Tokushima University / Educator and Researcher Directory --- Matsumoto, Yui

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Tokushima University ⟩ University Hospital ⟩ 先端医科医療開発研究プロジェクト ⟩
Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Neurosurgery, Psychiatry and Anesthesiology ⟩ Psychiatry ⟩
Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Neurosurgery, Psychiatry and Anesthesiology ⟩ Psychosomatic Medicine ⟩

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Research

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Yukiko Tomioka, Masahito Nakataki, Hidehiro Umehara, Tomohiro Yoshida, Hiroya Matsuda, Yui Matsumoto, Mariko Aoki, Yuri Yoshida, Yuichiroh Kamiyama, Tomohiko Nakayama, Naoki Yamada and Shusuke Numata : DNMT gene expression in peripheral leukocytes in schizophrenia and correlations with one-carbon metabolites: folate, total homocysteine, and vitamin B6., Frontiers in Psychiatry, 16, 2026. (Summary) Previous studies have identified alterations in one-carbon metabolism (OCM), including DNA methylation abnormalities, in individuals with schizophrenia. However, the precise etiology of this disorder remains unclear. In the present study, we examined variations in the expression of DNMT1 and DNMT3a-genes implicated in DNA methylation-using peripheral blood leukocytes from Japanese patients with chronic schizophrenia and healthy controls. Additionally, using our previously acquired data, we explored the association between OCM-related factors and DNMT expression levels.Expression levels of DNMT1 and DNMT3a in 215 patients with chronic schizophrenia and 210 healthy controls were quantified using real-time PCR. The Mann-Whitney U test was used to compare the differences between two independent groups. Furthermore, Spearman's correlation analysis was conducted to investigate the relationships between DNMT genes` expression levels and OCM-related metabolites (blood folate, vitamin B6, and total homocysteine).The expression levels of DNMT1 and DNMT3a in peripheral leukocytes were significantly elevated in patients with chronic schizophrenia compared with controls (p = 1.4 × 10-6 and 2.9 × 10-3, respectively). DNMT1 mRNA expression levels exhibited a weak negative correlation with folate exclusively in the aggregated cohort (N = 425) (ρ = -0.16, adjusted q = 5.0 × 10-3), and DNMT3a mRNA expression levels showed a weak negative correlation with vitamin B6 alone in the combined group (ρ = -0.12, adjusted q = 0.03).These findings suggest a potential correlation between nutritional status and elevated expression of DNMT1 and DNMT3a in schizophrenia. Our findings contribute to the understanding of the epigenetic mechanisms associated with schizophrenia and highlight the need for further investigation of the relationships among gene expression, nutritional status, and psychiatric manifestations. (Link to Publication Site) ● Publication site (DOI): 10.3389/fpsyt.2025.1715372 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41635517 ● Search Scopus @ Elsevier (PMID): 41635517 ● Search Scopus @ Elsevier (DOI): 10.3389/fpsyt.2025.1715372 (DOI: 10.3389/fpsyt.2025.1715372, PubMed: 41635517)
2.	Tomohiko Nakayama, Hidehiro Umehara, Kazuaki Mawatari, Yukiko Tomioka, Tomohiro Yoshida, Hiroya Matsuda, Yui Matsumoto, Rumiko Masuda, Toshiharu Kamishikiryo, Manabu Fuchikami, Masahito Nakataki, Akira Takahashi, Atsushi Tajima, Go Okada and Shusuke Numata : Alterations of Blood Plasma Metabolites, Including Kynurenine and Tryptophan, in Bipolar Disorder, Neuropsychiatric Disease and Treatment, 21, 1067-1073, 2025. (Keyword) kynurenine / metabolome / metabolomics / psychiatric disorder / tryptophan (Tokushima University Institutional Repository) ● Metadata: 2013758 (Link to Publication Site) ● Publication site (DOI): 10.2147/NDT.S508021 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 40406233 ● Summary page in Scopus @ Elsevier: 2-s2.0-105006852907 (Tokushima University Institutional Repository: 2013758, DOI: 10.2147/NDT.S508021, PubMed: 40406233, Elsevier: Scopus)
3.	Tomoya Takeda, Hidehiro Umehara, Yui Matsumoto, Tomohiro Yoshida, Masahito Nakataki and Shusuke Numata : Schizophrenia and cognitive dysfunction., The Journal of Medical Investigation : JMI, 71, 3.4, 205-209, 2024. (Summary) Schizophrenia is a psychiatric disorder with cognitive dysfunction as a core symptom along with positive and negative symptoms. Cognitive dysfunction in schizophrenia can be broadly classified into neurocognitive and social cognitive deficits, with these deficits significantly influencing social functioning. Therapeutic interventions aiming to enhance neurocognition and social cognition have been developed. In this review, we describe the characteristics of cognitive dysfunction in patients with schizophrenia, its relationship to social function, and intervention strategies. J. Med. Invest. 71 : 205-209, August, 2024. (Keyword) Humans / Cognitive Dysfunction / schizophrenia / Schizophrenic Psychology (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.71.205 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39462553 ● Search Scopus @ Elsevier (PMID): 39462553 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.71.205 (DOI: 10.2152/jmi.71.205, PubMed: 39462553)

Proceeding of Domestic Conference:

1.	Yui Matsumoto, 青山理央, Naoki Yamada, Masahito Nakataki and Shusuke Numata : パーキンソン病に対する脳深部刺激療法の経過中に自殺企図を起こし，うつ病や認知症との鑑別や併存について検討した1例, 第43回日本精神科診断学会, Sep. 2024.
2.	Yui Matsumoto, Masahito Nakataki, 石本良祐, 一宮俊文, 野田尚吾, 前田拓也, Tarishi Masuda, Tomohiro Yoshida, Shun Aoi, Naoki Yamada, Yukiko Tomioka, Hidehiro Umehara, 土師正太郎, Koji Fujita, Yuishin Izumi and Shusuke Numata : ADの灰白質体積と神経心理検査および髄液アミロイドβの関連性の検討, 【第42回日本認知症学会学術総会, Nov. 2023.
3.	Tomohiko Nakayama, Yui Matsumoto, Yukiko Tomioka, Naoki Yamada, Masahito Nakataki and Shusuke Numata : 長期間維持電気けいれん療法を施行している遅発緊張病の一例, 第36回日本総合病院精神医学会総会, Nov. 2023.
4.	大西将統, Yui Matsumoto, Naoki Yamada, Masahito Nakataki and Shusuke Numata : 入院治療が奏功した思春期の神経性無食欲症の1例, 第63回中国・四国精神神経学会, Nov. 2023.
5.	青山理央, Yui Matsumoto, Naoki Yamada, Masahito Nakataki and Shusuke Numata : パーキンソン病に対するDBS治療中に生じた希死念慮から自殺企図に至った一例, 第63回中国・四国精神神経学会, Nov. 2023.
6.	Yui Matsumoto, Masahito Nakataki, 石本良祐, 一宮俊文, 野田尚吾, 前田拓也, Tarishi Masuda, Tomohiro Yoshida, Shun Aoi, Naoki Yamada, Yukiko Tomioka, Hidehiro Umehara, 土師正太郎, Koji Fujita, Yuishin Izumi and Shusuke Numata : 認知症の灰白質体積と神経心理検査および髄液アミロイドβの関連性の検討, 第45回日本生物学的精神医学会年会, Nov. 2023.
7.	Tomohiko Nakayama, Hidehiro Umehara, Yukiko Tomioka, Yui Matsumoto, Tomohiro Yoshida, 上敷領俊晴, 淵上学, 岡田剛, 増田瑠見子, Kazuaki Mawatari, Masahito Nakataki, Akira Takahashi, 岡本泰昌 and Shusuke Numata : 大うつ病性障害患者における治療前後の血中代謝物濃度の変化, 第45回日本生物学的精神医学会年会, Nov. 2023.
8.	Tomohiko Nakayama, Hidehiro Umehara, Yukiko Tomioka, Yui Matsumoto, Tomohiro Yoshida, 上敷領俊晴, 淵上学, 岡田剛, 増田瑠見子, Kazuaki Mawatari, Masahito Nakataki, Akira Takahashi, 岡本泰昌 and Shusuke Numata : 双極性障害における血中代謝物の変化, 第33回日本臨床精神神経薬理学会学術集会, Sep. 2023.