Tokushima University / Educator and Researcher Directory --- Naniwa, Kohei

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Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 歯学域 ⟩ 先端歯学教育研究プロジェクト ⟩
Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 歯学域 ⟩ Oral Science ⟩ Clinical Dentistry ⟩ Department of Comprehensive Dentistry ⟩
Tokushima University ⟩ Faculty of Dentistry ⟩ Course in Dentistry ⟩ Clinical Dentistry for Oral Health and Function ⟩ Comprehensive Dentistry ⟩

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Research

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Kohei Naniwa, Katsutoshi Hirose, Yu Usami, Kenji Hata, Rikita Araki, Narikazu Uzawa, Toshihisa Komori and Satoru Toyosawa : Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation., Journal of Molecular Histology, Vol.54, No.4, 329-347, 2023. (Summary) FAM20C phosphorylates secretory proteins at S-x-E/pS motifs, and previous studies of Fam20C-dificient mice revealed that FAM20C played essential roles in bone and tooth formation. Inactivation of FAM20C in mice led to hypophosphatemia that masks direct effect of FAM20C in these tissues, and consequently the direct role of FAM20C remains unknown. Our previous study reported that osteoblast/odontoblast-specific Fam20C transgenic (Fam20C-Tg) mice had normal serum phosphate levels and that osteoblastic FAM20C-mediated phosphorylation regulated bone formation and resorption. Here, we investigated the direct role of FAM20C in dentin using Fam20C-Tg mice. The tooth of Fam20C-Tg mice contained numerous highly phosphorylated proteins, including SIBLINGs, compared to that of wild-type mice. In Fam20C-Tg mice, coronal dentin volume decreased and mineral density unchanged at early age, while the volume unchanged and the mineral density elevated at maturity. In these mice, radicular dentin volume and mineral density decreased at all ages, and histologically, the radicular dentin had wider predentin and abnormal apical-side dentin with embedded cells and argyrophilic canaliculi. Immunohistochemical analyses revealed that abnormal apical-side dentin had bone and dentin matrix properties accompanied with osteoblast-lineage cells. Further, in Fam20C-Tg mice, DSPP content which is important for dentin formation, was reduced in dentin, especially radicular dentin, which might lead to defects mainly in radicular dentin. Renal subcapsular transplantations of tooth germ revealed that newly formed radicular dentin replicated apical abnormal dentin of Fam20C-Tg mice, corroborating that FAM20C overexpression indeed caused the abnormal dentin. Our findings indicate that odontoblastic FAM20C-mediated phosphorylation in the tooth regulates dentin formation and odontoblast differentiation. (Keyword) Mice / Animals / Odontoblasts / Mice, Transgenic / Tooth / Cell Differentiation / Extracellular Matrix Proteins / Dentin / Phosphoproteins / Calcium-Binding Proteins (Link to Publication Site) ● Publication site (DOI): 10.1007/s10735-023-10123-y (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37357253 ● Summary page in Scopus @ Elsevier: 2-s2.0-85162896363 (DOI: 10.1007/s10735-023-10123-y, PubMed: 37357253, Elsevier: Scopus)

Proceeding of International Conference:

1.	Hirose Katsutoshi, Kohei Naniwa, Hyodo Miho, Usami Yu, Abe Makoto, Hata Kenji, Inubushi Toshihiro and Toyosawa Satoru : Osteocytic constitutive activation of Gαs activity exerts an anabolic effect on the bone, ASBMR 2022 Annual Meeting, Sep. 2022.

Proceeding of Domestic Conference:

1.	Keiko Aota, Kohichi Kani, 西田真理 (名), Mami Sato-Fukuba, Kohei Naniwa and Yukihiro Momota : JAK阻害薬バリシチニブは唾液腺導管細胞のIFN-γ誘導性CXCL10発現を抑制する, 第59回日本口腔組織培養学会総会・学術大会, Nov. 2023.
2.	Kohichi Kani, 西田真理, 大山博行, Mami Sato-Fukuba, Kohei Naniwa, Hideyuki Takano, Yukihiro Momota and Keiko Aota : 上唇に発生した嚢胞腺腫の1例, 第68回口腔外科学会総会・学術大会, Nov. 2023.
3.	Mami Sato-Fukuba, Kohei Naniwa, Kohichi Kani, Yukihiro Momota and Keiko Aota : 不明熱を契機にシェーグレン症候群の診断に至った7歳女児例, 第70回 NPO法人日本口腔科学会中国・四国地方部会, Oct. 2023.
4.	Kohichi Kani, 西田真理, Masahiko Watanabe, 大山博行, Mami Sato-Fukuba, Kohei Naniwa, Yukihiro Momota and Keiko Aota : 急激な増大を呈した頬粘膜形質芽細胞性リンパ腫の1例, 第33回日本口腔内科学会・4学会合同学術大会, Sep. 2023.
5.	Kohei Naniwa, 大山博行, 西田真理, Mami Sato-Fukuba, Kohichi Kani, Yukihiro Momota and Keiko Aota : 多形滲出性紅斑の1例, 第52回口腔外科学会中四国支部学術大会, Jul. 2023.
6.	Kohichi Kani, 西田真理, 大山博行, Kohei Naniwa, Yukihiro Momota, Fumihiro Matsumoto and Keiko Aota : 歯痛を初発症状とした傍咽頭間隙原発悪性リンパ腫の1例, 第77回口腔科学会総会, May 2023.
7.	Kohei Naniwa, 金川裕子, Shinji Ono, Hideyuki Takano, 西田真理, 大山博行, Kohichi Kani, Fumihiro Matsumoto, Yukihiro Momota and Keiko Aota : 整形外科インプラント手術における周術期口腔機能管理の有効性の検討, 第20回口腔ケア学会総会・学術大会, Apr. 2023.
8.	Kohei Naniwa, 廣瀬勝俊, 宇佐美悠, 小守壽文, 豊澤悟 and Keiko Aota : 象牙質形成におけるFam20Cによるリン酸化の役割について, 第58回日本口腔組織培養学会学術大会, Dec. 2022.
9.	Kohei Naniwa, 西田真理, 大山博行, Hideyuki Takano, Kohichi Kani, Yukihiro Momota, Fumihiro Matsumoto and Keiko Aota : メトトレキサート休薬により良好な結果が得られた医原性リンパ増殖性疾患の一例, 第69回日本口腔科学会中四国地方部会, Oct. 2022.
10.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, NISHIDA Mari, 大山博行, Shinji Ono, Kohei Naniwa, Fumihiro Matsumoto and Keiko Aota : 徳島県における南海トラフ大地震による歯科医院被害予測と大学歯科に期待される役割, 第69回日本口腔科学会中国四国地方部会, Oct. 2022.
11.	Kohei Naniwa : Fam20C overexpression in odontoblasts regulates dentin mineralization and odontoblast differentiation, 令和3年度大阪大学歯学会優秀海外発表大学院生奨励賞受賞講演, Jul. 2022.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

シェーグレン症候群におけるFam20Cおよびオステオポンチンの役割の解明と治療への応用 (Project/Area Number: 23K16119 )
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