Tokushima University / Educator and Researcher Directory --- Wakino, Shu

Personal Web Page

https://researchmap.jp/wakino-shu (researchmap)

Field of Study

○	Nephrology, Nutrition, Endocrinology and Metabolism

Subject of Study

○	慢性腎臓病, 血液透析, エネルギー代謝

Book / Paper

Book:

1.	加藤明彦 (内科学), Yutaka Taketani, Shu Wakino and 北島幸枝 : 腎臓栄養学, 朝倉書店, May 2024. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1130581611739888006 (CiNii: 1130581611739888006)

Academic Paper (Judged Full Paper):

1.	MATSUDA Noritake, Hideki Otsuka, Ryosuke Kasai, Tamaki Otani, BOLLOS CHRISTINE ANNE LEAH LOCSIN, Shota Azane, Yamato Kunikane, Youichi Otomi, UEKI Yuya, Mana Okabe, Masafumi Amano, Masanori Tamaki, Shu Wakino, Shoichiro Takao and Masafumi Harada : Quantitative evaluation of 67Gacitrate scintigraphy in the management of nephritis, Scientific Reports, Vol.14, No.16313, 16313, 2024. (Summary) In Ga-citrate scintigraphy (Ga-S), visual assessment is used by evaluating renal-uptake comparison with liver and spine and is simple and objective. We adopted the standardized uptake value (SUV) for Ga-citrate and proposed two quantitative indices, active nephritis volume (ANV) and total nephritis uptake (TNU). This study clarified the utility of new Ga-S-based quantitative indices in nephritis management. Before SUV measurement, the Becquerel calibration factor of Ga-citrate was obtained using a phantom experiment. Seventy patients who underwent SPECT/CT imaging were studied. SUV, ANV, and TNU were calculated using a quantitative analysis software for bone SPECT. SUV, ANV, and TNU were analyzed using the (1) threshold method (set 40%) and constant-value method for (2) vertebral SUV, and (3) vertebral SUV. ROC analysis was used to evaluate SUV, ANV, and TNU diagnostic abilities to distinguish nephritis presence and absence as well as interstitial nephritis (IN) and non-IN. The area under the curve (AUC) for nephritis presence or absence had a good value (0.80) for SUV (1), ANV (3), and TNU (3). The AUC for differentiation between IN and non-IN groups had a good value (0.80) for SUV (1). Thus, the new Ga-S-based quantitative indices were useful to evaluate nephritis and distinguish IN and non-IN. (Keyword) Humans / Male / Female / Middle Aged / Gallium Radioisotopes / Aged / Gallium / Adult / Nephritis / Citrates / ROC Curve / Aged, 80 and over / Radiopharmaceuticals / Single Photon Emission Computed Tomography Computed Tomography (Tokushima University Institutional Repository) ● Metadata: 119491 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-024-66823-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39009630 ● CiNii @ National Institute of Informatics (CRID): 1050019590267929472 ● Search Scopus @ Elsevier (PMID): 39009630 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-024-66823-2 (Tokushima University Institutional Repository: 119491, DOI: 10.1038/s41598-024-66823-2, PubMed: 39009630, CiNii: 1050019590267929472)
2.	Kazuhiro Hasegawa, Masanori Tamaki, Yusuke Sakamaki and Shu Wakino : Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1., International Journal of Molecular Sciences, Vol.25, No.12, 2024. (Summary) overexpression preserved mitoribosomal function, suggesting its protective role in DN. (Keyword) Animals / Male / Mice / Diabetic Nephropathies / Kidney Tubules, Proximal / Mice, Inbred C57BL / Mice, Knockout / Mitochondria / Nicotinamide-Nucleotide Adenylyltransferase (Tokushima University Institutional Repository) ● Metadata: 119529 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijms25126384 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38928090 ● Search Scopus @ Elsevier (PMID): 38928090 ● Search Scopus @ Elsevier (DOI): 10.3390/ijms25126384 (Tokushima University Institutional Repository: 119529, DOI: 10.3390/ijms25126384, PubMed: 38928090)
3.	Kazuhiro Hasegawa, Masanori Tamaki, Eriko Shibata, Taizo Inagaki, Masanori Minato, Sumiyo Yamaguchi, Ikuko Shimizu, Shinji Miyakami, Miho Tada and Shu Wakino : Ability of NAD and Sirt1 to epigenetically suppress albuminuria., Clinical and Experimental Nephrology, Vol.28, No.7, 599-607, 2024. (Summary) The time for diabetic nephropathy (DN) to progress from mild to severe is long. Thus, methods to continuously repress DN are required to exert long-lasting effects mediated through epigenetic regulation. In this study, we demonstrated the ability of nicotinamide adenine dinucleotide (NAD) and its metabolites to reduce albuminuria through Sirt1- or Nampt-dependent epigenetic regulation. We previously reported that proximal tubular Sirt1 was lowered before glomerular Sirt1. Repressed glomerular Sirt1 was found to epigenetically elevate Claudin-1. In addition, we reported that proximal tubular Nampt deficiency epigenetically augmented TIMP-1 levels in Sirt6-mediated pathways, leading to type-IV collagen deposition and diabetic fibrosis. Altogether, we propose that the Sirt1/Claudin-1 axis may be crucial in the onset of albuminuria at the early stages of DN and that the Nampt/Sirt6/TIMP-1 axis promotes diabetic fibrosis in the middle to late stages of DN. Finally, administration of NMN, an NAD precursor, epigenetically potentiates the regression of the onset of DN to maintain Sirt1 and repress Claudin-1 in podocytes, suggesting the potential use of NAD metabolites as epigenetic medications for DN. (Keyword) Animals / Humans / Albuminuria / Claudin-1 / Cytokines / Diabetic Nephropathies / Epigenesis, Genetic / Fibrosis / Kidney Tubules, Proximal / Mice, Inbred C57BL / Mice, Knockout / NAD / Nicotinamide Mononucleotide / Nicotinamide Phosphoribosyltransferase / Podocytes / Sirtuin 1 / Sirtuins / Tissue Inhibitor of Metalloproteinase-1 (Tokushima University Institutional Repository) ● Metadata: 119528 (Link to Publication Site) ● Publication site (DOI): 10.1007/s10157-024-02502-w (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38587753 ● Search Scopus @ Elsevier (PMID): 38587753 ● Search Scopus @ Elsevier (DOI): 10.1007/s10157-024-02502-w (Tokushima University Institutional Repository: 119528, DOI: 10.1007/s10157-024-02502-w, PubMed: 38587753)
4.	Keika Adachi, Marie Yasuda, Makiko Ida, Takeshi Kanda, Akemi Morita, Shu Wakino, Shaw Watanabe and Hiroshi Itoh : Impact of dietary habits on renal function in Saku, a rural Japanese town: a cohort study., Clinical and Experimental Nephrology, Vol.28, No.8, 751-763, 2024. (Summary) High protein intake leads to a decline in renal function in the advanced stages of chronic kidney disease (CKD). An effective diet for maintaining renal function in healthy individuals or patients in the early stages of CKD has not been established. This cohort study was conducted in Saku, Nagano Prefecture, Japan, to investigate the impact of dietary habits on renal function. In this cross-sectional cohort study, we used the Saku Control Obesity Program (UMIN000016892), including 4,446 participants who submitted a brief-type self-administered diet history questionnaire and underwent routine physical examination. The amount of food intake was divided into quartiles. After adjusting for age and sex, multivariate logistic regression analysis was used to calculate the odds ratio (OR) for the risk of developing CKD (estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m). In total, 3,899 participants were analyzed. The overall prevalence of patients with eGFR < 60 mL/min/1.73 m was 11% (n = 434, male; 7.1%, female; 4.1%). The groups with a high intake of chicken (approximately 63.4 g/day, adjusted OR: 0.632, P = 0.003), natto (fermented bean; approximately 21.7 g/day, adjusted OR: 0.679, P = 0.01), and plant protein (approximately 0.8 g/ideal body weight/day, adjusted OR: 0.695, P = 0.042) showed a low risk of developing CKD compared to the group with the lowest intake. Our cross-sectional study showed that the intake of chicken meat, natto, and plant protein was associated with high eGFR levels. This information can be of value for preventing CKD incidence in healthy Japanese individuals. (Keyword) Adult / Aged / Female / Humans / Male / Middle Aged / Cross-Sectional Studies / East Asian People / Glomerular Filtration Rate / Japan / Kidney / Prevalence / Renal Insufficiency, Chronic / Risk Factors / Diet (Link to Publication Site) ● Publication site (DOI): 10.1007/s10157-024-02479-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38467892 ● Search Scopus @ Elsevier (PMID): 38467892 ● Search Scopus @ Elsevier (DOI): 10.1007/s10157-024-02479-6 (DOI: 10.1007/s10157-024-02479-6, PubMed: 38467892)
5.	Yasushi Furukawa, Keiko Tanaka, Osamu Isozaki, Atsushi Suzuki, Tadao Iburi, Kumiko Tsuboi, Moritake Iguchi, Naotetsu Kanamoto, Kanshi Minamitani, Shu Wakino, Tetsurou Satoh, Satoshi Teramukai, Eizen Kimura, Yoshihiro Miyake and Takashi Akamizu : Prospective Multicenter Registry-Based Study on Thyroid Storm: The Guidelines for the Management from Japan are Useful., The Journal of Clinical Endocrinology and Metabolism, 2024. (Summary) The mortality rate in thyroid storm (TS) has been reported to be higher than 10%. We aimed to evaluate the effectiveness of the 2016 guidelines for the management of TS proposed by the Japan Thyroid Association and Japan Endocrine Society. Prospective registry-based study through a secure web platform. Prospective multicenter registry. Patients with new-onset TS were registered in the Research Electronic Data Capture (REDCap). On day 30 after admission, clinical information and prognosis of each patient were added to the platform. On day 180, the prognosis was described. This study included 110 patients with TS. The median of Acute Physiology and Chronic Health Evaluation (APACHE) II score was 13, higher than the score in the previous nationwide epidemiological study, 10 (p = 0.001). Nonetheless, the mortality rate at day 30 was 5.5%, approximately half compared with 10.7% in the previous nationwide survey. Lower body mass index, shock and lower left ventricular ejection fraction were positively associated with poor prognosis at day 30, while the lack of fever ≥ 38℃ was related to the outcome. The mortality rate in patients with an APACHE II score ≥12 for whom the guidelines were not followed was significantly higher than the rate in patients for whom the guidelines were followed (50% vs. 4.7%) (p = 0.01). Prognosis seemed better than in the previous nationwide survey, even though disease severity was higher. The mortality rate was lower when the guidelines were followed. Thus, the guidelines are useful for managing TS. (Tokushima University Institutional Repository) ● Metadata: 119548 (Link to Publication Site) ● Publication site (DOI): 10.1210/clinem/dgae124 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38454797 ● Search Scopus @ Elsevier (PMID): 38454797 ● Search Scopus @ Elsevier (DOI): 10.1210/clinem/dgae124 (Tokushima University Institutional Repository: 119548, DOI: 10.1210/clinem/dgae124, PubMed: 38454797)
6.	Shimon Kurasawa, Sawako Kato, Takaya Ozeki, Shin'ichi Akiyama, Takuji Ishimoto, Masashi Mizuno, Naotake Tsuboi, Noritoshi Kato, Shu Wakino and Shoichi Maruyama : Rationale and design of the Japanese Biomarkers in Nephrotic Syndrome (J-MARINE) study., Clinical and Experimental Nephrology, Vol.28, No.5, 431-439, 2024. (Summary) This study will provide valuable insights into biomarkers for NS and serve as a biorepository for future studies. (Keyword) Humans / Biomarkers / Nephrotic Syndrome / Prospective Studies / Japan / Glomerulosclerosis, Focal Segmental / Receptors, Urokinase Plasminogen Activator / Glomerulonephritis, Membranous / Adult / Nephrosis, Lipoid / Research Design / Receptors, Phospholipase A2 / Thrombospondins / Glomerulonephritis, Membranoproliferative / Male / Female / Lupus Nephritis / East Asian People / B7-1 Antigen (Link to Publication Site) ● Publication site (DOI): 10.1007/s10157-023-02449-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38267800 ● Search Scopus @ Elsevier (PMID): 38267800 ● Search Scopus @ Elsevier (DOI): 10.1007/s10157-023-02449-4 (DOI: 10.1007/s10157-023-02449-4, PubMed: 38267800)
7.	Norito Yoshimura, Katsutoshi Yamada, Takashi Ono, Mitsuru Notoya, Hideo Yukioka, Rina Takahashi, Shu Wakino, Takeshi Kanda and Hiroshi Itoh : N-methyl-2-pyridone-5-carboxamide (N-Me-2PY) has potent anti-fibrotic and anti-inflammatory activity in a fibrotic kidney model: is it an old uremic toxin?, Clinical and Experimental Nephrology, 2023. (Summary) N-Me-2PY, N-Me-4PY, and nicotinamide N-oxide (NNO) inhibited TGFβ1-induced fibrosis and inflammatory gene expression in kidney fibroblasts. N-Me-2PY strongly suppressed the expression of types I and III collagen, αSMA, and IL-6. N-Me-2PY also suppressed TGFβ1-induced type I collagen and IL-6 expression in renal tubular epithelial cells. No toxic effect was observed with N-Me-2PY treatment, while attenuating renal fibrosis and tubular dilation in UUO mice. Suppression of various fibrosis- and inflammation-related genes was also observed. N-Me-2PY did not inhibit TGFβ1-induced Smad3 phosphorylation but inhibited Akt phosphorylation, suggesting that N-Me-2PY exerts anti-fibrotic and anti-inflammatory effects through Akt inhibition, similar to pirfenidone. (Link to Publication Site) ● Publication site (DOI): 10.1007/s10157-023-02379-1 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37490135 ● Search Scopus @ Elsevier (PMID): 37490135 ● Search Scopus @ Elsevier (DOI): 10.1007/s10157-023-02379-1 (DOI: 10.1007/s10157-023-02379-1, PubMed: 37490135)
8.	Kan Kikuchi, Masaomi Nangaku, Munekazu Ryuzaki, Tomoyuki Yamakawa, Yoshihiro Ota, Norio Hanafusa, Ken Sakai, Yoshihiko Kanno, Ryoichi Ando, Toshio Shinoda, Shu Wakino, Hidetomo Nakamoto, Yoshiaki Takemoto and Tadao Akizawa : Efficacy of molnupiravir and sotrovimab in Japanese dialysis patients with COVID-19 in clinical practice during the Omicron (BA.1 and BA.2) pandemic., Therapeutic Apheresis and Dialysis, 2023. (Summary) Sotrovimab showed efficacy in Omicron BA.1 but attenuated in BA.2. Molnupiravir also showed efficacy in BA.2, suggesting administration of molnupiravir would be important. (Link to Publication Site) ● Publication site (DOI): 10.1111/1744-9987.14033 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37395555 ● Search Scopus @ Elsevier (PMID): 37395555 ● Search Scopus @ Elsevier (DOI): 10.1111/1744-9987.14033 (DOI: 10.1111/1744-9987.14033, PubMed: 37395555)
9.	Kazuhiro Hasegawa, Yusuke Sakamaki, Masanori Tamaki and Shu Wakino : PCK1 Protects against Mitoribosomal Defects in Diabetic Nephropathy in Mouse Models., Journal of the American Society of Nephrology, Vol.34, No.8, 1343-1365, 2023. (Summary) PCK1 preserves mitoribosomal function and may play a novel protective role in DN. (Keyword) Mice / Animals / Diabetic Nephropathies / Diabetes Mellitus, Experimental / Collagen Type IV / Albuminuria / Diabetes Mellitus, Type 2 / Phosphoenolpyruvate / Phosphoenolpyruvate Carboxykinase (GTP) / Sodium-Glucose Transporter 2 Inhibitors / Disease Models, Animal / Mice, Transgenic / Fibrosis / Mice, Knockout / Glucose (Link to Publication Site) ● Publication site (DOI): 10.1681/ASN.0000000000000156 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37199399 ● Search Scopus @ Elsevier (PMID): 37199399 ● Search Scopus @ Elsevier (DOI): 10.1681/ASN.0000000000000156 (DOI: 10.1681/ASN.0000000000000156, PubMed: 37199399)
10.	Ayumi Yoshifuji, Masataro Toda, Munekazu Ryuzaki, Emi Oyama, Kan Kikuchi, Toru Kawai, Ken Sakai, Masayoshi Koinuma, Kazuhiko Katayama, Takashi Yokoyama, Yuki Uehara, Norio Ohmagari, Yoshihiko Kanno, Hirofumi Kon, Toshio Shinoda, Yaoko Takano, Junko Tanaka, Kazuhiko Hora, Yasushi Nakazawa, Naoki Hasegawa, Norio Hanafusa, Fumihiko Hinoshita, Keita Morikane, Shu Wakino, Hidetomo Nakamoto and Yoshiaki Takemoto : T-Cell Response and Antibody Production Induced by the COVID-19 Booster Vaccine in Japanese Chronic Kidney Disease Patients Treated with Hemodialysis., Vaccines, Vol.11, No.3, 2023. (Summary) COVID test (T-SPOT) were measured prior to, three weeks after, and three months after the booster administration. The HD group had significantly higher SARS-CoV-2 IgG levels and neutralizing antibody titers against the original strain at three weeks and three months after the booster vaccination compared to the control group, albeit the HD group had lower SARS-CoV-2 IgG levels and neutralizing antibody titers before the booster administration. Moreover, the HD group had significantly higher T-SPOT levels at all three time points compared to the control group. The HD group also had significantly higher local and systemic adverse reaction rates than the control group. By booster vaccination, HD patients could acquire more effective SARS-CoV-2-specific humoral and cellular immunity than the control group. (Tokushima University Institutional Repository) ● Metadata: 118478 (Link to Publication Site) ● Publication site (DOI): 10.3390/vaccines11030653 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36992238 ● Search Scopus @ Elsevier (PMID): 36992238 ● Search Scopus @ Elsevier (DOI): 10.3390/vaccines11030653 (Tokushima University Institutional Repository: 118478, DOI: 10.3390/vaccines11030653, PubMed: 36992238)
11.	Yoichi Oshima, Shu Wakino, Takeshi Kanda, Takaya Tajima, Tomoaki Itoh, Kiyotaka Uchiyama, Keiko Yoshimoto, Jumpei Sasabe, Masato Yasui and Hiroshi Itoh : Sodium benzoate attenuates 2,8-dihydroxyadenine nephropathy by inhibiting monocyte/macrophage TNF-α expression., Scientific Reports, Vol.13, No.1, 2023. (Summary) Sodium benzoate (SB), a known D-amino acid oxidase (DAO) enzyme inhibitor, has an anti-inflammatory effect, although its role in renal damage has not been explored. 2,8-dihydroxyadenine crystal induced chronic kidney disease, in which TNF-α is involved in the pathogenesis, was established by oral adenine administration in C57BL/6JJcl mice (AdCKD) with or without SB to investigate its renal protective effects. SB significantly attenuated AdCKD by decreasing serum creatinine and urea nitrogen levels, and kidney interstitial fibrosis and tubular atrophy scores. The survival of AdCKD mice improved 2.6-fold by SB administration. SB significantly decreased the number of infiltrating macrophages observed in the positive F4/80 immunohistochemistry area and reduced the expression of macrophage markers and inflammatory genes, including TNF-α, in the kidneys of AdCKD. Human THP-1 cells stimulated with either lipopolysaccharide or TNF-α showed increased expression of inflammatory genes, although this was significantly reduced by SB, confirming the anti-inflammatory effects of SB. SB exhibited renal protective effects in AdCKD in DAO enzyme deficient mice, suggesting that anti-inflammatory effect of SB was independent of DAO enzyme activity. Moreover, binding to motif DNA sequence, protein level, and mRNA level of NF-κB RelB were significantly inhibited by SB in AdCKD kidneys and lipopolysaccharide treated THP-1 cells, respectively. We report that anti-inflammatory property of SB is independent of DAO enzymatic activity and is associated with down regulated NF-κB RelB as well as its downstream inflammatory genes such as TNF-α in AdCKD. (Keyword) Humans / Animals / Mice / Mice, Inbred C57BL / Tumor Necrosis Factor-alpha / Sodium Benzoate / Lipopolysaccharides / Monocytes / NF-kappa B / Macrophages / Renal Insufficiency, Chronic (Tokushima University Institutional Repository) ● Metadata: 118479 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-023-30056-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36849798 ● Search Scopus @ Elsevier (PMID): 36849798 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-30056-6 (Tokushima University Institutional Repository: 118479, DOI: 10.1038/s41598-023-30056-6, PubMed: 36849798)
12.	Ayumi Matsui, Ayumi Yoshifuji, Junichiro Irie, Takaya Tajima, Kiyotaka Uchiyama, Tomoaki Itoh, Shu Wakino and Hiroshi Itoh : Canagliflozin protects the cardiovascular system through effects on the gut environment in non-diabetic nephrectomized rats., Clinical and Experimental Nephrology, Vol.27, No.4, 295-308, 2023. (Summary) The increases in colonic glucose concentration, Lactobacillus numbers and tight junction protein expression, and the decreases in serum uremic toxin concentrations and cardiac interstitial fibrosis may have been caused by the inhibition of SGLT1 by canagliflozin because similar effects were not identified in tofogliflozin-treated rats. (Keyword) Rats / Animals / Canagliflozin / Sodium-Glucose Transporter 2 Inhibitors / Cardiovascular System / Glucose / Fibrosis (Link to Publication Site) ● Publication site (DOI): 10.1007/s10157-022-02312-y (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36611128 ● Search Scopus @ Elsevier (PMID): 36611128 ● Search Scopus @ Elsevier (DOI): 10.1007/s10157-022-02312-y (DOI: 10.1007/s10157-022-02312-y, PubMed: 36611128)
13.	Kunihisa Yamaguchi, Keisuke Ozaki, Tomoya Fukawa, Yutaro Sasaki, Shu Wakino and Masayuki Takahashi : Drug-induced de novo thrombotic microangiopathy diagnosed 2 years after renal transplantation: A case report and literature review, Renal Replacement Therapy, Vol.9, 1-6, 2023. (Tokushima University Institutional Repository) ● Metadata: 119041 (Link to Publication Site) ● Publication site (DOI): 10.1186/s41100-022-00453-0 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1186/s41100-022-00453-0 (Tokushima University Institutional Repository: 119041, DOI: 10.1186/s41100-022-00453-0)
14.	Shu Wakino : 8．栄養, J. Jpn. Soc. Dial. Ther., Vol.56, No.12, 565-568, 2023. (Tokushima University Institutional Repository) ● Metadata: 119549 (Link to Publication Site) ● Publication site (DOI): 10.4009/jsdt.56.565 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390861559985635456 ● Search Scopus @ Elsevier (DOI): 10.4009/jsdt.56.565 (Tokushima University Institutional Repository: 119549, DOI: 10.4009/jsdt.56.565, CiNii: 1390861559985635456)
15.	Ayumi Yoshifuji, Masataro Toda, Munekazu Ryuzaki, Kan Kikuchi, Toru Kawai, Ken Sakai, Emi Oyama, Masayoshi Koinuma, Kazuhiko Katayama, Yuki Uehara, Norio Ohmagari, Yoshihiko Kanno, Hirofumi Kon, Toshio Shinoda, Yaoko Takano, Junko Tanaka, Kazuhiko Hora, Yasushi Nakazawa, Naoki Hasegawa, Norio Hanafusa, Fumihiko Hinoshita, Keita Morikane, Shu Wakino, Hidetomo Nakamoto and Yoshiaki Takemoto : Investigation for the efficacy of COVID-19 vaccine in Japanese CKD patients treated with hemodialysis., Renal Replacement Therapy, Vol.8, No.1, 2022. (Summary) Dialysis patients are predisposed to severe disease and have a high mortality rate in coronavirus disease 2019 (COVID-19) due to their comorbidities and immunocompromised conditions. Therefore, dialysis patients should be prioritized for vaccination. This study aimed to examine how long the effects of the vaccine are maintained and what factors affect antibody titers. (Tokushima University Institutional Repository) ● Metadata: 118481 (Link to Publication Site) ● Publication site (DOI): 10.1186/s41100-022-00427-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35999867 ● Search Scopus @ Elsevier (PMID): 35999867 ● Search Scopus @ Elsevier (DOI): 10.1186/s41100-022-00427-2 (Tokushima University Institutional Repository: 118481, DOI: 10.1186/s41100-022-00427-2, PubMed: 35999867)
16.	Makiko Ida-Naitoh, Hirobumi Tokuyama, Koji Futatsugi, Marie Yasuda, Keika Adachi, Takeshi Kanda, Yoshiyuki Tanabe, Shu Wakino and Hiroshi Itoh : Proximal-tubule molecular relay from early Protein diaphanous homolog 1 to late Rho-associated protein kinase 1 regulates kidney function in obesity-induced kidney damage., Kidney International, Vol.102, No.4, 798-814, 2022. (Summary) The small GTPase protein RhoA has two effectors, ROCK (Rho-associated protein kinase 1) and mDIA1 (protein diaphanous homolog 1), which cooperate reciprocally. However, temporal regulation of RhoA and its effectors in obesity-induced kidney damage remains unclear. Here, we investigated the role of RhoA activation in the proximal tubules at the early and late stages of obesity-induced kidney damage. In mice, a three-week high-fat-diet induced proximal tubule hypertrophy and damage without increased albuminuria, and RhoA/mDIA1 activation without ROCK activation. Conversely, a 12-week high-fat diet induced proximal tubule hypertrophy, proximal tubule damage, increased albuminuria, and RhoA/ROCK activation without mDIA1 elevation. Proximal tubule hypertrophy resulting from cell cycle arrest accompanied by downregulation of the multifunctional cyclin-dependent kinase inhibitor p27Kip1 was elicited by RhoA activation. Mice overexpressing proximal tubule-specific and dominant-negative RHOA display amelioration of high-fat diet-induced kidney hypertrophy, cell cycle abnormalities, inflammation, and renal impairment. In human proximal tubule cells, mechanical stretch mimicking hypertrophy activated ROCK, which triggered inflammation. In human kidney samples from normal individuals with a body mass index of about 25, proximal tubule cell size correlated with body mass index, proximal tubule cell damages, and mDIA1 expression. Thus, RhoA activation in proximal tubules is critical for the initiation and progression of obesity-induced kidney damage. Hence, the switch in the downstream RhoA effector in proximal tubule represents a transition from normal to pathogenic kidney adaptation and to body weight gain, leading to obesity-induced kidney damage. (Keyword) Albuminuria / Animals / Cyclin-Dependent Kinases / Humans / Hypertrophy / Inflammation / Kidney Tubules, Proximal / Mice / Obesity / rho-Associated Kinases (Link to Publication Site) ● Publication site (DOI): 10.1016/j.kint.2022.05.018 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35716954 ● Search Scopus @ Elsevier (PMID): 35716954 ● Search Scopus @ Elsevier (DOI): 10.1016/j.kint.2022.05.018 (DOI: 10.1016/j.kint.2022.05.018, PubMed: 35716954)
17.	Kan Kikuchi, Masaomi Nangaku, Munekazu Ryuzaki, Tomoyuki Yamakawa, Ota Yoshihiro, Norio Hanafusa, Ken Sakai, Yoshihiko Kanno, Ryoichi Ando, Toshio Shinoda, Shu Wakino, Hidetomo Nakamoto, Yoshiaki Takemoto and Tadao Akizawa : Effectiveness of SARS-CoV-2 vaccines on hemodialysis patients in Japan: A nationwide cohort study., Therapeutic Apheresis and Dialysis, Vol.27, No.1, 19-23, 2022. (Summary) Our prospective observational study showed that SRAS-CoV-2 vaccination in hemodialysis patients is vital for reducing need of oxygen supplementation and mortality risk. (Keyword) Humans / COVID-19 Vaccines / Cohort Studies / COVID-19 / Japan / SARS-CoV-2 / Oxygen / Renal Dialysis / Vaccination (Link to Publication Site) ● Publication site (DOI): 10.1111/1744-9987.13887 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35610734 ● Search Scopus @ Elsevier (PMID): 35610734 ● Search Scopus @ Elsevier (DOI): 10.1111/1744-9987.13887 (DOI: 10.1111/1744-9987.13887, PubMed: 35610734)
18.	Erina Sugita, Homare Sonoda, Masaki Ryuzaki, Akinori Hashiguchi, Hirobumi Tokuyama, Shu Wakino, Takeshi Kanda and Hiroshi Itoh : Diagnosis of monoclonal immunotactoid glomerulopathy with positive λ chain by immunoelectron microscopy., CEN Case Reports, Vol.12, No.1, 7-13, 2022. (Summary) We report the case of a 73-year-old-man who developed immunotactoid glomerulopathy (ITG). ITG is a rare disease characterized by proliferative glomerulonephritis and capillary wall deposits with a 10-60 nm diameter microtubular substructure. In monoclonal ITG, immunofluorescence analysis typically exhibits IgG with light chain restriction. Recent reviews recommend distinguishing monoclonal ITG from polyclonal ITG because monoclonal ITG is associated with a higher incidence of hematological disorders and better responsiveness to clone-directed therapy and renal prognosis. In our case, IgG, IgA, and IgM were negative by routine immunofluorescence; however, immunoelectron microscopy revealed positive λ chain. At 6 months after renal biopsy, the IgG λ chain was detected in the serum and urine, reflecting possible monoclonality. Therefore, it is useful to perform immunoelectron microscopy and follow-up with serum and urine protein electrophoresis and immunofixation to diagnose monoclonal ITG, even when routine immunofluorescence shows negative or nonspecific findings. (Keyword) Humans / Aged / Microscopy, Immunoelectron / Glomerulonephritis / Kidney / Prognosis / Immunoglobulin G (Link to Publication Site) ● Publication site (DOI): 10.1007/s13730-022-00714-1 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35699924 ● Search Scopus @ Elsevier (PMID): 35699924 ● Search Scopus @ Elsevier (DOI): 10.1007/s13730-022-00714-1 (DOI: 10.1007/s13730-022-00714-1, PubMed: 35699924)
19.	Ayumi Yoshifuji, Munekazu Ryuzaki, Yuki Uehara, Norio Ohmagari, Toru Kawai, Yoshihiko Kanno, Kan Kikuchi, Hiroshi Kon, Ken Sakai, Toshio Shinoda, Yaoko Takano, Junko Tanaka, Kazuhiko Hora, Yasushi Nakazawa, Naoki Hasegawa, Norio Hanafusa, Fumihiko Hinoshita, Keita Morikane, Shu Wakino, Hidetomo Nakamoto and Yoshiaki Takemoto : Committee report: Questionnaire survey on the treatment of COVID-19 in patients receiving dialysis therapy., Renal Replacement Therapy, Vol.8, No.1, 2022. (Summary) Our survey revealed a variety of treatment practices in each facility. Further evidence and innovations are required to improve the prognosis of patients with COVID-19 receiving dialysis therapy. (Tokushima University Institutional Repository) ● Metadata: 118486 (Link to Publication Site) ● Publication site (DOI): 10.1186/s41100-022-00405-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35494536 ● Search Scopus @ Elsevier (PMID): 35494536 ● Search Scopus @ Elsevier (DOI): 10.1186/s41100-022-00405-8 (Tokushima University Institutional Repository: 118486, DOI: 10.1186/s41100-022-00405-8, PubMed: 35494536)
20.	Kiyotaka Uchiyama, Kohkichi Morimoto, Naoki Washida, Ei Kusahana, Takashin Nakayama, Tomoaki Itoh, Takahiro Kasai, Shu Wakino and Hiroshi Itoh : Effects of a remote patient monitoring system for patients on automated peritoneal dialysis: a randomized crossover controlled trial., International Urology and Nephrology, Vol.54, No.10, 2673-2681, 2022. (Summary) The study was registered in the Japan Registry of Clinical Trials (jRCT Number: jRCTs032190005). (Keyword) Aged / Humans / Kidney Failure, Chronic / Male / Monitoring, Physiologic / Patient Satisfaction / Peritoneal Dialysis / Prospective Studies / Quality of Life (Link to Publication Site) ● Publication site (DOI): 10.1007/s11255-022-03178-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35362819 ● Search Scopus @ Elsevier (PMID): 35362819 ● Search Scopus @ Elsevier (DOI): 10.1007/s11255-022-03178-5 (DOI: 10.1007/s11255-022-03178-5, PubMed: 35362819)
21.	Keika Adachi, Kiyotaka Uchiyama, Kaori Muraoka, Takashin Nakayama, Marie Yasuda, Kazutoshi Miyashita, Hirobumi Tokuyama, Shu Wakino and Hiroshi Itoh : Home-Based Exercise Program Ameliorates Renal Function Decline in Patients With CKD Stage 4., Kidney International Reports, Vol.7, No.4, 899-903, 2022. (Tokushima University Institutional Repository) ● Metadata: 118485 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ekir.2022.01.006 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35497789 ● CiNii @ National Institute of Informatics (CRID): 1050578979247097344 ● Summary page in Scopus @ Elsevier: 2-s2.0-85123373964 (Tokushima University Institutional Repository: 118485, DOI: 10.1016/j.ekir.2022.01.006, PubMed: 35497789, CiNii: 1050578979247097344, Elsevier: Scopus)
22.	Kiyotaka Uchiyama, Keika Adachi, Kaori Muraoka, Takashin Nakayama, Takuma Oshida, Marie Yasuda, Akihito Hishikawa, Hitoshi Minakuchi, Kazutoshi Miyashita, Hirobumi Tokuyama, Shu Wakino and Hiroshi Itoh : Home-based aerobic exercise and resistance training for severe chronic kidney disease: a randomized controlled trial., Journal of Cachexia, Sarcopenia and Muscle, Vol.12, No.6, 1789-1802, 2021. (Summary) Our 6 month home-based exercise programme improved aerobic capacity and HRQOL in patients with Stage 4 CKD, with possible beneficial effects on kidney function and CKD-related parameters. (Keyword) Aged / Exercise / Exercise Therapy / Humans / Male / Quality of Life / Renal Insufficiency, Chronic / Resistance Training (Tokushima University Institutional Repository) ● Metadata: 118488 (Link to Publication Site) ● Publication site (DOI): 10.1002/jcsm.12775 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34554649 ● Search Scopus @ Elsevier (PMID): 34554649 ● Search Scopus @ Elsevier (DOI): 10.1002/jcsm.12775 (Tokushima University Institutional Repository: 118488, DOI: 10.1002/jcsm.12775, PubMed: 34554649)
23.	Keika Adachi, Hirobumi Tokuyama, Yoichi Oshima, Tomoaki Itoh, Akinori Hashiguchi, Hiroyuki Yamakawa, Tadayasu Togawa, Hitoshi Sakuraba, Shu Wakino and Hiroshi Itoh : Fabry disease associated with multiple myeloma: a case report., CEN Case Reports, Vol.11, No.1, 146-153, 2021. (Summary) Fabry disease (FD) is an X-linked genetic lysosomal disorder caused by alpha-galactosidase A (GLA) deficiency. Multiple myeloma (MM) predominately affects older adults, which ranks as the second commonest hematological malignancy. Their overlap has rarely been reported. We present a case of the coexistence of FD and MM in a patient. We report the case of a 68-year-old woman who was referred to our hospital for the evaluation of thoracic spine tumor with bone destruction. On admission, her serum creatinine (Cr) level was elevated to 12.70 mg/dL from the baseline value of 0.91 mg/dL. Bone marrow aspiration revealed MM. Renal biopsy showed myeloma cast nephropathy, which was the primary cause of acute kidney injury. Renal pathology also showed podocyte swelling and tubule myeloid bodies in a mosaic pattern compatible with female FD. Consequently, the patient was diagnosed as FD based on the germ line mutation in GLA. The patient was treated with bortezomib and dexamethasone therapy, which significantly improved the renal function. This is the second case demonstrating a potential pathogenic relationship between FD and MM. Since FD is one of the few genetic diseases for which there are therapeutic agents with fewer side effects, diagnostic value of FD is high. If an MM patient has multiple organ abnormalities or any familial history, the physician should suspect FD. (Keyword) Aged / Bortezomib / Fabry Disease / Female / Humans / Kidney / Kidney Diseases / Male / Multiple Myeloma (Link to Publication Site) ● Publication site (DOI): 10.1007/s13730-021-00613-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34529243 ● Search Scopus @ Elsevier (PMID): 34529243 ● Search Scopus @ Elsevier (DOI): 10.1007/s13730-021-00613-x (DOI: 10.1007/s13730-021-00613-x, PubMed: 34529243)
24.	Takashin Nakayama, Kiyotaka Uchiyama, Kohkichi Morimoto, Naoki Washida, Takahiro Kasai, Ran Nakamichi, Ei Kusahana, Shu Wakino and Hiroshi Itoh : Efficacy of dexmedetomidine on peritoneal dialysis catheter insertion., International Urology and Nephrology, Vol.54, No.1, 209-215, 2021. (Summary) The use of DEX in PD catheter insertion under spinal anesthesia could safely improve operative analgesia. (Keyword) Aged / Anesthesia, Spinal / Catheterization / Dexmedetomidine / Female / Humans / Hypnotics and Sedatives / Male / Middle Aged / Pain, Procedural / Peritoneal Dialysis / Retrospective Studies / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1007/s11255-021-02916-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34143371 ● Search Scopus @ Elsevier (PMID): 34143371 ● Search Scopus @ Elsevier (DOI): 10.1007/s11255-021-02916-5 (DOI: 10.1007/s11255-021-02916-5, PubMed: 34143371)
25.	Itaru Yasuda, Kazuhiro Hasegawa, Yusuke Sakamaki, Hirokazu Muraoka, Takahisa Kawaguchi, Ei Kusahana, Takashi Ono, Takeshi Kanda, Hirobumi Tokuyama, Shu Wakino and Hiroshi Itoh : Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy., Journal of the American Society of Nephrology, Vol.32, No.6, 1355-1370, 2021. (Summary) salvage pathway, both of which indicate NMN legacy effects on DN. (Keyword) Albuminuria / Animals / Claudin-1 / Cytokines / DNA (Cytosine-5-)-Methyltransferase 1 / Diabetic Nephropathies / Disease Models, Animal / Dose-Response Relationship, Drug / Epigenesis, Genetic / Glomerular Mesangium / Glycated Hemoglobin / Histones / Male / Mice / Mice, Knockout / NAD / Nicotinamide Mononucleotide / Nicotinamide Phosphoribosyltransferase / Nicotinamide-Nucleotide Adenylyltransferase / Podocytes / Sirtuin 1 / Survival Rate / Time Factors (Link to Publication Site) ● Publication site (DOI): 10.1681/ASN.2020081188 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33795425 ● Search Scopus @ Elsevier (PMID): 33795425 ● Search Scopus @ Elsevier (DOI): 10.1681/ASN.2020081188 (DOI: 10.1681/ASN.2020081188, PubMed: 33795425)
26.	Kaori Hayashi, Akinori Hashiguchi, Masako Ikemiyagi, Hirobumi Tokuyama, Shu Wakino and Hiroshi Itoh : Development of nephropathy in an adult patient after Fontan palliation for cyanotic congenital heart disease., CEN Case Reports, Vol.10, No.3, 354-358, 2021. (Summary) Cyanotic congenital heart disease is occasionally associated with kidney dysfunction, which is known as cyanotic nephropathy or cyanotic glomerulopathy. The clinical presentation of cyanotic nephropathy includes proteinuria, decreased estimated glomerular filtration rate, hyperuricemia, thrombocytopenia, or polycythemia. Although advances in surgical procedures have improved the prognosis of cyanotic congenital heart diseases, adult cases of cyanotic nephropathy are still rare, and there are few reports of kidney biopsy in adults with cyanotic nephropathy. Here, we present the case of a 41-year-old patient with Fontan palliation who developed nephrotic range proteinuria and had a kidney biopsy, which showed glomerular hypertrophy with segmental glomerulosclerosis around vascular poles, suggesting adaptive focal segmental glomerulosclerosis. This case provides further understanding of kidney dysfunction due to cyanotic congenital heart disease and shows the need for attention in the management for prevention of progression to end-stage renal disease and in the selection of renal replacement therapy. (Keyword) Adult / Fontan Procedure / Heart Defects, Congenital / Humans / Kidney Diseases (Link to Publication Site) ● Publication site (DOI): 10.1007/s13730-021-00573-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33476039 ● Search Scopus @ Elsevier (PMID): 33476039 ● Search Scopus @ Elsevier (DOI): 10.1007/s13730-021-00573-2 (DOI: 10.1007/s13730-021-00573-2, PubMed: 33476039)
27.	Takahisa Kawaguchi, Kazuhiro Hasegawa, Itaru Yasuda, Hirokazu Muraoka, Hiroyuki Umino, Hirobumi Tokuyama, Akinori Hashiguchi, Shu Wakino and Hiroshi Itoh : Diabetic condition induces hypertrophy and vacuolization in glomerular parietal epithelial cells., Scientific Reports, Vol.11, No.1, 2021. (Summary) Diabetic nephropathy (DN) is accompanied by characteristic changes in the glomerulus, but little is known about the effect of diabetes on parietal epithelial cells (PECs). In this study, a descriptive analysis of PECs was undertaken in diabetic db/db mice and in diabetic patients. PEC hypertrophy was significantly more prominent in diabetic mice than in nondiabetic mice, and this was evident even at the early stage. Additionally, the number of vacuoles in PECs was markedly increased in diabetic mice, suggesting the presence of cellular injury in PECs in DN. Although rare, binuclear cells were observed in mice with early diabetes. In cultured PECs, a high glucose condition, compared with normal glucose condition, induced cellular hypertrophy and apoptosis. Flow cytometry showed that some PECs in the G0 phase reentered the cell cycle but got arrested in the S phase. Finally, in human diabetic subjects, hypertrophy and vacuolization were observed in the PECs. Our data showed that PECs undergo substantial changes in DN and may participate in rearrangement for differentiation into podocytes. (Keyword) Adult / Aged / Animals / Bowman Capsule / Cell Differentiation / Cells, Cultured / Diabetes Mellitus / Diabetes Mellitus, Experimental / Diabetic Nephropathies / Disease Models, Animal / Epithelial Cells / Female / Humans / Hypertrophy / Kidney Glomerulus / Male / Mice / Mice, Obese / Middle Aged / Podocytes (Tokushima University Institutional Repository) ● Metadata: 118492 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-021-81027-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33452384 ● Search Scopus @ Elsevier (PMID): 33452384 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-021-81027-8 (Tokushima University Institutional Repository: 118492, DOI: 10.1038/s41598-021-81027-8, PubMed: 33452384)
28.	Itaru Yasuda, Hirobumi Tokuyama, Akinori Hashiguchi, Kazuhiro Hasegawa, Kiyotaka Uchiyama, Masaki Ryuzaki, Marie Yasuda, Ryuichi Mizuno, Shigeto Ishidoya, Shu Wakino and Hiroshi Itoh : Malignancy-associated membranous nephropathy with PLA2R double-positive for glomeruli and carcinoma., CEN Case Reports, Vol.10, No.2, 281-286, 2021. (Summary) Phospholipase A2 receptor (PLA2R) is the most common primary target antigen of idiopathic membranous nephropathy (MN) although PLA2R antibodies are also reported to be present in malignancy-associated MN. However, a case of PLA2R-positive MN secondary to PLA2R-positive carcinoma has not been reported. A 26-year-old Japanese woman presented with general fatigue, fever, and nonproductive cough. Computed tomography demonstrated a left kidney mass with pathologic diagnosis of Xp11.2 translocation renal cell carcinoma (RCC). After the second time of administration with Sunitinib, the patients exhibited significant proteinuria and hypoalbuminemia. Renal biopsy revealed a diagnosis of diffuse MN secondary to RCC. Immunofluorescence staining showed granular patterns positive for immunoglobulin (Ig) G, IgA, and C3c. PLA2R and IgG1-3 were positive, while IgG4 was negative. For the treatment of severe nephrotic syndrome, we attempted steroid therapy without any clinical improvement. Open nephrectomy was performed and surprisingly, RCC was stained for PLA2R with polarity for the basal side. At outpatient follow-up, 4 months after the operation, urinary protein had still persisted, although serum albumin was slightly increased. We report a case of PLA2R-positive MN secondary to PLA2R-positive RCC. (Keyword) Adult / Carcinoma / Female / Glomerulonephritis, Membranous / Humans / Kidney Glomerulus / Receptors, Phospholipase A2 (Link to Publication Site) ● Publication site (DOI): 10.1007/s13730-020-00556-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33393071 ● Search Scopus @ Elsevier (PMID): 33393071 ● Search Scopus @ Elsevier (DOI): 10.1007/s13730-020-00556-9 (DOI: 10.1007/s13730-020-00556-9, PubMed: 33393071)
29.	Takashin Nakayama, Kiyotaka Uchiyama, Naoki Washida, Kohkichi Morimoto, Kaori Muraoka, Keika Adachi, Takahiro Kasai, Kazutoshi Miyashita, Shu Wakino and Hiroshi Itoh : Exercise Parameters Predict Technique Survival in Patients on Peritoneal Dialysis., Blood Purification, Vol.50, No.3, 380-389, 2020. (Summary) The ISWT is an important predictor of technique survival for patients on PD. Monitoring and enhancing ISWT as a marker of aerobic capacity might improve PD-related outcomes. (Keyword) Aged / Aged, 80 and over / Exercise / Exercise Tolerance / Female / Follow-Up Studies / Hand Strength / Humans / Male / Middle Aged / Peritoneal Dialysis / Peritonitis / Prognosis / Survival Analysis / Survival Rate (Tokushima University Institutional Repository) ● Metadata: 118494 (Link to Publication Site) ● Publication site (DOI): 10.1159/000511293 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33091919 ● Search Scopus @ Elsevier (PMID): 33091919 ● Search Scopus @ Elsevier (DOI): 10.1159/000511293 (Tokushima University Institutional Repository: 118494, DOI: 10.1159/000511293, PubMed: 33091919)
30.	Hitoshi Minakuchi, Shu Wakino, Hidenori Urai, Arata Kurokochi, Kazuhiro Hasegawa, Takeshi Kanda, Hirobumi Tokuyama and Hiroshi Itoh : The effect of aldosterone and aldosterone blockade on the progression of chronic kidney disease: a randomized placebo-controlled clinical trial., Scientific Reports, Vol.10, No.1, 2020. (Summary) /year, p = 0.0047). In the final intervention study, in the eplerenone group, eGFR dropped at 6 months after the initiation of the study, and thereafter eGFR was maintained until the end of the study. At 24 months and 36 months, eGFR was significantly higher in the eplerenone group than in the placebo group. In conclusion, MRA can be an effective strategy in preventing CKD progression, especially in patients with high plasma aldosterone. (Keyword) Adolescent / Adult / Aged / Aged, 80 and over / Aldosterone / Disease Progression / Eplerenone / Female / Glomerular Filtration Rate / Humans / Male / Middle Aged / Mineralocorticoid Receptor Antagonists / Prospective Studies / Renal Insufficiency, Chronic / Single-Blind Method / Treatment Outcome / Young Adult (Tokushima University Institutional Repository) ● Metadata: 118495 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-020-73638-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33024237 ● Search Scopus @ Elsevier (PMID): 33024237 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-020-73638-4 (Tokushima University Institutional Repository: 118495, DOI: 10.1038/s41598-020-73638-4, PubMed: 33024237)

Review, Commentary:

1.	Masanori Tamaki and Shu Wakino : 増大号 AKI·CKDの診断·治療に臨床検査を活かせ 4章腎疾患を知る-臨床検査ができること臨床検査で迫る腎疾患糖尿病性腎症·腎臓病と腎硬化症, Journal of Medical Technology, Vol.68, No.4, 524-527, Apr. 2024. (Link to Publication Site) ● Publication site (DOI): 10.11477/mf.1542203599 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390581003357831808 ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1542203599 (DOI: 10.11477/mf.1542203599, CiNii: 1390581003357831808)
2.	Shu Wakino, Masanori Tamaki and Eriko Shibata : 特集微量元素みいつけた : 生理作用・疾患・くすりと食品にクローズアップ! ; 場面別! 知っておきたい欠乏症とその予防・治療の方法, The Journal of Practical Pharmacy, Vol.75, No.3, 346-350, Mar. 2024. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520299596038519296 (CiNii: 1520299596038519296)
3.	Kazuhiro Hasegawa, Masanori Tamaki, Eriko Shibata, Masanori Minato, Taizo Inagaki, 清水郁子, 山口純代, 宮上慎司, 多田美穂 and Shu Wakino : 特集糖尿病性腎症研究の最前線糖尿病性腎症の発症機序糖尿病性腎症におけるミトコンドリアの役割, Kidney and Dialysis, Vol.96, No.2, 159-164, Feb. 2024. (Link to Publication Site) ● Publication site (DOI): 10.24479/kd.0000001187 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390299528381041664 ● Search Scopus @ Elsevier (DOI): 10.24479/kd.0000001187 (DOI: 10.24479/kd.0000001187, CiNii: 1390299528381041664)
4.	Shu Wakino, Kazuhiro Hasegawa, Masanori Tamaki and Eriko Shibata : 特集血液透析患者の血圧を再考する 5.透析患者の至適血圧-腹膜透析も含む, The Japanese Journal of Clinical Dialysis, Vol.40, No.2, 155-163, Feb. 2024. (Link to Publication Site) ● Publication site (DOI): 10.19020/cd.0000002887 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390862168254226944 ● Search Scopus @ Elsevier (DOI): 10.19020/cd.0000002887 (DOI: 10.19020/cd.0000002887, CiNii: 1390862168254226944)
5.	Shu Wakino : 特集病因·病態生理から読み解く腎·泌尿器疾患のすべて Ⅴ.AKI 5.心臓手術におけるAKI, 腎と透析, Vol.95, No.7, 361-366, Dec. 2023. (Link to Publication Site) ● Publication site (DOI): 10.24479/kd.0000001057 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390861859460431104 ● Search Scopus @ Elsevier (DOI): 10.24479/kd.0000001057 (DOI: 10.24479/kd.0000001057, CiNii: 1390861859460431104)
6.	Shu Wakino : 糖尿病性腎症から慢性腎臓病治療への新規治療戦略, Shikoku Acta Medica, Vol.79, No.1-2, 73-78, Jun. 2023. (Tokushima University Institutional Repository) ● Metadata: 118419 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050578747057266048 (Tokushima University Institutional Repository: 118419, CiNii: 1050578747057266048)
7.	Shu Wakino : 実地医家が知っておくべき臨床栄養学慢性腎臓病患者(透析患者も含む)への対応, 日本臨床内科医会会誌, Vol.38, No.1, 48-56, Jun. 2023.
8.	Shu Wakino : 【腸腎連関に関する最近の話題】メタボリックシンドロームと腸腎連関, Japanese Journal of Nephrology, Vol.65, No.2, 74-80, Mar. 2023. (Keyword) 脇野修
9.	Shu Wakino : 【高齢者の消化器疾患-最新の診断と治療-】消化器疾患-腎疾患相関への加齢への影響, Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.81, No.2, 305-314, Feb. 2023.
10.	Shu Wakino, Kazuhiro Hasegawa and Masanori Tamaki : 近位尿細管から見た糖尿病性腎臓病と肥満関連腎症, Cardioangiology, Vol.93, No.2, 182-189, Feb. 2023. (Keyword) proximal tabular cell / diabetic kidney disease / obesity / SGLT2 / Sirtuin (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520013962704009344 (CiNii: 1520013962704009344)
11.	Masanori Tamaki, Kazuhiro Hasegawa and Shu Wakino : 【急性腎障害(AKI)】AKIの病態とその対応手術とAKI, Kidney and Dialysis, Vol.94, No.1, 83-86, Jan. 2023. (Link to Publication Site) ● Publication site (DOI): 10.24479/kd.0000000586 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390016195131521024 ● Search Scopus @ Elsevier (DOI): 10.24479/kd.0000000586 (DOI: 10.24479/kd.0000000586, CiNii: 1390016195131521024)
12.	友雅司, Michio Mineshima, Shu Wakino and 武本佳昭 : 血液透析濾過器の性能評価と使い分け, J. Jpn. Soc. Dial. Ther., Vol.56, No.3, 83-84, 2023. (Tokushima University Institutional Repository) ● Metadata: 119552 (Link to Publication Site) ● Publication site (DOI): 10.4009/jsdt.56.83 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390858518834673280 ● Search Scopus @ Elsevier (DOI): 10.4009/jsdt.56.83 (Tokushima University Institutional Repository: 119552, DOI: 10.4009/jsdt.56.83, CiNii: 1390858518834673280)
13.	友雅司, Michio Mineshima, Shu Wakino and 武本佳昭 : 血液浄化器(中空糸型)の機能分類2023, J. Jpn. Soc. Dial. Ther., Vol.56, No.12, 537-540, 2023. (Tokushima University Institutional Repository) ● Metadata: 119553 (Link to Publication Site) ● Publication site (DOI): 10.4009/jsdt.56.537 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390298610032212480 ● Search Scopus @ Elsevier (DOI): 10.4009/jsdt.56.537 (Tokushima University Institutional Repository: 119553, DOI: 10.4009/jsdt.56.537, CiNii: 1390298610032212480)
14.	Shu Wakino : 【腎臓症候群(第3版)-その他の腎臓疾患を含めて-】各種病態にみられる腎障害肝疾患,消化管疾患炎症性腸疾患に伴う腎障害, Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.III, 254-258, Oct. 2022.
15.	Masanori Tamaki and Shu Wakino : 透析患者の血圧はどこまで下げるべきでしょうか?, Internal Medicine, Vol.130, No.3, 612-614, Sep. 2022. (Link to Publication Site) ● Publication site (DOI): 10.15106/j_naika130_612 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390293180218739584 ● Search Scopus @ Elsevier (DOI): 10.15106/j_naika130_612 (DOI: 10.15106/j_naika130_612, CiNii: 1390293180218739584)
16.	Shu Wakino : 【栄養指導・管理のためのスキルアップシリーズ CKDの最新食事療法のなぜに答える-透析編】透析患者では，どのような微量元素が欠乏するリスクがあるでしょうか? それはなぜですか?食事療法で補えますか?, 臨床栄養, 62-67, Jul. 2022.
17.	Kazuhiro Hasegawa and Shu Wakino : 【ポドサイトパチー】糖尿病性腎症におけるポドサイト傷害の見える化へ迫る最新論文, Nephrology, Vol.15, No.6, 659-664, Jun. 2022. (Keyword) podocytopathy / podocyte injury / DKD (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520011108762623872 (CiNii: 1520011108762623872)
18.	Shu Wakino : 【予防医学からみた腎疾患診療】CKDの発症・進展と合併症のリスクとされるエビデンス糖代謝異常インスリン抵抗性と腎障害, Kidney and Dialysis, Vol.92, No.5, 853-859, May 2022. (Link to Publication Site) ● Publication site (DOI): 10.24479/kd.0000000171 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390295658318517120 ● Search Scopus @ Elsevier (DOI): 10.24479/kd.0000000171 (DOI: 10.24479/kd.0000000171, CiNii: 1390295658318517120)
19.	Kazuhiro Hasegawa, Masanori Tamaki, 坂巻裕介 and Shu Wakino : ミトコンドリアとSIRT1/NMNと腎臓病, Nephrology, Vol.15, No.5, 551-557, May 2022. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520292395539278336 (CiNii: 1520292395539278336)
20.	Shu Wakino : 【かかりつけ医からみた糖尿病診療】糖尿病診療における合併症の管理糖尿病性腎臓病, 診断と治療, Vol.110, No.3, 313-319, Mar. 2022. (Link to Publication Site) ● Publication site (DOI): 10.34433/j00697.2022138874 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390294883135088512 ● Search Scopus @ Elsevier (DOI): 10.34433/j00697.2022138874 (DOI: 10.34433/j00697.2022138874, CiNii: 1390294883135088512)
21.	Shu Wakino : 亜鉛欠乏症と慢性腎臓病, Journal of Zinc Nutritional Therapy, Vol.12, No.2, 94-97, Mar. 2022. (Keyword) 微量元素 / Zinc / chronic kidney disease / intervention / infection / trace element (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520573881073212800 (CiNii: 1520573881073212800)
22.	Shaw Watanabe, Kyoka Adachi, Shu Wakino, Takahisa Hisada and Jun Mochizuki : Dietary therapy with low protein genmai (brown rice) to improve the gut-kidney axis and reduce CKD progression., Asia Pacific Journal of Clinical Nutrition, Vol.31, No.3, 341-347, 2022. (Summary) Low protein rice can be part of a nutritionally adequate dietary pattern in the prevention of chronic kidney disease. We developed a low protein fermented genmai (brown rice) LPFG) to improve chronic kidney disease (CKD) management. The principal functional features of brown rice are retained in LPFG, lessening the negative spiral of gut-kidney associative spiral attributable to uremic dysbiosis and a leaky gut. LPFG is characterized by (1) an energy value the same as white rice, (2) a protein content less than 0.2 g/ 100 g, (3) a potassium content almost zero, (4) phosphorus less than a quarter that of conventional rice, (5) the presence of dietary fiber, (6) having γ-oryzanol, and (7) antioxidant activity. Dietary therapy for CKD patients is challenged by the joint needs to provide enough energy and to restrict protein. Patients replaced staple foods with LPFG without side dish restriction. Preliminary study of intervention with 3 months of LPFG reduced constipation probably by increased Blautia wexlerae, Bifidobacteria, acetic acid, and a decrease in potentially harmful bacteria. Protein intake decreased from 60 to 50 g per day. Urinary protein excretion decreased from 510 to 300 mg per day, and β2-microglobulin from 926 to 250 μg/L. Adherence to the LPFG diet enabled improvement in glomerular and tubular function. (Keyword) Antioxidants / Diet / Dietary Fiber / Humans / Kidney / Oryza / Phosphorus / Potassium / Renal Insufficiency, Chronic (Tokushima University Institutional Repository) ● Metadata: 118480 (Link to Publication Site) ● Publication site (DOI): 10.6133/apjcn.202209_31(3).0001 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36173205 ● Search Scopus @ Elsevier (PMID): 36173205 ● Search Scopus @ Elsevier (DOI): 10.6133/apjcn.202209_31(3).0001 (Tokushima University Institutional Repository: 118480, DOI: 10.6133/apjcn.202209_31(3).0001, PubMed: 36173205)

Proceeding of International Conference:

1.	Hamamoto Riko, Hirokazu Ohminami, Shu Wakino and Yutaka Taketani : Effectiveness of protein restriction diet on chronic kidney disease: a systematic review, The International Workshop on Gut-kidney Axis and Chronic Kidney Disease, Tokyo, Mar. 2023.

Proceeding of Domestic Conference:

1.	古川安志, 田中景子, 磯崎収, Shu Wakino and 赤水尚史 : 甲状腺クリーゼ多施設前向きレジストリー研究診療ガイドライン2017による予後改善, Folia endocrinologica Japonica, Vol.100, No.1, 302, May 2024.
2.	古川安志, 赤水尚史, 磯崎収, 鈴木敦詞 and Shu Wakino : 甲状腺クリーゼ多施設前向きレジストリー研究の結果報告, Folia endocrinologica Japonica, Vol.99, No.5, 1222, Apr. 2024.
3.	Shu Wakino, 柴田理恵子, Kazuhiro Hasegawa, Masanori Tamaki, Masanori Minato, Taizo Inagaki, 宮上慎司, 多田美穂 and Ichiro Hashimoto : 皮膚虚血・潰瘍病変患者における血中亜鉛濃度の意義, 第53回徳島透析療法研究会, Dec. 2023.
4.	Shu Wakino and Kazuhiro Hasegawa : 教育講演糖尿病性腎臓病の治療の進歩, 日本内科学会雑誌, Vol.112, No.9, 1680-1689, Sep. 2023. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520016184419352832 (CiNii: 1520016184419352832)
5.	宮上慎司, Masanori Tamaki, Miho Tada, 山口純代 and Shu Wakino : ステロイドとリツキシマブが奏功したキャッスルマン病合併HIV関連免疫複合体腎臓病の一例, Japanese Journal of Nephrology, Vol.65, No.6-W, 744, Sep. 2023.
6.	Shu Wakino : 糖尿病性腎症から慢性腎臓病治療への新規治療戦略, 四国医学雑誌, Vol.79, No.1-2, 132-133, Jun. 2023.
7.	Shu Wakino : 透析患者の栄養管理, 医工学治療, Vol.35, No.Suppl., 150, May 2023.
8.	細島康宏, 蒲澤秀門, 村山稔子, 神田英一郎 and Shu Wakino : 現時点において求められる透析患者の栄養課題に関する臨床研究, Journal of Japanese Society for Dialysis Therapy, Vol.56, No.Suppl.1, 380, May 2023.
9.	山口純代, Masanori Tamaki, 宮上慎司, Eriko Shibata and Shu Wakino : アンモニア除去に苦慮した55歳発症尿素サイクル異常症の1例, Journal of Japanese Society for Dialysis Therapy, Vol.56, No.Suppl.1, 431, May 2023.
10.	Shu Wakino, Eriko Shibata, Masanori Minato, Ikuko Shimizu and Kazuhiro Hasegawa : 皮膚潰瘍病変患者における血中亜鉛濃度の意義, Journal of Japanese Society for Dialysis Therapy, Vol.56, No.Suppl.1, 566, May 2023.
11.	Shu Wakino, Kazuhiro Hasegawa and Masanori Tamaki : AKD(acute kidney disease and disorders)を考える透析導入阻止のためのAKD治療戦略, Japanese Journal of Nephrology, Vol.65, No.3, 231, May 2023.
12.	Masanori Tamaki, 越智ありさ, Tatsuya Tominaga, Eriko Shibata and Shu Wakino : Parkinは糖尿病やBMP4が惹起するミトコンドリアターンオーバー障害の治療標的である, Japanese Journal of Nephrology, Vol.65, No.3, 251, May 2023.
13.	吉村憲人, 神田武志, 山田勝利, 小野隆 and Shu Wakino : NAD+代謝物N-Me-2PYはPI3K-Akt経路の抑制を介して腎線維化進展を抑制する, Japanese Journal of Nephrology, Vol.65, No.3, 306, May 2023.
14.	Kazuhiro Hasegawa, Masanori Tamaki and Shu Wakino : 心血管内分泌の新知見尿細管糸球体連関とDKD, Folia endocrinologica Japonica, Vol.99, No.1, 171, May 2023.
15.	古川安志, 赤水尚史, 佐藤哲郎, 磯崎収, 鈴木敦詞, 飯降直男, 坪井久美子, Shu Wakino, 手良向聡, 金本巨哲, 三宅吉博, 田中景子, 木村映善, 南谷幹史 and 井口守丈 : 甲状腺クリーゼ多施設前向きレジストリー研究の経過報告, Folia endocrinologica Japonica, Vol.98, No.5, 1272, Mar. 2023.
16.	Shu Wakino : 糖尿病性腎臓病の治療の進歩, The Journal of the Japanese Society of Internal Medicine, Vol.112, 120-121, Feb. 2023.
17.	Masanori Minato, Ikuko Shimizu, Masanori Tamaki, Kazuhiro Hasegawa and Shu Wakino : 長時間のAPDにより至適透析を得た重度の精神発達遅滞を有する一例, Journal of Japanese Society for Dialysis Therapy, Vol.56, No.Suppl.1, 563, 2023.
18.	越智ありさ, Akiko Sakurai, 太田浩二, 飛永恭兵, RYUYA Wakabayashi, Shu Wakino, Koichi Ute and Tatsuya Tominaga : A new purification method for exosome, using highly water-absorbing polymer., 第45回日本分子生物学会年会, Dec. 2022.
19.	Yohjiroh Sunada, Sayo Ueda, Masanori Tamaki, Eriko Shibata and Shu Wakino : 胃癌による二次性血栓性微小血管症(TMA)の一例, Shikoku Acta Medica, Vol.78, No.5-6, 257-258, Dec. 2022.
20.	Kazuhiro Hasegawa, Masanori Tamaki and Shu Wakino : 時間空間的ネットワークで考えるDKDの基礎研究尿細管糸球体クロストークとDKD, Japanese Journal of Nephrology, Vol.64, No.6-W, 696, Oct. 2022.
21.	Masanori Tamaki, 宮上慎司, Ikuko Shimizu, 山口純代, Masanori Minato, Sayo Ueda, Eriko Shibata, Kazuhiro Hasegawa and Shu Wakino : ロキサデュスタット投与後に奇異性脳塞栓を発症した1例, Japanese Journal of Nephrology, Vol.64, No.6-W, 719, Oct. 2022.
22.	宮上慎司, Masanori Tamaki, Ikuko Shimizu, 山口純代, Masanori Minato, Sayo Ueda, Eriko Shibata, Kazuhiro Hasegawa and Shu Wakino : コロナウィルスワクチン後発症した悪性腎硬化症の一例, Japanese Journal of Nephrology, Vol.64, No.6-W, 719, Oct. 2022.
23.	Shu Wakino, 安達京華, 渡邊昌 and 伊藤裕 : 低蛋白玄米の腎不全患者への効果, New Diet Therapy, Vol.38, No.2, 223, Sep. 2022.
24.	Shu Wakino, 安達京華, 渡邊昌 and 伊藤裕 : 長野県佐久地域における健常腎保持者の摂取蛋白源に関する検討, New Diet Therapy, Vol.38, No.2, 229, Sep. 2022.
25.	Shu Wakino : 微量元素セレンの臨床的重要性, The Japanese Journal of Surgical Metabolism and Nutrition, Vol.56, No.3, 117, Jun. 2022.
26.	Kazuhiro Hasegawa, Masanori Tamaki, 坂巻裕介 and Shu Wakino : 腎臓病治療に対する新たな切り口 DMミトコンドリア機能改善薬やNADがDKDのみならず腎臓病への切り口となる可能性, Japanese Journal of Nephrology, Vol.64, No.3, 189, May 2022.
27.	Shu Wakino, Kazuhiro Hasegawa and 伊藤裕 : DKDに立ち向かう-これまでの100年とこれからの未来- DKD基礎研究の歩みと先端医療, Japanese Journal of Nephrology, Vol.64, No.3, 189, May 2022.
28.	Kazuhiro Hasegawa, Masanori Tamaki, 坂巻裕介 and Shu Wakino : NMN消費酵素Nmnatのポドサイト発現調節はE-boxへのepigenetic制御が担う, Japanese Journal of Nephrology, Vol.64, No.3, 228, May 2022.
29.	Masanori Tamaki, 宮上慎司, Ikuko Shimizu, 山口純代, Masanori Minato, Sayo Ueda, Eriko Shibata, Motoyuki Tamaki, Motoyuki Tamaki, Kazuhiro Hasegawa, Kojiro Nagai and Shu Wakino : ESAからロキサデュスタットへ切り替えた保存期CKD症例の解析, Japanese Journal of Nephrology, Vol.64, No.3, 257, May 2022.
30.	Kazuhiro Hasegawa, Masanori Tamaki, 坂巻裕介 and Shu Wakino : FSGSへのNMN短期集中投与はNMN・NAD消費酵素の暴走連関を抑制し糸球体硬化を抑止する, Japanese Journal of Nephrology, Vol.64, No.3, 263, May 2022.
31.	菅野義彦 and Shu Wakino : Minor nutrientsの管理日本臨床栄養学会の活動, Journal of Japanese Society for Dialysis Therapy, Vol.55, No.Suppl.1, 299, May 2022.
32.	Shu Wakino and 岡田一義 : 透析専門医の地域偏在解消に向けての取り組み, Journal of Japanese Society for Dialysis Therapy, Vol.55, No.Suppl.1, 395, May 2022.
33.	Sayo Ueda, Eriko Shibata, Masanori Tamaki, Masanori Minato, 岩城真帆, Ikuko Shimizu, 山口純代, 宮上慎司, Kazuhiro Hasegawa and Shu Wakino : 急性間質性腎炎を認めた敗血症性AKIの症例, Journal of Japanese Society for Dialysis Therapy, Vol.55, No.Suppl.1, 507, May 2022.
34.	Masanori Tamaki, 宮上慎司, 岩城真帆, Ikuko Shimizu, 山口純代, Masanori Minato, Sayo Ueda, Eriko Shibata, Kojiro Nagai, Kazuhiro Hasegawa and Shu Wakino : 腹膜透析導入後に膵癌を発症した1例, Journal of Japanese Society for Dialysis Therapy, Vol.55, No.Suppl.1, 631, May 2022.
35.	Ikuko Shimizu, Masanori Tamaki, 宮上慎司, 山口純代, Masanori Minato, Sayo Ueda, Eriko Shibata, Kazuhiro Hasegawa and Shu Wakino : 慢性大動脈解離に伴う慢性DICのため腎代替療法導入に苦慮した1例, Journal of Japanese Society for Dialysis Therapy, Vol.55, No.Suppl.1, 663, May 2022.
36.	北島幸枝, 松永智仁 and Shu Wakino : Total Nutrition Therapy-RENAL研修会の開催と今後の展望, Journal of Japanese Society for Dialysis Therapy, Vol.55, No.Suppl1, 725, May 2022.
37.	Shu Wakino, 内藤真規子, 二木功治, 徳山博文 and 伊藤裕 : 代謝制御臓器としての腎臓と肥満肥満における腎障害の分子機序の解明, Journal of Japan Society for the Study of Obesity, Vol.27, No.Suppl, 210, Mar. 2022.
38.	神田武志, 浦井秀徳, 高橋利奈, Shu Wakino and 伊藤裕 : 肥満腎症における内皮レプチンシグナルの役割, Journal of Japan Society for the Study of Obesity, Vol.27, No.Suppl, 326, Mar. 2022.
39.	Masanori Tamaki, 宮上慎司, 岩城真帆, 清水郁子, 山口純代, 湊将典, Sayo Ueda, Eriko Shibata, Kazuhiro Hasegawa, Kojiro Nagai and Shu Wakino : 膵癌を合併した腹膜透析患者の1例, 第27回日本腹膜透析医学会学術集会・総会, Oct. 2021.
40.	宮上慎司, Masanori Tamaki, Kenji Nishimura, 岩城真帆, 清水郁子, 山口純代, Sayo Ueda, Eriko Shibata, Hideharu Abe, Kojiro Nagai and Shu Wakino : 繰り返す菌血症に対し予防的抗菌薬投与が奏功した1例, Journal of Japanese Society for Dialysis Therapy, Jun. 2021.
41.	Yuichi Takashi, Masashi Ishizu, Shu Wakino, 水口斉, 島久登, 田代学, 宮恵子, 水口潤, Akio Kuroda, Toshio Matsumoto, Munehide Matsuhisa and Seiji Fukumoto : 血液透析患者における心不全・動脈硬化・感染のリスク因子としてのFGF23, 第18回日本内分泌学会四国支部学術集会, Sep. 2018.

Et cetera, Workshop:

1.	Masanori Tamaki, 湊将典, 宮上慎司, 岩城真帆, 清水郁子, 山口純代, Sayo Ueda, Eriko Shibata, Kazuhiro Hasegawa and Shu Wakino : ステントグラフト留置術がAVG頻回閉塞に有用であった一例, 第55回四国透析療法研究会, Oct. 2021.
2.	遠藤理子, 宮上慎司, 湊将典, Masanori Tamaki, 岩城真帆, 清水郁子, 山口純代, Sayo Ueda, Eriko Shibata, Kazuhiro Hasegawa and Shu Wakino : 膜性腎症に合併したIgG4関連腎臓病の一例, 第263回徳島医学会, Aug. 2021.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

多元的フェロトーシス治療に基づく慢性腎臓病治療戦略の開発 (Project/Area Number: 23K07674 )
Spiral progression of DNA damage repair, epigenetic alterations and metabolic changes in metabolic kidney diseases (Project/Area Number: 20H00535 )
Pathophysiology of obesity related glomerulopathy (Project/Area Number: 18K08218 )
The significant role of the kidney as a central organ for metabolic organ interrelationship (Project/Area Number: 17H01562 )
The pathophysiology of diabetic tubulopathy and therapeutic application (Project/Area Number: 16H05315 )
The therapeutic starategy by Ghrelin targeting against mitochondria dynamics (Project/Area Number: 26670433 )
Pathophysiology of non-diabetic/obesity induced renal injuries (Project/Area Number: 26461236 )
Tubular- glomerular interaction nd metabolic kidney disease (Project/Area Number: 26253053 )
The role of endothelial leptin receptor in lifestyle-related diseases. (Project/Area Number: 25461396 )
The significance of proximal tubular lesion in diabetic nephropathy and obesity-related glomerulopathy (Project/Area Number: 25293197 )
The role of stretch signal induced by the adipocytes hypertrophy and activation of Rho/Rho kinase pathway in the pathogenesis of obesity (Project/Area Number: 22591017 )
Therapeutic strategy for chronic kidney disease and hypertension based on time/metabolism regulation. (Project/Area Number: 22590915 )
Pathophysiological relevance of visceral fat and kidneys in obesity-induced renal injury (Project/Area Number: 22590898 )
Regulation of cell-metabolism by cardiovascular hormones and the comprehensive application to metabolic syndrome. (Project/Area Number: 21390286 )
Metabolism of ADMA, a novel risk factor of cardiovascular diseases and its pathophysiological role (Project/Area Number: 20590582 )
Anti-aging therapy against chronic kidney disease (Project/Area Number: 19590963 )
Cardiovascular-endocrinological approach for elucidation of the molecular mechanism of "Metabo-aging" (Project/Area Number: 19390255 )
The role of Rho/Rho kinase pathway in the metabolic syndrome-associated renal insufficiency (Project/Area Number: 18590904 )
The investigation of inducing factors of cardiovascular events in early stage of chronic kidney disease (Project/Area Number: 16590716 )
Search by Researcher Number (50265823)

Professor : Wakino, Shu

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)