徳島大学 / 教育研究者総覧 --- 大崎裕亮

個人のホームページ

https://researchmap.jp/yosaki1124 (researchmap)

https://orcid.org/0000-0001-6588-5442 (ORCID)

専門分野

○	ライフサイエンス (Life sciences) [神経内科学 (Neurology)]

研究テーマ

著書・論文

著書:

1.	沖良祐, 大崎裕亮, 和泉唯信 : F運動ニューロン疾患筋萎縮性側索硬化症(非遺伝性), 株式会社中外医学社, 2022年1月.

学術論文(審査論文):

1.	Koji Fukushima, T Yoshida, Hiroki Yamazaki, N Takamatsu, T Nagai, Yusuke Osaki, Masafumi Harada, I Nishino, N Okiyama, K Sugie and Yuishin Izumi : A Case of Anti-NXP2 Antibody-positive Juvenile Dermatomyositis with Characteristic Fascial Thickening on Muscle Ultrasound and Improvement with Immunotherapy, Internal Medicine, 2023.
2.	Kenta Hanada, Yusuke Osaki, Koji Fujita, Tatsuya Fukumoto, Koji Fukushima, Hideki Kito and Yuishin Izumi : Segmental Zoster Paresis Accompanied by Horner's Syndrome., Internal Medicine, Vol.62, No.18, 2743-2746, 2023. (要約) We herein report a 90-year-old immunocompromised woman who developed right upper limb weakness and right ptosis with a miotic pupil 1 week after oral therapy for zoster on the right T2 dermatome. The right pupil was dilated with instillation of 1% apraclonidine, indicating Horner's syndrome. The patient was treated with intravenous acyclovir and methylprednisolone. Focal weakness related to zoster, generally known as segmental zoster paresis, improved over five months, but Horner's syndrome remained. We suggest that aggressive intravenous treatment should be considered for rare cases of zoster that occur with a combination of these two neurological conditions. (キーワード) Aged, 80 and over / Female / Humans / Acyclovir / Blepharoptosis / Herpes Zoster / Horner Syndrome / Paresis (出版サイトへのリンク) ● Publication site (DOI): 10.2169/internalmedicine.0578-22 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37722924 ● Search Scopus @ Elsevier (PMID): 37722924 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.0578-22 (DOI: 10.2169/internalmedicine.0578-22, PubMed: 37722924)
3.	Shotaro Haji, Ryosuke Miyamoto, Hiroyuki Morino, Yusuke Osaki, Seijiro Tsuji, Ichizo Nishino, Masahiro Abe and Yuishin Izumi : Autosomal Recessive Spinocerebellar Ataxia Type 9 With a Response to Phosphate Repletion: A Case Report., Neurology. Genetics, Vol.9, No.3, 2023. (要約) This provides Class IV evidence. This is a single observational study without controls. (出版サイトへのリンク) ● Publication site (DOI): 10.1212/NXG.0000000000200070 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37529414 ● Search Scopus @ Elsevier (PMID): 37529414 ● Search Scopus @ Elsevier (DOI): 10.1212/NXG.0000000000200070 (DOI: 10.1212/NXG.0000000000200070, PubMed: 37529414)
4.	Takeshi Yoshida, Hiroki Yamazaki, Y Nishimori, Naoko Takamatsu, Koji Fukushima, Yusuke Osaki, Y Taniguchi, T Nozaki, Y Kumon, J Albayda, I Nishino and Yuishin Izumi : Correlation of muscle ultrasound with clinical and pathological findings in idiopathic inflammatory myopathies, Muscle & Nerve, Vol.68, No.1, 39-47, 2023. (要約) In idiopathic inflammatory myopathies (IIMs), the change in muscle echogenicity and its histopathological basis are not well understood. We quantitatively measured muscle echogenicity in patients with IIMs and evaluated its correlation with disease activity and histopathological findings. This study involved patients with IIMs who underwent both ultrasonography (US) and muscle biopsy, as well as age- and sex-matched rheumatoid arthritis patients as inflammatory disease controls. On US, axial images of the right biceps brachii and vastus medialis were obtained. Standardized histopathological scoring was used to quantitatively measure each pathological domain. Forty-two patients (17 with inclusion body myositis [IBM] and 25 with IIMs other than IBM) and 25 controls were included. The muscle echo intensity (EI) of patients with IIMs was significantly higher than that of controls. Muscle EI showed significant correlations with creatine kinase (r = 0.66, p < .001) and muscle strength (r = -0.73, p < .0001) in patients with non-IBM IIMs. In patients with IBM, moderate correlation was found between muscle EI and quadriceps muscle strength (r = -0.53, p = .028). Histopathologically, the number of infiltrating CD3+ inflammatory cells correlated with muscle EI in the non-IBM group (r = 0.56, p = .017), but not in the IBM group. Muscle EI may be useful as a surrogate marker of muscle inflammation in non-IBM IIM. Increased muscle EI may be difficult to interpret in patients with long-standing IBM, which has advanced and complex histopathology. (キーワード) Humans / Myositis / Muscle, Skeletal / Myositis, Inclusion Body / Ultrasonography / Muscle Strength (出版サイトへのリンク) ● Publication site (DOI): 10.1002/mus.27833 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37118940 ● Summary page in Scopus @ Elsevier: 2-s2.0-85158067048 (DOI: 10.1002/mus.27833, PubMed: 37118940, Elsevier: Scopus)
5.	Wataru Sako, Shotaro Haji, Takashi Abe, Yusuke Osaki, Yuki Matsumoto, Masafumi Harada and Yuishin Izumi : M1/precuneus ratio as a surrogate marker of upper motor neuron sign in ALS, Journal of the Neurological Sciences, Vol.445, 120548, 2023. (要約) To investigate whether primary motor cortex (M1) volume measured with an automated approach in MRI reflects upper motor neuron dysfunction and whether it can serve as a potential diagnostic and/or disease-tracking biomarker for amyotrophic lateral sclerosis (ALS). In this retrospective study, we enrolled 95 subjects, including 33 possible or laboratory supported probable ALS, 26 probable or definite ALS (Prob/Def), 2 primary lateral sclerosis patients, 8 progressive muscular atrophy patients, 19 normal controls (NC) and 7 ALS patients having a second structural MRI scan. Some subjects also underwent functional MRI. We calculated M1, primary sensory cortex, precuneus volumes, and total gray matter volume (TGMV) with FreeSurfer. The sensorimotor network (SMN) was identified using independent component analysis. The M1/precuneus ratio showed a significant difference between the NC and Prob/Def groups (p < 0.05). The diagnostic accuracy of the M1/precuneus ratio was moderate for distinguishing Prob/Def from NC (cutoff = 1.00, sensitivity = 0.42, specificity = 0.90). Two of eight cases without upper motor neuron dysfunction could be diagnosed with ALS using M1/precuneus ratio as a surrogate marker. A negative correlation between M1/precuneus ratio and functional activity was found in Brodmann area 6 in the SMN in all subjects. TGMV tended to decrease with disease progression (p = 0.04). The M1/precuneus volume ratio, associated with the SMN, may have potential as a surrogate biomarker of upper motor neuron dysfunction in ALS. Furthermore, TGMV may serve as an ALS disease-tracking biomarker. (キーワード) Humans / Amyotrophic Lateral Sclerosis / Retrospective Studies / Magnetic Resonance Imaging / Parietal Lobe / Motor Cortex / Biomarkers / Motor Neurons / Motor Neuron Disease (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jns.2023.120548 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36640663 ● Search Scopus @ Elsevier (PMID): 36640663 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2023.120548 (DOI: 10.1016/j.jns.2023.120548, PubMed: 36640663)
6.	Shotaro Haji, Koji Fujita, Ryosuke Oki, Yusuke Osaki, Ryosuke Miyamoto, Hiroyuki Morino, Seiichi Nagano, Naoki Atsuta, Yuki Kanazawa, Yuki Matsumoto, Atsuko Arisawa, Hisashi Kawai, Yasutaka Sato, Satoshi Sakaguchi, Kenta Yagi, Tatsuto Hamatani, Tatsuo Kagimura, Hiroaki Yanagawa, Hideki Mochizuki, Manabu Doyu, Gen Sobue, Masafumi Harada and Yuishin Izumi : An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study, JMIR Research Protocols, Vol.12, e42032, 2023. (要約) Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, with its currently approved drugs, including riluzole and edaravone, showing limited therapeutic effects. Therefore, safe and effective drugs are urgently necessary. EPI-589 is an orally available, small-molecule, novel redox-active agent characterized by highly potent protective effects against oxidative stress with high blood-brain barrier permeability. Given the apparent oxidative stress and mitochondrial dysfunction involvement in the pathogenesis of ALS, EPI-589 may hold promise as a therapeutic agent. This protocol aims to describe the design and rationale for the EPI-589 Early Phase 2 Investigator-Initiated Clinical Trial for ALS (EPIC-ALS). EPIC-ALS is an explorative, open-labeled, single-arm trial that evaluates the safety and tolerability of EPI-589 in patients with ALS. This trial consists of 12-week run-in, 24-week treatment, and 4-week follow-up periods. Patients will receive 500 mg of EPI-589 3 times daily over the 24-week treatment period. Clinical assessments include the mean monthly change of Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised total score. The biomarkers are selected to analyze the effect on oxidative stress and neuronal damage. The plasma biomarkers are 8-hydroxy-2'-deoxyguanosine (8-OHdG), 3-nitrotyrosine (3-NT), neurofilament light chain (NfL), phosphorylated neurofilament heavy chain (pNfH), homocysteine, and creatinine. The cerebrospinal fluid biomarkers are 8-OHdG, 3-NT, NfL, pNfH, and ornithine. The magnetic resonance biomarkers are fractional anisotropy in the corticospinal tract and N-acetylaspartate in the primary motor area. This trial began data collection in September 2021 and is expected to be completed in October 2023. This study can provide useful data to understand the characteristics of EPI-589. Japan Primary Registries Network jRCT2061210031; tinyurl.com/2p84emu6. DERR1-10.2196/42032. (徳島大学機関リポジトリ) ● Metadata: 118866 (出版サイトへのリンク) ● Publication site (DOI): 10.2196/42032 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36716091 ● Summary page in Scopus @ Elsevier: 2-s2.0-85149143248 (徳島大学機関リポジトリ: 118866, DOI: 10.2196/42032, PubMed: 36716091, Elsevier: Scopus)
7.	Naoko Matsui, Mika Takahara, Hiroki Yamazaki, Naoko Takamatsu, Yusuke Osaki, Ryuji Kaji, Ichizo Nishino, Satoshi Yamashita and Yuishin Izumi : A case of anti-NT5c1A antibody-seropositive inclusion body myositis associated with severe dysphagia and prominent forearm weakness, Neurology and Clinical Neuroscience, Vol.11, No.1, 46-48, 2022. (出版サイトへのリンク) ● Publication site (DOI): 10.1111/ncn3.12678 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1111/ncn3.12678 (DOI: 10.1111/ncn3.12678)
8.	Hiroki Yamazaki, Naoko Matsui, N Takamatsu, Takeshi Yoshida, Koji Fukushima, T Takata, Yusuke Osaki, K Tanaka, Y Kubo and Yuishin Izumi : Application of ultrasound in a case of eosinophilic fasciitis mimicking stiff-person syndrome, Neuromuscular Disorders, Vol.32, No.7, 590-593, 2022. (要約) Eosinophilic fasciitis (EF) is a rare disorder characterized by muscle stiffness mimicking other neuromuscular diseases. The diagnosis of EF is made on the basis of typical skin lesions. We report a case of a 36-year-old male patient with suspected stiff-person syndrome (SPS), who presented with progressive limb muscle stiffness and limited mobility of both wrists without obvious skin changes. Ultrasound revealed fascial thickening of bilateral upper and lower limb muscles and enlargement of hypoechoic tissues around the flexor digitorum tendons of the wrist. Skin and fascia biopsy confirmed the diagnosis of EF. Prednisolone therapy resulted in the improvement of muscle stiffness and tightness. Our findings suggest the need to consider connective tissue diseases such as EF in a patient with atypical features of SPS. Ultrasound is helpful for visualizing the causes of muscle stiffness and joint contractures in EF patients. (キーワード) Adult / Eosinophilia / Fasciitis / Humans / Male / Prednisolone / Stiff-Person Syndrome (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.nmd.2022.05.009 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35672204 ● Search Scopus @ Elsevier (PMID): 35672204 ● Search Scopus @ Elsevier (DOI): 10.1016/j.nmd.2022.05.009 (DOI: 10.1016/j.nmd.2022.05.009, PubMed: 35672204)
9.	Koji Fukushima, Naoko Takamatsu, Yuki Yamamoto, Hiroki Yamazaki, Takeshi Yoshida, Yusuke Osaki, Shotaro Haji, Koji Fujita, Kazuma Sugie and Yuishin Izumi : Early diagnosis of amyotrophic lateral sclerosis based on fasciculations in muscle ultrasonography: A machine learning approach., Clinical Neurophysiology, Vol.140, 136-144, 2022. (要約) We investigated 100 patients with ALS, including 50 with early-stage ALS within 9 months from onset, and 100 without ALS. Fifteen muscles were bilaterally observed for 10 s each and the presence of fasciculations was recorded. Hierarchical clustering and nominal logistic regression, neural network, or ensemble learning were applied to the training cohort comprising the early-stage ALS to develop MUS-based diagnostic models, and they were tested in the validation cohort comprising the later-stage ALS. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.clinph.2022.06.005 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35772191 ● Search Scopus @ Elsevier (PMID): 35772191 ● Search Scopus @ Elsevier (DOI): 10.1016/j.clinph.2022.06.005 (DOI: 10.1016/j.clinph.2022.06.005, PubMed: 35772191)
10.	Shotaro Haji, Wataru Sako, N Marukami, Yusuke Osaki and Yuishin Izumi : Serum NfL and CHI3L1 for ALS and parkinsonian disorders in the process of diagnosis, Journal of Neural Transmission, Vol.129, No.3, 301-309, 2022. (要約) Serum neurofilament light chain (NfL) and chitinase 3-like 1 (CHI3L1, also called YKL-40) concentrations are attractive candidate biomarkers for neurodegenerative disorders, which include amyotrophic lateral sclerosis (ALS) and parkinsonian disorders. We aimed to assess the diagnostic power of serum NfL and CHI3L1 concentrations with regard to the early diagnosis of ALS and Parkinson's disease (PD). We studied 157 individuals, which included 41 healthy controls, 8 patients with ALS mimics, 18 patients initially diagnosed with ALS (ID-ALS), 32 patients late-diagnosed with ALS (LD-ALS), 29 patients with PD, 12 patients with PD mimics, and 17 patients initially diagnosed with atypical parkinsonian disorders (ID-APDs) at the initial stage of diagnosis. Electrochemiluminescence was used to measure the concentrations of serum NfL and CHI3L1, the diagnostic performance of which was assessed using the area under the receiver operating curves (AUCs). The AUCs of serum NfL were 0.90 for discriminating ALS mimics from LD-ALS at the initial stage of diagnosis and 0.89 for discriminating ALS mimics from ALS (LD/ID-ALS). The AUCs of serum NfL were 0.76 for discriminating PD from PD mimics at the initial stage of diagnosis, and 0.80 for discriminating PD from APD. No significant difference existed in serum CHI3L1 concentrations between individuals with suspected ALS or parkinsonism (p = 0.14, and p = 0.44, respectively). Serum NfL had excellent and almost good diagnostic performances for patients with ALS and PD, respectively, at the initial stage of diagnosis, whereas no significant difference existed in serum CHI3L1 between any groups. (キーワード) Amyotrophic Lateral Sclerosis / Biomarkers / Chitinase-3-Like Protein 1 / Humans / Parkinson Disease / Parkinsonian Disorders (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00702-022-02470-z (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35178615 ● Search Scopus @ Elsevier (PMID): 35178615 ● Search Scopus @ Elsevier (DOI): 10.1007/s00702-022-02470-z (DOI: 10.1007/s00702-022-02470-z, PubMed: 35178615)
11.	大崎裕亮, 島かさ音, 山本伸昭, 山﨑博輝, 佐藤健太, 和泉唯信 : 血管炎性ニューロパチー様の臨床像で発症した抗Hu抗体陽性脳脊髄炎の1例, Peripheral Nerve, Vol.33, No.1, 136-143, 2022年.
12.	Wataru Sako, Yuishin Izumi, Takashi Abe, Shotaro Haji, Nagahisa Murakami, Yusuke Osaki, Yuki Matsumoto, Masafumi Harada and Ryuji Kaji : MR spectroscopy and imaging-derived measurements in the supplementary motor area for biomarkers of amyotrophic lateral sclerosis, Neurological Sciences, Vol.42, No.10, 4257-4263, 2021. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10072-021-05107-3 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85100872799 (DOI: 10.1007/s10072-021-05107-3, Elsevier: Scopus)
13.	Yusuke Osaki, Hiroyuki Nodera, Tatsuya Fukumoto, Ryuji Kaji and Yuishin Izumi : Peripheral nerve dysfunction in a patient with thyrotoxic periodic paralysis: Evidence from an axonal prolonged exercise test, Clinical Neurophysiology, Vol.132, No.7, 1496-1498, 2021. (キーワード) Adolescent / Adult / Axons / Exercise Test / Humans / Hypokalemic Periodic Paralysis / Male / Peripheral Nerves (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.clinph.2021.04.006 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34030052 ● Summary page in Scopus @ Elsevier: 2-s2.0-85106374066 (DOI: 10.1016/j.clinph.2021.04.006, PubMed: 34030052, Elsevier: Scopus)
14.	Wataru Sako, T Abe, Y Matsumoto, K Nakamura, Shotaro Haji, Yusuke Osaki, Masafumi Harada and Yuishin Izumi : The cerebellum is a common key for visuospatial execution and attention in Parkinson's disease, Diagnostics, Vol.11, No.6, 1042, 2021. (要約) Cognitive decline affects the clinical course in patients with Parkinson's disease (PD) and contributes to a poor prognosis. However, little is known about the underlying network-level abnormalities associated with each cognitive domain. We aimed to identify the networks related to each cognitive domain in PD using resting-state functional magnetic resonance imaging (MRI). Forty patients with PD and 15 normal controls were enrolled. All subjects underwent MRI and the Mini-Mental State Examination. Furthermore, the cognitive function of patients with PD was assessed using the Montreal Cognitive Assessment (MoCA). We used independent component analysis of the resting-state functional MRI for functional segmentation, followed by reconstruction to identify each domain-related network, to predict scores in PD using multiple regression models. Six networks were identified, as follows: the visuospatial-executive-domain-related network ( = 0.54, < 0.001), naming-domain-related network ( = 0.39, < 0.001), attention-domain-related network ( = 0.86, < 0.001), language-domain-related network ( = 0.64, < 0.001), abstraction-related network ( = 0.10, < 0.05), and orientation-domain-related network ( = 0.64, < 0.001). Cerebellar lobule VII was involved in the visuospatial-executive-domain-related and attention-domain-related networks. These two domains are involved in the first three listed nonamnestic cognitive impairment in the diagnostic criteria for PD with dementia (PDD). Furthermore, Brodmann area 10 contributed most frequently to each domain-related network. Collectively, these findings suggest that cerebellar lobule VII may play a key role in cognitive impairment in nonamnestic types of PDD. (キーワード) Parkinson's disease / cognition / functional MRI / network / cerebellum (徳島大学機関リポジトリ) ● Metadata: 116520 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/diagnostics11061042 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34204073 ● CiNii @ 国立情報学研究所 (CRID): 1050571948030401280 ● Summary page in Scopus @ Elsevier: 2-s2.0-85108274727 (徳島大学機関リポジトリ: 116520, DOI: 10.3390/diagnostics11061042, PubMed: 34204073, CiNii: 1050571948030401280, Elsevier: Scopus)
15.	Kohei Muto, Ryosuke Miyamoto, Yuka Terasawa, Yoshimitsu Shimatani, Keijiro Hara, Takumi Kakimoto, Tatsuya Fukumoto, Yusuke Osaki, Koji Fujita, Masafumi Harada, Hisanori Uehara, Yasushi Takagi and Yuishin Izumi : A novel COL4A1 variant associated with recurrent epistaxis and glioblastoma, Human Genome Variation, Vol.8, No.1, 18, 2021. (徳島大学機関リポジトリ) ● Metadata: 116530 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41439-021-00150-0 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85105944271 (徳島大学機関リポジトリ: 116530, DOI: 10.1038/s41439-021-00150-0, Elsevier: Scopus)
16.	Shotaro Haji, Wataru Sako, Nagahisa Murakami, Yusuke Osaki, Takahiro Furukawa, Yuishin Izumi and Ryuji Kaji : The value of serum uric acid as a prognostic biomarker in amyotrophic lateral sclerosis: Evidence from a meta-analysis, Clinical Neurology and Neurosurgery, Vol.203, 106566, 2021. (徳島大学機関リポジトリ) ● Metadata: 116650 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.clineuro.2021.106566 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.clineuro.2021.106566 (徳島大学機関リポジトリ: 116650, DOI: 10.1016/j.clineuro.2021.106566)
17.	Yusuke Osaki, Wataru Sako, Masafumi Harada and Yuishin Izumi : Magnetic resonance tractography exhibiting retrograde degeneration of the corticospinal tract in a patient with a unilateral spinal cord tumor, Brain and Behavior, Vol.11, No.4, e02020, 2021. (徳島大学機関リポジトリ) ● Metadata: 116501 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/brb3.2020 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1002/brb3.2020 (徳島大学機関リポジトリ: 116501, DOI: 10.1002/brb3.2020)
18.	CT Suratos, N Takamatsu, Hiroki Yamazaki, Yusuke Osaki, T Fukumoto, Hiroyuki Nodera and Yuishin Izumi : Utility of phrenic nerve ultrasound in amyotrophic lateral sclerosis, Acta Neurologica Belgica, Vol.121, No.1, 225-230, 2021. (徳島大学機関リポジトリ) ● Metadata: 116266 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s13760-020-01531-y (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85094859144 (徳島大学機関リポジトリ: 116266, DOI: 10.1007/s13760-020-01531-y, Elsevier: Scopus)
19.	高松直子, 大崎裕亮, 山﨑博輝, 黒田一駿, 小川博久, 上原久典, 常山幸一, 野寺裕之, 和泉唯信 : 腕神経叢エコー検査が契機となって悪性腫瘍が診断できた1例, 神経超音波医学, Vol.33, No.2, 36-40, 2020年. (要約) A 72-year-old man admitted to our hospital due to severe pain and drop hand in the left arm. MRI and CT of the head and neck at an outside hospital showed no abnormality. Neurological findings revealed distal weakness in the left upper extremity, vague pain between the radial aspect of the left hand and the middle of the digits 1-3, as well as brisk reflexes in the left extremities. Small masses were palpable in the posterior neck, the lower jaw, and the left neck. Clinically, left radial neuropathy and cervical radiculopathy were suspected. We performed ultrasound of the nerve roots, brachial plexus, and the radial nerve. There was a mass compressing the left brachial plexus from the caudolateral direction. Additionally, nerve swelling in the left arm was identified. Skin biopsy over the mass suggested metastatic adenocarcinoma. Chest CT scan showed a mass in the upper right lobe suggestive of a lung cancer. We concluded that the pain was due to radial neuropathy and upper and middle trunk disturbance of the left brachial plexopathy, of which neuromuscular ultrasound was useful in diagnosis. (キーワード) upper limb pain / brachial plexus ultrasound / metastasis (出版サイトへのリンク) ● Publication site (DOI): 10.2301/neurosonology.33.36 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390567172576336384 ● Search Scopus @ Elsevier (DOI): 10.2301/neurosonology.33.36 (DOI: 10.2301/neurosonology.33.36, CiNii: 1390567172576336384)
20.	Wataru Sako, Takashi Abe, Shotaroh Haji, Nagahisa Murakami, Yusuke Osaki, Yuishin Izumi, Masafumi Harada and Ryuji Kaji : A method for differential diagnosis of parkinsonian syndromes, Acta Neurologica Scandinavica, Vol.140, No.3, 229-235, 2019. (要約) Neurological findings are important for the differential diagnosis of Parkinson's disease (PD), multiple system atrophy with predominant parkinsonian features (MSA-P), and progressive supranuclear palsy (PSP). There is currently no fast and reliable method to distinguish these patients. To address this, we propose a novel approach to measure midbrain and pons size using a longitudinal "one line" method from the mid-sagittal view. Structural images were acquired from 101 subjects who underwent 3.0 T MRI (20 controls, 44 PD, 20 MSA, 12 PSP, and 5 corticobasal syndrome). We measured the middle cerebellar peduncle (MCP), superior cerebellar peduncle (SCP), midbrain, and pons. Brainstem size was measured by area or length of the longitudinal axis, which we named the "one line" method. We conducted intraclass correlation coefficients to assess the extent of agreement and consistency among raters, and receiver operating characteristic curves were used to determine diagnostic accuracy. Intraclass correlation coefficients (ICC) of MCP width were excellent in sagittal and axial sections while those of SCP width were moderate. There were also excellent ICCs between raters for "one line" method of the midbrain and pons, while areas showed good ICCs. "One line" method and area of the midbrain were better than SCP width for the differential diagnosis of PSP from MSA-P and PD. In contrast, there was no clearly superior measurement for differentially diagnosing MSA-P. The "one line" method was comparable with area for inter-rater agreement and diagnostic accuracy even though this was a simple and fast way. (キーワード) Aged / Diagnosis, Differential / Female / Humans / Magnetic Resonance Imaging / Male / Mesencephalon / Middle Aged / Multiple System Atrophy / Parkinsonian Disorders / Pons / Supranuclear Palsy, Progressive (出版サイトへのリンク) ● Publication site (DOI): 10.1111/ane.13136 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31225648 ● Summary page in Scopus @ Elsevier: 2-s2.0-85067842485 (DOI: 10.1111/ane.13136, PubMed: 31225648, Elsevier: Scopus)
21.	Toshitaka Kawarai, Hiroki Yamazaki, Ryosuke Miyamoto, Naoko Takamatsu, Atsuko Mori, Yusuke Osaki, Antonio Orlacchio, Hiroyuki Nodera, Akihiro Hashiguchi, Yujiro Higuchi, Akiko Yoshimura, Hiroshi Takashima and Ryuji Kaji : PMP22-related disease: A novel splice site acceptor variant and intrafamilial phenotype variability., Neuromuscular Disorders, Vol.26, No.6, 422-426, 2019. (要約) PMP22 is the most frequent mutated gene in Charcot-Marie-Tooth disease (CMT) type 1A. Another phenotype, hereditary neuropathy with pressure palsies (HNPP), could be caused by PMP22 mutations. PMP22 encodes a peripheral myelin protein with molecular weight 22-kDa. Various pathomechanisms have been postulated in PMP22-related disease, including dysfunction due to missense mutations, and alteration of a gene dose due to duplication/deletion mutations. We identified a novel PMP22 splice site acceptor variant, c.179-1G>A, in a patient with adult-onset chronic generalized polyneuropathy and two asymptomatic family members. Pathophysiological features of the members mainly overlapped with those reported in HNPP, but broad intrafamilial clinical variations were observed. PMP22 transcripts lacking of exon 4 were produced by the variant, presumably leading to in-frame deletion of 47 amino acids. The variant was also shown to exert effect on dosage of PMP22 mRNA. The complex molecular pathology would lead to the unique clinical and pathophysiological conditions. (キーワード) Adult / 家族 (family) / 女性 (female) / Gene Dosage / Hereditary Sensory and Motor Neuropathy / Humans / 男性 (male) / Middle Aged / Mutation / Myelin Proteins / Pedigree / Phenotype / Polyneuropathies / RNA Splice Sites (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.nmd.2019.03.010 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31122831 ● Summary page in Scopus @ Elsevier: 2-s2.0-85065707113 (DOI: 10.1016/j.nmd.2019.03.010, PubMed: 31122831, Elsevier: Scopus)
22.	Naoko Matsui, Hiroyuki Nodera, D Kuzume, N Iwasa, Y Unai, W Sakai, Y Miyazaki, H Yamazaki, Yusuke Osaki, A Mori, T Furukawa, A Tsukamoto-Miyashiro, Y Shimatani, M Yamasaki, Yuishin Izumi, S Kusunoki, Kokichi Arisawa and Ryuji Kaji : Guillan-Barre syndrome in local area in Japan, 2006-2015: an epidemiological and clinical study of 108 patients, European Journal of Neurology, Vol.25, No.5, 718-724, 2018. (要約) Many epidemiological studies of Guillain-Barré syndrome (GBS) and Fisher syndrome (FS) have been conducted in Europe and America. In contrast, epidemiological studies are rare in Asia where the GBS subtypes differ from those in Western countries. This study was undertaken to clarify the incidence of GBS and FS in a local area in Japan as well as their seasonal trends. Seventy-one GBS and 37 FS patients were recorded from 2006 to 2015 in an area of approximately 1.5 million inhabitants in Japan. The incidence, seasonal trends and clinical features of GBS and FS were examined. The incidence rate of GBS was 0.42 cases per 100 000 person-years and that of FS was 0.22 cases per 100 000 person-years. The incidence of GBS increased with age and FS affected predominantly patients aged from 45 to 64 years old. There was some seasonal clustering of acute motor axonal neuropathy (AMAN) and FS in spring and summer, but it was not significant. AMAN and FS patients had a high frequency of preceding infection (AMAN, 68% gastrointestinal infection; FS, 65% upper respiratory infection). Antecedent respiratory infection was significantly associated with FS as an outcome. Serum antibodies to ganglioside GM1 were detected in 71% of AMAN patients and antibodies to GQ1b were detected in 81% of FS patients. Our study offers evidence of a lower incidence of GBS and a higher incidence of FS in a local area in Japan than in Western countries. (出版サイトへのリンク) ● Publication site (DOI): 10.1111/ene.13569 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29337417 ● Summary page in Scopus @ Elsevier: 2-s2.0-85042582939 (DOI: 10.1111/ene.13569, PubMed: 29337417, Elsevier: Scopus)
23.	山上圭, 古川貴大, 大崎裕亮, 村上永尚, 中道一生, 西條政幸, 松井尚子, 和泉唯信, 梶龍兒 : 未治療のサルコイドーシスに合併した進行性多巣性白質脳症, 神経感染症, Vol.23, No.1, 151-156, 2018年.
24.	Koji Fujita, Yusuke Osaki, Ryosuke Miyamoto, Shimatani Yoshimitsu, Takashi Abe and Shimatani Yoshimitsu : Neurologic attack and dynamic perfusion abnormality in neuronal intranuclear inclusion disease, Neurology. Clinical Practice, Vol.7, No.6, e39-e42, 2017. (出版サイトへのリンク) ● Publication site (DOI): 10.1212/CPJ.0000000000000389 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29431160 ● Search Scopus @ Elsevier (PMID): 29431160 ● Search Scopus @ Elsevier (DOI): 10.1212/CPJ.0000000000000389 (DOI: 10.1212/CPJ.0000000000000389, PubMed: 29431160)

総説・解説:

1.	大崎裕亮, 和泉唯信 : ニューロパチーからみたRFC1遺伝子関連スペクトラム障害, 脳と神経, Vol.74, No.11, 1281-1286, 2022年.
2.	大崎裕亮, 和泉唯信 : ALSの診断基準:Awaji基準までの変遷を中心に, 難病と在宅ケア, Vol.27, No.3, 40-44, 2021年6月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523669555953827840 (CiNii: 1523669555953827840)
3.	大崎裕亮, 高松直子, 和泉唯信 : 筋電図検査における検査技師の役割は何か(医師の立場から), 臨床神経生理学, Vol.49, No.2, 85-88, 2021年4月. (要約) <p>筋電図検査は患者個別に最適化を要し, その最適化には検査特性や神経筋疾患の病態に関する専門的知識が求められる．筋電図検査が神経筋疾患の診療に有効であるためには, 少なくとも専門知識を持った監督者が検査実施現場に配置される必要がある．その監督業務を担うための技能取得が, 今後ますます検査技師に求められていく可能性がある．厚生労働省はタスク・シフティング等医療勤務環境改善推進事業において, 検査業務を医師から技師に移していく方針を掲げているためである．本稿では, 筋電図検査における検査技師の役割は何かという問いに対して本学会内での議論を活発化させることを目的として, 筋電図検査実施体制について当院での体制を例示し, 現状とタスク・シフトが求められている時流を踏まえた理想像について述べる．</p> (出版サイトへのリンク) ● Publication site (DOI): 10.11422/jscn.49.85 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390006076308478976 ● Search Scopus @ Elsevier (DOI): 10.11422/jscn.49.85 (DOI: 10.11422/jscn.49.85, CiNii: 1390006076308478976)

国際会議:

1.	Yusuke Osaki, Hiroyuki Nodera, Ryosuke Miyamoto, Hiroyuki Morino, M Chan, Ryuji Kaji and Yuishin Izumi : Peripheral nerve excitability abnormality in spinocerebellar ataxia type 6, Neuroscience 2023, Nov. 2023.
2.	Shotaro Haji, R Oki, Koji Fujita, Yusuke Osaki, S Nagano, N Atsuta, Y Kanazawa, Y Matsumoto, A Arisawa, H Kawai, Y Sato, S Sakaguchi, K Yaki, T Hamatani, Hiroaki Yanagawa, Masafumi Harada, G Sobue and Yuishin Izumi : EPI-589 early phase 2 investigator-initiated clinical trial for ALS (EPIC-ALS): protocol for an exploratory study, Pan-Asia Consortium for Treatment and Research in ALS (PACTALS) 2021 NAGOYA, Nagoya, Sep. 2021.
3.	Hiroki Yamazaki, N Takamatsu, Koji Fukushima, Takeshi Yoshida, Yusuke Osaki and Yuishin Izumi : Application of nerve ultrasound for early diagnosis of ALS focus on brachial plexus, Pan-Asia Consortium for Treatment and Research in ALS (PACTALS) 2021 NAGOYA, Nagoya, Sep. 2021.
4.	Koji Fukushima, N Takamatsu, Hiroki Yamazaki, Yusuke Osaki, Takeshi Yoshida, K Sugie and Yuishin Izumi : The specificity of faciculations in brainstem and thoracic region detected by muscle ultrasonography in ALS, A comparative muscle ultrasonographic investigation of 100 ALS patients and 100 non-ALS patients, Pan-Asia Consortium for Treatment and Research in ALS (PACTALS) 2021 NAGOYA, Nagoya, Sep. 2021.

国内講演発表:

1.	土師正太郎, 佐光亘, 村上永尚, 大崎裕亮, 和泉唯信 : メタ解析から見えるパーキンソン病のプラセボ効果の要因, 第53回日本神経精神薬理学会年会, 2023年9月.
2.	土師正太郎, 佐光亘, 福島功士, 花田健太, 大崎裕亮, 松元友暉, 原田雅史, 和泉唯信 : QSMを用いた視床下核の面先・磁化率評価は進行性核上性麻痺の診断に有用である, 第64回日本神経学会学術大会, 2023年6月.
3.	山﨑博輝, 髙松直子, 福島功士, 花田健太, 大崎裕亮, 和泉唯信 : 発症早期ALSの診断における神経超音波を用いた脳神経叢評価の有用性, 第64回日本神経学会学術大会, 2023年5月.
4.	山﨑博輝, 髙松直子, 大崎裕亮, 和泉唯信 : どこまで追うべき!? 神経超音波によるuncommon nerveの描出の有用性, 第64回日本神経学会学術大会, 2023年5月.
5.	山上圭, 花田健太, 山本雄貴, 山﨑博輝, 大崎裕亮, 松井尚子, 藤田浩司, 和泉唯信 : 尿閉・便秘を呈したフィッシャー症候群の34歳男性例, 第112回日本神経学会中国・四国地方会, 2022年12月.
6.	花田健太, 大崎裕亮, 宮本亮介, 土師正太郎, 森野豊之, 和泉唯信 : 新規のMORC2変異を認めたCharcot-Marie-Tooth病2Z型の1例, 第112回日本神経学会中国・四国地方会, 2022年12月.
7.	佐光亘, 土師正太郎, 阿部考志, 大崎裕亮, 松本友暉, 原田雅史, 和泉唯信 : 運動ニューロン疾患の一次運動野の容積と感覚運動ネットワークの活動性との関連, 日本臨床神経生理学会第52回学術大会, 2022年11月.
8.	谷美紀, 大崎裕亮, 山﨑博輝, 福島功士, 和泉唯信 : 3回目の筋電図検査で診断に至った抗MuSK抗体陽性重症筋無力症の一例, 日本臨床神経生理学会第52回学術大会, 2022年11月.
9.	花田健太, 山﨑博輝, 高松直子, 大崎裕亮, 和泉唯信 : 神経超音波検査で評価したneurolymphomatosisの1例,, 日本臨床神経生理学会第52回学術大会, 2022年11月.
10.	大崎裕亮, 野寺裕之, 山﨑博輝, 高松直子, 梶龍兒, 和泉唯信 : 誤診から学ぶ筋電図検査筋電図検査前の診断が困難な神経筋疾患同疾患3症例の提示, 日本臨床神経生理学会第52回学術大会, 2022年11月.
11.	大崎裕亮, 野寺裕之, 山﨑博輝, 和泉唯信 : 神経筋疾患の問題症例下肢近位筋・遠位筋筋力低下を来した脱髄性多発ニューロパチーの一例, 日本臨床神経生理学会第52回学術大会, 2022年11月.
12.	松井尚子, 山﨑博輝, 高松直子, 吉田剛, 福島功士, 高田忠幸, 大崎裕亮, 田中惠子, 久保宣明, 和泉唯信 : Stiff-person症候群との鑑別に筋超音波検査が有用であった好酸球性筋膜炎の一例,, 日本臨床神経生理学会第52回学術大会, 2022年11月.
13.	松井尚子, 山﨑博輝, 高松直子, 吉田剛, 福島功士, 高田忠幸, 大崎裕亮, 田中惠子, 久保宣明, 和泉唯信 : Stiff-person症候群との鑑別に筋超音波検査が有用であった好酸球性筋膜炎の一例, 第34回日本神経免疫学会学術集会, 2022年10月.
14.	花田健太, 大崎裕亮, 宮本亮介, 土師正太郎, 森野豊之, 和泉唯信 : MORC2新規変異を認めたCharcot-Marie-Tooth病2Z型の1例, 第33回日本末梢神経学会学術集会, 2022年9月.
15.	花田健太, 山本雄貴, 大崎裕亮, 島かさ音, 武藤浩平, 宮本亮介, 藤田浩司, 和泉唯信 : Ocular flutterと体幹優位の運動失調を認めた抗NMDA受容体抗体陽性の若年女性例, 第111回日本神経学会中国・四国地方会, 2022年6月.
16.	花田健太, 山本雄貴, 大崎裕亮, 島かさ音, 武藤浩平, 宮本亮介, 藤田浩司, 和泉唯信 : Ocular flutterと体幹優位の運動失調を認めた抗NMDA受容体抗体陽性の若年女性例, 第63回日本神経学会学術大会, 2022年5月.
17.	山﨑博輝, 高松直子, 福島功士, 吉田剛, 大崎裕亮, 和泉唯信 : 脱髄性ニューロパチーの補助診断における神経超音波を用いた腕神経叢評価の有用性, 第63回日本神経学会学術大会, 2022年5月.
18.	福島功士, 高松直子, 山本雄貴, 山﨑博輝, 吉田剛, 土師正太郎, 大崎裕亮, 藤田浩司, 杉江和馬, 和泉唯信 : 筋超音波検査の線維束性収縮に基づく筋萎縮性側索硬化症の診断マーカー, 第63回日本神経学会学術大会, 2022年5月.
19.	大崎裕亮, 宮本亮介, 森野豊之, 和泉唯信 : Distal hereditary motor neuropathyを呈したMARS新規変異を有する1家系, 第63回日本神経学会学術大会, 2022年5月.
20.	土師正太郎, 藤田浩司, 沖良祐, 大崎裕亮, 金澤裕樹, 松元友暉, 有澤亜津子, 川井恒, 佐藤康敬, 八木健太, 坂口暁, 楊河宏章, 濱谷辰斗, 長野清一, 望月秀樹, 熱田直樹, 道勇学, 祖父江元, 原田雅史, 和泉唯信 : EPI-589の筋萎縮性側索硬化症を対象とした探索的医師主導試験(EPIC-ALS), 第63回日本神経学会学術大会, 2022年5月.
21.	花田健太, 大崎裕亮, 和泉唯信 : 筋萎縮性側索硬化症の発症年齢はどう変化しているか, 第33回日本老年医学会四国地方会, 2022年1月.
22.	大崎裕亮 : CIDP鑑別診断の要点, 第51回日本臨床神経生理学会学術大会ランチョンセミナー2, 2021年12月.
23.	大崎裕亮, 島かさ音, 山本伸昭, 山﨑博輝, 佐藤健太, 和泉唯信 : 非対称性ニューロパチー様の臨床像で発症した抗Hu抗体陽性脳脊髄炎の一例, 第32回日本末梢神経学会学術集会, 2021年9月.
24.	松原知康, 和泉唯信, 土師正太郎, 山﨑博輝, 大崎裕亮, 宮本亮介, 藤田浩司, 齋藤祐子, 村山繁雄 : Lewy小体型認知症と筋萎縮性側索硬化症を合併した1例, 第62回日本神経病理学会総会学術研究会, 2021年5月.
25.	島かさ音, 藤田浩司, 大崎裕亮, 和泉唯信 : 中枢神経ゴム腫で発症した梅毒の 1 例, 第124回日本内科学会四国地方会, 2021年5月.
26.	花田健太, 大崎裕亮, 島かさ音, 武藤浩平, 福本竜也, 山本雄貴, 鬼頭秀樹, 和泉唯信 : 病院連携により病理解剖を行った筋萎縮性側索硬化症の1例, 第108回日本神経学会中国・四国地方会, 2020年12月.
27.	花田健太, 大崎裕亮, 福本竜也, 松井尚子, 和泉唯信, 浦岡秀行 : 初期に頭部画像病変を欠くCISが先行し，10年後に診断された多発性硬化症の一例, 第61回日本神経学会学術大会, 2020年8月.
28.	大崎裕亮, 佐光亘, 土師正太郎, 村上永尚, 松井尚子, 和泉唯信 : 傍腫瘍性視神経脊髄炎関連疾患(NMOSD)の高齢男性例, 第61回日本神経学会学術大会, 2020年8月.
29.	宮本亮介, 黒田一駿, 牟礼英生, 森垣龍馬, 中瀧理仁, 大崎裕亮, 和泉唯信, 後藤惠, 梶龍兒 : 18p-症候群に伴う全身性ジストニアに対し，GPi-DBSが効果的であった一例, 第61回日本神経学会学術大会, 2020年8月.
30.	山﨑博輝, 高松直子, 福島功士, 三宅晶子, 垂髪祐樹, 吉田剛, 大崎裕亮, 森敦子, 野寺裕之, 和泉唯信 : 手指の痺れを主訴とした患者に対しどこまで対応するか, 第38回日本脳神経超音波学会総会, 2019年6月.
31.	大崎裕亮 : 神経核内封入体病の末梢神経興奮特性, 第60回日本神経学会学術大会, 2019年5月.
32.	原田紗希, 近藤真代, 西村春佳, 内藤伸仁, 河野弘, 大崎裕亮, 坂東良美, 髙橋直希, 香川耕造, 西岡安彦, 荻野広和, 飛梅亮, 西條敦郎, 軒原浩, 豊田優子, 吾妻雅彦, 後東久嗣, 上原久典, 西岡安彦 : 傍腫瘍性神経症候群を合併した小細胞肺癌の一例, 第60回日本呼吸器学会中国・四国地方会, 2018年12月.
33.	福本竜也, 宮本亮介, 山﨑博輝, 村上永尚, 大崎裕亮, 藤田浩司, 野寺裕之, 瓦井俊孝, 和泉唯信, 梶龍兒 : 特異な歩行障害を呈したGerstmann-Straussler-Scheinker病の31歳男性, 第105回日本神経学会中国・四国地方会, 2018年12月.
34.	高松直子, 野寺裕之, 瓦井俊孝, 山崎博輝, 森敦子, 大崎裕亮, 垂髪祐樹, 和泉唯信, 梶龍兒 : -PMP221, 第48回日本臨床神経生理学会学術大会, 2018年11月.
35.	山上紘規, 吉田守美子, 遠藤ふうり, 原倫世, 筒井康継, 桝田志保, 倉橋清衛, 明比祐子, 遠藤逸朗, 粟飯原賢一, 大崎裕亮, 梶龍兒, 髙士祐一, 安倍正博, 福本誠二 : 壊死性ミオパチーを合併したX連鎖性低リン血症性くる病・骨軟化症の一例, 第18回日本内分泌学会四国支部学術集会, 2018年9月.
36.	Hanada Kenta, Naoko Matsui, Hiroyuki Nodera, Kuzume Daisuke, Kenta Sato, Iwasa Naoki, Unai Yuki, Saka Waka, Yoshimichi Miyazaki, Yamazaki Hiroki, Yusuke Osaki, Takahiro Furukawa, Yamasaki Masahiro, Yuishin Izumi, Kusunoki Susumu, Kokichi Arisawa and Ryuji Kaji : Guillain-Barre syndrome in a local area in Japan, 2006-2015: An epidemiological and clinical study of 108 patients, XX World Congress of Neurology, Sep. 2017.

その他・研究会:

1.	松井尚子, 大崎裕亮, 西野一三, 山下賢, 和泉唯信 : 封入体筋炎における抗NT5C1A抗体と臨床像:当院症例について, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(令和元年度) 東北大学医学部星陵会館大会議室, 2020年1月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

光コヒーレンストモグラフィを用いた新しい神経筋画像検査の確立 (研究課題/領域番号: 25670421 )
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助教 : 大崎裕亮

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

助教 : 大崎裕亮