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研究活動

専門分野

麻酔科学 (Anesthesiology)

研究テーマ

著書・論文

著書:

1.富山 芳信, 大下 修造 :
麻酔中の循環系の変化,
真興交易(株)医書出版部, 東京, 2002年.

学術論文(審査論文):

1.富山 芳信 :
スガマデクスナトリウム(MK-8616, Org25969)の筋弛緩拮抗作用ー深い筋 弛緩状態からの回復ー,
麻酔, Vol.63, No.10, 1083-1088, 2014年.
(PubMed: 25693333,   CiNii: 40020224082)
2.Yoshinobu Tomiyama, Sachiyo Higashijima, Katsuyoshi Kume and Naohiro Oshita :
Trends in electrocardiographic R-wave amplitude during intraoperative pneumothorax,
The Journal of Medical Investigation : JMI, Vol.61, No.3,4, 442-445, 2014.
(徳島大学機関リポジトリ: 109603,   DOI: 10.2152/jmi.61.442,   PubMed: 25264070)
3.大下 修弘, 髙田 香, 河原 富也, 富山 芳信, 川人 伸次 :
術中冠攣縮が疑われた糖尿病患者の1症例,
臨床麻酔, Vol.38, No.4, 615-618, 2014年.
4.Kaori Takata, Yoshinobu Tomiyama, Katsuya Tanaka and Shuzo Oshita :
Cardioprotective effects of hyperkalemia during smulated ischemia/reperfusion in neonatal rat cardiomyocytes - Preservation of Na+/K+-ATPase activity -,
The Journal of Medical Investigation : JMI, Vol.60, No.1,2,, 66-76, 2013.
(DOI: 10.2152/jmi.60.66,   PubMed: 23614914)
5.Naohiro Ohshita, Katsuya Tanaka, Yoko Sakai, Toshiko Katayama, Yoshinobu Tomiyama, Shuzo Ohsita and Yasuo M. Tsutsumi :
Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease.,
The Journal of Medical Investigation : JMI, Vol.60, No.1-2, 146-148, 2013.
(徳島大学機関リポジトリ: 106049,   DOI: 10.2152/jmi.60.146,   PubMed: 23614923)
6.大下 修弘, 堤 保夫, 笠井 飛鳥, 曽我 朋宏, 金村 朋美, 片山 俊子, 井関 明生, 富山 芳信, 田中 克哉 :
スガマデクス投与後にアナフィラキシー様反応を呈した2症例,
麻酔, Vol.61, No.11, 1261-1264, 2012年.
(PubMed: 23236935,   CiNii: 40019480729,   Elsevier: Scopus)
7.大下 修弘, 堤 保夫, 大下 修造, 髙田 香, 富山 芳信, 田中 克哉 :
筋萎縮性側索硬化症患者の麻酔経験,
麻酔, Vol.61, No.9, 1006-1008, 2012年.
(PubMed: 23012840,   CiNii: 40019423075,   Elsevier: Scopus)
8.河野 裕明, 真鍋 佐和, 髙田 香, 曽我 朋宏, 富山 芳信, 大下 修造 :
胸部大動脈瘤により高度気管狭窄を呈した症例の麻酔経験,
麻酔, Vol.60, No.10, 1195-1198, 2011年.
(PubMed: 22111364,   CiNii: 40019005179,   Elsevier: Scopus)
9.富山 芳信, 野村 佳代, 角田 奈美 :
重症筋無力症患者にロクロニウムとスガマデクスを使用した2症例,
日本臨床麻酔学会誌, Vol.31, No.5, 791-797, 2011年.
(DOI: 10.2199/jjsca.31.791,   CiNii: 10029770089)
10. Yasuo M. Tsutsumi, Yoshinobu Tomiyama, Yousuke T. Horikawa, Yoko Sakai, Naohiro Ohshita, Katsuya Tanaka and Shuzo Oshita :
General anesthesia for electroconvulsive therapy with Brugada electrocardiograph pattern.,
The Journal of Medical Investigation : JMI, Vol.58, No.3-4, 273-276, 2011.
(徳島大学機関リポジトリ: 83841,   DOI: 10.2152/jmi.58.273,   PubMed: 21921431)
11.大下 修弘, 富山 芳信, 堤 保夫, 角田 奈美, 曽我 朋宏, 井関 明生, 大下 修造, 田中 克哉 :
ベッカー型筋ジストロフィ症患者の麻酔経験,
麻酔, Vol.60, No.8, 950-952, 2011年.
(PubMed: 21861423,   CiNii: 40018942899,   Elsevier: Scopus)
12.大下 修弘, 富山 芳信, 井関 明生, 河野 裕明, 角田 奈美, 堤 保夫, 大下 修造 :
Angelman症候群の麻酔経験,
麻酔, Vol.59, No.4, 484-486, 2010年.
(PubMed: 20420140,   CiNii: 40017090686,   Elsevier: Scopus)
13.Mikiyo Yamaguchi, Yoshinobu Tomiyama, Tosiko Katayama, Hiroshi Kitahata and Shuzo Oshita :
Involvement of adenosine triphosphate-sensitive potassium channels in the response of membrane potential to hyperosmolality in cultured human aorta endothelial cells.,
Anesthesia & Analgesia, Vol.100, No.2, 419-426, 2005.
(DOI: 10.1213/01.ANE.0000143350.82645.5B,   PubMed: 15673869)
14.Takashi Kawano, Shuzo Oshita, Akira Takahashi, Y Tsutsumi, Katsuya Tanaka, Yoshinobu Tomiyama, Hiroshi Kitahata and Yutaka Nakaya :
Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels.,
Anesthesiology, Vol.102, No.1, 93-101, 2005.
(DOI: 10.1097/00000542-200501000-00017,   PubMed: 15618792)
15.Takashi Kawano, Shuzo Oshita, Akira Takahashi, Yasuo Tsutsumi, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda and Yutaka Nakaya :
Molecular Mechanisms of the Inhibitory Effects of Bupivacaine, Levobupivacaine, and Ropivacaine on Sarcolemmal Adenosine Triphosphate-sensitive Potassium Channels in the Cardiovascular System.,
Anesthesiology, Vol.101, No.2, 390-398, 2004.
(DOI: 10.1097/00000542-200408000-00020,   PubMed: 15277922)
16.Takako Masuda, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda and Shuzo Oshita :
Effect of propofol on hypotonic swelling-induced membrane depolarization in human coronary artery smooth muscle cells.,
Anesthesiology, Vol.100, No.3, 648-656, 2004.
(DOI: 10.1097/00000542-200403000-00027,   PubMed: 15108981)
17.Takashi Kawano, Shuzo Oshita, Akira Takahashi, Yasuo Tsutsumi, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda and Yutaka Nakaya :
Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels.,
Anesthesiology, Vol.100, No.2, 338-346, 2004.
(DOI: 10.1097/00000542-200402000-00024,   PubMed: 14739809)
18.Katsuya Tanaka, Hiroshi Kitahata, Shinji Kawahito, Junpei Nozaki, Yoshinobu Tomiyama and Shuzo Oshita :
Phenylephrine increases pulmonary blood flow in children with tetralogy of Fallot.,
Canadian Journal of Anaesthesia, Vol.50, No.9, 926-929, 2003.
(DOI: 10.1007/BF03018741,   PubMed: 14617591,   Thomson Reuters: Web of Science™)
19.Takako Masuda, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda and Shuzo Oshita :
Propofol inhibits volume-sensitive chloride channels in human coronary artery smooth muscle cells.,
Anesthesia & Analgesia, Vol.97, No.3, 657-662, 2003.
(DOI: 10.1213/01.ANE.0000076060.48760.BD,   PubMed: 12933379)
20.Takashi Kawano, Shuzo Oshita, Yasuo Tsutsumi, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda, Akira Takahashi and Yutaka Nakaya :
Clinically relevant concentrations of propofol have no effect on adenosine triphosphate-sensitive potassium channels in rat ventricular myocytes.,
Anesthesiology, Vol.96, No.6, 1472-1477, 2002.
(DOI: 10.1097/00000542-200206000-00029,   PubMed: 12170062,   Thomson Reuters: Web of Science™,   Elsevier: Scopus)
21.Yasuo Tsutsumi, Shuzo Oshita, Takashi Kawano, Hiroshi Kitahata, Yoshinobu Tomiyama, Yasuhiro Kuroda and Yutaka Nakaya :
Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes.,
Anesthesiology, Vol.95, No.3, 766-770, 2001.
(DOI: 10.1097/00000542-200109000-00032,   PubMed: 11575552,   Thomson Reuters: Web of Science™,   Elsevier: Scopus)
22.Yoshinobu Tomiyama, Jr. E. B rian Johnney and Todd M Michael :
Plasma viscosity and cerebral blood flow,
American Journal of Physiology, Heart and Circulatory Physiology, Vol.279, No.4, H1949-H1954, 2000.
(PubMed: 11009484,   Thomson Reuters: Web of Science™,   Elsevier: Scopus)
23.Yoshinobu Tomiyama, Jr. E. B rian Johnney and Todd M Michael :
Cerebral blood flow during hemodilution and hypoxia in rats: Role of ATP-sensitive potassium channels,
Stroke, Vol.30, No.9, 1942-1948, 1999.
(PubMed: 10471448)
24.Yoshinobu Tomiyama, Kevin Jansen, Johnny Jr E Brian and Michael M Todd :
Hemodilution, cerebral O2 delivery and cerebral blood flow: a study using hyperbaric oxygenation,
American Journal of Physiology, Heart and Circulatory Physiology, Vol.276, No.4, H1190-H1196, 1999.
(PubMed: 10199842,   Elsevier: Scopus)

国際会議:

1.Yoshinobu Tomiyama, Kaori Takata, Katsuya Tanaka and Shuzo Oshita :
The effects of hyperkalemia and ouabain during Ischemia on the membrane potential during ischemia/reperfusion,
The Annual Meeting of the American Society of Anesthesiologists, Oct. 2011.
2.Yoshinobu Tomiyama :
Clinical usefulness of new drug. Sugammadex, for optimal reversal of neuromuscular block,
日中麻酔科学会議, 徳島, Nov. 2010.
3.Yoshinobu Tomiyama, Kaori Takata, Katsuya Tanaka and Shuzo Oshita :
The Effects of Hyperkalemia and Ouabain on Membrane Integrity during Ischemia/Reperfusion.,
American Society of Anesthesiologists 2010 Annual Meeting, Oct. 2010.
4.Kaori Takata, Yoshinobu Tomiyama, Katsuya Tanaka, Hiroshi Kitahata and Shuzo Oshita :
Role of hyperkalemia and Na+/K+ ATPase in myocardial protection during simulated ischemia.,
The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 2009.
5.Hiroshi Kitahata, Junpei Nozaki, Shinji Kawahito, Yoshinobu Tomiyama and Shuzo Oshita :
Interaction of the β1-blocker landiolol with early and late sevoflurane-induced preconditioning.,
The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 2009.
6.Nakamura Tomoka, Shinji Kawahito, Hiroshi Kitahata, Yoshinobu Tomiyama and Shuzo Oshita :
Intensive insulin therapy in patients undergoing living-related liver transplantation.,
The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 2008.
7.Shinji Kawahito, Akio Iseki, Yoshinobu Tomiyama, Hiroshi Kitahata and Shuzo Oshita :
High-frequency jet ventilation during thoracoscopic sympathectomy for palmar hyperhidrosis.,
The Annual Meeting of the American Society of Anesthesiologists, San Francisco, Oct. 2007.
8.Hiroshi Kitahata, Junpei Nozaki, Shinji Kawahito, Yoshinobu Tomiyama and Shuzo Oshita :
The involvement of the mitochondrial KATP channel on heat-shock protein-induced cardioprotection.,
The Annual Meeting of the American Society of Anesthesiologists, Chicago, Oct. 2006.
9.Yoshinobu Tomiyama, Yamaguchi Mikiyo, Satoru Eguchi, Hiroshi Kitahata and Shuzo Oshita :
Effects of propofol on the changes in membrane potential induced by simulated ischemia/reperfusion by means of mitochondrial uncoupler in cultured human coronary artery endothelial cells.,
The Annual Meeting of the American Society of Anesthesiologists, Atlanta, Oct. 2005.
10.Hiroshi Kitahata, Junpei Nozaki, Shinji Kawahito, Yoshinobu Tomiyama and Shuzo Oshita :
Influences of sevoflurane in myocardial protection of an ultra-short-acting β1-blocker, landiolol.,
The Annual Meeting of the American Society of Anesthesiologists, Atlanta, Oct. 2005.
11.Yoshinobu Tomiyama, Tosiko Katayama, Yamaguchi Mikiyo, Hiroshi Kitahata and Shuzo Oshita :
Involvement of Na+/K+ ATPase in the response of membrane potential to mannitol-induced hyperosmolality in cultured human coronary endothelial cells.,
The Annual Meeting of the American Society of Anesthesiologists, Las Vegas, Oct. 2004.
12.Takashi Kawano, Yasuo Tsutsumi, Shuzo Oshita, Yoshinobu Tomiyama and Hiroshi Kitahata :
Effects of propofol and fentanyl on ATP-sensitive potassium channels in cloned pancreatic β-cells.,
The Annual Meeting of the American Society of Anesthesiologists, Vol.A-51, Orlando, Oct. 2002.
13.Takashi Kawano, Yasuo Tsutsumi, Shuzo Oshita, Yoshinobu Tomiyama and Hiroshi Kitahata :
Effects of propofol on cloned ATP-sensitive potassium channels in ventricular myocytes are different from those in vascular smooth muscle cells.,
The Annual Meeting of the American Society of Anesthesiologists, Vol.A-50, Orlando, Oct. 2002.
14.Yoshinobu Tomiyama, Takako Masuda, Hiroshi Kitahata, Yasuhiro Kuroda and Shuzo Oshita :
Propofol inhibits volume-sensitive chloride channels in human coronary artery smooth muscle cells.,
The Annual Meeting of the American Society of Anesthesiologists, Vol.A-629, New Orleans, Oct. 2001.
15.Yoshinobu Tomiyama, Takako Masuda, Hiroshi Kitahata, Yasuhiro Kuroda and Shuzo Oshita :
Volume-sensitive chloride channels in human coronary artery smooth muscle cells.,
The Annual Meeting of the American Society of Anesthesiologists, Vol.A-630, Orlando, Oct. 2001.
16.Hideyuki Kimura, Yoshiaki Hirose, Katsuya Tanaka, Shinji Kawahito, Yoshinobu Tomiyama, Hiroshi Kitahata and Shuzo Oshita :
Nitric oxide dose not play a major role in regulation of systemic hemodynamic response to acute normovolemic hemodilution.,
The Annual Meeting of the American Society of Anesthesiologists, San Diego, Oct. 1997.
17.Yoshinobu Tomiyama, Satoshi Yasumoto, Hiroshi Kitahata, Hideyuki Kimura and Shuzo Oshita :
Coagulation status of the whole blood preoperatively obtained in the operating room and preserved at room temperature: Thrombelastographic evaluation.,
The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 1996.

国内講演発表:

1.高石 和美, 川人 伸次, 原田 永勝, 富山 芳信, 北畑 洋 :
新生児ラット心筋細胞におけるβ3受容体刺激が一酸化窒素産生に及ぼす影響,
日本麻酔科学会 第60回学術集会, 2013年5月.
2.角田 奈美, 門田 尚子, 田中 克哉, 堤 保夫, 曽我 朋宏, 髙田 香, 富山 芳信, 大下 修造 :
食道癌により食道気管廔を形成した患者に右用ダブルルーメンチューブを用いて麻酔管理をした一症例,
日本臨床麻酔学会第31回大会, 2011年11月.
3.富山 芳信 :
手術室運用の改善と解決すべき課題,
日本麻酔科学会中国・四国支部学術集会, 2011年9月.
4.富山 芳信, 野村 佳世, 角田 奈美, 大下 修造 :
重症筋無力症に,ロクロニウムとスガマデクスを使用した症例,
日本臨床麻酔学会第30回大会, 2010年11月.
5.江口 覚, 山下 菊治, 石川 友康, 富山 芳信, 大下 修弘, 細川 浩良, 北村 清一郎, 中條 信義 :
遠赤外線照射は麻酔効果を抑制する,
第22回麻酔メカニズム研究会, 2004年7月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

  • 心筋虚血時に細胞外に蓄積するKイオンは、細胞内Caイオンの上昇を抑制するか (研究課題/領域番号: 19591801 )
  • 生体吸収性ポリマーを用いた人工血管の開発 (研究課題/領域番号: 16592004 )
  • 脳血流の自己調節機構(AR)を非侵襲的に評価できる数理モデルの開発 (研究課題/領域番号: 15659428 )
  • 心保護効果における細胞膜とミトコンドリアのATP感受性Kチャネルの相互作用 (研究課題/領域番号: 15591636 )
  • 容量感受性クロライドチャネル活性化に及ぼす麻酔薬の影響 (研究課題/領域番号: 12671476 )
  • 希釈式自己血輸血における代用血漿投与が血液凝固線溶系および腎機能に及ぼす影響 (研究課題/領域番号: 08771196 )
  • 虚血時および再灌流時の心筋細胞内カルシウム濃度変化に及ぼす灌流温低下の効果 (研究課題/領域番号: 07671665 )
  • 研究者番号(30243702)による検索