徳島大学 / 教育研究者総覧 --- 篠原侑成

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徳島大学 ⟩ 大学院社会産業理工学研究部 ⟩ 生物資源産業学域 ⟩ 応用生命系 ⟩ 応用生命科学分野 ⟩
徳島大学 ⟩ 生物資源産業学部 ⟩ 生物資源産業学科 ⟩ 応用生命コース ⟩

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研究活動

専門分野

○	生物有機化学 (Bioorganic Chemistry), 創薬化学 (Medicinal Chemistry), 薬物送達学 (Drug Delivery Science)

研究テーマ

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著書・論文

学術論文(審査論文):

1.	Tsuyoshi Takara, Rei Takara, Aya Kobayashi, Hina Shirakata, Shinobu Ambai, Yusei Shinohara and Yoshihiro Uto : Serum-Derived Macrophage-Activating Factor ExhibitsAnti-Tumor Activity via M2-to-M1 Macrophage Reprogramming, International Journal of Translational Medicine, Vol.4, 439-449, 2024. (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ijtm4030029 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.3390/ijtm4030029 (DOI: 10.3390/ijtm4030029)
2.	Yusei Shinohara, Yuki Komiya, Kashin morimoto, Yoshio Endo, Minoru Terashima, Takeshi Suzuki, Takahisa Takino, Itasu Ninomiya, Hisatsugu Yamada and Yoshihiro Uto : Development of UTX-143, a Selective Sodium-hydrogen Exchange Subtype 5 Inhibitor, using Amiloride as a Lead Compound, Bioorganic & Medicinal Chemistry, Vol.99, 117603, 2024. (要約) NHE5, an isoform of the Na/H exchanger (NHE) protein, is an ion-transporting membrane protein that regulates intracellular pH and is highly expressed in colorectal adenocarcinoma. Therefore, we hypothesized that NHE5 inhibitors can be used as anticancer drugs. However, because NHE1 is ubiquitously expressed in all cells, it is extremely important to demonstrate its selective inhibitory activity against NHE5. We used amiloride, an NHE non-selective inhibitor, as a lead compound and created UTX-143, which has NHE5-selective inhibitory activity, using a structure-activity relationship approach. UTX-143 showed selective cytotoxic effects on cancer cells and reduced the migratory and invasive abilities of cancer cells. These results suggest a new concept wherein drugs exhibit cancer-specific cytotoxic effects through selective inhibition of NHE5 and the possibility of UTX-143 as a lead NHE5-selective inhibitor. (キーワード) Amiloride / Sodium / Sodium-Hydrogen Exchangers / Membrane Proteins / Hydrogen / Hydrogen-Ion Concentration (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.bmc.2024.117603 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38246115 ● Summary page in Scopus @ Elsevier: 2-s2.0-85183558460 (DOI: 10.1016/j.bmc.2024.117603, PubMed: 38246115, Elsevier: Scopus)
3.	Hirari Yamahana, Yusei Shinohara, Yoshio Endo, Tohru Obata, Hisatsugu Yamada and Yoshihiro Uto : Enhancing Effect of Novel Schiff Base Derivatives, UTX-134 and UTX-135, on 5-Aminolevulinic Acid-based Photodynamic Therapy, ALA-Porphyrin Science, Vol.10, No.1, 1-14, 2021. (キーワード) 5-aminolevulinic acid / protoporphyrin IX / photodynamic therapy / shiff-base
4.	Yusei Shinohara, Yoshio Endo, Chiaki Abe, Ikkyu Shiba, Masahiro Ishizuka, Tohru Tanaka, Yutaka Yonemura, Shun-Ichiro Ogura, Masahide Tominaga, Hisatsugu Yamada and Yoshihiro Uto : Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy, Photodiagnosis and Photodynamic Therapy, Vol.20, 182-188, 2017. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.pdpdt.2017.10.014 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85032287431 (DOI: 10.1016/j.pdpdt.2017.10.014, Elsevier: Scopus)