徳島大学 / 教育研究者総覧 --- 森田優

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徳島大学 ⟩ 大学院医歯薬学研究部 ⟩ 医学域 ⟩ 連携研究部門(医学域) ⟩ 寄附講座系(医学域) ⟩ 地域リウマチ・総合内科学 ⟩

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研究活動

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研究テーマ

著書・論文

学術論文(審査論文):

1.	Kaori Nii, Hirokazu Ogino, Hiroki Bando, Yuki Yamamoto, Koji Fujita, Hiroto Yoneda, Nobuhito Naito, Atsushi Mitsuhashi, Yutaka Morita, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Seidai Satou, Masaki Hanibuchi, Yuishin Izumi and Yasuhiko Nishioka : Immune checkpoint inhibitor-associated paraneoplastic cerebellar degeneration in a case of extensive-stage small-cell lung cancer with pre-existing anti-SOX1 antibody, The Journal of Medical Investigation : JMI, 72, 1.2, 172-176, 2025. (要約) Neurological immune-related adverse events can manifest as paraneoplastic neurological syndrome (PNS), especially in patients with small-cell lung cancer (SCLC). We herein report a 73-year-old man with SCLC treated with an immune checkpoint inhibitor (ICI) combined with chemotherapy. Although the chemo-immunotherapy induced a favorable response to SCLC, he later developed acute cerebellar ataxia. He was diagnosed with paraneoplastic cerebellar degeneration associated with anti-Sry-like high mobility group box 1 (SOX1) autoantibody. The antibody was also identified in serum collected at the diagnosis of SCLC and before ICI administration, which retrospectively suggested that the patient was at risk of ICI-induced PNS. J. Med. Invest. 72 : 172-176, February, 2025. (キーワード) anti-SOX1 autoantibody / immune checkpoint inhibitors / paraneoplastic cerebellar degeneration / small-cell lung cancer (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.72.172 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 40268441 ● Summary page in Scopus @ Elsevier: 2-s2.0-105003981938 (DOI: 10.2152/jmi.72.172, PubMed: 40268441, Elsevier: Scopus)
2.	Yohei Yabuki, Atsushi Mitsuhashi, Hirokazu Ogino, Aito Yoshida, Thi Na Nguyen, Hiroto Yoneda, Ryohiko Ozaki, Yuki Tsukazaki, Yutaka Morita, Hiroshi Nokihara, Seidai Satou, Tsutomu Shinohara, Masaki Hanibuchi and Yasuhiko Nishioka : Hypoxia-inducible factor-targeting therapy augmented the sensitivity to programmed death ligand-1 blockade by enhancing interferon-γ-induced chemokines in tumor cells, International Journal of Cancer, 156, 9, 1814-1825, 2024. (要約) Immune checkpoint inhibitors (ICIs) targeting programmed death ligand-1 (PD-L1) provide clinical benefits for various advanced malignancies. However, the predictive factors that determine sensitivity to ICIs have not been fully elucidated. We focused on tumor-derived CXCL10/11 as a pivotal factor that determines the response to PD-L1 blockade by regulating T cell accumulation and tumor angiogenesis. We previously reported that CXCL10/11 was upregulated by interferon (IFN)-γ in ICI-sensitive tumor cells but not in ICI-resistant cells, including mouse Lewis lung carcinoma (LLC). In the present study, gene silencing of tumor-derived CXCL10/11 induced resistance to PD-L1 blockade in AB1-HA mesothelioma cell-bearing mice. To identify the mechanisms underlying ICI resistance, we performed a microarray analysis to compare the IFN-γ-inducible genes between ICI-sensitive AB1-HA and ICI-resistant LLC in vitro. A pathway analysis based on microarray data indicated that hypoxia-inducible factor (HIF) 1A is the key signal that inhibits CXCL10/11 expression. We revealed that the HIF1A inhibitors echinomycin (EC) and YC-1 upregulated CXCL10/11 genes induced by IFN-γ in tumor cells in vitro. In addition, combination therapy with PD-L1 blockade and EC demonstrated synergistic antitumor effects in LLC-bearing mice. Combination therapy enhanced tumor infiltration of CD8 T cells and suppressed tumor angiogenesis. The present study suggests that HIF1A signaling in tumor cells dominates ICI resistance via the downregulation of tumor-derived CXCL10/11. (キーワード) angiogenesis / CXCL10/11 / HIF1A / immune checkpoint inhibitor / interferon-γ (徳島大学機関リポジトリ) ● Metadata: 2013332 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/ijc.35301 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39686841 ● Summary page in Scopus @ Elsevier: 2-s2.0-85212305972 (徳島大学機関リポジトリ: 2013332, DOI: 10.1002/ijc.35301, PubMed: 39686841, Elsevier: Scopus)
3.	Yuki Tsukazaki, Hirokazu Ogino, Yoshio Okano, Soji Kakiuchi, Shoko Harada, Yuko Toyoda, Yugo Matsumura, Seiya Ichihara, Takeshi Imakura, Rikako Matsumoto, Ryohiko Ozaki, Ei Ogawa, Yutaka Morita, Atsushi Mitsuhashi, Yohei Yabuki, Hiroto Yoneda, Masaki Hanibuchi, Kayoko Hase, Eiji Takeuchi, Takashi Haku and Yasuhiko Nishioka : Granulocyte colony-stimulating factor has the potential to attenuate the therapeutic efficacy of chemo-immunotherapy for extensive-stage small-cell lung cancer, International Journal of Clinical Oncology, 29, 10, 1451-1460, 2024. (要約) Granulocyte colony-stimulating factor (G-CSF) has the potential to attenuate the anti-tumor immune responses of T-cells by increasing immune suppressive neutrophils and myeloid-derived suppressor cells. However, the clinical impact of G-CSF on the efficacy of immunotherapy remains unknown. This multi-center retrospective analysis evaluated the impact of G-CSF in patients with extensive-stage small-cell lung cancer (ES-SCLC) treated with chemo-immunotherapy. We analyzed 65 patients with ES-SCLC who completed four cycles of induction chemo-immunotherapy and evaluated the effects of G-CSF on progression-free survival (PFS), overall survival (OS), and a durable response to immunotherapy (defined as PFS 12 months). Fifty patients (76.9%) received 1 dose of G-CSF. The PFS of the patients with G-CSF was poorer than that of the patients without G-CSF (median PFS 8.3 vs. 4.9 months, p = 0.009). The OS of the patients with G-CSF tended to be shorter, but not statistically significant, than that of the patients without G-CSF (median OS 24.3 vs. 16.4 months, p = 0.137). In the multivariate analysis, G-CSF administration was associated with poorer PFS (hazard ratio 2.78, 95% CI 1.36-5.69, p = 0.005) and was identified as a determinant of a durable response (odds ratio 0.18, 95% CI 0.04-0.80, p = 0.024). These results were consistent with other definitions of G-CSF administration (administration of 1 dose of pegfilgrastim, or either 5 doses of filgrastim or 1 dose of pegfilgrastim). G-CSF has the potential to attenuate the efficacy of immunotherapy; therefore, the indication for G-CSF during chemo-immunotherapy should be carefully considered for ES-SCLC. (キーワード) Chemo-immunotherapy / Extensive-stage small-cell lung cancer / Granulocyte colony-stimulating factor (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10147-024-02586-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39009900 ● Summary page in Scopus @ Elsevier: 2-s2.0-85198503607 (DOI: 10.1007/s10147-024-02586-0, PubMed: 39009900, Elsevier: Scopus)
4.	Kenya Miyamoto, Hirokazu Ogino, Takumi Kakimoto, Yugo Matsumura, Keiko Haji, Atsushi Mitsuhashi, Yutaka Morita, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Hiroto Yoneda, Seidai Satou, Masaki Hanibuchi, Yoshimi Bando, Hiroshi Nokihara and Yasuhiko Nishioka : Transformation of epidermal growth factor receptor mutated lung adenocarcinoma to small-cell carcinoma long after the cessation of tyrosine kinase inhibitor treatment: A case series and literature review., Respiratory Medicine Case Reports, 51, 102076, 2024. (要約) Histological transformation to small-cell lung cancer (SCLC) is a well-known mechanism of acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), and almost all patients receive EGFR-TKIs at the time of transformation. We herein report three cases of EGFR-mutated lung adenocarcinoma that transformed into SCLC long after the cessation of EGFR-TKIs. Rapid tumor progression and elevated SCLC marker levels were observed at the time of transformation. Our case highlights the importance of considering SCLC transformation throughout the clinical course. Careful observation of the tumor behavior and SCLC markers should be performed to avoid diagnostic delays. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.rmcr.2024.102076 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39027818 ● Search Scopus @ Elsevier (PMID): 39027818 ● Search Scopus @ Elsevier (DOI): 10.1016/j.rmcr.2024.102076 (DOI: 10.1016/j.rmcr.2024.102076, PubMed: 39027818)
5.	Kenya Miyamoto, Hirokazu Ogino, Takumi Kakimoto, Yugo Matsumura, Keiko Haji, Atsushi Mitsuhashi, Yutaka Morita, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Hiroto Yoneda, Seidai Satou, Masaki Hanibuchi, Yoshimi Bando, Hiroshi Nokihara and Yasuhiko Nishioka : Transformation of epidermal growth factor receptor mutated lung adenocarcinoma to small-cell carcinoma long after the cessation of tyrosine kinase inhibitor treatment: A case series and literature review, Respiratory Medicine Case Reports, 51, 102076, 2024. (キーワード) Acquired resistance / Epidermal growth factor receptor / Non-small-cell lung cancer / Small-cell lung cancer transformation / Tyrosine kinase inhibitors (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.rmcr.2024.102076 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85196709618 (DOI: 10.1016/j.rmcr.2024.102076, Elsevier: Scopus)

国際会議:

1.	Yuki Tsukazaki, Hirokazu Ogino, Yoshio Okano, Soji Kakiuchi, Shoko Harada, Yuko Toyoda, Yugo Matsumura, Seiya Ichihara, Takeshi Imakura, Rikako Matsumoto, Ryohiko Ozaki, Ei Ogawa, Yutaka Morita, Atsushi Mitsuhashi, Yohei Yabuki, Hiroto Yoneda, Masaki Hanibuchi, Kayoko Hase, Eiji Takeuchi, Takashi Haku and Yasuhiko Nishioka : The Conflicting Impacts of G-CSF on the Therapeutic Efficacy of Chemoimmunotherapy for Extensive Stage Small Cell Lung Cancer, 2024 World Conference on Lung Cancer, San Diego, Sep. 2024.

国内講演発表:

1.	塚﨑佑貴, 荻野広和, 岡野義夫, 柿内聡司, 豊田優子, 松本利加子, 尾崎領彦, 森田優, 三橋惇志, 矢葺洋平, 埴淵昌毅, 長谷加容子, 竹内栄治, 葉久貴司, 西岡安彦 : G-CSFが進展型小細胞肺癌における化学免疫療法の治療効果に及ぼす影響を検討した多施設共同後方視的解析, 第65回日本肺癌学会学術集会, 2024年11月.
2.	塚﨑佑貴, 荻野広和, 岡野義夫, 柿内聡司, 豊田優子, 松本利加子, 尾崎領彦, 森田優, 三橋惇志, 矢葺洋平, 埴淵昌毅, 長谷加容子, 竹内栄治, 葉久貴司, 西岡安彦 : G-CSF が進展型小細胞肺癌に対する化学免疫療法の治療効果に及ぼす影響に関する解析, 第62回日本癌治療学会学術集会, 2024年10月.
3.	三橋惇志, 小山壱也, 荻野広和, 矢葺洋平, 尾崎領彦, 塚﨑佑貴, 森田優, 吉田碧人, 軒原浩, 埴淵昌毅, 西岡安彦 : Fibrocyte 制御によるがん免疫排除克服に向けた治療戦略, 第83回日本癌学会学術総会, 2024年9月.
4.	宮本憲哉, 埴淵昌毅, 磯村祐太, 森田優, 村上行人, 坂東弘基, 尾崎領彦, 香川耕造, 米田浩人, 荻野広和, 西岡安彦 : 気管支鏡後の呼吸器感染症ハイリスク症例における予防的抗菌薬投与の意義についての後方視的研究, 第47回日本呼吸器内視鏡学会学術集会, 2024年6月.

その他・研究会:

1.	森田優, 村上行人, 坂東弘基, 宮本憲哉, 磯村祐太, 梶本達也, 近藤圭大, 香川耕造, 荻野広和, 佐藤正大, 埴淵昌毅, 西岡安彦 : 気管支鏡で診断した肺内神経鞘腫の一例, 第33回日本呼吸器内視鏡学会中国四国支部会, 2024年11月.
2.	近藤圭大, 村上行人, 坂東弘基, 塚﨑佑貴, 荻野広和, 松本利加子, 森田優, 三橋惇志, 尾崎領彦, 矢葺洋平, 佐藤正大, 埴淵昌毅, 岡野義夫, 柿内聡司, 豊田優子, 長谷加容子, 竹内栄治, 葉久貴司, 西岡安彦 : 進展型小細胞肺癌において顆粒球コロニー刺激因子が化学免疫療法の治療効果に及ぼす影響, 第269回徳島医学会学術集会, 2024年7月.