徳島大学 / 教育研究者総覧 --- 宮上侑子

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徳島大学 ⟩ 病院 ⟩ 診療科 ⟩ 病理診断科 ⟩

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著書・論文

学術論文(審査論文):

1.	Honoka Nakahara, Mayuko Shimizu, Shotaroh Tachibana, Orgil Jargalsaikhan, Cai Qinyi, Yuko Miyakami, Hirohisa Ogawa, Satoru Matsuda and Koichi Tsuneyama : Association of lipids in lipoprotein subfractions with liver fibrosis in a mouse model of metabolic dysfunction-associated steatohepatitis., The Journal of Medical Investigation : JMI, 72, 3.4, 375-384, 2025. (要約) Metabolic dysfunction-associated steatohepatitis (MASH) exhibits inflammation and fibrosis in addition to lipid accumulation in the liver, which may progress to cirrhosis and liver failure. This study investigated whether the serum lipoprotein subfraction reflects fibrosis severity in a MASH mouse model. Nine-week-old male A/J and C57BL6/J mice were fed a high-fat/cholesterol/cholate-based diet to induce fibrotic MASH. To generate fibrosis of varying severity, mice were fed two diets with different cholesterol concentrations (1.25% and 2.5%). After 9 weeks of feeding, serum cholesterol and triglyceride levels of each lipoprotein were comprehensively analyzed, including chylomicron, very-large low-density lipoprotein, low-density lipoprotein (LDL), and high-density lipoprotein (HDL), with 20 subclasses according to particle size. Serum levels of very-large HDL-cholesterol, very-small HDL-cholesterol, very-small HDL-triglycerides, and very-small LDL-cholesterol were significantly higher in the stage 2 fibrosis group than the stage 1 fibrosis group. Serum very-small LDL-cholesterol levels were correlated with histological severity of MASH, which reportedly increases with the progression of MASH in humans. In conclusion, the serum lipoprotein subfraction reflects liver fibrosis severity even in early phase, independent of the severity of other MASH lesions in MASH model mice. Fractionating HDL, which have been measured in clinical practice, may help establish noninvasive markers of liver fibrosis. J. Med. Invest. 72 : 375-384, August, 2025. (キーワード) Animals / Male / Mice / Liver Cirrhosis / Mice, Inbred C57BL / Lipoproteins / Disease Models, Animal / Fatty Liver / Lipids (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.72.375 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41183940 ● Search Scopus @ Elsevier (PMID): 41183940 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.72.375 (DOI: 10.2152/jmi.72.375, PubMed: 41183940)

学術論文(紀要・その他):

1.	Takayuki Noma, Masaaki Nishi, Chie Takasu, Yuuma Wada, Kozo Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto, Yuko Miyakami, Kengo Atsumi, Hisanori Uehara and Mitsuo Shimada : Conversion surgery after successful response to chemotherapy (S-1 + oxaliplatin + nivolumab) in a patient with stage IV gastric cancer with peritoneal metastasis (P1, CY1): a case report., International Cancer Conference Journal, 13, 1, 11-16, 2023. (要約) We here present a case report of a patient with Stage IV gastric cancer with peritoneal metastasis (P1, CY1) who underwent conversion surgery after a successful response to chemotherapy (S-1 + oxaliplatin + nivolumab). The patient was a woman in her 60 s. Her chief complaint was epigastric pain. Upper gastrointestinal endoscopy showed Type 4 advanced carcinoma on the lesser curvature of the gastric body. Biopsy showed Group 5 (poorly differentiated adenocarcinoma) and HER2 was negative. Staging laparoscopy revealed seeding in the round ligament of the liver (P1) and adenocarcinoma cells in ascites (CY1). Ten courses of chemotherapy (S-1 + oxaliplatin + nivolumab) were administered, after which contrast-enhanced computed tomography showed that the primary tumor had shrunk and seeding was no longer detectable. Upper gastrointestinal endoscopy revealed scar-like changes. A second staging laparoscopy revealed that ascites cytology was negative and a biopsy of the round ligament of the liver showed no malignant cells (P0, CY0). Conversion surgery comprising laparoscopic total gastrectomy with D2 lymph node dissection and resection of the round ligament of the liver was performed. The postoperative course was uneventful. Histopathological examination of the resected specimen revealed no tumor cells in the gastric mesentery or the round ligament of the liver. The pathological diagnosis was gastric cancer [M, U, L, Less, Ant, Post, type4, T3(SS), N0, M0 (H0, P0, CY0), ypStage IIA]. Adjuvant chemotherapy (S-1) was commenced. The patient is still alive 7 months later with no evidence of recurrence. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s13691-023-00628-4 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38187176 ● Search Scopus @ Elsevier (PMID): 38187176 ● Search Scopus @ Elsevier (DOI): 10.1007/s13691-023-00628-4 (DOI: 10.1007/s13691-023-00628-4, PubMed: 38187176)

国際会議:

1.	Mayuko Shimizu, Yuko Miyakami, Minoru Matsumoto, Yoshimura Kentaro, Tsutsui Akemi, Tsuchiyama Yosuke, Takaguchi Koichi, Takeda Sén and Koichi Tsuneyama : An algorithm based on serum phospholipid profiles to predict liver fibrosis degree in metabolic dysfunctionassociated steatotic liver disease, EASL, 2024.

国内講演発表:

1.	宮上侑子, 住田智志, 高山良政, 坂東良美, 上原久典, 山下理子 : T細胞受容体遺伝子再構成を示し，皮膚に再発した結節硬化型古典的ホジキンリンパ腫の一例, 日本リンパ網内系学会会誌, 2024年6月.
2.	清水真祐子, 宮上侑子, 筒井朱美, 常山幸一 : 複数の血清リン脂質を用いたNASH線維化バイオマーカーの検討, 第59回肝臓学会総会, 2023年6月.