Tokushima University / Educator and Researcher Directory --- Shiozaki, Yuji

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Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 医学域 ⟩ 先端栄養学教育研究プロジェクト ⟩
Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 医学域 ⟩ Medical Nutrition ⟩ Medical Nutrition ⟩ Department of Applied Nutrition ⟩

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Research

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Sumire Sasaki, Megumi Koike, Kazuya Tanifuji, Minori Uga, Kota Kawahara, Aoi Komiya, Mizuki Miura, Yamato Harada, Yuki Hamaguchi, Shohei Sasaki, Yuji Shiozaki, Ichiro Kaneko, Ken-ichi Miyamoto and Hiroko Segawa : Dietary polyphosphate has a greater effect on renal damage and FGF23 secretion than dietary monophosphate, The Journal of Medical Investigation : JMI, Vol.69, No.3, 173-179, 2022. (Summary) Phosphate (Pi)-containing food additives are used in several forms. Polyphosphate (PPi) salt has more harmful effects than monophosphate (MPi) salt on bone physiology and renal function. This study aimed to analyze the levels of parathyroid hormone PTH and fibroblast growth factor 23 (FGF23) and the expression of renal / intestinal Pi transport-related molecules in mice fed with an MPi or PPi diet. There were no significant differences in plasma Pi concentration and fecal Pi excretion levels between mice fed with the high-MPi and PPi diet. However, more severe tubular dilatation, interstitial fibrosis, and calcification were observed in the kidneys of mice fed with the high PPi diet versus the MPi diet. Furthermore, there was a significant increase in serum FGF23 levels and a decrease in renal phosphate transporter protein expression in mice fed with the PPi diet versus the MPi diet. Furthermore, the high MPi diet was associated with significantly suppressed expression and activity of intestinal alkaline phosphatase protein. In summary, PPi has a more severe effect on renal damage than MPi, as well as induces more FGF23 secretion. Excess FGF23 may be more involved in inflammation, fibrosis, and calcification in the kidney. J. Med. Invest. 69 : 173-179, August, 2022. (Keyword) Animals / Mice / Alkaline Phosphatase / Diet / Fibroblast Growth Factors / Fibrosis / Food Additives / Kidney / Parathyroid Hormone / Phosphate Transport Proteins / Phosphates / Polyphosphates (Tokushima University Institutional Repository) ● Metadata: 117148 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.69.173 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244766 ● Summary page in Scopus @ Elsevier: 2-s2.0-85139886601 (Tokushima University Institutional Repository: 117148, DOI: 10.2152/jmi.69.173, PubMed: 36244766, Elsevier: Scopus)

Academic Paper (Unrefereed Paper):

1.	Hiroko Segawa, 小池萌, Yuji Shiozaki and Ken-ichi Miyamoto : 抗老化因子を制御するミネラル栄養学-リン代謝恒常制御の重要性, 実験医学増刊∼栄養・代謝物シグナルと食品機能∼, Vol.40, No.7, 2022.
2.	Masashi Masuda, Yuji Shiozaki, Yutaka Taketani and 宮崎淳 : 最前線慢性腎臓病の合併症とlipotoxicity, Farumashia, Vol.58, No.4, 329-333, 2022. (Link to Publication Site) ● Publication site (DOI): 10.14894/faruawpsj.58.4_329 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.14894/faruawpsj.58.4_329 (DOI: 10.14894/faruawpsj.58.4_329)
3.	谷藤和也, Yuji Shiozaki and Hiroko Segawa : 骨を維持する栄養素, Journal of Health, Physical Education and Recreation, Vol.71, No.11, 801-806, 2021. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520572360407947392 (CiNii: 1520572360407947392)
4.	金子一郎, 宇賀穂, Yuji Shiozaki, Ken-ichi Miyamoto and Hiroko Segawa : The physiological function of vitamin D which maintains phosphate homeostasis, ビタミン, Vol.95, No.56, 280-285, 2021. (Summary) Inorganic phosphate (Pi) plays essential roles in many biological processes. Blood Pi level should be maintained at a constant range because hypophosphatemia causes rickets/osteomalacia, whereas hyperphosphatemia causes cardiovascular events in chronic kidney disease (CKD) or hemodialysis patients. As a phosphaturic hormone, parathyroid hormone (PTH) or fibroblast growth factor (FGF) 23 strongly suppresses Pi reabsorption. 1,25-Dihydroxyvitamin D[1,25(OH) <sub>2</sub>D] up-regulates Pi absorption in intestines, and regulates urinary Pi excretion through PTH or FGF23. <br> Activated FGF23 signal leads urinary Pi excretion, and hypophosphatemic rickets (FGF23-related hypophosphatemic rickets). Rickets characterized as vitamin D deficiency also associates with impaired renal Pi reabsorption in juvenile stage in addition to low Pi absorption in intestines. Now, burosumab (FGF23 neutralizing antibody) has a beneficent effect on FGF23-related hypophosphatemic rickets/osteomalacia. The antibody increases renal Pi reabsorption and 1,25(OH) <sub>2</sub>D production. On the other hand, treatment with vitamin D alone in an animal model of X-linked hypophosphatemic rickets can potentially increase renal Pi reabsorption, despite of excess FGF23, and improve hypophosphatemia and bone phenotypes. <br> CKD patients often accompany with mineral bone disorder (CKD-MBD) such as hyperparathyroidism, cardiovascular calcification, and osteodystrophy. Prevention and treatment for hyperphosphatemia or hypovitaminosis D would improve their QOL or mortality. <br> Thus, renal Pi reabsorption is important for bone and mineral homeostasis. We focus on the metabolism of Pi and vitamin D to understand the molecular mechanism for the onset and prevention of diseases associated with Pi and vitamin D. (Keyword) Phosphate / Vitamin D / VDR / Rickets / CKD (Link to Publication Site) ● Publication site (DOI): 10.20632/vso.95.5-6_280 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390574047045835904 ● Search Scopus @ Elsevier (DOI): 10.20632/vso.95.5-6_280 (DOI: 10.20632/vso.95.5-6_280, CiNii: 1390574047045835904)

Proceeding of Domestic Conference:

1.	宇賀穂, 金子一郎, 佐々木すみれ, 小池萌, 谷藤和也, 川原滉太, 小宮蒼, 原田和, 浜口ゆき, 三浦美月, Yuji Shiozaki and Hiroko Segawa : 小腸Cytochrome P450(CYP3A)がビタミンD活性に及ぼす影響, 第54回日本栄養・食糧学会中国・四国支部大会・第7回日本栄養改善学会四国支部学術総会合同大会, Oct. 2021.
2.	川原滉太, 小池萌, 佐々木すみれ, 谷藤和也, Yuji Shiozaki, 金子一郎 and Hiroko Segawa : ライフステージに着目した生体内リン代謝の性差検討, 第68回日本栄養改善学会学術総会, Oct. 2021.
3.	川原滉太, 小池萌, 佐々木すみれ, 谷藤和也, Yuji Shiozaki, 金子一郎 and Hiroko Segawa : ライフステージに着目した生体内リン代謝の性差検討, 第75回日本栄養・食糧学会大会, Jul. 2021.

Et cetera, Workshop:

1.	Yuji Shiozaki and Hiroko Segawa : 腎リン酸トランスポーターの機能制御と疾患, 第16回トランスポーター研究会年会, Jul. 2022.
2.	Yuji Shiozaki, 佐々木すみれ, 小池萌, 谷藤和也, 川原滉太, 浜口ゆき, 金子一郎, Ken-ichi Miyamoto and Hiroko Segawa : 近位尿細管細胞分化におけるリン酸トランスポーターNaPi-IIcの役割, 第1回トランスポーター研究会関西西部会JTRAKansai2021∼トランスポーター研究の架け橋∼, Oct. 2021.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

細胞内リン酸排出分子XPR1による抗組織老化作用の解明 (Project/Area Number: 22K17800 )
抗老化因子を制御するミネラル栄養学の確立 (Project/Area Number: 21H03375 )
Search by Researcher Number (70908748)