Tokushima University / Educator and Researcher Directory --- Miyakami, Yuko

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Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Diagnostic Pathology ⟩

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Academic Paper (Unrefereed Paper):

1.	Takayuki Noma, Masaaki Nishi, Chie Takasu, Yuuma Wada, Kozo Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto, Yuko Miyakami, Kengo Atsumi, Hisanori Uehara and Mitsuo Shimada : Conversion surgery after successful response to chemotherapy (S-1 + oxaliplatin + nivolumab) in a patient with stage IV gastric cancer with peritoneal metastasis (P1, CY1): a case report., International Cancer Conference Journal, 13, 1, 11-16, 2023. (Summary) We here present a case report of a patient with Stage IV gastric cancer with peritoneal metastasis (P1, CY1) who underwent conversion surgery after a successful response to chemotherapy (S-1 + oxaliplatin + nivolumab). The patient was a woman in her 60 s. Her chief complaint was epigastric pain. Upper gastrointestinal endoscopy showed Type 4 advanced carcinoma on the lesser curvature of the gastric body. Biopsy showed Group 5 (poorly differentiated adenocarcinoma) and HER2 was negative. Staging laparoscopy revealed seeding in the round ligament of the liver (P1) and adenocarcinoma cells in ascites (CY1). Ten courses of chemotherapy (S-1 + oxaliplatin + nivolumab) were administered, after which contrast-enhanced computed tomography showed that the primary tumor had shrunk and seeding was no longer detectable. Upper gastrointestinal endoscopy revealed scar-like changes. A second staging laparoscopy revealed that ascites cytology was negative and a biopsy of the round ligament of the liver showed no malignant cells (P0, CY0). Conversion surgery comprising laparoscopic total gastrectomy with D2 lymph node dissection and resection of the round ligament of the liver was performed. The postoperative course was uneventful. Histopathological examination of the resected specimen revealed no tumor cells in the gastric mesentery or the round ligament of the liver. The pathological diagnosis was gastric cancer [M, U, L, Less, Ant, Post, type4, T3(SS), N0, M0 (H0, P0, CY0), ypStage IIA]. Adjuvant chemotherapy (S-1) was commenced. The patient is still alive 7 months later with no evidence of recurrence. (Link to Publication Site) ● Publication site (DOI): 10.1007/s13691-023-00628-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38187176 ● Search Scopus @ Elsevier (PMID): 38187176 ● Search Scopus @ Elsevier (DOI): 10.1007/s13691-023-00628-4 (DOI: 10.1007/s13691-023-00628-4, PubMed: 38187176)

Proceeding of International Conference:

1.	Mayuko Shimizu, Yuko Miyakami, Minoru Matsumoto, Yoshimura Kentaro, Tsutsui Akemi, Tsuchiyama Yosuke, Takaguchi Koichi, Takeda Sén and Koichi Tsuneyama : An algorithm based on serum phospholipid profiles to predict liver fibrosis degree in metabolic dysfunctionassociated steatotic liver disease, EASL, 2024.

Proceeding of Domestic Conference:

1.	Yuko Miyakami, Sumida Satoshi, Takayama Yoshimasa, Yoshimi Bando, Hisanori Uehara and Michiko Yamashita : A case of classic Hodgkin lymphoma nodular sclerosis, relapsing in the skin with T-cell receptor gene rearrangement, The journal of the Japanese Society of Lymphoreticular Tissue, Jun. 2024.
2.	Mayuko Shimizu, Yuko Miyakami, 筒井朱美 and Koichi Tsuneyama : 複数の血清リン脂質を用いたNASH線維化バイオマーカーの検討, 第59回肝臓学会総会, Jun. 2023.