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徳島大学 > 研究クラスター群 > 研究クラスター群 (登録) > 1704017 ヒトiPS細胞による顎顔面領域構成組織の再建技術の確立 >
徳島大学 > 研究クラスター群 > 研究クラスター群 (選定) > 1703003 分泌型シアル酸認識レクチンを用いた自己免疫疾患治療薬の開発 >

研究活動

専門分野

研究テーマ

著書・論文

著書:

1.山本 朗仁, 松原 弘記, 酒井 陽 :
歯髄幹細胞の可能性,
朝倉書店, 2012年.

学術論文(審査論文):

1.Hirohiko Okamura, Kaya Yoshida, Hiroyuki Morimoto, Jumpei Teramachi, Kazuhiko Ochiai, Tatsuji Haneji and Akihito Yamamoto :
Role of Protein Phosphatase 2A in Osteoblast Differentiation and Function.,
Journal of Clinical Medicine, Vol.6, No.3, 2017.
(DOI: 10.3390/jcm6030023,   PubMed: 28241467)
2.Fumiya Kano, Kohki Matsubara, Minoru Ueda, Hideharu Hibi and Akihito Yamamoto :
Secreted Ectodomain of Sialic Acid-Binding Ig-Like Lectin-9 and MCP-1 Synergistically Regenerate Transected Rat Peripheral Nerves by Altering Macrophage Polarity.,
Stem Cells, 2016.
(DOI: 10.1002/stem.2534,   PubMed: 27862629)
3.Marina Hirata, Masatoshi Ishigami, Yoshihiro Matsushita, Takanori Ito, Hisashi Hattori, Hideharu Hibi, Hidemi Goto, Minoru Ueda and Akihito Yamamoto :
Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis.,
Stem Cells Translational Medicine, Vol.5, No.10, 1416-1424, 2016.
(DOI: 10.5966/sctm.2015-0353,   PubMed: 27280796)
4.Takuya Matsumoto, Nobunori Takahashi, Toshihisa Kojima, Yutaka Yoshioka, Jun Ishikawa, Koichi Furukawa, Kenji Ono, Makoto Sawada, Naoki Ishiguro and Akihito Yamamoto :
Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages.,
Arthritis Research & Therapy, Vol.18, No.1, 2016.
(DOI: 10.1186/s13075-016-1035-9,   PubMed: 27267914)
5.Chiaki Shimojima, Hideyuki Takeuchi, Shijie Jin, Bijay Parajuli, Hisashi Hattori, Akio Suzumura, Hideharu Hibi, Minoru Ueda and Akihito Yamamoto :
Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis.,
The Journal of Immunology, Vol.196, No.10, 4164-4171, 2016.
(DOI: 10.4049/jimmunol.1501457,   PubMed: 27053763)
6.Masahito Fujio, Zhe Xing, Niyaz Sharabi, Ying Xue, Akihito Yamamoto, Hideharu Hibi, Minoru Ueda, Inge Fristad and Kamal Mustafa :
Conditioned media from hypoxic-cultured human dental pulp cells promotes bone healing during distraction osteogenesis.,
Journal of Tissue Engineering and Regenerative Medicine, 2015.
(DOI: 10.1002/term.2109,   PubMed: 26612624)
7.Jun Ishikawa, Nobunori Takahashi, Takuya Matsumoto, Yutaka Yoshioka, Noriyuki Yamamoto, Masaya Nishikawa, Hideharu Hibi, Naoki Ishigro, Minoru Ueda, Koichi Furukawa and Akihito Yamamoto :
Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis.,
Bone, Vol.83, 210-219, 2015.
(DOI: 10.1016/j.bone.2015.11.012,   PubMed: 26603475)
8.Satoshi Yamaguchi, Rei Shibata, Noriyuki Yamamoto, Masaya Nishikawa, Hideharu Hibi, Tohru Tanigawa, Minoru Ueda, Toyoaki Murohara and Akihito Yamamoto :
Dental pulp-derived stem cell conditioned medium reduces cardiac injury following ischemia-reperfusion.,
Scientific Reports, Vol.5, 16295, 2015.
(DOI: 10.1038/srep16295,   PubMed: 26542315)
9.Yuka Hattori, Hangsoo Kim, Naotake Tsuboi, Akihito Yamamoto, Shinichi Akiyama, Yiqin Shi, Takayuki Katsuno, Tomoki Kosugi, Minoru Ueda, Seiichi Matsuo and Shoichi Maruyama :
Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury.,
PLoS ONE, Vol.10, No.10, e0140121, 2015.
(DOI: 10.1371/journal.pone.0140121,   PubMed: 26509261)
10.Takako Izumoto-Akita, Shin Tsunekawa, Akihito Yamamoto, Eita Uenishi, Kota Ishikawa, Hidetada Ogata, Atsushi Iida, Makoto Ikeniwa, Kaori Hosokawa, Yasuhiro Niwa, Ryuya Maekawa, Yuichiro Yamauchi, Yusuke Seino, Yoji Hamada, Hideharu Hibi, Hiroshi Arima, Minoru Ueda and Yutaka Oiso :
Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic -cell function.,
BMJ Open Diabetes Research & Care, Vol.3, No.1, e000128, 2015.
(DOI: 10.1136/bmjdrc-2015-000128,   PubMed: 26504525)
11.Tsuneyuki Mita, Yoko Furukawa-Hibi, Hideyuki Takeuchi, Hisashi Hattori, Kiyofumi Yamada, Hideharu Hibi, Minoru Ueda and Akihito Yamamoto :
Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease.,
Behavioural Brain Research, Vol.293, 189-197, 2015.
(DOI: 10.1016/j.bbr.2015.07.043,   PubMed: 26210934)
12.Yoshihiro Matsushita, Masatoshi Ishigami, Kohki Matsubara, Megumi Kondo, Hirotaka Wakayama, Hidemi Goto, Minoru Ueda and Akihito Yamamoto :
Multifaceted therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for acute liver failure in rats,
Journal of Tissue Engineering and Regenerative Medicine, Vol.11, No.6, 1888-1896, 2015.
(DOI: 10.1002/term.2086,   PubMed: 28586545)
13.Hirotaka Wakayama, Naozumi Hashimoto, Yoshihiro Matsushita, Kohki Matsubara, Noriyuki Yamamoto, Yoshinori Hasegawa, Minoru Ueda and Akihito Yamamoto :
Factors secreted from dental pulp stem cells show multifaceted benefits for treating acute lung injury in mice.,
Cytotherapy, Vol.17, No.8, 1119-1129, 2015.
(DOI: 10.1016/j.jcyt.2015.04.009,   PubMed: 26031744)
14.Hiromi Fujii, Kohki Matsubara, Kiyoshi Sakai, Mikako Ito, Kinji Ohno, Minoru Ueda and Akihito Yamamoto :
Dopaminergic differentiation of stem cells from human deciduous teeth and their therapeutic benefits for Parkinsonian rats.,
Brain Research, Vol.1613, 59-72, 2015.
(DOI: 10.1016/j.brainres.2015.04.001,   PubMed: 25863132)
15.Kohki Matsubara, Yoshihiro Matsushita, Kiyoshi Sakai, Fumiya Kano, Megumi Kondo, Mariko Noda, Noboru Hashimoto, Shiro Imagama, Naoki Ishiguro, Akio Suzumura, Minoru Ueda, Koichi Furukawa and Akihito Yamamoto :
Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.,
The Journal of Neuroscience, Vol.35, No.6, 2452-2464, 2015.
(DOI: 10.1523/JNEUROSCI.4088-14.2015,   PubMed: 25673840)
16.Sun Yang, Finne-Wistrand Anna, Waag Thilo, Xing Zhe, Yassin Mohamed, Akihito Yamamoto, Mustafa Kamal, Steinmüller-Nethl Doris, Krueger Anke and Albertsson Ann-Christine :
Reinforced Degradable Biocomposite by Homogenously Distributed Functionalized Nanodiamond Particles,
Macromolecular Materials and Engineering, Vol.300, No.4, 436-447, 2015.
(DOI: 10.1002/mame.201400387,   Thomson Reuters: Web of Science™,   Elsevier: Scopus)
17.Yuji Ando, Kohki Matsubara, Jun Ishikawa, Masahito Fujio, Ryutaro Shohara, Hideharu Hibi, Minoru Ueda and Akihito Yamamoto :
Stem cell-conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms.,
Bone, Vol.61, 82-90, 2014.
(DOI: 10.1016/j.bone.2013.12.029,   PubMed: 24389414)
18.Akihito Yamamoto, Kohki Matsubara, Fumiya Kano and Kiyoshi Sakai :
Analysis of the neuroregenerative activities of mesenchymal stem cells in functional recovery after rat spinal cord injury.,
Methods in Molecular Biology, Vol.1213, 321-328, 2014.
(DOI: 10.1007/978-1-4939-1453-1_26,   PubMed: 25173394)
19.Akihito Yamamoto, Kiyoshi Sakai, Kohki Matsubara, Fumiya Kano and Minoru Ueda :
Multifaceted neuro-regenerative activities of human dental pulp stem cells for functional recovery after spinal cord injury.,
Neuroscience Research, Vol.78, 16-20, 2013.
(DOI: 10.1016/j.neures.2013.10.010,   PubMed: 24252618)
20.Takikawa Sachiko, Akihito Yamamoto, Saka Kiyoshi, Shohara Ryutaro, Iwase Akira, Kikkawa Fumitaka and Ueda Minoru :
Human umbilical cord-derived mesenchymal stromal cells promote sensory recovery in a spinal cord injury rat model,
Stem Cell Discovery, 2013.
21.Mari Yamagata, Akihito Yamamoto, Eisuke Kako, Naoko Kaneko, Kohki Matsubara, Kiyoshi Sakai, Kazunobu Sawamoto and Minoru Ueda :
Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice.,
Stroke, Vol.44, No.2, 551-554, 2012.
(DOI: 10.1161/STROKEAHA.112.676759,   PubMed: 23238858)
22.Ryutaro Shohara, Akihito Yamamoto, Sachiko Takikawa, Akira Iwase, Hideharu Hibi, Fumitaka Kikkawa and Minoru Ueda :
Mesenchymal stromal cells of human umbilical cord Wharton's jelly accelerate wound healing by paracrine mechanisms.,
Cytotherapy, Vol.14, No.10, 1171-1181, 2012.
(DOI: 10.3109/14653249.2012.706705,   PubMed: 22900957)
23.Kiyoshi Sakai, Akihito Yamamoto, Kohki Matsubara, Shoko Nakamura, Mami Naruse, Mari Yamagata, Kazuma Sakamoto, Ryoji Tauchi, Norimitsu Wakao, Shiro Imagama, Hideharu Hibi, Kenji Kadomatsu, Naoki Ishiguro and Minoru Ueda :
Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms.,
The Journal of Clinical Investigation, Vol.122, No.1, 80-90, 2011.
(DOI: 10.1172/JCI59251,   PubMed: 22133879)
24.Masahito Fujio, Akihito Yamamoto, Yuji Ando, Ryutaro Shohara, Kazuhiko Kinoshita, Tadashi Kaneko, Hideharu Hibi and Minoru Ueda :
Stromal cell-derived factor-1 enhances distraction osteogenesis-mediated skeletal tissue regeneration through the recruitment of endothelial precursors.,
Bone, Vol.49, No.4, 693-700, 2011.
(DOI: 10.1016/j.bone.2011.06.024,   PubMed: 21741502)
25.Yingsong Zhu, Akiko Tsuchida, Akihito Yamamoto, Keiko Furukawa, Orie Tajima, Noriyo Tokuda, Shinichi Aizawa, Takeshi Urano, Kenji Kadomatsu and Koichi Furukawa :
Expression and roles of a xenopus head-forming gene homologue in human cancer cell lines.,
Nagoya Journal of Medical Science, Vol.70, No.3-4, 73-82, 2008.
(PubMed: 18954025)
26.Kenryo Furushima, Akihito Yamamoto, Takashi Nagano, Mikihito Shibata, Hitoshi Miyachi, Takaya Abe, Naoko Ohshima, Hiroshi Kiyonari and Shinichi Aizawa :
Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings.,
Developmental Biology, Vol.306, No.2, 480-492, 2007.
(DOI: 10.1016/j.ydbio.2007.03.028,   PubMed: 17481602)
27.Takashi Nagano, Shoko Takehara, Maiko Takahashi, Shinichi Aizawa and Akihito Yamamoto :
Shisa2 promotes the maturation of somitic precursors and transition to the segmental fate in Xenopus embryos.,
Development, Vol.133, No.23, 4643-4654, 2006.
(DOI: 10.1242/dev.02657,   PubMed: 17065233)
28.Akihito Yamamoto, Takashi Nagano, Shoko Takehara, Masahiko Hibi and Shinichi Aizawa :
Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF.,
Cell, Vol.120, No.2, 223-235, 2005.
(DOI: 10.1016/j.cell.2004.11.051,   PubMed: 15680328)
29.Akihito Yamamoto, C Kemp, D Bachiller, D Geissert and M Robertis E De :
Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development.,
Genesis : the journal of genetics and development, Vol.27, No.2, 49-57, 2000.
(PubMed: 10890978)
30.A Sawada, A Fritz, J Y Jiang, Akihito Yamamoto, K Yamasu, A Kuroiwa, Y Saga and H Takeda :
Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites.,
Development, Vol.127, No.8, 1691-1702, 2000.
(PubMed: 10725245)
31.H S Kim, Akihito Yamamoto, T Bouwmeester, E Agius and M E Robertis :
The role of paraxial protocadherin in selective adhesion and cell movements of the mesoderm during Xenopus gastrulation.,
Development, Vol.125, No.23, 4681-4690, 1998.
(PubMed: 9806917)
32.K Takamiya, Akihito Yamamoto, K Furukawa, J Zhao, S Fukumoto, S Yamashiro, M Okada, M Haraguchi, M Shin, M Kishikawa, H Shiku, S Aizawa and K Furukawa :
Complex gangliosides are essential in spermatogenesis of mice: possible roles in the transport of testosterone.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.95, No.21, 12147-12152, 1998.
(PubMed: 9770454)
33.S Fukumoto, Akihito Yamamoto, T Hasegawa, K Abe, K Takamiya, M Okada, J Z Min, K Furukawa, H Miyazaki, Y Tsuji, G Goto, M Suzuki, H Shiku and K Furukawa :
Genetic remodeling of gangliosides resulted in the enhanced reactions to the foreign substances in skin.,
Glycobiology, Vol.7, No.8, 1111-1120, 1997.
(PubMed: 9455912)
34.M Robertis E De, S Kim, L Leyns, S Piccolo, D Bachiller, E Agius, A J Belo, Akihito Yamamoto, A Hainski-Brousseau, B Brizuela, O Wessely, B Lu and T Bouwmeester :
Patterning by genes expressed in Spemann's organizer.,
Cold Spring Harbor Symposia on Quantitative Biology, Vol.62, 169-175, 1997.
(PubMed: 9598349)
35.K Takamiya, Akihito Yamamoto, K Furukawa, S Yamashiro, M Shin, M Okada, S Fukumoto, M Haraguchi, N Takeda, K Fujimura, M Sakae, M Kishikawa, H Shiku, K Furukawa and S Aizawa :
Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.93, No.20, 10662-10667, 1996.
(PubMed: 8855236)
36.Akihito Yamamoto, S Yamashiro, S Fukumoto, M Haraguchi, M Atsuta, H Shiku and K Furukawa :
Site restricted and neuron dominant expression of alpha 2,8sialyltransferase gene in the adult mouse brain and retina.,
Glycoconjugate Journal, Vol.13, No.3, 471-480, 1996.
(PubMed: 8781978)
37.Akihito Yamamoto, M Haraguchi, S Yamashiro, S Fukumoto, K Furukawa, K Takamiya, M Atsuta, H Shiku and K Furukawa :
Heterogeneity in the expression pattern of two ganglioside synthase genes during mouse brain development.,
Journal of Neurochemistry, Vol.66, No.1, 26-34, 1996.
(PubMed: 8522963)
38.Akihito Yamamoto, S Yamashiro, K Takamiya, M Atsuta, H Shiku and K Furukawa :
Diverse expression of beta 1,4-N-acetylgalactosaminyltransferase gene in the adult mouse brain.,
Journal of Neurochemistry, Vol.65, No.6, 2417-2424, 1995.
(PubMed: 7595535)
39.S Yamashiro, M Haraguchi, K Furukawa, K Takamiya, Akihito Yamamoto, Y Nagata, O K Lloyd, H Shiku and K Furukawa :
Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.,
The Journal of Biological Chemistry, Vol.270, No.11, 6149-6155, 1995.
(PubMed: 7890749)
40.K Takamiya, Akihito Yamamoto, S Yamashiro, K Furukawa, M Haraguchi, M Okada, T Ikeda, H Shiku and K Furukawa :
T cell receptor-mediated stimulation of mouse thymocytes induces up-regulation of the GM2/GD2 synthase gene.,
FEBS Letters, Vol.358, No.1, 79-83, 1995.
(PubMed: 7821435)
41.M Haraguchi, S Yamashiro, Akihito Yamamoto, K Furukawa, K Takamiya, O K Lloyd, H Shiku and K Furukawa :
Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.91, No.22, 10455-10459, 1994.
(PubMed: 7937974)
42.K Yukawa, T Yasui, Akihito Yamamoto, H Shiku, T Kishimoto and H Kikutani :
Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and thymic stromal cells.,
Gene, Vol.133, No.2, 163-169, 1993.
(PubMed: 8224904)
43.R Suto, H Udono, Akihito Yamamoto, H Shiku and E Nakayama :
Effect of accessory cells on stimulation of murine T-cell leukemia with antibodies to the CD3/T cell antigen receptor complex.,
Gann : Japanese Journal of Cancer Research, Vol.84, No.4, 438-444, 1993.
(PubMed: 8514611)

学術レター:

1.Akihito Yamamoto, M Atsuta and K Hamatani :
Restricted expression of recombination activating gene (RAG-1) in mouse lymphoid tissues.,
Cell Biochemistry and Function, Vol.10, No.2, 71-77, 1992.
(DOI: 10.1002/cbf.290100202,   PubMed: 1628381)

総説・解説:

1.山本 朗仁 :

Clinical Neuroscience, Vol.30, No.10, 1102-1107, 2012年.
2.山本 朗仁 :

医学のあゆみ, Vol.239, No.8, 847-850, 2011年.
3.Akihito Yamamoto :
Molecular basis for specification of the vertebrate head field,
Interface Oral Health Science, 27-32, 2009.
4.Akihito Yamamoto :
Regulation of Wnt and FGF Signaling within the Endoplasmic Reticulum for Head Formation,
Journal of Oral Biosciences, Vol.48, No.1, 18-21, 2006.
(DOI: 10.2330/joralbiosci.48.18,   Elsevier: Scopus)

国際会議:

1.Jumpei Teramachi, Masahiro Hiasa, Oda Asuka, Hirofumi Tenshin, Ryota Amachi, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Akihito Yamamoto, Tatsuji Haneji, Toshio Matsumoto and Masahiro Abe :
Therapeutic impact of TAK1 inhibition on myeloma tumor progression and bone destruction,
Cancer and Bone Society Conference 2017, Indianapolis, May 2017.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

  • ヒト乳歯歯髄幹細胞とその有効成分を活用した筋萎縮性側索硬化症の新規治療法の開発 (研究課題/領域番号: 17K19666 )
  • 細胞外圧による間葉系幹細胞の分化運命制御機構の解明 (研究課題/領域番号: 17H04414 )
  • 歯髄幹細胞由来液性因子による口腔乾燥症の新規治療法の開発 (研究課題/領域番号: 17H04404 )
  • 糖尿病における歯髄幹細胞を利用した膵島移植の向上 (研究課題/領域番号: 16K09742 )
  • 過酷な培養環境に応答した細胞由来因子群による骨再生法 (研究課題/領域番号: 16H05540 )
  • 抗炎症性・組織再生型マクロファージを誘導する新規タンパク複合体による骨延長研究 (研究課題/領域番号: 15K15736 )
  • 急性肝不全モデル動物における歯髄由来幹細胞の効果-肝臓における炎症と再生の相関 (研究課題/領域番号: 15K08996 )
  • 組織再生スケールアップを目指した生体内血管網構築法の開発 (研究課題/領域番号: 26670863 )
  • 歯髄幹細胞由来の新規抗炎症性マクロファージ誘導因子を用いた末梢神経再生療法の開発 (研究課題/領域番号: 26293427 )
  • 骨延長法を模倣した延長装置を用いない広範囲顎骨再生法の開発 (研究課題/領域番号: 25293408 )
  • 細胞破壊と細胞組み込みによる新たな悪性腫瘍治療法の開発 (研究課題/領域番号: 23659942 )
  • 骨延長モデルを用いた幹細胞集積因子の機能解析 (研究課題/領域番号: 23659915 )
  • ヒト歯髄幹細胞の培養上清をもちいた中枢神経再生療法の開発 (研究課題/領域番号: 23659914 )
  • 血管構築を先行させる新たな骨再生法の開発 (研究課題/領域番号: 22390384 )
  • 歯髄幹細胞による中枢神経組織再生 (研究課題/領域番号: 22390372 )
  • 乳歯・永久歯由来幹細胞バンキングの有用性の検討と難治性疾患に対する再生治療研究 (研究課題/領域番号: 21390524 )
  • 乳歯・永久歯歯髄幹細胞のキャラクタライズと多角的保存再生療法へのパラダイムシフト (研究課題/領域番号: 21390507 )
  • 細胞外シグナリング受容機構と小胞体機能 (研究課題/領域番号: 18050043 )
  • 小胞体内におけるシグナリング制御機構と中枢神経組織発生 (研究課題/領域番号: 17370074 )
  • 脊椎動物体軸形成に関連した神経誘導・神経領域化の分子機構 (研究課題/領域番号: 13138204 )
  • 脊椎動物頭部形態形成の遺伝発生学的解析 (研究課題/領域番号: 08102009 )
  • 神経分化と修復におけるGM2/GD2合成酵素遺伝子の発現調節と機能 (研究課題/領域番号: 06670232 )
  • 研究者番号(50244083)による検索