Tokushima University / Educator and Researcher Directory --- Sugimoto, Tatsuro

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Tokushima University ⟩ University Hospital ⟩ 先端医科医療開発研究プロジェクト ⟩
Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Pediatrics,Obstetrics and Gynecology ⟩ Obstetrics snd Gynecology ⟩
Tokushima University ⟩ Faculty of Medicine ⟩ School of Medicine ⟩ Course of Human Development ⟩ Obstetrics and Gynecology ⟩

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Research

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Atsuko Yoshida, Takashi Kaji, Tatsuro Sugimoto, Ayuka Mineda, Shiroh Fujii and Takeshi Iwasa : Fatal Intratumoral Hemorrhage in Mediastinal Diffuse Large B-Cell Lymphoma During Pregnancy: A Case Report, The Journal of Obstetrics and Gynaecology Research, 52, 3, e70232, 2026. (Summary) We report a pregnant woman with diffuse large B-cell lymphoma (DLBCL) presenting as a massive mediastinal tumor causing dyspnea. A 34-year-old multiparous woman was diagnosed with the tumor at 16 weeks of gestation. During attempts at airway management using ECMO cannulation and intubation, she developed cardiopulmonary arrest due to airway compromise but was resuscitated. R-CHOP chemotherapy was initiated empirically, and subsequent biopsy confirmed DLBCL, leading to continuation of therapy using DA-EPOCH-R. Despite repeated discussions, including the option of pregnancy termination, the patient strongly wished to continue the pregnancy. Partial tumor shrinkage was achieved; however, at 24 weeks, she developed sudden massive hemoptysis and cardiopulmonary arrest, which proved fatal despite resuscitation. Postmortem imaging demonstrated tumoral hemorrhage with bronchial communication. Although tumoral hemorrhage is a rare complication of lymphoma, it should be recognized as a possible cause of sudden death in malignant disease. This case highlightsthe potential for catastrophic tumoral hemorrhage during chemotherapy and the complex ethical dilemmas surrounding pregnancy continuation. (Keyword) diffuse large B-cell lymphoma / ECMO / malignant lymphoma / pregnancy / tumoral hemorrhage (Link to Publication Site) ● Publication site (DOI): 10.1111/jog.70232 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41813081 ● Summary page in Scopus @ Elsevier: 2-s2.0-105032410738 (DOI: 10.1111/jog.70232, PubMed: 41813081, Elsevier: Scopus)

Academic Paper (Unrefereed Paper):

1.	Takeshi Iwasa, Hiroki Noguchi, Risa Tanano, Erika Yamanaka, Asuka Takeda, Kou Tamura, Hidenori Aoki, Tatsuro Sugimoto, Hikari Sasada, Takaaki Maeda, Saki Minato, Shota Yamamoto, Hiroaki Inui, Tomohiro Kagawa, Atsuko Yoshida, Ayuka Mineda, Mari Nii, Riyo Kinouchi, Kanako Yoshida, Yuri Yamamoto and Takashi Kaji : Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory Animals., International Journal of Molecular Sciences, 24, 23, 16567, 2023. (Summary) In recent years, the effects of androgens on metabolic and body weight regulation systems and their underlying mechanisms have been gradually revealed in females. In women and experimental animals of reproductive age, androgen excess can adversely affect metabolic functioning, appetite, and body weight regulation. In addition, excess androgens can increase the risk of metabolic disorders, such as obesity, insulin resistance, and diabetes. These unfavorable effects of androgens are induced by alterations in the actions of hypothalamic appetite-regulatory factors, reductions in energy expenditure, insulin resistance in skeletal muscle, and β-cell dysfunction. Interestingly, these unfavorable effects of androgens on metabolic and body-weight regulation systems are neither observed nor evident in ovariectomized animals and post-menopausal women, indicating that the adverse effects of androgens might be dependent on the estrogen milieu. Recent findings may provide novel sex- and age-specific strategies for treating metabolic diseases. (Keyword) Animals / Humans / female / Androgens / Insulin Resistance / Obesity / Metabolic Diseases / Animals, Laboratory / Polycystic Ovary Syndrome (Tokushima University Institutional Repository) ● Metadata: 2000318 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijms242316567 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38068890 ● Search Scopus @ Elsevier (PMID): 38068890 ● Search Scopus @ Elsevier (DOI): 10.3390/ijms242316567 (Tokushima University Institutional Repository: 2000318, DOI: 10.3390/ijms242316567, PubMed: 38068890)

Proceeding of Domestic Conference:

1.	Kanako Yoshida, Hiroki Noguchi, Tatsuro Sugimoto, Hidenori Aoki, Hiroaki Inui, Tomohiro Kagawa, Riyo Kinouchi and Takeshi Iwasa : 卵巣子宮内膜症性嚢胞破裂後に膿胸を発症した一例, 第47回日本エンドメトリオーシス学会, Jan. 2026.

Et cetera, Workshop:

1.	Tatsuro Sugimoto, Takashi Kaji, 吉本夏実, Ayuka Mineda, Atsuko Yoshida, Masashi Suzue, Ryuji Nakagawa, Hiroki Ishibashi and Takeshi Iwasa : 胎児期にshort gapと診断し得たC型食道閉鎖の一例, 第121回徳島周産期研究会, Jun. 2025.