Tokushima University / Educator and Researcher Directory --- Kubo, Yoshiaki

Personal Web Page

https://researchmap.jp/read0046124 (researchmap)

Field of Study

○	molecular and cellular biology of the skin

Subject of Study

○	皮膚癌や遺伝性皮膚疾患における分子細胞生物学的研究とその臨床応用 (皮膚発癌, 遺伝性皮膚疾患, 遺伝子変異, 遺伝子発現, 表皮角化細胞)

Book / Paper

Book:

1.	Yoshiaki Kubo : 皮膚疾患最新の治療 2023-2024, NANZANDO Co.,Ltd., Tokyo, Jan. 2023.
2.	Yoshiaki Kubo : リーシュマニア症, 文光堂, 東京, May 2022.
3.	Yoshiaki Kubo : 皮膚疾患診療実践ガイド第3版, 文光堂, Tokyo, May 2022.
4.	Yoshiaki Kubo : ツツガムシ病・日本紅斑熱・SFTS, 文光堂, 東京, May 2022.
5.	Yoshiaki Kubo : 母斑性基底細胞癌症候群, 医学書院, 東京, Mar. 2022.
6.	Yoshiaki Kubo : メラノーマの危険因子 (1)環境因子，宿主因子，臨床遺伝学およびリスク評価, May 2021.
7.	Yoshiaki Kubo : 結節性多発動脈炎, Nankodo, Mar. 2021.
8.	Yoshiaki Kubo : 代表的ながん遺伝子, IGAKU-SHOIN Ltd.Tokyo,Japan, Feb. 2020.
9.	Yoshiaki Kubo : 皮膚癌, IGAKU-SHOIN Ltd.Tokyo,Japan, 東京, Jan. 2019.
10.	Yoshiaki Kubo and Yoshihiro Matsudate : 血管腫・血管奇形臨床アトラスその他血管奇形をきたしうる疾患(Cowden病，Ehles-Danlos症候群IV), Nankodo, Tokyo, May 2018.
11.	Yoshiaki Kubo : 皮膚科からみた歯科との連携, クインテッセンス, Tokyo, Sep. 2017.
12.	Yoshiaki Kubo : 汗孔角化症, 南江堂, 東京, Jan. 2017.
13.	Yoshihiro Matsudate and Yoshiaki Kubo : 顔面の不整形潰瘍から疑うtrigeminal trophic syndrome, Nakayama-Shoten Co., Ltd., Oct. 2013.
14.	Yoshiaki Kubo : Cronkhite-Canada症候群, Nakayama-Shoten Co., Ltd., Tokyo, Sep. 2013.
15.	Yoshiaki Kubo : PTEN hamartoma tumor syndrome, Nakayama-Shoten Co., Ltd., Tokyo, Sep. 2013.
16.	Yoshiaki Kubo : Cowden病, Nakayama-Shoten Co., Ltd., Tokyo, Sep. 2013.
17.	Yoshiaki Kubo : Gardner症候群, Nakayama-Shoten Co., Ltd., Tokyo, Sep. 2013.
18.	Yoshiaki Kubo : 脂漏性皮膚炎，ふけ症, IGAKU-SHOIN Ltd.Tokyo,Japan, Tokyo, Dec. 2012.
19.	Yoshiaki Kubo : ツツガムシ病，日本紅斑熱, Nankodo, 東京, Dec. 2012.
20.	Yasutoshi Hida and Yoshiaki Kubo : Werner症候群, Kodansha, Nov. 2011.
21.	Yoshiaki Kubo : 成人T細胞白血病・リンパ腫, Nankodo, Jan. 2011.
22.	Yoshiaki Kubo : 円形脱毛症, 医学書院, Mar. 2010.
23.	Kazutoshi Murao, Yoshiaki Kubo, D Fukumoto, Kazuya Matsumoto and Seiji Arase : Verrucous carcinoma of the scalp associated with human papillomavirus type 33, Blackwell Publishing Ltd, Oct. 2005. (Summary) Verrucous carcinoma (VC) is a low-grade, well-differentiated squamous cell carcinoma of the skin or mucosae, and human papillomavirus (HPV) infection has been considered to be one of the causative factors of VC at three main sites, including the oral cavity, the genitoanal region, and the foot. However, the relationship between cutaneous VC at other sites and HPV infection remains obscure. We describe a rare case of cutaneous VC originating in a burn scar on the scalp and our attempt to find HPV infection in the lesion. We investigated the presence of HPV by polymerase chain reaction-restriction fragment length polymorphisms and immunohistochemical analysis. HPV type 33 was detected in the lesion, and positive stains for HPV were observed in several cell nuclei at the upper stratum malpighi. Since HPV type 33, as well as HPV types 16 and 18, is regarded as a high-risk, mucosal type, HPV type 33 infection likely contributed to the development of the lesion. We suggest that HPV infection should be relevant to a subset of cutaneous VC. (Keyword) Aged, 80 and over / Carcinoma, Verrucous / Female / Humans / Immunohistochemistry / Oncogene Proteins, Viral / Papillomavirus Infections / Polymerase Chain Reaction / Polymorphism, Restriction Fragment Length / Scalp / Skin Neoplasms / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1524-4725.2005.31222 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16188198 ● Search Scopus @ Elsevier (PMID): 16188198 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1524-4725.2005.31222 (DOI: 10.1111/j.1524-4725.2005.31222, PubMed: 16188198)
24.	Kazutoshi Murao, Yoshiaki Kubo, Kosaku Fukuhara, Kazuya Matsumoto and Seiji Arase : Three cases of Bowen's disease on the lower abdomen associated with high-risk types 16, 33, and 59 of human papillomavirus, Elsevier Science, Apr. 2005. (Keyword) Abdomen / Aged / Bowen's Disease / Human papillomavirus 16 / Humans / Male / Papillomaviridae / Papillomavirus Infections / Risk Factors / Skin Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jaad.2004.11.042 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15793544 ● Search Scopus @ Elsevier (PMID): 15793544 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jaad.2004.11.042 (DOI: 10.1016/j.jaad.2004.11.042, PubMed: 15793544)
25.	Kazutoshi Murao, Yoshiaki Kubo, Hirotsugu Takiwaki, Seiji Arase and Kazuya Matsumoto : Bowen's disease on the sole: p16INK4a overexpression associated with human papillomavirus type 16, Blackwell Publishing Ltd, Jan. 2005. (Summary) We report a case of Bowen's disease on the sole presenting clinically as an exophytic, blackish-grey, verrucous tumour, and showing human papillomavirus (HPV) type 16 on analysis with polymerase chain reaction. Positive stains for HPV particles by immunohistochemical analysis were limited to several cell nuclei at the upper stratum Malpighii. However, all the tumour cells in the epidermis exhibited strong and diffuse nuclear and cytoplasmic stains for the tumour suppressor protein p16INK4a. We speculate that dysregulation of the retinoblastoma/p16INK4a pathway may be involved in the pathogenesis of the lesion, and p16INK4a overexpression might serve as a useful surrogate marker for identifying Bowen's disease harbouring high-risk types of HPV infection. (Keyword) Adult / Bowen's Disease / Cyclin-Dependent Kinase Inhibitor p16 / DNA, Viral / Female / Foot Diseases / Humans / Papillomaviridae / Papillomavirus Infections / Skin Neoplasms / Tumor Markers, Biological (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1365-2133.2005.06365.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15656821 ● Search Scopus @ Elsevier (PMID): 15656821 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1365-2133.2005.06365.x (DOI: 10.1111/j.1365-2133.2005.06365.x, PubMed: 15656821)

Academic Paper (Judged Full Paper):

1.	Kazutoshi Murao, Yuko Hori, Riko Endo, Ayaka Iwawaki and Yoshiaki Kubo : A case of vitiligo that followed the path of a varicose vein in the lower leg., The Journal of Medical Investigation : JMI, Vol.71, No.1,2, 177-178, 2024. (Tokushima University Institutional Repository) ● Metadata: 119476 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.71.177 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.71.177 (Tokushima University Institutional Repository: 119476, DOI: 10.2152/jmi.71.177)
2.	Kazutoshi Murao, 宇都宮正裕 and Yoshiaki Kubo : A case of intralymphatic histiocytosis mimicking lymphangioma circumscriptum associated with a puncture wound caused by a thorn, Journal of the Japan Organization of Clinical Dermatologists, Vol.41, No.1, 55-59, 2024. (Keyword) intralymphatic histiocytosis / リンパ管拡張 / 棘 / 組織球 / 外傷 / lymphangiectasia / thorn / histiocyte / trauma (Link to Publication Site) ● Publication site (DOI): 10.3812/jocd.41.55 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390299682763670272 ● Search Scopus @ Elsevier (DOI): 10.3812/jocd.41.55 (DOI: 10.3812/jocd.41.55, CiNii: 1390299682763670272)
3.	Maki Hosoki, Yoshifumi Okamoto, Toyoko Tajima, Mayu Miyagi, Yoshiaki Kubo, Maiko Sogawa, R Raju, S Afroz and Yoshizo Matsuka : Risk of an immediate-type allergy to minocycline hydrochloride ointment, Operative Dentistry, Endodontology and Periodontology, Vol.3, No.1, 152-157, 2023. (Keyword) allergy / urticaria / minocycline hydrochloride ointment (Link to Publication Site) ● Publication site (DOI): 10.11471/odep.2023-018 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390298698490328576 ● Search Scopus @ Elsevier (DOI): 10.11471/odep.2023-018 (DOI: 10.11471/odep.2023-018, CiNii: 1390298698490328576)
4.	Rie Hayashi, Kanako Yamasaki, Tetsuya Hida, Kazutoshi Murao and Yoshiaki Kubo : ヒト乳頭腫ウイルスが検出された肛囲のBowen病・Bowen癌の3例, Japanese Journal of Clinical Dermatology, Vol.77, No.12, 1085-1090, 2023. (Link to Publication Site) ● Publication site (DOI): 10.11477/mf.1412207162 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390017046610681344 ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1412207162 (DOI: 10.11477/mf.1412207162, CiNii: 1390017046610681344)
5.	Kazutoshi Murao and Yoshiaki Kubo : Podoplanin-positive cells located in the basal layer of Bowen disease include tumor cells with cancer stem cell properties., The Journal of Dermatology, Vol.50, No.12, 1560-1567, 2023. (Summary) Podoplanin (PDPN) is widely used as a marker of lymphatic endothelial cells. PDPN is also involved in tumor progression, and upregulated PDPN expression is often found in various cancers. In this study, we first immunohistochemically examined PDPN expression in 87 cases of Bowen disease. Positive expression was detected in 64.4% of Bowen disease specimens, and the positive cells were exclusively located in the basal layer and corresponded to palisaded basal cells (PBCs). PBCs have been considered to be residual normal keratinocytes so far, but PDPN expression in cancers is generally associated with poor clinical outcomes. We also examined PDPN expression in 27 cases of Bowen carcinoma. Diffuse and strong PDPN expression was detected in 22.2% of Bowen carcinoma specimens, and another 22.2% showed PDPN expression at the leading edges of tumor nests. These results prompted us to determine whether PDPN-positive cells are more tumorigenic than PDPN-negative cells. We cultured Bowen disease cells using a three-dimensional (3D) cell culture system and examined PDPN expression. In the cultured Bowen disease tissue, PDPN expression was again detected in the basal layer. Then, we isolated 1.2 × 10 PDPN-positive and -negative cells from the 3D organotypic culture of Bowen disease by fluorescence-activated cell sorting analysis and compared their tumorigenicity using 3D culture. The PDPN-positive tumor cells were able to regenerate Bowen disease tissue, but the PDPN-negative tumor cells were not. In addition, the regenerated Bowen disease tissue derived from the PDPN-positive cells exhibited PDPN expression in its basal layer, as the parental Bowen disease tissue did. These results indicate that PDPN-positive cells include tumor cells with cancer stem cell properties. Although the precise mechanism through which PDPN expression is involved in the pathogenesis of Bowen disease needs to be determined, PDPN may be a novel druggable target for Bowen disease. (Keyword) Humans / Bowen's Disease / Membrane Glycoproteins / Endothelial Cells / Skin Neoplasms / Neoplastic Stem Cells (Link to Publication Site) ● Publication site (DOI): 10.1111/1346-8138.16943 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37658727 ● Search Scopus @ Elsevier (PMID): 37658727 ● Search Scopus @ Elsevier (DOI): 10.1111/1346-8138.16943 (DOI: 10.1111/1346-8138.16943, PubMed: 37658727)
6.	Tetsuji Takayama, Naoki Muguruma, Masanori Igarashi, shozo Ohsumi, Shiro Oka, Fumihiko Kakuta, Yoshiaki Kubo, Hideki Kumagai, Mika Sasaki, Tamotsu Sugai, Kokichi Sugao, Yuko Takeda, Hisashi Doyama, Kouji Bannno, Suguru Fukahori, Yoichi Furukawa, Takahiro Horimatsu, Ishikawa Hideki, Takeo Iawama, Yasushi Okazaki, Yutaka Saito, Nariaki Matsuura, Michihiro Mutoh, Naohiro Tomita, Takashi Akiyama, Toshiki Yamamoto, Hideyuki Ishida and Nakayama Yoshiko : Clinical Guidelines for Diagnosis and Management of Cowden Syndrome/PTEN Hamartoma Tumor Syndrome in Children and Adults-Secondary Publication., Journal of the Anus, Rectum and Colon, Vol.7, No.4, 284-300, 2023. (Summary) Cowden syndrome (CS)/ hamartoma tumor syndrome (PHTS) is a rare autosomal dominantly inherited condition caused by germline pathogenesis. It is associated with multiple hamartomatous lesions occurring in various organs and tissues, including the gastrointestinal tract, skin, mucous membranes, breast, thyroid, endometrium, and brain. Macrocephaly or multiple characteristic mucocutaneous lesions commonly develop in individuals in their 20s. This syndrome is occasionally diagnosed in childhood due to the occurrence of multiple gastrointestinal polyps, autism spectrum disorders, and intellectual disability. CS/PHTS can be diagnosed taking the opportunity of multigene panel testing in patients with cancer. Appropriate surveillance for early diagnosis of associated cancers is required because patients have a high risk of cancers including breast, thyroid, colorectal, endometrial, and renal cancers. Under these circumstances, there is growing concern regarding the management of CS/PHTS in Japan, but there are no available practice guidelines. To address this situation, the guideline committee, which included specialists from multiple academic societies, was organized by the Research Group on Rare and Intractable Diseases granted by the Ministry of Health, Labour, and Welfare, Japan. The present clinical guidelines explain the principles in the diagnosis and management of CS/PHTS, together with four clinical questions and the corresponding recommendations, incorporating the concept of the Grading of Recommendations Assessment, Development, and Evaluation system. Herein, we present an English version of the guideline, some of which have been updated, to promote seamless implementation of accurate diagnosis and appropriate management of pediatric, adolescent, and adult patients with CS/PHTS. (Link to Publication Site) ● Publication site (DOI): 10.23922/jarc.2023-028 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37900693 ● CiNii @ National Institute of Informatics (CRID): 1390860852414606720 ● Search Scopus @ Elsevier (PMID): 37900693 ● Search Scopus @ Elsevier (DOI): 10.23922/jarc.2023-028 (DOI: 10.23922/jarc.2023-028, PubMed: 37900693, CiNii: 1390860852414606720)
7.	岩脇文香, Yoshihiro Matsudate, Mariko Niki, Rie Hayashi and Yoshiaki Kubo : ヒドロキシクロロキンにより尋常性乾癬の増悪と薬疹を生じた1例, Hifuka No Rinsho, Vol.65, No.10, 1501-1504, 2023.
8.	岩脇文香, Yoshihiro Matsudate, 田蒔舞子, Mariko Niki, Kazutoshi Murao and Yoshiaki Kubo : 染毛剤により生じたchemical leukodermaの1例, Hifuka No Rinsho, Vol.65, No.10, 1553-1556, 2023. (Keyword) chemical leukoderma / p-phen-ylenediamine (Link to Publication Site) ● Publication site (DOI): 10.18888/hi.0000004161 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390860465164347648 ● Search Scopus @ Elsevier (DOI): 10.18888/hi.0000004161 (DOI: 10.18888/hi.0000004161, CiNii: 1390860465164347648)
9.	Mariko Niki and Yoshiaki Kubo : Cutaneous manifestations associated with COVID-19, Shikoku Acta Medica, Vol.79, No.1,2, 33-36, 2023. (Keyword) COVID-19 / GROUCH / sequelae / hair loss / vaccine (Link to Publication Site) ● Publication site (DOI): 10.57444/shikokuactamedica.79.1.2_33 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390015191534405248 ● Search Scopus @ Elsevier (DOI): 10.57444/shikokuactamedica.79.1.2_33 (DOI: 10.57444/shikokuactamedica.79.1.2_33, CiNii: 1390015191534405248)
10.	Kanako Yamasaki, 湊優子, 中島美世, Mariko Niki, Kazutoshi Murao, Yoshiaki Kubo and 小川瑛 : JAK阻害薬投与中の関節リウマチ患者に発症し蜂窩織炎様の所見を呈した皮膚クリプトコッカス症の1例, 皮膚科の臨床, Vol.65, No.2, 179-183, 2023.
11.	Kazutoshi Murao and Yoshiaki Kubo : A case of cutaneous collagenous vasculopathy, Journal of the Japan Organization of Clinical Dermatologists, Vol.39, No.6, 765-768, 2022. (Keyword) cutaneous collagenous vasculopathy / 毛細血管拡張 / PAS染色 / 抗collagen IV抗体 / telangiectasia / periodic acid Schiff stain / anti-collagen IV antibody (Link to Publication Site) ● Publication site (DOI): 10.3812/jocd.39.765 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390576591777414656 ● Search Scopus @ Elsevier (DOI): 10.3812/jocd.39.765 (DOI: 10.3812/jocd.39.765, CiNii: 1390576591777414656)
12.	Tomoya Mizutani, Takeshi Ishigami, Kazutoshi Murao, Yoshiaki Kubo, 中山泰介, Takashi Kitaichi, Tetsuya Kitagawa and 毛山剛 : 遺残坐骨動脈により生じた足背部難治性皮膚潰瘍の1例, Hifuka No Rinsho, Vol.64, No.3, 403-406, 2022. (Keyword) 遺残坐骨動脈 / 皮膚潰瘍 / 下肢虚血 / イザンザコツドウミャク / ヒフカイヨウ / カシキョケツ (Link to Publication Site) ● Publication site (DOI): 10.18888/hi.0000003160 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390291767698846976 ● Search Scopus @ Elsevier (DOI): 10.18888/hi.0000003160 (DOI: 10.18888/hi.0000003160, CiNii: 1390291767698846976)
13.	Satoshi Teramae, Naoki Muguruma, Koichi Okamoto, Kumiko Oseto, Ryutaro Nishikawa, Takayuki Tanoue, Keiji Hirata, Shunichi Yanai, Takayuki Matsumoto, Seiji Shimizu, Jun Miwa, Yu Sakaki, Kazuo Yashima, Hiroyuki Ohnuma, Yasushi Sato, Yoshitaka Kitayama, Yoshio Ohda, Atsushi Yamauchi, Yoji Sanomura, Kumiko Tanaka, Yoshiaki Kubo, Hideki Ishikawa, Yoshimi Bando, TOmoko Sonoda and Tetsuji Takayama : Cancer risk and genotype-phenotype correlation in Japanese patients with Cowden syndrome., International Journal of Clinical Oncology, Vol.27, No.4, 639-647, 2022. (Summary) Cowden syndrome (CS) is an autosomal-dominant hereditary disorder caused by a germline PTEN variant and characterized by multiple hamartomas and a high risk of cancers. However, no detailed data on CS in Asian patients nor genotype-phenotype correlation have been reported. We performed the first Japanese nationwide questionnaire survey on CS and obtained questionnaire response data on 49 CS patients. Patients included 26 females (median age 48 years). The incidence of breast, thyroid, endometrium, and colorectal cancer was 32.7%, 12.2%, 19.2% (among females), and 6.1%, respectively. The incidence of any cancers was relatively high among all patients (46.9%, 23/49), and particularly female patients (73.1%, 19/26), compared with previous reports from Western countries. Gastrointestinal (GI) polyps were more frequently found throughout the GI tract compared with previous studies. PTEN variants were detected in 95.6% (22/23) of patients; 12 in the N-terminal region (11 in phosphatase domain) and 10 in the C-terminal (C2 domain) region. The incidence of cancer in the C2 domain group was significantly higher than in the N-terminal region (phosphatase) group. All female patients with C2 domain variant had breast cancer. Our data suggest that Japanese patients with CS, particularly female patients and patients with C2 domain variant may have a high risk of cancers. (Keyword) Breast Neoplasms / Female / Genetic Association Studies / Hamartoma Syndrome, Multiple / Humans / Intestinal Polyps / Japan / Male / Middle Aged / PTEN Phosphohydrolase / Risk (Tokushima University Institutional Repository) ● Metadata: 117152 (Link to Publication Site) ● Publication site (DOI): 10.1007/s10147-022-02116-w (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35106660 ● Search Scopus @ Elsevier (PMID): 35106660 ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-022-02116-w (Tokushima University Institutional Repository: 117152, DOI: 10.1007/s10147-022-02116-w, PubMed: 35106660)
14.	Kazutoshi Murao, Kanako Yamasaki, Hirokazu Agawa, Mio Nakajima, Maiko Iwasaka and Yoshiaki Kubo : Bowen disease on the dorsum of the foot associated with human papillomavirus type 16, The Journal of Medical Investigation : JMI, Vol.69, No.1,2, 152-154, 2022. (Summary) A 94 years old Japanese female was presented to our hospital with a skin lesion on her left foot. A physical examination found a markedly hyperkeratotic reddish-brown plaque, measuring 3 cm in diameter. A biopsy specimen showed prominent papillomatosis, hyperkeratosis, and atypical keratinocytes throughout the epidermis. Individual cell keratinization, multinucleated keratinocytes, and many keratinocytes with clear cytoplasm were seen. We excised the lesion, and the skin grafting was used for covering the skin defect. We investigated whether human papillomavirus (HPV) was present in the lesion, and HPV 16 DNA was detected using the polymerase chain reaction. Immunohistochemical analysis showed several HPV-positive cells in the upper epidermis. In addition, the tumor cells showed strong and diffuse expression of p16INK4a. Bowen disease (BD) is an intraepidermal squamous cell carcinoma. The precise pathogenesis of BD is unclear, but it involves various factors. HPV infection is one of these factors and is a well-known cause of BD of the genitalia and fingers. It has been shown that some BD lesions occurring at other locations are also associated with HPV. Dysregulation of the Rb/p16INK4a pathway is considered to play an important role in HPV-induced BD, but the precise mechanism remains to be elucidated. J. Med. Invest. 69 : 152-154, February, 2022. (Keyword) Aged, 80 and over / Bowen's Disease / Cyclin-Dependent Kinase Inhibitor p16 / Female / Human papillomavirus 16 / Humans / Papillomaviridae / Papillomavirus Infections (Tokushima University Institutional Repository) ● Metadata: 117028 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.69.152 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35466139 ● Search Scopus @ Elsevier (PMID): 35466139 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.152 (Tokushima University Institutional Repository: 117028, DOI: 10.2152/jmi.69.152, PubMed: 35466139)
15.	Yasutaka Sato, Satoshi Sakaguchi, Kenshi Takechi, Masayuki Chuma, Kenta Yagi, Chikako Kane, Mitsuhiro Goda, Hirofumi Hamano, Yuki Aoe, Hiroshi Nokihara, Yoshiaki Kubo, Ichiro Hashimoto and Hiroaki Yanagawa : Trends in Investigator-Initiated Clinical Studies at a University Hospital after Enforcement of the 2018 Clinical Trials Act in Japan., Biological & Pharmaceutical Bulletin, Vol.45, No.3, 374-377, 2022. (Summary) In April 2018, the Clinical Trials Act pertaining to investigator-initiated clinical trials was passed in Japan. The purpose of this study was to investigate activity in investigator-initiated clinical studies before and after enforcement of the new Clinical Trials Act. This was done by analysing the records of the Ethics Committee of Tokushima University Hospital, which reviews studies based on the Japanese government's Ethical Guidelines for Medical and Health Research Involving Human Subjects prior to the Clinical Trials Act, and records of the Certified Review Board established at Tokushima University under the Clinical Trials Act in 2018. The number of new applications to these two review boards during fiscal years 2015-2017 (pre-Act) and fiscal years 2018 and 2019 (post-Act) were used as an indicator of activity in investigator-initiated clinical studies. The number of new applications to the Ethics Committee was 303, 261, 316, 303, and 249 in 2015, 2016, 2017, 2018, and 2019, respectively. The data show that the total number of new interventional studies decreased from 50.3 in average in 2015-2017 (pre-Act) to 42 in 2018 and 40 in 2019 (post-Act), respectively. These results suggest that fewer interventional studies were started following enforcement of the new Clinical Trials Act. To confirm this trend and identify contributing factors, further studies are required. In addition, possible way, such as broader contribution of clinical research coordinators, to promote clinical studies in the new Clinical Trials Act era should be examined. (Keyword) Clinical Trials as Topic / Hospitals, University / Humans / Japan (Tokushima University Institutional Repository) ● Metadata: 117363 (Link to Publication Site) ● Publication site (DOI): 10.1248/bpb.b21-00753 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35228403 ● CiNii @ National Institute of Informatics (CRID): 1390854717424551552 ● Summary page in Scopus @ Elsevier: 2-s2.0-85125568858 (Tokushima University Institutional Repository: 117363, DOI: 10.1248/bpb.b21-00753, PubMed: 35228403, CiNii: 1390854717424551552, Elsevier: Scopus)
16.	津田達也, Yoshiro Abe, Soushi Ishida, Kazuhide Mineda, Yutaro Yamashita, Shinji Nagasaka, 山﨑裕行, Yoshiaki Kubo and Ichiro Hashimoto : Sentinel lymph node biopsy for cutaneous malignant melanoma ; clinical significance, Skin Cancer, Vol.36, No.2, 173-179, 2021. (Keyword) Cutaneous malignant melanoma / lymph node dissection / sentinel lymph node biopsy (Link to Publication Site) ● Publication site (DOI): 10.5227/skincancer.36.173 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390289920608115072 ● Search Scopus @ Elsevier (DOI): 10.5227/skincancer.36.173 (DOI: 10.5227/skincancer.36.173, CiNii: 1390289920608115072)
17.	山崎佳那子, Rie Hayashi, Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : 下腿蜂窩織炎様の臨床像で再発した節外性NK/T細胞リンパ腫の1例, Hifuka No Rinsho, Vol.63, No.5, 687-690, 2021. (Keyword) 節外性NK/T細胞リンパ腫 / 蜂窩織炎 / EBER / 放射線療法 / セツガイセイ NK/Tサイボウリンパシュ / ホウカシキエン / ホウシャセンリョウホウ (Link to Publication Site) ● Publication site (DOI): 10.18888/hi.0000002553 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390569623316929280 ● Search Scopus @ Elsevier (DOI): 10.18888/hi.0000002553 (DOI: 10.18888/hi.0000002553, CiNii: 1390569623316929280)
18.	Yoshihiro Matsudate, 岩脇文香, Mariko Niki, 榊哲彦, 梶田啓介 and Yoshiaki Kubo : ニボルマブ，イピリムマブの併用療法によりVogt-小柳-原田病様ぶどう膜炎を生じた悪性黒色腫の1例, Hifuka No Rinsho, Vol.63, No.5, 575-579, 2021.
19.	Kazutoshi Murao and Yoshiaki Kubo : 足底に生じ，HPV33型DNAを検出したBowen病の1例, Journal of the Japan Organization of Clinical Dermatologists, Vol.38, No.1, 57-61, 2021. (Link to Publication Site) ● Publication site (DOI): 10.3812/jocd.38.57 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.3812/jocd.38.57 (DOI: 10.3812/jocd.38.57)
20.	岩坂麻衣子, Mio Yada, Yoshiaki Kubo and Kiyoe Kurahashi : 腹壁遠心性脂肪萎縮症の1例, Hifuka No Rinsho, Vol.62, No.13, 1929-1932, 2020. (Keyword) 腹壁遠心性脂肪萎縮症 / 成人 (Link to Publication Site) ● Publication site (DOI): 10.18888/hi.0000002309 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390568456343666560 ● Search Scopus @ Elsevier (DOI): 10.18888/hi.0000002309 (DOI: 10.18888/hi.0000002309, CiNii: 1390568456343666560)
21.	板東真由, Soushi Ishida, Keisuke Kashiwagi, 戸田皓大, Kunihisa Yamaguchi, Yoshiaki Kubo, Koichi Sairyo and Ichiro Hashimoto : A Case of Giant Basal Cell Carcinoma of the Penis with False-positive Metastasis on PET/CT, Japanese Journal of Plastic Surgery, Vol.63, No.12, 1578-1585, 2020. (Keyword) 基底細胞癌 / 陰茎 / PET/CT偽陽性 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522825130856436864 (CiNii: 1522825130856436864)
22.	山﨑佳那子, Yoshihiro Matsudate, Yoshiaki Kubo and 赤澤啓人 : 乳児の足趾に生じたHair-thread Tourniquet Syndrome, Hifuka No Rinsho, Vol.62, No.10, 1500-1501, 2020. (Link to Publication Site) ● Publication site (DOI): 10.18888/hi.0000002185 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390848647551768576 ● Search Scopus @ Elsevier (DOI): 10.18888/hi.0000002185 (DOI: 10.18888/hi.0000002185, CiNii: 1390848647551768576)
23.	田蒔舞子, Yoshihiro Matsudate, Yoshiaki Kubo and 古北一泰 : 石灰沈着を伴ったPencil-core Granulomaの1例, Hifuka No Rinsho, Vol.62, No.9, 1281-1284, 2020. (Keyword) pencil-core granuloma / 石灰沈着 / 鉛筆の芯 / 異物肉芽腫 (Link to Publication Site) ● Publication site (DOI): 10.18888/hi.0000002121 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390848250141523328 ● Search Scopus @ Elsevier (DOI): 10.18888/hi.0000002121 (DOI: 10.18888/hi.0000002121, CiNii: 1390848250141523328)
24.	山﨑佳那子, 宮本千暁, Mio Yada, Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : 急速に腎障害が進行したクリオグロブリン血症性血管炎, Practical Dermatology, Vol.42, No.6, 498-501, 2020. (Link to Publication Site) ● Publication site (DOI): 10.24733/pd.0000002047 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.24733/pd.0000002047 (DOI: 10.24733/pd.0000002047)
25.	Maiko Sogawa, Kazutoshi Murao, Yoshiaki Kubo, Kei Daizumoto and Hiro-omi Kanayama : 顔面に皮疹を認めなかったBirt-Hogg-Dube症候群の1例, Japanese Journal of Clinical Dermatology, Vol.73, No.13, 1089-1094, 2019. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390565134811658112 (CiNii: 1390565134811658112)
26.	Maiko Sogawa, Yoshihiro Matsudate, Kazutoshi Murao, Yoshiaki Kubo and Masahiro Utsunomiya : 疱疹状天疱瘡を合併した尋常性乾癬の1例, Japanese Journal of Clinical Dermatology, Vol.73, No.13, 1059-1064, 2019. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390846609788060544 (CiNii: 1390846609788060544)
27.	Maiko Iwasaka, Yoshihiro Matsudate, Maiko Tamaki, Kazutoshi Murao and Yoshiaki Kubo : 入院中に生じた緑膿菌性毛包炎の母子例, Hifuka No Rinsho, Vol.61, No.9, 1449-1453, 2019. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282763137538048 (CiNii: 1390282763137538048)
28.	Yoshihiro Matsudate and Yoshiaki Kubo : Malignant Melanoma with Hair Repigmentation, The Nishinihon Journal of Dermatology, Vol.81, No.3, 250-255, 2019. (Summary) <p><b>症例</b>:79 歳，男性</p><p><b>主訴</b>:頭頂部の痂皮を付着する結節</p><p><b>現病歴</b>:加齢に伴い毛髪は白毛になっていた．約 2 年前から右頭頂部の毛髪が茶褐色調に変化してきたが放置していた．2 カ月前から同部位に痂皮を付着する結節が生じ，徐々に増大傾向のため当科を受診した．</p><p><b>現症</b>:頭頂部右寄りの部位に限局して，毛髪は茶褐色調を呈していた(<b>図 1 a</b>)．同部位には境界不明瞭な不整形の黒褐色斑があり，内部には 11×11 mm の表面に潰瘍を伴う黒色結節を認めた(<b>図 1 b</b>)．</p><p><b>病理組織学的所見</b>:表皮から真皮深層にかけて好塩基性に染まる腫瘍胞巣が密に増殖していた(<b>図 2 a</b>)．腫瘍細胞は核の大小不同や核分裂像を伴っており，一部ではメラニン色素を含んでいた(<b>図 2 b</b>)．腫瘍近傍には，メラニン色素を含む毛包を認めた(<b>図 2 c</b>)．免疫組織化学染色では，腫瘍細胞は S-100，HMB-45(<b>図 2 d</b>)，Melan-A のいずれも陽性であった．Tumor thickness は 5 mm であった．摘出した右耳後部のセンチネルリンパ節に転移は認めなかった．</p><p><b>画像検査所見</b>:PET-CT で転移を疑う所見はなかった．</p><p><b>診断</b>:毛髪の色素再沈着を伴った悪性黒色腫(pT4bN0M0，stage Ⅱc)</p><p><b>治療および経過</b>:2 cm マージンをとり，骨膜上で切除した．断端陰性を確認後に，分層植皮術を行った．現在，術後 2 年以上経過しているが再発や転移を認めていない．</p> (Keyword) Dermatology (Link to Publication Site) ● Publication site (DOI): 10.2336/nishinihonhifu.81.163 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001288155818752 ● Summary page in Scopus @ Elsevier: 2-s2.0-85071950274 (DOI: 10.2336/nishinihonhifu.81.163, CiNii: 1390001288155818752, Elsevier: Scopus)
29.	Keita Takemoto, Teruhiko Makino, Megumi Mizawa, Yoshiaki Kubo and Tadamichi Shimizu : Missense mutation Y449H of the K10 gene in a patient with severe epidermolytic ichthyosis., European Journal of Dermatology : EJD, Vol.29, No.2, 227-228, 2019. (Link to Publication Site) ● Publication site (DOI): 10.1684/ejd.2019.3519 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31106763 ● Search Scopus @ Elsevier (PMID): 31106763 ● Search Scopus @ Elsevier (DOI): 10.1684/ejd.2019.3519 (DOI: 10.1684/ejd.2019.3519, PubMed: 31106763)
30.	Yoshihiro Matsudate, Kazutoshi Murao, Yoshiaki Kubo and 高橋収 : Erythema Multiforme Associated with Chemical Burn Due to the Herbicides Alachlor, Hifuka No Rinsho, Vol.61, No.2, 225-228, 2019. (Keyword) 多形紅斑 / アラクロール / 除草剤 / 接触皮膚炎 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001288159209728 (CiNii: 1390001288159209728)
31.	Kazutoshi Murao and Yoshiaki Kubo : Condyloma acuminatum of the nipple resembling seborrheic keratosis, Journal of the Japan Organization of Clinical Dermatologists, Vol.36, No.1, 35-38, 2019. (Summary) A 25-year-old Japanese female presented with a skin lesion on her left nipple. The lesion had been present for three months and was increasing in size. A physical examination revealed a brown hyperkeratotic verrucous nodule on her left nipple. A histological examination of a biopsy specimen showed hyperkeratosis, papillo-matosis, and acanthosis. There were several koilocytes in the upper epidermis. Positive staining for human papillomavirus (HPV) particles by immunohistochemical analysis was seen in several cell nuclei at the upper malpighian layer. Mucous-type HPV DNA was detected in the lesion using the polymerase chain reaction (PCR), and it was identified as HPV type 6 by direct sequencing of the PCR product. We treated the patient by cryotherapy with liquid nitrogen, and the lesion disappeared. Condyloma acuminatum of the nipple is very rare. Interestingly, most reported clinical cases exhibit a seborrheic keratosis-like appearance. Dermatologists should consider condyloma acuminatum in cases in which seborrheic keratosis-like lesions are shown on the nipple. (Keyword) condylomaacuminatum / humanpapillomavirus / nipple / seborrheickeratosis (Link to Publication Site) ● Publication site (DOI): 10.3812/jocd.36.35 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390567172583001600 ● Search Scopus @ Elsevier (DOI): 10.3812/jocd.36.35 (DOI: 10.3812/jocd.36.35, CiNii: 1390567172583001600)
32.	阿河弘和, Yoshihiro Matsudate, Kenji Hirose, Kazutoshi Murao, Yoshihisa Sakao and Yoshiaki Kubo : CASE REPORTS : Contact Dermatitis Syndrome Due to Betamethasone Valerate, Hifuka No Rinsho, Vol.61, No.1, 63-66, 2019. (Keyword) ベタメタゾン吉草酸エステル / 接触皮膚炎症候群 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390845713090947840 (CiNii: 1390845713090947840)
33.	Naoto Okada, Hitoshi Kawazoe, Kenshi Takechi, Yoshihiro Matsudate, Ryo Utsunomiya, Yoshito Zamami, Mitsuhiro Goda, Masaki Imanishi, Masayuki Chuma, Noriaki Hidaka, Koji Sayama, Yoshiaki Kubo, Akihiro Tanaka and Keisuke Ishizawa : Association Between Immune-Related Adverse Events and Clinical Efficacy in Patients with Melanoma Treated With Nivolumab: A Multicenter Retrospective Study., Clinical Therapeutics, Vol.41, No.1, 59-67, 2018. (Summary) Our study indicated that clinical response with nivolumab treatment improves with irAE occurrence in patients with melanoma. Moreover, the early increase in peripheral lymphocyte count may act as a biomarker for predicting the occurrence of irAEs induced by nivolumab. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.clinthera.2018.11.004 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30528047 ● Summary page in Scopus @ Elsevier: 2-s2.0-85057595502 (DOI: 10.1016/j.clinthera.2018.11.004, PubMed: 30528047, Elsevier: Scopus)
34.	Yoshihiro Matsudate, 木下華子, Tomoya Mizutani, Kazutoshi Murao and Yoshiaki Kubo : A case of cutaneous anaplastic large cell lymphoma with pseudocarcinomatous hyperplasia, Japanese Journal of Clinical Dermatology, Vol.72, No.12, 999-1004, 2018. (Keyword) 偽癌性増殖 / リンパ腫様丘疹症 / 皮膚未分化大細胞リンパ腫 / 原発性皮膚CD30陽性リンパ増殖異常症 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390845713027619712 (CiNii: 1390845713027619712)
35.	木下華子, Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : オウゴンクジャクヒバによる接触皮膚炎症候群の1例, Hifuka No Rinsho, Vol.60, No.3, 430-431, 2018. (Link to Publication Site) ● Publication site (DOI): 10.18888/hi.0000000640 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390845713092528768 ● Search Scopus @ Elsevier (DOI): 10.18888/hi.0000000640 (DOI: 10.18888/hi.0000000640, CiNii: 1390845713092528768)
36.	Kenji Hirose, 宮本千暁, Yoshihiro Matsudate, Yoshiaki Kubo, Tatsuya Taniguchi and Yoshimi Bando : 関節症性乾癬に続発した反応性アミロイドーシス, Practical Dermatology, Vol.39, No.12, 1291-1294, 2017. (Link to Publication Site) ● Publication site (DOI): 10.24733/J01268.2018134054 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.24733/J01268.2018134054 (DOI: 10.24733/J01268.2018134054)
37.	Yoshihiro Matsudate and Yoshiaki Kubo : 母斑性基底細胞癌症候群の遺伝子診断, Practical Dermatology, Vol.39, No.11, 1122-1127, 2017. (Link to Publication Site) ● Publication site (DOI): 10.24733/J01268.2018058672 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.24733/J01268.2018058672 (DOI: 10.24733/J01268.2018058672)
38.	Yoshihiro Matsudate, Kazutoshi Murao, 浦野芳夫 and Yoshiaki Kubo : 留置針外套による接触皮膚炎, Practical Dermatology, Vol.39, No.7, 735-738, 2017. (Link to Publication Site) ● Publication site (DOI): 10.24733/J01268.2017304604 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.24733/J01268.2017304604 (DOI: 10.24733/J01268.2017304604)
39.	Yoshihiro Matsudate, Takuya Naruto, Yumiko Hayashi, Mitsuyoshi Minami, Mikiko Tohyama, Kenji Yokota, Daisuke Yamada, Issei Imoto and Yoshiaki Kubo : Target exome sequencing and chromosomal microarray for the molecular diagnosis of nevoid basal cell carcinoma syndrome, Journal of Dermatological Science, Vol.86, No.3, 206-211, 2017. (Summary) Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder mainly caused by heterozygous mutations of PTCH1. In addition to characteristic clinical features, detection of a mutation in causative genes is reliable for the diagnosis of NBCCS; however, no mutations have been identified in some patients using conventional methods. To improve the method for the molecular diagnosis of NBCCS. We performed targeted exome sequencing (TES) analysis using a multi-gene panel, including PTCH1, PTCH2, SUFU, and other sonic hedgehog signaling pathway-related genes, based on next-generation sequencing (NGS) technology in 8 cases in whom possible causative mutations were not detected by previously performed conventional analysis and 2 recent cases of NBCCS. Subsequent analysis of gross deletion within or around PTCH1 detected by TES was performed using chromosomal microarray (CMA). Through TES analysis, specific single nucleotide variants or small indels of PTCH1 causing inferred amino acid changes were identified in 2 novel cases and 2 undiagnosed cases, whereas gross deletions within or around PTCH1, which are validated by CMA, were found in 3 undiagnosed cases. However, no mutations were detected even by TES in 3 cases. Among 3 cases with gross deletions of PTCH1, deletions containing the entire PTCH1 and additional neighboring genes were detected in 2 cases, one of which exhibited atypical clinical features, such as severe mental retardation, likely associated with genes located within the 4.3Mb deleted region, especially. TES-based simultaneous evaluation of sequences and copy number status in all targeted coding exons by NGS is likely to be more useful for the molecular diagnosis of NBCCS than conventional methods. CMA is recommended as a subsequent analysis for validation and detailed mapping of deleted regions, which may explain the atypical clinical features of NBCCS cases. (Keyword) Adolescent / Adult / Basal Cell Nevus Syndrome / Biomarkers, Tumor / Chromosomes, Human / Computational Biology / DNA Copy Number Variations / DNA Mutational Analysis / Exome / Female / Gene Dosage / Genetic Predisposition to Disease / High-Throughput Nucleotide Sequencing / Humans / INDEL Mutation / Male / Middle Aged / Molecular Diagnostic Techniques / Oligonucleotide Array Sequence Analysis / Phenotype / Polymorphism, Single Nucleotide / Predictive Value of Tests / Reproducibility of Results / Young Adult (Tokushima University Institutional Repository) ● Metadata: 110418 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jdermsci.2017.02.282 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28342698 ● Summary page in Scopus @ Elsevier: 2-s2.0-85015941648 (Tokushima University Institutional Repository: 110418, DOI: 10.1016/j.jdermsci.2017.02.282, PubMed: 28342698, Elsevier: Scopus)
40.	K Yamasaki, H Nakagawa, Yoshiaki Kubo and K Ootaki : Efficacy and safety of brodalumab in patients with generalized pustular psoriasis and psoriatic erythroderma: results from a 52-week, open-label study., The British Journal of Dermatology, Vol.176, No.3, 741-751, 2017. (Summary) A T-helper (Th) cell subset Th17 preferentially produces interleukin (IL)-17 and plays a pivotal role in the pathogenesis of psoriasis. However, the pathological roles of IL-17 cascades in generalized pustular psoriasis (GPP) and psoriatic erythroderma (PsE) have not been well established. To evaluate the efficacy and safety of brodalumab, a human immunoglobulin G2 monoclonal antibody against human IL-17-receptor A (IL-17RA), in Japanese patients with GPP and PsE. This was an open-label, multicentre, long-term phase III study in Japanese patients with rare and severe types of psoriasis. Patients received brodalumab 140 mg at day 1 and weeks 1 and 2, and then every 2 weeks until week 52. The primary endpoint was the Clinical Global Impression of Improvement (CGI). Safety evaluations included treatment-emergent adverse events (AEs) and changes in laboratory parameters. A total of 12 patients with GPP and 18 with PsE were enrolled. Ten patients with GPP and 16 with PsE completed the study. At week 52 (last observation carried forward), CGI remission or improvement was achieved in 11 patients with GPP and 18 with PsE. The most commonly reported AE was nasopharyngitis (33 3%). Five serious AEs occurred during the study. However, none was considered treatment-related. Brodalumab significantly improved the symptoms of patients with GPP and PsE throughout the 52 weeks, and demonstrated favourable safety profiles without any new safety signals. Inhibition of IL-17RA-mediated signalling by brodalumab is expected to be a promising new treatment option for patients with GPP and PsE. (Keyword) Adult / Antibodies, Monoclonal / Dermatitis, Exfoliative / Dermatologic Agents / Dose-Response Relationship, Drug / Drug Administration Schedule / Female / Humans / Injections, Subcutaneous / Long-Term Care / Male / Middle Aged / Psoriasis / Treatment Outcome (Tokushima University Institutional Repository) ● Metadata: 115032 (Link to Publication Site) ● Publication site (DOI): 10.1111/bjd.14702 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27106510 ● Search Scopus @ Elsevier (PMID): 27106510 ● Search Scopus @ Elsevier (DOI): 10.1111/bjd.14702 (Tokushima University Institutional Repository: 115032, DOI: 10.1111/bjd.14702, PubMed: 27106510)
41.	木下華子, Yoshihiro Matsudate, Kazutoshi Murao, Yoshiaki Kubo, 長江哲夫 and 荒瀬誠治 : ゴム加硫促進剤による接触皮膚炎症候群の1例, Hifuka No Rinsho, Vol.58, No.13, 1921-1925, 2016. (Keyword) 加硫促進剤 / ジチオカーバメイト系化合物 / 接触皮膚炎症候群 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1523106605479673472 (CiNii: 1523106605479673472)
42.	Mayu Yuasa, Kazutoshi Murao and Yoshiaki Kubo : 陰茎に生じたCalciphylaxisの1例, Hifuka No Rinsho, Vol.58, No.12, 1904-1905, 2016. (Link to Publication Site) ● Publication site (DOI): 10.18888/J01266.2017081165 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.18888/J01266.2017081165 (DOI: 10.18888/J01266.2017081165)
43.	祖川麻衣子, Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : ソラフェニブ投与中に生じたケラトアカントーマの1例, Hifuka No Rinsho, Vol.58, No.9, 1353-1356, 2016. (Keyword) ソラフェニブ / ケラトアカントーマ (Link to Publication Site) ● Publication site (DOI): 10.18888/j01266.2016373702 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282763137435776 ● Search Scopus @ Elsevier (DOI): 10.18888/j01266.2016373702 (DOI: 10.18888/j01266.2016373702, CiNii: 1390282763137435776)
44.	Yoshiaki Kitamura, Hiroyuki Mizuguchi, Kentaro Okamoto, Mika Kitayama, Tatsuya Fujii, Akira Fujioka, Toshio Matsushita, Takashi Mukai, Yoshiaki Kubo, Nobuo Kubo, Hiroyuki Fukui and Noriaki Takeda : Irradiation with narrowband-ultraviolet B suppresses phorbol ester-induced up-regulation of H1 receptor mRNA in HeLa cells, Acta Oto-Laryngologica, Vol.136, No.4, 409-413, 2016. (Summary) Conclusion These findings suggest that low dose irradiation with 310 nm NB-UVB specifically suppressed the up-regulation of H1R gene expression without inducing apoptosis and that UVB of shorter or longer wavelength than 310 nm NB-UVB had no such effects. Objective To develop a narrowband-ultraviolet B(NB-UVB) phototherapy for allergic rhinitis, this study investigated the effects of irradiation with NB-UVB at wavelength of 310 nm on phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H1 receptor (H1R) mRNA in HeLa cells. Methods The mRNA levels of H1R in HeLa cells were measured using real-time RT-PCR. Apoptosis were evaluated with DNA fragmentation assay. Results PMA induced a significant increase in H1R mRNA expression in HeLa cells. Irradiation with 305 nm UVB and 310 nm NB-UVB, but not with 315 nm UVB at doses of 200 and 300 mJ/cm(2) significantly suppressed PMA-induced up-regulation of H1R mRNA. At a dose of 200 mJ/cm(2), irradiation with 305 nm UVB, but not with 310 nm NB-UVB, induced apoptosis, although exposure of the cells to both 305 and 310 nm UVB induced apoptosis at a dose of 300 mJ/cm(2) after PMA treatment in HeLa cells. Conversely, irradiation with 315 nm UVB at doses of 200 and 300 mJ/cm(2) did not induce apoptosis. (Keyword) Epithelial Cells / HeLa Cells / Humans / Phorbol Esters / Receptors, Histamine H1 / Rhinitis, Allergic / Ultraviolet Therapy (Link to Publication Site) ● Publication site (DOI): 10.3109/00016489.2015.1129555 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26824787 ● Search Scopus @ Elsevier (PMID): 26824787 ● Search Scopus @ Elsevier (DOI): 10.3109/00016489.2015.1129555 (DOI: 10.3109/00016489.2015.1129555, PubMed: 26824787)
45.	Yoshiaki Kubo, Toshitatsu Nogita, Ikuko Kimura, Mami Chiba and Kanako Sakakibara : Interventional Evaluation of Monoammonium Glycyrrhizinate-Glycine/DLMethionine Combination Tablets in Mild Alopecia Areata, Journal of Clinical & Experimental Dermatology Research, Vol.7, No.1, 322, 2016. (Tokushima University Institutional Repository) ● Metadata: 113024 (Link to Publication Site) ● Publication site (DOI): 10.4172/2155-9554.1000322 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.4172/2155-9554.1000322 (Tokushima University Institutional Repository: 113024, DOI: 10.4172/2155-9554.1000322)
46.	Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : ヒアレインミニ点眼液とミドリンP点眼液による接触皮膚炎, Practical Dermatology, Vol.37, No.5, 475-478, 2015. (Link to Publication Site) ● Publication site (DOI): 10.24733/J01268.2015266464 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.24733/J01268.2015266464 (DOI: 10.24733/J01268.2015266464)
47.	Rie Yamamura, Kazuhiro Furukita, Kazutoshi Murao and Yoshiaki Kubo : Graham-Little症候群, 皮膚病診療, Vol.37, No.4, 345-348, 2015.
48.	Tetsuya Hida, Kazutoshi Murao, Mika Oshima, Takeshi Ishigami and Yoshiaki Kubo : A case of pyoderma gangrenosum associated with anterior necrotizing scleritis in a patient with ulcerative colitis., International Journal of Dermatology, Vol.54, No.7, e269-70, 2015. (Keyword) Aged / Colitis, Ulcerative / Humans / Male / Pyoderma Gangrenosum / Scleritis (Link to Publication Site) ● Publication site (DOI): 10.1111/ijd.12791 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25784378 ● Search Scopus @ Elsevier (PMID): 25784378 ● Search Scopus @ Elsevier (DOI): 10.1111/ijd.12791 (DOI: 10.1111/ijd.12791, PubMed: 25784378)
49.	Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : A case of sarcoidosis diagnosed by granulomatous tattoo reactions, Japanese Journal of Clinical Dermatology, Vol.69, No.2, 121-125, 2015. (Keyword) 刺青 / サルコイドーシス (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390283684869498752 (CiNii: 1390283684869498752)
50.	Kazutoshi Murao, Rika Yoshioka and Yoshiaki Kubo : Human papillomavirus infection in Bowen disease: Negative p53 expression, not p16(INK4a) overexpression, is correlated with human papillomavirus-associated Bowen disease, The Journal of Dermatology, Vol.41, No.10, 878-884, 2014. (Summary) Genital Bowen disease (BD) has been linked to the high-risk types of human papillomavirus (HPV) infection. Recently, it has been recognized that HPV also can be associated with extragenital BD. HPV oncoproteins E6 and E7 interfere with the function of p53 and pRb, respectively, leading carcinogenesis. p16(INK4a) overexpression induced by inactivation of pRb is recognized as a surrogate marker for HPV-associated cervical cancer. In this study, we examined the presence of HPV DNA in 142 BD lesions by polymerase chain reaction (PCR), and determined the type of HPV by PCR restriction fragment length polymorphism or direct DNA sequencing. HPV DNA was detected in 66.7% of genital BD and 8.3% of extragenital BD. The types of HPV detected were HPV types 6, 16, 33, 52, 56, 58 and 59. We also investigated the expression of p16(INK4a) , pRb and p53 by immunohistochemistry. Positive expression was detected in 88.6% for p16(INK4a) , 25.2% for pRb, and 63.8% for p53. There was no significant difference in p16(INK4a) and pRb expression between HPV-positive and -negative BD. However, a strong correlation of HPV positivity with p53 negativity was found. A total of 66.7% of HPV-positive BD showed no p53 expression, whereas the corresponding rate was 32.8% of HPV-negative BD. This study demonstrated that HPV can participate in the development of BD, not only in the genital lesion, but also in extragenital lesion. p16(INK) (4a) overexpression is not a marker for HPV infection in BD. Instead, negative p53 expression is correlated with HPV-associated BD. (Link to Publication Site) ● Publication site (DOI): 10.1111/1346-8138.12613 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25201325 ● Summary page in Scopus @ Elsevier: 2-s2.0-84908410065 (DOI: 10.1111/1346-8138.12613, PubMed: 25201325, Elsevier: Scopus)
51.	Mika Oshima, Kazutoshi Murao and Yoshiaki Kubo : エキセナチドの皮下注射部位に生じた薬疹の1例, Hifuka No Rinsho, Vol.56, No.9, 1374-1375, 2014.
52.	山下尚志, Yoshiaki Kubo, 松尾準雄, 佐地勉, 田嶋徹, 和泉梢, 田代淳, 井石秀明 and 河瀬ゆり子 : Cowden病, 皮膚病診療, Vol.36, No.9, 353-356, 2014.
53.	Mika Oshima, 祖川麻衣子, Sugita Takashi, Matsunaka Hiroshi, Murakami Yumi, Saya Yumiko, Yoshihiro Matsudate, Nozomi Fukui, Kazutoshi Murao and Yoshiaki Kubo : Improvement of Scalp Condition and Quality of Life through Proper Skin Care of Dry Scalp, Journal of Cosmetics Dermatological Sciences and Applications, Vol.4, No.4, 284-292, 2014. (Link to Publication Site) ● Publication site (DOI): 10.4236/jcdsa.2014.44038 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.4236/jcdsa.2014.44038 (DOI: 10.4236/jcdsa.2014.44038)
54.	仁木真理子, Yoshihiro Matsudate, Kazutoshi Murao, Yoshiaki Kubo, Ichiro Hashimoto, 柏木圭介, 仙崎雄一 and Hideki Nakanishi : リンパ節転移を伴った mucinous carcinoma of the skin の1例, 臨床皮膚科, Vol.68, No.9, 720-724, 2014.
55.	Tetsuya Hida, Mitsuyoshi Minami, Hidetoshi Kawaguchi, Yumi Oshiro and Yoshiaki Kubo : Case of erythema nodosum associated with granulomatous mastitis probably due to Corynebacterium infection., The Journal of Dermatology, Vol.41, No.9, 821-823, 2014. (Summary) Granulomatous mastitis (GM) is a rare chronic inflammatory breast disease that can be mistaken for a variety of inflammatory and neoplastic disorders of the breast. Erythema nodosum (EN) is a common panniculitis, and is often associated with a variety of diseases, yet coexistence of EN and GM is very rare. In this paper, we present a young Japanese woman with EN associated with GM probably due to Corynebacterium infection. Both lesions of EN and GM were successfully treated with oral minocycline and surgical drainage. To the best of our knowledge, this is the first case of EN associated with GM due to Corynebacterium infection in the English-language published work. (Link to Publication Site) ● Publication site (DOI): 10.1111/1346-8138.12604 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25182294 ● Search Scopus @ Elsevier (PMID): 25182294 ● Search Scopus @ Elsevier (DOI): 10.1111/1346-8138.12604 (DOI: 10.1111/1346-8138.12604, PubMed: 25182294)
56.	Mayu Yuasa, Takeshi Ishigami, Kazutoshi Murao, Yoshiaki Kubo, Yumiko Kotani and Hiroaki Kohno : A case of methylmalonic academia with acrodermatitis enteropathica-like eruption due to essential amino acids deficiency, Japanese Journal of Clinical Dermatology, Vol.68, No.7, 525-529, 2014. (Keyword) メチルマロン酸血症 / 腸性肢端皮膚炎様皮疹 / 必須アミノ酸欠乏 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390565159844814208 (CiNii: 1390565159844814208)
57.	Yoshihiro Matsudate, 仙崎聖子, Kazutoshi Murao, Yoshiaki Kubo and Yasutoshi Hida : A case of ichthyosiform mycosis fungoides, Japanese Journal of Clinical Dermatology, Vol.68, No.6, 453-457, 2014. (Keyword) 魚鱗癬様菌状息肉症 / 後天性魚鱗癬 / 毛包性丘疹 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390002209891348352 (CiNii: 1390002209891348352)
58.	Yutaro Yamashita, Ichiro Hashimoto, Yoshiro Abe, Takuya Seike, Katsumasa Okawa, Yuichi Senzaki, Kazutoshi Murao, Yoshiaki Kubo and Hideki Nakanishi : Effect of the Biopsy Technique on the Survival Rate of Malignant Melanoma Patients, Archives of Plastic Surgery, Vol.41, No.2, 122-125, 2014. (Summary) Cutaneous malignant melanoma has a poor prognosis. The detrimental effect of incisional biopsies on the outcome of malignant melanoma has been debated. The aim of this study was to determine the effect of the presence and type of biopsy on the prognosis of malignant melanoma. The medical records of 109 malignant melanoma patients treated at Tokushima University Hospital from 1983 to 2007 were reviewed. After excluding 28 cases with stage 0 disease or incomplete data, 81 cases were analyzed in detail with respect to patient sex, age, tumor site, clinical stage at diagnosis, presence of ulceration or lymph node metastasis, and prognosis. The five-year survival and five-year disease-free survival rates of patients who underwent incisional or excisional biopsies were compared with those who did not undergo a biopsy. The male-to-female ratio was 1:1.19. The mean age was 61.3 years (range, 19-93 years). The most common site was a lower extremity, and the most common clinical stage was stage II. No significant differences in clinicopathological features, five-year survival rates, and five-year disease-free survival rates were observed among the three groups. The presence and type of biopsy neither affected the metastatic rate nor the prognosis of malignant melanoma. The use of incisional biopsies is not encouraged because tumor thickness cannot be measured accurately. However, they may be helpful for confirming the diagnosis if an excisional biopsy cannot be performed. (Tokushima University Institutional Repository) ● Metadata: 114286 (Link to Publication Site) ● Publication site (DOI): 10.5999/aps.2014.41.2.122 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24665419 ● Summary page in Scopus @ Elsevier: 2-s2.0-84896446893 (Tokushima University Institutional Repository: 114286, DOI: 10.5999/aps.2014.41.2.122, PubMed: 24665419, Elsevier: Scopus)
59.	Kazutoshi Murao, Osamu Miyajima and Yoshiaki Kubo : Woolly hair nevus associated with digital abnormalities and auditory disturbance., International Journal of Dermatology, Vol.53, No.3, e164-e166, 2014. (Keyword) Female / Fingers / Hair Diseases / Hand Deformities, Congenital / Hearing Disorders / Humans / Infant (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1365-4632.2012.05819.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23621149 ● Search Scopus @ Elsevier (PMID): 23621149 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1365-4632.2012.05819.x (DOI: 10.1111/j.1365-4632.2012.05819.x, PubMed: 23621149)
60.	仙崎聖子, 仁木真理子, Kazutoshi Murao, Yoshiaki Kubo, Yoshihisa Sakao and 高橋収 : CASE REPORTS : Two Cases of Contact Dermatitis Due to Hair Dyes, Hifuka No Rinsho, Vol.56, No.3, 403-407, 2014. (Keyword) 接触皮膚炎 / ヘアダイ / 酸化染毛剤 / インディゴ (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522825130424790528 (CiNii: 1522825130424790528)
61.	Yoshibumi Shimizu, Kazutoshi Murao, Tamotsu Tanaka, Yoshiaki Kubo and Akira Tokumura : Increased lysophospholipase D activity of autotaxin in sera of patients with atopic dermatitis., Journal of Dermatological Science, Vol.74, No.2, 162-165, 2014. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jdermsci.2014.01.010 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24582488 ● Summary page in Scopus @ Elsevier: 2-s2.0-84897115979 (DOI: 10.1016/j.jdermsci.2014.01.010, PubMed: 24582488, Elsevier: Scopus)
62.	Nozomi Fukui, Yoshiaki Kubo, Kenji Hirose and 他4名 : 悪性腫瘍を合併した抗155/140kDaタンパク抗体陽性皮膚筋炎の2例, Hifuka No Rinsho, Vol.56, No.2, 161-165, 2014.
63.	Maki Hosoki, Toyoko Tajima, Keisuke Nishigawa, Hisahiro Takeuchi, Yoshizo Matsuka and Yoshiaki Kubo : Potential Risk of Metal Allergy Associated with Pierced Earrings Containing Nickel, Journal of Environmental Dermatology and Cutaneous Allergology, Vol.8, No.1, 12-20, 2014. (Keyword) 金属アレルギー / ピアス / ニッケル / 金属元素分析 / metal allergy / pierced earring / nickel / elemental analysis (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520010381212751872 (CiNii: 1520010381212751872)
64.	Yoshiaki Kubo : 母斑症・遺伝性疾患高発癌性遺伝性疾患の概要と最近の知見, The Japanese Journal of Dermatology, Vol.123, No.13, 2813-2815, 2013. (Keyword) 過誤腫症候群-多発性(診断); 基底細胞母斑症候群(診断); 変異; 腫瘍過程; 母斑(診断); 遺伝学的検査; PTEN Phosphatase / *発癌 / Homo sapiens (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520009409321449216 (CiNii: 1520009409321449216)
65.	仁木真理子, Kazutoshi Murao, Tomoya Mizutani and Yoshiaki Kubo : Xanthomas Associated with Primary Biliary Cirrhosis, Hifuka No Rinsho, Vol.55, No.13, 1879-1882, 2013. (Keyword) 黄色腫 / 原発性胆汁性肝硬変 / 小結節型 / 手掌線条型 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521417755939321472 (CiNii: 1521417755939321472)
66.	Yoshihiro Matsudate, 仁木真理子, Kazutoshi Murao and Yoshiaki Kubo : A case of livedo vasculopathy successfully treated with dabigatran, Japanese Journal of Clinical Dermatology, Vol.67, No.10, 759-763, 2013. (Keyword) リベド血管症 / ダビガトラン / 脳出血 / 下腿潰瘍 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390565159845609344 (CiNii: 1390565159845609344)
67.	Takeshi Ishigami, Kazuhiro Furukita, Kazutoshi Murao and Yoshiaki Kubo : A Case of Leg Ulcers due to Juvenile-onset Deep Venous Thrombosis of the Leg Associated with Congenital Stenosis of the Inferior Vena Cava, The Nishinihon Journal of Dermatology, Vol.75, No.4, 301-303, 2013. (Link to Publication Site) ● Publication site (DOI): 10.2336/nishinihonhifu.75.301 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679278619520 ● Summary page in Scopus @ Elsevier: 2-s2.0-84888146242 (DOI: 10.2336/nishinihonhifu.75.301, CiNii: 1390282679278619520, Elsevier: Scopus)
68.	Mika Oshima, Yasutoshi Hida, 武市浩美, Kazutoshi Murao and Yoshiaki Kubo : Cutaneous Alternariosis on the Face Successfully Treated with a Combination of Terbinafine and Topical Heat Therapy, Hifuka No Rinsho, Vol.55, No.8, 982-985, 2013. (Keyword) アルテルナリア / 黒色真菌 / 局所温熱療法 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520573330552707200 (CiNii: 1520573330552707200)
69.	Kazutoshi Murao, Mayu Yuasa, Takeshi Ishigami, Yoshiaki Kubo and Seiji Arase : Bowen disease of the palm associated with human papillomavirus 52., Clinical and Experimental Dermatology, Vol.38, No.5, 489-491, 2013. (Summary) Human papillomavirus (HPV) is a well-known risk factor for many human cancers, especially cervical cancers. Among the nonmelanoma skin cancers, Bowen disease (BD) of the genitalia and fingers has also been shown to be closely associated with the high-risk types of HPV, especially HPV16. We report a case of BD of the palm, which is a very rare location for BD. In addition to its rare location, HPV52, which is classified as a mucous high-risk HPV type, was detected in the lesion by PCR restriction fragment length polymorphism analysis. To our knowledge, this is the first reported case of BD associated with HPV52. (Keyword) Aged / Bowen's Disease / Female / Hand Dermatoses / Humans / Papillomaviridae / Papillomavirus Infections / Rare Diseases / Skin Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1365-2230.2012.04382.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23659186 ● Search Scopus @ Elsevier (PMID): 23659186 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1365-2230.2012.04382.x (DOI: 10.1111/j.1365-2230.2012.04382.x, PubMed: 23659186)
70.	五十嵐愛子, 畑郁江, 林泰平, 川谷正男, 大嶋勇成, 眞弓光文 and Yoshiaki Kubo : Various Vascular Lesions in a Girl with Bannayan-Riley-Ruvalcaba Syndrome, The Journal of the Japan Pediatric Society, Vol.117, No.5, 868-871, 2013. (Keyword) 過誤腫症候群-多発性(合併症); 肝臓疾患(病因,X線診断); 肝動脈(X線診断); 血管疾患(病因,X線診断); 血管瘻(病因,X線診断); X線CT; 動静脈瘻(病因,X線診断); 動脈瘤(病因,X線診断); 変異; 門脈(X線診断); 血管脂肪腫(病因,X線診断); PTEN Phosphatase / *Bannayan-Zonana症候群(合併症); 肝内短絡路(病因,X線診断); 腹部CT / ヒト; 青年期(13∼18); 女 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520009408853154560 (CiNii: 1520009408853154560)
71.	Tomoya Mizutani, Natsuko Inoue, Kazutoshi Murao, Yoshiaki Kubo and Osamu Takahashi : Hypomelanosis of Ito: A Case of Definitive Diagnosis without any Extracutaneous Complication at First Medical Examination and a Case of Presumptive Diagnosis, Hifuka No Rinsho, Vol.55, No.5, 576-579, 2013.
72.	Muhammad Farooq, Hiroki Fujikawa, Atsushi Fujimoto, Yoshiaki Kubo, Masaaki Ito and Yutaka Shimomura : A novel de novo nonsense mutation in the TRPS1 gene in a Japanese patient with tricho-rhino-phalangeal syndrome type I., International Journal of Dermatology, Vol.53, No.8, 1012-1015, 2013. (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1365-4632.2012.05694.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23621477 ● Search Scopus @ Elsevier (PMID): 23621477 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1365-4632.2012.05694.x (DOI: 10.1111/j.1365-4632.2012.05694.x, PubMed: 23621477)
73.	Osamu Miyajima, Kazutoshi Murao, Yoshiaki Kubo and Kyoko Takeuchi : B細胞リンパ腫に合併したbullous amyloidosis, 皮膚病診療, Vol.35, No.4, 387-390, 2013.
74.	Kazutoshi Murao, Yasushi Sadamoto, Yoshiaki Kubo and Seiji Arase : Generalized malignant acanthosis nigricans with "deck-chair sign"., International Journal of Dermatology, Vol.52, No.3, 377-378, 2013. (Keyword) Acanthosis Nigricans / Adenocarcinoma / Aged / Fatal Outcome / Female / Gastrectomy / Humans / Lymph Node Excision / Parapsoriasis / Splenectomy / Stomach Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1365-4632.2011.04915.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23414165 ● Summary page in Scopus @ Elsevier: 2-s2.0-84873975793 (DOI: 10.1111/j.1365-4632.2011.04915.x, PubMed: 23414165, Elsevier: Scopus)
75.	緋田哲也, Yoshihiro Matsudate, Kazutoshi Murao, Yoshiaki Kubo and Yasutoshi Hida : A case of Bowen's disease arising in a region of seborrheic keratosis, Skin Cancer, Vol.28, No.2, 181-184, 2013. (Summary) A 73-year-old Japanese woman was referred to our hospital because of a left leg skin tumor which was gradually growing. Clinical examination revealed a 14 × 13mm brownish keratotic plaque on her leg. Since an excisional biopsy specimen taken by a local dermatologist suggested squamous cell carcinoma, we performed an excisional biopsy. Histologically, the lesion consisted of proliferating keratinocytes. The periphery of the tumor showed reticulated seborrheic keratosis ; whereas in the center portion of the tumor, tumor cells consisted of atypical keratinocytes in the entire epidermis which was considered to be Bowen's disease. We should keep in mind that although rare, skin cancer, including Bowen's disease, could arise in a lesion of seborrheic keratosis.[Skin Cancer (Japan) 2013 ; 28 : 181-184] (Keyword) Seborrheic keratosis / Bowen's disease (Link to Publication Site) ● Publication site (DOI): 10.5227/skincancer.28.181 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204335187840 ● Search Scopus @ Elsevier (DOI): 10.5227/skincancer.28.181 (DOI: 10.5227/skincancer.28.181, CiNii: 1390001204335187840)
76.	Takeshi Ishigami, Yasutoshi Hida, Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : The involvement of fibroblast growth factor receptor signaling pathways in dermatofibroma and dermatofibrosarcoma protuberans., The Journal of Medical Investigation : JMI, Vol.60, No.1-2, 106-113, 2013. (Summary) Fibroblast growth factors (FGFs) and their receptors (FGFRs) control a wide range of biological functions; however, their involvement in the pathogenesis of dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) is currently unknown. In this study, we first confirmed the histological diagnosis by detecting fusion COL1A1-PDGFB transcripts in DFSP, and examined the expression of all FGFRs (FGFR1-4), some of their ligands (FGF1, 2, 9), and forkhead box N1 (FOXN1) as a downstream target of FGFR3 in DF and DFSP by immunohistochemical analysis. Although we failed to detect the expression of FGF1 and FGF9 as specific ligands for FGFR3 in DF, overexpression of FGFR3 and FOXN1 was observed in the epidermal regions of DF, suggesting that the epidermal regions of DF were similar to seborrhoeic keratosis both in terms of histological features and the activation of FGFR3/FOXN1. In addition, strong expression of FGF2 and FGFR4 was observed in the tumor lesions of DF. Expression patterns of FGFR3/FOXN1 and FGF2/FGFR4 in DF were in contrast with those of DFSP. The activation of FGFR signaling pathways may be not only relevant to the pathogenesis of DF, but also very useful in the differential diagnosis of DF and DFSP. (Keyword) Adult / Aged / Collagen Type I / Dermatofibrosarcoma / Female / Forkhead Transcription Factors / Genes, sis / Histiocytoma, Benign Fibrous / Humans / Male / Middle Aged / Receptors, Fibroblast Growth Factor / Signal Transduction (Tokushima University Institutional Repository) ● Metadata: 106044 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.60.106 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23614918 ● Summary page in Scopus @ Elsevier: 2-s2.0-84876059149 (Tokushima University Institutional Repository: 106044, DOI: 10.2152/jmi.60.106, PubMed: 23614918, Elsevier: Scopus)
77.	Mika Oshima, Kazutoshi Murao, Takeshi Ishigami and Yoshiaki Kubo : Drug eruption induced by gonadotropin-releasing hormone analogs accompanying radiation-recall phenomenon., The Journal of Dermatology, Vol.39, No.12, 1080-1081, 2012. (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1346-8138.2012.01576.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22568476 ● Search Scopus @ Elsevier (PMID): 22568476 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1346-8138.2012.01576.x (DOI: 10.1111/j.1346-8138.2012.01576.x, PubMed: 22568476)
78.	仙崎聖子, Kenji Hirose, Takeshi Ishigami, Kazutoshi Murao, Yoshiaki Kubo and Yasuhiko Nishioka : Two cases of photosensitive drug eruption due to pirfenidone, Japanese Journal of Clinical Dermatology, Vol.66, No.12, 945-948, 2012. (Keyword) ピルフェニドン / 光線過敏症 / 光毒性 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390283684869687680 (CiNii: 1390283684869687680)
79.	Maki Hosoki, Toyoko Satsuma, Keisuke Nishigawa, Hisahiro Takeuchi and Yoshiaki Kubo : Causal Effect of Earrings for Pierced Ears on Dental Metal Allergy, Journal of Environmental Dermatology and Cutaneous Allergology, Vol.6, No.4, 359-367, 2012. (Keyword) metal allergy / earring / patch test / elemental analysis / nickel (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520573331166903936 (CiNii: 1520573331166903936)
80.	Kazutoshi Murao, Daisuke Fukumoto and Yoshiaki Kubo : Squamous cell carcinoma of the scalp associated with human papillomavirus type 16., European Journal of Dermatology : EJD, Vol.21, No.6, 1005-1006, 2011. (Keyword) Aged, 80 and over / DNA, Viral / Female / Head and Neck Neoplasms / Human papillomavirus 16 / Humans / Immunohistochemistry / Papillomavirus Infections / Polymerase Chain Reaction / Scalp / Skin Diseases (Link to Publication Site) ● Publication site (DOI): 10.1684/ejd.2011.1520 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21896422 ● Search Scopus @ Elsevier (PMID): 21896422 ● Search Scopus @ Elsevier (DOI): 10.1684/ejd.2011.1520 (DOI: 10.1684/ejd.2011.1520, PubMed: 21896422)
81.	Daisuke Fukumoto, Shin-ichi Ansai, 福本実扶子, Yoshiaki Kubo, Seiji Arase and Hideki Nakanishi : A clinicopathological study of primary cutaneous invasive squamous cell carcinoma: relationship between a new clinicopathological classification and program, The Japanese Journal of Dermatology, Vol.121, No.11, 2247-2255, 2011. (Summary) We performed a clinicopathological analysis of 305 cases of primary cutaneous invasive squamous cell carcinoma (SCC) diagnosed in Tokushima University hospital in the past 25 years. We proposed a new clinicopathological classification of SCC based on epidemiological factors and divided it into nine categories; actinic keratosis type, bowen type, keratoacanthomatous type, cystic type, genital type, cicatricial type, radiodermatitis type, xeroderma pigmentosa type, and miscellaneous type. We examined the clinicopathological characteristics in each category such as favorite locations and prognosis. Among the clinical characteristics of those cases, such as sex ratio and age at the time of the excision, the favorite sites were similar to those in former reports in Japan. The actinic keratosis type is a significant type with little metastasis, but the radiodermatitis type and the genital type showed high metastatic rates. The case that occurred on the face showed little metastasis, but the cases on the lower limbs and genitalia had high metastatic rates. Cases with a tumor thickness of less than 4 mm showed lower metastatic rates than those with a tumor thickness of more than 4 mm. We divided those 25 years into five year segments as investigation periods and examined the numbers of cases, sex ratios, and the frequencies of the actinic keratosis type, the Bowen disease type, and the other types and found that these factors were essentially equal. (Keyword) Squamous cell carcinoma / SCC / Clinicopathological study (Link to Publication Site) ● Publication site (DOI): 10.14924/dermatol.121.2247 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205736351744 ● Search Scopus @ Elsevier (DOI): 10.14924/dermatol.121.2247 (DOI: 10.14924/dermatol.121.2247, CiNii: 1390001205736351744)
82.	Kazutoshi Murao, Yasutoshi Hida, Mayumi Minato, Yoshiaki Kubo and Seiji Arase : Relapsing polychondritis associated with psoriasis vulgaris and alopecia areata., European Journal of Dermatology : EJD, Vol.21, No.5, 779-780, 2011. (Keyword) Adult / Alopecia Areata / Autoimmune Diseases / Female / Humans / Polychondritis, Relapsing / Psoriasis (Link to Publication Site) ● Publication site (DOI): 10.1684/ejd.2011.1437 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21697067 ● Search Scopus @ Elsevier (PMID): 21697067 ● Search Scopus @ Elsevier (DOI): 10.1684/ejd.2011.1437 (DOI: 10.1684/ejd.2011.1437, PubMed: 21697067)
83.	Yoshiaki Kubo, Yoshio Urano, Rie Matsuda, Takeshi Ishigami, Kazutoshi Murao, Seiji Arase and Akemi Ishida-Yamamoto : Ichthyosis hystrix, Curth-Macklin type: a new sporadic case with a novel mutation of keratin 1., Archives of Dermatology, Vol.147, No.8, 999-1001, 2011. (Keyword) Child, Preschool / Dermatitis, Seborrheic / Humans / Ichthyosis / Keratin-1 / Male / Mutation (Link to Publication Site) ● Publication site (DOI): 10.1001/archdermatol.2011.217 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21844476 ● Search Scopus @ Elsevier (PMID): 21844476 ● Search Scopus @ Elsevier (DOI): 10.1001/archdermatol.2011.217 (DOI: 10.1001/archdermatol.2011.217, PubMed: 21844476)
84.	M Fukumoto, Kazutoshi Murao, Hiroyoshi Watanabe, Yoshiaki Kubo and Seiji Arase : Generalized hypopigmented macules after bone-marrow transplantation., Clinical and Experimental Dermatology, Vol.36, No.7, 803-804, 2011. (Keyword) Bone Marrow Transplantation / Child / Humans / Hypopigmentation / Male / Melanocytes / Postoperative Complications (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1365-2230.2011.04044.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21575040 ● Search Scopus @ Elsevier (PMID): 21575040 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1365-2230.2011.04044.x (DOI: 10.1111/j.1365-2230.2011.04044.x, PubMed: 21575040)
85.	Mio Machida, Yasutoshi Hida, Yoshiaki Kubo, Seiji Arase and 安齋眞一 : Clinical case reports: Coexistence of low-grade sebaceous carcinoma and basal cell carcinoma in a nevus sebaceous, The Nishinihon Journal of Dermatology, Vol.73, No.2, 152-156, 2011. (Summary) A 60-year-old Japanese man visited our outpatient clinic complaining of a black protruding tumor on his left cheek with a 3-year history. The tumor arose in a pre-existing skin-colored plaque that had been noticed since his childhood. We suspected a basal cell carcinoma (BCC) arising in a nevus sebaceus (NS), and excised the lesion including the NS. A histopathological examination of the whole specimen demonstrated the coexistence of a low-grade sebaceous carcinoma (low-grade SC) and BCC in an NS. An NS is classified into three progression stages, and various types of epithelial tumors occur secondarily in the lesion at the third stage, especially when patients are more than 50 years old. Among those secondary malignant tumors, BCC is the most common, and SC is rather rare. We reviewed the literature and summarized 31 cases of malignant sebaceous tumors arising in an NS, focusing on clinical characteristics. Surprisingly, seven cases had other malignant tumors, most of which were BCC as in our case. Only one patient with SC in an NS died from metastasis, and another 30 cases were cured after appropriate treatments. Therefore, we suggest that SC in an NS is curable by careful extirpation, although the prognosis of common SC is rather poor. But seen on the background of this case the concept of `low-grade SC' should be kept in mind. (Keyword) Dermatology (Link to Publication Site) ● Publication site (DOI): 10.2336/nishinihonhifu.73.152 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204299071488 ● Summary page in Scopus @ Elsevier: 2-s2.0-79955811506 (DOI: 10.2336/nishinihonhifu.73.152, CiNii: 1390001204299071488, Elsevier: Scopus)
86.	Takeshi Ishigami, Yoshiaki Kubo, Yoshihiro Matsudate, Shin-ichi Ansai, Seiji Arase, Bungo Ohyama and Takashi Hashimoto : Paraneoplastic pemphigus associated with non-Hodgkin's lymphoma., European Journal of Dermatology : EJD, Vol.21, No.1, 122-124, 2011. (Keyword) Antibodies, Monoclonal, Murine-Derived / Antineoplastic Agents / Antineoplastic Combined Chemotherapy Protocols / Cyclophosphamide / Doxorubicin / Fatal Outcome / Female / Fluorescent Antibody Technique, Direct / Glucocorticoids / Humans / Immunoblotting / Lymphoma, Non-Hodgkin / Middle Aged / Paraneoplastic Syndromes / Pemphigus / Prednisolone / Vincristine (Link to Publication Site) ● Publication site (DOI): 10.1684/ejd.2010.1182 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21190909 ● Search Scopus @ Elsevier (PMID): 21190909 ● Search Scopus @ Elsevier (DOI): 10.1684/ejd.2010.1182 (DOI: 10.1684/ejd.2010.1182, PubMed: 21190909)
87.	Sachiko Takeichi, Yoshiaki Kubo, Kazutoshi Murao, Natsuko Inoue, Shin-ichi Ansai and Seiji Arase : Coexistence of giant blue nevus of the scalp with hair loss and alopecia areata., The Journal of Dermatology, Vol.38, No.4, 377-381, 2010. (Summary) A 43-year-old Japanese man presented with a 13-year history of a grayish macule measuring 7 cm in diameter with sparse hairs on the vertex. Histopathological examination demonstrated two types of melanocytes, spindle-shaped and ovoid cells, with abundant melanin aggregated around the upper part of the pilosebaceous apparatus. Fibrous, thick collagen bundles were also seen surrounding the upper part of the small hair follicles. There was no infiltration of melanocytes or lymphocytes in the lower dermis or adipose tissue. Based on these findings, a diagnosis of blue nevus, cellular type, was made. Giant cellular blue nevi on the scalp are rare, and 11 cases reported in the published work have shown characteristic features such as hair loss and cranial invasion of nevus cells. It should be noted that melanocytes of giant blue nevi have a high potential to damage other organs such as underlying bone and hair follicles. The patient also showed a typical lesion of alopecia areata on the left temporal which was successfully treated with topical corticosteroid. (Keyword) Adult / Alopecia Areata / Humans / Male / Nevus, Blue / Scalp / Skin Neoplasms / Tomography, X-Ray Computed (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1346-8138.2010.01020.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21352287 ● Search Scopus @ Elsevier (PMID): 21352287 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1346-8138.2010.01020.x (DOI: 10.1111/j.1346-8138.2010.01020.x, PubMed: 21352287)
88.	井上奈津子, Daisuke Fukumoto, Yoshiaki Kubo, Seiji Arase and 藤山幹子 : ラモトリギンによるStevens-Johnson症候群の1例, Hifuka No Rinsho, Vol.52, No.10, 1486-1487, 2010. (Keyword) Methylprednisolone(治療的利用)
89.	Kenji Hirose, Yasutoshi Hida, Shin-ichi Ansai, Yoshiaki Kubo, Seiji Arase and 高橋収 : Scalp angiosarcoma successfully treated with weekly docetaxel and linac electron beam, Hifuka No Rinsho, Vol.52, No.10, 1477-1480, 2010. (Keyword) *血管肉腫(病理学,薬物療法,放射線療法) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522262180531965568 (CiNii: 1522262180531965568)
90.	Mio Machida, Shin-ichi Ansai, Yasutoshi Hida, Yoshiaki Kubo, Seiji Arase and Ken Kuramoto : Basal cell carcinoma arising on the palm., The Journal of Dermatology, Vol.38, No.1, 94-96, 2010. (Keyword) Aged / Carcinoma, Basal Cell / Dermoscopy / Female / Humans / Skin Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1346-8138.2010.00997.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21175764 ● CiNii @ National Institute of Informatics (CRID): 1573387451024877824 ● Search Scopus @ Elsevier (PMID): 21175764 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1346-8138.2010.00997.x (DOI: 10.1111/j.1346-8138.2010.00997.x, PubMed: 21175764, CiNii: 1573387451024877824)
91.	Yoshiaki Kubo, Daisuke Fukumoto, Takeshi Ishigami, Yasutoshi Hida and Seiji Arase : Diltiazem-associated photodistributed hyperpigmentation: report of two Japanese cases and published work review., The Journal of Dermatology, Vol.37, No.9, 807-811, 2010. (Summary) Scherschum et al. proposed diltiazem-associated photodistributed hyperpigmentation as a novel type of drug-induced photosensitive lichenoid eruption. The characteristic clinical features were slate-gray reticulated hyperpigmentation on sun-exposed areas, while lichenoid dermatitis with prominent pigmentary incontinence was noted histologically. Although the clinical and histological features were similar to those of lichen planus pigmentosus, the histological features did not show either compact hyperkeratosis or wedge-shaped hypergranulosis, which are typical histological features of lichen planus. We describe two Japanese cases of diltiazem-associated photodistributed hyperpigmentation, who were successfully treated with topical tacrolimus, and review the published work. (Keyword) Aged, 80 and over / Asian Continental Ancestry Group / Calcium Channel Blockers / Diltiazem / Drug Eruptions / Female / Humans / Hyperpigmentation / Japan / Photosensitivity Disorders / Tacrolimus / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1346-8138.2010.00858.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20883365 ● Search Scopus @ Elsevier (PMID): 20883365 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1346-8138.2010.00858.x (DOI: 10.1111/j.1346-8138.2010.00858.x, PubMed: 20883365)
92.	Kenji Hirose, Yoshiaki Kubo, Toshinori Noda, Seiji Arase, 牧野英記, Aki Endo and 宇都宮正裕 : 嚥下障害を伴った皮膚筋炎に対し免疫グロブリン大量療法(IVIG)が奏効した2例, The Nishinihon Journal of Dermatology, Vol.72, No.4, 344-348, 2010. (Keyword) *IgG(治療的利用) (Link to Publication Site) ● Publication site (DOI): 10.2336/nishinihonhifu.72.344 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679277184000 ● Summary page in Scopus @ Elsevier: 2-s2.0-77956298321 (DOI: 10.2336/nishinihonhifu.72.344, CiNii: 1390282679277184000, Elsevier: Scopus)
93.	Kazuya Matsumoto, Ichiro Hashimoto, Hideki Nakanishi, Yoshiaki Kubo, Kazutoshi Murao and Seiji Arase : Resin splint as a new conservative treatment for ingrown toenails., The Journal of Medical Investigation : JMI, Vol.57, No.3-4, 321-325, 2010. (Summary) Several conservative as well as surgical methods are used for the treatment of ingrown toenails until date. The conservative methods are either based on nail splinting or on orthonyxia, but no methods employing both principles have been reported thus far. Moreover, surgical methods usually involve postoperative pain, prolonged wound healing and restricted activities of daily living. Therefore, considering the need of a simplified, non-invasive method, in this study, we applied a novel splint to treat patients with ingrown toenails and estimated the clinical efficacy as well as rate of recurrence following treatment. The splint is a plate made of resin that is attached to the lateral edge of the nail using a bandage. We studied 61 patients (19 men and 42 women; mean age 36 years), with an average application duration of 9.3 months and an average follow-up period of 10 months in all patients. All patients experienced pain relief within a week of splint application and a decrease in the degree of nail deformity. Moreover, follow-up revealed a recurrence rate of 8.2%. Therefore, we believe that this new device is an excellent conservative treatment method for patients with ingrown toenails. (Keyword) Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle Aged / Nails, Ingrown / Orthotic Devices / Pain / Resins, Synthetic / Retrospective Studies / Splints / Young Adult (Tokushima University Institutional Repository) ● Metadata: 79330 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.57.321 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20847533 ● Search Scopus @ Elsevier (PMID): 20847533 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.57.321 (Tokushima University Institutional Repository: 79330, DOI: 10.2152/jmi.57.321, PubMed: 20847533)
94.	安芸実扶子, Yoshiaki Kubo, Minako Saito, Daisuke Fukumoto and Seiji Arase : 【肉芽腫症】右環指の腫脹を契機に診断したサルコイドーシスの1例, Hifuka No Rinsho, Vol.52, No.8, 1057-1060, 2010. (Keyword) Allopurinol(治療的利用) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1524232504932196096 (CiNii: 1524232504932196096)
95.	Mio Machida, Takeshi Ishigami, Shin-ichi Ansai, Yoshiaki Kubo, 藤山幹子 and Seiji Arase : 硫酸クロピドグレルによる薬剤性過敏症症候群の1例, Hifuka No Rinsho, Vol.52, No.8, 1115-1119, 2010. (Keyword) Prednisolone(治療的利用) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1523669553242766208 (CiNii: 1523669553242766208)
96.	Sachiko Takeichi, Shin-ichi Ansai, Yoshiaki Kubo and Seiji Arase : 60年以上続くリンパ浮腫肢に生じた脈管肉腫の1例, Hifuka No Rinsho, Vol.52, No.6, 885-888, 2010. (Keyword) *血管肉腫(病理学,合併症) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522262180240488576 (CiNii: 1522262180240488576)
97.	Kazuhiro Furukita, Yoshiaki Kubo, Daisuke Fukumoto, Yasutoshi Hida, Seiji Arase and Koji Fujita : Isaacs症候群を合併し難治であったびまん性筋膜炎の1例, Hifuka No Rinsho, Vol.52, No.3, 413-417, 2010. (Keyword) 筋電図 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522825130223060992 (CiNii: 1522825130223060992)
98.	原田勝博, Yasutoshi Hida, Yoshiaki Kubo, Shin-ichi Ansai, Seiji Arase, 郷司彩, Yoshihiro Touda and Kenji Mori : 滑脳症を伴ったHypomelanosis of Itoの1例, Hifuka No Rinsho, Vol.52, No.3, 429-431, 2010. (Keyword) *色素異常症(合併症,診断) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520010380961087616 (CiNii: 1520010380961087616)
99.	Daisuke Fukumoto, Shin-ichi Ansai, Yoshiaki Kubo, Kenji Hirose, Yoshihiro Matsudate, 浦野芳夫 and Seiji Arase : Clinicopathological Study of Drug-induced Hypersensitivity Syndrome (DIHS), The Japanese Journal of Dermatology, Vol.120, No.1, 23-29, 2010. (Keyword) *Carbamazepine(治療的利用,毒性・副作用) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680712609920 (CiNii: 1390282680712609920)
100.	井上奈津子, Yoshiaki Kubo, Daisuke Fukumoto, Tadamasa Yamamoto, Shin-ichi Ansai, 山崎雅英 and Seiji Arase : 【血管炎・血行障害】片側の指端壊死で発症した混合性結合組織病続発の抗リン脂質抗体症候群, Hifuka No Rinsho, Vol.52, No.1, 67-70, 2010. (Keyword) Alprostadil(治療的利用) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520573330167168640 (CiNii: 1520573330167168640)
101.	原田勝博, Yoshiaki Kubo, 飛田泰斗史, 内藤史子, 安齋眞一, 荒瀬誠治, 藤本篤夫 and 大浦一 : ペグインターフェロンの皮下注射部に生じた皮膚潰瘍, Hifuka No Rinsho, Vol.52, No.1, 111-114, 2010. (Keyword) Ribavirin(治療的利用) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521417754923277312 (CiNii: 1521417754923277312)
102.	Kazuya Matsumoto, Ichiro Hashimoto, Shinji Matsuo, Hideki Nakanishi, Yoshiaki Kubo, Kazutoshi Murao and Seiji Arase : Prevention of pressure ulcers in home care patients, Shikoku Acta Medica, Vol.65, No.5.6, 137-140, 2009. (Summary) A large proportion of home care patients are at risk of pressure ulcer. The occurrence rate of pressure ulcer is higher in home care patients than that in the patients of hospitals and welfare facilities. The home care patients need long-term conservative treatment because of the depth of the pressure ulcers.Treatment of the pressure ulcers at home results in increase of caregivers burden. Therefore,prevention and early detection of pressure ulcers are important in home nursing. In early stage of pressure ulcers，``deep tissue injury''should be taken into consideration because of its progressive nature. It is a new concept which presents deep tissue damage remaining superficial skin intact.One of clinical features in this condition is induration in a deep layer.The past decade has seen a huge growth in the application of pressure relieving mattresses,absorbent products for urinary and faecal incontinence, and skin barrier products to prevention of the pressure ulcers. Economical, physical, and psychological burden of nursing at home should be decreased with an accumulation of these information and utilization of the products. Therefore, it is important for caregivers to consult with their care managers and acquire new knowledge and information. (Keyword) pressure sore / skin care / deep tissue injury / caregivers (Tokushima University Institutional Repository) ● Metadata: 110292 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050845762395225344 (Tokushima University Institutional Repository: 110292, CiNii: 1050845762395225344)
103.	Daisuke Fukumoto, Yoshiaki Kubo, Minako Saito and Seiji Arase : Centrifugal lipodystrophy of the scalp presenting with an arch-form alopecia: a 10-year follow-up observation., The Journal of Dermatology, Vol.36, No.9, 499-503, 2009. (Summary) We describe a 10-year follow-up observation of progressive arch-form alopecia caused by centrifugal lipodystrophy (CLD) in a Japanese boy. A 2.5-year-old boy developed a slightly depressed lesion demarcated by a horseshoe-shaped erythematous border on his right neck, which then extended to the scalp. Four years later, arch-form alopecia became apparent in the right temporal region along with an erythematous border. The arch-form alopecia gradually expanded centrifugally, leaving a slight residual depression, but hair regrowth was seen within the area of alopecia. Histological examination of the erythematous border revealed non-specific inflammatory changes in the subcutaneous fat. Magnetic resonance imaging findings revealed a loss of subcutaneous fat inside the lesion. The alopecia continuously extended until he was 12 years old, but, thereafter, expansion ceased and hair regrowth gradually occurred in the arch-form alopecia. A linear non-hairy lesion 5 cm in length still remained when he was 13 years old. CLD might involve the scalp and cause linear, arch-form alopecia. (Keyword) Adolescent / Age Factors / Alopecia / Histiocytes / Humans / Lipodystrophy / Lymphocytes / Magnetic Resonance Imaging / Male / Panniculitis / Scalp Dermatoses (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1346-8138.2009.00685.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19712277 ● Search Scopus @ Elsevier (PMID): 19712277 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1346-8138.2009.00685.x (DOI: 10.1111/j.1346-8138.2009.00685.x, PubMed: 19712277)
104.	Kimi Yamakoshi, Akiko Takahashi, Fumiko Hirota, Rika Nakayama, Naozumi Ishimaru, Yoshiaki Kubo, J. David Mann, Masako Ohmura, Atsushi Hirao, Hideyuki Saya, Seiji Arase, Yoshio Hayashi, Kazuki Nakao, Mitsuru Matsumoto, Naoko Ohtani and Eiji Hara : Real-time in vivo imaging of p16Ink4a reveals cross-talk with p53, The Journal of Cell Biology, Vol.186, No.3, 393-407, 2009. (Summary) Expression of the p16(Ink4a) tumor suppressor gene, a sensor of oncogenic stress, is up-regulated by a variety of potentially oncogenic stimuli in cultured primary cells. However, because p16(Ink4a) expression is also induced by tissue culture stress, physiological mechanisms regulating p16(Ink4a) expression remain unclear. To eliminate any potential problems arising from tissue culture-imposed stress, we used bioluminescence imaging for noninvasive and real-time analysis of p16(Ink4a) expression under various physiological conditions in living mice. In this study, we show that oncogenic insults such as ras activation provoke epigenetic derepression of p16(Ink4a) expression through reduction of DNMT1 (DNA methyl transferase 1) levels as a DNA damage response in vivo. This pathway is accelerated in the absence of p53, indicating that p53 normally holds the p16(Ink4a) response in check. These results unveil a backup tumor suppressor role for p16(Ink4a) in the event of p53 inactivation, expanding our understanding of how p16(Ink4a) expression is regulated in vivo. (Keyword) Animals / Cells, Cultured / Cyclin-Dependent Kinase Inhibitor p16 / Disease Models, Animal / Gene Expression Profiling / Humans / Mice / Mice, Inbred C57BL / Mice, Knockout / Mice, Transgenic / Reverse Transcriptase Polymerase Chain Reaction / Time Factors / Tumor Suppressor Protein p53 (Link to Publication Site) ● Publication site (DOI): 10.1083/jcb.200904105 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19667129 ● Search Scopus @ Elsevier (PMID): 19667129 ● Search Scopus @ Elsevier (DOI): 10.1083/jcb.200904105 (DOI: 10.1083/jcb.200904105, PubMed: 19667129)
105.	Sachiko Takeichi, Yoshiaki Kubo, Seiji Arase, Takashi Hashimoto and Shin-ichi Ansai : Brunsting-Perry type localized bullous pemphigoid, possibly induced by furosemide administration and sun exposure., European Journal of Dermatology : EJD, Vol.19, No.5, 500-503, 2009. (Summary) A 56-year-old male visited our hospital complaining of irregular-shaped atrophic erythematous plaques with blood crust, erosion, pigmentation, and depigmentation, localized on his forehead, bilateral cheeks, and ear lobes, for over one year. He has been receiving peritoneal dialysis and furosemide administration due to chronic renal failure for four years. Direct immunofluorescence examination exhibited linear depositions of IgG and C3 in the basement membrane zone. Antibodies against the recombinant NC16a-domain of BP180 were negative by enzyme-linked immunosorbent assays (ELISA), though BP230 ELISA was positive. Immunoblotting using extracts of normal human epidermis demonstrated that the patient's serum reacted with BP180 and BP230. IgG class autoantibodies to recombinant proteins of the C-terminal domain of BP180 were also detected by immunoblotting. This case was diagnosed as localized bullous pemphigoid (LBP). Oral administration of prednisolone 10 mg daily was started and furosemide administration was ceased. The eruptions disappeared thereafter with superficial scars. This is the second reported case of Brunsting-Perry type LBP associated with IgG class autoantibodies to the C-terminal domain of BP180. Furthermore, photosensitivity caused by furosemide administration may contribute to the induction and exacerbation of the lesions. (Keyword) Autoantibodies / Autoantigens / Diuretics / Furosemide / Humans / Male / Middle Aged / Non-Fibrillar Collagens / Pemphigoid, Bullous / Sunlight (Link to Publication Site) ● Publication site (DOI): 10.1684/ejd.2009.0715 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19502152 ● Search Scopus @ Elsevier (PMID): 19502152 ● Search Scopus @ Elsevier (DOI): 10.1684/ejd.2009.0715 (DOI: 10.1684/ejd.2009.0715, PubMed: 19502152)
106.	Yasutoshi Hida, Yoshiaki Kubo, Osamu Miyajima and Seiji Arase : Primary dermal melanoma: A case report and molecular characterization., The Journal of Dermatology, Vol.36, No.6, 346-352, 2009. (Summary) Swetter et al. proposed primary dermal melanoma (PDM) as a distinct entity based on an excellent prognosis. The histopathological features of PDM are extremely similar to those of metastatic melanoma or clear cell sarcoma (CCS). We describe a 38-year-old woman with a subcutaneous tumor in her left thigh. Physical and imaging examinations showed no evidence of metastatic melanoma. The lesion showed obvious strong expression of KIT by immunohistochemistry, but no EWS-ATF1 fusion transcript specific for CCS was detected by reverse transcription polymerase chain reaction. In further analyses of KIT expression in other tumors, three of four primary melanomas (75%) and six of 12 metastatic melanomas (50%) were moderately or strongly positive, however, both the primary and metastatic lesions of CCS tested negative. We believe this to be a case of PDM, and emphasize the distinctiveness of PDM. (Keyword) Adult / DNA Mutational Analysis / Fatal Outcome / Female / Genes, ras / Humans / Melanoma / Oncogene Proteins, Fusion / Proto-Oncogene Proteins B-raf / Proto-Oncogene Proteins c-kit / Skin Neoplasms / Transcription Factors (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1346-8138.2009.00650.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19500183 ● Search Scopus @ Elsevier (PMID): 19500183 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1346-8138.2009.00650.x (DOI: 10.1111/j.1346-8138.2009.00650.x, PubMed: 19500183)
107.	Yoshihiro Matsudate, Yasutoshi Hida, Shin-ichi Ansai, Yoshiaki Kubo and Seiji Arase : 脳梗塞後に左側鼻翼欠損をきたしたTrigeminal Trophic Syndromeの1例, Hifuka No Rinsho, Vol.51, No.3, 351-354, 2009. (Keyword) trigeminal trophic syndrome / 脳梗塞 / 鼻翼欠損 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522543655042518784 (CiNii: 1522543655042518784)
108.	Yoshihiro Matsudate, Shin-ichi Ansai, Kenji Hirose, Yoshiaki Kubo and Seiji Arase : Pemphigoid nodularis : the importance of ELISA for diagnosis, European Journal of Dermatology : EJD, Vol.19, No.1, 83-84, 2009. (Keyword) Aged / Biopsy / Diagnosis, Differential / Enzyme-Linked Immunosorbent Assay / Humans / Infant / Middle Aged / Pemphigoid, Bullous (Link to Publication Site) ● Publication site (DOI): 10.1684/ejd.2008.0557 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19171543 ● Search Scopus @ Elsevier (PMID): 19171543 ● Search Scopus @ Elsevier (DOI): 10.1684/ejd.2008.0557 (DOI: 10.1684/ejd.2008.0557, PubMed: 19171543)
109.	Yasutoshi Hida, Yoshiaki Kubo, Yukiko Nishio, Shinji Murakami, Daisuke Fukumoto, Koji Sayama, Koji Hashimoto and Seiji Arase : Malignant acanthosis nigricans with enhanced expression of fibroblast growth factor receptor 3., Acta Dermato-Venereologica, Vol.89, No.4, 435-437, 2009. (Keyword) Acanthosis Nigricans / Adenocarcinoma / Aged / Cardia / Fatal Outcome / Humans / Hypertrophy / Immunohistochemistry / Male / Receptor, Fibroblast Growth Factor, Type 3 / Signal Transduction / Skin / Stomach Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.2340/00015555-0666 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19688170 ● Search Scopus @ Elsevier (PMID): 19688170 ● Search Scopus @ Elsevier (DOI): 10.2340/00015555-0666 (DOI: 10.2340/00015555-0666, PubMed: 19688170)
110.	Eun Ju Jung, Tomoko Kawai, Hwan Ki Park, Yoshiaki Kubo, Kazuhito Rokutan and Seiji Arase : Identification of ultraviolet B-sensitive genes in human peripheral blood cells., The Journal of Medical Investigation : JMI, Vol.55, No.3-4, 204-210, 2008. (Summary) Ultraviolet B (UVB) is a serious irritant for the skin and increases a risk for skin cancer. To identify UVB-sensitive genes in peripheral blood, 11 healthy male volunteers were exposed to 0.3 J/cm(2) of narrow-band (NB)-UVB, about half of minimal erythema dose (MED) in Japanese, and gene expression in blood was analyzed at 4 h, 24 h, 4 d and 7 d after the irradiation using microarray carrying oligonucleotide probes for 2,000 stress-responsive genes. RNA prepared before the irradiation was used as a reference control. Microarray analysis identified 21 genes as UVB-responsive genes with a peak at 24 h in 6 subjects, and real-time PCR validated the significant down-regulation of 9 (ABCB10, ATF1, ABCD3, TANK, FAS, SLC30A9, CHUK, CASP1, and ABCE1) out of the 21 genes in 11 subjects. Considering sensitive and characteristic features of 9 marker genes, they may be useful indicators for monitoring systemic response to UVB irradiation. (Keyword) Adult / Blood Cells / Dose-Response Relationship, Radiation / Down-Regulation / gene expression / Gene Expression Profiling / Genetic Markers / Humans / male / Oligonucleotide Array Sequence Analysis / Reverse Transcriptase Polymerase Chain Reaction / Skin / Stress, Physiological / Ultraviolet Rays / Young Adult (Tokushima University Institutional Repository) ● Metadata: 110860 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.55.204 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18797132 ● Summary page in Scopus @ Elsevier: 2-s2.0-56749154039 (Tokushima University Institutional Repository: 110860, DOI: 10.2152/jmi.55.204, PubMed: 18797132, Elsevier: Scopus)
111.	Kazuya Matsumoto, Hideki Nakanishi, 山中健生, Ichiro Hashimoto and Yoshiaki Kubo : 血管拡張性肉芽腫に対する硬化療法の工夫, 臨床皮膚科, Vol.58, No.8, 681-683, 2004. (Summary) 9歳，男児左小指指尖部に生じた欠陥拡張性肉芽腫に対してモノエタノールアミンオレイン酸溶液の局所注入が奏功した．この硬化療法は，従来の凍結療法が有用でない場合にも効果的であり，病変部への注入量を0.1ml以下にすることで副作用も起こりにくいと考えられる．血管拡張性肉芽腫に対して有用な保存的治療であると思われた． (Keyword) 血管拡張性肉芽腫 / 硬化治療
112.	Kazuya Matsumoto, Hideki Nakanishi, Yoshiaki Kubo, Masahiko Yokozeki and Keiji Moriyama : Advances in distraction techniques for craniofacial surgery., The Journal of Medical Investigation : JMI, Vol.50, No.3-4, 117-125, 2003. (Summary) Distraction osteogenesis has been applied to the craniofacial skeleton as well as the long bones of the extremities. This technique does not require bone grafting and allows correction of craniofacial deformities with less invasion. Moreover, the distraction procedures can expand the overlying soft tissues simultaneously. We determined the indications of distraction osteogenesis, analyzed the types of devices available, and examined patients treated with distraction for the mandible, midface, and cranium. In all three sites, the devices tended to be the buried type and made of absorbable materials. Administration of some cytokines for shortening the consolidation period may be considered. Among disorders indicated for distraction osteogenesis, there are several syndromic craniosynostoses, which involve mutations in the fibroblast growth factor receptor (FGFR) 2 gene. The FGFR 2 mutation was suggested to clinically accelerate osteogenesis at the distraction site. The usefulness and appropriateness of the distraction protocol must be assessed for each individual disorder. Although distraction osteogenesis in the craniofacial skeleton has advanced technologically, all possible risks must be discussed with the patient and family members when obtaining preoperative informed consent, especially until establishment of fully safe distraction procedures. (Keyword) Adult / Child / Craniofacial Abnormalities / Craniosynostoses / Female / Humans / Infant / Male / Mutation / Osteogenesis, Distraction / Receptor Protein-Tyrosine Kinases / Receptor, Fibroblast Growth Factor, Type 2 / Receptors, Fibroblast Growth Factor / Skull (Tokushima University Institutional Repository) ● Metadata: 110686 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 13678380 ● CiNii @ National Institute of Informatics (CRID): 1050282812442861952 ● Summary page in Scopus @ Elsevier: 2-s2.0-0346880369 (Tokushima University Institutional Repository: 110686, PubMed: 13678380, CiNii: 1050282812442861952, Elsevier: Scopus)
113.	Takuya Seike, Kazuya Matsumoto, Hideki Nakanishi, Ichiro Hashimoto, Yoshiaki Kubo and Seiji Arase : Malignant Melanoma of Soft Parts (Clear Cell Sarcoma), --- A Case Report ---, The Journal of Dermatology, Vol.30, No.7, 550-555, 2003. (Summary) A subcutaneous tumor localized on the sole of the foot of a 25-year-old Japanese man was diagnosed as a malignant melanoma of the soft parts. We performed a wide local excision, elective lymph node dissection, and chemotherapy. Eight years after treatment, the patient is alive without local recurrence or metastasis. (Keyword) Adult / Biopsy, Needle / Chemotherapy, Adjuvant / Combined Modality Therapy / Foot / Humans / Immunohistochemistry / Male / Melanoma / Prognosis / Risk Assessment / Sarcoma, Clear Cell / Skin Neoplasms / Skin Transplantation / Surgical Procedures, Operative / Treatment Outcome (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12928546 ● Search Scopus @ Elsevier (PMID): 12928546 (PubMed: 12928546)
114.	Kazuya Matsumoto, Hideki Nakanishi, Koizumi Yoshio, Seike Takuya, Kanda Ikuno and Yoshiaki Kubo : Sclerotherapy of Hemangioma with late involution, Dermatologic Surgery, Vol.29, No.6, 668-671, 2003. (Summary) Most cutaneous hemangiomas involute spontaneously. However, the lesion existing on the face poses a cosmetic problem during the waiting period for involution. Hemangioma showing late involution was treated by local injection of monoethanolamine oleate solution. The lesion flattened and was excised serially. Sclerotherapy with monoethanolamine oleate can shorten the waiting period for involution and can decrease the risk of psychosocial trauma. Moreover, it provides good preparation for further surgery. Such sclerotherapy is effective in the treatment of hemangioma with late involution. (Keyword) Dermatologic Agents / Female / Hemangioma / Humans / Infant / Injections, Intralesional / Oleic Acid / Oleic Acids / Sclerotherapy / Skin Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1046/j.1524-4725.2003.29159.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12786717 ● Search Scopus @ Elsevier (PMID): 12786717 ● Search Scopus @ Elsevier (DOI): 10.1046/j.1524-4725.2003.29159.x (DOI: 10.1046/j.1524-4725.2003.29159.x, PubMed: 12786717)
115.	Mirella Lazarov, Cheryl L Green, Jennifer Y Zhang, Yoshiaki Kubo, Maya Dajee and Paul A. Khavari : Escaping G₁ Restraints on Neoplasia: Cdk4 Regulation by Ras and NF-κB., Cell Cycle, Vol.2, No.2, 79-80, 2003. (Keyword) Cell Differentiation / Cell Division / Cyclin-Dependent Kinase 4 / Cyclin-Dependent Kinases / G1 Phase / Gene Expression Regulation, Neoplastic / Humans / Models, Biological / NF-kappa B / Neoplasms / Oncogene Protein p21(ras) / Proto-Oncogene Proteins (Link to Publication Site) ● Publication site (DOI): 10.4161/cc.2.2.339 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12695650 ● Summary page in Scopus @ Elsevier: 2-s2.0-2142805256 (DOI: 10.4161/cc.2.2.339, PubMed: 12695650, Elsevier: Scopus)
116.	Maya Dajee, Mirella Lazarov, Jennifer Y Zhang, Ti Cai, Cheryl L Green, Alan J. Russell, Peter M. Marinkovich, Shiying Tao, Qun Lin, Yoshiaki Kubo and Paul A. Khavari : NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia., Nature, Vol.421, No.6923, 639-643, 2003. (Summary) The nuclear factor NF-kappaB and oncogenic Ras can alter proliferation in epidermis, the most common site of human cancer. These proteins are implicated in epidermal squamous cell carcinoma in mice, however, the potential effects of altering their function are uncertain. Whereas inhibition of NF-kappaB enhances apoptosis in certain tumours, blockade of NF-kappaB predisposes murine skin to squamous cell carcinoma. Because therapeutics inhibiting Ras and NF-kappaB pathways are being developed to treat human cancer, it is essential to assess the effects of altering these regulators. The medical relevance of murine studies is limited, however, by differences between mouse and human skin, and by the greater ease of transforming murine cells. Here we show that in normal human epidermal cells both NF-kappaB and oncogenic Ras trigger cell-cycle arrest. Growth arrest triggered by oncogenic Ras can be bypassed by IkappaBalpha-mediated blockade of NF-kappaB, generating malignant human epidermal tissue resembling squamous cell carcinoma. Human cell tumorigenesis is dependent on laminin 5 and alpha6beta4 integrin. Thus, IkappaBalpha circumvents restraints on growth promotion induced by oncogenic Ras and can act with Ras to induce invasive human tissue neoplasia. (Keyword) Animals / Apoptosis / Cell Adhesion Molecules / Cell Division / Cyclin-Dependent Kinases / Epidermis / Genes, ras / Humans / I-kappa B Proteins / Integrin alpha6beta4 / Keratinocytes / Mice / Mice, Nude / Mice, SCID / NF-kappa B / Neoplasm Invasiveness / Neoplasms / Oncogene Protein p21(ras) / Telomere / Transduction, Genetic (Link to Publication Site) ● Publication site (DOI): 10.1038/nature01283 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12571598 ● Search Scopus @ Elsevier (PMID): 12571598 ● Search Scopus @ Elsevier (DOI): 10.1038/nature01283 (DOI: 10.1038/nature01283, PubMed: 12571598)
117.	Mirella Lazarov, Yoshiaki Kubo, Ti Cai, Maya Dajee, Masahito Tarutani, Qun Lin, Min Fang, Shiying Tao, Cheryl L Green and Paul A. Khavari : CDK4 coexpresssion with Ras generates malignant human epidermal tumorigenesis., Nature Medicine, Vol.8, No.10, 1105-1114, 2002. (Summary) Ras acts with other proteins to induce neoplasia. By itself, however, strong Ras signaling can suppress proliferation of normal cells. In primary epidermal cells, we found that oncogenic Ras transiently decreases cyclin-dependent kinase (CDK) 4 expression in association with cell cycle arrest in G1 phase. CDK4 co-expression circumvents Ras growth suppression and induces invasive human neoplasia resembling squamous cell carcinoma. Tumorigenesis is dependent on CDK4 kinase function, with cyclin D1 required but not sufficient for this process. In facilitating escape from G1 growth restraints, Ras and CDK4 alter the composition of cyclin D and cyclin E complexes and promote resistance to growth inhibition by INK4 cyclin-dependent kinase inhibitors. These data identify a new role for oncogenic Ras in CDK4 regulation and highlight the functional importance of CDK4 suppression in preventing uncontrolled growth. (Keyword) Animals / Cadherins / Carcinoma, Squamous Cell / Cell Cycle / Cells, Cultured / Cyclin D1 / Cyclin E / Cyclin-Dependent Kinase 4 / Cyclin-Dependent Kinases / Endothelial Growth Factors / Epidermis / Gene Transfer Techniques / Genes, Reporter / Humans / Intercellular Signaling Peptides and Proteins / Keratinocytes / Lung / Lymphokines / Mice / Mitogen-Activated Protein Kinases / Proto-Oncogene Proteins / Recombinant Fusion Proteins / Skin Neoplasms / Telomere / Vascular Endothelial Growth Factor A / Vascular Endothelial Growth Factors / ras Proteins (Link to Publication Site) ● Publication site (DOI): 10.1038/nm779 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12357246 ● Search Scopus @ Elsevier (PMID): 12357246 ● Search Scopus @ Elsevier (DOI): 10.1038/nm779 (DOI: 10.1038/nm779, PubMed: 12357246)
118.	Yoshiaki Kubo, Kazutoshi Murao, Kazuya Matsumoto and Seiji Arase : Molecular carcinogenesis of squamous cell carcinomas of the skin., The Journal of Medical Investigation : JMI, Vol.49, No.3-4, 111-117, 2002. (Summary) Squamous cell carcinomas (SCCs) of the skin were suggested to develop through a multistep process that involves activation of proto-oncogenes and/or inactivation of tumor suppressor genes in the human skin keratinocytes. Exposure to ultra-violet (UV), especially UV-B, radiation is the most common cause for these genetic abnormalities in cells. We review causation of SCCs and genetic abnormalities in human SCCs with the current work. To elucidate the multistep process, we developed a method for examining the combinatorial function in vivo of plural genes in human keratinocytes. Using high efficiency retroviral transductions, we could express plural genes serially in normal human primary keratinocytes and use these cells to regenerate human skin on SCID mice. A combinatorial transduction of H-RasV12 and cyclin dependent kinase 4 (CDK4) produced human epidermal neoplasia resembling SCC. These findings were consistent with our previous results of mutation analysis in SCCs, one of which had both mutations of H-Ras gene and the INK4a locus. Therefore, it is suggested that a combination of these genetic abnormalities might be crucial to the carcinogenesis at least in a subset of SCCs. (Keyword) Animals / Carcinoma, Squamous Cell / Cell Cycle Proteins / Cell Transformation, Neoplastic / DNA Damage / DNA Repair / Gene Expression Regulation, Neoplastic / Genes, p16 / Genes, p53 / Genes, ras / Humans / Keratinocytes / Loss of Heterozygosity / Mice / Mice, SCID / Neoplasms, Radiation-Induced / Skin Neoplasms / Ultraviolet Rays (Tokushima University Institutional Repository) ● Metadata: 110643 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12322999 ● Search Scopus @ Elsevier (PMID): 12322999 (Tokushima University Institutional Repository: 110643, PubMed: 12322999)
119.	Yasutoshi Hida, 浦野芳夫, Yoshiaki Kubo, 南満芳, 村尾牧子, 津田英隆, Kazutoshi Murao, 高野浩章, Seiji Arase and 長江浩朗 : 足底に難治性潰瘍を伴ったWerner症候群の3例, 臨床皮膚科, Vol.56, No.7, 487-491, 2002. (Keyword) Werner症候群 / WRN遺伝子 / 足底潰瘍
120.	Kazuya Matsumoto, Hideki Nakanishi, Takuya Seike, Yoshio Koizumi, Keiichi Mihara and Yoshiaki Kubo : Treatment of Pyogenic Granuloma with a Sclerosing Agent, Dermatologic Surgery, Vol.27, No.6, 521-523, 2001. (Link to Publication Site) ● Publication site (DOI): 10.1046/j.1524-4725.2001.01039.x (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0034968750 (DOI: 10.1046/j.1524-4725.2001.01039.x, Elsevier: Scopus)
121.	Yoshiaki Kubo, Yoshio Urano, Yasutoshi Hida, Tsuneo Ikeuchi, Masashi Nomoto, Kazufumi Kunitomo and Seiji Arase : A novel PTEN mutation in a Japanese patient with Cowden disease., The British Journal of Dermatology, Vol.142, No.6, 1100-1105, 2000. (Summary) Cowden disease (CD) is an autosomal dominant syndrome characterized by multiple hamartomatous lesions and an increased risk for malignancies. Recent evidence has indicated that the PTEN gene, encoding a protein tyrosine phosphatase, is the CD susceptibility gene. However, another line of evidence has suggested that CD might be genetically heterogeneous. Clinical features of CD are variable, and there are interfamilial differences in the expression of skin lesions. Therefore, information on PTEN mutations in CD patients should be accumulated to clarify the genotype-phenotype correlation. In the present study, we found heterozygous germline mutations of PTEN in all of three Japanese patients with CD examined, indicating no genetic heterogeneity among our patients. The mutations included two non-sense mutations of R335X and R130X, and a mis-sense mutation of C136R. To the best of our knowledge, the C136R mutation has not previously been reported in CD patients. This novel mutation was located outside the core motif of the phosphatase domain of PTEN protein, where most of the missense mutations previously reported in CD patients were clustered. Mucocutaneous manifestations were far fewer in the patient with this mutation than in the patients with nonsense mutations. Whether the phenotypic difference in mucocutaneous features was due to the different mutations remains unclear. (Keyword) Adult / DNA Mutational Analysis / Female / Germ-Line Mutation / Hamartoma Syndrome, Multiple / Humans / Japan / Middle Aged / PTEN Phosphohydrolase / Phosphoric Monoester Hydrolases / Polymerase Chain Reaction / Polymorphism, Single-Stranded Conformational / Tumor Suppressor Proteins (Link to Publication Site) ● Publication site (DOI): 10.1046/j.1365-2133.2000.03533.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10848731 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034100074 (DOI: 10.1046/j.1365-2133.2000.03533.x, PubMed: 10848731, Elsevier: Scopus)
122.	Yoshiaki Kubo, Yoshio Urano, Yasutoshi Hida and Seiji Arase : Lack of somatic mutation in the PTEN gene in squamous cell carcinomas of human skin., Journal of Dermatological Science, Vol.19, No.3, 199-201, 1999. (Summary) The tumor suppressor gene PTEN is deleted and/or mutated in a variety of tumors and the susceptibility gene for Cowden disease. Loss of heterozygosity of chromosome 10q23, where PTEN resides, in squamous cell carcinomas (SCCs) of human skin and the association of SCC with Cowden disease were reported previously. In the present study, we screened for mutations of PTEN in SCCs by polymerase chain reaction single strand conformation polymorphism analysis to examine whether PTEN is involved in the carcinogenesis of SCC. None of 21 SCCs showed somatic mutations in the coding regions of PTEM. Instead the same allelic variation was detected in two cases without any clinical features of Cowden disease. Our results indicate that inactivation of PTEN does not play an important role in the carcinogenesis of SCC. (Keyword) Carcinoma, Squamous Cell / DNA, Neoplasm / Humans / Mutation / PTEN Phosphohydrolase / Phosphoric Monoester Hydrolases / Polymorphism, Single-Stranded Conformational / Skin Neoplasms / Tumor Suppressor Proteins (Link to Publication Site) ● Publication site (DOI): 10.1016/S0923-1811(98)00058-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10215192 ● Search Scopus @ Elsevier (PMID): 10215192 ● Search Scopus @ Elsevier (DOI): 10.1016/S0923-1811(98)00058-9 (DOI: 10.1016/S0923-1811(98)00058-9, PubMed: 10215192)
123.	Kazuya Matsumoto, Hideki Nakanishi, Yoshio Urano, Yoshiaki Kubo and Hiroaki Nagae : Lower eyelid reconstruction with a cheek flap supported by fascia lata., Plastic and Reconstructive Surgery, Vol.103, No.6, 1650-1654, 1999.
124.	Yoshiaki Kubo, Yoshio Urano, Kosaku Fukuhara, Kazuya Matsumoto and Seiji Arase : Lack of mutation in the INK4a locus in basal cell carcinomas., The British Journal of Dermatology, Vol.139, No.2, 340-341, 1998. (Keyword) Carcinoma, Basal Cell / Cyclin-Dependent Kinase Inhibitor p16 / Genes, Tumor Suppressor / Humans / Male / Middle Aged / Mutation / Neoplasm Proteins / Skin Neoplasms (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9767257 ● Search Scopus @ Elsevier (PMID): 9767257 (PubMed: 9767257)
125.	Kazuya Matsumoto, 浦野芳夫, Yoshiaki Kubo, 平林慎一, 桜井淳 and Hideki Nakanishi : 東洋人のApert症候群患者におけるFibroblastgrowth factor receptor 2遺伝子の変異―2症例の検討―, 日本形成外科学会雑誌, Vol.18, No.11, 583-586, 1998.
126.	Kazuya Matsumoto, 浦野芳夫, Hideki Nakanishi, Hajimu Oura, 榊哲彦, Yoshiaki Kubo, 洙田由美子, 田中伸二 and Seiji Arase : 血清CEAが高値を示したeccrine porocarcinomaの1例, Skin Cancer, Vol.13, No.1, 27-31, 1998.
127.	Kazuya Matsumoto, Yoshio Urano, Yoshiaki Kubo, Hideki Nakanishi and Seiji Arase : Mutation of the fibrobrast growth factor receptor2 gene in Japanese patients with Apert syndrome, Plastic and Reconstructive Surgery, Vol.101, No.2, 307-311, 1998.
128.	Yoshiaki Kubo, Yoshio Urano, Kazuya Matsumoto, Kamrul Ahsan and Seiji Arase : Mutations of the INK4a locus in squamous cell carcinomas of human skin., Biochemical and Biophysical Research Communications, Vol.232, 38-42, 1997.
129.	Kazuya Matsumoto, 浦野芳夫, 榊哲彦, 宮本洋, 田中伸二, Yoshiaki Kubo, 福原耕作, Seiji Arase and Hideki Nakanishi : 単純性血管腫上に生じた基底細胞癌, Japanese Journal of Plastic Surgery, Vol.40, No.9, 873-878, 1997.
130.	Yoshio Urano, Takashi Asano, Katsuhiko Yoshimoto, Hiroyuki Iwahana, Yoshiaki Kubo, Shoji Kato, Shiro Sasaki, Norifumi Takeuchi, Naoyuki Uchida, Hideki Nakanishi, Seiji Arase and Mitsuo Itakura : Frequent p53 Accumulation in the Chronically Sun-Exposed Epidermis and Clonal Expansion of p53 Mutant Cells in the Epidermis Adjacent to Basal Cell Carcinoma., The Journal of Investigative Dermatology, Vol.104, No.6, 928-932, 1995.
131.	Toshiyuki Kobayashi, Youko Hirayama, Etsuko Kobayashi, Yoshiaki Kubo and Okio Hino : A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer., Nature Genetics, Vol.9, No.1, 70-74, 1995. (Summary) The Eker rat hereditary renal carcinoma (RC) is an excellent example of a mendelian dominant predisposition to a specific cancer in an experimental animal. We have previously established a new conserved linkage group on rat chromosome 10q and human chromosome 16p13.3, and shown that the Eker mutation is tightly linked to the tuberous sclerosis (Tsc2) gene. We now describe a germline mutation in the gene encoding Tsc2 caused by the insertion of an approximately 5 kilobase DNA fragment in the Eker rat, resulting in aberrant RNA expression from the mutant allele. The phenotype of tuberous sclerosis in humans differs from that of the Eker rat, except for the occurrence of renal tumours. The Eker rat may therefore provide insights into species-specific differences in tumourigenesis and/or phenotype-specific mutations. (Keyword) Amino Acid Sequence / Animals / Base Sequence / Carcinoma, Renal Cell / DNA / DNA Primers / Disease Models, Animal / Female / Gene Expression / Germ-Line Mutation / Heterozygote / Homozygote / Humans / Kidney Neoplasms / Male / Molecular Sequence Data / Rats / Tuberous Sclerosis (Link to Publication Site) ● Publication site (DOI): 10.1038/ng0195-70 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7704028 ● Search Scopus @ Elsevier (PMID): 7704028 ● Search Scopus @ Elsevier (DOI): 10.1038/ng0195-70 (DOI: 10.1038/ng0195-70, PubMed: 7704028)
132.	Yoshiaki Kubo, Yasushi Kikuchi, Hiroaki Mitani, Etsuko Kobayashi, Toshiyuki Kobayashi and Okio Hino : Allelic loss at the Tuberous Sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model., Japanese Journal of Cancer Research, Vol.82, 828-832, 1995.
133.	Yoshiaki Kubo, Fritz Klimek, Yasushi Kikuchi, Peter Bannasch and Okio Hino : Early detection of Knudson's two-hit in preneoplastic renal cells of the Eker rat model by the laser microdissection procedure., Cancer Research, Vol.55, 989-990, 1995.
134.	Yoshiaki Kubo, Yoshio Urano, Katsuhiko Yoshimoto, Hiroyuki Iwahana, Kosaku Fukuhara, Seiji Arase and Mitsuo Itakura : p53 Gene Mutations in Human Skin Cancers and Precancerous Lesions: Comparison with Immunohistochemical Analysis., The Journal of Investigative Dermatology, Vol.102, No.4, 440-444, 1994.
135.	Yoshiaki Kubo, Hiroaki Mitani and Okio Hino : Allelic loss at the predisposing gene locus in spontaneous and chemically induced renal cell carcinomas in the Eker rat., Cancer Research, Vol.54, 2633-2635, 1994.

Academic Paper (Unrefereed Paper):

1.	Tetsuya Hida, Mitsuyoshi Minami and Yoshiaki Kubo : Bilateral leg ulcers secondary to dystrophic calcinosis in a patient with rheumatoid arthritis., The Journal of Medical Investigation : JMI, Vol.64, No.4, 308-310, 2017. (Summary) Calcinosis cutis can be classified into four subtypes: dystrophic, metastatic, idiopathic, and iatrogenic. Of these subtypes, dystrophic calcinosis (DC) is the most common, and is most frequently associated with connective tissue disease, particularly dermatomyositis and systemic sclerosis, and less commonly with systemic lupus erythematosus. However, DC associated with rheumatoid arthritis (RA) is extremely rare. In this paper, we present a Japanese woman with RA, who suffered from bilateral leg ulcers secondary to DC. To the best of our knowledge, only two cases of DC associated with RA have been reported to date. Similar to this case, the DC lesions were observed in the extremities, including the buttocks in the other two cases. Although the ulcers on her left leg were gradually epithelialized after one year, they may easily recur due to whitish abnormal underlying tissues, and a large ulcer remains on her right leg. Thus, it is important for physicians to identify DC when encountering non-healing leg ulcers associated with connective tissue diseases. J. Med. Invest. 64: 308-310, August, 2017. (Keyword) Aged / Arthritis, Rheumatoid / Calcinosis / Female / Humans / Leg Ulcer (Tokushima University Institutional Repository) ● Metadata: 111140 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.64.308 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28955003 ● Summary page in Scopus @ Elsevier: 2-s2.0-85030235273 (Tokushima University Institutional Repository: 111140, DOI: 10.2152/jmi.64.308, PubMed: 28955003, Elsevier: Scopus)
2.	Yoshihiro Matsudate, Issei Imoto and Yoshiaki Kubo : 後天性リンパ管腫を契機に診断に至ったCowden病の1家系, Practical Dermatology, Vol.38, No.8, 777-780, 2016. (Link to Publication Site) ● Publication site (DOI): 10.24733/J01268.2016356556 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.24733/J01268.2016356556 (DOI: 10.24733/J01268.2016356556)
3.	大津雅信, Kenji Hirose, Yoshiaki Kubo, Seiji Arase and 門田耕作 : blue rubber bleb nevus syndrome, Visual Dermatology, Vol.10, No.7, 726-727, 2011.
4.	Yoshiaki Kubo, Takeshi Ishigami and Kazutoshi Murao : リップクリーム中のミツロウによる接触皮膚炎, 皮膚病診療, Vol.33, No.7, 703-706, 2011.
5.	Takeshi Ishigami and Yoshiaki Kubo : 下口唇に有棘細胞癌を生じた色素性乾皮症バリアント, Visual Dermatology, Vol.10, No.5, 482-483, 2011.

Academic Letter:

1.	Kazutoshi Murao and Yoshiaki Kubo : Multiple Bowen disease lesions with the eyeliner sign in a psoriasis patient after long-term narrow-band ultraviolet B light therapy., The American Journal of Dermatopathology, Vol.46, No.3, 193-194, 2024. (Keyword) Humans / Bowen's Disease / Psoriasis / Skin Neoplasms / Treatment Outcome / Ultraviolet Therapy (Link to Publication Site) ● Publication site (DOI): 10.1097/DAD.0000000000002634 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38275222 ● Summary page in Scopus @ Elsevier: 2-s2.0-85185221624 (DOI: 10.1097/DAD.0000000000002634, PubMed: 38275222, Elsevier: Scopus)
2.	Kazutoshi Murao and Yoshiaki Kubo : A case of childhood granulomatous periorificial dermatitis mimicking lichen nitidus, International Journal of Dermatology, Vol.62, No.3, e133-e135, 2023. (Keyword) Humans / Lichen Nitidus / Dermatitis, Perioral / Eczema / Exanthema / Pruritus (Link to Publication Site) ● Publication site (DOI): 10.1111/ijd.16270 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35569093 ● Summary page in Scopus @ Elsevier: 2-s2.0-85132614935 (DOI: 10.1111/ijd.16270, PubMed: 35569093, Elsevier: Scopus)
3.	Kazutoshi Murao, Maiko Sogawa and Yoshiaki Kubo : A case of an insect bite-like reaction in a patient with angioimmunoblastic T-cell lymphoma., European Journal of Dermatology : EJD, Vol.29, No.4, 425-426, 2019. (Keyword) Aged / Female / Humans / Immunoblastic Lymphadenopathy / Insect Bites and Stings / Lymphoma, T-Cell, Cutaneous / Skin Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1684/ejd.2019.3571 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31456577 ● Search Scopus @ Elsevier (PMID): 31456577 ● Search Scopus @ Elsevier (DOI): 10.1684/ejd.2019.3571 (DOI: 10.1684/ejd.2019.3571, PubMed: 31456577)
4.	Yoshihiro Matsudate, Mariko Niki, Yasutoshi Hida and Yoshiaki Kubo : Coexistence of X-linked ichthyosis and Nagashima-type palmoplantar keratosis: A case report., The Journal of Dermatology, Vol.46, No.2, e54-e55, 2019. (Link to Publication Site) ● Publication site (DOI): 10.1111/1346-8138.14537 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30004585 ● Search Scopus @ Elsevier (PMID): 30004585 ● Search Scopus @ Elsevier (DOI): 10.1111/1346-8138.14537 (DOI: 10.1111/1346-8138.14537, PubMed: 30004585)
5.	Nozomi Fukui, Kazutoshi Murao, Maiko Sogawa and Yoshiaki Kubo : Case of papular acantholytic dyskeratosis of the genital area successfully treated with topical vitamin D3 ointment, The Journal of Dermatology, Vol.44, No.5, 599-560, 2017. (Link to Publication Site) ● Publication site (DOI): 10.1111/1346-8138.13488 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27334529 ● Search Scopus @ Elsevier (PMID): 27334529 ● Search Scopus @ Elsevier (DOI): 10.1111/1346-8138.13488 (DOI: 10.1111/1346-8138.13488, PubMed: 27334529)
6.	Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : Chemotherapy-induced inflammation of seborrheic keratoses due to pemetrexed treatment, The Journal of Dermatology, Vol.44, No.5, 602-603, 2017. (Link to Publication Site) ● Publication site (DOI): 10.1111/1346-8138.13499 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27345694 ● Search Scopus @ Elsevier (PMID): 27345694 ● Search Scopus @ Elsevier (DOI): 10.1111/1346-8138.13499 (DOI: 10.1111/1346-8138.13499, PubMed: 27345694)
7.	Kazutoshi Murao, Ayaka Nakasuka, Tsuyoshi Keyama, Ichiro Hashimoto and Yoshiaki Kubo : Case of multiple Bowen diseases associated with human papillomavirus type 16 in a patient with atopic dermatitis., The Journal of Dermatology, Vol.43, No.4, 445-447, 2016. (Keyword) Administration, Cutaneous / Bowen's Disease / Dermatitis, Atopic / Glucocorticoids / Human papillomavirus 16 / Humans / Male / Middle Aged / Neck / Ointments / Papillomavirus Infections / Polymerase Chain Reaction / Skin Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1111/1346-8138.13216 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26662565 ● Summary page in Scopus @ Elsevier: 2-s2.0-84949883866 (DOI: 10.1111/1346-8138.13216, PubMed: 26662565, Elsevier: Scopus)
8.	Yoshihiro Matsudate, Mayu Yuasa, Nozomi Fukui, Kenji Hirose, Kazutoshi Murao and Yoshiaki Kubo : Case of nevoid basal cell carcinoma syndrome with multiple cutaneous keratocysts., The Journal of Dermatology, Vol.42, No.10, 1015-1016, 2015. (Link to Publication Site) ● Publication site (DOI): 10.1111/1346-8138.13022 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26126618 ● Search Scopus @ Elsevier (PMID): 26126618 ● Search Scopus @ Elsevier (DOI): 10.1111/1346-8138.13022 (DOI: 10.1111/1346-8138.13022, PubMed: 26126618)
9.	Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : Primary cutaneous mucormycosis caused by Mucor irregularis in an immunocompetent patient, The Journal of Dermatology, Vol.42, No.3, 267-268, 2015. (Link to Publication Site) ● Publication site (DOI): 10.1111/1346-8138.12788 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25736319 ● Summary page in Scopus @ Elsevier: 2-s2.0-84924033151 (DOI: 10.1111/1346-8138.12788, PubMed: 25736319, Elsevier: Scopus)
10.	Kazutoshi Murao, Yoshiaki Kubo and Seiji Arase : Woolly hair nevus: neonatal alopecia can be an initial manifestation., International Journal of Dermatology, Vol.52, No.12, 1588-1589, 2013. (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1365-4632.2011.05420.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24261737 ● Search Scopus @ Elsevier (PMID): 24261737 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1365-4632.2011.05420.x (DOI: 10.1111/j.1365-4632.2011.05420.x, PubMed: 24261737)
11.	Kazutoshi Murao, Mayumi Minato and Yoshiaki Kubo : Improvement of palmoplantar pustulosis lesions after angioplasty for Leriche syndrome., The Australasian Journal of Dermatology, Vol.54, No.3, e80-81, 2013. (Summary) Although a wide range of treatments have been used in the treatment of palmoplantar pustulosis (PPP), PPP is still very difficult to treat. We report a patient who had a dramatic reduction in PPP lesions after bypass surgery for Leriche syndrome. We assume that improved blood circulation had a crucial impact in reducing PPP lesions and suggest improving blood circulation could be another treatment option. (Keyword) Angioplasty / Aorta, Abdominal / Diabetes Mellitus / Female / Foot Dermatoses / Humans / Iliac Artery / Leriche Syndrome / Lower Extremity / Middle Aged / Psoriasis / Severity of Illness Index / Vascular Grafting (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1440-0960.2012.00940.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22943836 ● Search Scopus @ Elsevier (PMID): 22943836 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1440-0960.2012.00940.x (DOI: 10.1111/j.1440-0960.2012.00940.x, PubMed: 22943836)
12.	Kazutoshi Murao and Yoshiaki Kubo : A case of lichen planus significantly improved after topical heparinoid treatment, The Australasian Journal of Dermatology, Vol.54, No.3, 236-237, 2013. (Keyword) Administration, Cutaneous / Aged, 80 and over / Anti-Inflammatory Agents / Female / Heparinoids / Humans / Lichen Planus (Link to Publication Site) ● Publication site (DOI): 10.1111/ajd.12080 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23905977 ● Search Scopus @ Elsevier (PMID): 23905977 ● Search Scopus @ Elsevier (DOI): 10.1111/ajd.12080 (DOI: 10.1111/ajd.12080, PubMed: 23905977)
13.	Kazutoshi Murao and Yoshiaki Kubo : Multiple epidermal cysts in hemodialysis patients, European Journal of Dermatology : EJD, Vol.22, No.2, 264-265, 2012. (Keyword) Adult / Cysts / Humans / Kidney Failure, Chronic / Male / Middle Aged / Renal Dialysis / Skin Diseases (Link to Publication Site) ● Publication site (DOI): 10.1684/ejd.2011.1626 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22240490 ● Search Scopus @ Elsevier (PMID): 22240490 ● Search Scopus @ Elsevier (DOI): 10.1684/ejd.2011.1626 (DOI: 10.1684/ejd.2011.1626, PubMed: 22240490)
14.	Kazutoshi Murao, Mika Oshima, Osamu Miyajima and Yoshiaki Kubo : Verrucous skin lesions on the feet in diabetic neuropathy successfully treated with topical maxacalcitol, European Journal of Dermatology : EJD, Vol.22, No.2, 274-275, 2012. (Keyword) Adult / Calcitriol / Dermatologic Agents / Diabetes Mellitus, Type 2 / Diabetic Foot / Diabetic Neuropathies / Foot Dermatoses / Friction / Humans / Male / Pressure (Link to Publication Site) ● Publication site (DOI): 10.1684/ejd.2012.1640 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22236391 ● Search Scopus @ Elsevier (PMID): 22236391 ● Search Scopus @ Elsevier (DOI): 10.1684/ejd.2012.1640 (DOI: 10.1684/ejd.2012.1640, PubMed: 22236391)
15.	Kazutoshi Murao, Yoshiaki Kubo and Seiji Arase : Verrucous extramammary Pagets disease accompanying human papillomavirus 40-associated condyloma acuminatum: importance of multiple skin biopsies, European Journal of Dermatology : EJD, Vol.21, No.2, 297-298, 2011. (Keyword) Aged / Biopsy / Carcinoma, Verrucous / Condylomata Acuminata / Genital Neoplasms, Male / Humans / Immunohistochemistry / Male / Paget Disease, Extramammary / Papillomavirus Infections / Skin (Link to Publication Site) ● Publication site (DOI): 10.1684/ejd.2011.1260 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21398204 ● Search Scopus @ Elsevier (PMID): 21398204 ● Search Scopus @ Elsevier (DOI): 10.1684/ejd.2011.1260 (DOI: 10.1684/ejd.2011.1260, PubMed: 21398204)
16.	Kazutoshi Murao, Hiromi Takeichi, Yoshiaki Kubo and Seiji Arase : Multiple pilosebaceous cysts induced by topical steroid therapy, European Journal of Dermatology : EJD, Vol.20, No.6, 815-816, 2010. (Keyword) Administration, Topical / Adrenal Cortex Hormones / Aged / Cysts / Humans / Male / Sebaceous Glands / Skin Diseases (Link to Publication Site) ● Publication site (DOI): 10.1684/ejd.2010.1056 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20822973 ● Search Scopus @ Elsevier (PMID): 20822973 ● Search Scopus @ Elsevier (DOI): 10.1684/ejd.2010.1056 (DOI: 10.1684/ejd.2010.1056, PubMed: 20822973)
17.	Kazutoshi Murao, Yoshiaki Kubo, Takeshi Ishigami and Seiji Arase : Lack of association between extramammary Pagets disease and human papillomavirus infection, Journal of Dermatological Science, Vol.59, No.3, 209-210, 2010. (Keyword) Aged / Aged, 80 and over / Female / Humans / Male / Paget Disease, Extramammary / Papillomavirus Infections / Skin Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jdermsci.2010.07.002 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20685084 ● Search Scopus @ Elsevier (PMID): 20685084 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jdermsci.2010.07.002 (DOI: 10.1016/j.jdermsci.2010.07.002, PubMed: 20685084)

Review, Commentary:

1.	Yoshiaki Kubo : 有棘細胞がん, Dermatology, Vol.2, No.6, 762-768, Dec. 2022.
2.	Tetsuji Takayama, 五十嵐正広, 大住省三, 岡志郎, 角田文彦, Yoshiaki Kubo, 熊谷秀規, 佐々木美香, 菅井有, 菅野康吉, 武田祐子, 土山寿志, 阪埜浩司, 深堀優, 古川洋一, 堀松高博, Naoki Muguruma, 石川秀樹, 岩間毅夫, 岡崎康司, 斎藤豊, 武藤倫弘, 冨田尚弘, 秋山卓士, 山本敏樹, 石田秀行 and 中山圭子 : 小児・成人のためのCowden症候群/PTEN過誤腫症候群診療ガイドライン(2020年版), Journal of Hereditary Tumors, Vol.20, No.2, 93-114, Sep. 2020. (Link to Publication Site) ● Publication site (DOI): 10.18976/jsht.20.2_93 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.18976/jsht.20.2_93 (DOI: 10.18976/jsht.20.2_93)
3.	Yoshiaki Kubo : 皮膚癌, 今日の治療指針 2019年版, 1287-1288, Jan. 2019.
4.	大津雅信 and Yoshiaki Kubo : これが皮膚科診療スペシャリストの目線!診断・検査マニュアル―不変の知識と最新の情報― ツツガムシ病, MB Derma, Vol.268, No.4, 255-259, Apr. 2018.
5.	Yoshiaki Kubo : 乳幼児健診―診察のポイント&保護者の疑問・相談にこたえる保護者の疑問・相談にこたえるために母斑(あざ), Pediatrics of Japan, Vol.58, No.9, 1014-1018, Aug. 2017.
6.	Yoshiaki Kubo : 皮膚発癌の分子機構―最近の知見―, Japanese Journal of Cancer and Chemotherapy, Vol.44, No.4, 299-301, Apr. 2017.
7.	Yoshiaki Kubo : ツツガムシ病，日本紅斑熱，SFTS, Monthly Book Derma, Vol.249, No.10, 49-54, Oct. 2016.
8.	Yoshiaki Kubo : 母斑:青色母斑，色素性母斑，カフェ・オ・レ斑，白斑―蒙古斑も含めて, Japanese Journal of Pediatric Medicine, Vol.48, No.4, 571-575, Apr. 2016.
9.	Yoshiaki Kubo and Yoshihiro Matsudate : Cowden disease (PTEN hamartoma tumor syndrome, Bannayan-Riley-Ruvalcaba syndrome, Multiple hamartoma syndrome)(カウデン病), Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.73, No.6, 85-88, Aug. 2015.
10.	Yoshiaki Kubo : Tumorigenesis of the Epidermal Keratinocytes(the last part)Cancer, The Nishinihon Journal of Dermatology, Vol.77, No.3, 250-255, Jun. 2015. (Keyword) Dermatology (Link to Publication Site) ● Publication site (DOI): 10.2336/nishinihonhifu.77.250 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204300860416 ● Summary page in Scopus @ Elsevier: 2-s2.0-84944326539 (DOI: 10.2336/nishinihonhifu.77.250, CiNii: 1390001204300860416, Elsevier: Scopus)
11.	Yoshiaki Kubo : Tumorigenesis of the Epidermal Keratinocytes(the first part)Introduction, The Nishinihon Journal of Dermatology, Vol.77, No.1, 66-70, Feb. 2015. (Keyword) Dermatology (Link to Publication Site) ● Publication site (DOI): 10.2336/nishinihonhifu.77.66 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204302375680 ● Summary page in Scopus @ Elsevier: 2-s2.0-84937107401 (DOI: 10.2336/nishinihonhifu.77.66, CiNii: 1390001204302375680, Elsevier: Scopus)
12.	Yoshiaki Kubo : 皮膚癌, 今日の治療指針 2015年版, 1077-1078, Jan. 2015.
13.	Yoshiaki Kubo : ライム病, 皮膚疾患最新の治療 2015-2016, 200, Jan. 2015.
14.	Yoshiaki Kubo : 高発癌性遺伝性疾患の概要と最近の知見, The Japanese Journal of Dermatology, Vol.125, No.12, 2277-2282, 2015. (Summary) 高発癌性遺伝性疾患の中で，母斑性基底細胞癌症候群は若年の多発性基底細胞癌の発症と先天奇形を特徴とするが，欧米と比べて本邦では，基底細胞癌の発症率が低く発症年齢が高いことが明らかになってきた．Cowden病は，内臓悪性腫瘍を好発する一方で，特徴的な皮膚粘膜病変を有し，診断における皮膚科医の役割が大きい．遺伝子変異型が表現型と必ずしも一致しないまれな家系もあり，皮膚科医としてそれらの特徴と問題点をおさえておく必要がある． (Link to Publication Site) ● Publication site (DOI): 10.14924/dermatol.125.2277 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205740622464 ● Search Scopus @ Elsevier (DOI): 10.14924/dermatol.125.2277 (DOI: 10.14924/dermatol.125.2277, CiNii: 1390001205740622464)
15.	Yoshiaki Kubo : Tumorigenesis of the Epidermal Keratinocytes (the second part): Benign Tumor, Carcinoma in situ, The Nishinihon Journal of Dermatology, Vol.77, No.2, 146-152, 2015. (Link to Publication Site) ● Publication site (DOI): 10.2336/nishinihonhifu.77.146 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679279263104 ● Summary page in Scopus @ Elsevier: 2-s2.0-84938283057 (DOI: 10.2336/nishinihonhifu.77.146, CiNii: 1390282679279263104, Elsevier: Scopus)
16.	Yoshiaki Kubo : Molecular carcinogenesis of the skin for development of novel therapy, Shikoku Acta Medica, Vol.70, No.1-2, 19-24, Apr. 2014. (Summary) Skin cancers are considered to develop through accumulations of genetic and/or epigenetic events in normal cells of the skin. Among them, we focus on common skin cancers, including squamous cell carcinoma and melanoma. Many important molecules have been found to be involved in molecular carcinogenesis of these disorders, and some drugs targeting those molecules have been already developed. We review the updates on molecular carcinogenesis with our current works. (Keyword) 黒色腫(遺伝学) / 進化 / 変異 / 腫瘍過程 / 皮膚腫瘍(遺伝学) / 扁平上皮癌(遺伝学) / 膜蛋白質 / 薬物療法 / ras癌原遺伝子蛋白質p21 / GTP Phosphohydrolases / Notch Receptors / 分子標的治療 / HRAS Protein / NRAS Protein / *発癌 / Homo sapiens (Tokushima University Institutional Repository) ● Metadata: 109749 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812441701376 (Tokushima University Institutional Repository: 109749, CiNii: 1050282812441701376)
17.	Yoshiaki Kubo : 【歯科医師のための医学ハンドブック】 (Chapter 9)膠原病・免疫疾患・アレルギー疾患金属アレルギー, Dental Outlook, 137, Apr. 2014.
18.	Yoshiaki Kubo, Yoshihiro Matsudate, Nozomi Fukui, Ayaka Nakasuka, Maiko Sogawa, Mika Oshima, Tomoya Mizutani, Masanobu Otsu, Kazutoshi Murao and Ichiro Hashimoto : Molecular tumorigenesis of the skin., The Journal of Medical Investigation : JMI, Vol.61, No.1-2, 7-14, Feb. 2014. (Summary) Skin tumors are supposed to develop through accumulations of genetic and/or epigenetic events in normal cells of the skin. Among them, we focus on common skin tumors, including benign, seborrheic keratosis, and malignant, squamous cell carcinoma and melanoma. Many important molecules have been detected on the molecular tumorigenesis of each of them to date, and some drugs targeted for their molecules have been already developed. We review updates on the molecular tumorigenesis of these tumors with our current works. (Tokushima University Institutional Repository) ● Metadata: 109490 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.61.7 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24705742 ● Summary page in Scopus @ Elsevier: 2-s2.0-84897947733 (Tokushima University Institutional Repository: 109490, DOI: 10.2152/jmi.61.7, PubMed: 24705742, Elsevier: Scopus)
19.	Yoshiaki Kubo : 【皮膚悪性腫瘍-基礎と臨床の最新研究動向-】有棘細胞癌(日光角化症・Bowen病) 有棘細胞癌の分子生物学と発癌機序有棘細胞癌の遺伝子異常概論, Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.71, 446-450, Aug. 2013. (Keyword) Bowen病(遺伝学); Indoles(治療的利用,毒性・副作用); Sulfonamides(治療的利用,毒性・副作用); 腫瘍抑制蛋白質p53; 変異; 腫瘍過程; 皮膚腫瘍(遺伝学,病因); 扁平上皮癌(遺伝学,病因); ras Proteins; Cyclin-Dependent Kinase Inhibitor p16; Notch Receptors; B-raf癌原遺伝子蛋白質(拮抗物質・阻害物質); 日光角化症(遺伝学) / 分子標的治療(有害作用); Vemurafenib(治療的利用,毒性・副作用) / Homo sapiens
20.	Takeshi Ishigami and Yoshiaki Kubo : The opening of a new age in the treatment of psoriasis : Biologics, Shikoku Acta Medica, Vol.69, No.1-2, 3-6, Apr. 2013. (Summary) Psoriasis is a chronic inflammatory skin disease, which is clinically characterized by scaly erythemas on the whole body. In the fully developed lesions of psoriasis, the histological features have demonstrated epidermal hyperproliferation with infiltration of T lymphocytes in the dermal papillae. Although pre-biological systemic therapies has targeted mainly proliferative keratinocytes and activated T cells, their effects were limited or these therapies could not be applied for patients with severe organ failures. Therefore, more effective agents are expected to improve quality of life (QOL) of patients with psoriasis. Recent studies have showed what kinds of cells, cell surface molecules, and cytokines should play a pivotal role in the pathogenesis of psoriasis. Biological therapies targeting these molecules have proved to be so effective for obstinate lesions of psoriasis. Here, we describe clinical features and pathogenesis of psoriasis, and the characteristics of several conventional and biological therapies for psoriasis in Japan. (Keyword) 感染(化学的誘発) / 乾癬(病因,薬物療法) / モノクローナル抗体(治療的利用,毒性・副作用) / 生物学的製剤(治療的利用,毒性・副作用) / 皮下注射 / Infliximab(治療的利用,毒性・副作用) / Adalimumab(治療的利用,毒性・副作用) / 静脈内注射 / *Ustekinumab(治療的利用,毒性・副作用) / Homo sapiens (Tokushima University Institutional Repository) ● Metadata: 109607 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812441681024 (Tokushima University Institutional Repository: 109607, CiNii: 1050282812441681024)
21.	Yoshiaki Kubo : Tumorigenesis of the Epidermal Keratinocytes, Hifuka No Rinsho, Vol.54, No.13, 1841-4818, Dec. 2012. (Keyword) 表皮角化細胞 / 腫瘍化 / 分子機構 / 脂漏性角化症 / 有棘細胞癌 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522543655515506176 (CiNii: 1522543655515506176)

Proceeding of International Conference:

1.	Kazutoshi Murao and Yoshiaki Kubo : The development of Bowen disease is driven by podoplanin positive cells which can be inhibited by ROCK inhibitor., 1st international societies for investigative dermatology meeting, May 2023.
2.	Yoshihiro Matsudate, Yoshiaki Kubo and Issei Imoto : Chromosomal microarray analysis for the molecular diagnosis of nevoid basal cell carcinoma syndrome and X-linked ichthyosis, International Investigative Dermatology 2018, Orlando, May 2018.
3.	Kazutoshi Murao, H Takeichi, Yoshiaki Kubo and Seiji Arase : Multiple pilocebaseouc systs induced by topical steroid therapy, The 1st Eastern Asia Dermatology Congress, Sep. 2010.

Proceeding of Domestic Conference:

1.	Maki Hosoki, Toyoko Tajima, Mayu Miyagi, Kazuyuki Koike, Yoshiaki Kubo, 答島章公, Mariko Niki, Kenji Hirose and Yoshizo Matsuka : 掌蹠膿疱症性骨関節炎における金属アレルギーの関与と治療効果の検討, 日本皮膚免疫アレルギー学会, Dec. 2024.
2.	Maki Hosoki, Toyoko Tajima, Mayu Miyagi, Masamitsu Ohshima, Mariko Niki, Yoshiaki Kubo and Yoshizo Matsuka : ピアスの金属成分分析と金属アレルギー発症リスクについて, 日本アレルギー学会, Oct. 2024.
3.	Maki Hosoki, Toyoko Tajima, Mayu Miyagi, Mariko Niki, Yoshiaki Kubo and Yoshizo Matsuka : 掌蹠膿疱症における金属アレルギーと歯性感染症について, 日本皮膚免疫アレルギー学会, 199, Dec. 2023.
4.	Maki Hosoki, Toyoko Tajima, 宮城麻衣, Miho Inoue, Mariko Niki, Yoshiaki Kubo and Yoshizo Matsuka : 金属アレルギー患者におけるピアスによる皮膚障害の臨床的検討, 日本アレルギー学会, Vol.72, No.6, 871, Oct. 2023.
5.	Yasushi Sato, Koichi Okamoto, Tetsuji Takayama, Naoki Muguruma, 中山圭子, 大住省三, Yoshiaki Kubo, 内野眞也, 阪埜浩司 and 石川秀樹 : <作業部会委員会企画>Cowden症候群/PTEN hamartoma tumor syndrome (PHTS)の前向き登録コホート研究の概要., 第29回日本遺伝性腫瘍学会学術集会, Jun. 2023.
6.	Yoshiaki Kubo : 有棘細胞癌の発生機序, 第122回日本皮膚科学会総会, Jun. 2023.
7.	Maki Hosoki, Toyoko Tajima, Mayu Miyagi, Miho Inoue, Yoshiaki Kubo and Yoshizo Matsuka : 装飾品に対するニッケル表示の標準化をめざした取り組みについて, 日本皮膚免疫アレルギー学会, Dec. 2022.
8.	山崎佳那子, 祖川麻衣子, Kazutoshi Murao, Yoshiaki Kubo, Masahiro Oura, Takeshi Harada, Shingen Nakamura and Kumiko Kagawa : 骨髄異形成症候群の患者に生じた晩発性皮膚ポルフィリン症の1例, The Nishinihon Journal of Dermatology, Vol.82, No.3, 238-239, Jun. 2020. (Keyword) 骨髄異形成症候群(合併症) Uroporphyrins(尿) ポルフィリン症-晩発性皮膚(合併症,診断) ヒト中年(45~64) 男
9.	山崎佳那子, Mio Yada, Yoshihiro Matsudate, Yoshiaki Kubo and Masanori Tamaki : Sore thumb症候群の1例, The Nishinihon Journal of Dermatology, Vol.82, No.2, 119, Apr. 2020.
10.	Maki Hosoki, Yoshiaki Kubo and Yoshizo Matsuka : 徳島大学歯科用金属アレルギー外来における長期症例の検討, 日本皮膚免疫アレルギー学会, Nov. 2019.
11.	Yoshiaki Kubo, Yoshihiro Matsudate and Kazutoshi Murao : Cowden症候群の皮膚粘膜病変, 第5回消化管ポリポーシス研究会, Jan. 2019.
12.	Maki Hosoki, Yoshiaki Kubo and Yoshizo Matsuka : チタンアレルギーに関する実態調査, 日本皮膚免疫アレルギー学会, Nov. 2018.
13.	Yoshihiro Matsudate and Yoshiaki Kubo : 伴性遺伝性魚鱗癬と長島型掌蹠角化症の併存例, 336回日本皮膚科学会長崎地方会, Sep. 2018.
14.	森あずさ, Nobuhito Naitoh, 山﨑博輝, 林理恵, 坂東紀子, 原田沙希, Hiroshi Kawano, Yuko Toyoda, Hisatsugu Goto, Ryuji Kaji, Yoshiaki Kubo and Yasuhiko Nishioka : 免疫介在性壊死性ミオパチーの1例, 第257回徳島医学会学術集会, Aug. 2018.
15.	Yasuteru Fujino, 野田和克, 村山典聡, Kumiko Tanaka, Shinji Kitamura, Koichi Okamoto, Hiroshi Miyamoto, Yasushi Sato, Naoki Muguruma, Toshiya Okahisa, Tetsuji Takayama, Yoshiaki Kubo, Yoshimi Bando and Seisuke Okamura : 胃巨大ポリープから出血をきたしたCowden病の一例., 第4回消化管ポリポーシス研究会(日本消化器病学会関連研究会), Jan. 2018.
16.	Yoshihiro Matsudate, Yoshiaki Kubo and Issei Imoto : Chromosomal microarray analysis in a case of X-linked ichthyosis with mental retardation, The 42th Annual meeting of the Japanese Society for Investigative Dermatology, Dec. 2017.
17.	Yoshihiro Matsudate, Kazutoshi Murao, Yoshiaki Kubo and 高橋収 : 除草剤ラッソーによる化学熱傷後に生じた多形紅斑の1例, 第47回日本皮膚アレルギー・接触皮膚炎学会総会学術大会, Dec. 2017.
18.	Tetsuya Hida, Ayaka Nakasuka, Mayu Yuasa, Yoshiaki Kubo and Hideya Kashihara : Peristomal pyoderma gangrenosumの1例, 第148回日本皮膚科学会徳島地方会, Dec. 2017.
19.	Kanako Yamasaki, Chiaki Miyamoto, Mio Yada, Yoshihiro Matsudate, Kazutoshi Murao, Yoshiaki Kubo and Taichi Murakami : 急速に腎障害が進行したクリオグロブリン血症性血管炎の1例, 第69回日本皮膚科学会西部支部学術大会, Oct. 2017.
20.	Makoto Tobiume, Shun Morizumi, 鈴江涼子, Tetsuya Hida, Hirokazu Ogino, Kenji Ohtsuka, Hisatsugu Goto, Hisanori Uehara, Yoshiaki Kubo and Yasuhiko Nishioka : BRAF 陽性肺原発悪性黒色腫の1例, 第58回日本呼吸器学会中国・四国地方会, Oct. 2017.
21.	大西一, Shun Morizumi, Tetsuya Hida, Yoshihiro Matsudate, Hirokazu Ogino, Kenji Ohtsuka, Makoto Tobiume, Hisatsugu Goto, Hisanori Uehara, Yoshiaki Kubo and Yasuhiko Nishioka : BRAF陽性肺原発悪性黒色腫の1例, 第255回徳島医学会学術集会, Aug. 2017.
22.	Mayu Yuasa, Kazutoshi Murao and Yoshiaki Kubo : ニボルマブ投与中に中枢性副腎機能不全を生じた悪性黒色腫の1例, 日本皮膚悪性腫瘍学会, Jul. 2017.
23.	Masanobu Ootsu, Kazutoshi Murao, Ken-ichi Suga, Ryuji Nakagawa, Shoji Kagami, Issei Imoto and Yoshiaki Kubo : ADAM17欠損症を疑った1例, 第116回日本皮膚科学会総会, Jun. 2017.
24.	Mio Yada, Kanako Yamasaki, Kazutoshi Murao, Yoshiaki Kubo, Yuta Arai and Seiji Iwamoto : 日本紅斑熱患者に発症した特発性腸腰筋血腫の1例, 第116回日本皮膚科学会総会, Jun. 2017.
25.	Yoshihiro Matsudate, 山﨑佳那子, Kazutoshi Murao and Yoshiaki Kubo : ラミニンγ1に対する自己抗体も有した線状IgA/IgG水疱性皮膚症の1例, 第116回日本皮膚科学会総会, Jun. 2017.
26.	Yoshiaki Kubo : 加齢に伴う皮膚癌:蓄積した遺伝子異常と分子標的治療薬, 第13回加齢皮膚医学研究会, Apr. 2017.
27.	Tetsuya Hida, Kenji Hirose, Kazutoshi Murao, Hirokazu Takechi, 氏家英之 and Yoshiaki Kubo : 乳癌を合併した後天性表皮水疱症の1例, 第79回日本皮膚科学会沖縄地方会, Jan. 2017.
28.	岩坂麻衣子, Mio Yada, 宮本千暁, Yoshihiro Matsudate, Yoshiaki Kubo and 佐川禎昭 : 疣贅状表皮発育異常症の1例, Dec. 2016.
29.	Yoshihiro Matsudate, Kazutoshi Murao, 浦野芳夫 and Yoshiaki Kubo : 点滴留置針外套による接触皮膚炎の3例, 第46回日本皮膚アレルギー・接触皮膚炎学会総会学術大会, Nov. 2016.
30.	Naoto Okada, 御牧夕紀子, 桑原絵美, Yoshihiro Matsudate, Shinji Abe, Chiemi Sato, Yoshiaki Kubo, Keisuke Ishizawa and Kazuyoshi Kawazoe : ニボルマブ投与による末梢血リンパ球比率の変化が副作用発現及び治療効果に与える影響, 第26回日本医療薬学会年会, Sep. 2016.
31.	宮本千暁, Mio Yada, Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : アザチオプリンによる急性汎発性発疹性膿疱症の1例, Jun. 2016.
32.	Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : 偽癌性増殖を伴った原発性皮膚CD30陽性リンパ増殖症の1例, 第115回日本皮膚科学会総会, Jun. 2016.
33.	Mio Yada, Kenji Hirose, Kazutoshi Murao, Yoshiaki Kubo, Kazuhide Mineda, Ichiro Hashimoto and Shin-ichi Ansai : 鼻尖部に生じた脂腺癌の1例, 第32回日本皮膚悪性腫瘍学会学術大会, May 2016.
34.	Mayu Yuasa, Kazutoshi Murao and Yoshiaki Kubo : 上肢のBlaschko線に沿って生じた硬化性苔癬の一例, 日本皮膚科学会, May 2016. (Keyword) 硬化性苔癬
35.	Mio Yada, Kenji Hirose, Kazutoshi Murao, Yoshiaki Kubo, Kazuhide Mineda, Ichiro Hashimoto and Shin-ichi Ansai : 鼻尖部に生じた脂腺癌の1例, 第169回日本皮膚科学会山口地方会, Mar. 2016.
36.	Yoshihiro Matsudate, Kazutoshi Murao, Yoshiaki Kubo and Issei Imoto : Genetic diagnosis of the nevoid basal cell carcinoma syndrome using next-generation sequencer, 第40回日本研究皮膚科学会, Dec. 2015.
37.	Kenji Hirose, Yoshiaki Kubo, Mariko Egawa and 鈴木正和 : TNF-α抗体加療中に両眼性ぶどう膜炎を発症した尋常性乾癬の1例, 第30回日本乾癬学会, Sep. 2015.
38.	Kenji Hirose, 仁木真理子, Tomoya Mizutani, 中村宗夫, Yoshiaki Kubo, 榊哲彦, 山田裕一 and 小田義直 : Ossifying fibromyxoid tumor の1例, 第31回日本皮膚悪性腫瘍学会, Jul. 2015.
39.	柴田恵理子, 田蒔昌憲, 小野広幸, 上田紗代, Sakiya Yoshimoto, Taichi Murakami, Motokazu Matsuura, Kojiro Nagai, Hideharu Abe, Toshio Doi, Mayu Yuasa and Yoshiaki Kubo : 光線療法に対して難治性でIFN-γを使った菌状息肉症の一例, 第60回日本透析医学会学術集会・総会, Jun. 2015.
40.	Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : 後天性リンパ管腫を契機に診断に至ったCowden病の1家系, 第114回日本皮膚科学会総会, May 2015.
41.	Yoshiaki Kubo : 脈管系母斑症の概要, 第114回日本皮膚科学会総会, May 2015.
42.	Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : ミドリンPとヒアレインミニ点眼液による接触皮膚炎の1例, 第44回日本皮膚アレルギー・接触皮膚炎学会学術大会, Nov. 2014.
43.	Maki Hosoki, Toyoko Tajima and Yoshiaki Kubo : 1, Journal of Environmental Dermatology and Cutaneous Allergology, Vol.8, No.5, 497, Nov. 2014.
44.	Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : ペメトレキセド投与により脂漏性角化症，アクロコルドンに限局して紅斑を生じた2例, 第66回日本皮膚科学会西部支部学術大会, Nov. 2014.
45.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, Toshiaki Hashimoto, Yoshiaki Kubo and Masayuki Azuma : 頬部脂肪萎縮性脂肪織炎の1例, 第62回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2014.
46.	Kazutoshi Murao and Yoshiaki Kubo : 静脈怒張部に一致して白斑を生じた尋常性白斑の2例, 第128回山陰・第24回島根合同開催地方会, Aug. 2014.
47.	祖川麻衣子, Yoshihiro Matsudate, Kazutoshi Murao, Yoshiaki Kubo and Mika Sakaki : Primary cutaneous follicle center lymphomaの1例, 第113回日本皮膚科学会総会, May 2014.
48.	Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : 多数のcutaneous keratocystsを伴った母斑性基底細胞癌症候群の1例, 第113回日本皮膚科学会総会, May 2014.
49.	Kazutoshi Murao, 中須賀彩香 and Yoshiaki Kubo : アトピー性皮膚炎患者に生じ，HPV16が検出された多発性Bowen病の1例, 第368回日本皮膚科学会福岡地方会, Mar. 2014.
50.	Kazutoshi Murao, 祖川麻衣子 and Yoshiaki Kubo : HPV16を検出した足背部Bowen病の1例, 第137回日本皮膚科学会宮崎地方会, Mar. 2014.
51.	Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : Rhizomucor variabilisによる皮膚ムーコル症の1例, 第65回日本皮膚科学会西部支部学術大会, Nov. 2013.
52.	Kazutoshi Murao and Yoshiaki Kubo : 有棘細胞癌の分子機構, 第65回日本皮膚科学会西部支部学術大会, Nov. 2013.
53.	Maki Hosoki, Toyoko Tajima and Yoshiaki Kubo : ピアスと金属アレルギー, Journal of Environmental Dermatology and Cutaneous Allergology, Vol.7, No.5, 457, Nov. 2013.
54.	Nozomi Fukui, Yoshiaki Kubo, Kazutoshi Murao and 他1名 : アリルイソプロピルアセチル尿素による多発性固定薬疹の1例, 第43回日本皮膚アレルギー・接触皮膚炎学会総会学術大会, Nov. 2013.
55.	Nozomi Fukui, Yoshiaki Kubo, Kazutoshi Murao and 他2名 : Papular acantholytic dyskeratosis of the vulvaの1例, 第65回日本皮膚科学会西部支部学術大会, Nov. 2013.
56.	Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : Folliculotropic mycosis fungoidesの1例, 第29回日本皮膚悪性腫瘍学会学術大会, Aug. 2013.
57.	Yoshihiro Matsudate, Kazutoshi Murao, Yoshiaki Kubo and Jun Kishi : 刺青部の肉芽腫病変を契機に診断に至ったサルコイドーシスの1例, 第112回日本皮膚科学会総会, Jun. 2013.
58.	Kazutoshi Murao, Mika Oshima and Yoshiaki Kubo : ビタミンD3軟膏外用療法が奏効したverrucous skin lesions on the feet in diabetic neuropathyの1例, 第4回日本臨床皮膚科医会四国ブロック総会・学術大会, May 2013.
59.	Tomoya Mizutani, 井上奈津子, Kazutoshi Murao, Yoshiaki Kubo and Takeshi Ishigami : 脳転移を伴った直腸原発悪性黒色腫の1例, 第81回日本皮膚科学会茨城地方会, Mar. 2013.
60.	Yoshihiro Matsudate, 仙崎聖子, Kazutoshi Murao and Yoshiaki Kubo : Ichthyosiform mycosis fungoidesの1例, 第64回日本皮膚科学会西部支部学術大会, Oct. 2012.
61.	Ayaka Takahashi, Hiroyasu Okazaki, Jun Kishi, Yuko Toyoda, Toshifumi Tezuka, Yoshihiro Matsudate, Souji Kakiuchi, Hisatsugu Goto, Masaki Hanibuchi, Yoshiaki Kubo and Yasuhiko Nishioka : 刺青部分に肉芽腫性変化を起こしたサルコイドーシスの1例, 第245回徳島医学会学術集会, Jul. 2012.
62.	Yoshihiro Matsudate, 仙崎聖子 and Yoshiaki Kubo : ダビガトラン(プラザキサ®)が奏効したリベド血管症の1例, 第137回日本皮膚科学会徳島地方会, May 2012.
63.	Mio Machida, Kenji Hirose, Kazutoshi Murao, Yoshiaki Kubo, 浦野芳夫 and Shin-ichi Ansai : Folliculosebaceous cystic hamartomaの所見を伴った色素性母斑の1例, 第63回日本皮膚科学会西部支部学術大会, Oct. 2011.
64.	Maki Hosoki, Toyoko Satsuma and Yoshiaki Kubo : ニッケル含有ピアスによる金属アレルギー発症の危険性について, Journal of environmental Dermatology and Cutaneous allergology, Vol.3, 303, Jul. 2011.
65.	Maki Hosoki and Yoshiaki Kubo : 歯科用金属アレルギーとピアスの関係について, Journal of environmental Dermatology and Cutaneous allergology, Vol.4, 148, Jul. 2011.
66.	Mio Machida, Yasutoshi Hida, Kazutoshi Murao, Yoshiaki Kubo, 岸昌美 and Saburo Sone : 淡黄色小結節を伴ったChurg-Strauss症候群の1例, 第57回日本皮膚科学会高知地方会, Feb. 2011.
67.	Yoshihiro Matsudate, Takeshi Ishigami, Yasutoshi Hida, Yoshiaki Kubo, Seiji Arase, Ichiro Hashimoto, Hideki Nakanishi and 高橋収 : 急速に増大した上眼瞼メルケル細胞癌の1例, 第50回日本皮膚科学会高知地方会 -佐野栄紀教授就任記念-, Sep. 2007.
68.	Kazuya Matsumoto, Hideki Nakanishi, 浦野芳夫, Yoshiaki Kubo, 福原耕作 and Seiji Arase : 乳房外paget病のras遺伝子の変異, 第6回日本形成外科学会基礎学術集会, Oct. 1997.
69.	Kazuya Matsumoto, Hideki Nakanishi, 庄野佳孝, Yoshiaki Kubo, 浦野芳夫 and Seiji Arase : Apert症候群におけるFGFレセプター2遺伝子異常, 第5回日本形成外科学会基礎学術集会, Oct. 1996.
70.	Kazuya Matsumoto, 浦野芳夫, Yoshiaki Kubo, Hideki Nakanishi and Seiji Arase : Apert症候群におけるFGFレセプター2遺伝子異常, 第3回分子皮膚科学フォーラム, Jul. 1996.

Et cetera, Workshop:

1.	Kazutoshi Murao, Yoshiaki Kubo and Kazuhide Mineda : 摘出後に衛星病巣を生じた血管拡張性肉芽腫の1例, 第196回日本皮膚科学会鹿児島地方会, Mar. 2024.
2.	Kazutoshi Murao, 中野里穂, Yoshiaki Kubo and 横田綾 : 下腿に生じた化膿性汗腺炎の1例, 第81回日本皮膚科学会高知地方会, Oct. 2023.
3.	Kanako Yamasaki, 白井宏美, 遠藤理子, 宮本翔子, Mariko Niki, Kazutoshi Murao, Yoshiaki Kubo, 藤本篤夫, 榊哲彦, 田中美緒, 田中龍星 and 丸山治彦 : 多数の虫体を認め治療に難渋しているマンソン孤虫症の1例, 第75回日本皮膚科学会西部支部学術大会, Sep. 2023.
4.	堀優子, Kazutoshi Murao and Yoshiaki Kubo : 一般用創傷被覆剤(キズパワーパッド)による接触蕁麻疹症候群の1例, 第75回日本皮膚科学会西部支部学術大会, Sep. 2023.
5.	Kazutoshi Murao, Kanako Yamasaki and Yoshiaki Kubo : すだちの棘による刺創部に生じたintralymphatic histiocytosisの1例, 第153回日本皮膚科学会広島地方会, Sep. 2023.
6.	遠藤理子, 武市浩美, Kazutoshi Murao and Yoshiaki Kubo : 単発性pseudoatrophic maculeの1例, 第141回日本皮膚科学会山陰地方会, Sep. 2023.
7.	Kazutoshi Murao, Kanako Yamasaki, 堀優子 and Yoshiaki Kubo : 長期間narrow-band UVB治療を行っていた乾癬患者に生じた多発性Bowen病の1例, 第39回日本皮膚悪性腫瘍学会学術大会, Aug. 2023.
8.	宮本翔子, 遠藤理子, 佐藤有莉乃, Hiromichi Kawashima, Kazutoshi Murao, Yoshiaki Kubo and Hirokazu Ogino : 抗PD-L1抗体投与中に発症した表皮の全層壊死を伴う苔癬様皮疹の1例, 第14回日本臨床皮膚科医会四国ブロック, Jul. 2023.
9.	堀優子, Mariko Niki, Hiromichi Kawashima, 木下華子, Kazutoshi Murao, Yoshiaki Kubo, 山本綾香, 石谷祐紀 and 玉置俊輔 : セクキヌマブ投与中可能性胸鎖関節炎を発症した乾癬性関節炎の2例, 第122回日本皮膚科学会総会, Jun. 2023.
10.	宮本翔子, 遠藤理子, 佐藤有莉乃, Hiromichi Kawashima, Kazutoshi Murao, Yoshiaki Kubo and Hirokazu Ogino : 抗PD-L1抗体投与中に生じた表皮の全層性壊死を伴う苔癬様皮疹の1例, 第158回日本皮膚科学会徳島地方会, May 2023.
11.	遠藤理子, 岩脇文香, Hiromichi Kawashima, Kazutoshi Murao, Yoshiaki Kubo and 長江哲夫 : Benign cephalic histiocytosisの1例, 第157回日本皮膚科学会徳島地方会, Nov. 2022.
12.	木下華子, Kazutoshi Murao and Yoshiaki Kubo : 多形慢性痒疹における血清TARC値の検討:TARC値は丘疹紅皮症との鑑別に有用である, 第74回日本皮膚科学会西部支部学術大会, Oct. 2022.
13.	宮本翔子, Kazutoshi Murao and Yoshiaki Kubo : 右外果に生じた後天性真皮メラノサイト―シスの1例, 第75回日本皮膚科学会愛媛地方会, Oct. 2022.
14.	Kazutoshi Murao, 佐藤有莉乃 and Yoshiaki Kubo : Cutaneous collagenous vasculopathyの1例, 第37回日本皮膚科学会島根地方会, Aug. 2022.
15.	山崎佳那子, 湊優子, 中島美世, Mariko Niki, Kazutoshi Murao, Yoshiaki Kubo, 小川瑛 and Yuya Yamashita : JAK阻害薬投与中に発症した皮膚クリプトコッカス症の1例, 第121回日本皮膚科学会総会, Jun. 2022.
16.	田蒔舞子, 岩脇文香, Kazutoshi Murao, Yoshiaki Kubo, Yasutoshi Hida, 中村秀樹 and 夏賀健 : Kindler症候群の1例, 第121回日本皮膚科学会総会, Jun. 2022.
17.	佐藤有莉乃, 六車あずさ, 岩脇文香, Kanako Yamasaki, Kazutoshi Murao, 田蒔舞子, Mariko Niki and Yoshiaki Kubo : 当科で最近経験した頭部血管肉腫の4例, 日本皮膚科学会熊本地方会, Mar. 2022.
18.	Kazutoshi Murao and Yoshiaki Kubo : 顔面に小丘疹を多発し，組織学的に肉芽腫を呈した小児例, 第150回日本皮膚科学会広島地方会, Feb. 2022.
19.	中島美世, Mayu Yuasa, Kazutoshi Murao and Yoshiaki Kubo : 硫酸クロピドグレルによる薬疹の1例, 日本皮膚科学会高知地方会, Jan. 2022.
20.	岩脇文香, 山﨑佳那子, 中島美世, Kazutoshi Murao, Yoshiaki Kubo and Masahiro Oura : シアナミドによる薬疹を契機に丘疹-紅皮症を生じたHTLV-1キャリアの1例, 第73回日本皮膚科学会西部支部学術大会, Oct. 2021.
21.	山崎佳那子, 佐藤有莉乃, Mariko Niki, Kazutoshi Murao and Yoshiaki Kubo : 全身に強い色素沈着を伴い，経過中に水疱性類天疱瘡を併発し，CyAが著効した好酸球性環状紅斑(EAE)の1例, 第73回日本皮膚科学会西部支部学術大会, Oct. 2021.
22.	Mariko Niki, Kazutoshi Murao, Yoshiaki Kubo, 吉野真理子 and 石井文人 : 疥癬が先行し抗ラミニンγ1抗体と抗ラミニン332抗体を検出した類天疱瘡の1例, 第73回日本皮膚科学会西部支部学術大会, Oct. 2021.
23.	Kazutoshi Murao and Yoshiaki Kubo : Podoplanin陽性細胞はBowen病のtumor-initiating cellである, 第28回四国四大学講演会, Jul. 2021.
24.	山﨑佳那子, 森あずさ, 木下華子, Rie Hayashi, Kazutoshi Murao, Yoshiaki Kubo and 安齋眞一 : ALK陽性を示したepithelioid fibrous histiocytomaの1例, 第120回日本皮膚科学会総会, Jun. 2021.
25.	Hiromichi Kawashima, 阿河弘和, Rie Hayashi, Mariko Niki, Kazutoshi Murao, Mio Yada and Yoshiaki Kubo : 下腿の創傷を契機に診断した歯周型Ehlers-Danlos症候群の1例, 第120回日本皮膚科学会総会, Jun. 2021.
26.	山﨑佳那子, Rie Hayashi, Kazutoshi Murao and Yoshiaki Kubo : 下腿蜂窩織炎様の臨床像で再発した節外性 NK/T 細胞リンパ腫の 1 例, 第72回日本皮膚科学会西部支部学術大会, Oct. 2020.
27.	田蒔舞子, Mayu Yuasa, Kazutoshi Murao, Yoshiaki Kubo and 矢野由香 : 踵部に黒色壊死した潰瘍を生じ，好中球性皮膚症と考えた 1 例, 第72回日本皮膚科学会西部支部学術大会, Oct. 2020.
28.	Mariko Niki, 岩脇文香, Kazutoshi Murao and Yoshiaki Kubo : 骨髄移植後の慢性 GVHD 経過中に頭部に多発した有棘細胞癌の 1 例, 第119回日本皮膚科学会総会, Jun. 2020.
29.	山﨑佳那子, 宮本千暁, 祖川麻衣子, Kazutoshi Murao and Yoshiaki Kubo : 出生時より経過を追い 2 歳時に診断に至った Netherton 症候群の 1 例, 第119回日本皮膚科学会総会, Jun. 2020.
30.	岩脇文香, Mariko Niki, 田蒔舞子, Kazutoshi Murao and Yoshiaki Kubo : 頭部に生じたchemical leukodermaの2例, 第152回日本皮膚科学会徳島地方会, Dec. 2019.
31.	Kazutoshi Murao, 小杉知里 and Yoshiaki Kubo : Podoplanin expression in Bowen disease: positive cells can be tumor-initiating cells of Bowen disease, The 44th annual meeting of the Japanese society for investigative dermatology, Nov. 2019.
32.	Mariko Niki, Ayaka Nakasuka, Kazutoshi Murao and Yoshiaki Kubo : Linear cutaneous lupus erythematosus (LCLE)治癒後に，全身性エリテマトーデスを発症した1例, 第71回日本皮膚科学会西部支部学術大会, Sep. 2019.
33.	山﨑佳那子, 祖川麻衣子, Kazutoshi Murao and Yoshiaki Kubo : 骨髄異形成症候群の患者に生じた晩発性皮膚ポルフィリン症の1例, 第71回日本皮膚科学会西部支部学術大会, Sep. 2019.
34.	Tetsuya Hida, Kazutoshi Murao and Yoshiaki Kubo : ウステキヌマブで効果不十分な尋常性乾癬に対するグセルクマブへのバイオスイッチによる有効性の検討, 第34回日本乾癬学会学術大会, Aug. 2019.
35.	水口誠人, 坂本恵子, 山崎裕行, Yutaro Yamashita, Ichiro Hashimoto, 松立吉弘, Yoshiaki Kubo and 安斎眞一 : 悪性黒色腫と鑑別を要した脂漏性角化症を伴う腰部脂腺癌の1例, 第24回徳島形成外科集談会, Aug. 2019.
36.	宮本千暁, 祖川麻衣子, Kazutoshi Murao and Yoshiaki Kubo : 前胸部に多発する紅色結節を呈したEBV陽性びまん性大細胞型B細胞リンパ腫の1例, 第118回日本皮膚科学会総会, Jun. 2019.
37.	Mayu Yuasa, Kazutoshi Murao, Yoshiaki Kubo and 四方英二 : 外傷性頚部動静脈瘻の1例, 第118回日本皮膚科学会総会, Jun. 2019.
38.	雲財崇, Mio Yada, 宮本千暁, Kazutoshi Murao and Yoshiaki Kubo : 転移性を疑ったが原発巣が見つからなかったmucinous carcinomaの1例, 第35回日本皮膚悪性腫瘍学会学術大会, May 2019.
39.	Kazutoshi Murao, 祖川麻衣子, Mio Yada and Yoshiaki Kubo : 末梢性T細胞リンパ腫患者に生じたinsect bite-like reactionの1例, 第275回日本皮膚科学会岡山地方会, Sep. 2018.
40.	Kazutoshi Murao, Chisato Kosugi and Yoshiaki Kubo : Bowen病におけるpodoplanin発現の検討, 第25回四国四大学皮膚科講演会, Jul. 2018.
41.	Mayu Yuasa, Kazutoshi Murao, Yoshiaki Kubo and Kaoru Keyama : 頭部に生じた原発巣不明のadenocarcinomaの1例, 第34回日本皮膚悪性腫瘍学会学術大会, Jul. 2018.
42.	Masanobu Ootsu, 中島美世, Kazutoshi Murao, Yoshiaki Kubo and Masami Morimoto : Li-Fraumeni症候群に生じた多発性Bowen病の1例, 第117回日本皮膚科学会総会, May 2018.
43.	Mayu Yuasa, Kazutoshi Murao and Yoshiaki Kubo : バラシクロビル内服によって病勢を制御できた再発性多形滲出性紅斑の1例, 第117回日本皮膚科学会総会, May 2018.
44.	Kazutoshi Murao, 木下華子 and Yoshiaki Kubo : 乳頭部に生じた尖圭コンジローマの1例, 第34回日本臨床皮膚科医会総会・臨床学術大会, Apr. 2018.
45.	中島美世, Ayaka Nakasuka, Kazutoshi Murao and Yoshiaki Kubo : シクロスポリン投与中に脂腺増殖症を多発した2例, 第148回日本皮膚科学会徳島地方会, Dec. 2017.
46.	祖川麻衣子, Tetsuya Hida, Kazutoshi Murao, Yoshiaki Kubo and 長江哲夫 : Necrobiotic xanthogranulomaの1例, 日本皮膚科学会第69回西部支部総会, Oct. 2017.
47.	祖川麻衣子, 木下華子, Kenji Hirose and Yoshiaki Kubo : 長島型掌蹠角化症の1例, 第144回日本皮膚科学会徳島地方会, Dec. 2015.
48.	Masanobu Ootsu, 木下華子, Kazutoshi Murao, 吉岡正太郎, Junichiro Satomi, Shinji Nagahiro and Yoshiaki Kubo : 頭部IVR施行後に脱毛を生じた1例, 日本皮膚科学会第143回宮崎地方会, Nov. 2015.
49.	Kenji Hirose, 宮本千暁, Kazutoshi Murao, Yoshiaki Kubo, Hirohisa Ogawa and 藤本篤夫 : 顔面に広範囲に多発した偽リンパ腫の1例, 第67回日本皮膚科学会西部支部学術大会, Oct. 2015.
50.	Rie Yamamura, Kenji Hirose, Kazutoshi Murao, Yoshiaki Kubo and 坂尾佳久 : シクロスポリン内服が有効であった小児剣創状強皮症の1例, 第67回日本皮膚科学会西部支部学術大会, Oct. 2015.
51.	幸田舞子, Nozomi Fukui, Kazutoshi Murao and Yoshiaki Kubo : 症状が再燃，遷延し，治療に難渋した薬剤過敏症症候群の1例, 第114回日本皮膚科学会総会，横浜, May 2015.
52.	Mayu Yuasa, Kazutoshi Murao and Yoshiaki Kubo : 糖尿病性腎症・網膜症患者に生じた菌状息肉症の1例, The Japanese Journal of Dermatology, Vol.125, No.4, 945, Apr. 2015. (Keyword) Interferon Gamma(治療的利用)
53.	雲財崇, 新井悠太, 松永直樹, Mayu Yuasa, Kazutoshi Murao and Yoshiaki Kubo : 糖尿病性腎症・網膜症患者に生じた菌状息肉症の1例, Shikoku Acta Medica, Vol.71, No.1-2, 55-56, Apr. 2015. (Keyword) Interferon Gamma(治療的利用)
54.	Mayu Yuasa, Rie Yamamura, Kazutoshi Murao and Yoshiaki Kubo : 陰茎に生じたcalciphylaxisの1例, 第142回日本皮膚科学会徳島地方会, Dec. 2014.
55.	祖川麻衣子, Yoshihiro Matsudate, Kazutoshi Murao and Yoshiaki Kubo : 尋常性乾癬の患者に掃除た疱疹状天疱瘡の1例, 第21回四国四大学皮膚科研究会, Jun. 2014.
56.	Tomoya Mizutani, Takeshi Ishigami, Kazutoshi Murao and Yoshiaki Kubo : Multiple cutaneous cavernous malformations associated with cerebral cavernous malformations due to a germline mutation of the PDCD10 gene, The 37th Annural Meeting of the Japanese Society for Investigative Dermatology, Dec. 2012.
57.	Kazutoshi Murao and Yoshiaki Kubo : Human papillomavirus infection in Bowen disease, The 37th annual meeting of the Japanese society of investigative dermatology, Dec. 2012.
58.	仁木真理子, Kazutoshi Murao, Yoshiaki Kubo, Ichiro Hashimoto, 柏木圭介, 仙崎雄一 and Hideki Nakanishi : リンパ節転移を伴い，巨大な腫瘍を呈したmucinous carcinoma of the skinの1例, 第138回日本皮膚科学会徳島地方会, Dec. 2012.
59.	Mika Oshima, Kazuhiro Furukita, Kazutoshi Murao and Yoshiaki Kubo : 拒食症患者に見られた壊死性遊走性紅斑様皮疹の1例, 第138回日本皮膚科学会徳島地方会, Dec. 2012.
60.	Natsuko Inoue, Kazutoshi Murao, Yoshiaki Kubo and Hiroyoshi Watanabe : Kaposiform hemangioendothelioma1, 第64回日本皮膚科学会西部支部学術大会, Oct. 2012.
61.	Kazutoshi Murao and Yoshiaki Kubo : 指趾短縮症をともなったwoolly hair nevusの1例, 第63回日本皮膚科学会中部支部学術大会, Oct. 2012.
62.	Tomoya Mizutani, Kazutoshi Murao and Yoshiaki Kubo : 神経性食思不振症の女性に生じた痛風結節, 第362回日本皮膚科学会福岡地方会, Sep. 2012.
63.	緋田哲也, Yoshihiro Matsudate, Kazutoshi Murao, Yoshiaki Kubo and Yasutoshi Hida : 脂漏性角化症病巣内に発症したBowen病の1例, 第28回日本皮膚悪性腫瘍学会学術大会, Jun. 2012.
64.	Mika Oshima, 仙崎聖子, Takeshi Ishigami, Kazutoshi Murao and Yoshiaki Kubo : Radiation-recall phenomenonを伴った性腺刺激ホルモン(LH-RH)アンタゴニスト製剤による薬疹の1例, 第19回四国四大学皮膚科研究会, Jun. 2012.
65.	Rie Yamamura, Kazuhiro Furukita, 緋田哲也, Takeshi Ishigami, Kazutoshi Murao and Yoshiaki Kubo : 広範な脱毛を呈した瘢痕性脱毛症の1例, 第111回日本皮膚科学会総会, Jun. 2012.
66.	Takeshi Ishigami, Kazuhiro Furukita, Kazutoshi Murao and Yoshiaki Kubo : 下大静脈形成不全を認めた難治性下腿潰瘍の1例, 第111回日本皮膚科学会総会, Jun. 2012.
67.	緋田哲也, Mika Oshima, Kazutoshi Murao, Yoshiaki Kubo and Tatsuro Miyamoto : 壊死性強膜炎を伴った壊疽性膿皮症の1例, 第111回日本皮膚科学会総会, Jun. 2012.
68.	Takeshi Ishigami, Kazuhiro Furukita, Kazutoshi Murao, Yoshiaki Kubo and Yasutoshi Hida : ブシラミンによる薬剤誘発性ループスの2例, 第137回日本皮膚科学会徳島地方会, May 2012.
69.	Kazuhiro Furukita, Rie Yamamura, Kazutoshi Murao and Yoshiaki Kubo : 象皮病の1例, 第51回日本皮膚科学会香川地方会, Mar. 2012.
70.	Takeshi Ishigami, Yasutoshi Hida, Kazutoshi Murao, Yoshihiro Matsudate and Yoshiaki Kubo : The involvement of fibroblast growth factor receptor signaling pathways in dermatofibroma and dermatofibrosarcoma protuberans., The 36th Annual Meeting of the Japanese Society for Investigative Dermatology, Dec. 2011.
71.	Kazutoshi Murao and Yoshiaki Kubo : 尋常性乾癬，円形脱毛症を合併した再発性多発性軟骨炎の1例, 第62回日本皮膚科学会中部支部学術大会, Nov. 2011.
72.	Osamu Miyajima, Kazutoshi Murao, Yoshiaki Kubo and Kyoko Takeuchi : B細胞リンパ腫に合併したbullous smyloidosisの1例, 第63回日本皮膚科学会西部支部学術大会, Oct. 2011.
73.	Mika Oshima, Seiko Senzaki, Takeshi Ishigami, Kazutoshi Murao and Yoshiaki Kubo : Recall phenomenonを呈したLH-RHアゴニスト製剤による薬疹の1例., 第63回日本皮膚科学会西部支部学術大会, Oct. 2011.
74.	Takeshi Ishigami, Yasutoshi Hida, Kazutoshi Murao and Yoshiaki Kubo : 間葉系腫瘍における線維芽細胞増殖因子受容体(FGFR)経路の役割, 第18回四国四大学皮膚科研究会, May 2011.
75.	Tomoya Mizutani, Takeshi Ishigami, Kazutoshi Murao and Yoshiaki Kubo : Overlap症候群に合併した皮膚石灰沈着症の1例, 第110回日本皮膚科学会総会, Apr. 2011.
76.	Osamu Miyajima, 鉄谷真由, Takeshi Ishigami, Kazutoshi Murao and Yoshiaki Kubo : 抗ラミニン332型粘膜類天疱瘡を合併した水疱性類天疱瘡の1例, 第110回日本皮膚科学会総会, Apr. 2011.
77.	Mika Oshima, Kazutoshi Murao, Takeshi Ishigami, Yoshiaki Kubo and Seiji Arase : 塩酸ニフェカラントによる皮膚障害の1例., 第134回日本皮膚科学会徳島地方会, Jan. 2011.
78.	Takeshi Ishigami, Yoshiaki Kubo, Kenji Hirose, Yasutoshi Hida and Kazutoshi Murao : 下口唇に皮膚有棘細胞癌を生じた色素性乾皮症バリアント型の1例, 第32回日本光医学・光生物学会, Jul. 2010.
79.	Kazutoshi Murao, 福本実扶子, Yoshiaki Kubo, Hiroyoshi Watanabe and Seiji Arase : 骨髄移植後に汎発性脱色素斑を生じた1例, 第34回日本小児皮膚科学会学術大会, Jul. 2010.
80.	鉄谷真由, 石上剛史, Kazutoshi Murao, Yoshiaki Kubo and Seiji Arase : 手掌に生じたBowen病の1例, 第109回日本皮膚科学会総会, Apr. 2010.
81.	Tomoyuki Yuasa, Seiji Yano, Yasuhiko Nishioka, Yoshiaki Kubo, Masayuki Takahashi, Hiroyoshi Nakatsuji, Hisao Nagaya, Hiro-omi Kanayama, Seiji Arase, Saburo Sone and Yousuke Ebina : Soluble insulin receptor ectodomain in the plasma is a possible broad-spectrum tumor marker, 第68回日本癌学会学術総会記事, 450, Oct. 2009.
82.	Tomoyuki Yuasa, Toshiyuki Obata, Seiji Yano, 岡本英治, Yasuhiko Nishioka, Yoshiaki Kubo, Masayuki Takahashi, Hiroyoshi Nakatsuji, Hisao Nagaya, Hiro-omi Kanayama, Seiji Arase, Saburo Sone and Yousuke Ebina : Soluble insulin receptor ectodomain level was elevated in the plasma of cancer patients, 第29回日本分子腫瘍マーカー研究会プログラム, 70-71, Sep. 2009.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Reprogramming of epidermal keratinocytes and the process of tumorigenesis (Project/Area Number: 16K10159 )
Genomic instabilities and tumorigenesis in epidermal keratinocytes (Project/Area Number: 25461696 )
Epigenetics abnormalities andescape fromthe immune system in epidermal keratinocytes (Project/Area Number: 22591224 )
The regulation and abnormalities of the epigenetics on epidermal keratinocytes (Project/Area Number: 19591309 )
Molecular abnormalities of cell cycle regulations in epidermal keratinocytes for the clinical applications (Project/Area Number: 17591173 )
Induction of p16^<INK4a> gene expression by oncogenic stress is involved in the tumor suppression mechanism of skin cancer (Project/Area Number: 16390318 )
A study of sentinellymph nodes for malignant tumor of Head and Neck (Project/Area Number: 15591996 )
The research for the classification by molecular biology and the development of a novel therapy in squamous cell carcinomas of the skin (Project/Area Number: 15591180 )
The multistep process in skin carcinogenesis (Project/Area Number: 13670888 )
表皮ケラチノサイトにおけるp16＾＜INK4a＞及びp19＾＜ARF＞の機能 (Project/Area Number: 09770635 )
結節性硬化症に発生した皮膚腫瘍、及び孤発性皮膚腫瘍におけるTSC2遺伝子の解析 (Project/Area Number: 08770658 )
DNA損傷に対する汗孔角化症細胞の反応性の研究(p53発現誘導の検討) (Project/Area Number: 08670971 )
Isolation of the predisposing gene of the Eker rat model of hereditary renal cell carcinoma (Project/Area Number: 06454719 )
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Professor : Kubo, Yoshiaki

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)