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徳島大学大学院医歯薬学研究部歯学域先端歯学教育研究プロジェクト
徳島大学大学院医歯薬学研究部歯学域口腔科学部門基礎歯学系口腔生命科学
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研究活動

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専門分野

免疫学 (Immunology)

研究テーマ

自己免疫疾患発症のメカニズムに関する研究 (自己免疫 (autoimmunity), 胸腺 (thymus))

著書・論文

学術論文(審査論文):

1. Satoru Kisoda, Wenhua Shao, Natsumi Fujiwara, Yasuhiro Mouri, Takaaki Tsunematsu, Shengjian Jin, Rieko Arakaki, Naozumi Ishimaru and Yasusei Kudo :
Prognostic value of partial EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis.,
Oral Diseases, 2020.
(徳島大学機関リポジトリ: 114969,   DOI: 10.1111/odi.13351,   PubMed: 32277532)
2. Hitoshi Nishijima, Tatsuya Kajimoto, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto, Minoru Matsumoto, Hiroshi Kawano, Yasuhiko Nishioka, Hisanori Uehara, Keisuke Izumi, Koichi Tsuneyama, Il-mi Okazaki, Taku Okazaki, Kazuyoshi Hosomichi, Ayako Shiraki, Makoto Shibutani, Kunitoshi Mitsumori and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).,
Journal of Autoimmunity, Vol.86, 75-92, 2018.
(徳島大学機関リポジトリ: 112347,   DOI: 10.1016/j.jaut.2017.09.006,   PubMed: 28931462)
3. Yasuhiro Mouri, Yoshihiro Ueda, Tomoyoshi Yamano, Minoru Matsumoto, Koichi Tsuneyama, Tatsuo Kinashi and Mitsuru Matsumoto :
Mode of tolerance induction and requirement for Aire are governed by the cell types that express self-antigen and those that present antigen,
The Journal of Immunology, Vol.199, No.12, 3959-3971, 2017.
(DOI: 10.4049/jimmunol.1700892,   PubMed: 29101311,   Elsevier: Scopus)
4. Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Fumiko Hirota, Ryoko Morita, Yasuhiro Mouri, Yasuhiko Nishioka and Mitsuru Matsumoto :
Aire expression is inherent to most medullary thymic epithelial cells during their differentiation program.,
The Journal of Immunology, Vol.195, No.11, 5149-5158, 2015.
(DOI: 10.4049/jimmunol.1501000,   PubMed: 26503950)
5. Hitoshi Nishijima, Satsuki Kitano, Hitoshi Miyachi, Junko Morimoto, Hiroshi Kawano, Fumiko Hirota, Ryoko Morita, Yasuhiro Mouri, Kiyoshi Masuda, Issei Imoto, Koichi Ikuta and Mitsuru Matsumoto :
Ectopic Aire expression in the thymic cortex reveals inherent properties of Aire as a tolerogenic factor within the medulla.,
The Journal of Immunology, Vol.195, No.10, 4641-4649, 2015.
(DOI: 10.4049/jimmunol.1501026,   PubMed: 26453754,   Elsevier: Scopus)
6. Yasuhiro Mouri, Hitoshi Nishijima, Hiroshi Kawano, Fumiko Hirota, Nobuo Sakaguchi, Junko Morimoto and Mitsuru Matsumoto :
NF-κB-Inducing Kinase in Thymic Stroma Establishes Central Tolerance by Orchestrating Cross-Talk with Not Only Thymocytes but Also Dendritic Cells.,
The Journal of Immunology, Vol.193, No.9, 4356-4367, 2014.
(DOI: 10.4049/jimmunol.1400389,   PubMed: 25261487)
7. Yumiko Nishikawa, Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Fumiko Hirota, Satoru Takahashi, Hervé Luche, Joerg Hans Fehring, Yasuhiro Mouri and Mitsuru Matsumoto :
Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.,
The Journal of Immunology, Vol.192, No.6, 2585-2592, 2014.
(DOI: 10.4049/jimmunol.1302786,   PubMed: 24516201,   Elsevier: Scopus)
8. Sumiko Yoshida, Ken-ichi Aihara, Yasumasa Ikeda, Yuka Sumitomo-Ueda, Ryoko Uemoto, Kazue Ishikawa, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Yasuhiro Mouri, Matomo Sakari, Takahiro Matsumoto, Ken-ichi Takeyama, Masashi Akaike, Mitsuru Matsumoto, Masataka Sata, Kenneth Walsh, Shigeaki Kato and Toshio Matsumoto :
Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling.,
Circulation, Vol.128, No.1, 60-71, 2013.
(DOI: 10.1161/CIRCULATIONAHA.113.001533,   PubMed: 23723256)
9. Yasuhiro Mouri, Masashi Yano, Miho Shinzawa, Yusuke Shimo, Fumiko Hirota, Yumiko Nishikawa, Takuro Nii, Hiroshi Kiyonari, Takaya Abe, Hisanori Uehara, Keisuke Izumi, Koji Tamada, Lieping Chen, Josef M. Penninger, Jun-ichiro Inoue, Taishin Akiyama and Mitsuru Matsumoto :
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma,
The Journal of Immunology, Vol.186, No.9, 5047-5057, 2011.
(DOI: 10.4049/jimmunol.1003533,   PubMed: 21441458)
10. Yumiko Nishikawa, Fumiko Hirota, Masashi Yano, Kitajima Hiroyuki, Miyazaki Jun-ichi, Kawamoto Hiroshi, Yasuhiro Mouri and Mitsuru Matsumoto :
Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation,
The Journal of Experimental Medicine, Vol.207, No.5, 963-971, 2010.
(DOI: 10.1084/jem.20092144,   PubMed: 20404099)
11. Masashi Yano, Noriyuki Kuroda, Hongwei Han, Makiko Meguro-Horike, Yumiko Nishikawa, Hiroshi Kiyonari, Kentaro Maemura, Yuchio Yanagawa, Kunihiko Obata, Satoru Takahashi, Tomokatsu Ikawa, Rumi Satoh, Hiroshi Kawamoto, Yasuhiro Mouri and Mitsuru Matsumoto :
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.,
The Journal of Experimental Medicine, Vol.205, No.12, 2827-2838, 2008.
(DOI: 10.1084/jem.20080046,   PubMed: 19015306)
12. Shino Niki, Kiyotaka Oshikawa, Yasuhiro Mouri, Fumiko Hirota, Akemi Matsushima, Masashi Yano, Hongwei Han, Yoshimi Bando, Keisuke Izumi, Masaki Matsumoto, Keiichi I. Nakayama, Noriyuki Kuroda and Mitsuru Matsumoto :
Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice,
The Journal of Clinical Investigation, Vol.116, No.5, 1292-1301, 2006.
(DOI: 10.1172/JCI26971,   PubMed: 16628255)
13. Dan Kinoshita, Fumiko Hirota, Tsuneyasu Kaisho, Michiyuki Kasai, Keisuke Izumi, Yoshimi Bando, Yasuhiro Mouri, Akemi Matsushima, Shino Niki, Hongwei Han, Kiyotaka Oshikawa, Noriyuki Kuroda, Masahiko Maegawa, Minoru Irahara, Kiyoshi Takeda, Shizuo Akira and Mitsuru Matsumoto :
Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance.,
The Journal of Immunology, Vol.176, No.7, 3995-4002, 2006.
(PubMed: 16547234,   Elsevier: Scopus)
14. Noriyuki Kuroda, Tasuku Mitani, Naoki Takeda, Naozumi Ishimaru, Rieko Arakaki, Yoshio Hayashi, Yoshimi Bando, Keisuke Izumi, Takeshi Takahashi, Takashi Nomura, Shimon Sakaguchi, Tomoo Ueno, Yousuke Takahama, Daisuke Uchida, Shijie Sun, Fumiko Kajiura, Yasuhiro Mouri, Hongwei Han, Akemi Matsushima, Gen Yamada and Mitsuru Matsumoto :
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice,
The Journal of Immunology, Vol.174, No.4, 1862-1870, 2005.
(DOI: 10.3410/f.1024264.287833,   PubMed: 15699112)
15. Hiroko Akiyoshi, Shigetsugu Hatakeyama, Jukka Pitkanen, Yasuhiro Mouri, Vassilis Doucas, Jun Kudoh, Kyoko Tsurugaya, Daisuke Uchida, Akemi Matsushima, Kiyotaka Oshikawa, Keiichi I. Nakayama, Nobuyoshi Shimizu, Part Peterson and Mitsuru Matsumoto :
Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner,
The Journal of Biological Chemistry, Vol.279, No.32, 33984-33991, 2004.
(DOI: 10.1074/jbc.M400702200,   PubMed: 15150263)

総説・解説:

1. 松本 満, 西川 裕美子, 毛利 安宏, 松本 穣, 西嶋 仁 :
T細胞の中枢免疫トレランスの機序,
月​刊​臨​床​免​疫​・​ア​レ​ル​ギ​ー​科​, Vol.60, No.2, 70-77, 2013年7月.
(CiNii: 40019752075)
2. 西嶋 仁, 毛利 安宏, 西川 裕美子, 松本 満 :
AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化,
生化学, Vol.85, No.7, 600, 2013年7月.
3. Mitsuru Matsumoto, Yumiko Nishikawa, Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto and Yasuhiro Mouri :
Which model better fits the role of Aire in the establishment of self-tolerance: the transcription model or the maturation model?,
Frontiers in Immunology, Vol.4, 1-4, Jul. 2013.
(DOI: 10.3389/fimmu.2013.00210,   PubMed: 23885257,   Elsevier: Scopus)

国際会議:

1. Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity through augmented expression of AIRE,
7th International Workshop of Kyoto T Cell Conference, Kyoto, Japan, Mar. 2017.
2. Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity through augmented expression of human AIRE in mice,
Controversies in Rheumatology and Autoimmunity 2017, Bologna, Italy, Mar. 2017.
3. Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Mitsuru Matsumoto :
Aire expression is inherent to all medullary thymic epithelial cells during their differentiation program,
The 4th European Congress of Immunology, Vienna, Austria, Sep. 2015.
4. Mitsuru Matsumoto, Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Yasuhiko Nishioka :
Aire expression is inherent properties of all medullary thymic epithelial cells during their differentiation program,
Venice Thymus Meeting 2015, Venice, Italy, Apr. 2015.
5. Hitoshi Nishijima, Junko Morimoto, Hiroshi Kawano, Yasuhiro Mouri, Koichi Ikuta and Mitsuru Matsumoto :
Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary thymic microenvironment,
ThymOz 7, Heron Island, Australia, Apr. 2014.
6. Mitsuru Matsumoto, Junko Morimoto, Hiroshi Kawano, Yasuhiro Mouri and Hitoshi Nishijima :
Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary microenvironment,
9th International Congress on Autoimmunity, Nice, France, Mar. 2014.
7. Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri, Yumiko Nishikawa, Kouichi Ikuta and Mitsuru Matsumoto :
Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor within medullary microenvironment,
第3回 眉山免疫シンポジウム, Feb. 2014.
8. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their maturation program,
15th ICI2013, Milan, Italy, Aug. 2013.
9. Mitsuru Matsumoto, Yumiko Nishikawa, Hitoshi Nishijima, Minoru Matsumoto, Fumiko Hirota, Satoru Takahashi, Hervé Luche, Hans Fehling Joerg and Yasuhiro Mouri :
Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program,
The 6th International Workshop of Kyoto T Cell Conference, Kyoto, Japan, Jun. 2013.
10. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Temporal fate-mapping study reveals essential roles of Aire in the maturation program of Aire-expressing cell lineage,
Immunology 2013 - AAI Annual Meeting, Honolulu, Hawaii, May 2013.
11. Yumiko Nishikawa, Yasuhiro Mouri, Hitoshi Nishijima and Mitsuru Matsumoto :
Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their full maturation program,
Controversies in Rheumatology and Autoimmunity (CORA 2011), Budapest, Hungary, Apr. 2013.
12. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Essential roles of Aire in the maturation program of Aire-expressing cell lineage(s) revealed by temporal fate-mapping approach,
The 10th International Conference on New Trends in Immunosuppression and Immunotherapy, Barcelona, Spain, Mar. 2013.
13. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri, Fumiko Hirota and Hitoshi Nishijima :
Temporal fate-mapping reveals essential roles of Aire in the maturation program of mTECs,
ThymUS 2012, Florida, USA, Nov. 2012.
14. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Functional analysis of Aire, a gene responsible for the hereditary type of autoimmune disease,
Days of Molecular Medicine 2012, Wien, Austria, Oct. 2012.
15. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Aire controls organization of thymic microenvironment for the establishment of self tolerance,
European Congress of Immunology 2012, Glasgow, Scotland, Sep. 2012.
16. Yasuhiro Mouri, Yumiko Nishikawa, Hitoshi Nishijima and Mitsuru Matsumoto :
AIRE-dependent organization of thymic microenvironment for the establishment of self tolerance,
5th Congress of the Federation of Immunological Societies of Asia Oceania, New Delhi, India, Mar. 2012.
17. Hitoshi Nishijima, Yasuhiro Mouri, Yumiko Nishikawa and Mitsuru Matsumoto :
Cell-cycle dependent phosphorylation of AIRE protein exogenously expressed in HeLa cells,
4th International Conference on Drug Discovery & Therapy, Dubai, UAE, Feb. 2012.
18. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Expression of Aire, a gene responsible for autoimmune disease, in ES cells,
Cell Symposia: Stem Cell Programming & Re-programming, Lisbon, Portugal, Dec. 2011.
19. Mitsuru Matsumoto, Yasuhiro Mouri, Yumiko Nishikawa and Hitoshi Nishijima :
Aire-dependent organization of thymic microenvironment for the establishment of self tolerance,
5th Asian Congress on Autoimmunity, Suntec City, Singapore, Nov. 2011.
20. Mitsuru Matsumoto, Yasuhiro Mouri, Yumiko Nishikawa and Hitoshi Nishijima :
Role of self-antigen expressed by Aire-expressing cells in the negative selection process,
5th International Conference on Autoimmunity: Mechanisms and Novel Treatments, Hersonissos, Crete, Greece, Sep. 2011.
21. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Aire-dependent organization of thymic microenvironment for the establishment of self tolerance,
EUThyme-Rolduc Meeting, Leeuwenhorst, The Netherlands, May 2011.
22. Yasuhiro Mouri, Masashi Yano, Miho Shinzawa, Yusuke Shimo, Yumiko Nishikawa, Koji Tamada, Lieping Chen, Josef M. Penninger, Jun-ichiro Inoue, Taishin Akiyama and Mitsuru Matsumoto :
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma,
13th International TNF Conference, TNF 2011, Awaji, Hyogo, May 2011.
23. Mitsuru Matsumoto, Yumiko Nishikawa, Hitoshi Nishijima and Yasuhiro Mouri :
Role of Aire in the organization of thymic microenvironment,
Controversies in Rheumatology and Autoimmunity (CORA 2011), Florence, Italy, Mar. 2011.
24. Yumiko Nishikawa, Yasuhiro Mouri, Hitoshi Nishijima and Mitsuru Matsumoto :
Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance,
Cutting Edge Immunology and its Clinical Application, Hulshort, The Netherlands, Mar. 2011.
25. Yasuhiro Mouri, Yumiko Nishikawa and Mitsuru Matsumoto :
Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes,
14th International Congress of Immunology, Kobe, Aug. 2010.
26. Yumiko Nishikawa, Yasuhiro Mouri and Mitsuru Matsumoto :
Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation,
14th International Congress of Immunology, Kobe, Aug. 2010.
27. Yasuhiro Mouri and Mitsuru Matsumoto :
Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes,
7th International Congress on Autoimmunity, Ljubljana, Slovenia, May 2010.
28. Mitsuru Matsumoto, Yumiko Nishikawa, Fumiko Hirota and Yasuhiro Mouri :
AIRE and autoimmune disease,
The 19th International Rheumatology Symposium, Kobe, Apr. 2010.
29. Mitsuru Matsumoto, Yumiko Nishikawa, Fumiko Hirota, Masashi Yano, Hiroshi Kawamoto and Yasuhiro Mouri :
Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation,
ThymOz VI, Gladstone, Australia, Mar. 2010.
30. Mitsuru Matsumoto, Yumiko Nishikawa, Masashi Yano, Fumiko Hirota and Yasuhiro Mouri :
Aire-dependent organization of thymic microenvironment,
International KTCC 2009, Kyoto, Jun. 2009.
31. Yasuhiro Mouri, Masashi Yano and Mitsuru Matsumoto :
Roles of NIK in thymic epithelial cells for the establishment of central tolerance.,
12th International TNF Conference, Madrid, Apr. 2009.

国内講演発表:

1. Hitoshi Nishijima, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto and Mitsuru Matsumoto :
Possible defect in the Treg production in mice overexpressing AIRE/Aire which exhibit muscle-specific autoimmunity,
第45回日本免疫学会学術集会, Dec. 2016.
2. Junko Morimoto, Yumiko Nishikawa, Hiroshi Kawano, Yasuhiro Mouri, Hitoshi Nishijima and Mitsuru Matsumoto :
A novel Aire-dependent subset of medullary thymic epithelial cells that express Ly6 family protein,
第44回日本免疫学会学術集会, Nov. 2015.
3. Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto, Hiroshi Kawano and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity by the additive expression of AIRE,
第44回日本免疫学会学術集会, Nov. 2015.
4. Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri, Hiroshi Kawano, Koichi Ikuta and Mitsuru Matsumoto :
Approaches to identify Aire-regulated non-tissue-restricted antigen genes by the ectopic expression of Aire in thymic cortex,
第43回日本免疫学会学術集会, Dec. 2014.
5. Hiroshi Kawano, Junko Morimoto, Yasuhiro Mouri, Hitoshi Nishijima, Yasuhiko Nishioka and Mitsuru Matsumoto :
Unexpected disturbance of the development of medullary thymic epithelial cells at immature stages by the long-term ablation of mature Aire-expressing cells,
第43回日本免疫学会学術集会, Dec. 2014.
6. Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri, Yumiko Nishikawa, Kouichi Ikuta and Mitsuru Matsumoto :
Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance,
第42回日本免疫学会総会, Dec. 2013.
7. 西嶋 仁, 毛利 安宏, 西川 裕美子, 松本 満 :
AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化,
第35回日本分子生物学会年会, 2012年12月.
8. 毛利 安宏, 西川 裕美子, 西嶋 仁, 松本 満 :
2つのトランスジェニックモデルにおける負の選択機構におけるAire依存性の相違,
第41回日本免疫学会学術集会, 2012年12月.

その他・研究会:

1. 西嶋 仁, 松岡 慶樹, 毛利 安宏, 森本 純子, 松本 満 :
ヒトAIRE トランスジェニックマウスに誘導される多発性筋炎病態の解析,
第36回日本胸腺研究会, 2017年2月.
2. 西嶋 仁, 梶本 達也, 松岡 慶樹, 毛利 安宏, 森本 純子, 河野 弘, 松本 満 :
NOD系統特異的に多発性筋炎様症状をもたらすゲノム領域の解析,
第14回四国免疫フォーラム, 2015年6月.
3. 西嶋 仁, 毛利 安宏, 西川 裕美子, 松本 満 :
AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化,
第54回日本生化学会 中国・四国支部例会, 2013年5月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

  • Aireによる胸腺内抗原提示細胞の機能制御の解析 (研究課題/領域番号: 16K08840 )
  • AIREの機能解析による自己免疫病態の解明 (研究課題/領域番号: 16H05342 )
  • 胸腺髄質上皮細胞による負の選択制御機構の解析 (研究課題/領域番号: 25860363 )
  • 根本的治療法確立のための遺伝性自己免疫疾患の病態解明 (研究課題/領域番号: 25293223 )
  • 難治性皮膚疾患・乾癬の免疫病態解析 (研究課題/領域番号: 22791078 )
  • 疾患モデルマウスを用いた遺伝性自己免疫疾患の病態解析 (研究課題/領域番号: 21390298 )
  • 研究者番号(80464353)による検索