徳島大学 / 教育研究者総覧 --- 松田拓

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徳島大学 ⟩ 大学院医歯薬学研究部 ⟩ 医学域 ⟩ 特定研究部門 ⟩ 教育支援系 ⟩ 医学教育支援 ⟩

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著書・論文

学術論文(審査論文):

1.	森垣龍馬, 松田拓, 三宅一央, 髙木康志 : 若手に知ってほしい不随意運動症基礎研究の魅力, 機能的脳神経外科, Vol.63, 26-31, 2025年.
2.	Hiroshi Ohmae, Taku Matsuda, Maki Fujimoto, Yuka Nakanowatari, Megumi Yamada, Nori Sato, Kimiko Umemura, Ryoma Morigaki, Tetsuya Matsuura and Yasushi Takagi : Safety and Selection Criteria of Single-joint Hybrid Assistive Limb for Upper Limb Paralysis After Stroke: A Phase I Trial., Neurologia Medico-Chirurgica, Vol.65, No.1, 15-21, 2024. (要約) Robotic rehabilitation is a high-intensity intervention for upper limb paralysis after a stroke. This study explored the safety and feasibility of using a single-joint hybrid assistive limb (HAL-SJ) exoskeletal device for upper limb paralysis in patients with acute stroke. In total, 11 patients with stroke (6 with moderate paralysis and 5 with severe paralysis) were enrolled between October 2021 and October 2023 in a stroke care unit. The patients underwent HAL training 3 times a week for 6 sessions. No serious adverse events related to HAL-SJ occurred, and participants demonstrated significant improvements in the Fugl-Meyer Assessment Upper Extremity (FMA-UE) and Action Research Arm Test (ARAT) (pre- vs. post-intervention; p < 0.05). The minimal clinically important difference (MCID) for FMA-UE was surpassed in 5 patients (83.3%) with moderate paralysis and 2 (40.0%) with severe paralysis. Regarding ARAT, 4 patients (66.7%) with moderate paralysis exceeded the MCID, whereas none (0.0%) with severe paralysis did. These findings suggest that HAL-SJ is both safe and feasible, particularly for individuals with moderate paralysis. (キーワード) Humans / Male / Female / Middle Aged / Stroke Rehabilitation / Aged / Paralysis / Upper Extremity / Stroke / Exoskeleton Device / Adult / Patient Selection / Feasibility Studies (出版サイトへのリンク) ● Publication site (DOI): 10.2176/jns-nmc.2024-0137 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39581619 ● Search Scopus @ Elsevier (PMID): 39581619 ● Search Scopus @ Elsevier (DOI): 10.2176/jns-nmc.2024-0137 (DOI: 10.2176/jns-nmc.2024-0137, PubMed: 39581619)
3.	Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Hiroshi Omae, Kaito Suzuki, Taku Matsuda, Hiroshi Koyama, Emi Ishitani, Yuishin Izumi and Yasushi Takagi : Striking Efficacy of Pallidal Deep Brain Stimulation in a Patient with Predominant Abductor Laryngeal Dystonia: A Case Report., Movement Disorders Clinical Practice, Vol.11, No.11, 1462-1464, 2024. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/mdc3.14189 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39132907 ● Search Scopus @ Elsevier (PMID): 39132907 ● Search Scopus @ Elsevier (DOI): 10.1002/mdc3.14189 (DOI: 10.1002/mdc3.14189, PubMed: 39132907)
4.	Hiroshi Kagusa, Yamaguchi Izumi, Shono Kenji, Mizobuchi Yoshifumi, Shikata Eiji, Taku Matsuda, Takeshi Miyamoto, Keijiro Hara, Kitazato T Keiko, Yoshihiro Uto, Kanematsu Yasuhisa and Yasushi Takagi : Differences in amyloid-β and tau/p-tau deposition in blood-injected mouse brains using micro-syringe to mimic traumatic brain microhemorrhages, Journal of Chemical Neuroanatomy, Vol.130, 102258, 2023. (要約) Cerebral microbleeds (CMBs) due to traumatic brain injuries (TBI) have been shown to lead to cognitive decline and impairment. CMBs caused by TBI may be associated with pathophysiological mechanisms involving inflammation and the accumulation of amyloid-β (Aβ), tau, and phosphorylated tau (p-tau), contributing to cognitive abnormalities. However, their relationships remain unclear. To test our hypothesis that Aβ, tau, and p-tau are accumulated and regulated separately in mice with injuries imitating CMBs from TBI, we studied. Seven-week-old C57BL/6 male mice were injected with 15 μL of heparinized autologous blood or saline by micro-syringe into the front lobe. Expression profiles and regulation of Aβ, tau, and p-tau were assessed immunohistochemically over time. On day 7 after blood injection, Iba-1 and S100B cells in damaged cortex adjacent to the injection site were higher than saline injection group and non-injected sham. On days 3-14, Aβ deposition were gradually increased but normalized by day 28. In contrast, tau/p-tau deposition gradually increased during days 14-28 and dispersed along the corticomedullary junction adjacent to hem deposits, indicating different expression profiles from Aβ. Deposits of Aβ, but not tau/p-tau, were phagocytosed by CD163 macrophages increased by Gc-protein macrophage-activating factor during days 7-28, suggesting different mechanisms of deposition and regulation between Aβ and tau/p-tau. Deposition and regulation differ between Aβ and tau/p-tau in mice with injuries mimicking CMBs from TBI. Further clarification of relationships between the pathologies of cognitive impairment and their neurodegenerative consequences is needed. (キーワード) Amyloid-β / Cognitive impairment / Tauopathy / Traumatic cerebral microbleed (徳島大学機関リポジトリ) ● Metadata: 2012257 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jchemneu.2023.102258 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36925083 ● Search Scopus @ Elsevier (PMID): 36925083 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jchemneu.2023.102258 (徳島大学機関リポジトリ: 2012257, DOI: 10.1016/j.jchemneu.2023.102258, PubMed: 36925083)
5.	大前博司, 森垣龍馬, 三宅一央, 松田拓, 髙木康志 : 高齢パーキンソン病患者に対する視床下核脳深部刺激療法による変化の検討, 日本老年脳神経外科学会誌, Vol.36, 43-48, 2023年.

国際会議:

1.	Taku Matsuda, Ryoma Morigaki, Hiroaki Hayasawa, Hiroshi Koyama, Teruo Oda, Kazuhisa Miyake and Yasushi Takagi : Striatal parvalbumin interneurons, not cholinergic interneurons, are activated in a mouse model of cerebellar dystonia, NEURO2024, Fukuoka, Jul. 2024.

国内講演発表:

1.	森垣龍馬, 三宅一央, 松田拓, 藤川丈自, 篠原恵介, 髙木康志 : 首下がり全身性ジストニアの一例, 第7回中国四国機能外科懇話会, 2025年3月.
2.	三宅一央, 松田拓, 森垣龍馬, 髙木康志 : 手術中の既存電極の変化に関して，2症例の検討, 第64回日本定位・機能神経外科学会, 2025年2月.
3.	松田拓, 森垣龍馬, 三宅一央, 髙木康志 : 小脳性ジストニアモデルマウスの線条体ではパルブアルブミン陽性介在ニューロンの活性化がみられる, 第64回日本定位・機能神経外科学会, 2025年2月.
4.	森垣龍馬, 松田拓, 篠原恵介, 藤川丈自, 三宅一央, 髙木康志 : ジストニアにおける線条体ストリオソーム構造と小脳の異常, 第64回日本定位・機能神経外科学会, 2025年2月.
5.	森垣龍馬, 三宅一央, 松田拓, 宮本亮介, 大前博司, 和泉唯信, 髙木康志 : ジストニアに対する両側淡蒼球刺激術における最近の刺激方法, 第64回日本定位・機能神経外科学会, 2025年2月.
6.	大前博司, 藤本真希, 松田拓, 森垣龍馬, 髙木康志 : 急性期脳卒中患者に対するSinglejoint type of Hybrid Assistive Limbの効果 ―ケースシリーズ研究―, 第58回日本作業療法学会, 2024年11月.
7.	松田拓, 原慶次郎, 鈴木海斗, 三宅一央, 髙木康志 : 外傷後の高次脳機能障害の精査で脳脊髄液漏出症と診断された一例, 日本脳神経外科学会第83回学術総会, 2024年10月.
8.	松田拓, 原慶次郎, 鈴木海斗, 三宅一央, 髙木康志 : 外傷後の高次脳機能障害の精査で脳脊髄液漏出症と診断された一例, 23回舞連カンファレンス, 2024年8月.
9.	森垣龍馬, 三宅一央, 松田拓, 髙木康志 : 赤核振戦に伴う痛みに対して著効した脳深部刺激療法の一例, 第6回中国四国機能神経外科懇話会, 2024年3月.
10.	森垣龍馬, 三宅一央, 宮本亮介, 大前博司, 松田拓, 小山広士, 和泉唯信, 髙木康志 : GPi-DBSが著効した外転型痙攣性発声障害の一例, 第63回日本定位機能外科学会, 2024年2月.
11.	松田拓, 鹿草宏, 佐藤紀, 梅山公子, 松浦哲也, 兼松康久, 髙木康志 : HALによる歩行訓練で歩容の改善を得られた深部感覚障害による歩行障害の一例, 2023年12月.

その他・研究会:

1.	森垣龍馬, 三宅一央, 松田拓, 小山広士, 髙木康志 : 最近のジストニア手術症例の検討, 第50回徳島脳神経外科談話会, 2024年12月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

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