徳島大学 / 教育研究者総覧 --- 松田宙也

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徳島大学 ⟩ 病院 ⟩ 診療科 ⟩ 脳·神経·精神科 ⟩ 精神科神経科 ⟩
徳島大学 ⟩ 病院 ⟩ 診療科 ⟩ 脳·神経·精神科 ⟩ 心身症科 ⟩

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研究テーマ

著書・論文

学術論文(審査論文):

1.	Yukiko Tomioka, Masahito Nakataki, Hidehiro Umehara, Tomohiro Yoshida, Hiroya Matsuda, Yui Matsumoto, Mariko Aoki, Yuri Yoshida, Yuichiroh Kamiyama, Tomohiko Nakayama, Naoki Yamada and Shusuke Numata : DNMT gene expression in peripheral leukocytes in schizophrenia and correlations with one-carbon metabolites: folate, total homocysteine, and vitamin B6., Frontiers in Psychiatry, 16, 2026. (要約) Previous studies have identified alterations in one-carbon metabolism (OCM), including DNA methylation abnormalities, in individuals with schizophrenia. However, the precise etiology of this disorder remains unclear. In the present study, we examined variations in the expression of DNMT1 and DNMT3a-genes implicated in DNA methylation-using peripheral blood leukocytes from Japanese patients with chronic schizophrenia and healthy controls. Additionally, using our previously acquired data, we explored the association between OCM-related factors and DNMT expression levels.Expression levels of DNMT1 and DNMT3a in 215 patients with chronic schizophrenia and 210 healthy controls were quantified using real-time PCR. The Mann-Whitney U test was used to compare the differences between two independent groups. Furthermore, Spearman's correlation analysis was conducted to investigate the relationships between DNMT genes` expression levels and OCM-related metabolites (blood folate, vitamin B6, and total homocysteine).The expression levels of DNMT1 and DNMT3a in peripheral leukocytes were significantly elevated in patients with chronic schizophrenia compared with controls (p = 1.4 × 10-6 and 2.9 × 10-3, respectively). DNMT1 mRNA expression levels exhibited a weak negative correlation with folate exclusively in the aggregated cohort (N = 425) (ρ = -0.16, adjusted q = 5.0 × 10-3), and DNMT3a mRNA expression levels showed a weak negative correlation with vitamin B6 alone in the combined group (ρ = -0.12, adjusted q = 0.03).These findings suggest a potential correlation between nutritional status and elevated expression of DNMT1 and DNMT3a in schizophrenia. Our findings contribute to the understanding of the epigenetic mechanisms associated with schizophrenia and highlight the need for further investigation of the relationships among gene expression, nutritional status, and psychiatric manifestations. (出版サイトへのリンク) ● Publication site (DOI): 10.3389/fpsyt.2025.1715372 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41635517 ● Search Scopus @ Elsevier (PMID): 41635517 ● Search Scopus @ Elsevier (DOI): 10.3389/fpsyt.2025.1715372 (DOI: 10.3389/fpsyt.2025.1715372, PubMed: 41635517)
2.	Tomohiko Nakayama, Hidehiro Umehara, Kazuaki Mawatari, Yukiko Tomioka, Tomohiro Yoshida, Hiroya Matsuda, Yui Matsumoto, Masuda Rumiko, Kamishikiryo Toshiharu, Fuchikami Manabu, Masahito Nakataki, Akira Takahashi, Atsushi Tajima, Okada Go and Shusuke Numata : Alterations of Blood Plasma Metabolites, Including Kynurenine and Tryptophan, in Bipolar Disorder., Neuropsychiatric Disease and Treatment, 21, 1067-1073, 2025. (出版サイトへのリンク) ● Publication site (DOI): 10.2147/NDT.S508021 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-105006852907 (DOI: 10.2147/NDT.S508021, Elsevier: Scopus)

国際会議:

1.	Hidehiro Umehara, Kazuyuki Matsumoto, Tomohiko Nakayama, Hiroya Matsuda, Masahito Nakataki, Takaki Fukumori, Munenaga Koda, Kikuchi Keita, XIN KANG, Minoru Yoshida and Shusuke Numata : Deep Learning-Derived Multimodal Emotional Discordance During Anger Narratives and Its Association With Depression and Suicidal Ideation in Adolescents and Young Adults: The Moderating Role of Autistic Traits, 27th World Congress of IACAPAP 2026, Jul. 2026.

国内講演発表:

1.	上山佑一郎, 松田宙也, 中山知彦, 中瀧理仁, 沼田周助 : 修正型電気けいれん療法中に遷延する高振幅徐波を認めた2症例の検討, 【第65回中国・四国精神神経学会(2025.11.27-28 山口)】, 2025年11月.
2.	松田宙也, 中瀧理仁, 伊賀淳一, 長谷川尚美, 大井一高, 牧之段学, 富岡有紀子, 吉野祐太, 松本純弥, 中込和幸, 橋本亮太, 上野修一, 沼田周助 : 精神疾患横断的血漿トリプトファンとキヌレニン濃度の検討, BPCNPNP2025合同年会, 2025年11月.
3.	乾友浩, 一宮由貴, 三木幸代, 岡本恵, 松田宙也, 沼田周助 : メサドンをadd-on法で導入し良好な疼痛コントロールを得た難治性がん疼痛の2例, 第30回日本緩和医療学会学術大会, 2025年7月.
4.	吉田慧司, 松田宙也, 山田直輝, 中瀧理仁, 沼田周助 : 強迫性障害を合併したドゥ・ラ・トゥレット症候群の一例, 第64回中国・四国精神神経学会, 2024年11月.
5.	梅原英裕, 武田知也, 増田太利志, 松田宙也, 山田直輝 : 猜疑心・敵意バイアスをターゲットとした青年期集団認知療法による内因性オキシトシンの変化., 第65回日本児童青年精神医学会, 2024年10月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

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