. 2022.
11.	Yang Yi, Inoue Go, Keiichi Hosaka, Ikeda Masaomi and Shimada Yasushi : The effect of deproteinizing pretreatment on bonding performance and acid resistance to eroded dentin, The 7th International Congress on Adhesive Dentistry, Jun. 2022.
12.	Keiichi Hosaka : The evolution and harmony of analog and digital in direct composite restorative challenges 2022, The 7th International Congress on Adhesive Dentistry, Jun. 2022.
13.	Keiichi Hosaka : Keynote Lecture: The evolution and harmony of analog and digital in direct restorative challenges, The Niken Memorial Scholarship Program Tokushima-Indonesia Student/Faculty Exchange Kickoff Remote Conference, Dec. 2021.
14.	Keiichi Hosaka : Direct restorative challenges based on adhesive dentistry 2021, Advanced Adhesion, Dental Materials, and Dental Pulp, Hokkaido University Summer Institute, Sep. 2021.
15.	Sanon Kittisak, Hatayama Takashi, Tagami Junji, Keiichi Hosaka and Nakajima Masatoshi : Bonding Durability of 1-SEAs to HOCl-Smear Layer Deproteinized Dentin, 2021 IADR/AADR/CADR General Session, Boston, USA, Jul. 2021.
16.	Tichy Antonin, Keiichi Hosaka, Yang Yi, Motoyama Yutaro, Keiichi Hosaka, Sumi Yasunori, Nakajima Masatoshi and Tagami Junji : A Multifaceted Evaluation of a Novel HEMA-Free Two-Step Self-Etch Adhesive, 2021 IADR/AADR/CADR General Session, Boston, USA, Jul. 2021.
17.	Citra Kusumasari, Masatoshi Nakajima, Ahmed Abdou, Takashi Hatayama, Antonin Tichy, Keiichi Hosaka and Junji Tagami : Papacarie and Carisolv Pretreatments Improve Dentin Bonding Using Self-etch Adhesives, 2020 IADR/AADR/CADR General Session, Washington, D.C., 2020.
18.	Tichy Antonin, Marek Brabec, Pavel Bradna, Keiichi Hosaka, Masatoshi Nakajima and Tagami Junji : Competing Risk Model for Bond Strength Data Analysis, 4th IADR-APR Congress, Nov. 2019.
19.	Citra KUSUMASARI, Masatoshi NAKAJIMA, Ahmed ABDOU, Takashi HATAYAMA, Keiichi Hosaka and Junji TAGAMI : Effect of Papain Enzyme and NaOCl-based Gel on Sealing Performances of Self-etch Adhesives, ConsAsia 2019, Seoul, Nov. 2019.
20.	A. Tichy, M. Brabec, P. Bradna, Keiichi Hosaka, M. Nakajima and J. Tagami : Competing Risk Model for Bond Strength Data Analysis, 4th Meeting of the International Association for Dental Research Asia-Pacific Region, Brisben, Austiralia, Nov. 2019.
21.	Keiichi Hosaka and Takashi Hatayama : The Power of Direct Composite Restoration, 20th NADTI Trade Exhibit, Manilla, Phillipines, Sep. 2019.
22.	Shimada Yasushi, Yoshiyama Yoshihiro, Luong Minh, Keiichi Hosaka, Yamaji Kozo, Araki Kazuyuki, Sadr Alireza, Miyazaki Takashi, Sumi Yasunori and Tagami Junji : Diagnosis of Unopened Occlusal Caries Using Swept-source Optical Coherence Tomography, 2019 IADR/AADR/CADR General Session, Vancouver, Canada, Jun. 2019.
23.	Keiichi Hosaka : Diagnosis of Unopened Occlusal Caries Using Swept-source Optical Coherence Tomography, 2019 IADR/AADR/CADR General Session, Vancouver, Jun. 2019.
24.	Keiichi Hosaka : The Power of Direct Composite Restoration -from Crown & Bridge to Occlusal Reconstruction-, 2019 International Congress on Adhesive Dentistry, Seattle, Jun. 2019.
25.	Erick Madrigal, Keiichi Hosaka, Masatoshi Nakajima, Masaomi Ikeda, Ahmed Abdou, Antonin Tichy and Junji Tagami : Influence of Tooth-storage in Chloramine-T Solution on Bovine Dentin TBS, 97th International Association for Dental Research (IADR), Vancouver, Jun. 2019.
26.	Keiichi Hosaka : Direct Composite Restoration Promotes Our Oral Health, The 41st Annual Dental Scientific Conference University of Medicine and Pharmacy, Ho Chi Minh, Apr. 2019.
27.	Keiichi Hosaka : Keys to Success in Direct Composite Restorative Challenges, 35th Annual American Academy of Cosmetic Dentistry Scientific Session, San Diego, Apr. 2019.
28.	Keiichi Hosaka : The Power of Direct Composite Restorations, The Legacy Lives On - 40 Years of Dental Innovations (KAI Dental Symposium 2018), Phoenix, Dec. 2018.
29.	保坂啓一 : MID(Minimal Intervention Dentistry)がもたらす歯科医，患者，医院の喜び!, 第8回日本国際歯科大会2018, 横浜, 2018年10月.
30.	保坂啓一 : ダイレクト修復がうまくなりたい, 第8回日本国際歯科大会2018, 横浜, 2018年10月.
31.	Keiichi Hosaka : Is Our Direct Composite Restoration Perfect?, International Symposium on Adhesive Dentistry in Okayama, Okayama, Oct. 2018.
32.	Y Komagamine, M Kanazawa, N Seki, K Mizutani, Keiichi Hosaka, W Komada, Moross Janelle, S Kuroda, I Morio and A Kinoshita : Effort Toward International Dental Education By Tokyo Medical And Dental University, 32nd IADR-SEA & 29th SEAADE, Da Nang, Vietnam, Sep. 2018.
33.	N Seki, Keiichi Hosaka, J Moross, M Sunaga, I Morio and A Kinoshita : Evaluating an Online Course on Clinical Expertise with Computer-assisted Simulation Materials, The 29th SEAADE Annual Scientific Meeting, Da Nang, Vietnam, Sep. 2018.
34.	Yasushi Shimada, Keiichi Hosaka, Kazuyuki Araki, Alireza Sadr, Takashi Miyazaki, Yasunori Sumi, Junji Tagami and Masahiro Yoshiyama : 3D Diagnosis of Proximal Caries Using Swept-source Optical Coherence Tomography, 2018 IADR/PER General Session, London, Jul. 2018.
35.	Keiichi Hosaka, Junji Tagami, Juri Hayashi, Daisuke Araoka, Masatoshi Nakajima, Richard Foxton, Masaomi Ikeda, Wuri Han, Yo Shibata and Takashi Miyazaki : Eight-year Durability of Resin-dentin Interfaces of a 1-SEA, 2018 IADR/PER General Session, London, Jul. 2018.
36.	Masatoshi Nakajima, Junji Tagami, Yukinori Kano, Asami Aida, Ayaka Chiba, Keiichi Hosaka, Naoko Seki, Richard Foxton, Taweesak Prasansuttiporn and Ornnicha Thanatvarakorn : Color adaptation at enamel-composite borders with different incidnet-light directions, 96th IADR/PER General Session, London, Jul. 2018.
37.	Dhaifallah Alqarni, Keiichi Hosaka, Teerapong Mamanee, Masatoshi Nakajima, Masaomi Ikeda and Junji Tagami : Effect of different surface treatments on repair uTBS of composite bonded to resin matrix after water exposure, The 10th World Congress of International Federation of Esthetic Dentistry, Toyama, Sep. 2017.
38.	Keiichi Hosaka : Bioactive technology meets MI esthetic direct composite restorations. - The present and future -, The 10th World Congress of International Federation of Esthetic Dentistry, Toyama, Sep. 2017.
39.	TTT Nguyen, N Seki, J Moross, Keiichi Hosaka, M Sunaga, I Morio and A Kinoshita : The effectiveness of newly developed computer-assisted simulation materials on overseas learners, The 28th SEAADE (South East Asia Association for Dental Education) Annual Scientific Meeting, Taipei, Aug. 2017.
40.	Yukari Noda, Masahiro Takahashi, Teerapong mamanee, Masatoshi Nakajima, Masaomi Ikeda, Tomohiro Takagaki, Keiichi Hosaka and Junji Tagami : Effect of universal primer/thermocycling on bond strength to ceramics, 2016 AADR/CADR Annual Meeting, Los Angeles, Mar. 2016.
41.	Masatoshi Nakajima, Ornnicha Thanatvarakorn, Taweesak Prasansuttiporn, Keiichi Hosaka and Junji Tagami : Effect of smear layer-deproteinizing on dentin bonding of self-etch adhesives, 45th AADR, Los Angeles, Mar. 2016.
42.	T Hatayama, M Nakajima, Keiichi Hosaka, K Kainose, N Wakabayashi and J Tagami : Stress Distribution in Resin-Core Build-Up Tooth under Different Load Directions, Academy of Dental Materials 2015 Annual Meeting, Lahaina, Maui, HI, Oct. 2015.
43.	M Nakajima, M Takahashi, T Mamanee, S Thitthaweerat, N Seki, Keiichi Hosaka and J Tagami : Bond Strengths of Dual-Cure Adhesive Resin Cements to Dentin, Academy of Dental Materials 2015 Annual Meeting, Lahaina, Maui, HI, Oct. 2015.
44.	Keiichi Hosaka : Science meets practice, 9th Iranian General Dentists Association Congress Tehran, Tehran, Iran, Jan. 2015.
45.	Keiichi Hosaka : Esthetic and functional composite restorations -material selection and technique-, 9th Iranian General Dentists Association Congress Tehran, Tehran, Iran, Jan. 2015.
46.	Keiichi Hosaka : ''From Fillings toward Restorations'' Great Potentials of Direct Composite Restorations, 9th Iranian General Dentists Association Congress, Tehran, Iran, Jan. 2015.
47.	Keiichi Hosaka : Three-year Evaluation of Direct Composite Restorations in a Multicenter Prospective Trial, 6th IAD, Bangkok, Jan. 2015.
48.	Keiichi Hosaka : Esthetic and functional direct composite restoration based on adhesive dentistry, 36th Annual Scientific Conference on Dental Research, University of Medicine and Pharmacy, Ho Chi Minh, Apr. 2014.
49.	Keiichi Hosaka, M Takahashi, M Nakajima, Y Nishitani, DH Pashley and J Tagami : Ultra-high-speed Fracture Observation in Resin-dentin Interface under Microtensile Load, 6th International Congress on Adhesive Dentistry, Philadelphia, Jun. 2013.
50.	M. TAKAHASHI, T. WIBOONPIN, Keiichi Hosaka, M. NAKAJIMA and J. TAGAMI : Color Changes of Resin Composite after Immersion in Staining Solutions, 2012 IADR/LAR General Session, Iguaçu Falls, Brazil, Jun. 2012.
51.	Keiichi Hosaka, M. NAKAJIMA, M. TAKAHASHI, S. THITTHAWEERAT, M. OTSUKI and J. TAGAMI : Effect of Dentin Surface Moisture on mTBS of Solvent-free 1-SEA, 2012 IADR/LAR General Session, Iguaçu Falls, Brazil, Jun. 2012.
52.	Keiichi Hosaka, M. NAKAJIMA, M. TAKAHASHI, Y. SHINODA, W. SAKANO, R. KISHIKAWA and J. TAGAMI : Microtensile Bond Strength of the newly developed one-step adhesive, IADR/AADR/CADR 89th General Session and Exhibition, San Diego, Mar. 2011.
53.	M. TAKAHASHI, M. NAKAJIMA, Keiichi Hosaka, S. ITOH and J. TAGAMI : Water Sorption and Ultimate Tensile Strength of One-Step Adhesives, 2010 IADR/PER General Session, Barcelona, 2010.
54.	N. SEKI, R. KISHIKAWA, Keiichi Hosaka, M. NAKAJIMA and J. TAGAMI : Influence of Light-irradiation Intensity on Bonding to One-step vs Two-step, 2010 IADR/PER General Session, Barcelona, 2010.
55.	M. NAKAJIMA, Y. SHINODA, M. TAKAHASHI, Keiichi Hosaka and J. TAGAMI : Effect of HEMA on Dentin Bonding Durability of Self-etch Adhesives, 2010 IADR/PER General Session, Barcelona, 2010.
56.	R. KISHIKAWA, K. MATIN, T. OYANAGI, M. GYO, N. SEKI, Keiichi Hosaka, T. HATAYAMA, M. OTSUKI and J. KATO : Bactericidal Effect of TiO2 Incorporated H2O2 Photocatalysing by 405-nm Diode-laser, 2010 IADR/PER General Session, Barcelona, 2010.
57.	Keiichi Hosaka, M. NAKAJIMA, M. TAKAHASHI, W. SAKANO, R. KISHIKAWA, D. PASHLEY and J. TAGAMI : The effect of water-sorption on the mechanical-property of self-etch adhesives, IADR/AADR/CADR 88th General Session and Exhibition, Barcelona, 2010.
58.	M. OKUMA, M. NAKAJIMA, Keiichi Hosaka, S. ITOH, R. KISHIKAWA, M. IKEDA and J. TAGAMI : Effect of indirect-post placement on bonding to root canal dentin, 2009 IADR/AADR/CADR General Session, Miami, 2009.
59.	S. ITOH, M. NAKAJIMA, Keiichi Hosaka, M. OKUMA, Y. SHINODA, M. TAKAHASHI, N. SEKI, R. KISHIKAWA, M. IKEDA and J. TAGAMI : Dentin Bonding Durability of Recent Self-etching Adhesives, 2009 IADR/AADR/CADR General Session, Miami, 2009.
60.	Yoshihiro Nishitani, Masahiro Yoshiyama, Tomohiro Hoshika, Kei Takahashi, Keiichi Hosaka, Junji Tagami, R. Frankiln Tay and David Pashley : Effects of incorporating chlorhexidine into all-in-one adhesives, 2008 IADR/CADR General Session, Toronto, Jul. 2008.
61.	G. TANIGUCHI, S. KUNAWARO TE, Keiichi Hosaka, N. IWAMOTO, M. IKEDA, M. NAKAJIMA and J. TAGAMI : Improvement of Bond Strength to Caries-Affected Dentin, 2008 IADR/CADR General Session, Toronto, Jul. 2008.
62.	M. NAKAJIMA, G. TANIGUCHI, S. KUNAWAROTE, Keiichi Hosaka, N. IWAMOTO and M. TAKAHASHI : Effect of Antioxidant/NaOCl.Treatment on Bonding to Caries-Affected Dentin, 2008 IADR/CADR General Session, Toronto, Jul. 2008.
63.	Keiichi Hosaka, M. NAKAJIMA, M. TAKAHASHI, S. ITO, M. IKEDA, G. TANIGUCHI, Y. NISHITANI, M. YOSHIYAMA, D. H. PASHLEY, F. R. TAY and J. TAGAMI : Mechanical properties of one-step adhesive-polymers in dry vs. wet, 2008 IADR/CADR General Session, Toronto, Jul. 2008.
64.	D. H. PASHLEY, Y. NISHITANI, M. YOSHIYAMA, Keiichi Hosaka, K. AGEE, W. W. BRACKETT and F. R. TAY : Durability of Resins Bonded to Water Vs. Ethanol-Saturated Acid-Etched Dentin, 2008 AADR/CADR Annual Meeting, Dallas, Apr. 2008.
65.	David Pashley, Kelli Agee, Keiichi Hosaka, Yoshihiro Nishitani, M. Ricardo Carvalho and R. Franklin Tay : Macrohybrid Layer: Correlations Between Changes in Matrix Height and μTBS, 2007 IADR/AADR/CADR General Session, New Orleans, 2007.
66.	Oliveira Rocha Marcela Carrilho, Adam Donnelly, M. Ricardo Carvalho, Yoshihiro Nishitani, Keiichi Hosaka, Mario Goes De, R. Franklin Tay and David Pashley : Quality of Dentin Sealing provided by Adhesive-Resins/Resin-Tags, 2007 IADR/AADR/CADR General Session, New Orleans, 2007.
67.	Keiichi Hosaka, Junji Tagami, D.h. Pashley, Nakajima Masatoshi, Monticelli Francesca, Oliveira Rocha Marcela Carrilho, Monica Yamauti, Juthatip Aksornmuang, Yoshihiro Nishitani and F.r. Tay : Effect of Simulated Pulpal Pressure on Self-etching Primer Adhesive mTBS, IADR/AADR/CADR General Session, New Orleans, 2007.
68.	Monica Yamauti, Keiichi Hosaka, Masaomi Ikeda, Miwako Ogata, Masatoshi Nakajima, M. Otsuki and Junji Tagami : Effects of application technique of all-in-one adhesives on dentin bonding, 2006 IADR General Session, Brisbane, 2006.
69.	Keiichi Hosaka, Monica Yamauti, Juthatip Aksornmuang, Masaomi Ikeda, Masatoshi Nakajima, Junji Tagami and H. David Pashley : mTBS of One-step Adhesive Systems under Hydrostatic Pulpal Pressure, 2006 AADR/CADR Annual Meeting, Orlando, 2006.
70.	Keiichi Hosaka : Bonding Durability of All-in-One Adhesives under Hydrostatic Pulpal Pressure, 3rd IAD, 2005.
71.	Masatoshi Nakajima, Miwako Ogata, Keiichi Hosaka, M Richard Foxton and Junji Tagami : Bonding durability to normal vs caries-affected dentin under hydrostatic pressure, 2004 IADR/AADR/CADR General Session, Honolulu, 2004.

国内講演発表:

1.	保坂啓一 : コンポジットレジン修復における革新とさらなる発展 ~デジタル技術と接着技術の融合~, 第63回広島県歯科医学会・第108回広島大学歯学会例会, 2024年11月.
2.	保坂啓一 : 接着歯学研究&臨床における最新の取り組み, 鹿児島大学大学院特別講義, 2024年7月.
3.	保坂啓一 : コンポジットレジン修復におけるインデックステクニックとマイクロスコープの融合:新たな歯科治療法への道, 日本顕微鏡歯科学会サテライトセミナー, 2024年6月.
4.	保坂啓一 : 保存修復学領域における臨床研究の最前線, 第160回日本歯科保存学会2024年度春季学術大会学会主導型シンポジウム, 2024年5月.
5.	内海雄太, 川野沙織, 松木優承, 渡邉佳一郎, 大毛健一郎, 伊田百美香, 米倉和秀, 田中栄二, 保坂啓一 : 上顎側切歯1歯欠損に対して，デジタルワークフローを活用したインジェクションテクニックにより，2層のダイレクトボンディングブリッジを行った審美修復症例, 日本歯科審美学会, 2023年12月.
6.	内海雄太, 松木優承, 渡邉佳一郎, 川野沙織, 井内智貴, 大毛健一郎, 伊田百美香, 米倉和秀, 保坂啓一 : 矯正歯科治療後，デジタルワークフローを活用したコンポジットレジンインジェクションテクニックにより犬歯誘導を獲得した1症例, 日本歯科保存学会 2023年秋季学術大会, 2023年11月.
7.	岡本梨沙, 細川義隆, 細川育子, 下山真弘, 尾崎和美, 保坂啓一 : TNF-αで刺激されたヒト歯根膜由来細胞の炎症性メディエーター発現に与えるcardamoninの影響, 日本歯科保存学会2023年度秋季学術大会(第159回), 2023年11月.
8.	椋由理子, 工藤保誠, 伊田百美香, 米倉和秀, 中島正俊, 保坂啓一 : 歯根膜繊維芽細胞に対するコンポジットレジンの細胞毒性の検討, 日本歯科保存学会 2023年秋季学術大会, 2023年11月.
9.	松木優承, 伊田百美香, 井内智貴, 内海雄太, 米倉和秀, 池田正臣, 保坂啓一 : 新規ワンステップユニバーサルボンドの象牙質接着性と吸水性および機械的強度の評価, 日本歯科保存学会 2023年秋季学術大会, 2023年11月.
10.	椋由理子, 工藤保誠, 保坂啓一 : 歯根膜線維芽細胞に対するコンポジットレジンの毒性の検討, 第65回歯科基礎医学会学術大会, 2023年9月.
11.	湯本華帆, 武川大輔, 鈴木善貴, 鴨居浩平, 大倉一夫, 小澤彩, 柴垣あかり, 富永賢, 保坂啓一, 松香芳三 : デジタル技術を用いて製作したミュージックスプリントの内面適合性に関する検討(第一報), 日本演奏芸術医学研究会, 2023年7月.
12.	湯本華帆, 鈴木善貴, 武川大輔, 大川敏永, 鴨居浩平, 小澤彩, 柴垣あかり, 新開瑞希, 谷脇竜弥, 富永賢, 保坂啓一, 松香芳三 : デジタル技術を利用したミュージックスプリントの内面適合性に関する評価法の検討, 四国歯学会雑誌, 2023年7月.
13.	三枝克啓, 中西正, 蔵本瞳, 細川義隆, 細川育子, 武川大輔, 保坂啓一 : Sudachitinがヒト歯髄細胞の炎症メディエーター発現に与える影響, 日本歯科保存学会 2023年度春季学術大会(第158回), 2023年6月.
14.	蔵本瞳, 中西正, 武川大輔, 三枝克啓, 保坂啓一 : Caffeic acid phenethyl ester (CAPE) がマウス骨芽細胞様細胞の組織修復関連因子発現に与える影響, 日本歯科保存学会 2023年度春季学術大会(第158回), 2023年6月.
15.	石原洋樹, 米倉和秀, 池田正臣, 中島正俊, 大槻昌幸, 島田康史, 保坂啓一 : 各種レジンセメントによる，歯冠象牙質ディスクおよびCAD/CAMコンポジットレジンディスクに対する象牙質微小引張り強さ, 日本歯科保存学会2023年春季学術大会, 2023年6月.
16.	下山真弘, 細川義隆, 細川育子, 保坂啓一 : TNF-αで刺激されたヒト口腔上皮細胞の炎症性メディエーター産生ならびに抗酸化タンパク質発現に対するErucinの影響, 日本歯科保存学会 2023年度春季学術大会(第158回), 2023年6月.
17.	三枝克啓, 中西正, 蔵本瞳, 武川大輔, 保坂啓一 : Interleukin-22 がヒト歯髄細胞の炎症性メディエーター発現に及ぼす影響, 第4回象牙質歯髄治療学会学術大会, 2023年5月.
18.	井内智貴, 米倉和秀, 伊田百美香, 元山祐太郎, 池田正臣, 浜田賢一, 中島正俊, 保坂啓一 : 2ステップセルフエッチングシステムのボンディング材の接着耐久性に及ぼすHEMAと10-MDPの影響についての検討, 第4回象牙質歯髄治療学会, 2023年5月.
19.	保坂啓一 : デジタル技術を応用した次世代の低侵襲白いつめもの治療, 令和4年度徳島大学大学院医歯薬学研究部公開シンポジウム, 2022年12月.
20.	伊田百美香, 米倉和秀, 井内智貴, Diana Fitri Muslimah, 池田正臣, 保坂啓一 : インジェクションモールディング法におけるクリアインデックス厚みがワンステップ接着システムの象牙質接着性能に及ぼす影響, 日本歯科保存学会 2022年秋季学術大会, 2022年11月.
21.	藤澤政紀, 三浦賞子, 磯貝知範, 新谷明一, 前野雅彦, 小峰太, 保坂啓一, 峯篤史, 佐藤洋平, 大久保力廣, 大槻昌幸 : AI活用による新しい口腔健康管理システム構築に関する研究予備解析結果について, 日本歯科審美学会, 2022年10月.
22.	三木仁志, 田代浩史, 田上順次, 高垣智博, 保坂啓一, 佐藤隆明, 畑山貴志, 島田康史 : コンポジットレジン直接修復による永久歯先天欠如への審美回復症例, 日本歯科審美学会, 2022年10月.
23.	椋由里子, 保坂啓一 : 正中離開に対する矯正治療とコンポジットレジン修復治療とのコンビネーション治療~7年経過長期症例~, 日本歯科審美学会, 2022年10月.
24.	髙木仲人, 髙木香, 保坂啓一 : ホワイトスポット病変の程度により治療法を使い分けた2症例, 日本歯科審美学会, 2022年10月.
25.	吉山昌宏, 保坂啓一, 妹尾祐介 : MI歯学とCAD/CAM修復の融合, 第3回象牙質歯髄治療学会学術大会, 2022年9月.
26.	保坂啓一 : 次世代のCR修復~最高の接着とデジタルガイドAdditive Approach~, 兵庫県歯科医学大会, 2022年7月.
27.	下山真弘, 細川義隆, 細川育子, 保坂啓一 : 6-MSITCはTNF-αが誘導するヒト口腔上皮由来細胞のIL-6およびCXCL10産生を抑制する, 日本歯科保存学会 2022年度春季学術大会(156回), 2022年6月.
28.	米倉和秀, 矢野隆章, 時実悠, 井内智貴, 安井武史, 保坂啓一 : テラヘルツ波イメージング法を用いた歯科保存修復領域における非破壊観察(第1報), 四国歯学会第58回例会, 2021年11月.
29.	保坂啓一 : 新しいホームホワイトニング治療を取り入れたSmile Enhancement戦略, 日本歯科審美学会第32回学術大会, 2021年11月.
30.	蔵本瞳, 中西正, 武川大輔, 細川由樹, 三枝克啓, 保坂啓一 : Caffeic acid phenethyl ester (CAPE)が歯髄細胞のVEGF産生に与える影響, 日本歯科保存学会2021年度秋季学術大会(第155回), 2021年10月.
31.	保坂啓一 : シングルシェードCRとスピーディ接着システムがもたらすCR修復の治療効率化, 2021年度秋季学術大会(第155回)共催セミナー, 2021年10月.
32.	畑山貴志, 中島正俊, 保坂啓一, 中川寿一, 田端倫子, 角保徳 : 新規低重合収縮レジンコア材の根管象牙質接着性能評価とSS-OCTを用いた根管内挙動解析, 第154回日本歯科保存学会, 2021年6月.
33.	元山裕太郎, 保坂啓一, 池田正臣, 中島正俊, 田上順次 : ハイドロキシアパタイトとの反応が，ワンステップセルフエッチングシステム硬化体の吸水性及び弾性率に及ぼす影響, 第154回日本歯科保存学会, 2021年6月.
34.	保坂啓一 : デジタルワークフローを活用したインジェクションテクニックによるコンポジットレジン修復の効率化, 第154回日本歯科保存学会学術大会教育講演, 2021年6月.
35.	保坂啓一 : ダイレクトボンディングの新潮流2021, 日本歯科審美学会特別セミナー(Web開催), 2021年5月.
36.	保坂啓一 : 象牙質接着の新ストラテジー, 第2回象牙質歯髄治療学会学術大会, 2021年5月.
37.	齋藤夏実, 三上理沙子, 水谷幸嗣, 武田浩平, 小湊広美, 城戸大輔, 池田裕一, 中川佳太, 竹村修, 上野剛史, 保坂啓一, 塙隆夫, 篠村多摩之, 岩田隆紀 : 糖尿病による歯科用インプラントのオッセオインテグレーションの低下, 日本歯周病学会会誌, Vol.63, 2021年5月.
38.	保坂啓一 : 新規構造発色フロアブルレジン(OCF-001)のヒト歯牙との色調調和性, 第153回日本歯科保存学会秋季学術大会, 2020年11月.
39.	保坂啓一 : 令和プロ研究「AI活用によるオンライン口腔健康度管理システムの構築」ー調査方法についてー, 日本歯科審美学会, 2020年10月.
40.	A. Tichy, K. Hosaka, M. Nakajima and Keiichi Hosaka : A comprehensive evaluation of dentin bonding durability of a novel two-step self-etch adhesive, 日本接着歯学会, Vol.38, No.3, 124, Sep. 2020.
41.	田代浩史, 三木仁志, 高垣智博, 畑山貴志, 保坂啓一, 田上順次 : コンポジットレジン直接修復による欠損部回復の臨床経過報告, 日本接着歯学会, 2020年9月.
42.	三木仁志, 田代浩史, 高垣智博, 畑山貴志, 保坂啓一, 田上順次 : コンポジットレジン直接修復による欠損部回復の生存解析, 日本接着歯学会, 2020年9月.
43.	保坂啓一 : トゥースウェア症例に対するSimplifiedコンポジットレジン修復 ∼デジタルワークフローとクリアマトリックスを活用した症例∼, 第151回日本歯科保存学会学術大会, 2020年6月.
44.	關奈央子, 水谷幸嗣, 保坂啓一, 駒田亘, 金澤学, 駒ヶ嶺友梨子, ジャネルモロス, 須永昌代, 川口陽子, 森尾郁子, 木下淳博 : 医歯学総合研究科歯学系大学院生対象の国際歯科臨床教育コース(Essential Expertise for Clinical Dentistry)に対する評価, 第84回口腔病学会学術大会, 2019年12月.
45.	塩谷頼誓, 高橋真広, 保坂啓一, 中島正俊, 田上順次 : 酸蝕象牙質モデルに対するDeproteinizing treatmentがワンステップシステムの接着耐久性に及ぼす影響, 日本歯科保存学会2019年度秋季学術大会, 2019年11月.
46.	脇智典, 峯篤史, 佐藤洋平, 小林幹宏, 保坂啓一, 高橋真広, 石川功和, 鍜治田忠彦, 渡邉清志, 江本朋弘, 齊木好太郎, 橋場千織, 石川明子, 武部純, 藤澤政紀 : 「審美を極める」シリーズセミナー(歯科医師・歯科技工士)の概括と成果, 第30回日本歯科審美学会学術大会, 2019年11月.
47.	保坂啓一 : デジタル時代の接着修復治療, 第38回日本接着歯学会学術大会, 2019年9月.
48.	Antonin TICHY, 保坂啓一, 池田正臣, 中島正俊, 田上順次 : 1ステップボンドを用いた改良型2ステップセルフエッチ接着システムの開発, 日本歯科保存学会学術大会, 2019年6月.
49.	田代浩史, 保坂啓一, 田上順次 : Tooth Wearによる機能的・審美的障害に対して直接法コンポジットレジン修復を行った1症例, 第150回日本歯科保存学会学術大会, 2019年6月.
50.	Pa Pa Kay Khine, Ahmad Abdou, 高垣智博, 保坂啓一, 中島正俊, 田上順次 : 二ケイ酸リチウムガラスセラミックスへの窩壁適合性に及ぼすシラン含有接着剤への温風乾燥の影響, 第150回日本歯科保存学会, 2019年6月.
51.	ドウィアンダニワユニスチ, 中島正俊, アブドウアフメド, 米倉和秀, 保坂啓一, 田上順次 : デュアルキュアアクチベーターと光照射時間が根管壁象牙質に対する接着強さに及ぼす影響, 第150回日本歯科保存学会, 2019年6月.
52.	Soe Yu Paing, Keiichi Hosaka, Masatoshi Nakajima and Junji Tagami : Effect of smear layerdeproteinizing with HOCl solution on micro-shear bond strengths of glass-ionomer cements to dentin, The 149th Meeting of The Japanese Society of Conservative Dentistry, Nov. 2018.
53.	石川杏子, 保坂啓一, 上野剛史, 中島正俊, 若林則幸, 田上順次 : 紫外線照射処理がレジンセメントの各種被着体に対する引張り接着強さに及ぼす効果, 第149回日本歯科保存学会学術大会, 2018年11月.
54.	長谷川真夕, 千葉彩香, 久野裕介, 荒川大輔, 佐藤健人, 保坂啓一, 池田正臣, 中島正俊, 田上順次 : マルチモード接着システムの象牙接着性能に及ぼすデュアルキュアアクチベーター前塗布の影響, 第149回日本歯科保存学会学術大会, 2018年11月.
55.	保坂啓一 : ダイレクトボンディングに1ステップ接着システムをどう活用するか? ―クリアフィル® ユニバーサルボンドQuick ERを用いた臨床―, 第149回日本歯科保存学会, 2018年11月.
56.	小林駿, 中島正俊, 保坂啓一, 佐藤健人, 田上順次 : 新規光重合型コンポジットレジン(ECM-001)のヒト歯牙との色調調和性へのフィラー粒径の影響, 第149回日本歯科保存学会学術大会, 2018年11月.
57.	アルマサビワリード, アーメドアブドゥ, 保坂啓一, 中島正俊, 田上順次 : フロワブルレジンの透過光特性に及ぼす水中浸漬およびサーマルストレスの影響, 第37回日本接着歯学会学術大会, 2018年11月.
58.	保坂啓一 : ダイレクトボンディングでどこまでできるのか, 日本歯科審美学会第29回学術大会アドバンストセミナー(保存)保存と補綴の境界, 2018年9月.
59.	小林駿, 保坂啓一, 佐藤健人, 中島正俊, 田上順次 : 新規光重合型コンポジットレジン(ECM001)のヒト歯牙との色調適合性の検討, 第148回日本歯科保存学会春季学術大会, 2018年6月.
60.	保坂啓一 : ダイレクトボンディング成功のための重要ポイント, 日本歯科審美学会セミナー「接着を活かして審美を極める ∼ダイレクトボンディングとジルコニア補綴, 2018年3月.
61.	保坂啓一 : プレゼンテーションがうまくなりたい，英語でも日本語でも∼ダイレクト修復を例に∼, 特別講義, 2018年3月.
62.	Keiichi Hosaka : Current update in adhesive systems, Thai Prosthodontic Association, Aug. 2017.
63.	關奈央子, 金澤学, 駒ヶ嶺友梨子, ジャネルモロス, 水谷幸嗣, 保坂啓一, 駒田亘, 須永昌代, 川口陽子, 森尾郁子, 木下淳博 : 東京医科歯科大学大学院における国際歯科臨床教育コースの導入と取り組み―第1報―, 第36回日本歯科医学教育学会総会・学術大会, 2017年7月.
64.	關奈央子, 金澤学, 駒ヶ嶺友梨子, ジャネルモロス, 水谷幸嗣, 保坂啓一, 駒田亘, 黒田真司, 須永昌代, 川口陽子, 森尾郁子, 木下淳博 : 本学大学院医歯学総合研究科における国際歯科臨床教育コースに対する評価, 第82回口腔病学会学術大会, 2017年7月.
65.	畑山貴志, 千葉彩香, 貝ノ瀬公典, 中島正俊, 保坂啓一, 若林則幸, 田上順次 : ポスト先端部と歯槽骨(皮質骨・海綿骨)の位置関係と荷重方向の違いがレジンコア築造歯の応力分布に与える影響, 第146回日本歯科保存学会学術大会, 2017年6月.
66.	米倉和秀, 保坂啓一, 田口敬太, 畑山貴志, 高橋真広, 神原啓介, 池田正臣, 中島正俊, 田上順次 : 根管象牙質に対するレジンコアシステムの接着性能に及ぼすエアブロー法の検討, 第35回日本接着歯学会学術大会, 2016年12月.
67.	井手久留美, 中島正俊, 保坂啓一, 高橋真広, 關奈央子, 田上順次 : バルクフィルフロアブルレジンのUltimate Tensile Strength に対する窩洞深さの影響, 日本歯科保存学会2016年度春季学術大会, 2016年9月.
68.	久野裕介, 荒岡大輔, 高橋真広, 保坂啓一, 中島正俊, 田上順次 : 親水性アミド系モノマーを含有した新規ワンステップセルフエッチングシステムの象牙質接着性能, 日本歯科保存学会2016年度春季学術大会, 2016年6月.
69.	永野大樹, 高橋真広, 中島正俊, 野田有佳里, 佐藤健人, 保坂啓一, 田上順次 : 異なる水中浸漬期間のコンポジットレジンのリペアに及ぼす表面処理法の影響, 日本保存学会第144回春季大会, 2016年6月.
70.	荒岡大輔, 田上順次, 保坂啓一, 高橋真広, 大槻昌幸 : 各種飲食物が歯の着色に及ぼす影響, 第26回日本歯科審美学会学術大会, 2015年11月.
71.	保坂啓一 : 歯のホワイトニング治療の展開 ∼審美的なレジン修復∼, 第26回日本歯科審美学会学術大会, 2015年11月.
72.	荒岡大輔, 佐藤健人, 高橋真広, 池田正臣, 保坂啓一, 中島正俊, 田上順次 : ユニバーサル表面処理材に対する光照射の有無がレジンセメントの接着性能に及ぼす影響, 日本歯科保存学会 2015年度春期学術大会(142回), 2015年6月.
73.	田口敬太, 畑山貴志, 佐藤健人, 吉峰斉昭, 高橋真広, 保坂啓一, 中島正俊, 田上順次 : 1ステップセルフエッチングシステムの根管象牙質接着性能に対する温風エアブローの効果, 第142回日本歯科保存学会2015年度春季学術大会, 2015年6月.
74.	畑山貴志, 中島正俊, 保坂啓一, 貝ノ瀬公典, 若林則幸, 田上順次 : 頬側咬頭に対する荷重方向の違いがレジンコア支台築造モデルにおける接合界面のせん断応力分散に及ぼす影響, 第142回日本歯科保存学会学術大会, 2015年6月.
75.	二階堂徹, 宇野滋, 久保至誠, 笹崎弘己, 佐藤かおり, 新海航一, 保坂啓一, 柵木寿男, 山本雄嗣, 吉川一志, 陸田明智, 矢谷博文, 桃井保子 : エビデンスと新発想のCR修復，マルチセンター方式によるコンポジットレジン修復の3年間の臨床成績, 第33回日本接着歯学会学術大会, 2014年12月.
76.	池田正臣, 上條真吾, 冨川紘一, 安江透, 保坂啓一, 鈴木哲也, 田上順次 : 1歯欠損症例に適した直接法接着ブリッジ, 日本歯科技工学会, 2014年9月.
77.	保坂啓一, 高橋真広, 中島正俊, 大槻昌幸, 田上順次 : MIとアンチエイジングを主題としたダイレクトベニア修復, 第25回日本歯科審美学会学術大会, 2014年9月.
78.	ママニーティーラポン, 高橋真広, 千葉彩香, 保坂啓一, 中島正俊, 田上順次 : 化学重合型ボンディング材を応用した新規デュアルキュア型レジンセメント「エステセム」の象牙質接着強さに及ぼす光照射の影響, 日本歯科保存学会平成26年度春季大会(140回), 2014年6月.
79.	高橋真広, ママニーティーラポン, 千葉彩香, 保坂啓一, 中島正俊, 田上順次 : 新規レジンセメントRely X Ultimateの象牙質接着強さに及ぼすコンタクトキュアの影響, 日本歯科保存学会平成26年度春季大会(140回), 2014年6月.
80.	野田有佳里, 高橋真広, ママニーティーラポン, 中島正俊, 池田正臣, 高垣智博, 保坂啓一, 田上順次 : 各種セラミックスへのレジンセメントの接着強さに及ぼす表面処理材の影響, 日本歯科保存学会平成26年度春季大会(140回), 2014年6月.
81.	保坂啓一, 田代浩史, 佐藤健人, 畑山貴志, 千葉彩香, 高橋真広, 中島正俊, 田上順次 : 超高速度撮影技術を用いたレジン―象牙質接着破壊の可視化, 第32回日本接着歯学会学術大会, 2013年.
82.	保坂啓一, 中島正俊, 篠田祐子, Taweesak Prasansuttiporn, Kunawarote Sitthikorn, 坂野若詠, 高橋真広, 岸川隆蔵, 田上順次 : 新規開発接着性レジンMTB200の象牙質接着性能, 第133回日本歯科保存学会, 2010年10月.
83.	保坂啓一, 中島正俊, 高橋真広, 駒田亘, 大竹志保, 三浦宏之, 池田正臣, 坂野若詠, 岸川隆蔵, 田上順次 : セルフエッチングシステムにおける吸水と機械的強度との関係, 第54回日本歯科理工学会学術講演会, 2009年.
84.	保坂啓一 : 親水性セルフエッチングプライマーの機械的性質に関する水の影響, 接着歯学会学術大会, 2007年.
85.	保坂啓一, ヤマウチモニカ, 緒方美和子, 池田正臣, 中島正俊, 田上順次 : All-in-One システムの象牙質接着性能に対する歯髄内圧の影響, 第46回日本歯科理工学会学術講演会, 2005年. (出版サイトへのリンク) ● Publication site (DOI): 10.14832/gsjsdmd.2005f.0.41.0 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.14832/gsjsdmd.2005f.0.41.0 (DOI: 10.14832/gsjsdmd.2005f.0.41.0)
86.	保坂啓一, モニカヤマウチ, 緒方美和子, 中島正俊, 田上順次 : 新規ワンステップボンディング材の歯質接着性能, 日本歯科保存学会, 2004年5月.

その他・研究会:

1.	保坂啓一 : 歯を守る! 光技術を活かした白いつめもの接着治療最前線, 徳島県立脇町高校サイエンスカフェ, 2024年10月.
2.	保坂啓一 : デジタル技術を活用したクリアインデックステクニックによるコンポジットレジン修復, 東北大学大学院歯科保存学分野セミナー, 2024年7月.
3.	保坂啓一, 渡邉佳一郎, 田中栄二, 田代浩史 : CRインジェクションモールディング法導入セミナー, ASO International Inc., 2023年8月.
4.	保坂啓一, 中島正俊, 渡邉佳一郎, 田中栄二, 鴨居浩平 : MI時代のコンポジットレジン修復戦略∼SLDPによる接着耐久性向上と，フルデジタルガイドインデックス活用∼．Dental Magazine．モリタ 184:30-33．2023．3月号, Dental Magazine, 2023年3月.
5.	保坂啓一 : 短時間でわかるコンポジットレジン修復メソッド, 東京都足立区歯科医師会, 2022年4月.
6.	保坂啓一 : さよなら銀歯, 群馬県歯科医師会, 2022年3月.
7.	保坂啓一 : 臨床に活きるコンポジットレジン修復と最新のトレンド2022, 香川県保険医協会, 2022年1月.
8.	保坂啓一 : 歯学部大学院教員としてのキャリア形成, 東京医科歯科大学統合国際教育機構主催第60回"Find-Your-Role-Model" Session, 2021年5月.
9.	保坂啓一 : Advanced Minimal Intervention デンティストリー ∼歯科衛生士が活躍する時代の幕明け∼, 公益社団法人東京都歯科衛生士会西北・南ブロック勉強会, 2021年2月.
10.	保坂啓一 : Men of CR, 東京医科歯科大学歯科同窓会講演, 2021年1月.
11.	保坂啓一 : グローバル活躍人材育成の教育現場から学会活動を考える, 日本歯科医学会連合主催フォーラム「歯学領域における国際的人材育成と学会活動」, 2021年1月.
12.	Keiichi Hosaka : Recent research findings in adhesive dentistry, Thammasat University Master Course Special Lecture, Nov. 2020.
13.	Keiichi Hosaka : Direct composite injection technique, Thammasat University Master Course Special Lecture, Nov. 2020.
14.	保坂啓一 : 最新MI保存修復治療2020, 公益社団法人東京都歯科衛生士会西北ブロック2019年度第1回勉強会, 2020年2月.
15.	Keiichi Hosaka : The Direct composite Restoration with a digital work flow for Tooth Wear Cases, Invited Lecture, Thammasat University Bangkok, Thailand, Feb. 2020.
16.	Keiichi Hosaka : Bond: with Esthetic Outcome, "Esthetic Beyond Frontier", Global Young Dental Leaders Meeting Movenpick BDMS Wellness Resort Bangkok, Thailand, Feb. 2020.
17.	Keiichi Hosaka : Esthetic direct composite restoration, Joint Hands-on Program Peking University Hospital of Stomatology Beijing, May 2019.
18.	菅原佳広, 保坂啓一 : 戦略的コンポジットレジン修復ー格差時代を生き抜く一つの方向性ー, 東京医科歯科大学歯科同窓会生涯研修Dr臨床セミナー, 2019年5月.
19.	保坂啓一 : ダイレクトボンディングがうまくなりたい ∼The Power of Direct Composite Restoration∼, 一般社団法人宇都宮市歯科医師会学術講演会, 2019年2月.
20.	Keiichi Hosaka : The Potentials and Limitations of Direct Composite Restorations -From Macroscopic and Microscipic Points of View-, Invited Lecture Thammasat University, Bangkok, Thailand, Jan. 2019.
21.	關奈央子, 保坂啓一, 駒田亘, 金澤学, 水谷幸嗣, 駒ヶ嶺友梨子, Janelle Moross, 森尾郁子 : 第一回外国人留学生フォーラム留学生の指導について, 日本歯科医学会連合主催第一回外国人留学生フォーラム, 2018年8月.
22.	保坂啓一 : そうだったのか!歯科衛生士が学ぶコンポジットレジン修復∼手を動かして理解するハンズオンコース∼, 東京都歯科衛生士会西北ブロック平成30年度ブロック勉強会, 2018年7月.
23.	保坂啓一 : 歯科衛生士が知っておきたい歯のホワイトニングとコンポジットレジン修復とのコンビネーション治療, 平成29年度第1回東京都歯科衛生士会西北ブロック勉強会, 2018年2月.
24.	Keiichi Hosaka : Direct Composite Restorations Based on Adhesive Technology, Invited Lecture Masaryk University, Brno, Czech republic, Dec. 2017.
25.	Keiichi Hosaka : Adhesive Dentistry meets Direct Composite Restoration, Invited Lecture Chulalongkorn University, Bangkok, Thailand, Oct. 2017.
26.	Keiichi Hosaka : Clinical Advances and Application of a new bulk fill composite resin, ベトナム歯科医師講演会, Apr. 2017.
27.	Keiichi Hosaka : Direct Composite Restoration Promotes Our Oral Health, Ho Chi Minh City, Vietnam, Apr. 2017.
28.	保坂啓一 : MiCDコンセプトが拡げるコンポジットレジン修復治療のさらなる可能性∼From Fillings toward Restorations∼, MiCD Symposium 日々の診療に役立つ9つのお話∼予防や審美の観点から∼, 2017年2月.
29.	保坂啓一 : さよなら銀歯, 東京医科歯科大学群馬県歯科同窓会学術講演会, 2017年1月.
30.	Keiichi Hosaka : Direct Composite Restorations, Invited Lecture Trisakty University, Jakarta, Indonesia, Jan. 2016.
31.	Keiichi Hosaka : Hands On Direct Veneer & Class 3-4 Restorations, Sminar Sehari Tentang Estetik Veneer, Hukum, Kode Etik Dan Perpajakan Jakarta, Indonesia, Jan. 2016.
32.	Keiichi Hosaka : Lecture Direct Veneer & Class 3-4 Restorations, Sminar Sehari Tentang Estetik Veneer, Hukum, Kode Etik Dan Perpajakan Jakarta, Indonesia, Jan. 2016.

報告書:

1.	冨士谷盛興, 保坂啓一, 吉川一志, 峯篤史, 友田篤臣, 川口陽子 : 逆転の発想!こうすれば留学は失敗しないー海外留学体験事例集ー, 日本歯科医学会連合, 2022年5月.

特許:

1.	粕谷玲奈, 坂田英武, 中島慶, 保坂啓一, 渡邉佳一郎, 鴨居浩平 : 歯科治療用補助器具，光硬化性組成物，及び歯科治療用補助器具の製造方法, 特願2024-083531 (2024年5月), 特許第2024-083531号 (2024年5月).
2.	渡邉佳一郎, 保坂啓一, 鴨居浩平, 田中栄二 : 歯科治療用インデックス，歯科治療用インデックス固定クリップ及び歯科治療セット, 特願2024-526462 (2023年5月), 特許第PCT/JP2024/016629号.
3.	保坂啓一, 本山靖治, 長谷川勇一 : 歯科治療用インデックスの作製方法，歯科治療システム，及び歯科治療用インデックス, 特願2021-132386 (2021年8月), 特開2023-26932 (2023年3月), 特許第2021-132386号 (2021年8月).

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

デジタル技術を活用したミュージックスプリントの革新：木管楽器奏者の口腔問題対策 (研究課題/領域番号: 24K03557 )
超小型THzチップを用いた高次メカノセンシングコンポジットレジン修復法の創出 (研究課題/領域番号: 23K09202 )
超高速・超高解像テラヘルツパルス・フェムト秒断層撮影による歯科医用工学革命 (研究課題/領域番号: 20KK0365 )
歯科用テラヘルツパルス波イメージング技術の開発と接着修復への応用 (研究課題/領域番号: 18K09571 )
時間・空間制御による接着歯学の超高速ダイナミクスの解明 (研究課題/領域番号: 15K11108 )
接着修復はいつ破壊するのか－破壊メカニズムの波動解析と予測診断技術への展開－ (研究課題/領域番号: 26462873 )
接着破壊メカニズムの３次元動的解析－疎水性接着システム開発への応用－ (研究課題/領域番号: 23792165 )
象牙質コラーゲンナノスペースを利用した新しい接着性レジンの開発 (研究課題/領域番号: 20791382 )
研究者番号（80451946）による検索

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教授 : 保坂 啓一

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学術論文(審査論文):

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

教授 : 保坂啓一