徳島大学 / 教育研究者総覧 --- 篠原侑成

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徳島大学 ⟩ 大学院社会産業理工学研究部 ⟩ 生物資源産業学域 ⟩ 応用生命系 ⟩ 応用生命科学分野 ⟩
徳島大学 ⟩ 生物資源産業学部 ⟩ 生物資源産業学科 ⟩ 応用生命コース ⟩

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研究活動

専門分野

○	生物有機化学 (Bioorganic Chemistry), 創薬化学 (Medicinal Chemistry), 薬物送達学 (Drug Delivery Science)

研究テーマ

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著書・論文

学術論文(審査論文):

1.	Tsuyoshi Takara, Rei Takara, Aya Kobayashi, Hina Shirakata, Shinobu Ambai, Yusei Shinohara and Yoshihiro Uto : Serum-Derived Macrophage-Activating Factor ExhibitsAnti-Tumor Activity via M2-to-M1 Macrophage Reprogramming, International Journal of Translational Medicine, 4, 439-449, 2024. (徳島大学機関リポジトリ) ● Metadata: 2012829 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ijtm4030029 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.3390/ijtm4030029 (徳島大学機関リポジトリ: 2012829, DOI: 10.3390/ijtm4030029)
2.	Yusei Shinohara, Yuki Komiya, Kashin morimoto, Yoshio Endo, Minoru Terashima, Takeshi Suzuki, Takahisa Takino, Itasu Ninomiya, Hisatsugu Yamada and Yoshihiro Uto : Development of UTX-143, a Selective Sodium-hydrogen Exchange Subtype 5 Inhibitor, using Amiloride as a Lead Compound, Bioorganic & Medicinal Chemistry, 99, 117603, 2024. (要約) NHE5, an isoform of the Na/H exchanger (NHE) protein, is an ion-transporting membrane protein that regulates intracellular pH and is highly expressed in colorectal adenocarcinoma. Therefore, we hypothesized that NHE5 inhibitors can be used as anticancer drugs. However, because NHE1 is ubiquitously expressed in all cells, it is extremely important to demonstrate its selective inhibitory activity against NHE5. We used amiloride, an NHE non-selective inhibitor, as a lead compound and created UTX-143, which has NHE5-selective inhibitory activity, using a structure-activity relationship approach. UTX-143 showed selective cytotoxic effects on cancer cells and reduced the migratory and invasive abilities of cancer cells. These results suggest a new concept wherein drugs exhibit cancer-specific cytotoxic effects through selective inhibition of NHE5 and the possibility of UTX-143 as a lead NHE5-selective inhibitor. (キーワード) Amiloride / Sodium / Sodium-Hydrogen Exchangers / Membrane Proteins / Hydrogen / Hydrogen-Ion Concentration (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.bmc.2024.117603 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38246115 ● Summary page in Scopus @ Elsevier: 2-s2.0-85183558460 (DOI: 10.1016/j.bmc.2024.117603, PubMed: 38246115, Elsevier: Scopus)
3.	Hirari Yamahana, Yusei Shinohara, Yoshio Endo, Tohru Obata, Hisatsugu Yamada and Yoshihiro Uto : Enhancing Effect of Novel Schiff Base Derivatives, UTX-134 and UTX-135, on 5-Aminolevulinic Acid-based Photodynamic Therapy, ALA-Porphyrin Science, 10, 1, 1-14, 2021. (キーワード) 5-aminolevulinic acid / protoporphyrin IX / photodynamic therapy / shiff-base
4.	Yusei Shinohara, Yoshio Endo, Chiaki Abe, Ikkyu Shiba, Masahiro Ishizuka, Tohru Tanaka, Yutaka Yonemura, Syunichiro Ogura, Masahide Tominaga, Hisatsugu Yamada and Yoshihiro Uto : Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy., Photodiagnosis and Photodynamic Therapy, 20, 182-188, 2017. (要約) 5-Aminolevulinic acid (ALA), a precursor of protoporphyrin IX (PpIX), is now widely used for photodynamic diagnosis (ALA-PDD) and photodynamic therapy (ALA-PDT) of various cancers. Recently, we found that treatment of cancer cells with the Schiff base derivative TX-816 along with ALA could significantly increase the efficacy of ALA-PDT. This enhancing effect of TX-816 on ALA-PDT is attributed to 3,5-dichlorosalicylaldehyde (DCSA), a molecule produced by the degradation of TX-816. Similar to TX-816, DCSA significantly enhances the effect of ALA-PDT. Furthermore, DCSA could restore the sensitivity of cancer cells that acquired resistance to ALA-PDT. These results indicate that DCSA, as well as TX-816, is a potent lead compound for the development of an ALA-PDT sensitizer. TX-816 might be a useful compound for designing prodrug-type ALA-PDT enhancers. (キーワード) 5-Aminolevulinic acid / Photodynamic therapy / Protoporphyrin IX / Schiff base (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.pdpdt.2017.10.014 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29056554 ● Summary page in Scopus @ Elsevier: 2-s2.0-85032287431 (DOI: 10.1016/j.pdpdt.2017.10.014, PubMed: 29056554, Elsevier: Scopus)

国内講演発表:

1.	宇都義浩, 篠原侑成, 小林彩, 藤井理, 野田祥汰, 仁木真理子, 久保宜明, 稲垣正 : リポソーム化ビタミンCとnanoPDS化ビタミンCの皮膚浸透性および皮膚細胞に対する機能性の比較評価, 第25回抗加齢医学会総会, 2025年6月.
2.	篠原侑成, 森本華真, 小宮悠生, 二宮致, 遠藤良夫, 滝野隆久, 山田久嗣, 宇都義浩 : In silico 創薬によるNa+/H+交換輸送体5(NHE5)に対する選択的阻害剤の創製, 日本薬学会第145年会, 2025年3月.
3.	𠮷野颯真, 藤井理, 田坂徹, 仁木真理子, 宇都義浩, 篠原侑成 : アトピー性⽪膚炎様モデルマウスに対する瞬芽ブドウ種⼦成分の改善効果, 第12回日本化学会中国四国支部大会岡山大会, 2024年11月.
4.	高橋孝輔, 篠原侑成, 宇都義浩, 山田久嗣 : 磁気共鳴イメージングのためのホスホセリンポリマープローブの合成と機能評価, 第12回日本化学会中国四国支部大会岡山大会, 2024年11月.
5.	大山朋晃, 田口ひかり, 篠原侑成, 宇都義浩, 山田久嗣 : 多重共鳴拡散NMR法によるスルホベタインポリマーの⽣体内粒⼦径解析, 第12回日本化学会中国四国支部大会岡山大会, 2024年11月.
6.	篠原侑成, 藤井理, 田坂徹, 𠮷野颯真, 野田祥汰, 小林彩, 中山清美, 佐藤宏晶, 宇都義浩 : リポソーム化糖混合物による間質性肺炎の炎症抑制効果, 第76回日本生物工学会大会, 2024年9月.
7.	篠原侑成, 芝一休, 山田久嗣, 遠藤良夫, 石塚昌宏, 宇都義浩 : 5-アミノレブリン酸を用いた光線力学治療ALA-PDTに対する増感剤TX-816の創製, 日本化学会第98春季年会, 2018年3月.