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Tokushima UniversityGraduate School of Biomedical Sciences医学域先端医学教育研究プロジェクト
Tokushima UniversityGraduate School of Biomedical Sciences医学域Medical SciencePathological SciencesDepartment of Pathology and Laboratory Medicine
Tokushima UniversityFaculty of MedicineSchool of MedicineCourse of Bioregulation and Medical OncologyPathology and Laboratory Medicine
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Research

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Field of Study

Pathology
Allergology
Nutrition

Subject of Study

NASH線維化の病態解明と治療法の確立 (NASHモデル, 肝線維化モデル, 高脂肪コレステロール食, macrophage)
- (epicutaneous sensitization, food allergy, 甲殻類アレルギー, Tropmyosin, model animal of food allergy by epicutaneous sensitization, deep sea water, 職業性食物アレルギー)

Book / Paper

Book:

1. Mayuko Shimizu, Nakanishi Atsuko, Kitagishi Yasuko and Matsuda Satoru :
Function of the RUN Domain on RUFY Family Proteins,
Springer, Jun. 2018.
2. Akari Minami, Toshiyuki Murai, Atsuko Nakanishi, Yasuko Kitagishi, Mayuko Shimizu and Satoru Matsuda :
Cell cycle regulation via the p53, PTEN, and BRCA1 tumor suppressors,
InTech, 2016.

Academic Paper (Judged Full Paper):

1. Mayuko Shimizu, Soichiroh Ishimaru, Wai Yee Yan Christine, Takeo Minamikawa, Takaaki Tsunematsu, Aiko Endoh, Takumi Kojima, Minoru Matsumoto, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, MIYAGAMI Yuko, Hirohisa Ogawa, Takeshi Oya and Koichi Tsuneyama :
Establishment of an epicutaneously sensitized murine model of shellfish allergy and evaluation of skin condition by Raman microscopy.,
Applied Sciences, Vol.12, No.3566, 2022.
(Tokushima University Institutional Repository: 117211,   DOI: 10.3390/app12073566)
2. Hirohisa Ogawa, Masahiko Azuma, Aya Umeno, Mayuko Shimizu, Kazutoshi Murotomi, Yasukazu Yoshida, Yasuhiko Nishioka and Koichi Tsuneyama :
Singlet oxygen -derived nerve growth factor exacerbates airway hyperresponsiveness in a mouse model of asthma with mixed inflammation.,
Allergology International, Vol.71, No.3, 395-404, 2022.
(Tokushima University Institutional Repository: 117273,   DOI: 10.1016/j.alit.2022.02.005,   PubMed: 35346582)
3. Takeo Minamikawa, Eiji Hase, Mayuko Shimizu, Yuki Morimoto, Akihiro Suzuki, Takeshi Yasui, Satoko Nakamura, Akemi Tsutsui, Koichi Takaguchi and Koichi Tsuneyama :
Assessment of Ultra-Early-Stage Liver Fibrosis in Human Non-Alcoholic Fatty Liver Disease by Second-Harmonic Generation Microscopy.,
International Journal of Molecular Sciences, Vol.23, No.6, 3357, 2022.
(Tokushima University Institutional Repository: 117221,   DOI: 10.3390/ijms23063357,   PubMed: 35328778,   Elsevier: Scopus)
4. Mayuko Shimizu, Yosuke Tsuchiyama, Yuki Morimoto, Minoru Matsumoto, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, Takeshi Oya, Hirohisa Ogawa, Michiko Yamashita, Satoru Matsuda, Katsuhisa Omagari, Shu Taira and Koichi Tsuneyama :
A novel mouse model of non-alcoholic steatohepatitis suggests that liver fibrosis initiates around lipid-laden macrophages,
The American Journal of Pathology, Vol.192, No.1, 31-42, 2022.
(Tokushima University Institutional Repository: 116411,   DOI: 10.1016/j.ajpath.2021.10.002,   PubMed: 34710382)
5. Mayuko Shimizu, Takeshi Kageyama, Takeshi Oya, Hirohisa Ogawa, Minoru Matsumoto, Satoshi Sumida, Takumi Kakimoto, Yuko Miyakami, Ryosuke Nagatomo, Koichi Inoue, Chunmei Cheng and Koichi Tsuneyama :
Verification of the Impact of Blood Glucose Level on Liver Carcinogenesis and the Efficacy of a Dietary Intervention in a Spontaneous Metabolic Syndrome Model,
International Journal of Molecular Sciences, Vol.22, No.23, 12844, 2021.
(Tokushima University Institutional Repository: 116736,   DOI: 10.3390/ijms222312844,   PubMed: 34884650)
6. Tomoko Kobayashi, Mayuko Shimizu, Takeshi Oya, Hirohisa Ogawa, Minoru Matsumoto, Yuki Morimoto, Satoshi Sumida, Takumi Kakimoto, Michiko Yamashita, Mitsuko Sutoh, Shunji Toyohara, Ryoji Hokao, Chunmei Cheng and Koichi Tsuneyama :
Neonatal streptozotocin treatment rapidly causes different subtype of hepatocellular carcinoma without persistent hyperglycemia in 4CS mice fed on a normal diet.,
Pathology, Research and Practice, Vol.225, No.153559, 2021.
(DOI: 10.1016/j.prp.2021.153559,   PubMed: 34325313)
7. Yuki Morimoto, Takeshi Oya, Mayuko Shimizu, Minoru Matsumoto, Hirohisa Ogawa, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, Michiko Yamashita, Chunmei Cheng and Koichi Tsuneyama :
Applying Probe Electrospray Ionization Mass Spectrometry to Cytological Diagnosis: A Preliminary Study by Using Cultured Lung Cancer Cells.,
Acta Cytologica, Vol.65, No.5, 430-439, 2021.
(Tokushima University Institutional Repository: 116345,   DOI: 10.1159/000516639,   PubMed: 34098551)
8. Mayuko Shimizu, Katsuhisa Omagari, Michiko Yamashita and Koichi Tsuneyama :
Development of a novel mouse model of diet-induced nonalcoholic steatohepatitis-related progressive bridging fibrosis.,
Bioscience, Biotechnology, and Biochemistry, Vol.85, No.4, 941-947, 2021.
(DOI: 10.1093/bbb/zbaa107,   PubMed: 33620426)
9. Takeo Minamikawa, Mayuko Shimizu, Hiroki Takanari, Yuki Morimoto, Ryosuke Shiomi, Tanioka Hiroki, Eiji Hase, Takeshi Yasui and Koichi Tsuneyama :
Molecular imaging analysis of microvesicular and macrovesicular lipid droplets in non-alcoholic fatty liver disease by Raman microscopy.,
Scientific Reports, Vol.10, No.1, 18548, 2020.
(Tokushima University Institutional Repository: 115619,   DOI: 10.1038/s41598-020-75604-6,   PubMed: 33122711)
10. Omagari Katsuhisa, Suzuta Masako, Taniguchi Asami, Kuramoto Risa, Koyama Yuko, Suruga Kazuhito, Mayuko Shimizu and Koichi Tsuneyama :
A non-obese, diet-induced animal model of nonalcoholic steatohepatitis in Wistar/ST rats compared to Sprague-Dawley rats,
Clinical Nutrition Experimental, Vol.30, 1-14, 2020.
(Tokushima University Institutional Repository: 116726,   DOI: 10.1016/j.yclnex.2020.03.001,   Elsevier: Scopus)
11. Atsuko Takai, Kentaro Kikuchi, Mayuko Shimizu, Koichi Tsuneyama, Yuki Moritoki, Kotaro Matsumoto, Hiromichi Tsunashima, Takeshi Onda, Noriyuki Kuniyoshi, Tomoyuki Nariyama, Sho Ohyatsu, Juri Kubota, Kozue Nagumo, Shinpei Sato, Masumi Hara and Hiroshi Miyakawa :
Fructo-oligosaccharides ameliorate steatohepatitis, visceral adiposity, and associated chronic inflammation via increased production of short-chain fatty acids in a mouse model of non-alcoholic steatohepatitis.,
BMC Gastroenterology, Vol.20, No.1, 46, 2020.
(Tokushima University Institutional Repository: 114532,   DOI: 10.1186/s12876-020-01194-2,   PubMed: 32103741,   Elsevier: Scopus)
12. Kanehiko Suwa, Takashi Yamaguchi, Katsunori Yoshida, Miki Murata, Mayuko Shimizu, Koichi Tsuneyama, Toshihito Seki and Kazuichi Okazaki :
Smad Phospho-Isoforms for Hepatocellular Carcinoma Risk Assessment in Patients with Nonalcoholic Steatohepatitis.,
Cancers, Vol.12, No.2, 286, 2020.
(Tokushima University Institutional Repository: 115043,   DOI: 10.3390/cancers12020286,   PubMed: 31991602,   Elsevier: Scopus)
13. Ayumi Fukuda, Marin Sasao, Eri Asakawa, Sumire Narita, Mei Hisano, Kazuhito Suruga, Mayuko Shimizu, Koichi Tsuneyama, Kazunari Tanaka and Katsuhisa Omagari :
Dietary fat, cholesterol, and cholic acid affect the histopathologic severity of nonalcoholic steatohepatitis in Sprague-Dawley rats,
Pathology, Research and Practice, Vol.215, No.11, 152599, 2019.
(DOI: 10.1016/j.prp.2019.152599,   PubMed: 31564568,   Elsevier: Scopus)
14. Katsuhisa Omagari, Eri Asakawa, Marin Sasao, Sumire Narita, Mei Hisano, Ayumi Fukuda, Kazuhiro Suruga, Mayuko Shimizu and Koichi Tsuneyama :
Age-related alterations of nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet.,
Journal of Nutritional Science and Vitaminology, Vol.65, No.4, 349-356, 2019.
(DOI: 10.3177/jnsv.65.349,   PubMed: 31474685,   Elsevier: Scopus)
15. Ayaka Iida, Sachi Kuranuki, Ryoko Yamamoto, Masaya Uchida, Masanori Ohta, Mayuko Shimizu, Koichi Tsuneyama, Takayuki Masaki, Masataka Seike and Tsuyoshi Nakamura :
Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice.,
Experimental Animals, Vol.68, No.4, 417-428, 2019.
(Tokushima University Institutional Repository: 115102,   DOI: 10.1538/expanim.18-0152,   PubMed: 31155606)
16. Katsuhisa Omagari, Ayumi Fukuda, Machiko Suga, Ayumi Ogata, Shinta Nishioka, Kazuhito Suruga, Mayuko Shimizu and Koichi Tsuneyama :
Peptides Obtained by Enzymatic Decomposition of Mackerel Prevent Nonalcoholic Steatohepatitis in Sprague-Dawley Rats fed a High-fat and High-cholesterol Diet,
OBM Hepatology and Gastroenterology, Vol.2, No.3, 2018.
(DOI: 10.21926/obm.hg.1803008)
17. Ryosuke Nagatomo, Yasuki Okada, Mayuko Shimizu, Koichi Tsuneyama and Koichi Inoue :
Application of 2-Picolylamine Derivatized Ultra-high Performance Liquid Chromatography Tandem Mass Spectrometry for Determination of Short-chain Fatty Acids in Feces Samples.,
Analytical Sciences, Vol.34, No.9, 1031-1036, 2018.
(DOI: 10.2116/analsci.18SCP10,   PubMed: 30078818)
18. Katsuhisa Omagari, Kazuhito Suruga, Akira Kyogoku, Satomi Nakamura, Ai Sakamoto, Shinta Nishioka, Mayuko Shimizu, Yuji Miyata, Koichi Tajima, Koichi Tsuneyama and Kazunari Tanaka :
A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet.,
Hepatobiliary Surgery and Nutrition, Vol.7, No.3, 175-184, 2017.
(DOI: 10.21037/hbsn.2017.08.03,   PubMed: 30046568)
19. Kotaro Matsumoto, Mayuko Shimizu, Koichi Tsuneyama, Yuki Moritoki, Hiromichi Tsunashima, Katsuhisa Omagari, Masumi Hara, Ichiro Yasuda, Hiroshi Miyakawa and Kentaro Kikuchi :
Fructo-oligosaccharides and intestinal barrier function in a methionine-choline-deficient mouse model of nonalcoholic steatohepatitis.,
PLoS ONE, Vol.12, No.6, e0175406, 2017.
(Tokushima University Institutional Repository: 112342,   DOI: 10.1371/journal.pone.0175406,   PubMed: 28632732)
20. Mayuko Shimizu, Miki Masuzumi, Miku Kawase, Mika Sakaki, Shizuka Tamaru, Yasuo Nagata, Kazunari Tanaka, Kazuhito Suruga, Koichi Tsuneyama, Satoru Matsuda and Katsuhisa Omagari :
A diet-induced Sprague-Dawley rat model of nonalcoholic steatohepatitis-related cirrhosis.,
The Journal of Nutritional Biochemistry, Vol.40, 62-69, 2017.
(DOI: 10.1016/j.jnutbio.2016.10.007,   PubMed: 27863346)
21. Katsuhisa Omagari, Mika Sakaki, Yuki Tsujimoto, Yukiko Shiogama, Akiko Iwanaga, Makiko Ishimoto, Asami Yamaguchi, Miki Masuzumi, Miku Kawase, Mayuko Shimizu, Takatoshi Yoshitake and Yoshiyuki Miyahara :
Coffee consumption is inversely associated with depressive status in Japanese patients with type 2 diabetes.,
Journal of Clinical Biochemistry and Nutrition, Vol.55, No.2, 135-142, 2014.
(DOI: 10.3164/jcbn.14-30,   PubMed: 25320461)
22. Mayuko Shimizu, Miku Kawase, Miki Masuzumi, Mika Sakaki, Yasuo Nagata, Kazunari Tanaka, Kazuhito Suruga, Shizuka Tamaru, Shigeko Kato, Koichi Tsuneyama and Katsuhisa Omagari :
High-fat and high-cholesterol diet rapidly induces non-alcoholic steatohepatitis with advanced fibrosis in Sprague-Dawley rats.,
Hepatology Research, Vol.45, No.4, 458-469, 2014.
(DOI: 10.1111/hepr.12358,   PubMed: 24827559)
23. Katsuhisa Omagari, Chisato Yoshikawa, Shin-ichi Inoue, Yuna Tanaka, Toshie Murayama, Mayuko Shimizu, Ayako Miyata, Sawako Mori, Mai Kamogawa, Eri Hirao, Shigeko Kato, Kazuhito Suruga and Koichi Tsuneyama :
Abdominal subcutaneous adipose tissue accumulation is positively correlated with hepatic steatosis in Sprague-Dawley rats,
Acta Medica Nagasakiensia, Vol.59, No.2, 47-56, 2014.
(DOI: 10.11343/amn.59.47,   CiNii: 1390001204675540224,   Elsevier: Scopus)
24. Mayuko Shimizu, Shigeko Kato, Koichi Tsuneyama, Sachiko Matsutake, Mai Kamogawa, Eri Hirao, Ayako Miyata, Sawako Mori, Noriaki Yamaguchi, Kazuhito Suruga and Katsuhisa Omagari :
Phycocyanin prevents hypertension and low serum adiponectin level in a rat model of metabolic syndrome.,
Nutrition Research, Vol.33, No.5, 397-405, 2013.
(DOI: 10.1016/j.nutres.2013.03.006,   PubMed: 23684441)
25. 松竹 幸子, 大曲 勝久, 加藤 滋子, Mayuko Shimizu, 石井 由夏, 加地 真奈美, 岩見 春香, 市川 辰樹 and 中尾 一彦 :
C型慢性肝炎に対する抗ウィルス療法の治療効果に及ぼす栄養状態の影響,
Journal of Japanese Society of Clinical Nutrition, Vol.35, 39-48, 2013.
(CiNii: 1571980076086901760)
26. Katsuhisa Omagari, Toshie Murayama, Yuna Tanaka, Chisato Yoshikawa, Shin-ichi Inoue, Mayuko Shimizu, Maiko Hatanaka, Mari Saimei, Keiko Muto, Takuro Tobina, Motofumi Masaki and Shigeko Kato :
Mental, physical, dietary, and nutritional effects on irritable bowel syndrome in young Japanese women.,
Internal Medicine, Vol.52, No.12, 1295-1301, 2013.
(DOI: 10.2169/internalmedicine.52.0248,   PubMed: 23774537)
27. Katsuhisa Omagari, Rika Takamura, Sachiko Matsutake, Mayuko Shimizu, Shigeko Kato, Shun-Ichi Morikawa, Seiko Nagaoka and Masayuki Osabe :
Serum alanine aminotransferase concentration as a predictive factor for the development or regression of fatty liver.,
Journal of Clinical Biochemistry and Nutrition, Vol.49, No.3, 200-206, 2011.
(DOI: 10.3164/jcbn.11-27,   PubMed: 22128220)

Academic Paper (Unrefereed Paper):

1. 福田 歩美, 駿河 和仁, 古場 一哲, Mayuko Shimizu, Koichi Tsuneyama and 大曲 勝久 :
非アルコール性脂肪肝炎モデルラットにおける NAFLD activity scoreとFLIPアルゴリズムによる 組織学的評価の比較検討,
長崎県立大学看護栄養学部紀要, Vol.20, 121-128, 2022.
(CiNii: 1050010610491153920)
2. 中野 紀子, 南 明里, Mayuko Shimizu and 松田 覚 :
A Report on the Collaboration Project Between Nara Prefecture and Nara Women's University Called "Nara Nutrition College",
教育システム研究, Vol.12, 91-98, 2017.
(CiNii: 1050282813368708480)
3. Katsuhisa Omagari, Haruna Torii, Shiho Goto, Ai Sakamoto, Miki Hattori, Toshie Murayama-Kinjo, Mayuko Shimizu, Kenichi Tanabe and Sachiko Matsumoto :
Dietary intake, mental status, physical activity, and lifestyle affecting bowel movement frequency and stool texture in young Japanese women,
Acta Medica Nagasakiensia, Vol.60, 85-95, 2016.
(DOI: 10.11343/amn.60.85,   Elsevier: Scopus)
4. 大曲 勝久, 服部 美紀, 後藤 紫方, 坂元 藍, 鳥居 春菜, Mayuko Shimizu and 田辺 賢一 :
非アルコール性脂肪肝炎発症モデルラットの肝組織所見に及ぼす食餌性コレステロールの影響,
長崎県立大学看護栄養学部紀要, Vol.14, 23-30, 2016.
(CiNii: 1050564287381690496)
5. Katsuhisa Omagari, Haruka Iwami, Manami Kaji, Yuka Ishii, Sachiko Matsutake, Mayuko Shimizu, Shigeko Kato, Shigeyuki Takeshita, Tatsuki Ichikawa and Kazuhiko Nakao :
The relationship between energy expenditure and type or stage of cancer,
Acta Medica Nagasakiensia, Vol.57, No.2, 33-40, 2012.
(DOI: 10.11343/amn.57.33,   Elsevier: Scopus)
6. Katsuhisa Omagari, Manami Kaji, Yuka Ishii, Haruka Iwami, Mayuko Shimizu, Sachiko Matsutake, Shigeko Kato, Shigeyuki Takeshita, Tatsuki Ichikawa and Kazuhiko Nakao :
Protein-energy malnutrition in patients with liver cirrhosis,
Acta Medica Nagasakiensia, Vol.57, 5-12, 2012.
(Elsevier: Scopus)
7. Katsuhisa Omagari, Shigeko Kato, Koichi Tsuneyama, Hideki Hatta, Mayuko Shimizu, Chisato Urata, Yasuko Sumiyama, Ayako Nishizaki, Sakiko Hashimoto, Mai Harada, Shizuka Tamaru and Kazunari Tanaka :
The Effect of Olive Leaf Extract on Hepatic Fat Accumulation in Sprague- Dawley Rats Fed a High-fat Diet,
Acta Medica Nagasakiensia, Vol.55, No.1, 29-39, 2010.
(DOI: 10.11343/amn.55.29,   Elsevier: Scopus)

Academic Letter:

1. Mayuko Shimizu, Maiko Hatanaka, Koichi Tsuneyama, Shigeko Kato and Katsuhisa Omagari :
An SHR/NDmcr-cp rat model of non-alcoholic steatohepatitis with advanced fibrosis induced by a high-fat, high-cholesterol diet.,
J Obes Wt Loss Ther, Vol.5, 1, 2015.

Review, Commentary:

1. 菊池 健太郎, 松本 光太郎, 高井 敦子, Mayuko Shimizu, 守時 由起, Koichi Tsuneyama, 原 眞純 and 宮川 浩 :
Gastrointestinal microbiome and non-alcoholic steatohepatitis,
Diabetology, Endocrinology & Metabolology, Vol.53, No.3, 356-360, Sep. 2021.
(CiNii: 1571136036586657792)
2. Mayuko Shimizu :
非アルコール性脂肪肝炎および脳機能障害における脂質の挙動,
アグリバイオ, Vol.5, No.6, 521-525, Jun. 2021.
(CiNii: 1572543411523172992)
3. Koichi Tsuneyama, Mayuko Shimizu, Takeshi Oya, Minoru Matsumoto, Tomoko Kobayashi, Hirohisa Ogawa, Kazuchika Nishitsuji and Michiko Yamashita :
肝臓病理所見のとり方とその解釈,
法医病理, Vol.25, No.1, 1-12, Jul. 2019.
4. Akari Minami, Mako Ogino, Noriko Nakano, Mayuko Shimizu, Atsuko Nakanishi, Toshiyuki Murai, Yasuko Kitagishi and Satoru Matsuda :
Roles of oncogenes and tumor-suppressor genes in osteoclastogenesis (Review).,
International Journal of Molecular Medicine, Vol.39, No.2, 261-267, Jan. 2017.
(DOI: 10.3892/ijmm.2017.2847,   PubMed: 28075460)
5. Noriko Nakano, Satoru Matsuda, Mayuko Shimizu, Akari Minami, Mako Ogino, Toshiyuki Murai and Yasuko Kitagishi :
PI3K/AKT signaling mediated by G protein-coupled receptors is involved in neurodegenerative Parkinson's disease (Review).,
International Journal of Molecular Medicine, Vol.39, No.2, 253-260, Dec. 2016.
(DOI: 10.3892/ijmm.2016.2833,   PubMed: 28000847)
6. Yasuko Kitagishi, Noriko Nakano, Mako Ogino, Mayuko Shimizu, Akari Minami and Satoru Matsuda :
PINK1 signaling in mitochondrial homeostasis and in aging (Review).,
International Journal of Molecular Medicine, Vol.39, No.1, 3-8, Dec. 2016.
(DOI: 10.3892/ijmm.2016.2827,   PubMed: 27959386)
7. Satoru Matsuda, Mayuko Shimizu, Mako Ogino, Noriko Nakano, Akari Minami, Toshiyuki Murai and Yasuko Kitagishi :
Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review).,
International Journal of Oncology, Vol.49, No.5, 1785-1790, Sep. 2016.
(DOI: 10.3892/ijo.2016.3710,   PubMed: 27826621)
8. Mako Ogino, Mayuko Shimizu, Noriko Nakano, Akari Minami, Yasuko Kitagishi and Satoru Matsuda :
Roles of PTEN with DNA Repair in Parkinson's Disease.,
International Journal of Molecular Sciences, Vol.17, No.6, Jun. 2016.
(Tokushima University Institutional Repository: 115630,   DOI: 10.3390/ijms17060954,   PubMed: 27314344)
9. Mayuko Shimizu, Akari Minami, Noriko Nakano, Yasuko Kitagishi, Toshiyuki Murai and Satoru Matsuda :
Cigarette smoke may be an exacerbation factor in nonalcoholic fatty liver disease via the modulation for PI3K/AKT pathway,
AIMS Molecular Science, Vol.2, 427-439, 2015.

Proceeding of International Conference:

1. Kikuchi Kentaro, Matsumoto Kotaro, Takai Atsuko, Mayuko Shimizu, Moritoki Yuki, Koichi Tsuneyama and Hara Masumi :
Fructo-oligosaccharides ameliorate steatohepatitis via increased production of short-chain fatty acids in mice,
JSH International Liver Conference 2021, Oct. 2021.
2. Mayuko Shimizu, 富永 俊弼 and Koichi Tsuneyama :
A novel image analysis technology that can verify quantification and progress pattern of NASH fibrosis,
The Liver Meeting 2020, Boston, Nov. 2020.
3. Mayuko Shimizu and Koichi Tsuneyama :
Phellodendron bark and its component berberine prevent nonalcoholic steatohepatitis-related fibrosis in mice,
29th Asian Pacific Association for the Study of the Liver (APASL) 2020, Bali, Mar. 2020.
4. Eiji Hase, Hiroki Takanari, Mayuko Shimizu, Hayashi Yuri, Takeo Minamikawa, Takeshi Yasui and Koichi Tsuneyama :
Characterization of fibrosis in non-alcoholic steatohepatitis by use of second-harmonic-generation microscopy,
Asian Pacific Association for the Study of the Liver 2020 (APASL 2020), Bali, Indonesia, Mar. 2020.
5. Takeo Minamikawa, Mayuko Shimizu, Hiroki Takanari, Shiomi Ryosuke, Kusaka Hiroki, Tanioka Hiroki, Eiji Hase, Takeshi Yasui and Koichi Tsuneyama :
Molecular imaging analysis of accumulated fats in non-alcoholic steatohepatitis by Raman microscopy,
Asian Pacific Association for the Study of the Liver 2020 (APASL 2020), Bali, Indonesia, Mar. 2020.
6. Mayuko Shimizu and Koichi Tsuneyama :
Fibrosis begins around lipid-phagocytic macrophages in high fat/cholesterol/cholate diet-induced nonalcoholic steatohepatitis model,
The Liver Meeting 2019, Boston, Nov. 2019.
7. Mayuko Shimizu, Hirohisa Ogawa, Minoru Matsumoto and Koichi Tsuneyama :
Establishment of a novel dietary-induced mouse model showing steatohepatitis with severe fibrosis,
UEG Week 2019, Barcelona, Oct. 2019.
8. Mayuko Shimizu, Takeshi Oya and Koichi Tsuneyama :
Fibrogenesis of nonalcoholic steatohepatitis begins around cholesterol-laden macrophage in the experimental mouse model,
UEG Week 2019, Barcelona, Oct. 2019.
9. Ayumi Sugitani, Mayuko Shimizu, Shu Taira, Takaaki Tsunematsu and Koichi Tsuneyama :
Analysis of fibrogenic roles of liver infiltrating macrophages in a novel Non-alcoholic steatohepatitis (NASH) rat model with liver cirrhosis,
Hepatology, Vol.66, No.S1, 1099A-1100A, Oct. 2017.
10. Mayuko Shimizu, Kawase Miku, Masuzumi Miki, Sakaki Mika, Nagata Yasuo, Tanaka Kazunari, Suruga Kazuhito, Koichi Tsuneyama and Omagari Katsuhisa :
High-fat and high-cholesterol diet rapidly induces nonalcoholic steatohepatitis with advanced fibrosis in Sprague-Dawley rats,
23th Asian Pacific Association for the Study of the Liver, Mar. 2014.

Proceeding of Domestic Conference:

1. Honoka Nakahara, Asuka Watanabe, Mayuko Shimizu, Hirohisa Ogawa and Koichi Tsuneyama :
Inhibitory effects of berberine on liver fibrosis in NASH model mice,
第111回日本病理学会総会, Apr. 2022.
2. Soichiroh Ishimaru, Mayuko Shimizu, Hirohisa Ogawa and Koichi Tsuneyama :
An Application of Raman Microscopy to Analyzing Dermal Changes in Cutaneously Sensitized Food Allergy Mice,
第111回日本病理学会総会, Apr. 2022.
3. Minoru Matsumoto, Yasuyo Saijo, Mayuko Shimizu, Hirohisa Ogawa, Koichi Tsuneyama, Mitsuru Matsumoto and Takeshi Oya :
胸腺癌におけるAIRE発現と胸腺髄質上皮細胞との類似性,
Proceedings of the Japanese Society of Pathology, Vol.111, No.1, 243, Apr. 2022.
4. Mayuko Shimizu :
新規 brain-liver axis モデルの報告:うつ病マウスにおける脂肪肝炎,
COI学術交流会, Feb. 2022.
5. 長友 涼介, Mayuko Shimizu, Koichi Tsuneyama and 井之上 浩一 :
2-ピコリルアミン誘導体化LC-MS/MS法を用いた病態モデルマウス体液及び組織中短鎖脂肪酸の分析法開発,
第32回クロマトグラフィー科学会議, Nov. 2021.
6. 柿本 拓海, Mayuko Shimizu, Hirohisa Ogawa, Minoru Matsumoto, Takeshi Oya and Koichi Tsuneyama :
Validation of α -synuclein immunohistochemical staining in the diagnosis of non-alcoholic steatohepatitis,
The 67th Autumn Annual Meeting of Japanese Society of Pathology, Nov. 2021.
7. Takeo Minamikawa, Mayuko Shimizu, Hiroki Tanioka, Eiji Hase, Yuki Morimoto, Hiroki Takanari, Takeshi Yasui and Koichi Tsuneyama :
ラマン散乱分光法を用いた 非アルコール性脂肪性肝疾患の脂質分子構造イメージング解析,
レーザ顕微鏡研究会第46回講演会, Nov. 2021.
8. Mayuko Shimizu, 遠藤 亜衣子, 石丸 漱一郎 and Koichi Tsuneyama :
経皮感作によるエビアレルギーモデルマウスの確立と予防法の検討,
第54回 日本栄養・食糧学会 中国・四国支部大会 第7回 日本栄養改善学会 四国支部学術総会合同大会, Oct. 2021.
9. Hiroki Tanioka, Takeo Minamikawa, Mayuko Shimizu, Yuki Morimoto, Hiroki Takanari, Yutaro Onishi, Eiji Hase, Takeshi Yasui and Koichi Tsuneyama :
表面増強ラマン散乱分光法を用いた非アルコール性脂肪肝疾患モデルの高感度ラマンイメージング,
第82回応用物理学会秋季学術講演会予稿集, 13a-N202-9, Sep. 2021.
10. Kensei Nishida, Mayuko Shimizu, Masahiko Azuma, Koichi Tsuneyama and Masashi Akaike :
オンラインPBLチュートリアルの実施から見えてきた課題,
第53回日本医学教育学会大会, Jul. 2021.
11. 長友 涼介, Mayuko Shimizu, Koichi Tsuneyama, Naozumi Ishimaru and 井之上 浩一 :
誘導体化LC-MS/MSによる網羅的短鎖脂肪酸解析: モデルマウス病態への応用,
第 6 回日本医用マススペクトル学会西部会, Jul. 2021.
12. Takeo Minamikawa, Mayuko Shimizu and Koichi Tsuneyama :
Molecular structural imaging analysis for non-alcoholic fatty liver disease by Raman spectroscopy,
The 57th Annual Meeting of the Japan Society of Hepatology, Jun. 2021.
13. Katsuki Miyazaki, Yu Saitou, Mayuko Shimizu, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Koichi Tsuneyama and Mitsuo Shimada :
小胞体ストレス応答に着目した非アルコール性脂肪肝炎の肝切除後肝再生/肝不全に関する研究,
第47回日本急性肝不全研究会, Jun. 2021.
14. Katsuki Miyazaki, Yu Saitou, Mayuko Shimizu, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shin-ichiro Yamada, Kazunori Tokuda, Koichi Tsuneyama and Mitsuo Shimada :
Endoplasmic reticulum stress response deficiency is a major cause of poor liver regeneration after hepatectomy in nonalcoholic steatohepatitis,
第33回日本肝胆膵外科学会学術集会, Jun. 2021.
15. Mayuko Shimizu, 富永 俊弼 and 筒井 朱美 :
NASH線維化の連続的数値による定量的評価のための新規画像解析法の開発,
第57回日本肝臓学会総会, Jun. 2021.
16. Mayuko Shimizu, 平 修, Hirohisa Ogawa and Koichi Tsuneyama :
Phospholipids Imaging of the Liver and Brain in a Mouse Model of Nonalcoholic Steatohepatitis,
第69回質量分析総合討論会2021, May 2021.
17. Mayuko Shimizu, 遠藤 亜衣子, 石丸 漱一郎, 小島 拓海, Hirohisa Ogawa and Koichi Tsuneyama :
Epicutaneous sensitization conditions for food allergens in animal models,
第110回日本病理学会総会, Apr. 2021.
18. 住田 智志, Mayuko Shimizu, 西條 康代, Minoru Matsumoto, Hirohisa Ogawa, Takeshi Oya, Yoshimi Bando, Hisanori Uehara and Koichi Tsuneyama :
Pathological features and pathogenesis of epidermoid cyst in intrapancreatic accessory spleen,
第110回日本病理学会総会, Apr. 2021.
19. Katsuki Miyazaki, Yu Saitou, Mayuko Shimizu, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shin-ichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita, Koichi Tsuneyama and Mitsuo Shimada :

非アルコール性脂肪性肝疾患(NAFLD)における肝切除後肝再生機能不全に関する研究- 小胞体ストレス応答不全の観点より -, Apr. 2021.
20. Mayuko Shimizu, 富永 俊弼 and 筒井 朱美 :
NASH線維化の連続的数値による定量的評価のための新規画像解析法の開発,
Acta Hepatologica Japonica, Vol.62, No.suppl.1, A132, Mar. 2021.
21. Kensei Nishida, Mayuko Shimizu, Koichi Tsuneyama and Masashi Akaike :
オンラインPBLチュートリアルの実施報告ならびにその効果と課題,
大学教育カンファレンスin徳島, Jan. 2021.
22. 長友 涼介, 福田 敦子, Mayuko Shimizu, Koichi Tsuneyama and 井之上 浩一 :
実験計画法を用いた高感度2-ピコリルアミン 誘導体化UHPLC-ESI-MS/MS法の開発: 血中短鎖脂肪酸測定への応用,
第31回クロマトグラフィー科学会議, Nov. 2020.
23. Mayuko Shimizu, 大曲 勝久 and Koichi Tsuneyama :
実験的モデル動物作成に用いられる高脂肪・コレステロール食に含まれるコール酸のNASH病態形成への影響,
第56回日本肝臓学会総会, Aug. 2020.
24. Mayuko Shimizu :
Make a food-based healthy body to counter the unprecedented crisis,
第3回COI学術交流会, Jul. 2020.
25. Mayuko Shimizu, 平 修, Minoru Matsumoto, Takeshi Oya, Hirohisa Ogawa and Koichi Tsuneyama :
イメージング質量分析によるNASH線維化肝で増加する脂質の同定,
第109回日本病理学会総会, Jul. 2020.
26. Mayuko Shimizu, Riku Yamaguchi, CHIYAMOTO Mana, OSAKI Yui and Koichi Tsuneyama :
Antibacterial agent for external use promotes epicutaneous sensitization of food allergen in experimental mice,
第74回日本栄養食糧学会大会, May 2020.
27. Mayuko Shimizu, 平 修, Minoru Matsumoto, Takeshi Oya, Hirohisa Ogawa and Koichi Tsuneyama :
NASH線維化肝におけるpathogen lipidsの同定,
第260回徳島医学会学術集会, Feb. 2020.
28. Koichi Tsuneyama, Mayuko Shimizu, Takeshi Oya, Minoru Matsumoto and Hirohisa Ogawa :
自然発症メタボリックシンドローム-NASH-HCCモデルマウスにおけるプレバイオティクスによる腸内細菌叢への介入効果の検討,
第30回日本消化器癌発生学会総会, Nov. 2019.
29. Mayuko Shimizu, 大曲 勝久 and Koichi Tsuneyama :
食餌摂取による高度な線維化を伴うNASHモデルマウスの開発,
第55回日本肝臓学会総会, May 2019.
30. Koichi Tsuneyama and Mayuko Shimizu :
免疫チェックポイント阻害薬による肝障害を来した4例の病理学的特徴,
第55回日本肝臓学会総会, May 2019.
31. 飯田 綾香, 甲斐 瑠衣子, 倉貫 早智, Mayuko Shimizu, Koichi Tsuneyama and 中村 強 :
Nonalcoholic fatty liver Disease in Western Diet-Loaded C57BL/6J mice,
第73回日本栄養食糧学会大会, May 2019.
32. 福田 歩美, 佐々尾 真鈴, 浅川 惠理, 成田 純令, 久野 萌偉, 駿河 和仁, Mayuko Shimizu, Koichi Tsuneyama, 田中 一成 and 大曲 勝久 :
Incidence of non-alcoholic steatohepatitis in SD rats fed a high-fat and high-cholesterol diet.,
第73回日本栄養食糧学会大会, May 2019.
33. Mayuko Shimizu, 大曲 勝久 and Koichi Tsuneyama :
Establishment of dietary model of nonalcoholic steatohepatitis-related fibrosis,
第73回日本栄養食糧学会大会, May 2019.
34. Mayuko Shimizu, Takeshi Oya, Hirohisa Ogawa, 大曲 勝久 and Koichi Tsuneyama :
Cholesterol-loaded macrophage is associated with development of hepatic fibrosis in mice,
第108回日本病理学会総会, May 2019.
35. 長友 涼介, 福田 敦子, Mayuko Shimizu, 赤津 裕康, Koichi Tsuneyama and 井之上 浩一 :
2-ピコリルアミン誘導体化UHPLC-ESI-MS/MS法を用いた短鎖脂肪酸のマウス臓器分布解析,
日本薬学会第139年会, Mar. 2019.
36. Koichi Tsuneyama, Mayuko Shimizu, Takeshi Oya, Minoru Matsumoto and Hirohisa Ogawa :
異なる系統で作成したストレプトゾトシン誘導肝細胞癌モデルマウスの病態比較,
第29回日本消化器癌発生学会総会, Nov. 2018.
37. 天野 久実, 中川 友希江, Mayuko Shimizu, 辻 愛, 北岸 靖子 and 松田 覚 :
オウバク成分は非アルコール性脂肪肝疾患(NAFLD)改善に関与するか?,
第91回日本生化学会大会, Sep. 2018.
38. 中川 友希江, 天野 久実, Mayuko Shimizu, 辻 愛, 北岸 靖子 and 松田 覚 :
脂肪性肝障害に対する少量アセトアルデヒド摂取の影響,
第91回日本生化学会大会, Sep. 2018.
39. Mayuko Shimizu, Kazuchika Nishitsuji, 清水 金忠, Hirohisa Ogawa, Takaaki Tsunematsu, 梅本 ひとみ, 森本 友樹, 赤津 裕康, 井之上 浩一 and Koichi Tsuneyama :
TSODマウスにおけるNAFLDの発症およびコーヒーの投与による腸内細菌叢および短鎖脂肪酸プロファイルの変化,
第5回肝臓と糖尿病・代謝研究会, Jul. 2018.
40. Mayuko Shimizu, 大曲 勝久 and Koichi Tsuneyama :
The morphological changes of the liver of TSOD and TSNO mice fed the high-fat plus cholesterol diet,
第107回日本病理学会総会, Jun. 2018.
41. 井邉 有未, Mayuko Shimizu and 松田 覚 :
小学校低学年とその保護者を対象とした食育活動,
第64回日本栄養改善学会学術総会, Sep. 2017.
42. Mayuko Shimizu, 井邉 有未 and 松田 覚 :
親子で学ぶ食育教室の意義 ―奈良県地域栄養カレッジにおける実践例から―,
第64回日本栄養改善学会学術総会, Sep. 2017.
43. Mayuko Shimizu and 松田 覚 :
地域住民向け食育活動『奈良県地域栄養カレッジ』実施報告,
奈良県栄養士会 研究発表会, Aug. 2017.
44. 中村 禎子, 田辺 賢一, Mayuko Shimizu, 森田 茂樹, 大曲 勝久 and 奥 恒行 :
過剰鉄による肝障害モデルラットにおけるフラクトオリゴ糖摂取の症状軽減作用,
日本栄養食糧学会, May 2017.
45. Mayuko Shimizu, Koichi Tsuneyama, 守時 由起, 松本 光太郎, 綱島 弘道, 大曲 勝久 and 菊池 健太郎 :
異なる非アルコール性脂肪肝炎モデル間におけるフラクトオリゴ糖による肝脂肪化抑制機序の違い,
Acta Hepatologica Japonica, Vol.58, No.Suppl.1, A395, Apr. 2017.
46. 菊池 健太郎, Koichi Tsuneyama, Mayuko Shimizu, 守時 由起, 松本 光太郎, 綱島 弘道, 大曲 勝久, 安田 一朗, 原 眞純 and 宮川 浩 :
monosodium glutamate投与によるNASHモデルマウスに対するフラクトオリゴ糖の効果,
Acta Hepatologica Japonica, Vol.58, No.Suppl.1, A388, Apr. 2017.
47. Koichi Tsuneyama, Mayuko Shimizu and 大曲 勝久 :
食餌誘導NASH 肝線維化モデルラットにおける肝浸潤マクロファージの性状,
Acta Hepatologica Japonica, Vol.58, No.Suppl.1, A396, Apr. 2017.
48. Ayumi Sugitani, Ryusei Takahashi, Kohki Kai, Mayuko Shimizu, 平 修, 川口 誠, Hirohisa Ogawa, Takaaki Tsunematsu, Koichi Tsuneyama, 野本 一博 and Koichi Tsuneyama :
A case of lipid-rich carcinoma of the breast with numerous hyaline globules,
Proceedings of the Japanese Society of Pathology, Vol.106, No.1, 492-493, Mar. 2017.
49. 杉谷 鮎美, 高橋 立成, 甲斐 幸樹, Mayuko Shimizu, 平 修, 川口 誠, Hirohisa Ogawa, Takaaki Tsunematsu, Koichi Tsuneyama, 野本 一博 and 常山 幸一 :
A case of lipid-rich carcinoma of the breast with numerous hyaline globules(和訳中),
Proceedings of the Japanese Society of Pathology, Vol.106, No.1, 492-493, Mar. 2017.
50. 南 明里, 中野 紀子, Mayuko Shimizu and 松田 覚 :
Effect of food ingredients on osteoclast differentiation,
第70回日本栄養食糧学会大会, May 2016.
51. 西明 眞理, 幸田 菜摘, 矢野 詩織, Mayuko Shimizu, 川本 忠文 and 片山 吉穂 :
The effect of diallyl sulfide(DAS) on body conposition and energy metabolism in rats.,
第67回日本栄養食糧学会大会, May 2013.
52. Mayuko Shimizu, 畑中 麻衣子, Koichi Tsuneyama, 加藤 滋子 and 大曲 勝久 :
An animal model of NASH with advanced fibrosis induced by high-fat and high-cholesterol diet,
第67回日本栄養食糧学会大会, May 2013.

Et cetera, Workshop:

1. Kohta Hata, Ryoga Yuasa, TAKEUCHI Sarina, Michiko Yamashita, Takeshi Oya, Koichi Tsuneyama and Mayuko Shimizu :
骨髄膠様変性時,臨床検査値と造血幹細胞ニッチはどう変化しているか,
THE TOKUSHIMA JOURNAL OF MEDICAL TECHNOLOGY, 28, Dec. 2021.
2. 小林 由利恵, 竹内 紗里奈, Michiko Yamashita, Koichi Tsuneyama and Mayuko Shimizu :
骨髄膠様変性と相関する臨床検査値の統計学的研究,
THE TOKUSHIMA JOURNAL OF MEDICAL TECHNOLOGY, 19, Dec. 2020.
3. Mayuko Shimizu :
コレステロール添加高脂肪飼料を用いたNASH病態モデル動物の開発,
奈良女子大学家政学会, Vol.62, 57-61, 2015.

Patent:

1. Mayuko Shimizu, Koichi Tsuneyama and 大曲 勝久 : 肝の線維化を伴い得るNAFLDモデル動物,その作製方法,及びそれを作製するための飼料, (Oct. 2017), .

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Elucidation of the pathogenesis and new therapeutic strategies for brain- and gut-related steatohepatitis based on brain-derived neurotrophic factor (Project/Area Number: 22K07024 )
  • The role of macrophages in the progression of fibrosis of NASH and its regulation by nutritional factors (Project/Area Number: 20K19676 )
  • Search for functional ingredients and foods altering cholesterol-bile acid metabolism for prevention of NASH development (Project/Area Number: 17K17883 )
  • Search by Researcher Number (20759021)