徳島大学 / 教育研究者総覧 --- 塚﨑佑貴

専門分野

研究テーマ

著書・論文

学術論文(審査論文):

1.	Noriko Bando, Hirokazu Ogino, Kojin Murakami, Masami Wadatsu, Yuki Tsukazaki, Yohei Yabuki, Tatsuya Kajimoto, Rikako Matsumoto, Saki Harada, Yutaka Morita, Ryohiko Ozaki, Atsushi Mitsuhashi, Seidai Satou, Satoshi Sakaguchi, Masaki Hanibuchi and Yasuhiko Nishioka : A case of thymic carcinoma harboring an FGFR3 S249C mutation with durable disease control on lenvatinib., International Cancer Conference Journal, 15, 1, 160-165, 2025. (要約) Thymic carcinoma is a rare and aggressive malignancy with limited treatment options, resulting in a poor prognosis. Lenvatinib, a small-molecule inhibitor targeting multiple receptor tyrosine kinases, including fibroblast growth factor receptors (FGFRs), has been approved for thymic carcinoma that progresses following platinum-based chemotherapy. However, the identification of predictive biomarkers for its efficacy remains an unmet medical need. We herein present a case of 67-year-old man with advanced thymic carcinoma who was treated with carboplatin plus paclitaxel as first-line therapy. Lenvatinib, administered as second-line therapy, achieved a durable disease control that was maintained for over 20 months-exceeding the previously reported median progression-free survival. Comprehensive genomic profiling (CGP) using the FoundationOne® CDx assay identified an oncogenic FGFR3 S249C mutation. The case, together with supporting literature, suggests the potential role of FGFR3 mutations as therapeutic targets in thymic carcinoma. Furthermore, the presence of oncogenic mutations in lenvatinib-targeted genes may serve as predictive biomarkers for durable disease control. Given the limited availability of methods to detect oncogenic mutations, including FGFR3, in patients with thymic carcinoma, early implementation of CGP testing-even in the frontline setting-may be warranted in the future. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s13691-025-00836-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41589241 ● Search Scopus @ Elsevier (PMID): 41589241 ● Search Scopus @ Elsevier (DOI): 10.1007/s13691-025-00836-0 (DOI: 10.1007/s13691-025-00836-0, PubMed: 41589241)
2.	Atsushi Mitsuhashi, Kazuya Koyama, Hirokazu Ogino, Reona Matsuo, Na Nguyen Thi, Yohei Yabuki, Ryohiko Ozaki, Yuki Tsukazaki, Yutaka Morita, Aito Yoshida, Kojin Murakami, Seidai Satou, Hiroshi Kawano, Hiroshi Nokihara, Yutaka Inagaki, Tsutomu Shinohara, Masaki Hanibuchi, Hiromitsu Takizawa and Yasuhiko Nishioka : Clock pathway inhibitor overcomes tumor immune-exclusion via regulation of fibrocyte differentiation, NPJ Precision Oncology, 9, 1, 274, 2025. (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41698-025-01066-6 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-105012739596 (DOI: 10.1038/s41698-025-01066-6, Elsevier: Scopus)
3.	Keisuke Nakanishi, Hirokazu Ogino, Kojin Murakami, Yasuyo Saijo, Nobuhito Naito, Rikako Matsumoto, Yutaka Morita, Yuki Tsukazaki, Ryohiko Ozaki, Yohei Yabuki, Noriko Bando, Atsushi Mitsuhashi, Seidai Satou, Masaki Hanibuchi and Yasuhiko Nishioka : A favorable antitumor efficacy of sotorasib in a patient with KRAS G12C-mutated pulmonary large-cell neuroendocrine carcinoma., International Cancer Conference Journal, 14, 4, 374-380, 2025. (要約) The recent studies with comprehensive genomic analyses demonstrated that a certain proportion of patients with pulmonary large-cell neuroendocrine carcinoma (LCNEC) harbors some driver gene alterations. We herein present a case of 79-year-old man with Kirsten rat sarcoma virus oncogene homologue G12C-mutated pulmonary LCNEC who were treated with chemo-immunotherapy in the first-line setting. Sotorasib which was administered as second-line therapy showed a favorable therapeutic efficacy of partial response. Although sotorasib induced severe hepatobiliary disorder which forced us to terminate the treatment, the antitumor response was sustained for up to 5.6 months which was almost comparable to the therapeutic efficacy reported in pivotal clinical trials. Our case and related literature review suggest that the multiplex genetic mutation-detection assay should be considered for patients with LCNEC. Furthermore, it also suggests that biomarkers which enable us to distinguish patients who are likely to harbor driver gene alterations are required in near future. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s13691-025-00780-z (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41395550 ● Search Scopus @ Elsevier (PMID): 41395550 ● Search Scopus @ Elsevier (DOI): 10.1007/s13691-025-00780-z (DOI: 10.1007/s13691-025-00780-z, PubMed: 41395550)
4.	Kaori Nii, Hirokazu Ogino, Hiroki Bando, Yuki Yamamoto, Koji Fujita, Hiroto Yoneda, Nobuhito Naito, Atsushi Mitsuhashi, Yutaka Morita, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Seidai Satou, Masaki Hanibuchi, Yuishin Izumi and Yasuhiko Nishioka : Immune checkpoint inhibitor-associated paraneoplastic cerebellar degeneration in a case of extensive-stage small-cell lung cancer with pre-existing anti-SOX1 antibody, The Journal of Medical Investigation : JMI, 72, 1.2, 172-176, 2025. (要約) Neurological immune-related adverse events can manifest as paraneoplastic neurological syndrome (PNS), especially in patients with small-cell lung cancer (SCLC). We herein report a 73-year-old man with SCLC treated with an immune checkpoint inhibitor (ICI) combined with chemotherapy. Although the chemo-immunotherapy induced a favorable response to SCLC, he later developed acute cerebellar ataxia. He was diagnosed with paraneoplastic cerebellar degeneration associated with anti-Sry-like high mobility group box 1 (SOX1) autoantibody. The antibody was also identified in serum collected at the diagnosis of SCLC and before ICI administration, which retrospectively suggested that the patient was at risk of ICI-induced PNS. J. Med. Invest. 72 : 172-176, February, 2025. (キーワード) anti-SOX1 autoantibody / immune checkpoint inhibitors / paraneoplastic cerebellar degeneration / small-cell lung cancer (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.72.172 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 40268441 ● Summary page in Scopus @ Elsevier: 2-s2.0-105003981938 (DOI: 10.2152/jmi.72.172, PubMed: 40268441, Elsevier: Scopus)
5.	Yohei Yabuki, Atsushi Mitsuhashi, Hirokazu Ogino, Aito Yoshida, Thi Na Nguyen, Hiroto Yoneda, Ryohiko Ozaki, Yuki Tsukazaki, Yutaka Morita, Hiroshi Nokihara, Seidai Satou, Tsutomu Shinohara, Masaki Hanibuchi and Yasuhiko Nishioka : Hypoxia-inducible factor-targeting therapy augmented the sensitivity to programmed death ligand-1 blockade by enhancing interferon-γ-induced chemokines in tumor cells, International Journal of Cancer, 156, 9, 1814-1825, 2024. (要約) Immune checkpoint inhibitors (ICIs) targeting programmed death ligand-1 (PD-L1) provide clinical benefits for various advanced malignancies. However, the predictive factors that determine sensitivity to ICIs have not been fully elucidated. We focused on tumor-derived CXCL10/11 as a pivotal factor that determines the response to PD-L1 blockade by regulating T cell accumulation and tumor angiogenesis. We previously reported that CXCL10/11 was upregulated by interferon (IFN)-γ in ICI-sensitive tumor cells but not in ICI-resistant cells, including mouse Lewis lung carcinoma (LLC). In the present study, gene silencing of tumor-derived CXCL10/11 induced resistance to PD-L1 blockade in AB1-HA mesothelioma cell-bearing mice. To identify the mechanisms underlying ICI resistance, we performed a microarray analysis to compare the IFN-γ-inducible genes between ICI-sensitive AB1-HA and ICI-resistant LLC in vitro. A pathway analysis based on microarray data indicated that hypoxia-inducible factor (HIF) 1A is the key signal that inhibits CXCL10/11 expression. We revealed that the HIF1A inhibitors echinomycin (EC) and YC-1 upregulated CXCL10/11 genes induced by IFN-γ in tumor cells in vitro. In addition, combination therapy with PD-L1 blockade and EC demonstrated synergistic antitumor effects in LLC-bearing mice. Combination therapy enhanced tumor infiltration of CD8 T cells and suppressed tumor angiogenesis. The present study suggests that HIF1A signaling in tumor cells dominates ICI resistance via the downregulation of tumor-derived CXCL10/11. (キーワード) angiogenesis / CXCL10/11 / HIF1A / immune checkpoint inhibitor / interferon-γ (徳島大学機関リポジトリ) ● Metadata: 2013332 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/ijc.35301 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39686841 ● Summary page in Scopus @ Elsevier: 2-s2.0-85212305972 (徳島大学機関リポジトリ: 2013332, DOI: 10.1002/ijc.35301, PubMed: 39686841, Elsevier: Scopus)
6.	Yuki Tsukazaki, Hirokazu Ogino, Yoshio Okano, Soji Kakiuchi, Shoko Harada, Yuko Toyoda, Yugo Matsumura, Seiya Ichihara, Takeshi Imakura, Rikako Matsumoto, Ryohiko Ozaki, Ei Ogawa, Yutaka Morita, Atsushi Mitsuhashi, Yohei Yabuki, Hiroto Yoneda, Masaki Hanibuchi, Kayoko Hase, Eiji Takeuchi, Takashi Haku and Yasuhiko Nishioka : Granulocyte colony-stimulating factor has the potential to attenuate the therapeutic efficacy of chemo-immunotherapy for extensive-stage small-cell lung cancer, International Journal of Clinical Oncology, 29, 10, 1451-1460, 2024. (要約) Granulocyte colony-stimulating factor (G-CSF) has the potential to attenuate the anti-tumor immune responses of T-cells by increasing immune suppressive neutrophils and myeloid-derived suppressor cells. However, the clinical impact of G-CSF on the efficacy of immunotherapy remains unknown. This multi-center retrospective analysis evaluated the impact of G-CSF in patients with extensive-stage small-cell lung cancer (ES-SCLC) treated with chemo-immunotherapy. We analyzed 65 patients with ES-SCLC who completed four cycles of induction chemo-immunotherapy and evaluated the effects of G-CSF on progression-free survival (PFS), overall survival (OS), and a durable response to immunotherapy (defined as PFS 12 months). Fifty patients (76.9%) received 1 dose of G-CSF. The PFS of the patients with G-CSF was poorer than that of the patients without G-CSF (median PFS 8.3 vs. 4.9 months, p = 0.009). The OS of the patients with G-CSF tended to be shorter, but not statistically significant, than that of the patients without G-CSF (median OS 24.3 vs. 16.4 months, p = 0.137). In the multivariate analysis, G-CSF administration was associated with poorer PFS (hazard ratio 2.78, 95% CI 1.36-5.69, p = 0.005) and was identified as a determinant of a durable response (odds ratio 0.18, 95% CI 0.04-0.80, p = 0.024). These results were consistent with other definitions of G-CSF administration (administration of 1 dose of pegfilgrastim, or either 5 doses of filgrastim or 1 dose of pegfilgrastim). G-CSF has the potential to attenuate the efficacy of immunotherapy; therefore, the indication for G-CSF during chemo-immunotherapy should be carefully considered for ES-SCLC. (キーワード) Chemo-immunotherapy / Extensive-stage small-cell lung cancer / Granulocyte colony-stimulating factor (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10147-024-02586-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39009900 ● Summary page in Scopus @ Elsevier: 2-s2.0-85198503607 (DOI: 10.1007/s10147-024-02586-0, PubMed: 39009900, Elsevier: Scopus)
7.	Hiroyuki Kozai, Hirokazu Ogino, Atsushi Mitsuhashi, Thi Na Nguyen, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Hiroto Yoneda, Seidai Satou, Masaki Hanibuchi, Tsutomu Shinohara, Hiroshi Nokihara and Yasuhiko Nishioka : Potential of fluoropyrimidine to be an immunologically optimal partner of immune checkpoint inhibitors through inducing immunogenic cell death for thoracic malignancies., Thoracic Cancer, 15, 5, 369-378, 2024. (要約) 5-FU induced cell surface expression of CRT and ATP secretion most efficiently among the several chemotherapeutic agents. This effect was enhanced when it was combined with platinum. In the antitumor vaccination assay in vivo, we found that vaccination with dying-AB1-HA (a murine malignant mesothelioma cell line) cells treated with 5-FU, but neither PEM nor PTX, reduced the tumor growth of living-AB1-HA cells inoculated 1 week after vaccination by recruiting CD3 (キーワード) Humans / Animals / Mice / Carcinoma, Non-Small-Cell Lung / Immune Checkpoint Inhibitors / CD8-Positive T-Lymphocytes / Platinum / Immunogenic Cell Death / Lung Neoplasms / Pemetrexed / Antimetabolites / Cell Line, Tumor / Taxoids / Fluorouracil / Adenosine Triphosphate / Tumor Microenvironment (徳島大学機関リポジトリ) ● Metadata: 2012077 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/1759-7714.15200 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38146645 ● Search Scopus @ Elsevier (PMID): 38146645 ● Search Scopus @ Elsevier (DOI): 10.1111/1759-7714.15200 (徳島大学機関リポジトリ: 2012077, DOI: 10.1111/1759-7714.15200, PubMed: 38146645)
8.	Kenya Miyamoto, Hirokazu Ogino, Takumi Kakimoto, Yugo Matsumura, Keiko Haji, Atsushi Mitsuhashi, Yutaka Morita, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Hiroto Yoneda, Seidai Satou, Masaki Hanibuchi, Yoshimi Bando, Hiroshi Nokihara and Yasuhiko Nishioka : Transformation of epidermal growth factor receptor mutated lung adenocarcinoma to small-cell carcinoma long after the cessation of tyrosine kinase inhibitor treatment: A case series and literature review, Respiratory Medicine Case Reports, 51, 102076, 2024. (キーワード) Acquired resistance / Epidermal growth factor receptor / Non-small-cell lung cancer / Small-cell lung cancer transformation / Tyrosine kinase inhibitors (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.rmcr.2024.102076 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85196709618 (DOI: 10.1016/j.rmcr.2024.102076, Elsevier: Scopus)
9.	Hiroki Takahashi, Hirokazu Ogino, Hiroki Bando, Atsushi Mitsuhashi, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Hiroto Yoneda, Seidai Satou, Masaki Hanibuchi and Yasuhiko Nishioka : FoundationOne CDx detected an uncovered variant of epidermal growth factor receptor exon 19 deletion by Oncomine Dx target test in a patient with lung adenocarcinoma., Respiratory Medicine Case Reports, 45, 101893, 2023. (徳島大学機関リポジトリ) ● Metadata: 2012094 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.rmcr.2023.101893 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37485237 ● Search Scopus @ Elsevier (PMID): 37485237 ● Search Scopus @ Elsevier (DOI): 10.1016/j.rmcr.2023.101893 (徳島大学機関リポジトリ: 2012094, DOI: 10.1016/j.rmcr.2023.101893, PubMed: 37485237)

国際会議:

1.	Yuki Tsukazaki, Hirokazu Ogino, Yoshio Okano, Soji Kakiuchi, Shoko Harada, Yuko Toyoda, Yugo Matsumura, Seiya Ichihara, Takeshi Imakura, Rikako Matsumoto, Ryohiko Ozaki, Ei Ogawa, Yutaka Morita, Atsushi Mitsuhashi, Yohei Yabuki, Hiroto Yoneda, Masaki Hanibuchi, Kayoko Hase, Eiji Takeuchi, Takashi Haku and Yasuhiko Nishioka : The Conflicting Impacts of G-CSF on the Therapeutic Efficacy of Chemoimmunotherapy for Extensive Stage Small Cell Lung Cancer, 2024 World Conference on Lung Cancer, San Diego, Sep. 2024.
2.	Hirokazu Ogino, Na Thi Nguyen, Hiroyuki Kozai, Atsushi Mitsuhashi, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Hiroshi Nokihara, Masaki Hanibuchi and Yasuhiko Nishioka : The potential of fluoropyrimidine to be an immunologically optimal partner of immunotherapy for thoracic malignancies, 2024 World Conference on Lung Cancer, San Diego, Sep. 2024.

国内講演発表:

1.	宮本憲哉, 山下雄也, 土師恵子, 塚﨑佑貴, 香川耕造, 宮本直輝, 荻野広和, 河野弘, 佐藤正大, 埴淵昌毅, 鳥羽博明, 滝沢宏光, 西岡安彦 : 気管支鏡検査で診断し得た肺原発高悪性度胎児型腺癌の一例, 第34回日本呼吸器内視鏡学会中国四国支部会, 2025年12月.
2.	松本利加子, 荻野広和, 山下雄也, 梶本達也, 森田優, 三橋惇志, 塚﨑佑貴, 佐藤正大, 埴淵昌毅, 西岡安彦 : 進展型小細胞肺癌に対する化学免疫療法の肝転移制御効果に関する後方視的検討, 第133回日本内科学会四国地方会, 2025年11月.
3.	三橋惇志, 荻野広和, 塚﨑佑貴, 森田優, 軒原浩, 埴淵昌毅, 西岡安彦 : 細胞外基質成分解析による免疫チェックポイント阻害薬耐性機序の解明, 第66回日本肺癌学会学術集会, 2025年11月.
4.	荻野広和, 松本利加子, 塚﨑佑貴, 森田優, 梶本達也, 三橋惇志, 埴淵昌毅, 西岡安彦 : 肺癌に対するアムルビシン投与に伴う薬剤性肺障害の発症に関連するリスク因子について, 第66回日本肺癌学会学術集会, 2025年11月.
5.	森田優, Bayarmaa Agarzandan, 三橋惇志, 吉田碧人, 荻野広和, 塚﨑佑貴, 松本利加子, 軒原浩, 埴淵昌毅, 西岡安彦 : 胸膜中皮腫に対する時計遺伝子阻害薬の血管新生制御を介した治療効果の検討, 第66回日本肺癌学会学術集会., 2025年11月.
6.	松本利加子, 荻野広和, 塚﨑佑貴, 森田優, 梶本達也, 三橋惇志, 埴淵昌毅, 西岡安彦 : 肺癌に対するアムルビシンによる薬剤性肺障害発症リスクに関する後方視的検討, 第63回日本癌治療学会学術集会, 2025年10月.
7.	Agarzandan Bayarmaa, 三橋惇志, 荻野広和, 吉田碧人, 塚﨑佑貴, 尾崎領彦, 森田優, 埴淵昌毅, 西岡安彦 : 時計遺伝子阻害薬による胸膜中皮腫に対する血管新生抑制作用の検討, 第84回日本癌学会学術総会, 2025年9月.
8.	三橋惇志, 吉田碧人, 荻野広和, 尾崎領彦, 塚﨑佑貴, 森田優, Agarzandan Bayarmaa, 松本利加子, 軒原浩, 埴淵昌毅, 西岡安彦 : 細胞外基質成分解析によるがん免疫排除誘導機序の探索, 第84回日本癌学会学術総会, 2025年9月.
9.	三橋惇志, 吉田碧人, 荻野広和, 尾崎領彦, 塚﨑佑貴, 西岡安彦 : 免疫排除を構築する細胞外基質成分同定による免疫チェックポイント阻害薬耐性機序の解析, 第29回日本がん分子標的治療学会学術集会, 2025年7月.
10.	Agarzandan Bayarmaa, Atsushi Mitsuhashi, Hirokazu Ogino, Yoshida Aito, Yuki Tsukazaki, Ryohiko Ozaki, Yutaka Morita, Masaki Hanibuchi and Yasuhiko Nishioka : The anti-angiogenic effects of clock gene inhibitors in malignant pleural mesothelioma, the 34th Annual Meeting and General Meeting of the Japanese Association for Cancer Metastasis, Jun. 2025.
11.	松本利加子, 荻野広和, 森田優, 塚﨑佑貴, 尾崎領彦, 三橋惇志, 佐藤正大, 埴淵昌毅, 西岡安彦 : 進展型小細胞肺癌に対する化学免疫療法の遠隔転移制御効果に関する後方視的検討, 第65回日本呼吸器学会学術講演会, 2025年4月.
12.	松本利加子, 荻野広和, 塚﨑佑貴, 森田優, 尾崎領彦, 三橋惇志, 埴淵昌毅, 西岡安彦 : 進展型小細胞肺癌における化学免疫療法の遠隔転移制御効果に関する後方視的検討, 第22回日本臨床腫瘍学会学術集会, 2025年3月.
13.	尾崎領彦, 荻野広和, 森田優, 松本利加子, 塚﨑佑貴, 三橋惇志, 軒原浩, 西岡安彦 : 進展型小細胞肺癌における二次化学療法を妨げる因子の検討, 第22回日本臨床腫瘍学会学術集会, 2025年3月.
14.	塚﨑佑貴, 荻野広和, 岡野義夫, 柿内聡司, 豊田優子, 松本利加子, 尾崎領彦, 森田優, 三橋惇志, 矢葺洋平, 埴淵昌毅, 長谷加容子, 竹内栄治, 葉久貴司, 西岡安彦 : G-CSFが進展型小細胞肺癌における化学免疫療法の治療効果に及ぼす影響を検討した多施設共同後方視的解析, 第65回日本肺癌学会学術集会, 2024年11月.
15.	矢葺洋平, 三橋惇志, 荻野広和, 尾崎領彦, 塚﨑佑貴, 埴淵昌毅, 西岡安彦 : IFN-γ反応性ケモカイン産生制御機序の解明と新規複合がん免疫療法への応用, 第65回日本肺癌学会学術集会, 2024年11月.
16.	三橋惇志, 荻野広和, 矢葺洋平, 尾崎領彦, 塚﨑佑貴, 埴淵昌毅, 軒原浩, 西岡安彦 : Fibrocyte 分化制御による免疫排除克服と新規複合がん免疫療法への展開, 第65回日本肺癌学会学術集会, 2024年10月.
17.	塚﨑佑貴, 荻野広和, 岡野義夫, 柿内聡司, 豊田優子, 松本利加子, 尾崎領彦, 森田優, 三橋惇志, 矢葺洋平, 埴淵昌毅, 長谷加容子, 竹内栄治, 葉久貴司, 西岡安彦 : G-CSF が進展型小細胞肺癌に対する化学免疫療法の治療効果に及ぼす影響に関する解析, 第62回日本癌治療学会学術集会, 2024年10月.
18.	三橋惇志, 小山壱也, 荻野広和, 矢葺洋平, 尾崎領彦, 塚﨑佑貴, 森田優, 吉田碧人, 軒原浩, 埴淵昌毅, 西岡安彦 : Fibrocyte 制御によるがん免疫排除克服に向けた治療戦略, 第83回日本癌学会学術総会, 2024年9月.
19.	近藤圭大, 村上行人, 坂東弘基, 塚﨑佑貴, 荻野広和, 松本利加子, 森田優, 三橋惇志, 尾崎領彦, 矢葺洋平, 佐藤正大, 埴淵昌毅, 岡野義夫, 柿内聡司, 豊田優子, 長谷加容子, 竹内栄治, 葉久貴司, 西岡安彦 : 進展型小細胞肺癌において顆粒球コロニー刺激因子が化学免疫療法の治療効果に及ぼす影響, 第269回徳島医学会学術集会, 2024年7月.
20.	伊藤一輝, 村上行人, 坂東弘基, 山本浩生, 塚﨑佑貴, 内藤伸仁, 荻野広和, 佐藤正大, 埴淵昌毅, 西岡安彦 : EGFR L858R 変異陽性肺腺癌に対して CBDCA+nab-PTX+Atezolizumab が pseudoprogression を伴って著効した一例, 第70回日本呼吸器学会中国・四国地方会, 2024年7月.
21.	塚﨑佑貴, 飛梅亮, 三橋惇志, 尾崎領彦, 矢葺洋平, 米田浩人, 荻野広和, 埴淵昌毅, 小川博久, 滝沢宏光, 西岡安彦 : 線維細胞の腫瘍内浸潤およびそれを誘導する走化因子が非小細胞肺癌の予後に及ぼす影響についての解析, 第64回日本呼吸器学会学術講演会, 2024年4月.
22.	荻野広和, Nguyen Thi Na, 香西博之, 三橋惇志, 塚﨑佑貴, 矢葺洋平, 尾崎領彦, 埴淵昌毅, 西岡安彦 : 胸部腫瘍に対して免疫チェックポイント阻害薬と併用すべき至適抗がん剤の同定を目指した免疫学的解析, 第64回日本呼吸器学会学術講演会, 2024年4月.
23.	Yuki Tsukazaki, Hirokazu Ogino, Yoshio Okano, Soji Kakiuchi, Shoko Harada, Yugo Matumura, Seiya Ichihara, Takeshi Imakura, Ryohiko Ozaki, Ei Ogawa, Yutaka Morita, Atsushi Mitsuhashi, Yohei Yabuki, Hiroto Yoneda, Masaki Hanibuchi, Yuko Toyoda, Kayoko Hase, Eiji Takeuchi, Takashi Haku and Yasuhiko Nishioka : The impacts of G-CSF on the therapeutic efficacy of chemo-immunotherapy for extensive-stage small cell lung cancer., 2024 the Japanese Society of Medical Oncology Annual Meeting (JSMO2024), Feb. 2024.
24.	Hirokazu Ogino, Nguyen Na Thi, Hiroyuki Kozai, Atsushi Mitsuhashi, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Hiroshi Nokihara, Masaki Hanibuchi and Yasuhiko Nishioka : Fluoropyrimidine has a potential to be an immunologically optimal partner ofimmunotherapy for thoracic malignancies., 2024 the Japanese Society of Medical Oncology Annual Meeting (JSMO2024), Feb. 2024.
25.	塚﨑佑貴, 飛梅亮, 三橋惇志, 尾崎領彦, 矢葺洋平, 米田浩人, 荻野広和, 埴淵昌毅, 小川博久, 滝沢宏光, 西岡安彦 : 非小細胞肺癌症例における腫瘍浸潤線維細胞の走化因子と疾患予後との関連性についての解析, 第64回日本肺癌学会学術集会, 2023年11月.
26.	荻野広和, 香西博之, 三橋惇志, 塚﨑佑貴, 矢葺洋平, 尾崎領彦, 米田浩人, 埴淵昌毅, 軒原浩, 西岡安彦 : フッ化ピリミジンは胸部腫瘍の免疫原性細胞死を誘導し免疫チェックポイント阻害薬の至適併用薬となり得る, 第64回日本肺癌学会学術集会, 2023年11月.
27.	尾崎領彦, 軒原浩, 塚﨑佑貴, 矢葺洋平, 三橋惇志, 米田浩人, 荻野広和, 西岡安彦 : 進展型小細胞肺癌において2次治療が受けられない患者の臨床的背景の検討, 第64回日本肺癌学会学術集会, 2023年11月.
28.	矢葺洋平, 三橋惇志, 荻野広和, Na T. Nguyen, 米田浩人, 尾崎領彦, 塚﨑佑貴, 埴淵昌毅, 軒原浩, 西岡安彦 : HIF1A 阻害による腫瘍細胞由来 CXCL10/11 制御を介した抗 PDL1 抗体への耐性克服, 第82回日本癌学会学術総会, 2023年9月.
29.	塚﨑佑貴, 三橋惇志, 尾崎領彦, 矢葺洋平, 米田浩人, 荻野広和, 西岡安彦 : 肺癌における腫瘍浸潤線維細胞の走化因子とその疾患予後に及ぼす影響についての解析, 第27回日本がん分子標的治療学会学術集会, 2023年6月.

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特任助教 : 塚﨑佑貴

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

特任助教 : 塚﨑 佑貴

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学術論文(審査論文):

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

特任助教 : 塚﨑佑貴