Tokushima University / Educator and Researcher Directory --- Ishizu, Masashi

Personal Web Page

https://orcid.org/0000-0003-1209-0878 (ORCID)

Field of Study

○	Epidemiology
○	Clinical Epidemiology
○	データサイエンス
○	Public Health

Subject of Study

○	NCDs (NAFLD, MAFLD, fatty liver, 循環器, electrocardiogram)
○	内分泌・代謝疾患領域を中心とした臨床疫学研究
○	地域医療連携システムならびに病院情報システムを対象としたデータベース研究
○	公的医療・保険データベースの有効活用に関する研究

Book / Paper

Academic Paper (Judged Full Paper):

1.	Taichi Unohara, Takeshi Watanabe, Kokichi Arisawa, Akari Matsuura, Kahori Kita, Yuka Torii, Masashi Ishizu, Sakurako Katsuura-Kamano, Tien Van Nguyen, Jun Otonari, Hiroaki Ikezaki, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Yoko Kubo, Takashi Matsunaga, Rieko Okada, Isao Oze, Hidemi Ito, Nobuaki Michihata, Yohko Nakamura, Shiroh Tanoue, Chihaya Koriyama, Sadao Suzuki, Takeshi Nishiyama, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Keiko Kondo, Takashi Tamura and Keitaro Matsuo : Dietary acid load and mortality: Results from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, Research Square, 2024. (Keyword) epidemiology / Dietary acid load / mortality rate / cardiovascular disease / cerebrovascular disease
2.	Naoko Miyagawa, Naoyuki Takashima, Akiko Harada, Aya Kadota, Keiko Kondo, Katsuyuki Miura, Nahomi Imaeda, Chiho Goto, Jun Otonari, Hiroaki Ikezaki, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Takashi Tamura, Yoko Kubo, Yasufumi Kato, Yuriko N. Koyanagi, Hidemi Ito, Nobuaki Michihata, Yohko Nakamura, Shiroh Tanoue, Rie Ibusuki, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Takeshi Watanabe, Masashi Ishizu, Asahi Hishida, Yoshikuni Kita, Kenji Wakai and Keitaro Matsuo : Dairy Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality Risk in A Large Japanese Population: A 12-Year Follow-Up of the J-MICC Study, Journal of Atherosclerosis and Thrombosis, 2024.
3.	Takeshi Watanabe, Tien Van Nguyen, Sakurako Katuura-Kamano, Kokichi Arisawa, Masashi Ishizu, Taichi Unohara, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Takashi Tamura, Yoko Kubo, Yasufumi Kato, Isao Oze, Hidemi Ito, Nobuaki Michihara, Yohko Nakamura, Shiroh Tanoue, Chihaya Koriyama, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashimα, Akiko Harada, Kenji Wakai and Keitaro Matsuo : The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort (J-MICC) Study., Cancer Research Communications, 2024. (Keyword) cancer / Metabolic phenotypes (Tokushima University Institutional Repository) ● Metadata: 119641 (Tokushima University Institutional Repository: 119641)
4.	Takeshi Watanabe, Kokichi Arisawa, Tien Van Nguyen, Masashi Ishizu, Sakurako Katsuura-Kamano, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Rieko Okada, Rie Ibusuki, Chihaya Koriyama, Sadao Suzuki, Takahiro Otani, Teruhide Koyama, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kenji Wakai and Keitaro Matsuo : Coffee and Metabolic Phenotypes: A Cross-sectional Analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, Vol.33, No.3, 620-630, 2023. (Summary) To date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population. We analyzed the data of 26,363 subjects (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Coffee consumption was assessed using a questionnaire. Metabolic Syndrome (MetS) was defined according to the Joint Interim Statement Criteria of 2009, using body mass index (BMI) instead of waist circumference. Subjects stratified by the presence or absence of obesity (normal weight: BMI <25 kg/m; obesity: BMI ≥25 kg/m) were classified by the number of MetS components (metabolically healthy: no components; metabolically unhealthy: one or more components) other than BMI. In multiple logistic regression analyses adjusted for sex, age, and other potential confounders, high coffee consumption (≥3 cups/day) was associated with a lower prevalence of MetS and metabolically unhealthy phenotypes both in normal weight (OR 0.83, 95% CI 0.76-0.90) and obese subjects (OR 0.83, 95% CI 0.69-0.99). Filtered/instant coffee consumption was inversely associated with the prevalence of MetS and metabolically unhealthy phenotypes, whereas canned/bottled/packed coffee consumption was not. The present results suggest that high coffee consumption, particularly filtered/instant coffee, is inversely associated with the prevalence of metabolically unhealthy phenotypes in both normal weight and obese Japanese adults. (Keyword) Humans / Cross-Sectional Studies / Coffee / Cohort Studies / Japan / Metabolic Syndrome / Obesity / Body Mass Index / Phenotype / Risk Factors (Link to Publication Site) ● Publication site (DOI): 10.1016/j.numecd.2022.12.019 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36710119 ● Search Scopus @ Elsevier (PMID): 36710119 ● Search Scopus @ Elsevier (DOI): 10.1016/j.numecd.2022.12.019 (DOI: 10.1016/j.numecd.2022.12.019, PubMed: 36710119)
5.	Tomoharu Kawano, Motohiro Aiba, Masashi Ishizu, Hiroyasu Mori, Munehide Matsuhisa, Seiichi Hashida, Tracey Colpitts and Toshihiro Watanabe : Molecular composition of adiponectin in urine is a useful biomarker for detecting early stage of diabetic kidney disease., The Journal of Medical Investigation : JMI, Vol.70, No.3.4, 464-470, 2023. (Summary) We previously developed two immune complex transfer enzyme immunoassays (ICT-EIA) to measure total adiponectin (T-AN) and high molecular weight adiponectin (H-AN) in urine and have verified their usefulness as biomarkers for diabetic kidney disease. In this study, we developed T-AN and H-AN assays using the sandwich EIA (Sand-EIA). The reactivities of Sand-EIAs were compared with ICT-EIAs by measuring size exclusion chromatography (SEC) fractions of urine and adiponectin standard. As a result, ICT-EIAs showed higher macromolecular specificity. We then analyzed the molecular profile of adiponectin in the urine of 5 patients with different eGFR stages by measuring SEC fractions of urine. The results showed that smaller adiponectin correlated relatively well with eGFR stage. Finally, because SEC is time-consuming, we investigated that the ratio of T-ANs by Sand-EIA and ICT-EIA could be a good indicator of the monomer adiponectin. The ratio was evaluated using 77 urine samples from patients with diabetes and showed a significant decrease at an earlier stage compared with other biomarkers. In conclusion, we demonstrated a new index to estimate monomer adiponectin in urine by using Sand-EIA and ICT-EIA, and urinary monomer adiponectin can be a good early indicator of deterioration of renal function in diabetic patients. J. Med. Invest. 70 : 464-470, August, 2023. (Keyword) Humans / Diabetic Nephropathies / Adiponectin / Sensitivity and Specificity / Sand / Biomarkers / Diabetes Mellitus (Tokushima University Institutional Repository) ● Metadata: 118797 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.464 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940533 ● Search Scopus @ Elsevier (PMID): 37940533 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.464 (Tokushima University Institutional Repository: 118797, DOI: 10.2152/jmi.70.464, PubMed: 37940533)
6.	Tien Van Nguyen, Kokichi Arisawa, Sakurako Katsuura-Kamano, Masashi Ishizu, Mako Nagayoshi, Rieko Okada, Asahi Hishida, Takashi Tamura, Megumi Hara, Keitaro Tanaka, Daisaku Nishimoto, Keiichi Shibuya, Teruhide Koyama, Isao Watanabe, Sadao Suzuki, Takeshi Nishiyama, Kiyonori Kuriki, Yasuyuki Nakamura, Yoshino Saito, Hiroaki Ikezaki, Jun Otonari, Yuriko N. Koyanagi, Keitaro Matsuo, Haruo Mikami, Miho Kusakabe, Kenji Takeuchi and Kenji Wakai : Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, PLoS ONE, Vol.17, No.7, e0269550, 2022. (Summary) The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population. We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35-69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined. During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04-2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78-1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05). MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population. (Keyword) Adenosine Triphosphate / Adult / Cholesterol / Cohort Studies / Female / Humans / Hyperglycemia / Japan / Male / Metabolic Syndrome / Neoplasms / Obesity / Risk Factors (Tokushima University Institutional Repository) ● Metadata: 117591 (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0269550 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35802721 ● Search Scopus @ Elsevier (PMID): 35802721 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0269550 (Tokushima University Institutional Repository: 117591, DOI: 10.1371/journal.pone.0269550, PubMed: 35802721)
7.	Asami Okada, Misuzu Yamada-Yamashita, Yukari Tominaga, Kyoka Jo, Hiroyasu Mori, Reiko Suzuki, Masashi Ishizu, Motoyuki Tamaki, Yuko Akehi, Yuichi Takashi, Daisuke Koga, Eisuke Shimokita, Fuminori Tanihara, Kiyoe Kurahashi, Sumiko Yoshida, Yukari Mitsui, Shiho Masuda, Itsuro Endo, Ken-ichi Aihara, Shoji Kagami, Masahiro Abe, Kevin Ferreri, Yoshio Fujitani, Munehide Matsuhisa and Akio Kuroda : Novel method utilizing bisulfite conversion with dual amplification-refractory mutation system polymerase chain reaction to detect circulating pancreatic β-cell cfDNA., Journal of Diabetes Investigation, Vol.13, No.7, 1140-1148, 2022. (Summary) We developed a novel method for detecting unmethylated insulin DNA in circulation that can be performed using a conventional real-time PCR system. This method would be useful for analyzing dynamic profiles of β-cells in human disease such as type 1 diabetes. (Tokushima University Institutional Repository) ● Metadata: 117206 (Link to Publication Site) ● Publication site (DOI): 10.1111/jdi.13806 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35396829 ● Search Scopus @ Elsevier (PMID): 35396829 ● Search Scopus @ Elsevier (DOI): 10.1111/jdi.13806 (Tokushima University Institutional Repository: 117206, DOI: 10.1111/jdi.13806, PubMed: 35396829)
8.	Yukari Mitsui, Akio Kuroda, Masashi Ishizu, Hiroyasu Mori, Kiyoe Kurahashi, Takeshi Kondo, Sumiko Yoshida, Yuko Akehi, Ken-ichi Aihara, Itsuro Endo, Masahiro Abe and Munehide Matsuhisa : Basal insulin requirement in patients with type 1 diabetes depends on the age and body mass index., Journal of Diabetes Investigation, Vol.13, No.2, 292-298, 2022. (Summary) T (Tokushima University Institutional Repository) ● Metadata: 116546 (Link to Publication Site) ● Publication site (DOI): 10.1111/jdi.13547 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33740836 ● Search Scopus @ Elsevier (PMID): 33740836 ● Search Scopus @ Elsevier (DOI): 10.1111/jdi.13547 (Tokushima University Institutional Repository: 116546, DOI: 10.1111/jdi.13547, PubMed: 33740836)
9.	Masashi Ishizu, Hiroyasu Mori, Mami Ohishi, Akio Kuroda, Y Akehi, Sumiko Yoshida, Ken-ichi Aihara, M Aiba, T Kawano, Seiichi Hashida and Munehide Matsuhisa : Urinary adiponectin excretion is an early predictive marker of the decline of the renal function in patients with diabetes mellitus., Journal of Diabetes and its Complications, Vol.35, No.4, 107848, 2021. (Summary) Since diabetes-associated kidney complication changes from diabetic nephropathy to diabetic kidney disease (DKD), more suitable biomarkers than urinary albumin are required. It has been hypothesized that urinary adiponectin (u-ADPN) is associated with the progression of DKD. We therefore evaluated the effectiveness of u-ADPN in predicting the decline of the renal function in patients with diabetes prior to end-stage renal disease. An ultrasensitive immune complex transfer enzyme immunoassay (ICT-EIA) was used to measure total and high molecular weight (HMW) adiponectin separately. We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (ΔeGFR). This 2-year prospective observational study included 201 patients with diabetes. These patients were divided into three groups according to their ΔeGFR: ≤-10 mL/min/1.73m, >-10 and ≤0 mL/min/1.73m, and >0 mL/min/1.73m. Jonckheere-Terpstra test showed that lower ΔeGFR was associated with higher u-HMW-ADPN (p = 0.045). In logistic regression analysis, u-HMW-ADPN was associated with ΔeGFR after adjusted age, sex, and basal eGFR. Urinary HMW-ADPN could predict a declining renal function in patients with diabetes. (Tokushima University Institutional Repository) ● Metadata: 115675 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jdiacomp.2021.107848 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33558151 ● Search Scopus @ Elsevier (PMID): 33558151 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jdiacomp.2021.107848 (Tokushima University Institutional Repository: 115675, DOI: 10.1016/j.jdiacomp.2021.107848, PubMed: 33558151)
10.	Yuichi Takashi, Shu Wakino, Hitoshi Minakuchi, Masashi Ishizu, Akio Kuroda, Hisato Shima, Manabu Tashiro, Keiko Miya, Kazuyoshi Okada, Jun Minakuchi, Shu Kawashima, Munehide Matsuhisa, Toshio Matsumoto and Seiji Fukumoto : Circulating FGF23 is not associated with cardiac dysfunction, atherosclerosis, infection or inflammation in hemodialysis patients., Journal of Bone and Mineral Metabolism, Vol.38, No.1, 70-77, 2020. (Summary) Fibroblast growth factor (FGF) 23 is a bone-derived hormone regulating serum inorganic phosphate (Pi) concentration. FGF23 is also involved in the development of chronic kidney disease (CKD)-mineral and bone disorder. Serum FGF23 concentration begins to increase early in the progression of CKD and can be remarkably high in hemodialysis patients with end-stage renal disease. It has been reported that high FGF23 concentration is a risk factor for cardiac dysfunction, atherosclerosis, infection or systemic inflammation in CKD patients. FGF23 was also shown to induce cardiac hypertrophy directly acting on cardiomyocytes. However, it is still controversial whether high FGF23 is causing cardiac dysfunction, atherosclerosis, infection or systemic inflammation in CKD patients. In the current study, we investigated whether FGF23 concentration is associated with cardiac dysfunction, atherosclerosis, infection or systemic inflammation in Japanese hemodialysis patients. We recruited 119 hemodialysis patients and examined the association between serum FGF23 concentration and several parameters concerning mineral metabolism, cardiac dysfunction, atherosclerosis, infection, and systemic inflammation. Serum FGF23 concentration was independently associated with serum calcium and Pi concentration (β = 0.276, p < 0.001; β = 0.689, p < 0.001). However, serum FGF23 concentration was not associated with parameters of cardiac dysfunction, atherosclerosis, infection, and systemic inflammation, either. Our results do not support the hypothesis that high FGF23 in dialysis patients is the cause of cardiac dysfunction, atherosclerosis, infection or systemic inflammation. (Link to Publication Site) ● Publication site (DOI): 10.1007/s00774-019-01027-7 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31420749 ● Search Scopus @ Elsevier (PMID): 31420749 ● Search Scopus @ Elsevier (DOI): 10.1007/s00774-019-01027-7 (DOI: 10.1007/s00774-019-01027-7, PubMed: 31420749)
11.	Toshihiro Watanabe, Yuki Fujimoto, Aya Morimoto, Mai Nishiyama, Akinori Kawai, Seiki Okada, Motohiro Aiba, Tomoharu Kawano, Mina Kawahigashi, Masashi Ishizu, Hiroyasu Mori, Munehide Matsuhisa, Akiko Hata, Makoto Funaki and Seiichi Hashida : Development of fully automated and ultrasensitive assays for urinary adiponectin and their application as novel biomarkers for diabetic kidney disease., Scientific Reports, Vol.10, No.1, 15869, 2020. (Summary) Glomerular filtration rate (GFR) and urinary albumin excretion rate (UAER) are used to diagnose and classify the severity of chronic kidney disease. Total adiponectin (T-AN) and high molecular weight adiponectin (H-AN) assays were developed using the fully automated immunoassay system, HI-1000 and their significance over conventional biomarkers were investigated. The T-AN and H-AN assays had high reproducibility, good linearity, and sufficient sensitivity to detect trace amounts of adiponectin in the urine. Urine samples after gel filtration were analyzed for the presence of different molecular isoforms. Low molecular weight (LMW) forms and monomers were the major components (93%) of adiponectin in the urine from a diabetic patient with normoalbuminuria. Urine from a microalbuminuria patient contained both high molecular weight (HMW) (11%) and middle molecular weight (MMW) (28%) adiponectin, although the LMW level was still high (52%). The amount of HMW (32%) and MMW (42%) were more abundant than that of LMW (24%) in a diabetic patient with macroalbuminuria. T-AN (r = - 0.43) and H-AN (r = - 0.38) levels showed higher correlation with estimated GFR (eGFR) than UAER (r = - 0.23). Urinary levels of both T-AN and H-AN negatively correlated with renal function in diabetic patients and they may serve as new biomarkers for diabetic kidney disease. (Tokushima University Institutional Repository) ● Metadata: 115617 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-020-72494-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32985540 ● Search Scopus @ Elsevier (PMID): 32985540 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-020-72494-6 (Tokushima University Institutional Repository: 115617, DOI: 10.1038/s41598-020-72494-6, PubMed: 32985540)
12.	Yuichi Takashi, Masashi Ishizu, Hiroyasu Mori, Kazuyuki Miyashita, Fumie Sakamoto, Naoto Katakami, Taka-Aki Matsuoka, Tetsuyuki Yasuda, Seiichi Hashida, Munehide Matsuhisa and Akio Kuroda : Circulating osteocalcin as a bone-derived hormone is inversely correlated with body fat in patients with type 1 diabetes., PLoS ONE, Vol.14, No.5, 2019. (Summary) The objective of the present study was to investigate the correlations between serum undercarboxylated osteocalcin (ucOC) or osteocalcin (OC) concentrations and %body fat, serum adiponectin and free-testosterone concentration, muscle strength and dose of exogenous insulin in patients with type 1 diabetes. We recruited 73 Japanese young adult patients with childhood-onset type 1 diabetes. All participants were receiving insulin replacement therapy. The correlations between logarithmic serum ucOC or OC concentrations and each parameter were examined. Serum ucOC and OC concentrations were inversely correlated with %body fat (r = -0.319, P = 0.007; r = -0.321, P = 0.006, respectively). Furthermore, multiple linear regression analyses were performed to determine whether or not serum ucOC or OC concentrations were factors associated with %body fat. Serum ucOC and OC concentrations remained significant factors even after adjusting for gender, HbA1c, body weight-adjusted total daily dose of insulin and duration of diabetes (β = -0.260, P = 0.027; β = -0.254, P = 0.031, respectively). However, serum ucOC and OC concentrations were not correlated with serum adiponectin or free-testosterone concentrations, muscle strength or dose of exogenous insulin. In conclusion, our study demonstrates the inverse correlation between serum ucOC or OC concentrations and body fat in patients with type 1 diabetes. (Tokushima University Institutional Repository) ● Metadata: 114023 (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0216416 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31050684 ● Search Scopus @ Elsevier (PMID): 31050684 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0216416 (Tokushima University Institutional Repository: 114023, DOI: 10.1371/journal.pone.0216416, PubMed: 31050684)
13.	Hiroyasu Mori, Akio Kuroda, Masashi Ishizu, Mami Ohishi, Yuichi Takashi, Yinhua Otsuka, Satoshi Taniguchi, Motoyuki Tamaki, Kiyoe Kurahashi, Sumiko Yoshida, Itsuro Endo, Ken-ichi Aihara, Makoto Funaki, Yuko Akehi and Munehide Matsuhisa : Association of accumulated advanced glycation end-products with a high prevalence of sarcopenia and dynapenia in patients with type 2 diabetes., Journal of Diabetes Investigation, 2019. (Summary) Advanced glycation end-products (AGEs), which are a major cause of diabetic vascular complications, accumulate in various tissues under chronic hyperglycemic conditions, as well as with aging in patients with diabetes. The loss of muscle mass and strength, so-called sarcopenia and dynapenia, has recently been recognized as a diabetic complication. However, the influence of accumulated AGEs on muscle mass and strength remains unclear. The present study aimed to evaluate the association of sarcopenia and dynapenia with accumulated AGEs in patients with type 2 diabetes. We recruited 166 patients with type 2 diabetes aged 30 years (mean age 63.2 ± 12.3 years; body mass index 26.3 ± 4.9 kg/m ; glycated hemoglobin 7.1 ± 1.1%). Skin autofluorescence as a marker of AGEs, limb skeletal muscle mass index, grip strength, knee extension strength and gait speed were assessed. Sarcopenia and dynapenia were observed in 7.2 and 13.9% of participants, respectively. Skin autofluorescence was significantly higher in patients with sarcopenia and dynapenia. Skin autofluorescence was the independent determinant for skeletal muscle mass index, grip strength, knee extension strength, sarcopenia and dynapenia. Accumulated AGEs could contribute to reduced muscle mass and strength, leading to sarcopenia and dynapenia in patients with type 2 diabetes. (Tokushima University Institutional Repository) ● Metadata: 114022 (Link to Publication Site) ● Publication site (DOI): 10.1111/jdi.13014 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30677242 ● Search Scopus @ Elsevier (PMID): 30677242 ● Search Scopus @ Elsevier (DOI): 10.1111/jdi.13014 (Tokushima University Institutional Repository: 114022, DOI: 10.1111/jdi.13014, PubMed: 30677242)
14.	Tirani Bahari, Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Keisuke Miki, Masashi Ishizu and Kokichi Arisawa : Nutrient-derived dietary patterns and their association with metabolic syndrome in a Japanese population, Journal of Epidemiology, Vol.28, No.4, 194-201, 2018. (Summary) Nutrients have been proposed to be related to metabolic syndrome (MetS). The aims of this study were to identify dietary patterns that correlated with several nutrients using reduced rank regression (RRR) and to examine the association between extracted dietary patterns and prevalence of MetS in a Japanese population. The study population comprised 1,092 Japanese men and women (35-69 years old) who had participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima Prefecture. Dietary patterns were derived with RRR using 46 food items as predictors and six established nutrients (potassium, calcium, vitamin D, vitamin C, insoluble dietary fiber, and carotene) as response variables. Associations between extracted dietary patterns and MetS were then examined with logistic regression models. Among the six dietary patterns, dietary pattern 1 (DP1) explained the largest proportion (60.1%) of variance in the six nutrients. Therefore, only DP1 was selected for further analysis. DP1 was characterized by high intake frequency of vegetables, fruits, fish and small fish, natto (fermented soybeans), and deep-fried tofu. After adjustment for potential confounders, significant inverse associations were found between DP1 score and MetS (odds ratio [OR] for each quartile: 1.00, 0.58, 0.60, 0.52; P = 0.02); DP1 and high blood pressure (P = 0.0002); and DP1 and high blood glucose (P = 0.02). A dietary pattern characterized by high intake of vegetables, fruits, fish and small fish, natto, and deep-fried tofu was associated with reduced prevalence of MetS in a Japanese population. (Keyword) Adult / Aged / Cohort Studies / Feeding Behavior / Female / Food / Humans / Japan / Male / Metabolic Syndrome / Middle Aged / Prevalence (Tokushima University Institutional Repository) ● Metadata: 110919 (Link to Publication Site) ● Publication site (DOI): 10.2188/jea.JE20170010 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29151477 ● Search Scopus @ Elsevier (PMID): 29151477 ● Search Scopus @ Elsevier (DOI): 10.2188/jea.JE20170010 (Tokushima University Institutional Repository: 110919, DOI: 10.2188/jea.JE20170010, PubMed: 29151477)
15.	Sakurako Katsuura-Kamano, Hirokazu Uemura, Miwa Yamaguchi, Mariko Nakamoto, Tirani Bahari, Keisuke Miki, Masashi Ishizu, Fusakazu Sawachika and Kokichi Arisawa : Dietary calcium intake is associated with serum high-sensitivity C-reactive protein level in the general Japanese population, Journal of Clinical Biochemistry and Nutrition, Vol.62, No.1, 89-93, 2018. (Summary) The beneficial effects of dietary calcium intake on high-sensitivity C-reactive protein levels, a risk factor of cardiovascular disease, have not been fully elucidated. This study investigated the associations between dietary calcium intake and serum high-sensitivity C-reactive protein levels in the general Japanese population. We analyzed the data of 2,019 subjects (1,194 men and 825 women) aged 35 to 69 years in a cross-sectional study of the Japan Multi-Institutional Collaborative Cohort Study. Nutrients intake including calcium were estimated using a validated food-frequency questionnaire. Analysis using a general linear model revealed that dietary calcium intake was inversely associated with serum high-sensitivity C-reactive protein levels ( for trend <0.001) after adjustment for age, sex, research group, leisure-time physical activity, smoking habit, drinking habit, dietary intakes (energy, dietary fiber, saturated fatty acids and vitamin D) and menopausal status. The association was slightly attenuated after additional adjustment for body mass index; however, remained significant ( for trend = 0.008). There were no significant interactions between dietary calcium intakes and sex, body mass index, or vitamin D intake for high-sensitivity C-reactive protein levels. This study have demonstrated that dietary calcium intake was inversely associated with serum high-sensitivity C-reactive protein levels in the general population. (Tokushima University Institutional Repository) ● Metadata: 111900 (Link to Publication Site) ● Publication site (DOI): 10.3164/jcbn.17-48 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29371759 ● CiNii @ National Institute of Informatics (CRID): 1390282679650033664 ● Search Scopus @ Elsevier (PMID): 29371759 ● Search Scopus @ Elsevier (DOI): 10.3164/jcbn.17-48 (Tokushima University Institutional Repository: 111900, DOI: 10.3164/jcbn.17-48, PubMed: 29371759, CiNii: 1390282679650033664)
16.	Hirokazu Uemura, AHMAD AMMAR GHAIBEH, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Bahari Tirani, Masashi Ishizu, Hiroki Moriguchi and Kokichi Arisawa : Systemic inflammation and family history in relation to the prevalence of type 2 diabetes based on an alternating decision tree, Scientific Reports, Vol.7, 45502, 2017. (Summary) To investigate unknown patterns associated with type 2 diabetes in the Japanese population, we first used an alternating decision tree (ADTree) algorithm, a powerful classification algorithm from data mining, for the data from 1,102 subjects aged 35-69 years. On the basis of the investigated patterns, we then evaluated the associations of serum high-sensitivity C-reactive protein (hs-CRP) as a biomarker of systemic inflammation and family history of diabetes (negative, positive or unknown) with the prevalence of type 2 diabetes because their detailed associations have been scarcely reported. Elevated serum hs-CRP levels were proportionally associated with the increased prevalence of type 2 diabetes after adjusting for probable covariates, including body mass index and family history of diabetes (P for trend = 0.016). Stratified analyses revealed that elevated serum hs-CRP levels were proportionally associated with increased prevalence of diabetes in subjects without a family history of diabetes (P for trend = 0.020) but not in those with a family history or with an unknown family history of diabetes. Our study demonstrates that systemic inflammation was proportionally associated with increased prevalence of type 2 diabetes even after adjusting for body mass index, especially in subjects without a family history of diabetes. (Tokushima University Institutional Repository) ● Metadata: 112349 (Link to Publication Site) ● Publication site (DOI): 10.1038/srep45502 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28361994 ● Search Scopus @ Elsevier (PMID): 28361994 ● Search Scopus @ Elsevier (DOI): 10.1038/srep45502 (Tokushima University Institutional Repository: 112349, DOI: 10.1038/srep45502, PubMed: 28361994)

Proceeding of International Conference:

1.	Nguyen Van Tien, Kokichi Arisawa, Sakurako Kamano, Takeshi Watanabe and Masashi Ishizu : Association of metabolic syndrome and metabolically unhealthy obesity with cancer mortality, Asia Pacific Conference 2022, Beppu, Dec. 2022.
2.	Akio Kuroda, Misuzu Yamada, Yuichi Takashi, Mami Ohishi, Hiroyasu Mori, Masashi Ishizu, Reiko Suzuki, Yinhua Otsuka, Yukari Tominaga and Munehide Matsuhisa : Detection of Vascular Endothelial Cell DNA in the Circulation Using Dual Amplification Refractory Mutation System PCR., American Diabetes Association 79th Scientific Sessions, San Francisco, Jun. 2019.
3.	Munehide Matsuhisa, Hiroyasu Mori, Mami Ohishi, Masashi Ishizu, Reiko Suzuki, Ineko Takikawa, Satoshi Taniguchi, Motoyuki Tamaki, Yuko Akehi, Kiyoe Kurahashi, Sumiko Yoshida, Itsuro Endo, Ken-ichi Aihara, Makoto Funaki and Akio Kuroda : The risk factors for rapid decline of renal function in Japanese patients with diabetes mellitus, American Diabetes Association 78th Scientific Sessions, Orlando, Jun. 2018.

Proceeding of Domestic Conference:

1.	山本真悠子, 髙士祐一, Masashi Ishizu, 豊川恭子, 永田大, 牟田芳実, 横溝久, 関口男, 前田泰孝, 南昌江, 加藤明日香 and 川浪大治 : 2型糖尿病におけるセルフスティグマと糖尿病合併症の関連, 第39回日本糖尿病合併症学会, Oct. 2024.
2.	Masashi Ishizu, Akio Kuroda, 鈴木麗子 and Munehide Matsuhisa : 心電図異常における糖尿病の意義の検討 -令和3年度徳島県市町村国保特定健診・後期高齢者医療健診データの解析結果-, 第24回日本糖尿病インフォマティクス学会年次学術集会, Aug. 2024.
3.	山本真悠子, 髙士祐一, 加藤明日香, Masashi Ishizu, 豊川恭子, 永田大, 牟田芳実, 横溝久, 関口男, 前田泰孝, 南昌江 and 川浪大治 : 2型糖尿病におけるセルフスティグマと糖尿病合併症の関連, 第31回西日本肥満研究会, Jul. 2024.
4.	山本真悠子, Yuichi Takashi, 加藤明日香, Masashi Ishizu, 豊川恭子, 牟田芳実, 横溝久, 関口男, 前田泰孝, 南昌江 and 川浪大治 : 2型糖尿病におけるセルフスティグマと糖尿病合併症に関する単施設検討, 第67回日本糖尿病学会年次学術集会, May 2024.
5.	Sakurako Kamano, Masashi Ishizu and Takeshi Watanabe : 出生体重と日本人中高年の不安特性との関連:J-MICC Study 徳島地区調査, 第34階日本疫学会学術総会, Feb. 2024.
6.	Masashi Ishizu and Munehide Matsuhisa : 心電図異常に関わる背景因子の検討-令和2年度徳島県市町村国保特定健診・後期高齢者医療健診データの解析, 第8回日本糖尿病・生活習慣病ヒューマンデータ学会, Dec. 2023.
7.	Akio Kuroda, Asami Okada, Hiroyasu Mori, 冨永ゆかり, Masashi Ishizu and Munehide Matsuhisa : 循環血中遊離 DNA を標的とした血管内皮細胞傷害の検出, 第38回日本糖尿病合併症学会, Oct. 2023.
8.	Sakurako Kamano, Kokichi Arisawa, Masashi Ishizu, Takeshi Watanabe and Nguyen Van Tien : 大豆製品およびイソフラボン摂取量と糖尿病罹患との関連:J-MICC Study, 第33回日本疫学会学術総会, Feb. 2023.
9.	Takeshi Watanabe, Kokichi Arisawa, Tien Van Nguyen, Masashi Ishizu and Sakurako Kamano : Coffee and metabolic phenotypes: A cross-sectional analysis of the Japan multi-institutional collaborative cohort (J-MICC) study, The 33rd annual scientific meeting of the Japan Epidemiological Association, Feb. 2023.
10.	Sakurako Kamano, Kokichi Arisawa, Masashi Ishizu, Takeshi Watanabe, NGUYEN VAN TIEN and for the J-MICC Study Group : 朝食欠食および睡眠時間とメタボリック症候群との関連:J-MICC Study, 第264回徳島医学会学術集会, Feb. 2022.
11.	Tien Van Nguyen, Kokichi Arisawa, Sakurako Kamano, Takeshi Watanabe, Masashi Ishizu and for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group : Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: Results of prospective cohort study in Japanese population, 第264回徳島医学会学術集会, Feb. 2022.
12.	Tien Van Nguyen, Kokichi Arisawa, Sakurako Katsuura-Kamano, Takeshi Watanabe, Masashi Ishizu and for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group : Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality, 第32回日本疫学会学術総会, Jan. 2022.
13.	Sakurako Kamano, Kokichi Arisawa, Masashi Ishizu, Takeshi Watanabe, NGUYEN TIEN VAN and for the J-MICC Study Group : 大豆製品およびイソフラボン摂取量と全死亡・がん死亡との関連:J-MICC Study, 第32回日本疫学会学術総会, Jan. 2022.
14.	Akio Kuroda, Masashi Ishizu, 鶴尾美穂, Hiroyasu Mori, 明比祐子, 岡本美鈴, 鈴木麗子, 寺澤敏秀 and Munehide Matsuhisa : 持続グルコースモニタリングの推定HbA1c値と実測HbA1c値との解離に関する検討, 第21回日本糖尿病インフォマティクス学会年次学術集会, Aug. 2021.
15.	Akio Kuroda, Masashi Ishizu, 鶴尾美穂, Hiroyasu Mori, 明比祐子, 岡本美鈴, 鈴木麗子, 寺澤敏秀 and Munehide Matsuhisa : 持続グルコースモニタリングの推定HbA1c値と実測HbA1c値との解離に関する検討, 日本糖尿病学会中国四国地方会第58総会, Oct. 2020.
16.	Masashi Ishizu, Hiroyasu Mori, 明比祐子, Akio Kuroda, Motoyuki Tamaki, Sumiko Yoshida, Ken-ichi Aihara, 藍場元弘, 河野友晴, Seiichi Hashida and Munehide Matsuhisa : 糖尿病性腎症における尿アディポネクチンの意義(第2報), 日本糖尿病学会中国四国地方会第58総会, Oct. 2020.
17.	Akio Kuroda, Masashi Ishizu, 鶴尾美穂, Hiroyasu Mori, 明比祐子, 岡本美鈴, 鈴木麗子, 寺澤敏秀 and Munehide Matsuhisa : 持続グルコースモニタリングの推定HbA1c値と実測HbA1c値との解離に関する検討, 第20回日本糖尿病情報学会年次学術集会, Sep. 2020.
18.	三井由加里, Akio Kuroda, Masashi Ishizu, 桝田志保, Kiyoe Kurahashi, Sumiko Yoshida, 明比祐子, Itsuro Endo, Ken-ichi Aihara, Masahiro Abe and Munehide Matsuhisa : 頻回インスリン注射療法下の1型糖尿病患者における基礎インスリン比率の検討, 日本糖尿病学会中国四国地方会第57回総会, Dec. 2019.
19.	鶴尾美穂, 住友正治, 小松まち子, 大島康志, 坂東智子, Hiroyasu Mori, Masashi Ishizu, 髙橋保子, Ken-ichi Aihara, Munehide Matsuhisa and 宇都宮正登 : 徳島市医師会糖尿病腎症重症化予防パイロット事業後アンケート結果, 日本糖尿病学会中国四国地方会第57回総会, Dec. 2019.
20.	Akio Kuroda, 鶴尾美穂, Masashi Ishizu and Munehide Matsuhisa : Time-In-RangeとHbA1cとの関連∼HbA1cと組み合わせる血糖管理方法∼, 第19回日本先進糖尿病治療研究会・第17回1型糖尿病研究会, Nov. 2019.
21.	三井由加里, Akio Kuroda, Masashi Ishizu, Kiyoe Kurahashi, Sumiko Yoshida, 明比祐子, Itsuro Endo, Ken-ichi Aihara, Masahiro Abe and Munehide Matsuhisa : 頻回インスリン注射療法下の1型糖尿病患者における基礎インスリン比率の検討, 第19回日本先進糖尿病治療研究会・第17回1型糖尿病研究会, Nov. 2019.
22.	Masashi Ishizu, Hiroyasu Mori, Mami Ohishi, 鈴木麗子, 岡本美鈴, 明比祐子, Akio Kuroda, Motoyuki Tamaki, Yuichi Takashi, Sumiko Yoshida, Ken-ichi Aihara, 藍場元弘, 河野友晴, Seiichi Hashida and Munehide Matsuhisa : 糖尿病性腎臓病における尿中アディポネクチン排泄の臨床的意義, 第40回日本肥満学会・第37回日本肥満症治療学会, Nov. 2019.
23.	Masashi Ishizu, 鶴尾美穂, 豊崎纏, Ken-ichi Aihara, 坂東智子, 住友正治, 古川浩, 宮本泰文, 小松まち子, 大島康志, 桜井えつ, 若槻真吾, 岡川和人, 林正, 松村光博, 小川紘一, 安岡正治, 細井恵美子, 丸岡重代, 西岡恵子, 髙橋保子, Hiroyasu Mori, Munehide Matsuhisa and 宇都宮正登 : 徳島市医師会糖尿病腎症重症化予防パイロット事業の報告, 第19回日本糖尿病情報学会年次学術集会, Aug. 2019.
24.	鈴木麗子, Hiroyasu Mori, Masashi Ishizu, Yuu Tamaki, Satoshi Taniguchi, Akio Kuroda and Munehide Matsuhisa : スマートスピーカーを活用した個別化糖尿病自己管理支援システムの開発糖尿病患者の行動変容を目指して, 第19回日本糖尿病情報学会年次学術集会, Aug. 2019.
25.	鶴尾美穂, 豊﨑纏, 小松まち子, 住友正治, 大島康志, Ken-ichi Aihara, Hiroyasu Mori, Masashi Ishizu, 岡川和人, 小川絋一, 古川浩, 桜井えつ, 林正, 坂東智子, 細井恵美子, 松村光輝, 宮本泰文, 保岡正治, 高橋保子, 丸岡重代, 西岡恵子, 宇都宮正登 and Munehide Matsuhisa : 徳島市医師会糖尿病腎症重症化予防パイロット事業の取組, 第62回日本糖尿病学会年次学術集会, May 2019.
26.	Masashi Ishizu, Hiroyasu Mori, Mami Ohishi, 鈴木麗子, 岡本美鈴, 明比祐子, Akio Kuroda, Motoyuki Tamaki, Yuichi Takashi, Sumiko Yoshida, Ken-ichi Aihara, 藍場元弘, 河野友晴, Seiichi Hashida and Munehide Matsuhisa : 糖尿病性腎臓病における尿中アディポネクチン排泄率の臨床的意義の検討, 第62回日本糖尿病学会年次学術集会, May 2019.
27.	Munehide Matsuhisa, Hiroyasu Mori, Satoshi Taniguchi, Masashi Ishizu, 明比祐子, Yuu Tamaki and Akio Kuroda : 徳島県での地域医療連携基盤の構築とデータ利活用への試み, 第3回日本糖尿病・生活習慣病ヒューマンデータ学会シンポジウム3, Dec. 2018.
28.	Masashi Ishizu, Hiroyasu Mori, Mami Ohishi, 鈴木麗子, 明比祐子, Akio Kuroda, Motoyuki Tamaki, Yuichi Takashi, Sumiko Yoshida, Ken-ichi Aihara, 藍場元弘, 河野友晴, Seiichi Hashida and Munehide Matsuhisa : 糖尿病性腎臓病における尿アディポネクチンの意義, 日本糖尿病学会中国四国地方会第56回総会, Oct. 2018.
29.	Hiroyasu Mori, Akio Kuroda, Masashi Ishizu, Yuichi Takashi, Satoshi Taniguchi, Motoyuki Tamaki, 明比祐子 and Munehide Matsuhisa : 2型糖尿病患者における肥満と筋傷害との関連の検証, 第39回日本肥満学会, Oct. 2018.
30.	Yuichi Takashi, Masashi Ishizu, Shu Wakino, 水口斉, 島久登, 田代学, 宮恵子, 水口潤, Akio Kuroda, Toshio Matsumoto, Munehide Matsuhisa and Seiji Fukumoto : 血液透析患者における心不全・動脈硬化・感染のリスク因子としてのFGF23, 第18回日本内分泌学会四国支部学術集会, Sep. 2018.
31.	Hiroyasu Mori, Michiko Araki, Akio Kuroda, Masashi Ishizu, Yuichi Takashi, Satoshi Taniguchi, Kiyoe Kurahashi, Sumiko Yoshida, Itsuro Endo, Ken-ichi Aihara, Motoyuki Tamaki, 明比祐子 and Munehide Matsuhisa : 1型糖尿病患者の血清IGF-1とサルコペニア合併に関する横断的検証, 第18回日本内分泌学会四国支部学術集会, Sep. 2018.
32.	Yuichi Takashi, Masashi Ishizu, Hiroyasu Mori, Akio Kuroda and Munehide Matsuhisa : 骨産生ホルモンであるオステオカルシンは1型糖尿病患者の体脂肪を制御する, 第118回日本内科学会四国地方会, Jun. 2018.
33.	Akio Kuroda, Misuzu Yamada, 冨永ゆかり, 鈴木麗子, Motoyuki Tamaki, 明比祐子, Yuichi Takashi, Masashi Ishizu, 古賀大輔, Issei Imoto, Kiyoe Kurahashi, Sumiko Yoshida, Itsuro Endo, Ken-ichi Aihara, Masahiro Abe, Kevin Ferreri and Munehide Matsuhisa : 膵β細胞特異的PCRによる膵β細胞死の検出, 第61回日本糖尿病学会年次学術集会, May 2018.
34.	Yuichi Takashi, Masashi Ishizu, Hiroyasu Mori, 宮下和幸, 坂本扶美枝, 片上直人, 松岡孝昭, 安田哲行, Seiichi Hashida, Akio Kuroda and Munehide Matsuhisa : 骨産生ホルモンucOCは1型糖尿病患者の体脂肪率と関係する, 第61回日本糖尿病学会年次学術集会, May 2018.
35.	Masashi Ishizu, Yuichi Takashi, 脇野修, 水口斉, 田代学, 宮恵子, Yoshihiko Noma, 小松まち子, 水口潤, Akio Kuroda, Seiji Fukumoto and Munehide Matsuhisa : 血液透析患者における糖尿病をはじめとする動脈硬化リスク因子の検討, 第61回日本糖尿病学会年次学術集会, May 2018.
36.	Hiroyasu Mori, 鈴木麗子, 瀧川稲子, Masashi Ishizu, Mami Ohishi, Satoshi Taniguchi, 明比祐子, Akio Kuroda and Munehide Matsuhisa : 糖尿病腎症の急速進行に関連するリスク因子の検証:前向き観察研究, 第61回日本糖尿病学会年次学術集会, May 2018.
37.	Motoyuki Tamaki, Yuichi Takashi, Toshiki Otoda, Seiji Fukumoto, Akio Kuroda, 明比祐子, Hiroyasu Mori, Satoshi Taniguchi, 鈴木麗子, Misuzu Yamada, Masashi Ishizu, Mami Ohishi, 白神敦久, Ken-ichi Aihara, Makoto Funaki and Munehide Matsuhisa : かかりつけ患者に対するSGLT2阻害薬の投与開始タイミングの特徴と投与開始後の体重・eGFR・ALT・脂質代謝の変化, 第61回日本糖尿病学会年次学術集会, May 2018.
38.	Mami Ohishi, Hiroyasu Mori, 鈴木麗子, 明比祐子, Akio Kuroda, Motoyuki Tamaki, Satoshi Taniguchi, Masashi Ishizu, Hiroshi Sakaue and Munehide Matsuhisa : 急速進行性糖尿病腎症に関連するリスク因子の検討, 日本糖尿病学会中国四国地方会第55回総会抄録集, Nov. 2017.

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