徳島大学 / 教育研究者総覧 --- 生田目大介

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徳島大学 ⟩ 大学院医歯薬学研究部 ⟩ 歯学域 ⟩ 口腔科学部門 ⟩ 臨床歯学系 ⟩ 顎機能咬合再建学 ⟩
徳島大学 ⟩ 歯学部 ⟩ 歯学科 ⟩ 機能維持系臨床歯学講座 ⟩ 顎機能咬合管理学 ⟩
徳島大学 ⟩ 病院 ⟩ 診療科 ⟩ 歯科 ⟩ かみあわせ補綴科(第二補綴科) ⟩

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研究活動

専門分野

○	歯科補綴学 (Prosthodontics)

研究テーマ

○	筋痛モデルラットによる咀嚼筋痛受容機構解明ならびに治療法開発の基盤形成 (咬筋痛, 線維筋痛症, グリア細胞, 炎症性サイトカイン (inflammatory cytokine), ミノサイクリン, レセルピン)

著書・論文

学術論文(審査論文):

1.	Yoshitaka Suzuki, Kazuo Okura, Toyoko Tajima, Junhel Dalanon, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Mayu Miyagi, Daisuke Ikutame and Yoshizo Matsuka : Essence of diagnosis and management of sleep bruxism, Journal of Oral Health and Biosciences, Vol.36, No.2, 22-29, 2024.
2.	S Raman, Daisuke Ikutame, Kazuo Okura and Yoshizo Matsuka : Targeted therapy for orofacial pain: A novel perspective for precision medicine, Journal of Personalized Medicine, Vol.13, No.3, 565, 2023. (要約) Orofacial pain (OFP) is a dental specialty that includes the diagnosis, management and treatment of disorders of the jaw, mouth, face, head and neck. Evidence-based understanding is critical in effectively treating OFPs as the pathophysiology of these conditions is multifactorial. Since OFP impacts the quality of life of the affected individuals, treating patients successfully is of the utmost significance. Despite the therapeutic choices available, treating OFP is still quite challenging, owing to inter-patient variations. The emerging trends in precision medicine could probably lead us to a paradigm shift in effectively managing the untreatable long-standing pain conditions. Precision medicine is designed based on the patient's genetic profile to meet their needs. Several significant relationships have been discovered based on the genetics and genomics of pain in the past, and some of the notable targets are discussed in this review. The scope of this review is to discuss preclinical and clinical trials that include approaches used in targeted therapy for orofacial pain. Future developments in pain medicine should benefit from current trends in research into novel therapeutic approaches. (徳島大学機関リポジトリ) ● Metadata: 118082 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/jpm13030565 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36983746 ● Search Scopus @ Elsevier (PMID): 36983746 ● Search Scopus @ Elsevier (DOI): 10.3390/jpm13030565 (徳島大学機関リポジトリ: 118082, DOI: 10.3390/jpm13030565, PubMed: 36983746)
3.	S Raman, Arief Waskitho, R Raju, Takuma Iwasa, Daisuke Ikutame, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka : Analgesic effect of tranilast in an animal model of neuropathic pain and its role in the regulation of tetrahydrobiopterin synthesis, International Journal of Molecular Sciences, Vol.23, No.11, 5878, 2022. (徳島大学機関リポジトリ) ● Metadata: 118650 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ijms23115878 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.3390/ijms23115878 (徳島大学機関リポジトリ: 118650, DOI: 10.3390/ijms23115878)
4.	Arief Waskitho, Yumiko Yamamoto, S Raman, Fumiya Kano, Huijiao Yan, R Raju, S Afroz, Tsuyoshi Morita, Daisuke Ikutame, Kazuo Okura, Masamitsu Ohshima, Akihito Yamamoto, Otto Baba and Yoshizo Matsuka : Peripherally Administered Botulinum Toxin Type A Localizes Bilaterally in Trigeminal Ganglia of Animal Model, Toxins, Vol.13, No.10, 704, 2021. (徳島大学機関リポジトリ) ● Metadata: 116383 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/toxins13100704 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.3390/toxins13100704 (徳島大学機関リポジトリ: 116383, DOI: 10.3390/toxins13100704)
5.	Daisuke Ikutame, Kentaro Urata, Tatsuki Oto, Shintaro Fujiwara, Toshimitsu Iinuma, Ikuko Shibuta, Yoshinori Hayashi, Suzuro Hitomi, Koichi Iwata and Masamichi Shinoda : Aging-Related Phenotypic Conversion of Medullary Microglia Enhances Intraoral Incisional Pain Sensitivity., International Journal of Molecular Sciences, Vol.21, No.21, 2020. (要約) Activated microglia involved in the development of orofacial pain hypersensitivity have two major polarization states. The aim of this study was to assess the involvement of the aging-related phenotypic conversion of medullary microglia in the enhancement of intraoral pain sensitivity using senescence-accelerated mice (SAM)-prone/8 (SAMP8) and SAM-resistant/1 (SAMR1) mice. Mechanical head-withdrawal threshold (MHWT) was measured for 21 days post palatal mucosal incision. The number of CD11c-immunoreactive (IR) cells [affective microglia (M1)] and CD163-IR cells [protective microglia (M2)], and tumor-necrosis-factor-α (TNF-α)-IR M1 and interleukin (IL)-10-IR M2 were analyzed via immunohistochemistry on days 3 and 11 following incision. The decrease in MHWT observed following incision was enhanced in SAMP8 mice. M1 levels and the number of TNF-α-IR M1 were increased on day 3 in SAMP8 mice compared with those in SAMR1 mice. On day 11, M1 and M2 activation was observed in both groups, whereas IL-10-IR M2 levels were attenuated in SAMP8 mice, and the number of TNF-α-IR M1 cells increased, compared to those in SAMR1 mice. These results suggest that the mechanical allodynia observed following intraoral injury is potentiated and sustained in SAMP8 mice due to enhancement of TNF-α signaling, M1 activation, and an attenuation of M2 activation accompanying IL-10 release. (キーワード) 加齢 (aging) / Animals / Antigens, CD / Antigens, Differentiation, Myelomonocytic / CD11 Antigens / Disease Models, Animal / Facial Pain / Interleukin-10 / 男性 (male) / Mice / Microglia / Phenotype / Receptors, Cell Surface / シグナル伝達 (signal transduction) / Tumor Necrosis Factor-alpha (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ijms21217871 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33114176 ● Search Scopus @ Elsevier (PMID): 33114176 ● Search Scopus @ Elsevier (DOI): 10.3390/ijms21217871 (DOI: 10.3390/ijms21217871, PubMed: 33114176)
6.	Masamichi Shinoda, Satoshi Fujita, Shiori Sugawara, Sayaka Asano, Ryo Koyama, Shintaro Fujiwara, Kumi Soma, Takaaki Tamagawa, Tomoyuki Matsui, Daisuke Ikutame, Masatoshi Ando, Ayaka Osada, Yuki Kimura, Kazutaka Kobayashi, Takamitsu Yamamoto, Kuniko Kusama-Eguchi, Masayuki Kobayashi, Yoshinori Hayashi and Koichi Iwata : Suppression of Superficial Microglial Activation by Spinal Cord Stimulation Attenuates Neuropathic Pain Following Sciatic Nerve Injury in Rats., International Journal of Molecular Sciences, Vol.21, No.7, 2020. (要約) We evaluated the mechanisms underlying the spinal cord stimulation (SCS)-induced analgesic effect on neuropathic pain following spared nerve injury (SNI). On day 3 after SNI, SCS was performed for 6 h by using electrodes paraspinally placed on the L4-S1 spinal cord. The effects of SCS and intraperitoneal minocycline administration on plantar mechanical sensitivity, microglial activation, and neuronal excitability in the L4 dorsal horn were assessed on day 3 after SNI. The somatosensory cortical responses to electrical stimulation of the hind paw on day 3 following SNI were examined by using in vivo optical imaging with a voltage-sensitive dye. On day 3 after SNI, plantar mechanical hypersensitivity and enhanced microglial activation were suppressed by minocycline or SCS, and L4 dorsal horn nociceptive neuronal hyperexcitability was suppressed by SCS. In vivo optical imaging also revealed that electrical stimulation of the hind paw-activated areas in the somatosensory cortex was decreased by SCS. The present findings suggest that SCS could suppress plantar SNI-induced neuropathic pain via inhibition of microglial activation in the L4 dorsal horn, which is involved in spinal neuronal hyperexcitability. SCS is likely to be a potential alternative and complementary medicine therapy to alleviate neuropathic pain following nerve injury. (キーワード) Animals / 男性 (male) / Microglia / Neuralgia / Peripheral Nerve Injuries / Rats / Rats, Sprague-Dawley / Sciatic Nerve / Spinal Cord Stimulation (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ijms21072390 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32235682 ● Search Scopus @ Elsevier (PMID): 32235682 ● Search Scopus @ Elsevier (DOI): 10.3390/ijms21072390 (DOI: 10.3390/ijms21072390, PubMed: 32235682)
7.	K Urata, M Shinoda, Daisuke Ikutame, T Iinuma and K Iwata : Involvement of transient receptor potential vanilloid 2 in intra-oral incisional pain., Oral Diseases, Vol.24, No.6, 1093-1100, 2018. (要約) The increased expression of TRPV2 in peptidergic TG neurons innervating the incisional buccal mucosa is predominantly involved in buccal mucosal heat hyperalgesia and mechanical allodynia following buccal mucosal incision. (キーワード) Animals / 男性 (male) / Mouth Mucosa / ペインコントロール (pain control) / Pain Threshold / Rats / Surgical Wound / TRPV Cation Channels / Thermosensing / Touch (出版サイトへのリンク) ● Publication site (DOI): 10.1111/odi.12853 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29505690 ● Search Scopus @ Elsevier (PMID): 29505690 ● Search Scopus @ Elsevier (DOI): 10.1111/odi.12853 (DOI: 10.1111/odi.12853, PubMed: 29505690)

学術論文(紀要・その他):

1.	松香芳三, 山本由弥子, Swarnalakshmi Raman, 生田目大介, 岩浅匠真, 大倉一夫 : 口腔顔面痛に対するボツリヌス毒素効果メカニズム, 日本口腔顔面痛学会雑誌, Vol.16, No.1, 21-24, 2024年.

国内講演発表:

1.	横井美有希, 安部倉仁, 森田晃司, 土井一矢, 細木眞紀, 宮城麻友, 井上美穂, 生田目大介, 中川晋輔, 秋山謙太郎, 縄稚久美子, 黒崎陽子, 松香芳三, 窪木拓男, 津賀一弘 : 最後方大臼歯へのPEEKクラウンの臨床応用についての6ヶ月間の評価, 日本補綴歯科学会雑誌, 2024年7月.
2.	Putra Lutfi Perdana, Swarna Lakshmi Raman, Fabillar Jr. Jaime Moreno, Arini Sari Dara, Masamitsu Ohshima, Daisuke Ikutame, Keiko Miyoshi and Yoshizo Matsuka : Pain-relief mechanism of IL-10 in the trigeminal ganglia: insights into trigeminal neuropathic pain management, Brain Science cluster minirtreat, Feb. 2024.
3.	生田目大介, 大倉一夫, 松香芳三 : 咀嚼筋痛モデルラットを用いた咀嚼筋痛受容機構の解明, 日本口腔顔面痛学会雑誌, 2023年11月.
4.	井上美穂, 大島正充, 宮城麻友, 生田目大介, 松香芳三 : 口腔顔面痛はアロマテラピーで軽減する∼口腔顔面痛モデル動物での評価∼, 日本補綴歯科学会雑誌, 2023年5月.
5.	細木眞紀, 生田目大介, 宮城麻友, 大倉一夫, 井上美穂, 小澤彩, 柴垣あかり, 谷脇竜弥, 鴨居浩平, 板東伸幸, 吉原靖智, 大島正充, 鈴木善貴, 新開瑞希, 松香芳三 : デジタル化に対応したクラウンブリッジ補綴学実習の検討, 日本補綴歯科学会雑誌, 2023年5月.
6.	蓮池真由子, 井上美穂, Swarna Raman, Jaime M.Fabillar, Lutfi P.Perdana, 宮城麻友, 生田目大介, 大島正充, 松香芳三 : 口腔顔面痛モデル動物を用いた精油嗅覚刺激の疼痛抑制効果∼ベルガモット，ラベンダーの検討∼, 四国歯学会雑誌, 2023年3月.
7.	Jr.M.Fabillar Jaime, Raman Swarna, P.Perdana Lutfi, Daisuke Ikutame, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka : Bilateral transport of neuronal tracer after unilateral administration, 徳島大学脳科学クラスター・ミニリトリート, Feb. 2023.
8.	井上美穂, Swarna Raman, Jaime Jr.M.Fabillar, 蓮池真由子, Lutfi P.Perdana, 井上正久, 生田目大介, 宮城麻友, 大島正充, 松香芳三 : 精油成分による口腔顔面痛モデル動物の痛み軽減とメカニズム, 徳島大学脳科学クラスター・ミニリトリート, 2023年2月.
9.	細木眞紀, 生田目大介, 宮城麻友, 大倉一夫, 井上美穂, 小澤彩, 柴垣あかり, 谷脇竜弥, 鴨居浩平, 板東伸幸, C. Riquelme, 吉原靖智, 大島正充, 鈴木善貴, 新開みずき, 松香芳三 : デジタル化が進む歯科診療の現状紹介と歯科補綴学実習における学習内容の検討, 大学教育カンファレンスin徳島, 2022年12月.
10.	大倉一夫, 井上美穂, 鈴木善貴, 細木眞紀, 生田目大介, 安陪晋, 河野文昭, 松香芳三 : アクティブラーニングの学修効果 ―オンライン授業と通常授業，TBL授業の比較―, 日本歯科医学教育学会雑誌, 2022年7月.
11.	細木眞紀, 大倉一夫, 井上美穂, 鈴木善貴, 生田目大介, 安陪晋, 河野文昭, 松香芳三 : 2021年度歯科補綴学実習の評価, 日本歯科医学教育学会雑誌, 2022年7月.
12.	大倉一夫, 葉山莉香, 大島正充, 細木眞紀, 鈴木善貴, 宮城麻友, 井上美穂, 生田目大介, 田島登誉子, 吉原靖智, 小澤彩, 新開瑞希, 松香芳三 : 歯科補綴学におけるアクティブラーニングの学修効果反転授業とTBL，通常授業の比較, 日本補綴歯科学会雑誌, 2022年7月.
13.	Raman Swarna Lakshmi, Waskitho Arief, Kazuo Okura, Daisuke Ikutame, Masamitsu Ohshima and Yoshizo Matsuka : Evaluation of tetrahydrobiopterin pathway in orofacial pain model, Feb. 2022.
14.	Waskitho Arief, Yumiko Yamamoto, Raman Swarna Lakshmi, Fumiya Kano, Huijiao Yan, Kazuo Okura, Daisuke Ikutame, Masamitsu Ohshima, Otto Baba, Akihito Yamamoto and Yoshizo Matsuka : Bilateral botulinum toxin type A effect on orofacial neuropathic pain of animal model, 徳島大学脳科学クラスターミニリトリート, Feb. 2022.
15.	大倉一夫, 葉山莉香, 大島正充, 細木眞紀, 鈴木善貴, 井上美穂, 生田目大介, 吉原靖智, 新開瑞希, 小澤彩, 松香芳三 : 歯科補綴学授業におけるアクティブラーニングの学修効果―オンライン授業と通常授業，TBL授業の比較―, 大学教育カンファレンス in 徳島, 2022年1月.
16.	細木眞紀, 西川泰史, 生田目大介, 大島正充, 井上美穂, 小澤彩, 新開瑞希, RAMAN SWARNA LAKSHMI, RAVINDRA PARIMAL CHAVAN, 吉原靖智, 大倉一夫, 鈴木善貴, 松香芳三 : COVID-19対策が日常となった2021年度歯科補綴学実習の評価, 大学教育カンファレンス in 徳島, 2022年1月.

その他・研究会:

1.	Lutfi P. Perdana, Swarnalakshmi Raman, Jaime Jr. Fabillar, Dara S. Arini, Masamitsu Ohshima, Daisuke Ikutame, Keiko Miyoshi and Yoshizo Matsuka : Antinociceptive mechanism of IL-10 in trigeminal ganglia of trigeminal neuropathic pain model, Feb. 2024.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

筋痛モデルラットによる咀嚼筋痛受容機構解明ならびに治療法開発の基盤形成 (研究課題/領域番号: 23K16069 )
歯科再生医療の実現に向けた再生器官サイズ・形態形成の分子メカニズムの解明と応用 (研究課題/領域番号: 22K10079 )
口腔顔面痛に対するBH4代謝経路活性と新規治療法の基盤形成 (研究課題/領域番号: 22H03281 )
筋痛モデルラットによる咀嚼筋痛受容機構解明ならびに治療法開発の基盤形成 (研究課題/領域番号: 21K21042 )
研究者番号（10910218）による検索