Tokushima University / Educator and Researcher Directory --- Hiroshima, Yuka

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Academic Paper (Judged Full Paper):

1.	Youichi Otomi, Takayoshi Shinya, Hideki Otsuka, Hiroto Kasai, Tomoki Matsushita, Yukiko Takaoka, Yuka Hiroshima, Tomoyasu Matsubara, Koji Fujita, Yukiko Tomioka, Masahito Nakataki, Shusuke Numata, Yuishin Izumi and Masafumi Harada : Serial amyloid PET demonstrates marked reduction in amyloid burden following donanemab treatment: a real-world cohort study, Japanese Journal of Radiology, 2026. (Summary) To evaluate changes in amyloid burden on serial amyloid PET before and after donanemab treatment in a real-world clinical cohort. This retrospective study included 20 consecutive patients who underwent serial amyloid PET before and after donanemab treatment. Quantitative analysis was performed using Centiloid values and tracer-specific standardized uptake value ratios (SUVr). Visual assessment was also performed to determine amyloid-positive or amyloid-negative status before and after treatment. Centiloid values significantly decreased from 52.3 ± 23.4 at baseline to - 5.6 ± 16.5 at follow-up, with a mean change of - 58.0 (p < 0.001). All patients showed a reduction in Centiloid values. In the flutemetamol group (n = 12), pons-referenced SUVr significantly decreased, while in the florbetapir group (n = 8), cerebellar-referenced SUVr also showed significant reductions (both p < 0.001). On visual assessment, 17 of 20 patients (85%) converted from amyloid-positive to amyloid-negative status after treatment. Serial amyloid PET demonstrated a substantial reduction in amyloid burden following donanemab treatment in this real-world cohort. Quantitative amyloid PET, particularly using Centiloid scaling, may be a useful tool for monitoring treatment response in clinical practice. (Keyword) Alzheimer's disease / Amyloid PET / Centiloid / Donanemab / Treatment response (Link to Publication Site) ● Publication site (DOI): 10.1007/s11604-026-02054-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 42507054 ● Summary page in Scopus @ Elsevier: 2-s2.0-105046210958 (DOI: 10.1007/s11604-026-02054-x, PubMed: 42507054, Elsevier: Scopus)
2.	Yoichi Otomi, Takayoshi Shinya, Hideki Otsuka, Yushi Kamei, Manduukhai Badarchin, Tomoki Matsushita, Yukiko Takaoka, Yuka Hiroshima, Tomoyasu Matsubara, Koji Fujita, Yukiko Tomioka, Masahito Nakataki, Shusuke Numata, Yuishin Izumi and Masafumi Harada : Quantitative agreement between AMYclz and CortexID for 18F-florbetapir amyloid PET: a retrospective study of 103 patients, Japanese Journal of Radiology, 2026. (Keyword) Alzheimer's disease / Amyloid PET / Centiloid scale / Quantification / SUVr (Link to Publication Site) ● Publication site (DOI): 10.1007/s11604-026-02026-1 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-105040939938 (DOI: 10.1007/s11604-026-02026-1, Elsevier: Scopus)
3.	Youichi Otomi, Takayoshi Shinya, Hiroto Kasai, Naoko Okada, Tomoki Matsushita, Kohei Higashi, Saya Matsuzaki, Yuka Hiroshima, Michiko Kubo, Hideki Otsuka and Masafumi Harada : F-FDG PET/CT after COVID-19 Vaccination: A Direct Comparison Study with Influenza Vaccination., Molecular Imaging and Radionuclide Therapy, 32, 1, 13-19, 2023. (Summary) F-FDG PET/CT examination is recommended by a longer interval from vaccination than in the influenza vaccine. (Link to Publication Site) ● Publication site (DOI): 10.4274/mirt.galenos.2022.27136 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36817634 ● Summary page in Scopus @ Elsevier: 2-s2.0-85149498023 (DOI: 10.4274/mirt.galenos.2022.27136, PubMed: 36817634, Elsevier: Scopus)
4.	Yuka Hiroshima, Youichi Otomi, Takayoshi Shinya, Hideki Otsuka and Masafumi Harada : F-FDG PET/CT in the Evaluation of Adult Alveolar Rhabdomyosarcoma., Molecular Imaging and Radionuclide Therapy, 32, 1, 62-64, 2023. (Summary) C-methionine PET/CT for accurately assessing the extent of alveolar rhabdomyosarcoma, especially in cases with intracranial infiltration or those approximating the brain. (Link to Publication Site) ● Publication site (DOI): 10.4274/mirt.galenos.2022.96977 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36819829 ● Search Scopus @ Elsevier (PMID): 36819829 ● Search Scopus @ Elsevier (DOI): 10.4274/mirt.galenos.2022.96977 (DOI: 10.4274/mirt.galenos.2022.96977, PubMed: 36819829)
5.	Takayoshi Shinya, Tomoki Matsushita, Yuka Hiroshima, Yoichi Otomi, Yasuhisa Kanematsu, Yoshimi Bando, Hisanori Uehara, Yoshiaki Kitamura and Masafumi Harada : Imaging features of a myoepithelial carcinoma of the nasal cavity: A case report and literature review, Radiology Case Reports, 18, 1, 386-391, 2023. (Keyword) Computed tomography / Hemorrhagic necrosis / Magnetic resonance imaging / Myoepithelial carcinoma / Nasal cavity / Positron emission tomography (Link to Publication Site) ● Publication site (DOI): 10.1016/j.radcr.2022.10.081 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85142414132 (DOI: 10.1016/j.radcr.2022.10.081, Elsevier: Scopus)

Proceeding of International Conference:

1.	Takayoshi Shinya, Matsushita Tomoki, Mitsuhashi Ryota, Saya Matsuzaki, Onishi Hajime, Yuka Hiroshima, Youichi Otomi, Michiko Kubo and Masafumi Harada : Usefulness of F-18 FDG PET/CT imaging in Hepatic Lesions, 13th Congress of the World Federation of Nuclear Medicine and Biology, Sep. 2022.

Proceeding of Domestic Conference:

1.	Yuka Hiroshima, Takayoshi Shinya, Badrakhzul Zayabat, Tomoki Matsushita, Junichiro Hiraoka, Youichi Otomi, Toshihiko Nishisho, Koichi Sairyo, Keisuke Ishizawa and Masafumi Harada : Dynamic C-11 methionine PET/CTを用いたテクスチャ解析の骨軟部腫瘍における有用性の検討, 第61回日本医学放射線学会秋季臨床大会, Oct. 2025. (Keyword) nuclear medicine
2.	HIRAOKA Junichiro, Yuta Arai, Seiji Iwamoto, 岡田直子, MATSUSHITA Tomoki, Yuka Hiroshima, Takayoshi Shinya, Masafumi Harada, Kei Daizumoto, Yoshito Kusuhara, Kimiko Sogabe and Shiroh Fujii : 後天性von Willebrand病により術後止血に難渋した1例, 第268回徳島医学会学術集会, Mar. 2024.
3.	Yuka Hiroshima, Takayoshi Shinya, Hitoshi Ikushima, Youichi Otomi, Hideki Otsuka, Chisato Tonoiso, Akiko Kubo, Takashi Kawanaka, Yasushi Takagi and Masafumi Harada : Multi-modality Imaging for the Patients with Metastatic Brain Tumors After Stereotactic Irradiation, The 82nd Annual Meeting of the Japan Radiological Society, Apr. 2023.
4.	Hiroto Kasai, Youichi Otomi, 庄野芳子, Takayoshi Shinya, MATSUSHITA Tomoki, Kohei Higashi, Ryota Mitsuhashi, Yuka Hiroshima, Hideaki Enomoto, Hideki Otsuka, Masafumi Harada and Hiroyoshi Watanabe : 芽球形質細胞様樹状細胞腫瘍のFDG PET/CT, 第137回日本医学放射線学会中国・四国地方会, Dec. 2022.
5.	Hiroaki Inoue, Souichiro Sasa, Tomohiro Inui, Mariko Aoyama, Kazumasa Okumura, Hiroyuki Sumitomo, Naoki Miyamoto, Hiroaki Toba, Yuka Hiroshima and Hiromitsu Takizawa : 当院におけるトモシンセシスガイド下マンモトーム生検の経験, 第32回日本乳癌検診学会学術総会, Nov. 2022.
6.	Hiroto Kasai, Youichi Otomi, MATSUSHITA Tomoki, Hajime Onishi, Ryota Mitsuhashi, Saya Matsuzaki, Kohei Higashi, Yuka Hiroshima, Hideaki Enomoto, Takayoshi Shinya, Hideki Otsuka and Masafumi Harada : 甲状腺様濾胞状腎細胞癌の一例, 第58回日本医学放射線学会秋季臨床大会, Sep. 2022.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

子宮体癌の糖代謝とタンパク量のテクスチャ解析に着目した次世代型ステージング法 (Project/Area Number: 26K12368 )
Search by Researcher Number (11018201)